locus-tag	class	description
UPTC3659_RS00010	COG0592	DNA-directed DNA polymerase activity
UPTC3659_RS00015	COG0187	DNA topoisomerase II activity
UPTC3659_RS00040	COG0830	nickel cation binding
UPTC3659_RS00045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
UPTC3659_RS00050	COG0829	nickel cation binding
UPTC3659_RS00055	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UPTC3659_RS00075	COG2824	Alkylphosphonate utilization operon protein PhnA
UPTC3659_RS00085	COG0504	CTP synthase activity
UPTC3659_RS00090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
UPTC3659_RS00100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
UPTC3659_RS00105	COG0268	Binds directly to 16S ribosomal RNA
UPTC3659_RS00110	COG1187	pseudouridine synthase activity
UPTC3659_RS00115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UPTC3659_RS00130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UPTC3659_RS00135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UPTC3659_RS00140	COG0564	pseudouridine synthase activity
UPTC3659_RS00145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
UPTC3659_RS00150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UPTC3659_RS00155	COG1297	OPT oligopeptide transporter protein
UPTC3659_RS00160	COG1968	undecaprenyl-diphosphatase activity
UPTC3659_RS00165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UPTC3659_RS00170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UPTC3659_RS00180	COG2378	regulation of single-species biofilm formation
UPTC3659_RS00220	COG1160	GTP binding
UPTC3659_RS00245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
UPTC3659_RS00250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UPTC3659_RS00255	COG1793	dna ligase
UPTC3659_RS00260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UPTC3659_RS00265	COG1121	(ABC) transporter
UPTC3659_RS00275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UPTC3659_RS00290	COG0418	dihydroorotase activity
UPTC3659_RS00305	COG2194	sulfuric ester hydrolase activity
UPTC3659_RS00310	COG0708	Exodeoxyribonuclease III
UPTC3659_RS00315	COG1971	Probably functions as a manganese efflux pump
UPTC3659_RS00330	COG1328	CTP reductase activity
UPTC3659_RS00335	COG0602	queuosine metabolic process
UPTC3659_RS00340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UPTC3659_RS00350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UPTC3659_RS00360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
UPTC3659_RS00365	COG2992	FlgJ-related protein
UPTC3659_RS00380	COG0051	transcription antitermination factor activity, RNA binding
UPTC3659_RS00385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UPTC3659_RS00390	COG0088	Forms part of the polypeptide exit tunnel
UPTC3659_RS00395	COG0089	rRNA binding
UPTC3659_RS00400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UPTC3659_RS00405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UPTC3659_RS00410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UPTC3659_RS00415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UPTC3659_RS00420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UPTC3659_RS00425	COG0255	Belongs to the universal ribosomal protein uL29 family
UPTC3659_RS00430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UPTC3659_RS00435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UPTC3659_RS00440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UPTC3659_RS00445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
UPTC3659_RS00450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UPTC3659_RS00455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UPTC3659_RS00460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UPTC3659_RS00465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
UPTC3659_RS00470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UPTC3659_RS00475	COG0200	Binds to the 23S rRNA
UPTC3659_RS00480	COG0201	protein transport
UPTC3659_RS00485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
UPTC3659_RS00490	COG0252	asparaginase activity
UPTC3659_RS00495	COG1592	Rubrerythrin
UPTC3659_RS00510	COG1902	pentaerythritol trinitrate reductase activity
UPTC3659_RS00515	COG0814	amino acid
UPTC3659_RS00520	COG1760	l-serine dehydratase
UPTC3659_RS00525	COG0024	Methionine aminopeptidase
UPTC3659_RS00530	COG0840	transmembrane signaling receptor activity
UPTC3659_RS00535	COG1858	cytochrome C peroxidase
UPTC3659_RS00540	COG0477	Major facilitator Superfamily
UPTC3659_RS00545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UPTC3659_RS00550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UPTC3659_RS00555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UPTC3659_RS00560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UPTC3659_RS00565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UPTC3659_RS00575	COG0203	ribosomal protein L17
UPTC3659_RS00580	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
UPTC3659_RS00590	COG0131	Imidazoleglycerol-phosphate dehydratase
UPTC3659_RS00590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
UPTC3659_RS00605	COG0107	imidazoleglycerol-phosphate synthase activity
UPTC3659_RS00610	COG0140	phosphoribosyl-ATP diphosphatase activity
UPTC3659_RS00610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UPTC3659_RS00615	COG1749	Flagellar hook protein flgE
UPTC3659_RS00620	COG2814	Major facilitator Superfamily
UPTC3659_RS00625	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
UPTC3659_RS00635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UPTC3659_RS00640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
UPTC3659_RS00655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
UPTC3659_RS00660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
UPTC3659_RS00670	COG3008	intermembrane lipid transfer
UPTC3659_RS00690	COG1917	Cupin 2, conserved barrel domain protein
UPTC3659_RS00690	COG2207	Transcriptional regulator
UPTC3659_RS00705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UPTC3659_RS00710	COG0642	Histidine kinase
UPTC3659_RS00715	COG0745	RESPONSE REGULATOR receiver
UPTC3659_RS00730	COG1194	a g-specific adenine glycosylase
UPTC3659_RS00770	COG0569	domain protein
UPTC3659_RS00775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UPTC3659_RS00780	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
UPTC3659_RS00785	COG1027	Aspartate ammonia-lyase
UPTC3659_RS00790	COG0840	transmembrane signaling receptor activity
UPTC3659_RS00795	COG0840	transmembrane signaling receptor activity
UPTC3659_RS00805	COG2921	Belongs to the UPF0250 family
UPTC3659_RS00810	COG0315	cyclic pyranopterin monophosphate synthase activity
UPTC3659_RS00830	COG2346	COG2346, Truncated hemoglobins
