locus-tag	class	description
H0I88_RS00045	COG0592	DNA-directed DNA polymerase activity
H0I88_RS00055	COG0187	DNA topoisomerase II activity
H0I88_RS00060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H0I88_RS00065	COG1113	amino acid transport
H0I88_RS00095	COG3118	belongs to the thioredoxin family
H0I88_RS00115	COG0492	ferredoxin-NADP+ reductase activity
H0I88_RS00120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0I88_RS00120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0I88_RS00125	COG0237	dephospho-CoA kinase activity
H0I88_RS00130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H0I88_RS00175	COG0792	nuclease activity
H0I88_RS00185	COG0335	large ribosomal subunit rRNA binding
H0I88_RS00195	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0I88_RS00200	COG1837	Belongs to the UPF0109 family
H0I88_RS00215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0I88_RS00230	COG1704	LemA family
H0I88_RS00245	COG0708	Exodeoxyribonuclease III
H0I88_RS00255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H0I88_RS00265	COG0494	nUDIX hydrolase
H0I88_RS00275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0I88_RS00360	COG0577	efflux transmembrane transporter activity
H0I88_RS00360	COG1136	(ABC) transporter
H0I88_RS00365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0I88_RS00380	COG0594	ribonuclease P activity
H0I88_RS00395	COG1847	R3H domain protein
H0I88_RS00400	COG1832	CoA-binding protein
H0I88_RS00405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0I88_RS00410	COG1192	Involved in chromosome partitioning
H0I88_RS00415	COG1475	DNA binding
H0I88_RS00420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0I88_RS00445	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H0I88_RS00485	COG0617	tRNA 3'-terminal CCA addition
H0I88_RS00495	COG0612	Peptidase, M16
H0I88_RS00500	COG2814	Major facilitator Superfamily
H0I88_RS00510	COG1028	Short-chain dehydrogenase reductase Sdr
H0I88_RS00525	COG0800	Aldolase
H0I88_RS00570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0I88_RS00580	COG0085	RNA polymerase activity
H0I88_RS00605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0I88_RS00610	COG0051	transcription antitermination factor activity, RNA binding
H0I88_RS00620	COG0088	Forms part of the polypeptide exit tunnel
H0I88_RS00655	COG0255	Belongs to the universal ribosomal protein uL29 family
H0I88_RS00690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0I88_RS00700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0I88_RS00705	COG0200	Binds to the 23S rRNA
H0I88_RS00710	COG0201	protein transport
H0I88_RS00750	COG0202	RNA polymerase activity
H0I88_RS00760	COG1077	Cell shape determining protein MreB Mrl
H0I88_RS00775	COG0768	penicillin binding
H0I88_RS00780	COG0772	Belongs to the SEDS family
H0I88_RS00795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0I88_RS00795	COG0512	Glutamine amidotransferase of anthranilate synthase
H0I88_RS00825	COG0159	tryptophan synthase activity
H0I88_RS00870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0I88_RS00870	COG4651	solute:proton antiporter activity
H0I88_RS00890	COG0598	Magnesium transport protein CorA
H0I88_RS00895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0I88_RS00915	COG1074	ATP-dependent DNA helicase activity
H0I88_RS00920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H0I88_RS00950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H0I88_RS00965	COG0776	regulation of translation
H0I88_RS00970	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H0I88_RS01000	COG0126	phosphoglycerate kinase activity
H0I88_RS01005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0I88_RS01035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H0I88_RS01045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H0I88_RS01050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H0I88_RS01075	COG0012	GTP binding
H0I88_RS01085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0I88_RS01105	COG0517	IMP dehydrogenase activity
H0I88_RS01105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0I88_RS01105	COG0617	tRNA 3'-terminal CCA addition
H0I88_RS01115	COG0067	glutamate synthase
H0I88_RS01120	COG0069	glutamate synthase activity
H0I88_RS01130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0I88_RS01160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0I88_RS01175	COG0511	ligase activity, forming carbon-carbon bonds
H0I88_RS01180	COG1674	ftsk spoiiie
H0I88_RS01205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0I88_RS01210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0I88_RS01215	COG0739	heme binding
H0I88_RS01230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0I88_RS01250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0I88_RS01255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0I88_RS01265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0I88_RS01270	COG0254	rRNA binding
H0I88_RS01280	COG2890	protein-(glutamine-N5) methyltransferase activity
H0I88_RS01300	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H0I88_RS01315	COG0439	Biotin carboxylase
H0I88_RS01330	COG0006	proline dipeptidase activity
H0I88_RS01335	COG1278	Cold shock
