locus-tag	class	description
F6X58_RS00135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F6X58_RS00295	COG0592	DNA-directed DNA polymerase activity
F6X58_RS00300	COG0187	DNA topoisomerase II activity
F6X58_RS00325	COG0830	nickel cation binding
F6X58_RS00330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F6X58_RS00340	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F6X58_RS00360	COG2824	Alkylphosphonate utilization operon protein PhnA
F6X58_RS00375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F6X58_RS00380	COG0741	lytic transglycosylase activity
F6X58_RS00390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F6X58_RS00395	COG0268	Binds directly to 16S ribosomal RNA
F6X58_RS00400	COG1187	pseudouridine synthase activity
F6X58_RS00415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F6X58_RS00430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F6X58_RS00435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F6X58_RS00450	COG0564	pseudouridine synthase activity
F6X58_RS00455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F6X58_RS00460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F6X58_RS00465	COG1297	OPT oligopeptide transporter protein
F6X58_RS00470	COG1968	undecaprenyl-diphosphatase activity
F6X58_RS00475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F6X58_RS00480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F6X58_RS00490	COG2378	regulation of single-species biofilm formation
F6X58_RS00530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F6X58_RS00535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F6X58_RS00540	COG1793	dna ligase
F6X58_RS00545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F6X58_RS00550	COG1121	(ABC) transporter
F6X58_RS00560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F6X58_RS00570	COG0418	dihydroorotase activity
F6X58_RS00585	COG2194	sulfuric ester hydrolase activity
F6X58_RS00590	COG0708	Exodeoxyribonuclease III
F6X58_RS00595	COG1971	Probably functions as a manganese efflux pump
F6X58_RS00610	COG1328	CTP reductase activity
F6X58_RS00615	COG0602	queuosine metabolic process
F6X58_RS00620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F6X58_RS00640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F6X58_RS00650	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F6X58_RS00655	COG2992	FlgJ-related protein
F6X58_RS00670	COG0051	transcription antitermination factor activity, RNA binding
F6X58_RS00675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F6X58_RS00680	COG0088	Forms part of the polypeptide exit tunnel
F6X58_RS00685	COG0089	rRNA binding
F6X58_RS00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F6X58_RS00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F6X58_RS00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F6X58_RS00705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F6X58_RS00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F6X58_RS00715	COG0255	Belongs to the universal ribosomal protein uL29 family
F6X58_RS00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F6X58_RS00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F6X58_RS00730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F6X58_RS00735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F6X58_RS00740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F6X58_RS00745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F6X58_RS00750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F6X58_RS00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F6X58_RS00760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F6X58_RS00765	COG0200	Binds to the 23S rRNA
F6X58_RS00770	COG0201	protein transport
F6X58_RS00775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F6X58_RS00780	COG0252	asparaginase activity
F6X58_RS00785	COG1592	Rubrerythrin
F6X58_RS00800	COG0814	amino acid
F6X58_RS00805	COG1760	l-serine dehydratase
F6X58_RS00815	COG0024	Methionine aminopeptidase
F6X58_RS00820	COG0840	transmembrane signaling receptor activity
F6X58_RS00825	COG1858	cytochrome C peroxidase
F6X58_RS00830	COG0477	Major facilitator Superfamily
F6X58_RS00840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F6X58_RS00845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F6X58_RS00850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F6X58_RS00855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F6X58_RS00865	COG0203	ribosomal protein L17
F6X58_RS00870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F6X58_RS00880	COG0131	Imidazoleglycerol-phosphate dehydratase
F6X58_RS00880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F6X58_RS00900	COG0107	imidazoleglycerol-phosphate synthase activity
F6X58_RS00905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F6X58_RS00905	COG0140	phosphoribosyl-ATP diphosphatase activity
F6X58_RS00915	COG1749	Flagellar hook protein flgE
F6X58_RS00920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F6X58_RS00925	COG2814	Major facilitator Superfamily
F6X58_RS00930	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F6X58_RS00940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F6X58_RS00945	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F6X58_RS00960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F6X58_RS00965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F6X58_RS01010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F6X58_RS01015	COG0642	Histidine kinase
F6X58_RS01020	COG0745	RESPONSE REGULATOR receiver
F6X58_RS01035	COG1194	a g-specific adenine glycosylase
F6X58_RS01065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F6X58_RS01070	COG1027	Aspartate ammonia-lyase
F6X58_RS01085	COG2921	Belongs to the UPF0250 family
F6X58_RS01090	COG0315	cyclic pyranopterin monophosphate synthase activity
F6X58_RS01110	COG2346	COG2346, Truncated hemoglobins
F6X58_RS01125	COG0148	phosphopyruvate hydratase activity
F6X58_RS01130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F6X58_RS01135	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F6X58_RS01140	COG1987	bacterial-type flagellum assembly
F6X58_RS01155	COG1218	3'(2'),5'-bisphosphate nucleotidase
F6X58_RS01160	COG0569	domain protein
F6X58_RS01160	COG0475	glutathione-regulated potassium exporter activity
