locus-tag	class	description
CLCT_RS00010	COG0592	DNA-directed DNA polymerase activity
CLCT_RS00015	COG0187	DNA topoisomerase II activity
CLCT_RS00020	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CLCT_RS00030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLCT_RS00040	COG2824	Alkylphosphonate utilization operon protein PhnA
CLCT_RS00050	COG0504	CTP synthase activity
CLCT_RS00055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLCT_RS00060	COG0741	lytic transglycosylase activity
CLCT_RS00065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLCT_RS00070	COG0268	Binds directly to 16S ribosomal RNA
CLCT_RS00075	COG1187	pseudouridine synthase activity
CLCT_RS00080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLCT_RS00095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLCT_RS00105	COG0564	pseudouridine synthase activity
CLCT_RS00110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLCT_RS00115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLCT_RS00120	COG1297	OPT oligopeptide transporter protein
CLCT_RS00125	COG1968	undecaprenyl-diphosphatase activity
CLCT_RS00130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLCT_RS00135	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLCT_RS00160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLCT_RS00165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLCT_RS00170	COG1793	dna ligase
CLCT_RS00175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLCT_RS00180	COG1121	(ABC) transporter
CLCT_RS00195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLCT_RS00200	COG0418	dihydroorotase activity
CLCT_RS00215	COG2194	sulfuric ester hydrolase activity
CLCT_RS00220	COG0708	Exodeoxyribonuclease III
CLCT_RS00225	COG1971	Probably functions as a manganese efflux pump
CLCT_RS00240	COG1328	CTP reductase activity
CLCT_RS00245	COG0602	queuosine metabolic process
CLCT_RS00250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLCT_RS00255	COG3069	C4-dicarboxylate transmembrane transporter activity
CLCT_RS00260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLCT_RS00270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLCT_RS00275	COG2992	FlgJ-related protein
CLCT_RS00290	COG0051	transcription antitermination factor activity, RNA binding
CLCT_RS00295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLCT_RS00300	COG0088	Forms part of the polypeptide exit tunnel
CLCT_RS00305	COG0089	rRNA binding
CLCT_RS00310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLCT_RS00315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLCT_RS00320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLCT_RS00325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLCT_RS00330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLCT_RS00335	COG0255	Belongs to the universal ribosomal protein uL29 family
CLCT_RS00340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLCT_RS00345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLCT_RS00350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLCT_RS00355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLCT_RS00360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLCT_RS00365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLCT_RS00370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLCT_RS00375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLCT_RS00380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLCT_RS00385	COG0200	Binds to the 23S rRNA
CLCT_RS00390	COG0201	protein transport
CLCT_RS00395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLCT_RS00400	COG0252	asparaginase activity
CLCT_RS00405	COG1592	Rubrerythrin
CLCT_RS00415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLCT_RS00420	COG1902	pentaerythritol trinitrate reductase activity
CLCT_RS00425	COG0814	amino acid
CLCT_RS00430	COG1760	l-serine dehydratase
CLCT_RS00435	COG0024	Methionine aminopeptidase
CLCT_RS00440	COG0840	transmembrane signaling receptor activity
CLCT_RS00445	COG1858	cytochrome C peroxidase
CLCT_RS00450	COG0477	Major facilitator Superfamily
CLCT_RS00460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLCT_RS00465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLCT_RS00470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLCT_RS00475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLCT_RS00485	COG0203	ribosomal protein L17
CLCT_RS00490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLCT_RS00500	COG0131	Imidazoleglycerol-phosphate dehydratase
CLCT_RS00500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CLCT_RS00515	COG0107	imidazoleglycerol-phosphate synthase activity
CLCT_RS00520	COG0140	phosphoribosyl-ATP diphosphatase activity
CLCT_RS00520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLCT_RS00525	COG1749	Flagellar hook protein flgE
CLCT_RS00530	COG2814	Major facilitator Superfamily
CLCT_RS00535	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CLCT_RS00545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLCT_RS00550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLCT_RS00565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLCT_RS00570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLCT_RS00615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLCT_RS00620	COG0642	Histidine kinase
CLCT_RS00625	COG0745	RESPONSE REGULATOR receiver
CLCT_RS00640	COG1194	a g-specific adenine glycosylase
CLCT_RS00675	COG0569	domain protein
CLCT_RS00685	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CLCT_RS00690	COG1027	Aspartate ammonia-lyase
CLCT_RS00695	COG0840	transmembrane signaling receptor activity
CLCT_RS00700	COG2921	Belongs to the UPF0250 family
CLCT_RS00705	COG0315	cyclic pyranopterin monophosphate synthase activity
CLCT_RS00725	COG2346	COG2346, Truncated hemoglobins
CLCT_RS00740	COG0148	phosphopyruvate hydratase activity
CLCT_RS00745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLCT_RS00755	COG1987	bacterial-type flagellum assembly
CLCT_RS00770	COG1218	3'(2'),5'-bisphosphate nucleotidase
