locus-tag	class	description
CR143_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CR143_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CR143_RS00020	COG0187	DNA topoisomerase II activity
CR143_RS00045	COG0019	diaminopimelate decarboxylase activity
CR143_RS00050	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CR143_RS00055	COG1268	BioY protein
CR143_RS00060	COG1131	(ABC) transporter
CR143_RS00065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CR143_RS00065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CR143_RS00070	COG0745	RESPONSE REGULATOR receiver
CR143_RS00075	COG2205	protein histidine kinase activity
CR143_RS00080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CR143_RS00085	COG0802	atpase or kinase
CR143_RS00100	COG0167	dihydroorotate dehydrogenase activity
CR143_RS00110	COG0730	response to heat
CR143_RS00115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CR143_RS00135	COG0484	heat shock protein binding
CR143_RS00145	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CR143_RS00150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CR143_RS00155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CR143_RS00160	COG0825	malonyl-CoA metabolic process
CR143_RS00165	COG0653	protein targeting
CR143_RS00170	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CR143_RS00205	COG0347	Belongs to the P(II) protein family
CR143_RS00210	COG0004	ammonium transporteR
CR143_RS00215	COG3158	transport of potassium into the cell
CR143_RS00235	COG1380	Effector of murein hydrolase LrgA
CR143_RS00240	COG1346	cytolysis
CR143_RS00245	COG3038	cytochrome b561
CR143_RS00280	COG0542	response to heat
CR143_RS00305	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CR143_RS00310	COG2755	lipolytic protein G-D-S-L family
CR143_RS00315	COG1136	(ABC) transporter
CR143_RS00325	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CR143_RS00350	COG0183	Belongs to the thiolase family
CR143_RS00355	COG1024	Enoyl-CoA hydratase
CR143_RS00360	COG0596	Alpha beta hydrolase
CR143_RS00375	COG2224	Isocitrate lyase
CR143_RS00405	COG3046	protein related to deoxyribodipyrimidine photolyase
CR143_RS00415	COG1028	Short-chain dehydrogenase reductase Sdr
CR143_RS00425	COG0861	Integral membrane protein TerC family
CR143_RS00430	COG0861	Integral membrane protein TerC family
CR143_RS00470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CR143_RS00470	COG4651	solute:proton antiporter activity
CR143_RS00485	COG2885	chlorophyll binding
CR143_RS00490	COG2264	protein methyltransferase activity
CR143_RS00565	COG0642	Histidine kinase
CR143_RS00575	COG0318	PFAM AMP-dependent synthetase and ligase
CR143_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
CR143_RS00595	COG0659	secondary active sulfate transmembrane transporter activity
CR143_RS00600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CR143_RS00610	COG3223	Belongs to the PsiE family
CR143_RS00620	COG2133	pyrroloquinoline quinone binding
CR143_RS00625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CR143_RS00635	COG0123	including yeast histone deacetylase and acetoin utilization protein
CR143_RS00730	COG2925	Exonuclease
CR143_RS00735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CR143_RS00740	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CR143_RS00750	COG0285	dihydrofolate synthase activity
CR143_RS00755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CR143_RS00760	COG0159	tryptophan synthase activity
CR143_RS00765	COG0133	tryptophan synthase activity
CR143_RS00770	COG0135	phosphoribosylanthranilate isomerase activity
CR143_RS00775	COG0284	orotidine-5'-phosphate decarboxylase activity
CR143_RS00785	COG0539	negative regulation of cytoplasmic translation
CR143_RS00790	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CR143_RS00795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CR143_RS00860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CR143_RS00870	COG2391	methyltransferase activity
CR143_RS00875	COG2897	thiosulfate sulfurtransferase activity
CR143_RS00880	COG1522	sequence-specific DNA binding
CR143_RS00910	COG1902	pentaerythritol trinitrate reductase activity
CR143_RS00915	COG1051	belongs to the nudix hydrolase family
CR143_RS00930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CR143_RS00935	COG0527	aspartate kinase activity
CR143_RS00940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CR143_RS00945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CR143_RS00950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CR143_RS00950	COG2890	protein-(glutamine-N5) methyltransferase activity
CR143_RS00960	COG0739	heme binding
CR143_RS01025	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CR143_RS01030	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CR143_RS01035	COG1028	Short-chain dehydrogenase reductase Sdr
CR143_RS01045	COG1132	(ABC) transporter
CR143_RS01055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CR143_RS01070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CR143_RS01080	COG1086	Polysaccharide biosynthesis protein
CR143_RS01100	COG2226	methyltransferase
CR143_RS01145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CR143_RS01160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CR143_RS01180	COG1216	Glycosyl transferase, family 2
CR143_RS01185	COG0438	transferase activity, transferring glycosyl groups