F6X58_RS01165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F6X58_RS01170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F6X58_RS01215	COG2089	acid synthase
F6X58_RS01225	COG1776	CheC inhibitor of MCP methylation
F6X58_RS01225	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F6X58_RS01240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F6X58_RS01245	COG0745	RESPONSE REGULATOR receiver
F6X58_RS01255	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F6X58_RS01290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F6X58_RS01295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F6X58_RS01300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F6X58_RS01315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F6X58_RS01320	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F6X58_RS01320	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F6X58_RS01325	COG1192	Involved in chromosome partitioning
F6X58_RS01330	COG1475	DNA binding
F6X58_RS01340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F6X58_RS01345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F6X58_RS01350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F6X58_RS01355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F6X58_RS01360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F6X58_RS01365	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F6X58_RS01370	COG0811	peptide transport
F6X58_RS01375	COG0848	biopolymer transport protein
F6X58_RS01390	COG2885	chlorophyll binding
F6X58_RS01405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F6X58_RS01410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F6X58_RS01435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F6X58_RS01450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F6X58_RS01455	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F6X58_RS01460	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F6X58_RS01465	COG0287	Prephenate dehydrogenase
F6X58_RS01475	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F6X58_RS01485	COG0083	homoserine kinase activity
F6X58_RS01495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F6X58_RS01505	COG0779	Required for maturation of 30S ribosomal subunits
F6X58_RS01510	COG1401	restriction endodeoxyribonuclease activity
F6X58_RS01525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F6X58_RS01525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F6X58_RS01535	COG1404	Belongs to the peptidase S8 family
F6X58_RS01540	COG0402	S-adenosylhomocysteine deaminase activity
F6X58_RS01545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F6X58_RS01550	COG0006	proline dipeptidase activity
F6X58_RS01555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F6X58_RS01560	COG1419	protein localization to endoplasmic reticulum
F6X58_RS01565	COG0455	bacterial-type flagellum organization
F6X58_RS01575	COG1191	sigma factor activity
F6X58_RS01580	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F6X58_RS01585	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F6X58_RS01585	COG1776	CheC inhibitor of MCP methylation
F6X58_RS01590	COG1611	Belongs to the LOG family
F6X58_RS01595	COG0482	sulfurtransferase activity
F6X58_RS01615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F6X58_RS01620	COG2046	Belongs to the sulfate adenylyltransferase family
F6X58_RS01625	COG0745	RESPONSE REGULATOR receiver
F6X58_RS01630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F6X58_RS01630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F6X58_RS01635	COG0489	protein tyrosine kinase activity
F6X58_RS01640	COG2171	N-acyltransferase activity
F6X58_RS01650	COG0783	Belongs to the Dps family
F6X58_RS01655	COG0166	Belongs to the GPI family
F6X58_RS01665	COG1739	Uncharacterized protein family UPF0029
F6X58_RS01680	COG0488	(ABC) transporter
F6X58_RS01690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F6X58_RS01705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F6X58_RS01720	COG2855	membrane
F6X58_RS01725	COG0583	DNA-binding transcription factor activity
F6X58_RS01735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F6X58_RS01750	COG0736	holo-[acyl-carrier-protein] synthase activity
F6X58_RS01755	COG1580	Controls the rotational direction of flagella during chemotaxis
F6X58_RS01765	COG0753	catalase activity
F6X58_RS01775	COG0165	Argininosuccinate lyase
F6X58_RS01780	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F6X58_RS01790	COG0251	oxidation-reduction process
F6X58_RS01795	COG3069	C4-dicarboxylate transmembrane transporter activity
F6X58_RS01810	COG2079	MmgE PrpD family protein
F6X58_RS01815	COG1918	ferrous iron import across plasma membrane
F6X58_RS01820	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F6X58_RS01825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F6X58_RS01830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F6X58_RS01835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F6X58_RS01840	COG0825	malonyl-CoA metabolic process
F6X58_RS01850	COG2833	Protein of unknown function (DUF455)
F6X58_RS01880	COG0517	IMP dehydrogenase activity
F6X58_RS01880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F6X58_RS01890	COG1442	glycosyl transferase family 8
F6X58_RS01890	COG1216	Glycosyl transferase, family 2
F6X58_RS01895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F6X58_RS01895	COG1215	transferase activity, transferring glycosyl groups
F6X58_RS01915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F6X58_RS01920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F6X58_RS01935	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F6X58_RS01945	COG0175	sulfate reduction
F6X58_RS01950	COG2895	sulfate adenylyltransferase (ATP) activity
F6X58_RS01955	COG3273	potassium ion transport
F6X58_RS01955	COG0471	metal ion transport
F6X58_RS01960	COG0529	Catalyzes the synthesis of activated sulfate
F6X58_RS02000	COG0195	Participates in both transcription termination and antitermination
F6X58_RS02015	COG2121	Domain of unknown function (DUF374)
F6X58_RS02040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F6X58_RS02050	COG1053	succinate dehydrogenase
F6X58_RS02055	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F6X58_RS02100	COG1733	regulation of RNA biosynthetic process
