locus-tag	class	description
H0I88_RS00045	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
H0I88_RS00055	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
H0I88_RS00060	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
H0I88_RS00065	ENOG4105C85	amino acid
H0I88_RS00085	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
H0I88_RS00090	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
H0I88_RS00095	ENOG4105K63	Thioredoxin
H0I88_RS00115	ENOG4105C3M	thioredoxin reductase
H0I88_RS00120	ENOG4105C2M	dna polymerase I
H0I88_RS00125	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
H0I88_RS00165	ENOG4107QMH	DNA methylase
H0I88_RS00175	ENOG4105VFF	UPF0102 protein
H0I88_RS00180	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
H0I88_RS00185	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
H0I88_RS00190	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
H0I88_RS00200	ENOG4105VB6	UPF0109 protein
H0I88_RS00205	ENOG41080ND	30s ribosomal protein S16
H0I88_RS00215	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
H0I88_RS00220	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
H0I88_RS00225	ENOG4105C0B	DNA polymerase III (alpha subunit)
H0I88_RS00230	ENOG4108V0P	LemA family
H0I88_RS00245	ENOG4105CGK	Exodeoxyribonuclease III
H0I88_RS00255	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
H0I88_RS00265	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
H0I88_RS00270	ENOG4105CEV	competence damage-inducible protein
H0I88_RS00355	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
H0I88_RS00360	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
H0I88_RS00365	ENOG410624X	efflux transporter, rnd family, mfp subunit
H0I88_RS00375	ENOG4105VG0	50S ribosomal protein l34
H0I88_RS00380	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
H0I88_RS00385	ENOG41082YK	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
H0I88_RS00390	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
H0I88_RS00395	ENOG4108Z7S	Single-stranded nucleic acid binding R3H domain-containing protein
H0I88_RS00400	ENOG4105K4P	CoA-binding domain protein
H0I88_RS00405	ENOG4107VXZ	Hydrolase
H0I88_RS00410	ENOG4107QJE	Chromosome Partitioning Protein
H0I88_RS00415	ENOG4105FA0	parb-like partition protein
H0I88_RS00420	ENOG4107QUV	Domain protein
H0I88_RS00435	ENOG4105E9M	CRISPR-associated protein, Csn1 family
H0I88_RS00445	ENOG4105WKZ	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
H0I88_RS00465	ENOG4105CFP	Peptidase U32
H0I88_RS00495	ENOG4108J6I	peptidase, M16
H0I88_RS00500	ENOG4105D94	Major Facilitator Superfamily
H0I88_RS00505	ENOG4105D2H	Uronic isomerase
H0I88_RS00510	ENOG4105DMW	Dehydrogenase reductase
H0I88_RS00515	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
H0I88_RS00525	ENOG4108UHU	Aldolase
H0I88_RS00570	ENOG4108VZM	50s ribosomal protein L10
H0I88_RS00575	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
H0I88_RS00580	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
H0I88_RS00585	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
H0I88_RS00590	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
H0I88_RS00595	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
H0I88_RS00600	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
H0I88_RS00605	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
H0I88_RS00610	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
H0I88_RS00615	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
H0I88_RS00620	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
H0I88_RS00625	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
H0I88_RS00630	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H0I88_RS00635	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
H0I88_RS00640	ENOG4107XJ9	50S ribosomal protein L22
H0I88_RS00645	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
H0I88_RS00650	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
H0I88_RS00655	ENOG41082SA	50s ribosomal protein l29
H0I88_RS00660	ENOG41084D8	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
H0I88_RS00665	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
H0I88_RS00670	ENOG41080DU	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
H0I88_RS00675	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H0I88_RS00680	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
H0I88_RS00685	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
H0I88_RS00690	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
H0I88_RS00695	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
H0I88_RS00700	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
H0I88_RS00705	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
H0I88_RS00710	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
H0I88_RS00715	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
H0I88_RS00725	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