CR143_RS01195	COG0438	transferase activity, transferring glycosyl groups
CR143_RS01215	COG0275	rRNA processing
CR143_RS01220	COG1215	transferase activity, transferring glycosyl groups
CR143_RS01240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CR143_RS01255	COG1215	transferase activity, transferring glycosyl groups
CR143_RS01270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CR143_RS01275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CR143_RS01285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CR143_RS01295	COG0772	Belongs to the SEDS family
CR143_RS01310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CR143_RS01315	COG0785	Cytochrome C biogenesis protein
CR143_RS01320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CR143_RS01330	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CR143_RS01335	COG0489	protein tyrosine kinase activity
CR143_RS01340	COG0330	HflC and HflK could
CR143_RS01345	COG0330	HflC and HflK could
CR143_RS01360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CR143_RS01365	COG0028	Belongs to the TPP enzyme family
CR143_RS01370	COG0440	acetolactate synthase activity
CR143_RS01375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CR143_RS01380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CR143_RS01390	COG1792	Involved in formation and maintenance of cell shape
CR143_RS01410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CR143_RS01420	COG0254	rRNA binding
CR143_RS01430	COG0483	inositol monophosphate 1-phosphatase activity
CR143_RS01435	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CR143_RS01440	COG0352	thiamine-phosphate diphosphorylase activity
CR143_RS01445	COG3588	fructose-bisphosphate aldolase
CR143_RS01450	COG0126	phosphoglycerate kinase activity
CR143_RS01470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CR143_RS01475	COG1692	metallophosphoesterase
CR143_RS01490	COG0824	Thioesterase
CR143_RS01510	COG0823	Involved in the tonB-independent uptake of proteins
CR143_RS01515	COG2885	chlorophyll binding
CR143_RS01530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CR143_RS01535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CR143_RS01540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CR143_RS01545	COG0351	phosphomethylpyrimidine kinase
CR143_RS01545	COG0352	thiamine-phosphate diphosphorylase activity
CR143_RS01550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CR143_RS01555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CR143_RS01560	COG0564	pseudouridine synthase activity
CR143_RS01570	COG0314	molybdopterin synthase activity
CR143_RS01580	COG0315	cyclic pyranopterin monophosphate synthase activity
CR143_RS01585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CR143_RS01605	COG0521	Mo-molybdopterin cofactor biosynthetic process
CR143_RS01610	COG0303	'Molybdopterin
CR143_RS01615	COG0746	molybdenum cofactor guanylyltransferase activity
CR143_RS01630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CR143_RS01635	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CR143_RS01640	COG3383	formate dehydrogenase (NAD+) activity
CR143_RS01665	COG1172	Belongs to the binding-protein-dependent transport system permease family
CR143_RS01675	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CR143_RS01685	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CR143_RS01705	COG0009	L-threonylcarbamoyladenylate synthase
CR143_RS01710	COG1722	exodeoxyribonuclease VII activity
CR143_RS01715	COG0142	geranyltranstransferase activity
CR143_RS01720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CR143_RS01740	COG0302	gtp cyclohydrolase
CR143_RS01750	COG0604	alcohol dehydrogenase
CR143_RS01765	COG0750	zinc metalloprotease
CR143_RS01770	COG0776	regulation of translation
CR143_RS01775	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CR143_RS01785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CR143_RS01790	COG0560	Phosphoserine phosphatase
CR143_RS01795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CR143_RS01800	COG1054	Belongs to the UPF0176 family
CR143_RS01815	COG2137	regulation of response to DNA damage stimulus
CR143_RS01840	COG0482	sulfurtransferase activity
CR143_RS01850	COG0432	Pfam Uncharacterised protein family UPF0047
CR143_RS01875	COG0438	transferase activity, transferring glycosyl groups
CR143_RS01895	COG2084	Dehydrogenase
CR143_RS01900	COG1758	RNA polymerase activity
CR143_RS01920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CR143_RS01930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CR143_RS01935	COG0247	lactate metabolic process
CR143_RS01935	COG0277	FAD linked oxidase domain protein
CR143_RS01940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CR143_RS01950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CR143_RS01955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CR143_RS01970	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CR143_RS01975	COG0546	phosphoglycolate phosphatase activity
CR143_RS01980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CR143_RS01985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CR143_RS01990	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CR143_RS01995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CR143_RS02000	COG0215	cysteine-tRNA ligase activity