CLCT_RS00775	COG0569	domain protein
CLCT_RS00775	COG0475	glutathione-regulated potassium exporter activity
CLCT_RS00780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLCT_RS00785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLCT_RS00820	COG2089	acid synthase
CLCT_RS00830	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLCT_RS00830	COG1776	CheC inhibitor of MCP methylation
CLCT_RS00845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLCT_RS00850	COG0745	RESPONSE REGULATOR receiver
CLCT_RS00860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLCT_RS00895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLCT_RS00900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLCT_RS00905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLCT_RS00915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLCT_RS00920	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLCT_RS00920	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLCT_RS00925	COG1192	Involved in chromosome partitioning
CLCT_RS00930	COG1475	DNA binding
CLCT_RS00945	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLCT_RS00950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLCT_RS00955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLCT_RS00960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLCT_RS00965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLCT_RS00970	COG0811	peptide transport
CLCT_RS00975	COG0848	biopolymer transport protein
CLCT_RS00990	COG2885	chlorophyll binding
CLCT_RS01005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLCT_RS01010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLCT_RS01015	COG0037	tRNA processing
CLCT_RS01035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLCT_RS01050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLCT_RS01055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLCT_RS01060	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLCT_RS01065	COG0287	Prephenate dehydrogenase
CLCT_RS01075	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CLCT_RS01085	COG0083	homoserine kinase activity
CLCT_RS01095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLCT_RS01105	COG0779	Required for maturation of 30S ribosomal subunits
CLCT_RS01115	COG1401	restriction endodeoxyribonuclease activity
CLCT_RS01125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLCT_RS01125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLCT_RS01130	COG0616	signal peptide processing
CLCT_RS01135	COG0402	S-adenosylhomocysteine deaminase activity
CLCT_RS01140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLCT_RS01145	COG0006	proline dipeptidase activity
CLCT_RS01150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLCT_RS01155	COG1419	protein localization to endoplasmic reticulum
CLCT_RS01160	COG0455	bacterial-type flagellum organization
CLCT_RS01170	COG1191	sigma factor activity
CLCT_RS01175	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLCT_RS01180	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLCT_RS01180	COG1776	CheC inhibitor of MCP methylation
CLCT_RS01185	COG1611	Belongs to the LOG family
CLCT_RS01190	COG0482	sulfurtransferase activity
CLCT_RS01210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CLCT_RS01215	COG2046	Belongs to the sulfate adenylyltransferase family
CLCT_RS01220	COG0745	RESPONSE REGULATOR receiver
CLCT_RS01225	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLCT_RS01225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLCT_RS01230	COG0489	protein tyrosine kinase activity
CLCT_RS01235	COG2171	N-acyltransferase activity
CLCT_RS01245	COG0783	Belongs to the Dps family
CLCT_RS01250	COG0166	Belongs to the GPI family
CLCT_RS01260	COG1739	Uncharacterized protein family UPF0029
CLCT_RS01275	COG0488	(ABC) transporter
CLCT_RS01285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLCT_RS01300	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CLCT_RS01320	COG2855	membrane
CLCT_RS01325	COG0583	DNA-binding transcription factor activity
CLCT_RS01335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLCT_RS01350	COG0736	holo-[acyl-carrier-protein] synthase activity
CLCT_RS01355	COG1580	Controls the rotational direction of flagella during chemotaxis
CLCT_RS01365	COG0753	catalase activity
CLCT_RS01375	COG0165	Argininosuccinate lyase
CLCT_RS01380	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CLCT_RS01390	COG0251	oxidation-reduction process
CLCT_RS01395	COG3069	C4-dicarboxylate transmembrane transporter activity
CLCT_RS01410	COG2079	MmgE PrpD family protein
CLCT_RS01415	COG1918	ferrous iron import across plasma membrane
CLCT_RS01420	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLCT_RS01425	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CLCT_RS01430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLCT_RS01435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLCT_RS01440	COG0825	malonyl-CoA metabolic process
CLCT_RS01450	COG2833	Protein of unknown function (DUF455)
CLCT_RS01475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CLCT_RS01475	COG0517	IMP dehydrogenase activity
CLCT_RS01480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLCT_RS01485	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CLCT_RS01520	COG0572	uridine kinase
CLCT_RS01540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLCT_RS01550	COG0662	Cupin 2, conserved barrel domain protein
CLCT_RS01550	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CLCT_RS01555	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CLCT_RS01570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CLCT_RS01575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLCT_RS01615	COG0195	Participates in both transcription termination and antitermination
CLCT_RS01630	COG2121	Domain of unknown function (DUF374)
CLCT_RS01655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLCT_RS01665	COG1053	succinate dehydrogenase