H0I88_RS00735	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0I88_RS00740	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
H0I88_RS00745	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
H0I88_RS00755	ENOG410821X	50S ribosomal protein L17
H0I88_RS00760	ENOG4105DFF	Rod shape-determining protein mreb
H0I88_RS00765	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
H0I88_RS00775	ENOG4105CJN	penicillin-binding protein
H0I88_RS00780	ENOG4105CNI	cell division protein FtsW
H0I88_RS00795	ENOG4105DDQ	anthranilate synthase
H0I88_RS00800	ENOG4108I0Q	anthranilate phosphoribosyltransferase
H0I88_RS00810	ENOG4105DK0	Indole-3-glycerol phosphate synthase
H0I88_RS00815	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
H0I88_RS00825	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
H0I88_RS00870	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
H0I88_RS00880	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
H0I88_RS00885	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
H0I88_RS00890	ENOG4105D7N	magnesium and cobalt transport protein CorA
H0I88_RS00895	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
H0I88_RS00915	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
H0I88_RS00920	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
H0I88_RS00945	ENOG4108Z03	MAF-like protein
H0I88_RS00950	ENOG4105DBV	ornithine carbamoyltransferase
H0I88_RS00960	ENOG4105WJX	transcriptional regulator MERR family
H0I88_RS00965	ENOG4105K70	DNA-binding protein
H0I88_RS00970	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
H0I88_RS00975	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
H0I88_RS01000	ENOG4105BZA	Phosphoglycerate kinase
H0I88_RS01035	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
H0I88_RS01045	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
H0I88_RS01050	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
H0I88_RS01075	ENOG4105C3G	gtp-binding protein
H0I88_RS01085	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
H0I88_RS01115	ENOG4105EYU	Glutamine amido-transferase
H0I88_RS01120	ENOG4105CBC	glutamate synthase
H0I88_RS01125	ENOG4105BZ8	glutamate synthase
H0I88_RS01160	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
H0I88_RS01165	ENOG41086C8	30S ribosomal protein S15
H0I88_RS01170	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
H0I88_RS01175	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
H0I88_RS01180	ENOG4105CNU	cell division protein FtsK
H0I88_RS01200	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
H0I88_RS01205	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
H0I88_RS01210	ENOG4108ZAI	phosphatidylglycerophosphatase a
H0I88_RS01215	ENOG4105DR5	peptidase
H0I88_RS01230	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
H0I88_RS01235	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
H0I88_RS01240	ENOG4105CJN	penicillin-binding protein
H0I88_RS01250	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
H0I88_RS01255	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
H0I88_RS01260	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
H0I88_RS01265	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
H0I88_RS01270	ENOG41082DI	50s ribosomal protein l31
H0I88_RS01275	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
H0I88_RS01280	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
H0I88_RS01300	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
H0I88_RS01315	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
H0I88_RS01325	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
H0I88_RS01330	ENOG4105DC7	peptidase M24
H0I88_RS01335	ENOG4105VEQ	Cold shock protein
H0I88_RS01340	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
H0I88_RS01345	ENOG4105D49	3-dehydroquinate synthase
H0I88_RS01375	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0I88_RS01380	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
H0I88_RS01385	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
H0I88_RS01390	ENOG4108IYU	L-aspartate oxidase
H0I88_RS01395	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
H0I88_RS01415	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
H0I88_RS01425	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
H0I88_RS01430	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
H0I88_RS01450	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
H0I88_RS01460	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
H0I88_RS01465	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
H0I88_RS01470	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
H0I88_RS01475	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
H0I88_RS01505	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
H0I88_RS01510	ENOG4105KCF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
H0I88_RS01530	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
H0I88_RS01555	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