CR143_RS02005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CR143_RS02015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CR143_RS02020	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CR143_RS02030	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CR143_RS02035	COG0047	phosphoribosylformylglycinamidine synthase activity
CR143_RS02045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CR143_RS02050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CR143_RS02055	COG0024	Methionine aminopeptidase
CR143_RS02060	COG1489	DNA binding
CR143_RS02065	COG1058	Belongs to the CinA family
CR143_RS02065	COG1546	Belongs to the CinA family
CR143_RS02070	COG1573	uracil-dna glycosylase
CR143_RS02085	COG0187	DNA topoisomerase II activity
CR143_RS02090	COG0174	glutamine synthetase
CR143_RS02095	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CR143_RS02095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CR143_RS02115	COG0544	peptidyl-prolyl cis-trans isomerase activity
CR143_RS02120	COG0740	serine-type endopeptidase activity
CR143_RS02125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CR143_RS02130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CR143_RS02155	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CR143_RS02175	COG0730	response to heat
CR143_RS02205	COG2095	MarC family integral membrane protein
CR143_RS02225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CR143_RS02240	COG0250	Participates in transcription elongation, termination and antitermination
CR143_RS02245	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CR143_RS02250	COG0081	regulation of translation
CR143_RS02255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CR143_RS02260	COG0222	ribosome binding
CR143_RS02265	COG0085	RNA polymerase activity
CR143_RS02270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CR143_RS02275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CR143_RS02280	COG0049	tRNA binding
CR143_RS02285	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CR143_RS02290	COG0051	transcription antitermination factor activity, RNA binding
CR143_RS02295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CR143_RS02300	COG0088	Forms part of the polypeptide exit tunnel
CR143_RS02305	COG0089	rRNA binding
CR143_RS02310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CR143_RS02315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CR143_RS02320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CR143_RS02325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CR143_RS02330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CR143_RS02335	COG0255	Belongs to the universal ribosomal protein uL29 family
CR143_RS02340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CR143_RS02345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CR143_RS02350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CR143_RS02355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CR143_RS02360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CR143_RS02365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CR143_RS02370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CR143_RS02380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CR143_RS02385	COG0200	Binds to the 23S rRNA
CR143_RS02395	COG0563	adenylate kinase activity
CR143_RS02400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CR143_RS02405	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CR143_RS02410	COG0202	RNA polymerase activity
CR143_RS02415	COG0203	ribosomal protein L17
CR143_RS02420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CR143_RS02425	COG0564	pseudouridine synthase activity
CR143_RS02430	COG0321	lipoyl(octanoyl) transferase activity
CR143_RS02445	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CR143_RS02470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CR143_RS02475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CR143_RS02480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CR143_RS02485	COG0540	Belongs to the ATCase OTCase family
CR143_RS02490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CR143_RS02495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CR143_RS02500	COG0154	amidase activity
CR143_RS02505	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CR143_RS02515	COG1054	Belongs to the UPF0176 family
CR143_RS02520	COG0678	peroxiredoxin activity
CR143_RS02530	COG1217	gtp-binding protein TYPA
CR143_RS02535	COG1741	Belongs to the pirin family
CR143_RS02540	COG2076	Multidrug Resistance protein
CR143_RS02560	COG0741	lytic transglycosylase activity
CR143_RS02565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CR143_RS02570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CR143_RS02580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CR143_RS02590	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CR143_RS02600	COG0681	Belongs to the peptidase S26 family
CR143_RS02605	COG0571	ribonuclease III activity
CR143_RS02610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CR143_RS02620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CR143_RS02630	COG0113	porphobilinogen synthase activity
CR143_RS02635	COG0156	8-amino-7-oxononanoate synthase activity
