locus-tag class description FSYMDG_RS00015 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FSYMDG_RS00025 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FSYMDG_RS00030 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FSYMDG_RS00035 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FSYMDG_RS00040 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FSYMDG_RS00050 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FSYMDG_RS00055 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FSYMDG_RS00100 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FSYMDG_RS00140 ENOG4107QN2 dihydrolipoyl dehydrogenase FSYMDG_RS00155 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN FSYMDG_RS00160 ENOG4108V1U phospholipid-binding protein FSYMDG_RS00175 ENOG4105E0A ABC, transporter FSYMDG_RS00180 ENOG4105TVJ transport system, permease FSYMDG_RS00185 ENOG4105DQ5 transport system permease protein FSYMDG_RS00205 ENOG4105WQT MbtH domain protein FSYMDG_RS00225 ENOG4105BZ1 (ABC) transporter FSYMDG_RS00230 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FSYMDG_RS00240 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FSYMDG_RS00360 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FSYMDG_RS00460 ENOG4105EC2 ftsk spoIIIe FSYMDG_RS00475 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FSYMDG_RS00490 ENOG4105ZXU NLP P60 protein FSYMDG_RS00550 ENOG4105EKQ RNA-directed DNA polymerase FSYMDG_RS00645 ENOG4105D5G Transposase FSYMDG_RS00675 ENOG4105C1G acyl-Coa dehydrogenase FSYMDG_RS00680 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS00685 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS00690 ENOG4105XUP Phage derived protein Gp49-like (DUF891) FSYMDG_RS00720 ENOG4105C8M UPF0272 protein FSYMDG_RS00740 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FSYMDG_RS00745 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FSYMDG_RS00760 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FSYMDG_RS00775 ENOG4107QIK phosphoribosylformylglycinamidine synthase FSYMDG_RS00790 ENOG4108N0W Major Facilitator superfamily FSYMDG_RS00800 ENOG4108UIH futalosine nucleosidase FSYMDG_RS00805 ENOG4105E63 Pfam:DUF178 FSYMDG_RS00810 ENOG4105VEQ Cold shock protein FSYMDG_RS00825 ENOG410839H phosphoribosylformylglycinamidine synthase FSYMDG_RS00830 ENOG41082J7 Rhodanese domain protein FSYMDG_RS00845 ENOG4105C75 arginyL-tRNA synthetase FSYMDG_RS00880 ENOG4105HZM Fha domain containing protein FSYMDG_RS00895 ENOG4105CJN penicillin-binding protein FSYMDG_RS00900 ENOG4107TPY serine threonine protein kinase FSYMDG_RS00905 ENOG4105D9P serine threonine protein kinase FSYMDG_RS00915 ENOG4105CEY Amp-dependent synthetase and ligase FSYMDG_RS00920 ENOG4105ZJT Cell division protein CrgA FSYMDG_RS01035 ENOG4105S10 periplasmic binding protein FSYMDG_RS01045 ENOG4105RHY Pfam:UPF0157 FSYMDG_RS01060 ENOG4105MSY salicylate hydroxylase FSYMDG_RS01240 ENOG4108UN4 phage SPO1 DNA polymerase-related protein FSYMDG_RS01255 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FSYMDG_RS01265 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FSYMDG_RS01270 ENOG4105BZN citrate synthase FSYMDG_RS01275 ENOG4105CPC Aldo Keto reductase FSYMDG_RS01315 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FSYMDG_RS01320 ENOG4105GVF (ABC) transporter FSYMDG_RS01325 ENOG4108UZX fmn reductase FSYMDG_RS01365 ENOG4105CXB phosphoribosylaminoimidazole synthetase FSYMDG_RS01385 ENOG4108TAC FSYMDG_RS01400 ENOG4105DWT malate dehydrogenase (quinone) FSYMDG_RS01460 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FSYMDG_RS01495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FSYMDG_RS01500 ENOG4105BZU Histidine kinase FSYMDG_RS01505 ENOG4105CMR udp-glucose 4-epimerase FSYMDG_RS01515 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FSYMDG_RS01540 ENOG4105KDC 