H0I88_RS01560	ENOG4107KXI	50S ribosomal protein L33
H0I88_RS01575	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
H0I88_RS01585	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
H0I88_RS01590	ENOG4108396	Required for maturation of 30S ribosomal subunits (By similarity)
H0I88_RS01595	ENOG4105CHV	Transcription elongation factor NusA
H0I88_RS01600	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
H0I88_RS01605	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
H0I88_RS01610	ENOG4105SFS	phosphoesterase RecJ domain protein
H0I88_RS01615	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
H0I88_RS01620	ENOG4105DTN	riboflavin biosynthesis protein ribF
H0I88_RS01625	ENOG4107YU2	histidine triad (hIT) protein
H0I88_RS01630	ENOG4108754	30S ribosomal protein S21
H0I88_RS01640	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
H0I88_RS01645	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
H0I88_RS01685	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
H0I88_RS01690	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
H0I88_RS01695	ENOG4105C22	threonyL-tRNA synthetase
H0I88_RS01735	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
H0I88_RS01740	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
H0I88_RS01745	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
H0I88_RS01750	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
H0I88_RS01755	ENOG4105C5R	Aminotransferase
H0I88_RS01765	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
H0I88_RS01775	ENOG4105CXY	transporter
H0I88_RS01780	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
H0I88_RS01815	ENOG4105VCQ	rubredoxin
H0I88_RS01825	ENOG4107RIU	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity)
H0I88_RS01830	ENOG4105CNW	domain protein
H0I88_RS01840	ENOG4108RAC	Rubrerythrin
H0I88_RS01845	ENOG4108RWN	rrna methyltransferase
H0I88_RS01865	ENOG4105BZ1	(ABC) transporter
H0I88_RS01930	ENOG4105C6E	dna polymerase iii
H0I88_RS01940	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
H0I88_RS01945	ENOG4105EJ5	oxidoreductase gamma subunit
H0I88_RS01955	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
H0I88_RS01960	ENOG4105DDK	oxidoreductase, beta subunit
H0I88_RS01965	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
H0I88_RS01970	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
H0I88_RS01985	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
H0I88_RS01995	ENOG4105D2N	Aldolase
H0I88_RS02000	ENOG4105C6K	Malic enzyme
H0I88_RS02005	ENOG4106DSS	Tartrate dehydratase subunit alpha
H0I88_RS02035	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
H0I88_RS02040	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
H0I88_RS02045	ENOG41084H3	Ribosomal protein L35
H0I88_RS02050	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
H0I88_RS02075	ENOG4107ZYR	domain protein
H0I88_RS02095	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
H0I88_RS02100	ENOG4105CQB	FAD linked oxidase domain protein
H0I88_RS02115	ENOG4105C31	Tryptophanyl-tRNA synthetase
H0I88_RS02125	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
H0I88_RS02160	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
H0I88_RS02190	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
H0I88_RS02200	ENOG4105CTQ	phosphohexokinase
H0I88_RS02205	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
H0I88_RS02210	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
H0I88_RS02215	ENOG4105BZ8	glutamate synthase
H0I88_RS02230	ENOG4105CP7	Triose-phosphate isomerase
H0I88_RS02235	ENOG4108YZG	isomerase
H0I88_RS02245	ENOG4108HHA	Transketolase
H0I88_RS02250	ENOG4108IUS	Transketolase
H0I88_RS02260	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
H0I88_RS02265	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
H0I88_RS02275	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
H0I88_RS02295	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
H0I88_RS02300	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
H0I88_RS02305	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
H0I88_RS02310	ENOG4108793	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
H0I88_RS02315	ENOG4105CTB	Polyprenyl synthetase
H0I88_RS02320	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
H0I88_RS02335	ENOG4105DX0	Hemolysin A
H0I88_RS02340	ENOG4105C8T	Leucyl-tRNA synthetase
H0I88_RS02360	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
H0I88_RS02365	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
H0I88_RS02375	ENOG4105C9M	aspartyl-trna synthetase
H0I88_RS02385	ENOG41080AX	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
H0I88_RS02400	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
H0I88_RS02415	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
H0I88_RS02420	ENOG4107QW8	radical SAM domain protein
H0I88_RS02440	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
H0I88_RS02455	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