F6X58_RS02110	COG1064	alcohol dehydrogenase
F6X58_RS02135	COG1204	response to ionizing radiation
F6X58_RS02160	COG0314	molybdopterin synthase activity
F6X58_RS02190	COG0243	molybdopterin cofactor binding
F6X58_RS02195	COG3383	formate dehydrogenase (NAD+) activity
F6X58_RS02200	COG0437	4 iron, 4 sulfur cluster binding
F6X58_RS02210	COG0425	Belongs to the sulfur carrier protein TusA family
F6X58_RS02225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F6X58_RS02230	COG0384	phenazine biosynthesis protein PhzF
F6X58_RS02240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F6X58_RS02260	COG0505	Belongs to the CarA family
F6X58_RS02315	COG1074	ATP-dependent DNA helicase activity
F6X58_RS02325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F6X58_RS02330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F6X58_RS02340	COG0546	phosphoglycolate phosphatase activity
F6X58_RS02365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F6X58_RS02370	COG1459	type II secretion system
F6X58_RS02385	COG0730	response to heat
F6X58_RS02410	COG3951	Flagellar rod assembly protein muramidase FlgJ
F6X58_RS02415	COG1706	bacterial-type flagellum-dependent cell motility
F6X58_RS02440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F6X58_RS02460	COG0716	FMN binding
F6X58_RS02465	COG0840	transmembrane signaling receptor activity
F6X58_RS02490	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
F6X58_RS02500	COG0126	phosphoglycerate kinase activity
F6X58_RS02505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F6X58_RS02555	COG0114	fumarate hydratase activity
F6X58_RS02560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F6X58_RS02570	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F6X58_RS02575	COG2252	PERMEase
F6X58_RS02585	COG0243	molybdopterin cofactor binding
F6X58_RS02605	COG4773	Receptor
F6X58_RS02610	COG3022	response to hydroperoxide
F6X58_RS02635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F6X58_RS02640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F6X58_RS02655	COG0250	Participates in transcription elongation, termination and antitermination
F6X58_RS02660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F6X58_RS02665	COG0081	regulation of translation
F6X58_RS02670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F6X58_RS02675	COG0222	ribosome binding
F6X58_RS02680	COG0085	RNA polymerase activity
F6X58_RS02685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F6X58_RS02695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F6X58_RS02700	COG0049	tRNA binding
F6X58_RS02705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F6X58_RS02715	COG1253	flavin adenine dinucleotide binding
F6X58_RS02720	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
F6X58_RS02725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F6X58_RS02800	COG0848	biopolymer transport protein
F6X58_RS02805	COG0811	peptide transport
F6X58_RS02810	COG4771	TonB-dependent receptor
F6X58_RS02820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F6X58_RS02825	COG2217	Heavy metal translocating P-type atpase
F6X58_RS02840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F6X58_RS02855	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F6X58_RS02865	COG0579	oxidoreductase
F6X58_RS02870	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F6X58_RS02885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F6X58_RS02905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F6X58_RS02920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F6X58_RS02925	COG0484	heat shock protein binding
F6X58_RS02930	COG0745	RESPONSE REGULATOR receiver
F6X58_RS02935	COG0642	Histidine kinase
F6X58_RS02940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F6X58_RS02965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F6X58_RS02965	COG0519	Catalyzes the synthesis of GMP from XMP
F6X58_RS02970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F6X58_RS02990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F6X58_RS03000	COG1185	polyribonucleotide nucleotidyltransferase activity
F6X58_RS03085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F6X58_RS03095	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F6X58_RS03100	COG0653	protein targeting
F6X58_RS03105	COG2204	response regulator
F6X58_RS03110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F6X58_RS03120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F6X58_RS03125	COG0731	radical SAM domain protein
F6X58_RS03145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F6X58_RS03155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F6X58_RS03160	COG1160	GTP binding
F6X58_RS03170	COG2233	PERMEase
F6X58_RS03180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F6X58_RS03185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F6X58_RS03190	COG0284	orotidine-5'-phosphate decarboxylase activity
F6X58_RS03200	COG0840	transmembrane signaling receptor activity
F6X58_RS03205	COG0138	bifunctional purine biosynthesis protein purh
F6X58_RS03210	COG0484	heat shock protein binding
F6X58_RS03215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F6X58_RS03230	COG0706	membrane insertase activity
F6X58_RS03245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F6X58_RS03265	COG0824	Thioesterase
F6X58_RS03270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F6X58_RS03290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F6X58_RS03295	COG2195	Cleaves the N-terminal amino acid of tripeptides
F6X58_RS03315	COG0500	methyltransferase
F6X58_RS03330	COG2890	protein-(glutamine-N5) methyltransferase activity
F6X58_RS03345	COG0488	(ABC) transporter
F6X58_RS03350	COG1408	metallophosphoesterase
F6X58_RS03355	COG0688	phosphatidylethanolamine metabolic process
F6X58_RS03360	COG2257	FlhB HrpN YscU SpaS Family
F6X58_RS03385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F6X58_RS03400	COG0681	Belongs to the peptidase S26 family
F6X58_RS03410	COG0343	queuine tRNA-ribosyltransferase activity
F6X58_RS03425	COG0439	Biotin carboxylase
F6X58_RS03445	COG0772	Belongs to the SEDS family
F6X58_RS03450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F6X58_RS03455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F6X58_RS03475	COG0642	Histidine kinase