CLCT_RS01670	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CLCT_RS01685	COG2249	NAD(P)H dehydrogenase (quinone) activity
CLCT_RS01690	COG1733	regulation of RNA biosynthetic process
CLCT_RS01700	COG1064	alcohol dehydrogenase
CLCT_RS01715	COG0732	type I restriction modification DNA specificity domain
CLCT_RS01720	COG3177	Filamentation induced by cAMP protein fic
CLCT_RS01730	COG0303	'Molybdopterin
CLCT_RS01735	COG0314	molybdopterin synthase activity
CLCT_RS01770	COG0243	molybdopterin cofactor binding
CLCT_RS01775	COG3383	formate dehydrogenase (NAD+) activity
CLCT_RS01780	COG0437	4 iron, 4 sulfur cluster binding
CLCT_RS01790	COG0425	Belongs to the sulfur carrier protein TusA family
CLCT_RS01790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLCT_RS01805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLCT_RS01820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLCT_RS01840	COG0505	Belongs to the CarA family
CLCT_RS01915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLCT_RS01920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLCT_RS01930	COG0546	phosphoglycolate phosphatase activity
CLCT_RS01955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLCT_RS01960	COG1459	type II secretion system
CLCT_RS01990	COG3951	Flagellar rod assembly protein muramidase FlgJ
CLCT_RS01995	COG1706	bacterial-type flagellum-dependent cell motility
CLCT_RS02020	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CLCT_RS02040	COG0716	FMN binding
CLCT_RS02045	COG0840	transmembrane signaling receptor activity
CLCT_RS02070	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CLCT_RS02080	COG0126	phosphoglycerate kinase activity
CLCT_RS02085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLCT_RS02120	COG0114	fumarate hydratase activity
CLCT_RS02125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLCT_RS02135	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CLCT_RS02140	COG2252	PERMEase
CLCT_RS02150	COG0243	molybdopterin cofactor binding
CLCT_RS02170	COG4773	Receptor
CLCT_RS02175	COG3022	response to hydroperoxide
CLCT_RS02200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLCT_RS02205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLCT_RS02220	COG0250	Participates in transcription elongation, termination and antitermination
CLCT_RS02225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLCT_RS02230	COG0081	regulation of translation
CLCT_RS02235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLCT_RS02240	COG0222	ribosome binding
CLCT_RS02245	COG0085	RNA polymerase activity
CLCT_RS02250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLCT_RS02260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLCT_RS02265	COG0049	tRNA binding
CLCT_RS02270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLCT_RS02275	COG0748	coenzyme F420 binding
CLCT_RS02280	COG1253	flavin adenine dinucleotide binding
CLCT_RS02285	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CLCT_RS02290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLCT_RS02370	COG0848	biopolymer transport protein
CLCT_RS02375	COG0811	peptide transport
CLCT_RS02380	COG4771	TonB-dependent receptor
CLCT_RS02390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLCT_RS02395	COG2217	Heavy metal translocating P-type atpase
CLCT_RS02410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CLCT_RS02415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLCT_RS02420	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CLCT_RS02420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CLCT_RS02425	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CLCT_RS02430	COG0469	pyruvate kinase activity
CLCT_RS02435	COG0579	oxidoreductase
CLCT_RS02460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLCT_RS02480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLCT_RS02495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLCT_RS02500	COG0484	heat shock protein binding
CLCT_RS02505	COG0745	RESPONSE REGULATOR receiver
CLCT_RS02510	COG0642	Histidine kinase
CLCT_RS02515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CLCT_RS02545	COG0519	Catalyzes the synthesis of GMP from XMP
CLCT_RS02545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLCT_RS02550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLCT_RS02570	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CLCT_RS02580	COG1185	polyribonucleotide nucleotidyltransferase activity
CLCT_RS02655	COG0500	methyltransferase
CLCT_RS02660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLCT_RS02670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CLCT_RS02675	COG0653	protein targeting
CLCT_RS02680	COG2204	response regulator
CLCT_RS02685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLCT_RS02695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLCT_RS02700	COG0731	radical SAM domain protein
CLCT_RS02715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLCT_RS02725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLCT_RS02730	COG1160	GTP binding
CLCT_RS02740	COG2233	PERMEase
CLCT_RS02750	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLCT_RS02755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLCT_RS02760	COG0284	orotidine-5'-phosphate decarboxylase activity
CLCT_RS02770	COG0840	transmembrane signaling receptor activity
CLCT_RS02775	COG0138	bifunctional purine biosynthesis protein purh
CLCT_RS02780	COG0484	heat shock protein binding
CLCT_RS02785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLCT_RS02800	COG0706	membrane insertase activity
CLCT_RS02815	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CLCT_RS02835	COG0824	Thioesterase
CLCT_RS02860	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CLCT_RS02865	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLCT_RS02885	COG0500	methyltransferase
CLCT_RS02900	COG2890	protein-(glutamine-N5) methyltransferase activity
CLCT_RS02910	COG0488	(ABC) transporter
CLCT_RS02915	COG1408	metallophosphoesterase
CLCT_RS02920	COG0688	phosphatidylethanolamine metabolic process
