locus-tag	class	description
CleRt_RS00010	COG0592	DNA-directed DNA polymerase activity
CleRt_RS00040	COG0742	ribosomal rna small subunit methyltransferase
CleRt_RS00055	COG0552	protein localization to endoplasmic reticulum
CleRt_RS00085	COG0751	glycine-tRNA ligase activity
CleRt_RS00090	COG0589	response to stress
CleRt_RS00125	COG1192	Involved in chromosome partitioning
CleRt_RS00130	COG1475	DNA binding
CleRt_RS00250	COG0339	signal peptide processing
CleRt_RS00300	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CleRt_RS00325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CleRt_RS00330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CleRt_RS00345	COG0813	purine-nucleoside phosphorylase activity
CleRt_RS00435	COG0189	ligase activity
CleRt_RS00445	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CleRt_RS00450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CleRt_RS00475	COG1509	lysine 2,3-aminomutase activity
CleRt_RS00565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CleRt_RS00605	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CleRt_RS00615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CleRt_RS00670	COG1607	acyl-coa hydrolase
CleRt_RS00675	COG0531	amino acid
CleRt_RS00690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CleRt_RS00690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CleRt_RS00730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CleRt_RS00740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CleRt_RS00745	COG0126	phosphoglycerate kinase activity
CleRt_RS00750	COG0469	pyruvate kinase activity
CleRt_RS00755	COG0191	fructose-bisphosphate aldolase activity
CleRt_RS00835	COG1116	anion transmembrane transporter activity
CleRt_RS00840	COG2945	thiolester hydrolase activity
CleRt_RS00845	COG1918	ferrous iron import across plasma membrane
CleRt_RS00850	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CleRt_RS00890	COG0625	glutathione transferase activity
CleRt_RS00895	COG2969	positive regulation of protein catabolic process
CleRt_RS00900	COG1994	Peptidase M50
CleRt_RS00905	COG2823	Periplasmic or secreted lipoprotein
CleRt_RS00920	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CleRt_RS00925	COG0776	regulation of translation
CleRt_RS00940	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CleRt_RS00990	COG0439	Biotin carboxylase
CleRt_RS00995	COG0511	ligase activity, forming carbon-carbon bonds
CleRt_RS01020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CleRt_RS01035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CleRt_RS01065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CleRt_RS01070	COG0450	alkyl hydroperoxide reductase
CleRt_RS01075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CleRt_RS01095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CleRt_RS01100	COG2878	Part of a membrane complex involved in electron transport
CleRt_RS01110	COG0489	protein tyrosine kinase activity
CleRt_RS01135	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CleRt_RS01170	COG0859	PFAM glycosyl transferase family 9
CleRt_RS01175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CleRt_RS01180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CleRt_RS01215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CleRt_RS01370	COG0156	8-amino-7-oxononanoate synthase activity
CleRt_RS01375	COG0156	8-amino-7-oxononanoate synthase activity
CleRt_RS01410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CleRt_RS01415	COG0358	DNA primase activity
CleRt_RS01430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CleRt_RS01450	COG1376	ErfK ybiS ycfS ynhG family protein
CleRt_RS01510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CleRt_RS01545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CleRt_RS01545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CleRt_RS01585	COG0793	Belongs to the peptidase S41A family
CleRt_RS01615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CleRt_RS01650	COG1054	Belongs to the UPF0176 family
CleRt_RS01720	COG0215	cysteine-tRNA ligase activity
CleRt_RS01795	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CleRt_RS01800	COG1077	Cell shape determining protein MreB Mrl
CleRt_RS01805	COG1792	Involved in formation and maintenance of cell shape
CleRt_RS01825	COG0312	modulator of DNA gyrase
CleRt_RS01890	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CleRt_RS01935	COG1007	ATP synthesis coupled electron transport
CleRt_RS01950	COG0195	Participates in both transcription termination and antitermination
CleRt_RS01950	COG2251	uridine kinase activity
CleRt_RS02025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CleRt_RS02030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CleRt_RS02045	COG0372	Belongs to the citrate synthase family
CleRt_RS02050	COG2009	succinate dehydrogenase
CleRt_RS02055	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CleRt_RS02060	COG1053	succinate dehydrogenase
CleRt_RS02065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CleRt_RS02070	COG0567	Dehydrogenase, E1 component
CleRt_RS02080	COG0045	succinate-CoA ligase (ADP-forming) activity
CleRt_RS02085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CleRt_RS02120	COG0528	UMP kinase activity
CleRt_RS02130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CleRt_RS02135	COG0575	Belongs to the CDS family
CleRt_RS02140	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CleRt_RS02190	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CleRt_RS02210	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CleRt_RS02225	COG0673	inositol 2-dehydrogenase activity
CleRt_RS02245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CleRt_RS02280	COG4999	Histidine kinase
CleRt_RS02280	COG3850	Histidine kinase
CleRt_RS02280	COG3437	response regulator, receiver
CleRt_RS02280	COG2205	protein histidine kinase activity
CleRt_RS02315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CleRt_RS02315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CleRt_RS02320	COG0307	riboflavin synthase, alpha
CleRt_RS02345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CleRt_RS02355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CleRt_RS02395	COG0662	Cupin 2, conserved barrel domain protein
CleRt_RS02395	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CleRt_RS02400	COG0438	transferase activity, transferring glycosyl groups
CleRt_RS02405	COG0367	asparagine synthase
CleRt_RS02455	COG0165	Argininosuccinate lyase
CleRt_RS02475	COG2070	2-Nitropropane dioxygenase
CleRt_RS02485	COG2070	2-Nitropropane dioxygenase
CleRt_RS02525	COG0019	diaminopimelate decarboxylase activity
CleRt_RS02535	COG0010	Belongs to the arginase family
CleRt_RS02545	COG0028	Belongs to the TPP enzyme family
CleRt_RS02595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CleRt_RS02600	COG0312	modulator of DNA gyrase
CleRt_RS02610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CleRt_RS02615	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CleRt_RS02620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CleRt_RS02625	COG1137	ATPase activity
CleRt_RS02640	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CleRt_RS02650	COG1127	ABC transporter
CleRt_RS02655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CleRt_RS02660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CleRt_RS02665	COG2854	intermembrane phospholipid transfer
CleRt_RS02700	COG0564	pseudouridine synthase activity
CleRt_RS02735	COG0318	PFAM AMP-dependent synthetase and ligase
CleRt_RS02740	COG0318	PFAM AMP-dependent synthetase and ligase
CleRt_RS02805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CleRt_RS02810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CleRt_RS02830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CleRt_RS02830	COG0072	phenylalanine-tRNA ligase activity
CleRt_RS02880	COG0475	glutathione-regulated potassium exporter activity
CleRt_RS02925	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CleRt_RS02945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CleRt_RS02960	COG0673	inositol 2-dehydrogenase activity
CleRt_RS02980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CleRt_RS03015	COG2205	protein histidine kinase activity
CleRt_RS03015	COG3437	response regulator, receiver
CleRt_RS03015	COG3850	Histidine kinase
CleRt_RS03015	COG4999	Histidine kinase
CleRt_RS03050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CleRt_RS03050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CleRt_RS03055	COG0307	riboflavin synthase, alpha
CleRt_RS03080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CleRt_RS03090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CleRt_RS03130	COG0662	Cupin 2, conserved barrel domain protein
CleRt_RS03130	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CleRt_RS03135	COG0438	transferase activity, transferring glycosyl groups
CleRt_RS03140	COG0367	asparagine synthase
CleRt_RS03190	COG0165	Argininosuccinate lyase
CleRt_RS03210	COG2070	2-Nitropropane dioxygenase
CleRt_RS03220	COG2070	2-Nitropropane dioxygenase
CleRt_RS03260	COG0019	diaminopimelate decarboxylase activity
CleRt_RS03270	COG0010	Belongs to the arginase family
CleRt_RS03280	COG0028	Belongs to the TPP enzyme family
CleRt_RS03330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CleRt_RS03335	COG0312	modulator of DNA gyrase
CleRt_RS03345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CleRt_RS03350	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CleRt_RS03355	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CleRt_RS03360	COG1137	ATPase activity
CleRt_RS03375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CleRt_RS03385	COG1127	ABC transporter