50s ribosomal protein l28 FSYMDG_RS01545 ENOG4105W0E 50S ribosomal protein L33 FSYMDG_RS01550 ENOG41082R9 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FSYMDG_RS01555 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FSYMDG_RS01590 ENOG4105EBR Carboxylesterase FSYMDG_RS01635 ENOG4105VTR Integrase FSYMDG_RS01720 ENOG410905P Pyridoxamine 5-phosphate FSYMDG_RS01795 ENOG4105CEY Amp-dependent synthetase and ligase FSYMDG_RS01845 ENOG410834F Transcriptional regulator FSYMDG_RS01850 ENOG4105E8G Major facilitator Superfamily FSYMDG_RS01860 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A FSYMDG_RS01865 ENOG410901E Membrane FSYMDG_RS01870 ENOG4105CIR epoxide hydrolase FSYMDG_RS01875 ENOG4105VG9 Plasmid stabilization system FSYMDG_RS01890 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FSYMDG_RS01900 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSYMDG_RS01905 ENOG4108JQ6 ABC transporter FSYMDG_RS01925 ENOG4105DEN Luciferase family FSYMDG_RS01945 ENOG4105M2Z protein tyrosine serine phosphatase FSYMDG_RS01965 ENOG41062IE glyoxalase bleomycin resistance protein dioxygenase FSYMDG_RS01975 ENOG4106CY5 excisionase FSYMDG_RS01985 ENOG4107T65 Integrase FSYMDG_RS01995 ENOG41073TP transcriptional regulator FSYMDG_RS02035 ENOG4107EEY synthase FSYMDG_RS02045 ENOG4105WCA Ferredoxin FSYMDG_RS02060 ENOG4105DPX Hydrogenase, large subunit FSYMDG_RS02065 ENOG4105E3S small subunit FSYMDG_RS02080 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FSYMDG_RS02120 ENOG4105EDW glycosyl transferase, family 39 FSYMDG_RS02135 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FSYMDG_RS02140 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) FSYMDG_RS02145 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FSYMDG_RS02155 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FSYMDG_RS02295 ENOG4105IDI abc transporter atp-binding protein FSYMDG_RS02300 ENOG4107QJE Chromosome Partitioning Protein FSYMDG_RS02320 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FSYMDG_RS02330 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS02375 ENOG4107QPH glycogen) synthase FSYMDG_RS02380 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FSYMDG_RS02390 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FSYMDG_RS02435 ENOG4105CZS beta-ketoacyl synthase FSYMDG_RS02450 ENOG4108Y5I Cyclase dehydrase FSYMDG_RS02465 ENOG4105KTE polyketide synthesis cyclase FSYMDG_RS02485 ENOG4105GWZ Roadblock lc7 family protein FSYMDG_RS02495 ENOG4105D9P serine threonine protein kinase FSYMDG_RS02515 ENOG4105CJ1 ABC, transporter FSYMDG_RS02525 ENOG4105CI0 Citrate lyase FSYMDG_RS02535 ENOG4105C4X radical SAM domain protein FSYMDG_RS02585 ENOG41080XQ Signal transduction protein with cbs domains FSYMDG_RS02615 ENOG4105BZU Histidine kinase FSYMDG_RS02620 ENOG4105CVA phosphate FSYMDG_RS02625 ENOG41085FC arsR family transcriptional regulator FSYMDG_RS02640 ENOG4105HS2 Arsenate reductase FSYMDG_RS02645 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS02680 ENOG4105VMP Transcriptional regulator FSYMDG_RS02700 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FSYMDG_RS02710 ENOG4108ZXC Two component transcriptional regulator, luxr family FSYMDG_RS02735 ENOG4108MMM RNA Polymerase FSYMDG_RS02755 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS02760 ENOG4105XUP Phage derived protein Gp49-like (DUF891) FSYMDG_RS02770 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS02790 ENOG4105CB5 ATP-dependent DNA helicase recG FSYMDG_RS02835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FSYMDG_RS02840 ENOG4105BZU Histidine kinase FSYMDG_RS02845 ENOG4105CBG Sulfatase FSYMDG_RS02850 ENOG4105CPC Aldo Keto reductase FSYMDG_RS02865 ENOG4105VEQ Cold shock protein FSYMDG_RS02870 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FSYMDG_RS02875 ENOG4105CFH