CLCT_RS02925	COG2257	FlhB HrpN YscU SpaS Family
CLCT_RS02950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLCT_RS02965	COG0681	Belongs to the peptidase S26 family
CLCT_RS02975	COG0343	queuine tRNA-ribosyltransferase activity
CLCT_RS02990	COG0439	Biotin carboxylase
CLCT_RS03010	COG0772	Belongs to the SEDS family
CLCT_RS03015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLCT_RS03040	COG0642	Histidine kinase
CLCT_RS03050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLCT_RS03055	COG1126	abc transporter atp-binding protein
CLCT_RS03060	COG0765	amino acid transport
CLCT_RS03065	COG1115	amino acid carrier protein
CLCT_RS03070	COG0751	glycine-tRNA ligase activity
CLCT_RS03075	COG0739	heme binding
CLCT_RS03085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLCT_RS03085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLCT_RS03120	COG0772	Belongs to the SEDS family
CLCT_RS03125	COG0564	pseudouridine synthase activity
CLCT_RS03135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLCT_RS03140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLCT_RS03155	COG0528	UMP kinase activity
CLCT_RS03160	COG1758	RNA polymerase activity
CLCT_RS03165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLCT_RS03170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLCT_RS03200	COG0750	zinc metalloprotease
CLCT_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
CLCT_RS03215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLCT_RS03220	COG0612	Peptidase, M16
CLCT_RS03225	COG0167	dihydroorotate dehydrogenase activity
CLCT_RS03230	COG1132	(ABC) transporter
CLCT_RS03235	COG0215	cysteine-tRNA ligase activity
CLCT_RS03240	COG0728	peptidoglycan biosynthetic process
CLCT_RS03250	COG0632	four-way junction helicase activity
CLCT_RS03255	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLCT_RS03270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLCT_RS03275	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CLCT_RS03280	COG0280	phosphate acetyltransferase
CLCT_RS03285	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLCT_RS03290	COG1464	Belongs to the NlpA lipoprotein family
CLCT_RS03300	COG2011	ABC-type metal ion transport system permease component
CLCT_RS03305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLCT_RS03310	COG0525	valine-tRNA ligase activity
CLCT_RS03320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CLCT_RS03325	COG0563	adenylate kinase activity
CLCT_RS03335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLCT_RS03340	COG0497	DNA recombination
CLCT_RS03350	COG0084	hydrolase, TatD family'
CLCT_RS03355	COG0741	lytic transglycosylase activity
CLCT_RS03355	COG1388	LysM domain
CLCT_RS03360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CLCT_RS03380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLCT_RS03395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLCT_RS03400	COG0805	protein transport
CLCT_RS03415	COG0640	Transcriptional regulator
CLCT_RS03420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLCT_RS03425	COG0494	nUDIX hydrolase
CLCT_RS03430	COG0527	aspartate kinase activity
CLCT_RS03445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLCT_RS03450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLCT_RS03455	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CLCT_RS03460	COG0196	riboflavin kinase activity
CLCT_RS03465	COG2890	protein-(glutamine-N5) methyltransferase activity
CLCT_RS03485	COG0012	GTP binding
CLCT_RS03490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLCT_RS03515	COG2201	protein-glutamate methylesterase activity
CLCT_RS03520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLCT_RS03530	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CLCT_RS03535	COG0612	Peptidase, M16
CLCT_RS03540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLCT_RS03545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLCT_RS03550	COG0765	amino acid transport
CLCT_RS03555	COG0765	amino acid transport
CLCT_RS03570	COG0477	Major facilitator Superfamily
CLCT_RS03580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLCT_RS03590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLCT_RS03595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLCT_RS03600	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLCT_RS03615	COG0326	Molecular chaperone. Has ATPase activity
CLCT_RS03620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLCT_RS03625	COG0204	Acyl-transferase
CLCT_RS03635	COG0047	phosphoribosylformylglycinamidine synthase activity
CLCT_RS03640	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLCT_RS03645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLCT_RS03650	COG0793	Belongs to the peptidase S41A family
CLCT_RS03655	COG0542	response to heat
CLCT_RS03660	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CLCT_RS03665	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CLCT_RS03670	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CLCT_RS03675	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CLCT_RS03685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLCT_RS03710	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CLCT_RS03720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLCT_RS03720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLCT_RS03740	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLCT_RS03775	COG1794	racemase activity, acting on amino acids and derivatives
CLCT_RS03780	COG0582	viral genome integration into host DNA
CLCT_RS03795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLCT_RS03800	COG0303	'Molybdopterin
CLCT_RS03820	COG0163	prenyltransferase activity
CLCT_RS03825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLCT_RS03830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLCT_RS03835	COG0124	histidyl-tRNA synthetase
CLCT_RS03840	COG1166	arginine decarboxylase activity
CLCT_RS03845	COG1045	serine acetyltransferase