F6X58_RS03485	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F6X58_RS03490	COG1126	abc transporter atp-binding protein
F6X58_RS03495	COG0765	amino acid transport
F6X58_RS03500	COG1115	amino acid carrier protein
F6X58_RS03505	COG0751	glycine-tRNA ligase activity
F6X58_RS03510	COG0739	heme binding
F6X58_RS03520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F6X58_RS03520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F6X58_RS03540	COG0772	Belongs to the SEDS family
F6X58_RS03545	COG0564	pseudouridine synthase activity
F6X58_RS03555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F6X58_RS03560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F6X58_RS03575	COG0528	UMP kinase activity
F6X58_RS03580	COG1758	RNA polymerase activity
F6X58_RS03585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F6X58_RS03590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F6X58_RS03630	COG0750	zinc metalloprotease
F6X58_RS03640	COG1028	Short-chain dehydrogenase reductase Sdr
F6X58_RS03645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F6X58_RS03650	COG0612	Peptidase, M16
F6X58_RS03655	COG0167	dihydroorotate dehydrogenase activity
F6X58_RS03660	COG1132	(ABC) transporter
F6X58_RS03665	COG0215	cysteine-tRNA ligase activity
F6X58_RS03670	COG0728	peptidoglycan biosynthetic process
F6X58_RS03680	COG0632	four-way junction helicase activity
F6X58_RS03685	COG1181	Belongs to the D-alanine--D-alanine ligase family
F6X58_RS03705	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F6X58_RS03710	COG0280	phosphate acetyltransferase
F6X58_RS03715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F6X58_RS03720	COG1464	Belongs to the NlpA lipoprotein family
F6X58_RS03730	COG2011	ABC-type metal ion transport system permease component
F6X58_RS03735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F6X58_RS03750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F6X58_RS03755	COG0563	adenylate kinase activity
F6X58_RS03765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F6X58_RS03770	COG0497	DNA recombination
F6X58_RS03780	COG0084	hydrolase, TatD family'
F6X58_RS03785	COG1388	LysM domain
F6X58_RS03785	COG0741	lytic transglycosylase activity
F6X58_RS03790	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F6X58_RS03810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F6X58_RS03825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F6X58_RS03830	COG0805	protein transport
F6X58_RS03840	COG0500	methyltransferase
F6X58_RS03845	COG0500	methyltransferase
F6X58_RS03850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F6X58_RS03860	COG0527	aspartate kinase activity
F6X58_RS03875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F6X58_RS03880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F6X58_RS03885	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F6X58_RS03890	COG0196	riboflavin kinase activity
F6X58_RS03895	COG2890	protein-(glutamine-N5) methyltransferase activity
F6X58_RS03915	COG0012	GTP binding
F6X58_RS03920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F6X58_RS03940	COG0698	ribose 5-phosphate isomerase
F6X58_RS03945	COG2201	protein-glutamate methylesterase activity
F6X58_RS03950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F6X58_RS03960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F6X58_RS03965	COG0612	Peptidase, M16
F6X58_RS03970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F6X58_RS03975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F6X58_RS03980	COG0765	amino acid transport
F6X58_RS03985	COG0765	amino acid transport
F6X58_RS04000	COG0477	Major facilitator Superfamily
F6X58_RS04030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F6X58_RS04040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F6X58_RS04050	COG0521	Mo-molybdopterin cofactor biosynthetic process
F6X58_RS04065	COG0326	Molecular chaperone. Has ATPase activity
F6X58_RS04070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F6X58_RS04075	COG0204	Acyl-transferase
F6X58_RS04085	COG0047	phosphoribosylformylglycinamidine synthase activity
F6X58_RS04090	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F6X58_RS04095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F6X58_RS04100	COG0793	Belongs to the peptidase S41A family
F6X58_RS04105	COG0542	response to heat
F6X58_RS04110	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
F6X58_RS04115	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
F6X58_RS04120	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
F6X58_RS04125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
F6X58_RS04160	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F6X58_RS04170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6X58_RS04170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F6X58_RS04225	COG1794	racemase activity, acting on amino acids and derivatives
F6X58_RS04230	COG0582	viral genome integration into host DNA
F6X58_RS04245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F6X58_RS04250	COG0303	'Molybdopterin
F6X58_RS04290	COG0163	prenyltransferase activity
F6X58_RS04295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F6X58_RS04300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F6X58_RS04305	COG0124	histidyl-tRNA synthetase
F6X58_RS04310	COG1166	arginine decarboxylase activity
F6X58_RS04325	COG1045	serine acetyltransferase
F6X58_RS04335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F6X58_RS04340	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F6X58_RS04345	COG1137	ATPase activity
F6X58_RS04350	COG0802	atpase or kinase
F6X58_RS04355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F6X58_RS04360	COG0137	argininosuccinate synthase activity
F6X58_RS04365	COG0359	binds to the 23S rRNA
F6X58_RS04370	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F6X58_RS04380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F6X58_RS04410	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
F6X58_RS04420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F6X58_RS04425	COG0181	hydroxymethylbilane synthase activity
F6X58_RS04435	COG0442	prolyl-tRNA aminoacylation
F6X58_RS04440	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F6X58_RS04445	COG0142	geranyltranstransferase activity
F6X58_RS04460	COG0546	phosphoglycolate phosphatase activity
F6X58_RS04470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F6X58_RS04470	COG0475	glutathione-regulated potassium exporter activity
F6X58_RS04475	COG0789	Transcriptional regulator
F6X58_RS04480	COG0484	heat shock protein binding
F6X58_RS04485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F6X58_RS04490	COG0745	RESPONSE REGULATOR receiver
F6X58_RS04495	COG0642	Histidine kinase
F6X58_RS04500	COG0210	DNA helicase
F6X58_RS04505	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F6X58_RS04520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F6X58_RS04525	COG0375	protein maturation
F6X58_RS04530	COG0309	Hydrogenase expression formation protein (HypE)
F6X58_RS04535	COG0409	Hydrogenase expression formation protein
F6X58_RS04540	COG0298	carbon dioxide binding
F6X58_RS04550	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
F6X58_RS04555	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
F6X58_RS04560	COG3340	Belongs to the peptidase S51 family
F6X58_RS04570	COG0534	Mate efflux family protein
F6X58_RS04590	COG1213	nucleotidyl transferase
F6X58_RS04595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F6X58_RS04600	COG3848	Pyruvate phosphate dikinase
F6X58_RS04600	COG0574	Belongs to the PEP-utilizing enzyme family
F6X58_RS04605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F6X58_RS04610	COG4106	trans-aconitate 2-methyltransferase activity
F6X58_RS04615	COG0529	Catalyzes the synthesis of activated sulfate
F6X58_RS04630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F6X58_RS04650	COG0581	inorganic phosphate transmembrane transporter activity
F6X58_RS04655	COG0573	inorganic phosphate transmembrane transporter activity
F6X58_RS04660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F6X58_RS04665	COG0745	RESPONSE REGULATOR receiver
F6X58_RS04675	COG1528	Iron-storage protein
F6X58_RS04685	COG0484	heat shock protein binding
F6X58_RS04700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F6X58_RS04700	COG1333	cytochrome c biogenesis protein
F6X58_RS04710	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6X58_RS04715	COG0440	acetolactate synthase activity
F6X58_RS04720	COG0028	Belongs to the TPP enzyme family
F6X58_RS04730	COG1013	pyruvate-flavodoxin oxidoreductase activity
F6X58_RS04735	COG0674	pyruvate-flavodoxin oxidoreductase activity
F6X58_RS04735	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F6X58_RS04745	COG0039	L-malate dehydrogenase activity
F6X58_RS04760	COG1674	ftsk spoiiie
F6X58_RS04760	COG1196	nuclear chromosome segregation
F6X58_RS04765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F6X58_RS04800	COG3561	AntA/AntB antirepressor
F6X58_RS04885	COG3501	Rhs element vgr protein
F6X58_RS05095	COG0587	DNA-directed DNA polymerase activity
F6X58_RS05105	COG0693	protein deglycase activity
F6X58_RS05135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F6X58_RS05140	COG1663	tetraacyldisaccharide 4'-kinase activity
F6X58_RS05145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F6X58_RS05150	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F6X58_RS05155	COG0456	acetyltransferase
F6X58_RS05160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F6X58_RS05165	COG0765	amino acid transport
F6X58_RS05180	COG1252	NADH dehydrogenase
F6X58_RS05185	COG0733	neurotransmitter:sodium symporter activity
F6X58_RS05210	COG0191	fructose-bisphosphate aldolase activity
F6X58_RS05215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F6X58_RS05220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F6X58_RS05225	COG0786	glutamate:sodium symporter activity
F6X58_RS05235	COG0577	efflux transmembrane transporter activity
F6X58_RS05235	COG1136	(ABC) transporter
F6X58_RS05240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F6X58_RS05245	COG0778	Nitroreductase
F6X58_RS05255	COG2936	dipeptidyl-peptidase activity
F6X58_RS05270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F6X58_RS05285	COG0134	indole-3-glycerol-phosphate synthase activity
F6X58_RS05295	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
F6X58_RS05310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F6X58_RS05340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F6X58_RS05345	COG1420	regulation of RNA biosynthetic process
F6X58_RS05360	COG2404	hydrolase activity, acting on ester bonds
F6X58_RS05365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F6X58_RS05370	COG1959	2 iron, 2 sulfur cluster binding
F6X58_RS05375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F6X58_RS05385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F6X58_RS05400	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F6X58_RS05405	COG0557	exoribonuclease II activity
F6X58_RS05415	COG0360	Binds together with S18 to 16S ribosomal RNA
F6X58_RS05420	COG0629	single-stranded DNA binding
F6X58_RS05425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F6X58_RS05430	COG2095	MarC family integral membrane protein
F6X58_RS05450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F6X58_RS05455	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
F6X58_RS05465	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F6X58_RS05470	COG0840	transmembrane signaling receptor activity
F6X58_RS05485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F6X58_RS05495	COG2814	Major facilitator Superfamily
F6X58_RS05505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F6X58_RS05510	COG1757	Na H antiporter
F6X58_RS05520	COG0666	response to abiotic stimulus
F6X58_RS05525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F6X58_RS05540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F6X58_RS05560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F6X58_RS05570	COG1338	Plays a role in the flagellum-specific transport system
F6X58_RS05580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F6X58_RS05585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F6X58_RS05585	COG0512	Glutamine amidotransferase of anthranilate synthase
F6X58_RS05610	COG1393	Belongs to the ArsC family
F6X58_RS05615	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F6X58_RS05625	COG0335	large ribosomal subunit rRNA binding