H0I88_RS01375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0I88_RS01395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0I88_RS01415	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H0I88_RS01420	COG0392	lysyltransferase activity
H0I88_RS01425	COG0037	tRNA processing
H0I88_RS01435	COG0302	gtp cyclohydrolase
H0I88_RS01450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0I88_RS01460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0I88_RS01465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0I88_RS01470	COG0736	holo-[acyl-carrier-protein] synthase activity
H0I88_RS01475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0I88_RS01475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0I88_RS01505	COG1518	maintenance of DNA repeat elements
H0I88_RS01510	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H0I88_RS01520	COG1518	maintenance of DNA repeat elements
H0I88_RS01530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0I88_RS01555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0I88_RS01585	COG0081	regulation of translation
H0I88_RS01595	COG0195	Participates in both transcription termination and antitermination
H0I88_RS01600	COG3170	Tfp pilus assembly protein FimV
H0I88_RS01600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H0I88_RS01605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H0I88_RS01610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0I88_RS01620	COG0196	riboflavin kinase activity
H0I88_RS01625	COG0537	adenosine 5'-monophosphoramidase activity
H0I88_RS01640	COG0358	DNA primase activity
H0I88_RS01645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0I88_RS01685	COG0752	glycyl-tRNA synthetase alpha subunit
H0I88_RS01690	COG0751	glycine-tRNA ligase activity
H0I88_RS01695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H0I88_RS01745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H0I88_RS01755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H0I88_RS01760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H0I88_RS01765	COG0504	CTP synthase activity
H0I88_RS01775	COG2271	Major facilitator Superfamily
H0I88_RS01780	COG0714	Associated with various cellular activities
H0I88_RS01815	COG1773	rubredoxin
H0I88_RS01825	COG0822	iron-sulfur transferase activity
H0I88_RS01830	COG0426	domain, Protein
H0I88_RS01840	COG1592	Rubrerythrin
H0I88_RS01845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0I88_RS01865	COG1132	(ABC) transporter
H0I88_RS01930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0I88_RS01945	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H0I88_RS01955	COG0674	pyruvate-flavodoxin oxidoreductase activity
H0I88_RS01960	COG1013	pyruvate-flavodoxin oxidoreductase activity
H0I88_RS01970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H0I88_RS02000	COG0281	malic enzyme
H0I88_RS02005	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H0I88_RS02045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H0I88_RS02050	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H0I88_RS02055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0I88_RS02065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0I88_RS02075	COG0569	domain protein
H0I88_RS02080	COG0569	domain protein
H0I88_RS02095	COG0072	phenylalanine-tRNA ligase activity
H0I88_RS02100	COG0277	FAD linked oxidase domain protein
H0I88_RS02115	COG0180	Tryptophanyl-tRNA synthetase
H0I88_RS02125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H0I88_RS02165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0I88_RS02190	COG0823	Involved in the tonB-independent uptake of proteins
H0I88_RS02200	COG0205	6-phosphofructokinase activity
H0I88_RS02205	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0I88_RS02210	COG0543	2 iron, 2 sulfur cluster binding
H0I88_RS02215	COG0493	'glutamate synthase
H0I88_RS02235	COG0698	ribose 5-phosphate isomerase
H0I88_RS02245	COG3959	Transketolase, thiamine diphosphate binding domain
H0I88_RS02250	COG3958	Transketolase
H0I88_RS02260	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H0I88_RS02265	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H0I88_RS02295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0I88_RS02305	COG1570	exodeoxyribonuclease VII activity
H0I88_RS02315	COG0142	geranyltranstransferase activity
H0I88_RS02320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0I88_RS02335	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H0I88_RS02340	COG0495	leucyl-tRNA aminoacylation
H0I88_RS02360	COG1183	phosphatidylcholine synthase activity
H0I88_RS02365	COG0105	UTP biosynthetic process
H0I88_RS02400	COG1381	Involved in DNA repair and RecF pathway recombination
H0I88_RS02420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H0I88_RS02460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0I88_RS02480	COG0280	phosphate acetyltransferase
H0I88_RS02485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H0I88_RS02495	COG0501	Belongs to the peptidase M48B family
H0I88_RS02500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H0I88_RS02505	COG0470	DNA polymerase III
H0I88_RS02510	COG1774	PSP1 C-terminal conserved region