CleRt_RS03390	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CleRt_RS03395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CleRt_RS03400	COG2854	intermembrane phospholipid transfer
CleRt_RS03435	COG0564	pseudouridine synthase activity
CleRt_RS03470	COG0318	PFAM AMP-dependent synthetase and ligase
CleRt_RS03475	COG0318	PFAM AMP-dependent synthetase and ligase
CleRt_RS03540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CleRt_RS03545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CleRt_RS03565	COG0072	phenylalanine-tRNA ligase activity
CleRt_RS03565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CleRt_RS03615	COG0475	glutathione-regulated potassium exporter activity
CleRt_RS03705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CleRt_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
CleRt_RS03715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CleRt_RS03720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CleRt_RS03730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CleRt_RS03740	COG0084	hydrolase, TatD family'
CleRt_RS03760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CleRt_RS03810	COG0436	Aminotransferase
CleRt_RS03825	COG0402	S-adenosylhomocysteine deaminase activity
CleRt_RS03840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CleRt_RS03845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CleRt_RS03850	COG0539	negative regulation of cytoplasmic translation
CleRt_RS03860	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CleRt_RS03890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CleRt_RS03915	COG1196	nuclear chromosome segregation
CleRt_RS03955	COG1704	LemA family
CleRt_RS03970	COG2951	lytic endotransglycosylase activity
CleRt_RS03975	COG0772	Belongs to the SEDS family
CleRt_RS03980	COG0768	penicillin binding
CleRt_RS04010	COG0495	leucyl-tRNA aminoacylation
CleRt_RS04020	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CleRt_RS04045	COG0531	amino acid
CleRt_RS04060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CleRt_RS04065	COG5007	Belongs to the BolA IbaG family
CleRt_RS04070	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CleRt_RS04080	COG0543	2 iron, 2 sulfur cluster binding
CleRt_RS04080	COG0493	'glutamate synthase
CleRt_RS04130	COG0494	nUDIX hydrolase
CleRt_RS04145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CleRt_RS04155	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CleRt_RS04165	COG1074	ATP-dependent DNA helicase activity
CleRt_RS04245	COG0538	isocitrate dehydrogenase activity
CleRt_RS04260	COG0492	ferredoxin-NADP+ reductase activity
CleRt_RS04265	COG1674	ftsk spoiiie
CleRt_RS04280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CleRt_RS04300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CleRt_RS04350	COG2223	nitrite transmembrane transporter activity
CleRt_RS04360	COG0259	pyridoxamine-phosphate oxidase activity
CleRt_RS04365	COG2094	Belongs to the DNA glycosylase MPG family
CleRt_RS04375	COG0842	Transport permease protein
CleRt_RS04380	COG1131	(ABC) transporter
CleRt_RS04395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CleRt_RS04410	COG1194	a g-specific adenine glycosylase
CleRt_RS04500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CleRt_RS04505	COG0668	transmembrane transport
CleRt_RS04550	COG0860	N-Acetylmuramoyl-L-alanine amidase
CleRt_RS04555	COG0802	atpase or kinase
CleRt_RS04560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CleRt_RS04560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CleRt_RS04565	COG0557	exoribonuclease II activity
CleRt_RS04585	COG0114	fumarate hydratase activity
CleRt_RS04590	COG0681	Belongs to the peptidase S26 family
CleRt_RS04625	COG0686	Belongs to the AlaDH PNT family
CleRt_RS04670	COG1104	cysteine desulfurase activity
CleRt_RS04675	COG1297	OPT oligopeptide transporter protein
CleRt_RS04685	COG0483	inositol monophosphate 1-phosphatase activity
CleRt_RS04705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CleRt_RS04710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CleRt_RS04715	COG1862	Preprotein translocase
CleRt_RS04760	COG0071	Belongs to the small heat shock protein (HSP20) family
CleRt_RS04855	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CleRt_RS04895	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CleRt_RS04900	COG1845	cytochrome c oxidase, subunit III
CleRt_RS04905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CleRt_RS04910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CleRt_RS04970	COG1960	acyl-CoA dehydrogenase activity
CleRt_RS04980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CleRt_RS04985	COG1024	Enoyl-CoA hydratase
CleRt_RS04995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CleRt_RS05015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CleRt_RS05035	COG0242	peptide deformylase activity