CLCT_RS03855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLCT_RS03860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLCT_RS03865	COG1137	ATPase activity
CLCT_RS03870	COG0802	atpase or kinase
CLCT_RS03875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLCT_RS03880	COG0137	argininosuccinate synthase activity
CLCT_RS03885	COG0359	binds to the 23S rRNA
CLCT_RS03890	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CLCT_RS03900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLCT_RS03930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLCT_RS03940	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CLCT_RS03945	COG0181	hydroxymethylbilane synthase activity
CLCT_RS03955	COG0442	prolyl-tRNA aminoacylation
CLCT_RS03960	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLCT_RS03965	COG0142	geranyltranstransferase activity
CLCT_RS03980	COG0546	phosphoglycolate phosphatase activity
CLCT_RS03995	COG0789	Transcriptional regulator
CLCT_RS04000	COG0484	heat shock protein binding
CLCT_RS04005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLCT_RS04010	COG0745	RESPONSE REGULATOR receiver
CLCT_RS04015	COG0642	Histidine kinase
CLCT_RS04020	COG0210	DNA helicase
CLCT_RS04025	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CLCT_RS04030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLCT_RS04040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLCT_RS04045	COG0375	protein maturation
CLCT_RS04050	COG0309	Hydrogenase expression formation protein (HypE)
CLCT_RS04055	COG0409	Hydrogenase expression formation protein
CLCT_RS04060	COG0298	carbon dioxide binding
CLCT_RS04070	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CLCT_RS04075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CLCT_RS04080	COG3340	Belongs to the peptidase S51 family
CLCT_RS04090	COG0534	Mate efflux family protein
CLCT_RS04100	COG0581	inorganic phosphate transmembrane transporter activity
CLCT_RS04110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLCT_RS04115	COG0745	RESPONSE REGULATOR receiver
CLCT_RS04120	COG2205	protein histidine kinase activity
CLCT_RS04125	COG1528	Iron-storage protein
CLCT_RS04135	COG0484	heat shock protein binding
CLCT_RS04150	COG1333	cytochrome c biogenesis protein
CLCT_RS04150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLCT_RS04160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLCT_RS04165	COG0440	acetolactate synthase activity
CLCT_RS04170	COG0028	Belongs to the TPP enzyme family
CLCT_RS04180	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLCT_RS04185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLCT_RS04185	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLCT_RS04195	COG0039	L-malate dehydrogenase activity
CLCT_RS04210	COG1196	nuclear chromosome segregation
CLCT_RS04210	COG1674	ftsk spoiiie
CLCT_RS04215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLCT_RS04245	COG0587	DNA-directed DNA polymerase activity
CLCT_RS04255	COG0693	protein deglycase activity
CLCT_RS04265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLCT_RS04270	COG2957	Belongs to the agmatine deiminase family
CLCT_RS04285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLCT_RS04290	COG1663	tetraacyldisaccharide 4'-kinase activity
CLCT_RS04295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CLCT_RS04300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CLCT_RS04305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLCT_RS04310	COG0765	amino acid transport
CLCT_RS04320	COG2258	MOSC domain
CLCT_RS04325	COG1252	NADH dehydrogenase
CLCT_RS04330	COG0733	neurotransmitter:sodium symporter activity
CLCT_RS04350	COG0191	fructose-bisphosphate aldolase activity
CLCT_RS04355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLCT_RS04360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLCT_RS04365	COG0786	glutamate:sodium symporter activity
CLCT_RS04375	COG0577	efflux transmembrane transporter activity
CLCT_RS04375	COG1136	(ABC) transporter
CLCT_RS04380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLCT_RS04385	COG0778	Nitroreductase
CLCT_RS04395	COG2936	dipeptidyl-peptidase activity
CLCT_RS04405	COG0492	ferredoxin-NADP+ reductase activity
CLCT_RS04410	COG2813	Specifically methylates the guanine in position
CLCT_RS04425	COG0134	indole-3-glycerol-phosphate synthase activity
CLCT_RS04435	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CLCT_RS04450	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CLCT_RS04470	COG0443	Heat shock 70 kDa protein
CLCT_RS04475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLCT_RS04480	COG1420	regulation of RNA biosynthetic process
CLCT_RS04495	COG2404	hydrolase activity, acting on ester bonds
CLCT_RS04500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLCT_RS04505	COG1959	2 iron, 2 sulfur cluster binding
CLCT_RS04510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLCT_RS04515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLCT_RS04515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLCT_RS04520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLCT_RS04535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLCT_RS04540	COG0557	exoribonuclease II activity
CLCT_RS04550	COG0360	Binds together with S18 to 16S ribosomal RNA
CLCT_RS04555	COG0629	single-stranded DNA binding
CLCT_RS04560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLCT_RS04565	COG2095	MarC family integral membrane protein
CLCT_RS04585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLCT_RS04590	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CLCT_RS04600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLCT_RS04620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLCT_RS04630	COG2814	Major facilitator Superfamily
CLCT_RS04640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLCT_RS04645	COG1757	Na H antiporter
CLCT_RS04650	COG4221	oxidoreductase activity
CLCT_RS04655	COG0666	response to abiotic stimulus
CLCT_RS04660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLCT_RS04680	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLCT_RS04700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLCT_RS04720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CLCT_RS04725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLCT_RS04725	COG0512	Glutamine amidotransferase of anthranilate synthase
CLCT_RS04745	COG1393	Belongs to the ArsC family
CLCT_RS04750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CLCT_RS04760	COG0335	large ribosomal subunit rRNA binding
CLCT_RS04765	COG0336	Belongs to the RNA methyltransferase TrmD family
CLCT_RS04770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLCT_RS04775	COG1837	Belongs to the UPF0109 family
CLCT_RS04780	COG0228	four-way junction DNA binding
CLCT_RS04785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLCT_RS04790	COG0564	pseudouridine synthase activity
CLCT_RS04795	COG1519	Transferase
CLCT_RS04805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CLCT_RS04810	COG0752	glycyl-tRNA synthetase alpha subunit
CLCT_RS04820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLCT_RS04825	COG0826	peptidase U32
CLCT_RS04835	COG0174	glutamine synthetase
CLCT_RS04840	COG0788	formyltetrahydrofolate deformylase activity
CLCT_RS04845	COG0617	tRNA 3'-terminal CCA addition
CLCT_RS04860	COG2807	transmembrane transport
CLCT_RS04875	COG3043	anaerobic respiration
CLCT_RS04880	COG0348	domain, Protein
CLCT_RS04885	COG0437	4 iron, 4 sulfur cluster binding
CLCT_RS04890	COG0243	molybdopterin cofactor binding
CLCT_RS04900	COG4786	Flagellar basal body rod
CLCT_RS04905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLCT_RS04910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CLCT_RS04920	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CLCT_RS04935	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLCT_RS04940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLCT_RS04955	COG0840	transmembrane signaling receptor activity
CLCT_RS04965	COG0459	protein refolding
CLCT_RS04970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLCT_RS04990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLCT_RS05000	COG0739	heme binding
CLCT_RS05005	COG0285	dihydrofolate synthase activity
CLCT_RS05020	COG0495	leucyl-tRNA aminoacylation
CLCT_RS05030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLCT_RS05035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLCT_RS05040	COG1862	Preprotein translocase
CLCT_RS05045	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CLCT_RS05050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLCT_RS05055	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CLCT_RS05060	COG0540	Belongs to the ATCase OTCase family
CLCT_RS05075	COG0210	DNA helicase
CLCT_RS05095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLCT_RS05110	COG0542	response to heat
CLCT_RS05115	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CLCT_RS05120	COG1815	bacterial-type flagellum-dependent cell motility
CLCT_RS05125	COG1558	bacterial-type flagellum-dependent cell motility
CLCT_RS05130	COG1677	Flagellar hook-basal body complex protein FliE
CLCT_RS05135	COG0768	penicillin binding
CLCT_RS05140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CLCT_RS05155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLCT_RS05160	COG0424	maF-like protein
CLCT_RS05170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CLCT_RS05180	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CLCT_RS05185	COG2217	Heavy metal translocating P-type atpase
CLCT_RS05200	COG0217	transcriptional regulatory protein
CLCT_RS05205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLCT_RS05215	COG0586	Pfam SNARE associated Golgi protein
CLCT_RS05225	COG3610	response to peptide
CLCT_RS05230	COG0018	arginyl-trna synthetase
CLCT_RS05235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLCT_RS05240	COG0194	GDP metabolic process
CLCT_RS05250	COG1684	flagellar biosynthetic protein fliR
CLCT_RS05255	COG1136	(ABC) transporter
CLCT_RS05260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLCT_RS05265	COG0052	Belongs to the universal ribosomal protein uS2 family
CLCT_RS05280	COG0723	plastoquinol--plastocyanin reductase activity
CLCT_RS05295	COG1496	oxidoreductase activity
CLCT_RS05305	COG0642	Histidine kinase
CLCT_RS05315	COG2703	oxygen carrier activity
CLCT_RS05330	COG4773	Receptor
CLCT_RS05350	COG0683	leucine binding
CLCT_RS05375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLCT_RS05375	COG1333	cytochrome c biogenesis protein
CLCT_RS05385	COG0481	GTPase activity
CLCT_RS05405	COG0352	thiamine-phosphate diphosphorylase activity
CLCT_RS05410	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CLCT_RS05415	COG0351	phosphomethylpyrimidine kinase
CLCT_RS05420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLCT_RS05425	COG0840	transmembrane signaling receptor activity
CLCT_RS05440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLCT_RS05445	COG0113	porphobilinogen synthase activity
CLCT_RS05455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLCT_RS05460	COG0247	lactate metabolic process
CLCT_RS05460	COG2181	nitrate reductase activity
CLCT_RS05470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLCT_RS05490	COG1999	signal sequence binding
CLCT_RS05495	COG4591	ABC-type transport system involved in lipoprotein release permease component
CLCT_RS05510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLCT_RS05525	COG0471	metal ion transport
CLCT_RS05535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLCT_RS05560	COG2865	translation initiation factor activity
CLCT_RS05570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLCT_RS05575	COG1280	lysine exporter protein (LysE YggA)
CLCT_RS05580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CLCT_RS05585	COG1193	negative regulation of DNA recombination
CLCT_RS05620	COG0516	GMP reductase activity
CLCT_RS05620	COG0517	IMP dehydrogenase activity
CLCT_RS05625	COG0154	amidase activity
CLCT_RS05635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLCT_RS05640	COG1546	Belongs to the CinA family
CLCT_RS05640	COG1058	Belongs to the CinA family
CLCT_RS05670	COG0577	efflux transmembrane transporter activity
CLCT_RS05670	COG1136	(ABC) transporter
CLCT_RS05695	COG0672	)-iron permease
CLCT_RS05700	COG1301	dicarboxylic acid transport
CLCT_RS05725	COG0275	rRNA processing
CLCT_RS05740	COG0849	cell division
CLCT_RS05745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CLCT_RS05750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLCT_RS05755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLCT_RS05770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLCT_RS05795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLCT_RS05800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLCT_RS05810	COG1185	polyribonucleotide nucleotidyltransferase activity
CLCT_RS05810	COG0539	negative regulation of cytoplasmic translation
CLCT_RS05815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLCT_RS05820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLCT_RS05830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLCT_RS05835	COG0537	adenosine 5'-monophosphoramidase activity
CLCT_RS05840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CLCT_RS05850	COG0733	neurotransmitter:sodium symporter activity
CLCT_RS05855	COG0733	neurotransmitter:sodium symporter activity
CLCT_RS05860	COG0733	neurotransmitter:sodium symporter activity
CLCT_RS05865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLCT_RS05885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLCT_RS05890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLCT_RS05895	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLCT_RS05910	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLCT_RS05915	COG0552	protein localization to endoplasmic reticulum
CLCT_RS05920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLCT_RS05945	COG1295	ribonuclease BN
CLCT_RS05960	COG0739	heme binding
CLCT_RS05965	COG2239	Acts as a magnesium transporter
CLCT_RS05970	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CLCT_RS05975	COG0305	Participates in initiation and elongation during chromosome replication
CLCT_RS05980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLCT_RS05985	COG0776	regulation of translation
CLCT_RS05995	COG1216	Glycosyl transferase, family 2
CLCT_RS05995	COG1442	glycosyl transferase family 8
CLCT_RS06050	COG1442	glycosyl transferase family 8
CLCT_RS06050	COG1216	Glycosyl transferase, family 2
CLCT_RS06065	COG0859	PFAM glycosyl transferase family 9
CLCT_RS06075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLCT_RS06080	COG1132	(ABC) transporter
CLCT_RS06085	COG0438	transferase activity, transferring glycosyl groups
CLCT_RS06090	COG0438	transferase activity, transferring glycosyl groups
CLCT_RS06095	COG1287	oligosaccharyl transferase activity
CLCT_RS06100	COG0438	transferase activity, transferring glycosyl groups
CLCT_RS06105	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLCT_RS06110	COG0110	maltose O-acetyltransferase activity
CLCT_RS06115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLCT_RS06120	COG1086	Polysaccharide biosynthesis protein
CLCT_RS06125	COG0745	RESPONSE REGULATOR receiver
CLCT_RS06130	COG2264	protein methyltransferase activity
CLCT_RS06135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLCT_RS06145	COG1183	phosphatidylcholine synthase activity
CLCT_RS06160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLCT_RS06175	COG1607	acyl-coa hydrolase
CLCT_RS06180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLCT_RS06205	COG2255	four-way junction helicase activity
CLCT_RS06210	COG0628	permease
CLCT_RS06215	COG2814	Major facilitator Superfamily
CLCT_RS06220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLCT_RS06265	COG1921	L-seryl-tRNASec selenium transferase activity
CLCT_RS06285	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLCT_RS06290	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CLCT_RS06295	COG0281	malic enzyme
CLCT_RS06295	COG0280	phosphate acetyltransferase
CLCT_RS06300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLCT_RS06305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLCT_RS06310	COG0439	Biotin carboxylase
CLCT_RS06315	COG0511	ligase activity, forming carbon-carbon bonds
CLCT_RS06320	COG0717	Belongs to the dCTP deaminase family
CLCT_RS06325	COG1086	Polysaccharide biosynthesis protein
CLCT_RS06330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLCT_RS06335	COG4310	Domain of unknown function (DUF2172)
CLCT_RS06355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLCT_RS06370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLCT_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
CLCT_RS06385	COG1083	cytidylyl-transferase
CLCT_RS06410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLCT_RS06415	COG0107	imidazoleglycerol-phosphate synthase activity
CLCT_RS06420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLCT_RS06430	COG0730	response to heat
CLCT_RS06435	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLCT_RS06440	COG0840	transmembrane signaling receptor activity
CLCT_RS06445	COG0840	transmembrane signaling receptor activity
CLCT_RS06455	COG0450	alkyl hydroperoxide reductase
CLCT_RS06465	COG0105	UTP biosynthetic process
CLCT_RS06475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLCT_RS06480	COG0416	fatty acid biosynthetic process
CLCT_RS06490	COG1360	Flagellar Motor Protein
CLCT_RS06495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CLCT_RS06505	COG0477	Major facilitator Superfamily
CLCT_RS06525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLCT_RS06530	COG1966	Carbon starvation protein
CLCT_RS06540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CLCT_RS06545	COG1570	exodeoxyribonuclease VII activity
CLCT_RS06550	COG2226	methyltransferase
CLCT_RS06565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLCT_RS06575	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLCT_RS06585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLCT_RS06600	COG0019	diaminopimelate decarboxylase activity