H0I88_RS02515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I88_RS02515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0I88_RS02555	COG0084	hydrolase, TatD family'
H0I88_RS02570	COG3584	3D domain protein
H0I88_RS02570	COG1388	LysM domain
H0I88_RS02590	COG1420	regulation of RNA biosynthetic process
H0I88_RS02595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H0I88_RS02605	COG0484	heat shock protein binding
H0I88_RS02610	COG0360	Binds together with S18 to 16S ribosomal RNA
H0I88_RS02630	COG0305	Participates in initiation and elongation during chromosome replication
H0I88_RS02635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0I88_RS02645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0I88_RS02655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0I88_RS02665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H0I88_RS02675	COG0268	Binds directly to 16S ribosomal RNA
H0I88_RS02680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H0I88_RS02690	COG0352	thiamine-phosphate diphosphorylase activity
H0I88_RS02700	COG2022	thiamine diphosphate biosynthetic process
H0I88_RS02715	COG1418	mRNA catabolic process
H0I88_RS02725	COG0799	negative regulation of ribosome biogenesis
H0I88_RS02740	COG0772	Belongs to the SEDS family
H0I88_RS02745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0I88_RS02755	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0I88_RS02760	COG0556	nucleotide-excision repair
H0I88_RS02795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0I88_RS02800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0I88_RS02825	COG0717	Belongs to the dCTP deaminase family
H0I88_RS02830	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0I88_RS02830	COG0519	Catalyzes the synthesis of GMP from XMP
H0I88_RS02840	COG0573	inorganic phosphate transmembrane transporter activity
H0I88_RS02845	COG0581	inorganic phosphate transmembrane transporter activity
H0I88_RS02850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0I88_RS02855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0I88_RS02860	COG0704	Plays a role in the regulation of phosphate uptake
H0I88_RS02865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H0I88_RS02870	COG2003	Belongs to the UPF0758 family
H0I88_RS02915	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H0I88_RS02930	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0I88_RS02930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0I88_RS02935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0I88_RS02940	COG4589	Belongs to the CDS family
H0I88_RS02950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H0I88_RS02955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0I88_RS03000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H0I88_RS03030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0I88_RS03050	COG2137	regulation of response to DNA damage stimulus
H0I88_RS03055	COG0138	bifunctional purine biosynthesis protein purh
H0I88_RS03060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0I88_RS03075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0I88_RS03080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0I88_RS03085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H0I88_RS03090	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H0I88_RS03105	COG1137	ATPase activity
H0I88_RS03110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0I88_RS03115	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H0I88_RS03125	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H0I88_RS03140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0I88_RS03150	COG3716	PTS system mannose fructose sorbose family IID component
H0I88_RS03155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0I88_RS03165	COG0481	GTPase activity
H0I88_RS03170	COG0681	Belongs to the peptidase S26 family
H0I88_RS03195	COG4607	ABC-type enterochelin transport system periplasmic component
H0I88_RS03200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0I88_RS03205	COG1120	ATPase activity
H0I88_RS03245	COG0019	diaminopimelate decarboxylase activity
H0I88_RS03255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0I88_RS03260	COG0473	3-isopropylmalate dehydrogenase activity
H0I88_RS03285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0I88_RS03290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0I88_RS03295	COG2385	sporulation resulting in formation of a cellular spore
H0I88_RS03305	COG2255	four-way junction helicase activity
H0I88_RS03335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0I88_RS03340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H0I88_RS03345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H0I88_RS03360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0I88_RS03365	COG0356	it plays a direct role in the translocation of protons across the membrane
H0I88_RS03380	COG0322	excinuclease ABC activity
H0I88_RS03385	COG0728	peptidoglycan biosynthetic process
H0I88_RS03405	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H0I88_RS03450	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H0I88_RS03455	COG1196	nuclear chromosome segregation
H0I88_RS03455	COG0741	lytic transglycosylase activity
H0I88_RS03455	COG0739	heme binding