CR143_RS02645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CR143_RS02650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CR143_RS02655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CR143_RS02655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CR143_RS02660	COG0307	riboflavin synthase, alpha
CR143_RS02670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CR143_RS02675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CR143_RS02680	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CR143_RS02695	COG0416	fatty acid biosynthetic process
CR143_RS02700	COG0776	regulation of translation
CR143_RS02720	COG1612	heme a metabolic process
CR143_RS02725	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CR143_RS02730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CR143_RS02735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CR143_RS02740	COG0460	homoserine dehydrogenase
CR143_RS02745	COG1494	fructose-1,6-bisphosphatase
CR143_RS02750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CR143_RS02760	COG0179	Fumarylacetoacetate (FAA) hydrolase
CR143_RS02765	COG0386	Belongs to the glutathione peroxidase family
CR143_RS02780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CR143_RS02790	COG0343	queuine tRNA-ribosyltransferase activity
CR143_RS02835	COG0438	transferase activity, transferring glycosyl groups
CR143_RS02845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CR143_RS02845	COG0321	lipoyl(octanoyl) transferase activity
CR143_RS02850	COG0084	hydrolase, TatD family'
CR143_RS02860	COG0470	DNA polymerase III
CR143_RS02865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CR143_RS02870	COG1686	Belongs to the peptidase S11 family
CR143_RS02880	COG2951	lytic endotransglycosylase activity
CR143_RS02895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CR143_RS02900	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CR143_RS02910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CR143_RS02915	COG0629	single-stranded DNA binding
CR143_RS02920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CR143_RS02930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CR143_RS02935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CR143_RS02940	COG1862	Preprotein translocase
CR143_RS02950	COG0805	protein transport
CR143_RS02955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CR143_RS02960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CR143_RS02965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CR143_RS02970	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CR143_RS02975	COG1472	Belongs to the glycosyl hydrolase 3 family
CR143_RS02985	COG0018	arginyl-trna synthetase
CR143_RS02990	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CR143_RS02995	COG0316	Belongs to the HesB IscA family
CR143_RS03000	COG0708	Exodeoxyribonuclease III
CR143_RS03005	COG0662	Cupin 2, conserved barrel domain protein
CR143_RS03005	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CR143_RS03015	COG0129	dihydroxy-acid dehydratase activity
CR143_RS03020	COG0525	valine-tRNA ligase activity
CR143_RS03025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CR143_RS03040	COG1396	sequence-specific DNA binding
CR143_RS03045	COG0415	Belongs to the DNA photolyase family
CR143_RS03050	COG1233	COG1233 Phytoene dehydrogenase and related
CR143_RS03060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CR143_RS03070	COG1126	abc transporter atp-binding protein
CR143_RS03075	COG0765	amino acid transport
CR143_RS03080	COG4597	amino acid ABC transporter
CR143_RS03085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR143_RS03090	COG2827	Endonuclease containing a URI domain
CR143_RS03105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CR143_RS03110	COG2204	response regulator
CR143_RS03115	COG5000	phosphorelay sensor kinase activity
CR143_RS03120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CR143_RS03120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CR143_RS03140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CR143_RS03150	COG0148	phosphopyruvate hydratase activity
CR143_RS03160	COG0504	CTP synthase activity
CR143_RS03165	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CR143_RS03170	COG0149	triose-phosphate isomerase activity
CR143_RS03180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CR143_RS03185	COG0512	Glutamine amidotransferase of anthranilate synthase
CR143_RS03185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CR143_RS03190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CR143_RS03200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CR143_RS03205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CR143_RS03210	COG0372	Belongs to the citrate synthase family
CR143_RS03225	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CR143_RS03230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CR143_RS03235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CR143_RS03240	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CR143_RS03245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CR143_RS03250	COG4589	Belongs to the CDS family
CR143_RS03260	COG0233	cytoplasmic translational termination
CR143_RS03265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CR143_RS03270	COG0052	Belongs to the universal ribosomal protein uS2 family
CR143_RS03280	COG1136	(ABC) transporter
CR143_RS03290	COG0442	prolyl-tRNA aminoacylation
CR143_RS03305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CR143_RS03310	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CR143_RS03310	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CR143_RS03315	COG1007	ATP synthesis coupled electron transport
CR143_RS03330	COG0713	ATP synthesis coupled electron transport
CR143_RS03335	COG0839	Belongs to the complex I subunit 6 family
CR143_RS03340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CR143_RS03345	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CR143_RS03350	COG1034	ATP synthesis coupled electron transport
CR143_RS03360	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CR143_RS03365	COG0649	NAD binding
CR143_RS03370	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CR143_RS03375	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CR143_RS03380	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CR143_RS03405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CR143_RS03430	COG2339	peptidase activity
CR143_RS03445	COG5361	Conserved Protein
CR143_RS03460	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CR143_RS03465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CR143_RS03480	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CR143_RS03485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CR143_RS03490	COG0316	Belongs to the HesB IscA family
CR143_RS03495	COG2151	metal-sulfur cluster biosynthetic enzyme
CR143_RS03505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CR143_RS03510	COG0719	Fe-S assembly protein
CR143_RS03515	COG0396	ATPase activity
CR143_RS03520	COG0719	Fe-S assembly protein
CR143_RS03525	COG1104	cysteine desulfurase activity
CR143_RS03535	COG2945	thiolester hydrolase activity
CR143_RS03540	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CR143_RS03545	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CR143_RS03560	COG1530	ribonuclease E activity
CR143_RS03580	COG0439	Biotin carboxylase
CR143_RS03590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CR143_RS03595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CR143_RS03615	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CR143_RS03620	COG0105	UTP biosynthetic process
CR143_RS03625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CR143_RS03630	COG0795	lipopolysaccharide-transporting ATPase activity
CR143_RS03650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CR143_RS03655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CR143_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
CR143_RS03675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CR143_RS03680	COG0360	Binds together with S18 to 16S ribosomal RNA
CR143_RS03685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CR143_RS03690	COG0359	binds to the 23S rRNA
CR143_RS03700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CR143_RS03715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CR143_RS03720	COG1160	GTP binding
CR143_RS03735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CR143_RS03740	COG0519	Catalyzes the synthesis of GMP from XMP
CR143_RS03750	COG0517	IMP dehydrogenase activity
CR143_RS03750	COG0516	GMP reductase activity
CR143_RS03755	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CR143_RS03765	COG1183	phosphatidylcholine synthase activity
CR143_RS03770	COG0688	phosphatidylethanolamine metabolic process
CR143_RS03775	COG0538	isocitrate dehydrogenase activity
CR143_RS03780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CR143_RS03785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CR143_RS03795	COG0572	uridine kinase
CR143_RS03805	COG0625	glutathione transferase activity
CR143_RS03820	COG0463	Glycosyl transferase, family 2
CR143_RS03825	COG0492	ferredoxin-NADP+ reductase activity
CR143_RS03830	COG0633	Ferredoxin
CR143_RS03835	COG4948	Mandelate Racemase Muconate Lactonizing
CR143_RS03850	COG1562	ergosterol biosynthetic process
CR143_RS03870	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CR143_RS03875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CR143_RS03885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CR143_RS03890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CR143_RS03900	COG0513	Belongs to the DEAD box helicase family
CR143_RS03905	COG2862	Uncharacterized protein family, UPF0114
CR143_RS03915	COG2192	nodulation
CR143_RS03945	COG0730	response to heat
CR143_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
CR143_RS03965	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CR143_RS03980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CR143_RS03995	COG0574	Belongs to the PEP-utilizing enzyme family
CR143_RS03995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CR143_RS04005	COG0752	glycyl-tRNA synthetase alpha subunit
CR143_RS04020	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CR143_RS04025	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CR143_RS04025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CR143_RS04030	COG0509	glycine decarboxylation via glycine cleavage system
CR143_RS04035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CR143_RS04045	COG0259	pyridoxamine-phosphate oxidase activity
CR143_RS04050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CR143_RS04060	COG1028	Short-chain dehydrogenase reductase Sdr
CR143_RS04065	COG4336	lyase activity
CR143_RS04075	COG0411	ABC transporter
CR143_RS04095	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CR143_RS04100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CR143_RS04105	COG1984	allophanate hydrolase subunit 2
CR143_RS04110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CR143_RS04125	COG2358	TRAP transporter, solute receptor (TAXI family
CR143_RS04140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CR143_RS04170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CR143_RS04180	COG3411	Ferredoxin
CR143_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
CR143_RS04200	COG0210	DNA helicase
CR143_RS04205	COG0006	proline dipeptidase activity
CR143_RS04210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CR143_RS04215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CR143_RS04220	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CR143_RS04235	COG1181	Belongs to the D-alanine--D-alanine ligase family
CR143_RS04240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CR143_RS04245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CR143_RS04250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CR143_RS04260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CR143_RS04265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CR143_RS04270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CR143_RS04275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CR143_RS04290	COG0275	rRNA processing
CR143_RS04295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CR143_RS04300	COG2001	Belongs to the MraZ family
CR143_RS04310	COG3023	N-Acetylmuramoyl-L-alanine amidase
CR143_RS04315	COG2853	Lipoprotein
CR143_RS04330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CR143_RS04335	COG0358	DNA primase activity
CR143_RS04340	COG1610	YqeY-like protein
CR143_RS04345	COG0505	Belongs to the CarA family
CR143_RS04365	COG0492	ferredoxin-NADP+ reductase activity
CR143_RS04370	COG0436	Aminotransferase
CR143_RS04375	COG0556	nucleotide-excision repair
CR143_RS04380	COG1028	Short-chain dehydrogenase reductase Sdr
CR143_RS04390	COG0322	excinuclease ABC activity
CR143_RS04400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CR143_RS04410	COG0745	RESPONSE REGULATOR receiver
CR143_RS04425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CR143_RS04440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CR143_RS04445	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CR143_RS04450	COG0193	aminoacyl-tRNA hydrolase activity
CR143_RS04460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CR143_RS04460	COG2857	Cytochrome c1
CR143_RS04475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CR143_RS04485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CR143_RS04490	COG0617	tRNA 3'-terminal CCA addition
CR143_RS04505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CR143_RS04515	COG1573	uracil-dna glycosylase
CR143_RS04520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CR143_RS04535	COG1194	a g-specific adenine glycosylase
CR143_RS04550	COG1196	nuclear chromosome segregation
CR143_RS04560	COG0356	it plays a direct role in the translocation of protons across the membrane
CR143_RS04565	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CR143_RS04570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CR143_RS04575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CR143_RS04585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CR143_RS04590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CR143_RS04595	COG0328	RNA-DNA hybrid ribonuclease activity
CR143_RS04605	COG3346	SURF1 family
CR143_RS04615	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CR143_RS04620	COG0109	protoheme IX farnesyltransferase activity
CR143_RS04625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CR143_RS04630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CR143_RS04635	COG0312	modulator of DNA gyrase
CR143_RS04640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CR143_RS04645	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CR143_RS04650	COG0312	modulator of DNA gyrase
CR143_RS04655	COG1132	(ABC) transporter
CR143_RS04660	COG1519	Transferase
CR143_RS04660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CR143_RS04665	COG1663	tetraacyldisaccharide 4'-kinase activity
CR143_RS04690	COG0151	Belongs to the GarS family
CR143_RS04695	COG0590	tRNA wobble adenosine to inosine editing
CR143_RS04700	COG1187	pseudouridine synthase activity
CR143_RS04710	COG0166	Belongs to the GPI family
CR143_RS04720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CR143_RS04725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CR143_RS04730	COG0196	riboflavin kinase activity
CR143_RS04740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CR143_RS04745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CR143_RS04750	COG0459	protein refolding
CR143_RS04755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CR143_RS04765	COG0124	histidyl-tRNA synthetase
CR143_RS04790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CR143_RS04795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CR143_RS04805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CR143_RS04845	COG0508	dehydrogenase complex catalyzes the overall conversion of
CR143_RS04860	COG1088	dTDP-glucose 4,6-dehydratase activity
CR143_RS04910	COG0481	GTPase activity