H0I88_RS02460	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
H0I88_RS02485	ENOG4105Q2H	domain protein
H0I88_RS02495	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
H0I88_RS02500	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
H0I88_RS02505	ENOG4105FA2	dna polymerase iii
H0I88_RS02510	ENOG4105MA4	psp1 domain protein
H0I88_RS02515	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
H0I88_RS02555	ENOG4105F8V	Hydrolase, tatD family
H0I88_RS02570	ENOG41069ER	domain protein
H0I88_RS02590	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
H0I88_RS02595	ENOG4107XPB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H0I88_RS02600	ENOG4105CFG	Acts as a chaperone (By similarity)
H0I88_RS02610	ENOG41082BG	Binds together with S18 to 16S ribosomal RNA (By similarity)
H0I88_RS02620	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
H0I88_RS02625	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
H0I88_RS02630	ENOG4105CDU	Replicative dna helicase
H0I88_RS02635	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
H0I88_RS02655	ENOG4105CSA	Coproporphyrinogen iii oxidase
H0I88_RS02660	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
H0I88_RS02665	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
H0I88_RS02675	ENOG4108317	Binds directly to 16S ribosomal RNA (By similarity)
H0I88_RS02680	ENOG4105D06	uba thif-type nad fad binding protein
H0I88_RS02690	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
H0I88_RS02710	ENOG4107X4V	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
H0I88_RS02715	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
H0I88_RS02725	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
H0I88_RS02740	ENOG4105CNI	cell division protein FtsW
H0I88_RS02745	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
H0I88_RS02750	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
H0I88_RS02755	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
H0I88_RS02760	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
H0I88_RS02795	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
H0I88_RS02800	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
H0I88_RS02825	ENOG4105DHP	deoxycytidine triphosphate deaminase
H0I88_RS02830	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
H0I88_RS02835	ENOG4105DJH	phosphate
H0I88_RS02840	ENOG4105C8U	phosphate abc transporter
H0I88_RS02845	ENOG4105E2Z	phosphate ABC transporter (Permease
H0I88_RS02850	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
H0I88_RS02855	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
H0I88_RS02860	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
H0I88_RS02865	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
H0I88_RS02870	ENOG4105W5Q	DNA repair protein (RadC
H0I88_RS02905	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
H0I88_RS02910	ENOG4105CE9	30S ribosomal protein S2
H0I88_RS02915	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
H0I88_RS02925	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
H0I88_RS02930	ENOG4108ZNS	ferredoxin-type protein NapF
H0I88_RS02935	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
H0I88_RS02940	ENOG4105KNE	Phosphatidate cytidylyltransferase
H0I88_RS02945	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
H0I88_RS02950	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
H0I88_RS02955	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
H0I88_RS02960	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
H0I88_RS03000	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
H0I88_RS03020	ENOG4107QP8	phosphohexose isomerase
H0I88_RS03025	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
H0I88_RS03030	ENOG4105M7K	Involved in the transcription termination process (By similarity)
H0I88_RS03035	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
H0I88_RS03050	ENOG410902V	Modulates RecA activity (By similarity)
H0I88_RS03055	ENOG4105DC1	bifunctional purine biosynthesis protein purh
H0I88_RS03060	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
H0I88_RS03075	ENOG4108JA2	transcriptioN-repair coupling factor
H0I88_RS03080	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
H0I88_RS03085	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
H0I88_RS03090	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
H0I88_RS03105	ENOG4108IUZ	ABC transporter
H0I88_RS03110	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
H0I88_RS03115	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
H0I88_RS03125	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
H0I88_RS03130	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
H0I88_RS03140	ENOG4108IQ3	PTS system
H0I88_RS03150	ENOG4105F3R	pts system mannose fructose sorbose family iid
H0I88_RS03155	ENOG4105KZ7	phosphocarrier protein hpr
H0I88_RS03165	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
H0I88_RS03170	ENOG4105C3F	Signal peptidase i