UPTC3659_RS00845	COG0148	phosphopyruvate hydratase activity
UPTC3659_RS00850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UPTC3659_RS00860	COG1987	bacterial-type flagellum assembly
UPTC3659_RS00875	COG1218	3'(2'),5'-bisphosphate nucleotidase
UPTC3659_RS00880	COG0569	domain protein
UPTC3659_RS00880	COG0475	glutathione-regulated potassium exporter activity
UPTC3659_RS00885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UPTC3659_RS00890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UPTC3659_RS00895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UPTC3659_RS00940	COG2089	acid synthase
UPTC3659_RS00950	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UPTC3659_RS00950	COG1776	CheC inhibitor of MCP methylation
UPTC3659_RS00960	COG0248	Ppx GppA phosphatase
UPTC3659_RS00965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
UPTC3659_RS00970	COG0745	RESPONSE REGULATOR receiver
UPTC3659_RS00980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
UPTC3659_RS00990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UPTC3659_RS01000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UPTC3659_RS01010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
UPTC3659_RS01015	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
UPTC3659_RS01015	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
UPTC3659_RS01020	COG1192	Involved in chromosome partitioning
UPTC3659_RS01025	COG1475	DNA binding
UPTC3659_RS01040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UPTC3659_RS01045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
UPTC3659_RS01050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UPTC3659_RS01055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UPTC3659_RS01060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
UPTC3659_RS01065	COG0811	peptide transport
UPTC3659_RS01070	COG0848	biopolymer transport protein
UPTC3659_RS01100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UPTC3659_RS01105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UPTC3659_RS01110	COG0037	tRNA processing
UPTC3659_RS01130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UPTC3659_RS01145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
UPTC3659_RS01150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UPTC3659_RS01155	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UPTC3659_RS01160	COG0287	Prephenate dehydrogenase
UPTC3659_RS01170	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
UPTC3659_RS01180	COG0083	homoserine kinase activity
UPTC3659_RS01190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
UPTC3659_RS01200	COG0779	Required for maturation of 30S ribosomal subunits
UPTC3659_RS01205	COG1401	restriction endodeoxyribonuclease activity
UPTC3659_RS01215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UPTC3659_RS01215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UPTC3659_RS01225	COG0402	S-adenosylhomocysteine deaminase activity
UPTC3659_RS01230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
UPTC3659_RS01235	COG0006	proline dipeptidase activity
UPTC3659_RS01240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UPTC3659_RS01245	COG1419	protein localization to endoplasmic reticulum
UPTC3659_RS01250	COG0455	bacterial-type flagellum organization
UPTC3659_RS01260	COG1191	sigma factor activity
UPTC3659_RS01265	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UPTC3659_RS01270	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UPTC3659_RS01270	COG1776	CheC inhibitor of MCP methylation
UPTC3659_RS01275	COG1611	Belongs to the LOG family
UPTC3659_RS01280	COG0482	sulfurtransferase activity
UPTC3659_RS01285	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
UPTC3659_RS01295	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
UPTC3659_RS01300	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UPTC3659_RS01305	COG2046	Belongs to the sulfate adenylyltransferase family
UPTC3659_RS01310	COG0745	RESPONSE REGULATOR receiver
UPTC3659_RS01315	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
UPTC3659_RS01315	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
UPTC3659_RS01320	COG0489	protein tyrosine kinase activity
UPTC3659_RS01325	COG2171	N-acyltransferase activity
UPTC3659_RS01335	COG0783	Belongs to the Dps family
UPTC3659_RS01340	COG0166	Belongs to the GPI family
UPTC3659_RS01350	COG1739	Uncharacterized protein family UPF0029
UPTC3659_RS01365	COG0488	(ABC) transporter
UPTC3659_RS01375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UPTC3659_RS01395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UPTC3659_RS01415	COG2855	membrane
UPTC3659_RS01420	COG0583	DNA-binding transcription factor activity
UPTC3659_RS01430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UPTC3659_RS01445	COG0736	holo-[acyl-carrier-protein] synthase activity
UPTC3659_RS01450	COG1580	Controls the rotational direction of flagella during chemotaxis
UPTC3659_RS01460	COG0753	catalase activity
UPTC3659_RS01470	COG0165	Argininosuccinate lyase
UPTC3659_RS01485	COG0251	oxidation-reduction process
UPTC3659_RS01490	COG3069	C4-dicarboxylate transmembrane transporter activity
UPTC3659_RS01505	COG2079	MmgE PrpD family protein
UPTC3659_RS01510	COG1918	ferrous iron import across plasma membrane
UPTC3659_RS01515	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
UPTC3659_RS01520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UPTC3659_RS01525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UPTC3659_RS01530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UPTC3659_RS01535	COG0825	malonyl-CoA metabolic process
UPTC3659_RS01545	COG2833	Protein of unknown function (DUF455)
UPTC3659_RS01570	COG0517	IMP dehydrogenase activity
UPTC3659_RS01570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
UPTC3659_RS01575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UPTC3659_RS01580	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
UPTC3659_RS01610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UPTC3659_RS01630	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
UPTC3659_RS01640	COG0175	sulfate reduction
UPTC3659_RS01645	COG2895	sulfate adenylyltransferase (ATP) activity
UPTC3659_RS01650	COG3273	potassium ion transport
UPTC3659_RS01650	COG0471	metal ion transport
UPTC3659_RS01655	COG0529	Catalyzes the synthesis of activated sulfate
UPTC3659_RS01705	COG0195	Participates in both transcription termination and antitermination
UPTC3659_RS01720	COG2121	Domain of unknown function (DUF374)
UPTC3659_RS01745	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
UPTC3659_RS01755	COG1053	succinate dehydrogenase
UPTC3659_RS01760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UPTC3659_RS01775	COG2249	NAD(P)H dehydrogenase (quinone) activity