H0I88_RS03490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0I88_RS03520	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0I88_RS03535	COG0285	dihydrofolate synthase activity
H0I88_RS03545	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0I88_RS03545	COG0517	IMP dehydrogenase activity
H0I88_RS03550	COG0517	IMP dehydrogenase activity
H0I88_RS03550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0I88_RS03575	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0I88_RS03590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0I88_RS03600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0I88_RS03605	COG0658	competence protein
H0I88_RS03605	COG2333	competence protein COMEC
H0I88_RS03610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0I88_RS03615	COG0802	atpase or kinase
H0I88_RS03620	COG1214	PFAM Peptidase M22, glycoprotease
H0I88_RS03685	COG1132	(ABC) transporter
H0I88_RS03695	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H0I88_RS03700	COG0668	transmembrane transport
H0I88_RS03710	COG1982	Orn Lys Arg decarboxylase major
H0I88_RS03730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H0I88_RS03760	COG0497	DNA recombination
H0I88_RS03765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0I88_RS03775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H0I88_RS03785	COG1104	cysteine desulfurase activity
H0I88_RS03815	COG0475	glutathione-regulated potassium exporter activity
H0I88_RS03820	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H0I88_RS03850	COG0307	riboflavin synthase, alpha
H0I88_RS03855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0I88_RS03855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H0I88_RS03880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0I88_RS03915	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H0I88_RS03920	COG1530	ribonuclease E activity
H0I88_RS03940	COG0287	Prephenate dehydrogenase
H0I88_RS03945	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H0I88_RS03950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0I88_RS03955	COG0077	Prephenate dehydratase
H0I88_RS03955	COG1605	Chorismate mutase
H0I88_RS03985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0I88_RS03985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0I88_RS03990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0I88_RS03995	COG1573	uracil-dna glycosylase
H0I88_RS04005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H0I88_RS04015	COG0194	GDP metabolic process
H0I88_RS04025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H0I88_RS04030	COG0525	valine-tRNA ligase activity
H0I88_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
H0I88_RS04040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0I88_RS04045	COG0542	response to heat
H0I88_RS04055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H0I88_RS04060	COG0156	8-amino-7-oxononanoate synthase activity
H0I88_RS04070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0I88_RS04095	COG0742	ribosomal rna small subunit methyltransferase
H0I88_RS04115	COG0460	homoserine dehydrogenase
H0I88_RS04125	COG0205	6-phosphofructokinase activity
H0I88_RS04160	COG1519	Transferase
H0I88_RS04160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0I88_RS04165	COG1519	Transferase
H0I88_RS04165	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0I88_RS04195	COG1862	Preprotein translocase
H0I88_RS04280	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H0I88_RS04290	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H0I88_RS04295	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0I88_RS04310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H0I88_RS04315	COG0646	methionine synthase
H0I88_RS04315	COG1410	methionine synthase
H0I88_RS04325	COG0824	Thioesterase
H0I88_RS04350	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H0I88_RS04350	COG1918	ferrous iron import across plasma membrane
H0I88_RS04380	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0I88_RS04390	COG0456	acetyltransferase
H0I88_RS04395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0I88_RS04405	COG1454	alcohol dehydrogenase
H0I88_RS04405	COG1012	belongs to the aldehyde dehydrogenase family
H0I88_RS04410	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H0I88_RS04415	COG2086	electron transfer activity
H0I88_RS04420	COG1960	acyl-CoA dehydrogenase activity
H0I88_RS04425	COG0571	ribonuclease III activity
H0I88_RS04430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0I88_RS04440	COG1028	Short-chain dehydrogenase reductase Sdr
H0I88_RS04445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0I88_RS04450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0I88_RS04460	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H0I88_RS04465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0I88_RS04475	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I88_RS04505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0I88_RS04515	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0I88_RS04530	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H0I88_RS04535	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H0I88_RS04560	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0I88_RS04575	COG4095	Psort location CytoplasmicMembrane, score