H0I88_RS03200	ENOG4105EHG	Permease protein
H0I88_RS03205	ENOG4105E0A	ABC, transporter
H0I88_RS03245	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
H0I88_RS03255	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
H0I88_RS03260	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
H0I88_RS03265	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
H0I88_RS03270	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
H0I88_RS03275	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
H0I88_RS03285	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
H0I88_RS03290	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
H0I88_RS03295	ENOG4105JFG	SpoIID LytB domain protein
H0I88_RS03305	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
H0I88_RS03320	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
H0I88_RS03325	ENOG4105CDY	transcriptional regulatory protein
H0I88_RS03330	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
H0I88_RS03335	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
H0I88_RS03340	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
H0I88_RS03345	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
H0I88_RS03360	ENOG4105VH4	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
H0I88_RS03365	ENOG4107WJT	it plays a direct role in the translocation of protons across the membrane (By similarity)
H0I88_RS03370	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
H0I88_RS03380	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
H0I88_RS03385	ENOG4105CJR	Integral membrane protein (MviN
H0I88_RS03405	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
H0I88_RS03410	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
H0I88_RS03415	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
H0I88_RS03450	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
H0I88_RS03455	ENOG4105E4C	Lytic transglycosylase catalytic
H0I88_RS03460	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
H0I88_RS03490	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
H0I88_RS03520	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
H0I88_RS03535	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
H0I88_RS03540	ENOG4108IDZ	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
H0I88_RS03545	ENOG4105C2X	Arabinose 5-phosphate isomerase
H0I88_RS03550	ENOG4105C2X	Arabinose 5-phosphate isomerase
H0I88_RS03575	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
H0I88_RS03580	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
H0I88_RS03585	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
H0I88_RS03590	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
H0I88_RS03595	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
H0I88_RS03600	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
H0I88_RS03605	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
H0I88_RS03610	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
H0I88_RS03615	ENOG4105K8N	protein family UPF0079, ATPase
H0I88_RS03620	ENOG41072GX	Peptidase M22 Glycoprotease
H0I88_RS03700	ENOG4105D64	Mechanosensitive ion channel
H0I88_RS03710	ENOG4105CXN	decarboxylase
H0I88_RS03730	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
H0I88_RS03760	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
H0I88_RS03765	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
H0I88_RS03775	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
H0I88_RS03780	ENOG4108VPT	UPF0234 protein
H0I88_RS03785	ENOG4107QI6	Cysteine desulfurase
H0I88_RS03795	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
H0I88_RS03800	ENOG4107QHI	-hydrogenase
H0I88_RS03805	ENOG4107QIZ	NADH dehydrogenase
H0I88_RS03810	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
H0I88_RS03820	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
H0I88_RS03825	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
H0I88_RS03840	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
H0I88_RS03845	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
H0I88_RS03850	ENOG4108R6K	riboflavin synthase, subunit alpha
H0I88_RS03855	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
H0I88_RS03875	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H0I88_RS03880	ENOG4105K46	50S ribosomal protein l27
H0I88_RS03885	ENOG4107Y7S	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
H0I88_RS03895	ENOG4105CUT	histidyl-tRNA synthetase
H0I88_RS03915	ENOG4108JQC	penicillin-binding protein 1A
H0I88_RS03920	ENOG4105C03	ribonuclease
H0I88_RS03935	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
H0I88_RS03940	ENOG4105EVN	Prephenate dehydrogenase
H0I88_RS03945	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
H0I88_RS03950	ENOG4105CIH	Imidazole acetol-phosphate transaminase
H0I88_RS03955	ENOG4105CQC	Prephenate dehydratase
H0I88_RS03985	ENOG4108DWA	Nad synthetase
H0I88_RS03990	ENOG4105C25	Primosomal protein n'
H0I88_RS03995	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