F6X58_RS05640	COG1837	Belongs to the UPF0109 family
F6X58_RS05645	COG0228	four-way junction DNA binding
F6X58_RS05650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F6X58_RS05655	COG0564	pseudouridine synthase activity
F6X58_RS05660	COG1519	Transferase
F6X58_RS05670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F6X58_RS05675	COG0752	glycyl-tRNA synthetase alpha subunit
F6X58_RS05685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F6X58_RS05690	COG0826	peptidase U32
F6X58_RS05700	COG0174	glutamine synthetase
F6X58_RS05705	COG0788	formyltetrahydrofolate deformylase activity
F6X58_RS05710	COG0617	tRNA 3'-terminal CCA addition
F6X58_RS05725	COG2807	transmembrane transport
F6X58_RS05735	COG4786	Flagellar basal body rod
F6X58_RS05740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F6X58_RS05745	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F6X58_RS05755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F6X58_RS05760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F6X58_RS05790	COG0459	protein refolding
F6X58_RS05795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F6X58_RS05805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F6X58_RS05815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F6X58_RS05825	COG0739	heme binding
F6X58_RS05830	COG0285	dihydrofolate synthase activity
F6X58_RS05845	COG0495	leucyl-tRNA aminoacylation
F6X58_RS05855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F6X58_RS05860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F6X58_RS05865	COG1862	Preprotein translocase
F6X58_RS05870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F6X58_RS05875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F6X58_RS05880	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
F6X58_RS05885	COG0540	Belongs to the ATCase OTCase family
F6X58_RS05900	COG0210	DNA helicase
F6X58_RS05920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F6X58_RS05935	COG0542	response to heat
F6X58_RS05940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F6X58_RS05945	COG1815	bacterial-type flagellum-dependent cell motility
F6X58_RS05950	COG1558	bacterial-type flagellum-dependent cell motility
F6X58_RS05955	COG1677	Flagellar hook-basal body complex protein FliE
F6X58_RS05960	COG0768	penicillin binding
F6X58_RS05970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F6X58_RS05975	COG0673	inositol 2-dehydrogenase activity
F6X58_RS05985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F6X58_RS05990	COG0424	maF-like protein
F6X58_RS06000	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F6X58_RS06010	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F6X58_RS06020	COG2217	Heavy metal translocating P-type atpase
F6X58_RS06045	COG0217	transcriptional regulatory protein
F6X58_RS06050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F6X58_RS06060	COG0586	Pfam SNARE associated Golgi protein
F6X58_RS06070	COG3610	response to peptide
F6X58_RS06075	COG0018	arginyl-trna synthetase
F6X58_RS06080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F6X58_RS06085	COG0194	GDP metabolic process
F6X58_RS06095	COG1684	flagellar biosynthetic protein fliR
F6X58_RS06100	COG1136	(ABC) transporter
F6X58_RS06105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F6X58_RS06110	COG0052	Belongs to the universal ribosomal protein uS2 family
F6X58_RS06125	COG0723	plastoquinol--plastocyanin reductase activity
F6X58_RS06155	COG1496	oxidoreductase activity
F6X58_RS06165	COG0642	Histidine kinase
F6X58_RS06190	COG4773	Receptor
F6X58_RS06230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F6X58_RS06230	COG1333	cytochrome c biogenesis protein
F6X58_RS06240	COG0481	GTPase activity
F6X58_RS06265	COG0352	thiamine-phosphate diphosphorylase activity
F6X58_RS06270	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
F6X58_RS06275	COG0351	phosphomethylpyrimidine kinase
F6X58_RS06280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F6X58_RS06285	COG0840	transmembrane signaling receptor activity
F6X58_RS06295	COG0357	Ribosomal RNA small subunit methyltransferase G
F6X58_RS06300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F6X58_RS06305	COG0113	porphobilinogen synthase activity
F6X58_RS06315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F6X58_RS06330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F6X58_RS06355	COG4591	ABC-type transport system involved in lipoprotein release permease component
F6X58_RS06370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F6X58_RS06385	COG0471	metal ion transport
F6X58_RS06425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F6X58_RS06430	COG1280	lysine exporter protein (LysE YggA)
F6X58_RS06435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F6X58_RS06450	COG1193	negative regulation of DNA recombination
F6X58_RS06485	COG0516	GMP reductase activity
F6X58_RS06485	COG0517	IMP dehydrogenase activity
F6X58_RS06490	COG0154	amidase activity
F6X58_RS06495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F6X58_RS06500	COG1546	Belongs to the CinA family
F6X58_RS06500	COG1058	Belongs to the CinA family
F6X58_RS06525	COG1136	(ABC) transporter
F6X58_RS06525	COG0577	efflux transmembrane transporter activity
F6X58_RS06550	COG0672	)-iron permease
F6X58_RS06555	COG1301	dicarboxylic acid transport
F6X58_RS06580	COG0275	rRNA processing
F6X58_RS06595	COG0849	cell division
F6X58_RS06600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F6X58_RS06605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F6X58_RS06610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F6X58_RS06620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F6X58_RS06650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F6X58_RS06655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F6X58_RS06665	COG1185	polyribonucleotide nucleotidyltransferase activity
F6X58_RS06665	COG0539	negative regulation of cytoplasmic translation
F6X58_RS06670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F6X58_RS06675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F6X58_RS06685	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F6X58_RS06690	COG0537	adenosine 5'-monophosphoramidase activity
F6X58_RS06695	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F6X58_RS06705	COG0733	neurotransmitter:sodium symporter activity