CleRt_RS05050	COG1136	(ABC) transporter
CleRt_RS05055	COG4591	ABC-type transport system involved in lipoprotein release permease component
CleRt_RS05065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CleRt_RS05070	COG2226	methyltransferase
CleRt_RS05075	COG2267	carboxylic ester hydrolase activity
CleRt_RS05080	COG0156	8-amino-7-oxononanoate synthase activity
CleRt_RS05115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CleRt_RS05150	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CleRt_RS05155	COG0527	aspartate kinase activity
CleRt_RS05165	COG2137	regulation of response to DNA damage stimulus
CleRt_RS05170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CleRt_RS05190	COG3104	oligopeptide transport
CleRt_RS05210	COG1187	pseudouridine synthase activity
CleRt_RS05215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CleRt_RS05220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CleRt_RS05225	COG0009	L-threonylcarbamoyladenylate synthase
CleRt_RS05235	COG2350	Protein conserved in bacteria
CleRt_RS05285	COG0285	dihydrofolate synthase activity
CleRt_RS05335	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CleRt_RS05355	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CleRt_RS05365	COG0305	Participates in initiation and elongation during chromosome replication
CleRt_RS05400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CleRt_RS05400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CleRt_RS05410	COG1132	(ABC) transporter
CleRt_RS05435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CleRt_RS05475	COG0367	asparagine synthase
CleRt_RS05510	COG0367	asparagine synthase
CleRt_RS05555	COG0795	lipopolysaccharide-transporting ATPase activity
CleRt_RS05560	COG0525	valine-tRNA ligase activity
CleRt_RS05565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CleRt_RS05570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CleRt_RS05575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CleRt_RS05610	COG1566	PFAM secretion protein HlyD family protein
CleRt_RS05615	COG2814	Major facilitator Superfamily
CleRt_RS05620	COG0537	adenosine 5'-monophosphoramidase activity
CleRt_RS05795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CleRt_RS05815	COG0316	Belongs to the HesB IscA family
CleRt_RS05825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CleRt_RS05830	COG0719	Fe-S assembly protein
CleRt_RS05835	COG0396	ATPase activity
CleRt_RS05840	COG0719	Fe-S assembly protein
CleRt_RS05850	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CleRt_RS05870	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CleRt_RS05880	COG1214	PFAM Peptidase M22, glycoprotease
CleRt_RS05910	COG2976	Protein conserved in bacteria
CleRt_RS05945	COG0142	geranyltranstransferase activity
CleRt_RS05960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CleRt_RS05965	COG1686	Belongs to the peptidase S11 family
CleRt_RS05990	COG0586	Pfam SNARE associated Golgi protein
CleRt_RS06000	COG1607	acyl-coa hydrolase
CleRt_RS06015	COG0205	6-phosphofructokinase activity
CleRt_RS06030	COG0800	Aldolase
CleRt_RS06045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CleRt_RS06055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CleRt_RS06095	COG0735	belongs to the Fur family
CleRt_RS06175	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CleRt_RS06200	COG2226	methyltransferase
CleRt_RS06205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CleRt_RS06210	COG0508	dehydrogenase complex catalyzes the overall conversion of
CleRt_RS06275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CleRt_RS06280	COG2271	Major facilitator Superfamily
CleRt_RS06285	COG0354	folic acid binding
CleRt_RS06295	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CleRt_RS06330	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CleRt_RS06370	COG0196	riboflavin kinase activity
CleRt_RS06375	COG0728	peptidoglycan biosynthetic process
CleRt_RS06400	COG0142	geranyltranstransferase activity
CleRt_RS06420	COG0477	Major facilitator Superfamily
CleRt_RS06450	COG0546	phosphoglycolate phosphatase activity
CleRt_RS06465	COG0308	aminopeptidase N
CleRt_RS06470	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CleRt_RS06570	COG2226	methyltransferase
CleRt_RS06570	COG1073	alpha beta
CleRt_RS06580	COG0741	lytic transglycosylase activity
CleRt_RS06580	COG1388	LysM domain
CleRt_RS06595	COG0326	Molecular chaperone. Has ATPase activity
CleRt_RS06605	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CleRt_RS06615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CleRt_RS06625	COG0194	GDP metabolic process
CleRt_RS06640	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CleRt_RS06645	COG0708	Exodeoxyribonuclease III
CleRt_RS06650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CleRt_RS06655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CleRt_RS06675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CleRt_RS06680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CleRt_RS06690	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CleRt_RS06695	COG0617	tRNA 3'-terminal CCA addition
CleRt_RS06725	COG2095	MarC family integral membrane protein
CleRt_RS06730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CleRt_RS06740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CleRt_RS06750	COG2814	Major facilitator Superfamily
CleRt_RS06755	COG0629	single-stranded DNA binding
CleRt_RS06820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CleRt_RS07000	COG2091	lysine biosynthetic process via aminoadipic acid
CleRt_RS07015	COG0670	Belongs to the BI1 family
CleRt_RS07110	COG1760	l-serine dehydratase
CleRt_RS07160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CleRt_RS07255	COG0237	dephospho-CoA kinase activity
CleRt_RS07270	COG0653	protein targeting
CleRt_RS07290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CleRt_RS07305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CleRt_RS07325	COG0772	Belongs to the SEDS family
CleRt_RS07340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CleRt_RS07345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CleRt_RS07355	COG3116	cell division
CleRt_RS07380	COG0156	8-amino-7-oxononanoate synthase activity
CleRt_RS07450	COG1183	phosphatidylcholine synthase activity
CleRt_RS07460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CleRt_RS07470	COG0542	response to heat
CleRt_RS07490	COG2885	chlorophyll binding
CleRt_RS07495	COG0823	Involved in the tonB-independent uptake of proteins
CleRt_RS07520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CleRt_RS07525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CleRt_RS07530	COG0006	proline dipeptidase activity
CleRt_RS07540	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CleRt_RS07545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CleRt_RS07570	COG1519	Transferase
CleRt_RS07665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CleRt_RS07675	COG2890	protein-(glutamine-N5) methyltransferase activity
CleRt_RS07690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CleRt_RS07695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CleRt_RS07720	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CleRt_RS07725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CleRt_RS07730	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CleRt_RS07745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CleRt_RS07745	COG0616	signal peptide processing
CleRt_RS07770	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CleRt_RS07790	COG0009	L-threonylcarbamoyladenylate synthase
CleRt_RS07795	COG0859	PFAM glycosyl transferase family 9
CleRt_RS07835	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CleRt_RS07870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CleRt_RS07960	COG0180	Tryptophanyl-tRNA synthetase
CleRt_RS07965	COG0210	DNA helicase
CleRt_RS08030	COG0204	Acyl-transferase
CleRt_RS08045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CleRt_RS08050	COG2959	enzyme of heme biosynthesis
CleRt_RS08070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CleRt_RS08095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CleRt_RS08395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CleRt_RS08520	COG0606	chelatase, subunit chli
CleRt_RS08545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CleRt_RS08550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CleRt_RS08555	COG0357	Ribosomal RNA small subunit methyltransferase G
CleRt_RS08580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CleRt_RS08750	COG3321	synthase
CleRt_RS08750	COG1028	Short-chain dehydrogenase reductase Sdr
CleRt_RS08750	COG0604	alcohol dehydrogenase
CleRt_RS08825	COG1809	phosphosulfolactate synthase activity
CleRt_RS08905	COG1809	phosphosulfolactate synthase activity
CleRt_RS09035	COG2076	Multidrug Resistance protein
CleRt_RS09050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CleRt_RS09075	COG0343	queuine tRNA-ribosyltransferase activity
CleRt_RS09125	COG0301	tRNA thio-modification
CleRt_RS09265	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CleRt_RS09280	COG4264	IucA IucC family
CleRt_RS09340	COG2003	Belongs to the UPF0758 family
CleRt_RS09370	COG3321	synthase
CleRt_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
CleRt_RS09370	COG0318	PFAM AMP-dependent synthetase and ligase
CleRt_RS09370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CleRt_RS09370	COG0300	oxidoreductase activity
CleRt_RS09440	COG3161	chorismate lyase activity
CleRt_RS09445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CleRt_RS09515	COG1132	(ABC) transporter
CleRt_RS09520	COG1132	(ABC) transporter
CleRt_RS09525	COG5001	Diguanylate cyclase