H0I88_RS04000	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
H0I88_RS04005	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
H0I88_RS04015	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
H0I88_RS04025	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
H0I88_RS04030	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
H0I88_RS04035	ENOG4105CHR	reductase
H0I88_RS04040	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
H0I88_RS04045	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
H0I88_RS04050	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
H0I88_RS04055	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
H0I88_RS04065	ENOG4105CDH	Citrulline--aspartate ligase
H0I88_RS04070	ENOG4105C8Y	Acetylornithine aminotransferase
H0I88_RS04085	ENOG4107RRU	Involved in both the arginine and lysine biosynthetic pathways (By similarity)
H0I88_RS04095	ENOG4106H78	methyltransferase
H0I88_RS04115	ENOG4105D6E	homoserine dehydrogenase
H0I88_RS04125	ENOG4107RJF	diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)
H0I88_RS04160	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
H0I88_RS04165	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
H0I88_RS04180	ENOG4107QT7	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
H0I88_RS04185	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
H0I88_RS04195	ENOG4105VIE	preprotein translocase, subunit YajC
H0I88_RS04280	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
H0I88_RS04290	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
H0I88_RS04295	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
H0I88_RS04310	ENOG4105F1A	Pyruvate formate-lyase
H0I88_RS04315	ENOG4105C3R	Methionine synthase
H0I88_RS04330	ENOG4108Z6B	deaminase
H0I88_RS04350	ENOG4105CE1	Ferrous iron transport protein b
H0I88_RS04395	ENOG4108IAJ	Nad-dependent epimerase dehydratase
H0I88_RS04405	ENOG4105C0A	alcohol dehydrogenase
H0I88_RS04410	ENOG4105C10	Electron transfer flavoprotein
H0I88_RS04415	ENOG4105BZJ	Electron transfer flavoprotein
H0I88_RS04420	ENOG4105C1G	acyl-Coa dehydrogenase
H0I88_RS04425	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
H0I88_RS04430	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
H0I88_RS04435	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
H0I88_RS04440	ENOG4105CHR	reductase
H0I88_RS04445	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
H0I88_RS04450	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
H0I88_RS04455	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
H0I88_RS04460	ENOG41067VY	50S ribosomal protein L32
H0I88_RS04475	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
H0I88_RS04505	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
H0I88_RS04515	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
H0I88_RS04530	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
H0I88_RS04535	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
H0I88_RS04560	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0I88_RS04565	ENOG4105CWE	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
H0I88_RS04575	ENOG4105W3H	MtN3 and saliva related transmembrane protein
H0I88_RS04580	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
H0I88_RS04585	ENOG4105C34	Pseudouridine synthase
H0I88_RS04590	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
H0I88_RS04595	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
H0I88_RS04605	ENOG410864U	UPF0235 protein
H0I88_RS04610	ENOG4105DFA	alanine racemase domain protein
H0I88_RS04640	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
H0I88_RS04665	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
H0I88_RS04690	ENOG4105DB7	PHP domain protein
H0I88_RS04700	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
H0I88_RS04710	ENOG4105GRF	N-glycosylase DNA lyase
H0I88_RS04725	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
H0I88_RS04735	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
H0I88_RS04740	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
H0I88_RS04745	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
H0I88_RS04750	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
H0I88_RS04760	ENOG4105CPF	Cell wall formation (By similarity)
H0I88_RS04770	ENOG4105DFU	Cell wall formation (By similarity)
H0I88_RS04775	ENOG4105CHM	Aminotransferase
H0I88_RS04780	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
H0I88_RS04785	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
H0I88_RS04790	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
H0I88_RS04795	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
H0I88_RS04805	ENOG4105CH7	arginosuccinase
H0I88_RS04815	ENOG4105CM2	brancheD-chain amino acid aminotransferase
H0I88_RS04820	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
H0I88_RS04825	ENOG4105D60	lipoprotein releasing system transmembrane protein
H0I88_RS04830	ENOG4105CRK	lysyL-tRNA synthetase