CR143_RS04915	COG0072	phenylalanine-tRNA ligase activity
CR143_RS04920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CR143_RS04925	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CR143_RS04930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CR143_RS04935	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CR143_RS04940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CR143_RS04970	COG1968	undecaprenyl-diphosphatase activity
CR143_RS04985	COG0517	IMP dehydrogenase activity
CR143_RS04985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CR143_RS04995	COG1137	ATPase activity
CR143_RS05005	COG2079	MmgE PrpD family protein
CR143_RS05025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CR143_RS05030	COG2239	Acts as a magnesium transporter
CR143_RS05035	COG0697	spore germination
CR143_RS05045	COG1666	GTP binding
CR143_RS05070	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CR143_RS05085	COG0697	spore germination
CR143_RS05100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CR143_RS05115	COG1770	oligopeptidase
CR143_RS05120	COG0189	ligase activity
CR143_RS05140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CR143_RS05150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CR143_RS05165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CR143_RS05185	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CR143_RS05190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CR143_RS05195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CR143_RS05200	COG0842	Transport permease protein
CR143_RS05210	COG0745	RESPONSE REGULATOR receiver
CR143_RS05220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CR143_RS05230	COG0573	inorganic phosphate transmembrane transporter activity
CR143_RS05240	COG5002	protein histidine kinase activity
CR143_RS05260	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CR143_RS05270	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CR143_RS05275	COG0594	ribonuclease P activity
CR143_RS05280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CR143_RS05285	COG0706	membrane insertase activity
CR143_RS05290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CR143_RS05300	COG2171	N-acyltransferase activity
CR143_RS05305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CR143_RS05310	COG0123	including yeast histone deacetylase and acetoin utilization protein
CR143_RS05315	COG0101	tRNA pseudouridine synthase activity
CR143_RS05320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CR143_RS05325	COG0242	peptide deformylase activity
CR143_RS05330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CR143_RS05335	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CR143_RS05340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CR143_RS05355	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CR143_RS05360	COG3474	cytochrome
CR143_RS05385	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CR143_RS05390	COG1329	Transcriptional regulator
CR143_RS05430	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CR143_RS05450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CR143_RS05455	COG0165	Argininosuccinate lyase
CR143_RS05460	COG0019	diaminopimelate decarboxylase activity
CR143_RS05470	COG0287	Prephenate dehydrogenase
CR143_RS05475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CR143_RS05480	COG2813	Specifically methylates the guanine in position
CR143_RS05480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CR143_RS05485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CR143_RS05490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CR143_RS05495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CR143_RS05500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CR143_RS05505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CR143_RS05510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CR143_RS05515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CR143_RS05520	COG0799	negative regulation of ribosome biogenesis
CR143_RS05525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CR143_RS05530	COG0793	Belongs to the peptidase S41A family
CR143_RS05535	COG1051	belongs to the nudix hydrolase family
CR143_RS05540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CR143_RS05545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CR143_RS05550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CR143_RS05555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CR143_RS05560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CR143_RS05565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CR143_RS05570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CR143_RS05580	COG0508	dehydrogenase complex catalyzes the overall conversion of
CR143_RS05590	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CR143_RS05595	COG0045	succinate-CoA ligase (ADP-forming) activity
CR143_RS05600	COG0039	L-malate dehydrogenase activity
CR143_RS05615	COG1053	succinate dehydrogenase
CR143_RS05625	COG2009	succinate dehydrogenase
CR143_RS05630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CR143_RS05635	COG0473	3-isopropylmalate dehydrogenase activity
CR143_RS05640	COG0066	3-isopropylmalate dehydratase activity
CR143_RS05645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CR143_RS05650	COG0335	large ribosomal subunit rRNA binding
CR143_RS05655	COG0336	Belongs to the RNA methyltransferase TrmD family
CR143_RS05660	COG0228	four-way junction DNA binding
CR143_RS05665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CR143_RS05670	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CR143_RS05675	COG0552	protein localization to endoplasmic reticulum
CR143_RS05685	COG2084	Dehydrogenase
CR143_RS05700	COG0154	amidase activity
CR143_RS05715	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CR143_RS05720	COG0861	Integral membrane protein TerC family
CR143_RS05730	COG0247	lactate metabolic process
CR143_RS05735	COG0277	FAD linked oxidase domain protein
CR143_RS05740	COG0277	FAD linked oxidase domain protein
CR143_RS05745	COG0436	Aminotransferase
CR143_RS05750	COG1304	FMN binding
CR143_RS05760	COG3088	subunit of a heme lyase
CR143_RS05765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CR143_RS05770	COG1138	Cytochrome C-type biogenesis protein
CR143_RS05775	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CR143_RS05780	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CR143_RS05785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CR143_RS05800	COG2917	probably involved in intracellular septation
CR143_RS05820	COG0670	Belongs to the BI1 family
CR143_RS05825	COG0667	Aldo Keto reductase
CR143_RS05835	COG0137	argininosuccinate synthase activity
CR143_RS05840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CR143_RS05850	COG0181	hydroxymethylbilane synthase activity
CR143_RS05855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CR143_RS05865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CR143_RS05870	COG5508	conserved small protein
CR143_RS05885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CR143_RS05895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CR143_RS05905	COG0138	bifunctional purine biosynthesis protein purh
CR143_RS05910	COG2154	pterin-4-alpha-carbinolamine dehydratase
CR143_RS05930	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CR143_RS05935	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CR143_RS05940	COG1981	membrane
CR143_RS05945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CR143_RS05950	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CR143_RS05955	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CR143_RS05960	COG0424	maF-like protein
CR143_RS05965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CR143_RS05970	COG0237	dephospho-CoA kinase activity
CR143_RS05975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CR143_RS05980	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CR143_RS05995	COG0131	Imidazoleglycerol-phosphate dehydratase
CR143_RS06000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CR143_RS06005	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CR143_RS06010	COG0107	imidazoleglycerol-phosphate synthase activity
CR143_RS06015	COG0140	phosphoribosyl-ATP diphosphatase activity
CR143_RS06035	COG1674	ftsk spoiiie
CR143_RS06040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CR143_RS06045	COG2169	Transcriptional regulator
CR143_RS06045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CR143_RS06050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CR143_RS06055	COG0445	tRNA wobble uridine modification
CR143_RS06060	COG0357	Ribosomal RNA small subunit methyltransferase G
CR143_RS06070	COG1475	DNA binding
CR143_RS06085	COG0495	leucyl-tRNA aminoacylation
CR143_RS06120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CR143_RS06130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CR143_RS06140	COG0484	heat shock protein binding
CR143_RS06145	COG0443	Heat shock 70 kDa protein
CR143_RS06150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CR143_RS06155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CR143_RS06160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CR143_RS06165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CR143_RS06175	COG0280	phosphate acetyltransferase
CR143_RS06175	COG0281	malic enzyme
CR143_RS06180	COG0728	peptidoglycan biosynthetic process
CR143_RS06185	COG0180	Tryptophanyl-tRNA synthetase
CR143_RS06195	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CR143_RS06215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CR143_RS06220	COG1702	phosphate starvation-inducible protein PhoH
CR143_RS06230	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CR143_RS06235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CR143_RS06240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CR143_RS06240	COG2890	protein-(glutamine-N5) methyltransferase activity
CR143_RS06250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CR143_RS06255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CR143_RS06260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CR143_RS06265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CR143_RS06270	COG1185	polyribonucleotide nucleotidyltransferase activity
CR143_RS06275	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CR143_RS06285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CR143_RS06295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CR143_RS06300	COG0756	dUTP diphosphatase activity
CR143_RS06305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CR143_RS06320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CR143_RS06325	COG0268	Binds directly to 16S ribosomal RNA