F6X58_RS06710	COG0733	neurotransmitter:sodium symporter activity
F6X58_RS06715	COG0733	neurotransmitter:sodium symporter activity
F6X58_RS06720	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F6X58_RS06740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F6X58_RS06745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F6X58_RS06750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F6X58_RS06760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F6X58_RS06770	COG0552	protein localization to endoplasmic reticulum
F6X58_RS06775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F6X58_RS06785	COG1418	mRNA catabolic process
F6X58_RS06800	COG1295	ribonuclease BN
F6X58_RS06805	COG0277	FAD linked oxidase domain protein
F6X58_RS06815	COG0739	heme binding
F6X58_RS06820	COG2239	Acts as a magnesium transporter
F6X58_RS06825	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F6X58_RS06830	COG0305	Participates in initiation and elongation during chromosome replication
F6X58_RS06835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F6X58_RS06840	COG0776	regulation of translation
F6X58_RS06865	COG1216	Glycosyl transferase, family 2
F6X58_RS06865	COG1442	glycosyl transferase family 8
F6X58_RS06880	COG1028	Short-chain dehydrogenase reductase Sdr
F6X58_RS06885	COG1083	cytidylyl-transferase
F6X58_RS06895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F6X58_RS06900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F6X58_RS06905	COG2089	acid synthase
F6X58_RS06935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F6X58_RS06950	COG0463	Glycosyl transferase, family 2
F6X58_RS06955	COG1216	Glycosyl transferase, family 2
F6X58_RS06960	COG1216	Glycosyl transferase, family 2
F6X58_RS06960	COG1442	glycosyl transferase family 8
F6X58_RS06970	COG1442	glycosyl transferase family 8
F6X58_RS06970	COG1216	Glycosyl transferase, family 2
F6X58_RS06985	COG0859	PFAM glycosyl transferase family 9
F6X58_RS06995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F6X58_RS07000	COG1132	(ABC) transporter
F6X58_RS07005	COG0438	transferase activity, transferring glycosyl groups
F6X58_RS07010	COG0438	transferase activity, transferring glycosyl groups
F6X58_RS07015	COG1287	oligosaccharyl transferase activity
F6X58_RS07020	COG0438	transferase activity, transferring glycosyl groups
F6X58_RS07025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F6X58_RS07030	COG0110	maltose O-acetyltransferase activity
F6X58_RS07035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F6X58_RS07040	COG1086	Polysaccharide biosynthesis protein
F6X58_RS07045	COG0745	RESPONSE REGULATOR receiver
F6X58_RS07050	COG2264	protein methyltransferase activity
F6X58_RS07055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F6X58_RS07065	COG1183	phosphatidylcholine synthase activity
F6X58_RS07080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F6X58_RS07095	COG1607	acyl-coa hydrolase
F6X58_RS07100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F6X58_RS07110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F6X58_RS07120	COG1028	Short-chain dehydrogenase reductase Sdr
F6X58_RS07140	COG2255	four-way junction helicase activity
F6X58_RS07145	COG0628	permease
F6X58_RS07155	COG2814	Major facilitator Superfamily
F6X58_RS07160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F6X58_RS07175	COG2853	Lipoprotein
F6X58_RS07200	COG1921	L-seryl-tRNASec selenium transferase activity
F6X58_RS07220	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
F6X58_RS07225	COG0280	phosphate acetyltransferase
F6X58_RS07225	COG0281	malic enzyme
F6X58_RS07230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F6X58_RS07235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F6X58_RS07240	COG0439	Biotin carboxylase
F6X58_RS07245	COG0511	ligase activity, forming carbon-carbon bonds
F6X58_RS07250	COG0717	Belongs to the dCTP deaminase family
F6X58_RS07255	COG1086	Polysaccharide biosynthesis protein
F6X58_RS07260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F6X58_RS07265	COG4310	Domain of unknown function (DUF2172)
F6X58_RS07275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F6X58_RS07300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F6X58_RS07325	COG1083	cytidylyl-transferase
F6X58_RS07345	COG3980	spore coat polysaccharide biosynthesis protein
F6X58_RS07350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F6X58_RS07365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F6X58_RS07370	COG0107	imidazoleglycerol-phosphate synthase activity
F6X58_RS07375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F6X58_RS07385	COG0730	response to heat
F6X58_RS07390	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F6X58_RS07395	COG0840	transmembrane signaling receptor activity
F6X58_RS07405	COG0840	transmembrane signaling receptor activity
F6X58_RS07410	COG0450	alkyl hydroperoxide reductase
F6X58_RS07420	COG0105	UTP biosynthetic process
F6X58_RS07430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F6X58_RS07435	COG0416	fatty acid biosynthetic process
F6X58_RS07445	COG1360	Flagellar Motor Protein
F6X58_RS07450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F6X58_RS07460	COG0477	Major facilitator Superfamily
F6X58_RS07475	COG0133	tryptophan synthase activity
F6X58_RS07480	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F6X58_RS07485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F6X58_RS07490	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F6X58_RS07495	COG1570	exodeoxyribonuclease VII activity
F6X58_RS07500	COG2226	methyltransferase
F6X58_RS07515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F6X58_RS07525	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F6X58_RS07535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F6X58_RS07540	COG1605	Chorismate mutase
F6X58_RS07540	COG0077	Prephenate dehydratase
F6X58_RS07550	COG0019	diaminopimelate decarboxylase activity
F6X58_RS07560	COG0193	aminoacyl-tRNA hydrolase activity
F6X58_RS07565	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F6X58_RS07580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F6X58_RS07590	COG0835	chemotaxis
F6X58_RS07595	COG0784	Response regulator, receiver