H0I88_RS04895	ENOG4105MJ2	Competence protein
H0I88_RS04925	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
H0I88_RS04930	ENOG4105C8M	UPF0272 protein
H0I88_RS04935	ENOG4105DVM	PP-loop domain protein
H0I88_RS04945	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
H0I88_RS04950	ENOG4107VMB	Beta-lactamase domain protein
H0I88_RS04970	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
H0I88_RS04980	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
H0I88_RS04985	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
H0I88_RS04995	ENOG4107QXC	3-phosphoshikimate 1-carboxyvinyltransferase
H0I88_RS05015	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
H0I88_RS05020	ENOG4105CIH	Imidazole acetol-phosphate transaminase
H0I88_RS05025	ENOG4105CQC	Prephenate dehydratase
H0I88_RS05035	ENOG4105ECY	inositol monophosphatase
H0I88_RS05045	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
H0I88_RS05055	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
H0I88_RS05060	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
H0I88_RS05070	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
H0I88_RS05075	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
H0I88_RS05110	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
H0I88_RS05115	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
H0I88_RS05135	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
H0I88_RS05140	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
H0I88_RS05145	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
H0I88_RS05150	ENOG4105DJV	ribulose-phosphate 3-epimerase
H0I88_RS05160	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
H0I88_RS05165	ENOG4108ZP8	Acetolactate synthase small subunit
H0I88_RS05170	ENOG4105C7K	acetolactate synthase
H0I88_RS05175	ENOG4105C01	Dihydroxy-acid dehydratase
H0I88_RS05185	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
H0I88_RS05190	ENOG4108UJD	30S ribosomal protein S9
H0I88_RS05195	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
H0I88_RS05200	ENOG4105C2N	RNA methyltransferase TrmH family group 3
H0I88_RS05205	ENOG4105C8N	cysteinyl-tRNA synthetase
H0I88_RS05210	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
H0I88_RS05215	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
H0I88_RS05220	ENOG4105E2X	shikimate dehydrogenase
H0I88_RS05235	ENOG4105CGY	Dna recombination protein
H0I88_RS05240	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
H0I88_RS05245	ENOG4105CA9	Pyruvate kinase
H0I88_RS05280	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H0I88_RS05285	ENOG4105DXN	mazG family
H0I88_RS05305	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
H0I88_RS05310	ENOG4107UH2	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
H0I88_RS05320	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
H0I88_RS05345	ENOG4105CY0	Metallo-Beta-Lactamase
H0I88_RS05380	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
H0I88_RS05385	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0I88_RS05425	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0I88_RS05430	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
H0I88_RS05435	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
H0I88_RS05460	ENOG4107RN3	metallophosphoesterase
H0I88_RS05475	ENOG4105C4R	Atp-dependent dna helicase
H0I88_RS05485	ENOG4105C75	arginyL-tRNA synthetase
H0I88_RS05490	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
H0I88_RS05495	ENOG4105C8J	)-transporter
H0I88_RS05535	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
H0I88_RS05545	ENOG4105CFH	Aspartokinase
H0I88_RS05550	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
H0I88_RS05590	ENOG4105C44	Serine transporter
H0I88_RS05595	ENOG4105C83	adenylosuccinate lyase
H0I88_RS05600	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
H0I88_RS05610	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
H0I88_RS05625	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
H0I88_RS05630	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
H0I88_RS05635	ENOG4107TYT	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
H0I88_RS05650	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
H0I88_RS05655	ENOG4105CD3	dihydroorotase
H0I88_RS05660	ENOG4105CXT	aspartate transcarbamylase
H0I88_RS05665	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
H0I88_RS05670	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
H0I88_RS05675	ENOG4107QNG	Phosphoribosylglycinamide synthetase
H0I88_RS05690	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
H0I88_RS05695	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
H0I88_RS05705	ENOG4105C8V	SAICAR synthetase
H0I88_RS05725	ENOG4105C1J	atp-dependent rna helicase
H0I88_RS05735	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
H0I88_RS05740	ENOG4105DZP	Membrane-associated zinc metalloprotease
H0I88_RS05745	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)