CLCT_RS06610	COG0193	aminoacyl-tRNA hydrolase activity
CLCT_RS06615	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLCT_RS06620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLCT_RS06630	COG0835	chemotaxis
CLCT_RS06635	COG2198	Histidine kinase
CLCT_RS06635	COG0784	Response regulator, receiver
CLCT_RS06635	COG0643	Histidine kinase
CLCT_RS06640	COG0835	chemotaxis
CLCT_RS06640	COG0784	Response regulator, receiver
CLCT_RS06650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLCT_RS06655	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLCT_RS06685	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLCT_RS06690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLCT_RS06705	COG0500	methyltransferase
CLCT_RS06725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLCT_RS06730	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CLCT_RS06735	COG2076	Multidrug Resistance protein
CLCT_RS06740	COG2076	Multidrug Resistance protein
CLCT_RS06745	COG1446	asparaginase
CLCT_RS06755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLCT_RS06770	COG1077	Cell shape determining protein MreB Mrl
CLCT_RS06775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLCT_RS06780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLCT_RS06785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLCT_RS06790	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLCT_RS06795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLCT_RS06800	COG1942	4-Oxalocrotonate Tautomerase
CLCT_RS06810	COG0330	HflC and HflK could
CLCT_RS06825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLCT_RS06830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLCT_RS06840	COG0492	ferredoxin-NADP+ reductase activity
CLCT_RS06845	COG3118	belongs to the thioredoxin family
CLCT_RS06850	COG0792	nuclease activity
CLCT_RS06855	COG0460	homoserine dehydrogenase
CLCT_RS06860	COG0436	Aminotransferase
CLCT_RS06880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLCT_RS06885	COG0254	rRNA binding
CLCT_RS06890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLCT_RS06910	COG0602	queuosine metabolic process
CLCT_RS06915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLCT_RS06935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLCT_RS06945	COG1007	ATP synthesis coupled electron transport
CLCT_RS06950	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLCT_RS06955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLCT_RS06965	COG0839	Belongs to the complex I subunit 6 family
CLCT_RS06970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLCT_RS06975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CLCT_RS07005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLCT_RS07010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLCT_RS07015	COG4608	Belongs to the ABC transporter superfamily
CLCT_RS07020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLCT_RS07025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLCT_RS07040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLCT_RS07060	COG2890	protein-(glutamine-N5) methyltransferase activity
CLCT_RS07125	COG0861	Integral membrane protein TerC family
CLCT_RS07130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLCT_RS07135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLCT_RS07135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLCT_RS07150	COG0606	chelatase, subunit chli
CLCT_RS07155	COG0242	peptide deformylase activity
CLCT_RS07165	COG0740	serine-type endopeptidase activity
CLCT_RS07170	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLCT_RS07175	COG0302	gtp cyclohydrolase
CLCT_RS07180	COG1157	protein secretion by the type III secretion system
CLCT_RS07210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CLCT_RS07215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CLCT_RS07225	COG2860	membrane
CLCT_RS07235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLCT_RS07245	COG0328	RNA-DNA hybrid ribonuclease activity
CLCT_RS07255	COG0358	DNA primase activity
CLCT_RS07265	COG0840	transmembrane signaling receptor activity
CLCT_RS07270	COG4953	penicillin-binding protein 1C
CLCT_RS07275	COG2373	Large extracellular alpha-helical protein
CLCT_RS07290	COG0668	transmembrane transport
CLCT_RS07295	COG0288	reversible hydration of carbon dioxide
CLCT_RS07300	COG0670	Belongs to the BI1 family
CLCT_RS07305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLCT_RS07310	COG0233	cytoplasmic translational termination
CLCT_RS07315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLCT_RS07325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLCT_RS07340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CLCT_RS07355	COG1217	gtp-binding protein TYPA
CLCT_RS07375	COG1749	Flagellar hook protein flgE
CLCT_RS07410	COG1840	ABC-type Fe3 transport system, periplasmic component
CLCT_RS07425	COG4615	Cyclic peptide transporter
CLCT_RS07460	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLCT_RS07465	COG0575	Belongs to the CDS family
CLCT_RS07485	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CLCT_RS07490	COG2056	Na+-H+ antiporter family
CLCT_RS07495	COG0129	dihydroxy-acid dehydratase activity
CLCT_RS07525	COG0840	transmembrane signaling receptor activity
CLCT_RS07535	COG1222	aaa ATPase
CLCT_RS07545	COG1666	GTP binding
CLCT_RS07550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLCT_RS07555	COG0754	glutathionylspermidine amidase activity
CLCT_RS07565	COG1280	lysine exporter protein (LysE YggA)
CLCT_RS07570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLCT_RS07605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLCT_RS07610	COG1981	membrane
CLCT_RS07620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLCT_RS07630	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CLCT_RS07630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLCT_RS07655	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group