F6X58_RS07595	COG0643	Histidine kinase
F6X58_RS07595	COG2198	Histidine kinase
F6X58_RS07600	COG0784	Response regulator, receiver
F6X58_RS07600	COG0835	chemotaxis
F6X58_RS07610	COG2194	sulfuric ester hydrolase activity
F6X58_RS07615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F6X58_RS07620	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6X58_RS07630	COG0725	ABC transporter, periplasmic molybdate-binding protein
F6X58_RS07650	COG2195	Cleaves the N-terminal amino acid of tripeptides
F6X58_RS07655	COG3069	C4-dicarboxylate transmembrane transporter activity
F6X58_RS07660	COG3340	Belongs to the peptidase S51 family
F6X58_RS07665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F6X58_RS07700	COG0500	methyltransferase
F6X58_RS07720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F6X58_RS07725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F6X58_RS07730	COG2076	Multidrug Resistance protein
F6X58_RS07735	COG2076	Multidrug Resistance protein
F6X58_RS07750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F6X58_RS07760	COG1077	Cell shape determining protein MreB Mrl
F6X58_RS07765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F6X58_RS07770	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F6X58_RS07775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F6X58_RS07780	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F6X58_RS07785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F6X58_RS07790	COG1942	4-Oxalocrotonate Tautomerase
F6X58_RS07800	COG0330	HflC and HflK could
F6X58_RS07815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F6X58_RS07820	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F6X58_RS07825	COG0492	ferredoxin-NADP+ reductase activity
F6X58_RS07830	COG3118	belongs to the thioredoxin family
F6X58_RS07835	COG0792	nuclease activity
F6X58_RS07840	COG0460	homoserine dehydrogenase
F6X58_RS07845	COG0436	Aminotransferase
F6X58_RS07865	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F6X58_RS07870	COG0254	rRNA binding
F6X58_RS07875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F6X58_RS07895	COG0602	queuosine metabolic process
F6X58_RS07900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F6X58_RS07920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F6X58_RS07930	COG1007	ATP synthesis coupled electron transport
F6X58_RS07935	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6X58_RS07940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F6X58_RS07950	COG0839	Belongs to the complex I subunit 6 family
F6X58_RS07960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F6X58_RS07985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6X58_RS07990	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6X58_RS07995	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F6X58_RS08000	COG4608	Belongs to the ABC transporter superfamily
F6X58_RS08005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F6X58_RS08010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F6X58_RS08105	COG0861	Integral membrane protein TerC family
F6X58_RS08110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F6X58_RS08115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F6X58_RS08115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F6X58_RS08130	COG0606	chelatase, subunit chli
F6X58_RS08135	COG0242	peptide deformylase activity
F6X58_RS08145	COG0740	serine-type endopeptidase activity
F6X58_RS08150	COG0544	peptidyl-prolyl cis-trans isomerase activity
F6X58_RS08155	COG0302	gtp cyclohydrolase
F6X58_RS08160	COG1157	protein secretion by the type III secretion system
F6X58_RS08190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F6X58_RS08195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F6X58_RS08205	COG2860	membrane
F6X58_RS08215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F6X58_RS08225	COG0328	RNA-DNA hybrid ribonuclease activity
F6X58_RS08235	COG0358	DNA primase activity
F6X58_RS08245	COG0840	transmembrane signaling receptor activity
F6X58_RS08250	COG4953	penicillin-binding protein 1C
F6X58_RS08255	COG2373	Large extracellular alpha-helical protein
F6X58_RS08270	COG0668	transmembrane transport
F6X58_RS08275	COG0288	reversible hydration of carbon dioxide
F6X58_RS08280	COG0670	Belongs to the BI1 family
F6X58_RS08285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F6X58_RS08290	COG0233	cytoplasmic translational termination
F6X58_RS08295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F6X58_RS08305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F6X58_RS08320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F6X58_RS08340	COG1217	gtp-binding protein TYPA
F6X58_RS08360	COG1749	Flagellar hook protein flgE
F6X58_RS08390	COG2184	nucleotidyltransferase activity
F6X58_RS08395	COG3842	ATPase activity
F6X58_RS08405	COG1840	ABC-type Fe3 transport system, periplasmic component
F6X58_RS08420	COG4615	Cyclic peptide transporter
F6X58_RS08450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F6X58_RS08455	COG0575	Belongs to the CDS family
F6X58_RS08485	COG2056	Na+-H+ antiporter family
F6X58_RS08490	COG0129	dihydroxy-acid dehydratase activity
F6X58_RS08515	COG0840	transmembrane signaling receptor activity
F6X58_RS08525	COG1222	aaa ATPase
F6X58_RS08535	COG1666	GTP binding
F6X58_RS08540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F6X58_RS08545	COG0754	glutathionylspermidine amidase activity
F6X58_RS08555	COG1280	lysine exporter protein (LysE YggA)
F6X58_RS08560	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F6X58_RS08595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F6X58_RS08600	COG1981	membrane
F6X58_RS08610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F6X58_RS08620	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F6X58_RS08620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F6X58_RS08645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F6X58_RS08660	COG3504	Conjugal transfer protein
F6X58_RS08665	COG3701	Conjugal transfer protein
F6X58_RS08690	COG3451	type IV secretory pathway VirB4
F6X58_RS08695	COG5268	conjugation
F6X58_RS08705	COG4962	Type ii secretion system protein e
F6X58_RS08760	COG1192	Involved in chromosome partitioning
F6X58_RS08800	COG0629	single-stranded DNA binding