UPTC3659_RS01790	COG1733	regulation of RNA biosynthetic process
UPTC3659_RS01800	COG1064	alcohol dehydrogenase
UPTC3659_RS01810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
UPTC3659_RS01835	COG0303	'Molybdopterin
UPTC3659_RS01840	COG0314	molybdopterin synthase activity
UPTC3659_RS01875	COG0243	molybdopterin cofactor binding
UPTC3659_RS01880	COG3383	formate dehydrogenase (NAD+) activity
UPTC3659_RS01885	COG0437	4 iron, 4 sulfur cluster binding
UPTC3659_RS01895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UPTC3659_RS01895	COG0425	Belongs to the sulfur carrier protein TusA family
UPTC3659_RS01900	COG0709	Synthesizes selenophosphate from selenide and ATP
UPTC3659_RS01910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UPTC3659_RS01915	COG0425	Belongs to the sulfur carrier protein TusA family
UPTC3659_RS01930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
UPTC3659_RS01950	COG0505	Belongs to the CarA family
UPTC3659_RS02015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UPTC3659_RS02020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UPTC3659_RS02025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
UPTC3659_RS02025	COG2885	chlorophyll binding
UPTC3659_RS02030	COG0546	phosphoglycolate phosphatase activity
UPTC3659_RS02055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UPTC3659_RS02060	COG1459	type II secretion system
UPTC3659_RS02090	COG3951	Flagellar rod assembly protein muramidase FlgJ
UPTC3659_RS02095	COG1706	bacterial-type flagellum-dependent cell motility
UPTC3659_RS02120	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
UPTC3659_RS02135	COG0716	FMN binding
UPTC3659_RS02140	COG0840	transmembrane signaling receptor activity
UPTC3659_RS02165	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
UPTC3659_RS02175	COG0126	phosphoglycerate kinase activity
UPTC3659_RS02180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UPTC3659_RS02235	COG0114	fumarate hydratase activity
UPTC3659_RS02240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UPTC3659_RS02250	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
UPTC3659_RS02255	COG2252	PERMEase
UPTC3659_RS02265	COG0243	molybdopterin cofactor binding
UPTC3659_RS02285	COG4773	Receptor
UPTC3659_RS02290	COG3022	response to hydroperoxide
UPTC3659_RS02315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UPTC3659_RS02320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UPTC3659_RS02335	COG0250	Participates in transcription elongation, termination and antitermination
UPTC3659_RS02340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
UPTC3659_RS02345	COG0081	regulation of translation
UPTC3659_RS02350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
UPTC3659_RS02355	COG0222	ribosome binding
UPTC3659_RS02360	COG0085	RNA polymerase activity
UPTC3659_RS02365	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UPTC3659_RS02370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UPTC3659_RS02375	COG0049	tRNA binding
UPTC3659_RS02380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UPTC3659_RS02385	COG1253	flavin adenine dinucleotide binding
UPTC3659_RS02390	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
UPTC3659_RS02395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UPTC3659_RS02465	COG0252	asparaginase activity
UPTC3659_RS02490	COG0848	biopolymer transport protein
UPTC3659_RS02495	COG0811	peptide transport
UPTC3659_RS02510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UPTC3659_RS02515	COG2217	Heavy metal translocating P-type atpase
UPTC3659_RS02530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
UPTC3659_RS02535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UPTC3659_RS02540	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
UPTC3659_RS02540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UPTC3659_RS02545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
UPTC3659_RS02555	COG0579	oxidoreductase
UPTC3659_RS02580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UPTC3659_RS02600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UPTC3659_RS02615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UPTC3659_RS02620	COG0484	heat shock protein binding
UPTC3659_RS02625	COG0745	RESPONSE REGULATOR receiver
UPTC3659_RS02630	COG0642	Histidine kinase
UPTC3659_RS02635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UPTC3659_RS02660	COG0519	Catalyzes the synthesis of GMP from XMP
UPTC3659_RS02660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UPTC3659_RS02665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UPTC3659_RS02685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
UPTC3659_RS02695	COG1185	polyribonucleotide nucleotidyltransferase activity
UPTC3659_RS02785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UPTC3659_RS02795	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
UPTC3659_RS02800	COG0653	protein targeting
UPTC3659_RS02805	COG2204	response regulator
UPTC3659_RS02810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UPTC3659_RS02820	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
UPTC3659_RS02825	COG0731	radical SAM domain protein
UPTC3659_RS02840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UPTC3659_RS02850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UPTC3659_RS02855	COG1160	GTP binding
UPTC3659_RS02865	COG2233	PERMEase
UPTC3659_RS02875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
UPTC3659_RS02880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UPTC3659_RS02885	COG0284	orotidine-5'-phosphate decarboxylase activity
UPTC3659_RS02900	COG0138	bifunctional purine biosynthesis protein purh
UPTC3659_RS02905	COG0484	heat shock protein binding
UPTC3659_RS02910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UPTC3659_RS02925	COG0706	membrane insertase activity
UPTC3659_RS02940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
UPTC3659_RS02960	COG0824	Thioesterase
UPTC3659_RS02975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UPTC3659_RS02995	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
UPTC3659_RS03000	COG2195	Cleaves the N-terminal amino acid of tripeptides
UPTC3659_RS03020	COG0500	methyltransferase
UPTC3659_RS03035	COG2890	protein-(glutamine-N5) methyltransferase activity
UPTC3659_RS03050	COG0488	(ABC) transporter
UPTC3659_RS03055	COG1408	metallophosphoesterase
UPTC3659_RS03060	COG0688	phosphatidylethanolamine metabolic process
UPTC3659_RS03065	COG2257	FlhB HrpN YscU SpaS Family
UPTC3659_RS03090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UPTC3659_RS03105	COG0681	Belongs to the peptidase S26 family
UPTC3659_RS03115	COG0343	queuine tRNA-ribosyltransferase activity
UPTC3659_RS03130	COG0439	Biotin carboxylase
UPTC3659_RS03150	COG0772	Belongs to the SEDS family
UPTC3659_RS03155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UPTC3659_RS03160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UPTC3659_RS03180	COG0642	Histidine kinase
UPTC3659_RS03190	COG0582	viral genome integration into host DNA
UPTC3659_RS03205	COG3561	AntA/AntB antirepressor
UPTC3659_RS03225	COG0863	Belongs to the N(4) N(6)-methyltransferase family
UPTC3659_RS03460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
UPTC3659_RS03465	COG1126	abc transporter atp-binding protein
UPTC3659_RS03470	COG0765	amino acid transport
UPTC3659_RS03475	COG1115	amino acid carrier protein
UPTC3659_RS03480	COG0751	glycine-tRNA ligase activity
UPTC3659_RS03485	COG0739	heme binding
UPTC3659_RS03495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UPTC3659_RS03495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UPTC3659_RS03515	COG0772	Belongs to the SEDS family
UPTC3659_RS03520	COG0564	pseudouridine synthase activity
UPTC3659_RS03530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UPTC3659_RS03535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UPTC3659_RS03550	COG0528	UMP kinase activity
UPTC3659_RS03555	COG1758	RNA polymerase activity
UPTC3659_RS03560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UPTC3659_RS03565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
UPTC3659_RS03580	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
UPTC3659_RS03580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UPTC3659_RS03585	COG0840	transmembrane signaling receptor activity
UPTC3659_RS03600	COG0750	zinc metalloprotease
UPTC3659_RS03605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
UPTC3659_RS03610	COG1028	Short-chain dehydrogenase reductase Sdr
UPTC3659_RS03615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UPTC3659_RS03620	COG0612	Peptidase, M16
UPTC3659_RS03625	COG0167	dihydroorotate dehydrogenase activity
UPTC3659_RS03630	COG1132	(ABC) transporter
UPTC3659_RS03635	COG0215	cysteine-tRNA ligase activity
UPTC3659_RS03640	COG0728	peptidoglycan biosynthetic process
UPTC3659_RS03650	COG0632	four-way junction helicase activity
UPTC3659_RS03655	COG1181	Belongs to the D-alanine--D-alanine ligase family
UPTC3659_RS03670	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UPTC3659_RS03675	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
UPTC3659_RS03680	COG0280	phosphate acetyltransferase
UPTC3659_RS03685	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UPTC3659_RS03690	COG1464	Belongs to the NlpA lipoprotein family
UPTC3659_RS03700	COG2011	ABC-type metal ion transport system permease component
UPTC3659_RS03705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UPTC3659_RS03720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
UPTC3659_RS03725	COG0563	adenylate kinase activity
UPTC3659_RS03735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UPTC3659_RS03740	COG0497	DNA recombination
UPTC3659_RS03750	COG0084	hydrolase, TatD family'
UPTC3659_RS03755	COG0741	lytic transglycosylase activity
UPTC3659_RS03755	COG1388	LysM domain
UPTC3659_RS03760	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
UPTC3659_RS03780	COG0218	Necessary for normal cell division and for the maintenance of normal septation
UPTC3659_RS03800	COG0805	protein transport
UPTC3659_RS03815	COG0640	Transcriptional regulator
UPTC3659_RS03825	COG0798	PFAM Bile acid sodium symporter
UPTC3659_RS03830	COG0748	coenzyme F420 binding
UPTC3659_RS03835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UPTC3659_RS03845	COG0527	aspartate kinase activity
UPTC3659_RS03860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UPTC3659_RS03865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UPTC3659_RS03870	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
UPTC3659_RS03875	COG0196	riboflavin kinase activity
UPTC3659_RS03880	COG2890	protein-(glutamine-N5) methyltransferase activity
UPTC3659_RS03910	COG0012	GTP binding
UPTC3659_RS03915	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UPTC3659_RS03935	COG0698	ribose 5-phosphate isomerase
UPTC3659_RS03940	COG2201	protein-glutamate methylesterase activity
UPTC3659_RS03945	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UPTC3659_RS03955	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
UPTC3659_RS03960	COG0612	Peptidase, M16
UPTC3659_RS03965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UPTC3659_RS03970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UPTC3659_RS03975	COG0765	amino acid transport
UPTC3659_RS03980	COG0765	amino acid transport
UPTC3659_RS03995	COG0477	Major facilitator Superfamily
UPTC3659_RS04020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UPTC3659_RS04030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UPTC3659_RS04035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UPTC3659_RS04040	COG0521	Mo-molybdopterin cofactor biosynthetic process
UPTC3659_RS04060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UPTC3659_RS04065	COG0204	Acyl-transferase
UPTC3659_RS04075	COG0047	phosphoribosylformylglycinamidine synthase activity
UPTC3659_RS04080	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UPTC3659_RS04085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
UPTC3659_RS04090	COG0793	Belongs to the peptidase S41A family
UPTC3659_RS04095	COG0542	response to heat
UPTC3659_RS04100	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
UPTC3659_RS04105	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
UPTC3659_RS04110	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
UPTC3659_RS04115	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
UPTC3659_RS04145	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
UPTC3659_RS04155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UPTC3659_RS04155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UPTC3659_RS04175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
UPTC3659_RS04180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
UPTC3659_RS04210	COG1794	racemase activity, acting on amino acids and derivatives
UPTC3659_RS04215	COG0582	viral genome integration into host DNA
UPTC3659_RS04240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UPTC3659_RS04245	COG0303	'Molybdopterin
UPTC3659_RS04270	COG4771	TonB-dependent receptor
UPTC3659_RS04275	COG4607	ABC-type enterochelin transport system periplasmic component
UPTC3659_RS04280	COG4604	ABC transporter, ATP-binding protein
UPTC3659_RS04285	COG4605	iron ion homeostasis
UPTC3659_RS04290	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UPTC3659_RS04300	COG0163	prenyltransferase activity
UPTC3659_RS04305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UPTC3659_RS04310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UPTC3659_RS04315	COG0124	histidyl-tRNA synthetase
UPTC3659_RS04320	COG1166	arginine decarboxylase activity
UPTC3659_RS04325	COG1045	serine acetyltransferase
UPTC3659_RS04335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UPTC3659_RS04340	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
UPTC3659_RS04345	COG1137	ATPase activity
UPTC3659_RS04350	COG0802	atpase or kinase
UPTC3659_RS04355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
UPTC3659_RS04360	COG0137	argininosuccinate synthase activity
UPTC3659_RS04365	COG0359	binds to the 23S rRNA
UPTC3659_RS04370	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
UPTC3659_RS04380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UPTC3659_RS04415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
UPTC3659_RS04420	COG0181	hydroxymethylbilane synthase activity
UPTC3659_RS04430	COG0442	prolyl-tRNA aminoacylation
UPTC3659_RS04435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
UPTC3659_RS04440	COG0142	geranyltranstransferase activity
UPTC3659_RS04470	COG0789	Transcriptional regulator
UPTC3659_RS04475	COG0484	heat shock protein binding
UPTC3659_RS04480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UPTC3659_RS04485	COG0745	RESPONSE REGULATOR receiver
UPTC3659_RS04490	COG0642	Histidine kinase
UPTC3659_RS04495	COG0210	DNA helicase
UPTC3659_RS04500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
UPTC3659_RS04515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UPTC3659_RS04520	COG0375	protein maturation
UPTC3659_RS04525	COG0309	Hydrogenase expression formation protein (HypE)
UPTC3659_RS04530	COG0409	Hydrogenase expression formation protein
UPTC3659_RS04535	COG0298	carbon dioxide binding
UPTC3659_RS04545	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
UPTC3659_RS04550	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
UPTC3659_RS04555	COG3340	Belongs to the peptidase S51 family
UPTC3659_RS04565	COG0534	Mate efflux family protein
UPTC3659_RS04580	COG0581	inorganic phosphate transmembrane transporter activity
UPTC3659_RS04590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UPTC3659_RS04600	COG2205	protein histidine kinase activity
UPTC3659_RS04605	COG1528	Iron-storage protein
UPTC3659_RS04615	COG0484	heat shock protein binding
UPTC3659_RS04630	COG1333	cytochrome c biogenesis protein
UPTC3659_RS04630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UPTC3659_RS04640	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UPTC3659_RS04645	COG0440	acetolactate synthase activity
UPTC3659_RS04650	COG0028	Belongs to the TPP enzyme family
UPTC3659_RS04660	COG1013	pyruvate-flavodoxin oxidoreductase activity
UPTC3659_RS04665	COG0674	pyruvate-flavodoxin oxidoreductase activity
UPTC3659_RS04665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
UPTC3659_RS04675	COG0039	L-malate dehydrogenase activity
UPTC3659_RS04690	COG1674	ftsk spoiiie
UPTC3659_RS04690	COG1196	nuclear chromosome segregation
UPTC3659_RS04695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UPTC3659_RS05095	COG3501	Rhs element vgr protein
UPTC3659_RS05155	COG3501	Rhs element vgr protein
UPTC3659_RS05220	COG3501	Rhs element vgr protein
UPTC3659_RS05285	COG3501	Rhs element vgr protein
UPTC3659_RS05530	COG0587	DNA-directed DNA polymerase activity
UPTC3659_RS05535	COG0693	protein deglycase activity
UPTC3659_RS05545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UPTC3659_RS05565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
UPTC3659_RS05575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
UPTC3659_RS05580	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
UPTC3659_RS05585	COG0456	acetyltransferase
UPTC3659_RS05590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UPTC3659_RS05595	COG0765	amino acid transport
UPTC3659_RS05610	COG2258	MOSC domain
UPTC3659_RS05615	COG1252	NADH dehydrogenase
UPTC3659_RS05620	COG0733	neurotransmitter:sodium symporter activity
UPTC3659_RS05640	COG0191	fructose-bisphosphate aldolase activity
UPTC3659_RS05645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UPTC3659_RS05650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UPTC3659_RS05655	COG0786	glutamate:sodium symporter activity
UPTC3659_RS05665	COG0577	efflux transmembrane transporter activity
UPTC3659_RS05665	COG1136	(ABC) transporter
UPTC3659_RS05670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UPTC3659_RS05675	COG0778	Nitroreductase
UPTC3659_RS05680	COG0318	PFAM AMP-dependent synthetase and ligase
UPTC3659_RS05680	COG0204	Acyl-transferase
UPTC3659_RS05685	COG2936	dipeptidyl-peptidase activity
UPTC3659_RS05695	COG0492	ferredoxin-NADP+ reductase activity
UPTC3659_RS05700	COG2813	Specifically methylates the guanine in position
UPTC3659_RS05715	COG0134	indole-3-glycerol-phosphate synthase activity
UPTC3659_RS05725	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
UPTC3659_RS05740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
UPTC3659_RS05765	COG0443	Heat shock 70 kDa protein
UPTC3659_RS05775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UPTC3659_RS05780	COG1420	regulation of RNA biosynthetic process
UPTC3659_RS05795	COG2404	hydrolase activity, acting on ester bonds
UPTC3659_RS05800	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UPTC3659_RS05805	COG1959	2 iron, 2 sulfur cluster binding
UPTC3659_RS05810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
UPTC3659_RS05820	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
UPTC3659_RS05835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UPTC3659_RS05840	COG0557	exoribonuclease II activity
UPTC3659_RS05850	COG0360	Binds together with S18 to 16S ribosomal RNA
UPTC3659_RS05855	COG0629	single-stranded DNA binding
UPTC3659_RS05860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UPTC3659_RS05865	COG2095	MarC family integral membrane protein
UPTC3659_RS05885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UPTC3659_RS05890	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
UPTC3659_RS05900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UPTC3659_RS05905	COG3290	protein histidine kinase activity
UPTC3659_RS05905	COG0840	transmembrane signaling receptor activity
UPTC3659_RS05910	COG0840	transmembrane signaling receptor activity
UPTC3659_RS05915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UPTC3659_RS05925	COG2814	Major facilitator Superfamily
UPTC3659_RS05935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UPTC3659_RS05940	COG1757	Na H antiporter
UPTC3659_RS05945	COG4221	oxidoreductase activity
UPTC3659_RS05950	COG0666	response to abiotic stimulus
UPTC3659_RS05975	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
UPTC3659_RS05995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
UPTC3659_RS06010	COG1338	Plays a role in the flagellum-specific transport system
UPTC3659_RS06020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
UPTC3659_RS06040	COG1393	Belongs to the ArsC family
UPTC3659_RS06045	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
UPTC3659_RS06055	COG0335	large ribosomal subunit rRNA binding
UPTC3659_RS06060	COG0336	Belongs to the RNA methyltransferase TrmD family
UPTC3659_RS06070	COG1837	Belongs to the UPF0109 family
UPTC3659_RS06075	COG0228	four-way junction DNA binding
UPTC3659_RS06080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UPTC3659_RS06085	COG0564	pseudouridine synthase activity
UPTC3659_RS06090	COG1519	Transferase
UPTC3659_RS06100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
UPTC3659_RS06105	COG0752	glycyl-tRNA synthetase alpha subunit
UPTC3659_RS06115	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UPTC3659_RS06120	COG0826	peptidase U32
UPTC3659_RS06130	COG0174	glutamine synthetase
UPTC3659_RS06135	COG0788	formyltetrahydrofolate deformylase activity
UPTC3659_RS06140	COG0617	tRNA 3'-terminal CCA addition
UPTC3659_RS06155	COG2807	transmembrane transport
UPTC3659_RS06170	COG3043	anaerobic respiration
UPTC3659_RS06175	COG0348	domain, Protein
UPTC3659_RS06180	COG0437	4 iron, 4 sulfur cluster binding
UPTC3659_RS06185	COG0243	molybdopterin cofactor binding
UPTC3659_RS06195	COG4786	Flagellar basal body rod
UPTC3659_RS06200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UPTC3659_RS06205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
UPTC3659_RS06215	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
UPTC3659_RS06230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UPTC3659_RS06235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UPTC3659_RS06250	COG0840	transmembrane signaling receptor activity
UPTC3659_RS06260	COG0459	protein refolding
UPTC3659_RS06265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UPTC3659_RS06285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
UPTC3659_RS06295	COG0739	heme binding
UPTC3659_RS06300	COG0285	dihydrofolate synthase activity
UPTC3659_RS06315	COG0495	leucyl-tRNA aminoacylation
UPTC3659_RS06325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UPTC3659_RS06330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UPTC3659_RS06335	COG1862	Preprotein translocase
UPTC3659_RS06340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
UPTC3659_RS06345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
UPTC3659_RS06350	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
UPTC3659_RS06355	COG0540	Belongs to the ATCase OTCase family
UPTC3659_RS06370	COG0210	DNA helicase
UPTC3659_RS06390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UPTC3659_RS06405	COG0542	response to heat
UPTC3659_RS06410	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
UPTC3659_RS06415	COG1815	bacterial-type flagellum-dependent cell motility
UPTC3659_RS06420	COG1558	bacterial-type flagellum-dependent cell motility
UPTC3659_RS06425	COG1677	Flagellar hook-basal body complex protein FliE
UPTC3659_RS06430	COG0768	penicillin binding
UPTC3659_RS06435	COG2226	methyltransferase
UPTC3659_RS06440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
UPTC3659_RS06445	COG0673	inositol 2-dehydrogenase activity
UPTC3659_RS06460	COG0424	maF-like protein
UPTC3659_RS06470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
UPTC3659_RS06480	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
UPTC3659_RS06490	COG2217	Heavy metal translocating P-type atpase
UPTC3659_RS06505	COG0217	transcriptional regulatory protein
UPTC3659_RS06510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UPTC3659_RS06520	COG0586	Pfam SNARE associated Golgi protein
UPTC3659_RS06535	COG3610	response to peptide
UPTC3659_RS06540	COG0018	arginyl-trna synthetase
UPTC3659_RS06545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UPTC3659_RS06550	COG0194	GDP metabolic process
UPTC3659_RS06560	COG1684	flagellar biosynthetic protein fliR
UPTC3659_RS06565	COG1136	(ABC) transporter
UPTC3659_RS06570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
UPTC3659_RS06575	COG0052	Belongs to the universal ribosomal protein uS2 family
UPTC3659_RS06590	COG0723	plastoquinol--plastocyanin reductase activity
UPTC3659_RS06610	COG1496	oxidoreductase activity
UPTC3659_RS06620	COG0642	Histidine kinase
UPTC3659_RS06630	COG2703	oxygen carrier activity
UPTC3659_RS06645	COG4773	Receptor
UPTC3659_RS06660	COG0683	leucine binding
UPTC3659_RS06685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UPTC3659_RS06685	COG1333	cytochrome c biogenesis protein
UPTC3659_RS06695	COG0481	GTPase activity
UPTC3659_RS06715	COG0352	thiamine-phosphate diphosphorylase activity
UPTC3659_RS06720	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
UPTC3659_RS06725	COG0351	phosphomethylpyrimidine kinase
UPTC3659_RS06730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UPTC3659_RS06735	COG0840	transmembrane signaling receptor activity
UPTC3659_RS06745	COG0357	Ribosomal RNA small subunit methyltransferase G
UPTC3659_RS06750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UPTC3659_RS06755	COG0113	porphobilinogen synthase activity
UPTC3659_RS06765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UPTC3659_RS06770	COG2181	nitrate reductase activity
UPTC3659_RS06770	COG0247	lactate metabolic process
UPTC3659_RS06780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UPTC3659_RS06800	COG1999	signal sequence binding
UPTC3659_RS06805	COG4591	ABC-type transport system involved in lipoprotein release permease component
UPTC3659_RS06820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UPTC3659_RS06835	COG0471	metal ion transport
UPTC3659_RS06865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UPTC3659_RS06870	COG1280	lysine exporter protein (LysE YggA)
UPTC3659_RS06875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
UPTC3659_RS06880	COG1193	negative regulation of DNA recombination
UPTC3659_RS06910	COG0517	IMP dehydrogenase activity
UPTC3659_RS06910	COG0516	GMP reductase activity
UPTC3659_RS06915	COG0154	amidase activity
UPTC3659_RS06920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
UPTC3659_RS06925	COG1058	Belongs to the CinA family
UPTC3659_RS06925	COG1546	Belongs to the CinA family
UPTC3659_RS06955	COG1136	(ABC) transporter
UPTC3659_RS06955	COG0577	efflux transmembrane transporter activity
UPTC3659_RS06985	COG1301	dicarboxylic acid transport
UPTC3659_RS07010	COG0275	rRNA processing
UPTC3659_RS07025	COG0849	cell division
UPTC3659_RS07030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
UPTC3659_RS07035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
UPTC3659_RS07040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
UPTC3659_RS07045	COG0529	Catalyzes the synthesis of activated sulfate
UPTC3659_RS07055	COG4106	trans-aconitate 2-methyltransferase activity
UPTC3659_RS07060	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UPTC3659_RS07065	COG0574	Belongs to the PEP-utilizing enzyme family
UPTC3659_RS07065	COG3848	Pyruvate phosphate dikinase
UPTC3659_RS07070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
UPTC3659_RS07075	COG1213	nucleotidyl transferase
UPTC3659_RS07080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UPTC3659_RS07115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UPTC3659_RS07120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UPTC3659_RS07130	COG1185	polyribonucleotide nucleotidyltransferase activity
UPTC3659_RS07130	COG0539	negative regulation of cytoplasmic translation
UPTC3659_RS07135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
UPTC3659_RS07140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
UPTC3659_RS07150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UPTC3659_RS07155	COG0537	adenosine 5'-monophosphoramidase activity
UPTC3659_RS07160	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
UPTC3659_RS07170	COG0733	neurotransmitter:sodium symporter activity
UPTC3659_RS07175	COG0733	neurotransmitter:sodium symporter activity
UPTC3659_RS07180	COG0733	neurotransmitter:sodium symporter activity
UPTC3659_RS07185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UPTC3659_RS07210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UPTC3659_RS07215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UPTC3659_RS07230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
UPTC3659_RS07235	COG0552	protein localization to endoplasmic reticulum
UPTC3659_RS07240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UPTC3659_RS07265	COG1295	ribonuclease BN
UPTC3659_RS07280	COG0739	heme binding
UPTC3659_RS07285	COG2239	Acts as a magnesium transporter
UPTC3659_RS07290	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
UPTC3659_RS07295	COG0305	Participates in initiation and elongation during chromosome replication
UPTC3659_RS07300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UPTC3659_RS07305	COG0776	regulation of translation
UPTC3659_RS07315	COG1216	Glycosyl transferase, family 2
UPTC3659_RS07315	COG1442	glycosyl transferase family 8
UPTC3659_RS07325	COG2194	sulfuric ester hydrolase activity
UPTC3659_RS07335	COG1216	Glycosyl transferase, family 2
UPTC3659_RS07335	COG1442	glycosyl transferase family 8
UPTC3659_RS07345	COG1442	glycosyl transferase family 8
UPTC3659_RS07345	COG1216	Glycosyl transferase, family 2
UPTC3659_RS07355	COG1442	glycosyl transferase family 8
UPTC3659_RS07355	COG1216	Glycosyl transferase, family 2
UPTC3659_RS07370	COG0859	PFAM glycosyl transferase family 9
UPTC3659_RS07380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UPTC3659_RS07385	COG1132	(ABC) transporter
UPTC3659_RS07390	COG0438	transferase activity, transferring glycosyl groups
UPTC3659_RS07395	COG0438	transferase activity, transferring glycosyl groups
UPTC3659_RS07400	COG1287	oligosaccharyl transferase activity
UPTC3659_RS07405	COG0438	transferase activity, transferring glycosyl groups
UPTC3659_RS07410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
UPTC3659_RS07415	COG0110	maltose O-acetyltransferase activity
UPTC3659_RS07420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UPTC3659_RS07425	COG1086	Polysaccharide biosynthesis protein
UPTC3659_RS07430	COG0745	RESPONSE REGULATOR receiver
UPTC3659_RS07435	COG2264	protein methyltransferase activity
UPTC3659_RS07440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UPTC3659_RS07450	COG1183	phosphatidylcholine synthase activity
UPTC3659_RS07465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UPTC3659_RS07480	COG1607	acyl-coa hydrolase
UPTC3659_RS07485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UPTC3659_RS07505	COG2255	four-way junction helicase activity
UPTC3659_RS07510	COG0628	permease
UPTC3659_RS07520	COG2814	Major facilitator Superfamily
UPTC3659_RS07525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UPTC3659_RS07560	COG2076	Multidrug Resistance protein
UPTC3659_RS07570	COG1921	L-seryl-tRNASec selenium transferase activity
UPTC3659_RS07575	COG3276	selenocysteine insertion sequence binding
UPTC3659_RS07590	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UPTC3659_RS07595	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
UPTC3659_RS07600	COG0281	malic enzyme
UPTC3659_RS07600	COG0280	phosphate acetyltransferase
UPTC3659_RS07605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UPTC3659_RS07610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UPTC3659_RS07615	COG0439	Biotin carboxylase
UPTC3659_RS07620	COG0511	ligase activity, forming carbon-carbon bonds
UPTC3659_RS07625	COG0717	Belongs to the dCTP deaminase family
UPTC3659_RS07630	COG1086	Polysaccharide biosynthesis protein
UPTC3659_RS07635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UPTC3659_RS07640	COG4310	Domain of unknown function (DUF2172)
UPTC3659_RS07665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UPTC3659_RS07670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UPTC3659_RS07680	COG1028	Short-chain dehydrogenase reductase Sdr
UPTC3659_RS07685	COG1083	cytidylyl-transferase
UPTC3659_RS07705	COG3980	spore coat polysaccharide biosynthesis protein
UPTC3659_RS07710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UPTC3659_RS07720	COG0730	response to heat
UPTC3659_RS07725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UPTC3659_RS07730	COG0840	transmembrane signaling receptor activity
UPTC3659_RS07735	COG0450	alkyl hydroperoxide reductase
UPTC3659_RS07745	COG0105	UTP biosynthetic process
UPTC3659_RS07755	COG0333	Belongs to the bacterial ribosomal protein bL32 family
UPTC3659_RS07760	COG0416	fatty acid biosynthetic process
UPTC3659_RS07770	COG1360	Flagellar Motor Protein
UPTC3659_RS07775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
UPTC3659_RS07785	COG0477	Major facilitator Superfamily
UPTC3659_RS07800	COG0133	tryptophan synthase activity
UPTC3659_RS07810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UPTC3659_RS07815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
UPTC3659_RS07820	COG1570	exodeoxyribonuclease VII activity
UPTC3659_RS07825	COG2226	methyltransferase
UPTC3659_RS07840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UPTC3659_RS07850	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UPTC3659_RS07860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UPTC3659_RS07870	COG0647	UMP catabolic process
UPTC3659_RS07875	COG0019	diaminopimelate decarboxylase activity
UPTC3659_RS07885	COG0193	aminoacyl-tRNA hydrolase activity
UPTC3659_RS07890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
UPTC3659_RS07905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UPTC3659_RS07915	COG0835	chemotaxis
UPTC3659_RS07920	COG0784	Response regulator, receiver
UPTC3659_RS07920	COG2198	Histidine kinase
UPTC3659_RS07920	COG0643	Histidine kinase
UPTC3659_RS07925	COG0835	chemotaxis
UPTC3659_RS07925	COG0784	Response regulator, receiver
UPTC3659_RS07935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UPTC3659_RS07940	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UPTC3659_RS07965	COG2195	Cleaves the N-terminal amino acid of tripeptides
UPTC3659_RS07970	COG3069	C4-dicarboxylate transmembrane transporter activity
UPTC3659_RS07975	COG3340	Belongs to the peptidase S51 family
UPTC3659_RS07980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
UPTC3659_RS08000	COG0500	methyltransferase
UPTC3659_RS08020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UPTC3659_RS08025	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
UPTC3659_RS08030	COG2076	Multidrug Resistance protein
UPTC3659_RS08035	COG2076	Multidrug Resistance protein
UPTC3659_RS08040	COG0840	transmembrane signaling receptor activity
UPTC3659_RS08065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UPTC3659_RS08075	COG1077	Cell shape determining protein MreB Mrl
UPTC3659_RS08080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
UPTC3659_RS08085	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UPTC3659_RS08090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UPTC3659_RS08095	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
UPTC3659_RS08100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UPTC3659_RS08105	COG1942	4-Oxalocrotonate Tautomerase
UPTC3659_RS08115	COG0330	HflC and HflK could
UPTC3659_RS08130	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
UPTC3659_RS08135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
UPTC3659_RS08140	COG0492	ferredoxin-NADP+ reductase activity
UPTC3659_RS08145	COG3118	belongs to the thioredoxin family
UPTC3659_RS08150	COG0792	nuclease activity
UPTC3659_RS08155	COG0460	homoserine dehydrogenase
UPTC3659_RS08160	COG0436	Aminotransferase
UPTC3659_RS08180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
UPTC3659_RS08185	COG0254	rRNA binding
UPTC3659_RS08190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UPTC3659_RS08210	COG0602	queuosine metabolic process
UPTC3659_RS08215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UPTC3659_RS08235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
UPTC3659_RS08245	COG1007	ATP synthesis coupled electron transport
UPTC3659_RS08250	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UPTC3659_RS08255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UPTC3659_RS08265	COG0839	Belongs to the complex I subunit 6 family
UPTC3659_RS08275	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
UPTC3659_RS08300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UPTC3659_RS08305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UPTC3659_RS08310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UPTC3659_RS08315	COG4608	Belongs to the ABC transporter superfamily
UPTC3659_RS08325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UPTC3659_RS08340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
UPTC3659_RS08355	COG2890	protein-(glutamine-N5) methyltransferase activity
UPTC3659_RS08415	COG0861	Integral membrane protein TerC family
UPTC3659_RS08420	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UPTC3659_RS08425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
UPTC3659_RS08425	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
UPTC3659_RS08440	COG0606	chelatase, subunit chli
UPTC3659_RS08445	COG0242	peptide deformylase activity
UPTC3659_RS08455	COG0740	serine-type endopeptidase activity
UPTC3659_RS08460	COG0544	peptidyl-prolyl cis-trans isomerase activity
UPTC3659_RS08465	COG0302	gtp cyclohydrolase
UPTC3659_RS08470	COG1157	protein secretion by the type III secretion system
UPTC3659_RS08500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
UPTC3659_RS08505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
UPTC3659_RS08515	COG2860	membrane
UPTC3659_RS08525	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UPTC3659_RS08535	COG0328	RNA-DNA hybrid ribonuclease activity
UPTC3659_RS08545	COG0358	DNA primase activity
UPTC3659_RS08555	COG0840	transmembrane signaling receptor activity
UPTC3659_RS08560	COG4953	penicillin-binding protein 1C
UPTC3659_RS08580	COG0668	transmembrane transport
UPTC3659_RS08585	COG0288	reversible hydration of carbon dioxide
UPTC3659_RS08590	COG0670	Belongs to the BI1 family
UPTC3659_RS08595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UPTC3659_RS08600	COG0233	cytoplasmic translational termination
UPTC3659_RS08605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UPTC3659_RS08615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UPTC3659_RS08630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UPTC3659_RS08645	COG1217	gtp-binding protein TYPA
UPTC3659_RS08665	COG1749	Flagellar hook protein flgE
UPTC3659_RS08690	COG1840	ABC-type Fe3 transport system, periplasmic component
UPTC3659_RS08705	COG4615	Cyclic peptide transporter
UPTC3659_RS08740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UPTC3659_RS08745	COG0575	Belongs to the CDS family
UPTC3659_RS08765	COG2056	Na+-H+ antiporter family
UPTC3659_RS08770	COG0129	dihydroxy-acid dehydratase activity
UPTC3659_RS08795	COG0840	transmembrane signaling receptor activity
UPTC3659_RS08805	COG1222	aaa ATPase
UPTC3659_RS08815	COG1666	GTP binding
UPTC3659_RS08820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UPTC3659_RS08825	COG0754	glutathionylspermidine amidase activity
UPTC3659_RS08835	COG1280	lysine exporter protein (LysE YggA)
UPTC3659_RS08840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
UPTC3659_RS08875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UPTC3659_RS08880	COG1981	membrane
UPTC3659_RS08890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UPTC3659_RS08900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UPTC3659_RS08900	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
UPTC3659_RS08920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
UPTC3659_RS08930	COG0741	lytic transglycosylase activity
UPTC3659_RS08990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
UPTC3659_RS09055	COG1843	Required for flagellar hook formation. May act as a scaffolding protein