H0I88_RS04580	COG0357	Ribosomal RNA small subunit methyltransferase G
H0I88_RS04585	COG0564	pseudouridine synthase activity
H0I88_RS04610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H0I88_RS04635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0I88_RS04640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0I88_RS04665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0I88_RS04690	COG0613	PHP domain protein
H0I88_RS04710	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
H0I88_RS04725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H0I88_RS04735	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H0I88_RS04735	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H0I88_RS04745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0I88_RS04760	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0I88_RS04775	COG0436	Aminotransferase
H0I88_RS04780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0I88_RS04790	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H0I88_RS04795	COG0019	diaminopimelate decarboxylase activity
H0I88_RS04805	COG0165	Argininosuccinate lyase
H0I88_RS04815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0I88_RS04820	COG1136	(ABC) transporter
H0I88_RS04830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H0I88_RS04895	COG1040	competence protein
H0I88_RS04925	COG1691	(AIR) carboxylase
H0I88_RS04935	COG1606	tRNA processing
H0I88_RS04945	COG4974	Belongs to the 'phage' integrase family
H0I88_RS04950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0I88_RS04970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H0I88_RS04970	COG0539	negative regulation of cytoplasmic translation
H0I88_RS04975	COG0539	negative regulation of cytoplasmic translation
H0I88_RS04980	COG2183	response to ionizing radiation
H0I88_RS04980	COG0539	negative regulation of cytoplasmic translation
H0I88_RS04985	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H0I88_RS05015	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H0I88_RS05020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0I88_RS05025	COG1605	Chorismate mutase
H0I88_RS05025	COG0077	Prephenate dehydratase
H0I88_RS05030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0I88_RS05055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0I88_RS05065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0I88_RS05065	COG0758	DNA mediated transformation
H0I88_RS05070	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H0I88_RS05075	COG4974	Belongs to the 'phage' integrase family
H0I88_RS05120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0I88_RS05135	COG0720	synthase
H0I88_RS05140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0I88_RS05150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0I88_RS05160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0I88_RS05165	COG0440	acetolactate synthase activity
H0I88_RS05170	COG0028	Belongs to the TPP enzyme family
H0I88_RS05185	COG0516	GMP reductase activity
H0I88_RS05185	COG0517	IMP dehydrogenase activity
H0I88_RS05190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0I88_RS05195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0I88_RS05200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0I88_RS05220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H0I88_RS05235	COG1322	Protein conserved in bacteria
H0I88_RS05240	COG0328	RNA-DNA hybrid ribonuclease activity
H0I88_RS05245	COG0469	pyruvate kinase activity
H0I88_RS05280	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H0I88_RS05285	COG3956	TIGRFAM MazG family protein
H0I88_RS05305	COG0193	aminoacyl-tRNA hydrolase activity
H0I88_RS05320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0I88_RS05345	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H0I88_RS05430	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H0I88_RS05430	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H0I88_RS05435	COG0352	thiamine-phosphate diphosphorylase activity
H0I88_RS05460	COG1408	metallophosphoesterase
H0I88_RS05475	COG0210	DNA helicase
H0I88_RS05485	COG0018	arginyl-trna synthetase
H0I88_RS05495	COG0733	neurotransmitter:sodium symporter activity
H0I88_RS05535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0I88_RS05550	COG0083	homoserine kinase activity
H0I88_RS05590	COG0814	amino acid
H0I88_RS05595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0I88_RS05600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0I88_RS05610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0I88_RS05625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0I88_RS05630	COG0284	orotidine-5'-phosphate decarboxylase activity
H0I88_RS05650	COG0543	2 iron, 2 sulfur cluster binding
H0I88_RS05670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H0I88_RS05675	COG0151	Belongs to the GarS family
H0I88_RS05690	COG0047	phosphoribosylformylglycinamidine synthase activity
H0I88_RS05695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0I88_RS05705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H0I88_RS05725	COG0513	Belongs to the DEAD box helicase family
H0I88_RS05740	COG0750	zinc metalloprotease
H0I88_RS05745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity