locus-tag	class	description
P856_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
P856_RS00010	COG0424	maF-like protein
P856_RS00015	COG0237	dephospho-CoA kinase activity
P856_RS00020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
P856_RS00025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
P856_RS00035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
P856_RS00035	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
P856_RS00040	COG0509	glycine decarboxylation via glycine cleavage system
P856_RS00045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
P856_RS00050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
P856_RS00055	COG0328	RNA-DNA hybrid ribonuclease activity
P856_RS00060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
P856_RS00065	COG2835	tetraacyldisaccharide 4'-kinase activity
P856_RS00075	COG0180	Tryptophanyl-tRNA synthetase
P856_RS00080	COG0330	HflC and HflK could
P856_RS00090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
P856_RS00110	COG0012	GTP binding
P856_RS00115	COG0193	aminoacyl-tRNA hydrolase activity
P856_RS00120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
P856_RS00125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
P856_RS00135	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
P856_RS00140	COG0564	pseudouridine synthase activity
P856_RS00150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
P856_RS00155	COG1862	Preprotein translocase
P856_RS00160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P856_RS00170	COG3737	Protein of unknown function (DUF498/DUF598)
P856_RS00175	COG0717	Belongs to the dCTP deaminase family
P856_RS00190	COG0612	Peptidase, M16
P856_RS00195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
P856_RS00200	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
P856_RS00205	COG1185	polyribonucleotide nucleotidyltransferase activity
P856_RS00215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
P856_RS00240	COG0779	Required for maturation of 30S ribosomal subunits
P856_RS00245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
P856_RS00250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
P856_RS00255	COG1253	flavin adenine dinucleotide binding
P856_RS00260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
P856_RS00265	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
P856_RS00285	COG0590	tRNA wobble adenosine to inosine editing
P856_RS00310	COG0670	Belongs to the BI1 family
P856_RS00315	COG0215	cysteine-tRNA ligase activity
P856_RS00320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P856_RS00330	COG0210	DNA helicase
P856_RS00335	COG0166	Belongs to the GPI family
P856_RS00340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
P856_RS00350	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
P856_RS00360	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P856_RS00365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
P856_RS00400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P856_RS00405	COG0527	aspartate kinase activity
P856_RS00410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
P856_RS00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
P856_RS00440	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
P856_RS00445	COG0752	glycyl-tRNA synthetase alpha subunit
P856_RS00450	COG0751	glycine-tRNA ligase activity
P856_RS00455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
P856_RS00455	COG0574	Belongs to the PEP-utilizing enzyme family
P856_RS00460	COG0598	Magnesium transport protein CorA
P856_RS00470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
P856_RS00475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
P856_RS00480	COG1104	cysteine desulfurase activity
P856_RS00485	COG2945	thiolester hydrolase activity
P856_RS00505	COG0438	transferase activity, transferring glycosyl groups
P856_RS00505	COG1216	Glycosyl transferase, family 2
P856_RS00515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
P856_RS00525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
P856_RS00545	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
P856_RS00560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
P856_RS00565	COG0629	single-stranded DNA binding
P856_RS00585	COG2086	electron transfer activity
P856_RS00595	COG0203	ribosomal protein L17
P856_RS00600	COG0202	RNA polymerase activity
P856_RS00605	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
P856_RS00610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
P856_RS00615	COG0563	adenylate kinase activity
P856_RS00620	COG0201	protein transport
P856_RS00625	COG0200	Binds to the 23S rRNA
P856_RS00630	COG1841	ribosomal large subunit assembly
P856_RS00635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
P856_RS00640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
P856_RS00650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
P856_RS00655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
P856_RS00660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
P856_RS00665	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
P856_RS00670	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
P856_RS00680	COG0255	Belongs to the universal ribosomal protein uL29 family
P856_RS00685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
P856_RS00690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
P856_RS00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
P856_RS00700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
P856_RS00735	COG0049	tRNA binding
P856_RS00740	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
P856_RS00745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
P856_RS00750	COG0085	RNA polymerase activity
P856_RS00755	COG0222	ribosome binding
P856_RS00760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
P856_RS00770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
P856_RS00790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
P856_RS00805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
P856_RS00810	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
P856_RS00840	COG0678	peroxiredoxin activity
P856_RS00845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
P856_RS00850	COG0505	Belongs to the CarA family
P856_RS00855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
P856_RS00860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P856_RS00865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
P856_RS00870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
P856_RS00875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
P856_RS00880	COG0356	it plays a direct role in the translocation of protons across the membrane
P856_RS00895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
P856_RS00925	COG0142	geranyltranstransferase activity
P856_RS00930	COG0747	negative chemotaxis
P856_RS00935	COG0601	transmembrane transport
P856_RS00940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
P856_RS00945	COG4172	Belongs to the ABC transporter superfamily
P856_RS00955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
P856_RS00960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
P856_RS00965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
P856_RS00970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
P856_RS00975	COG0424	maF-like protein
P856_RS00990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
P856_RS01000	COG1573	uracil-dna glycosylase
P856_RS01005	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
P856_RS01010	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
P856_RS01015	COG1999	signal sequence binding
P856_RS01035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
P856_RS01045	COG0359	binds to the 23S rRNA
P856_RS01055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
P856_RS01065	COG0242	peptide deformylase activity
P856_RS01070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
P856_RS01075	COG0101	tRNA pseudouridine synthase activity
P856_RS01080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
P856_RS01085	COG0124	histidyl-tRNA synthetase
P856_RS01095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
P856_RS01100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
P856_RS01105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
P856_RS01110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
P856_RS01115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P856_RS01120	COG0154	amidase activity
P856_RS01125	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P856_RS01135	COG2226	methyltransferase
P856_RS01140	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
P856_RS01150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
P856_RS01170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
P856_RS01175	COG0228	four-way junction DNA binding
P856_RS01185	COG0254	rRNA binding
P856_RS01190	COG1160	GTP binding
P856_RS01195	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P856_RS01205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
P856_RS01210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
P856_RS01220	COG0525	valine-tRNA ligase activity
P856_RS01230	COG3425	synthase
P856_RS01245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
P856_RS01250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P856_RS01255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
P856_RS01270	COG0071	Belongs to the small heat shock protein (HSP20) family
P856_RS01285	COG0735	belongs to the Fur family
P856_RS01295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
P856_RS01295	COG2070	2-Nitropropane dioxygenase
P856_RS01305	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
P856_RS01320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
P856_RS01325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
P856_RS01330	COG0552	protein localization to endoplasmic reticulum
P856_RS01340	COG1530	ribonuclease E activity
P856_RS01345	COG0436	Aminotransferase
P856_RS01355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
P856_RS01355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
P856_RS01385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
P856_RS01390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
P856_RS01405	COG4536	flavin adenine dinucleotide binding
P856_RS01410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
P856_RS01415	COG1692	metallophosphoesterase
P856_RS01420	COG0217	transcriptional regulatory protein
P856_RS01425	COG0824	Thioesterase
P856_RS01430	COG2885	chlorophyll binding
P856_RS01440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P856_RS01445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
P856_RS01450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P856_RS01455	COG0351	phosphomethylpyrimidine kinase
P856_RS01455	COG0352	thiamine-phosphate diphosphorylase activity
P856_RS01460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
P856_RS01465	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
P856_RS01470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
P856_RS01480	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
P856_RS01485	COG1138	Cytochrome C-type biogenesis protein
P856_RS01495	COG3088	subunit of a heme lyase
P856_RS01505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
P856_RS01540	COG0259	pyridoxamine-phosphate oxidase activity
P856_RS01545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
P856_RS01550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
P856_RS01555	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
P856_RS01570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
P856_RS01575	COG4133	protoheme IX ABC transporter activity
P856_RS01580	COG0167	dihydroorotate dehydrogenase activity
P856_RS01590	COG0285	dihydrofolate synthase activity
P856_RS01595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
P856_RS01610	COG1573	uracil-dna glycosylase
P856_RS01615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
P856_RS01620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
P856_RS01630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
P856_RS01635	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
P856_RS01640	COG1007	ATP synthesis coupled electron transport
P856_RS01665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P856_RS01670	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
P856_RS01675	COG1034	ATP synthesis coupled electron transport
P856_RS01680	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
P856_RS01690	COG0649	NAD binding
P856_RS01695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P856_RS01700	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P856_RS01705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P856_RS01730	COG0740	serine-type endopeptidase activity
P856_RS01735	COG0544	peptidyl-prolyl cis-trans isomerase activity
P856_RS01750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
P856_RS01770	COG2010	Cytochrome c
P856_RS01785	COG0149	triose-phosphate isomerase activity
P856_RS01790	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
P856_RS01800	COG2877	3-deoxy-8-phosphooctulonate synthase activity
P856_RS01805	COG0148	phosphopyruvate hydratase activity
P856_RS01815	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
P856_RS01820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P856_RS01825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
P856_RS01850	COG1028	Short-chain dehydrogenase reductase Sdr
P856_RS01860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
P856_RS01865	COG3321	synthase
P856_RS01875	COG2818	Glycosylase
P856_RS01895	COG0706	membrane insertase activity
P856_RS01900	COG0594	ribonuclease P activity
P856_RS01905	COG0137	argininosuccinate synthase activity
P856_RS01910	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
P856_RS01920	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
P856_RS01925	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
P856_RS01935	COG1051	belongs to the nudix hydrolase family
P856_RS01950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
P856_RS01955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
P856_RS01970	COG0542	response to heat
P856_RS01975	COG2890	protein-(glutamine-N5) methyltransferase activity
P856_RS01985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
P856_RS01990	COG0799	negative regulation of ribosome biogenesis
P856_RS01995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
P856_RS02000	COG0305	Participates in initiation and elongation during chromosome replication
P856_RS02005	COG0483	inositol monophosphate 1-phosphatase activity
P856_RS02010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
P856_RS02015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
P856_RS02020	COG0022	dehydrogenase e1 component
P856_RS02020	COG0508	dehydrogenase complex catalyzes the overall conversion of
P856_RS02025	COG0508	dehydrogenase complex catalyzes the overall conversion of
P856_RS02030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P856_RS02035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
P856_RS02040	COG2867	negative regulation of translational initiation
P856_RS02060	COG2902	Dehydrogenase
P856_RS02065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
P856_RS02080	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
P856_RS02085	COG2009	succinate dehydrogenase
P856_RS02095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
P856_RS02100	COG4221	oxidoreductase activity
P856_RS02115	COG1840	ABC-type Fe3 transport system, periplasmic component
P856_RS02120	COG2358	TRAP transporter, solute receptor (TAXI family
P856_RS02145	COG0489	protein tyrosine kinase activity
P856_RS02150	COG0330	HflC and HflK could
P856_RS02155	COG0330	HflC and HflK could
P856_RS02160	COG1218	3'(2'),5'-bisphosphate nucleotidase
P856_RS02165	COG0400	carboxylic ester hydrolase activity
P856_RS02170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P856_RS02175	COG2226	methyltransferase
P856_RS02180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
P856_RS02185	COG0268	Binds directly to 16S ribosomal RNA
P856_RS02190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
P856_RS02215	COG0187	DNA topoisomerase II activity
P856_RS02265	COG0463	Glycosyl transferase, family 2
P856_RS02270	COG0438	transferase activity, transferring glycosyl groups
P856_RS02275	COG0052	Belongs to the universal ribosomal protein uS2 family
P856_RS02280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
P856_RS02285	COG0528	UMP kinase activity
P856_RS02290	COG0233	cytoplasmic translational termination
P856_RS02295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
P856_RS02305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
P856_RS02310	COG0750	zinc metalloprotease
P856_RS02315	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P856_RS02330	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P856_RS02335	COG3494	Protein of unknown function (DUF1009)
P856_RS02340	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
P856_RS02345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P856_RS02350	COG0372	Belongs to the citrate synthase family
P856_RS02355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P856_RS02370	COG0698	ribose 5-phosphate isomerase
P856_RS02380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P856_RS02380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P856_RS02390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
P856_RS02390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
P856_RS02395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
P856_RS02400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
P856_RS02405	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
P856_RS02410	COG2814	Major facilitator Superfamily
P856_RS02425	COG0416	fatty acid biosynthetic process
P856_RS02430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
P856_RS02435	COG0776	regulation of translation
P856_RS02475	COG0271	Belongs to the BolA IbaG family
P856_RS02490	COG0538	isocitrate dehydrogenase activity
P856_RS02510	COG1653	transport
P856_RS02540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
P856_RS02545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
P856_RS02550	COG0795	lipopolysaccharide-transporting ATPase activity
P856_RS02565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
P856_RS02570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
P856_RS02575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
P856_RS02580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
P856_RS02585	COG0312	modulator of DNA gyrase
P856_RS02595	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
P856_RS02600	COG1686	Belongs to the peptidase S11 family
P856_RS02610	COG0442	prolyl-tRNA aminoacylation
P856_RS02630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
P856_RS02640	COG2171	N-acyltransferase activity
P856_RS02645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
P856_RS02650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
P856_RS02675	COG0181	hydroxymethylbilane synthase activity
P856_RS02685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
P856_RS02690	COG0617	tRNA 3'-terminal CCA addition
P856_RS02695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
P856_RS02700	COG0483	inositol monophosphate 1-phosphatase activity
P856_RS02705	COG0756	dUTP diphosphatase activity
P856_RS02710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
P856_RS02715	COG0482	sulfurtransferase activity
P856_RS02725	COG1132	(ABC) transporter
P856_RS02735	COG1120	ATPase activity
P856_RS02740	COG0114	fumarate hydratase activity
P856_RS02750	COG0805	protein transport
P856_RS02760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P856_RS02765	COG3842	ATPase activity
P856_RS02825	COG0564	pseudouridine synthase activity
P856_RS02835	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
P856_RS02840	COG1278	Cold shock
P856_RS02845	COG0513	Belongs to the DEAD box helicase family
P856_RS02855	COG4139	cobalamin transport
P856_RS02865	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
P856_RS02870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
P856_RS02875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
P856_RS02890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
P856_RS02895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
P856_RS02905	COG0519	Catalyzes the synthesis of GMP from XMP
P856_RS02905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
P856_RS02920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
P856_RS02925	COG1127	ABC transporter
P856_RS02935	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
P856_RS02940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
P856_RS02950	COG0573	inorganic phosphate transmembrane transporter activity
P856_RS02960	COG0803	Belongs to the bacterial solute-binding protein 9 family
P856_RS02970	COG1121	(ABC) transporter
P856_RS02975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P856_RS02980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P856_RS02985	COG2154	pterin-4-alpha-carbinolamine dehydratase
P856_RS02995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
P856_RS03015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
P856_RS03020	COG0142	geranyltranstransferase activity
P856_RS03025	COG1722	exodeoxyribonuclease VII activity
P856_RS03040	COG0218	Necessary for normal cell division and for the maintenance of normal septation
P856_RS03055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
P856_RS03060	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
P856_RS03065	COG0047	phosphoribosylformylglycinamidine synthase activity
P856_RS03070	COG0408	coproporphyrinogen oxidase activity
P856_RS03075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P856_RS03085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
P856_RS03090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
P856_RS03095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
P856_RS03120	COG0316	Belongs to the HesB IscA family
P856_RS03125	COG0288	reversible hydration of carbon dioxide
P856_RS03130	COG0284	orotidine-5'-phosphate decarboxylase activity
P856_RS03140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
P856_RS03145	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
P856_RS03155	COG2226	methyltransferase
P856_RS03170	COG0277	FAD linked oxidase domain protein
P856_RS03175	COG0009	L-threonylcarbamoyladenylate synthase
P856_RS03180	COG0511	ligase activity, forming carbon-carbon bonds
P856_RS03185	COG0439	Biotin carboxylase
P856_RS03225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
P856_RS03235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
P856_RS03245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
P856_RS03250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
P856_RS03260	COG1181	Belongs to the D-alanine--D-alanine ligase family
P856_RS03270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
P856_RS03275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
P856_RS03285	COG0596	Alpha beta hydrolase
P856_RS03290	COG0438	transferase activity, transferring glycosyl groups
P856_RS03295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
P856_RS03300	COG1086	Polysaccharide biosynthesis protein
P856_RS03325	COG0138	bifunctional purine biosynthesis protein purh
P856_RS03330	COG0291	Belongs to the bacterial ribosomal protein bL35 family
P856_RS03335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
P856_RS03340	COG2124	cytochrome p450
P856_RS03345	COG2124	cytochrome p450
P856_RS03355	COG0686	Belongs to the AlaDH PNT family
P856_RS03360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
P856_RS03365	COG0174	glutamine synthetase
P856_RS03375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
P856_RS03395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
P856_RS03415	COG0280	phosphate acetyltransferase
P856_RS03415	COG0281	malic enzyme
P856_RS03420	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
P856_RS03430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
P856_RS03435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
P856_RS03440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
P856_RS03450	COG0772	Belongs to the SEDS family
P856_RS03455	COG0768	penicillin binding
P856_RS03480	COG0492	ferredoxin-NADP+ reductase activity
P856_RS03485	COG0560	Phosphoserine phosphatase
P856_RS03485	COG3830	Belongs to the UPF0237 family
P856_RS03490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
P856_RS03510	COG1546	Belongs to the CinA family
P856_RS03510	COG1058	Belongs to the CinA family
P856_RS03515	COG1489	DNA binding
P856_RS03520	COG0024	Methionine aminopeptidase
P856_RS03525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
P856_RS03535	COG2151	metal-sulfur cluster biosynthetic enzyme
P856_RS03540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
P856_RS03545	COG0719	Fe-S assembly protein
P856_RS03550	COG0396	ATPase activity
P856_RS03555	COG0719	Fe-S assembly protein
P856_RS03565	COG2166	iron-sulfur cluster assembly
P856_RS03580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
P856_RS03590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
P856_RS03595	COG0436	Aminotransferase
P856_RS03600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
P856_RS03615	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
P856_RS03625	COG0333	Belongs to the bacterial ribosomal protein bL32 family
P856_RS03635	COG0354	folic acid binding
P856_RS03640	COG1178	ABC-type Fe3 transport system permease component
P856_RS03650	COG1321	iron dependent repressor
P856_RS03655	COG0569	domain protein
P856_RS03665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P856_RS03670	COG1968	undecaprenyl-diphosphatase activity
P856_RS03675	COG1663	tetraacyldisaccharide 4'-kinase activity
P856_RS03680	COG1519	Transferase
P856_RS03690	COG2957	Belongs to the agmatine deiminase family
P856_RS03700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
P856_RS03705	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
P856_RS03725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
P856_RS03725	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
P856_RS03730	COG2897	thiosulfate sulfurtransferase activity
P856_RS03735	COG5265	(ABC) transporter
P856_RS03740	COG0556	nucleotide-excision repair
P856_RS03750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
P856_RS03755	COG0539	negative regulation of cytoplasmic translation
P856_RS03760	COG0776	regulation of translation
P856_RS03765	COG1074	ATP-dependent DNA helicase activity
P856_RS03775	COG0802	atpase or kinase
P856_RS03790	COG0681	Belongs to the peptidase S26 family
P856_RS03795	COG0571	ribonuclease III activity
P856_RS03800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
P856_RS03805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
P856_RS03810	COG1971	Probably functions as a manganese efflux pump
P856_RS03815	COG0352	thiamine-phosphate diphosphorylase activity
P856_RS03820	COG1830	Aldolase
P856_RS03830	COG0492	ferredoxin-NADP+ reductase activity
P856_RS03835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
P856_RS03840	COG0540	Belongs to the ATCase OTCase family
P856_RS03850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
P856_RS03855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
P856_RS03860	COG0039	L-malate dehydrogenase activity
P856_RS03865	COG0045	succinate-CoA ligase (ADP-forming) activity
P856_RS03870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
P856_RS03880	COG0508	dehydrogenase complex catalyzes the overall conversion of
P856_RS03885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P856_RS03890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
P856_RS03900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
P856_RS03905	COG0084	hydrolase, TatD family'
P856_RS03910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P856_RS03920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
P856_RS03925	COG1028	Short-chain dehydrogenase reductase Sdr
P856_RS03925	COG3321	synthase
P856_RS03925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
P856_RS03925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P856_RS03925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
P856_RS03940	COG1024	Enoyl-CoA hydratase
P856_RS03945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
P856_RS03945	COG0300	oxidoreductase activity
P856_RS03945	COG3321	synthase
P856_RS03945	COG4221	oxidoreductase activity
P856_RS03950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
P856_RS03950	COG0300	oxidoreductase activity
P856_RS03950	COG3321	synthase
P856_RS03950	COG4221	oxidoreductase activity
P856_RS03965	COG3321	synthase
P856_RS03965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P856_RS03965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
P856_RS03965	COG1028	Short-chain dehydrogenase reductase Sdr
P856_RS03965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
P856_RS03970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P856_RS03975	COG1187	pseudouridine synthase activity
P856_RS03980	COG0196	riboflavin kinase activity
P856_RS03985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
P856_RS04010	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
P856_RS04025	COG1137	ATPase activity
P856_RS04040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
P856_RS04050	COG0445	tRNA wobble uridine modification
P856_RS04055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
P856_RS04070	COG3474	cytochrome
P856_RS04080	COG0126	phosphoglycerate kinase activity
P856_RS04085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P856_RS04085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P856_RS04090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
P856_RS04095	COG1981	membrane
P856_RS04100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
P856_RS04115	COG1024	Enoyl-CoA hydratase
P856_RS04120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
P856_RS04145	COG0037	tRNA processing
P856_RS04150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P856_RS04165	COG0358	DNA primase activity
P856_RS04170	COG0318	PFAM AMP-dependent synthetase and ligase
P856_RS04170	COG0300	oxidoreductase activity
P856_RS04170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
P856_RS04170	COG1028	Short-chain dehydrogenase reductase Sdr
P856_RS04170	COG3321	synthase