Aspartokinase FSYMDG_RS02900 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FSYMDG_RS02905 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FSYMDG_RS02980 ENOG4105MS9 Resuscitation-promoting factor FSYMDG_RS03000 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FSYMDG_RS03015 ENOG4105EYF MMPL domain protein FSYMDG_RS03020 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FSYMDG_RS03025 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FSYMDG_RS03030 ENOG4105KNI merR family transcriptional Regulator FSYMDG_RS03035 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FSYMDG_RS03040 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FSYMDG_RS03045 ENOG4105CFG Acts as a chaperone (By similarity) FSYMDG_RS03055 ENOG4105DF6 Fe-S oxidoreductase FSYMDG_RS03060 ENOG4105CRK lysyL-tRNA synthetase FSYMDG_RS03075 ENOG4105DHP deoxycytidine triphosphate deaminase FSYMDG_RS03100 ENOG4105CHR reductase FSYMDG_RS03120 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FSYMDG_RS03165 ENOG4107QUT magnesium and cobalt transport protein CorA FSYMDG_RS03215 ENOG4105C6Y Udp-glucose 6-dehydrogenase FSYMDG_RS03290 ENOG4105DQF Hydrolase FSYMDG_RS03295 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase FSYMDG_RS03300 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FSYMDG_RS03305 ENOG4105EUJ GTP cyclohydrolase i FSYMDG_RS03315 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FSYMDG_RS03330 ENOG4105F0N pyrophosphate phospho-hydrolase FSYMDG_RS03345 ENOG4108KXV response regulator FSYMDG_RS03355 ENOG4105MA4 psp1 domain protein FSYMDG_RS03425 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FSYMDG_RS03455 ENOG4105C3Q Glycosyl transferase, family 2 FSYMDG_RS03465 ENOG4107R13 MMPL domain protein FSYMDG_RS03475 ENOG4105C5F glutamine synthetase FSYMDG_RS03515 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FSYMDG_RS03530 ENOG4105BZU Histidine kinase FSYMDG_RS03535 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FSYMDG_RS03560 ENOG4105BZP glycoside hydrolase 15-related FSYMDG_RS03605 ENOG4105F8V Hydrolase, tatD family FSYMDG_RS03610 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FSYMDG_RS03625 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FSYMDG_RS03630 ENOG4105C5H ABC transporter FSYMDG_RS03645 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FSYMDG_RS03650 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FSYMDG_RS03655 ENOG4105KK4 UPF0060 membrane protein FSYMDG_RS03660 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FSYMDG_RS03665 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FSYMDG_RS03700 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FSYMDG_RS03780 ENOG4105BZU Histidine kinase FSYMDG_RS03795 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FSYMDG_RS03805 ENOG4105T1M mycothiol conjugate amidase mca FSYMDG_RS03820 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FSYMDG_RS03830 ENOG4105C8T Leucyl-tRNA synthetase FSYMDG_RS03840 ENOG4105C7Z Conserved Protein FSYMDG_RS03855 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) FSYMDG_RS03860 ENOG4108IAB Phoh family FSYMDG_RS03865 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FSYMDG_RS03875 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase FSYMDG_RS03930 ENOG4105C9Q fumarate hydratase class II FSYMDG_RS03955 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FSYMDG_RS03960 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FSYMDG_RS04000 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FSYMDG_RS04005 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FSYMDG_RS04020 ENOG4107T8Q Glycosyl transferase (Group 1 FSYMDG_RS04035 ENOG4108I69 Glycosyl transferases group 1 FSYMDG_RS04060 ENOG4105C3G gtp-binding protein FSYMDG_RS04070 ENOG410842T Pterin carbinolamine dehydratase FSYMDG_RS04075 ENOG4105M6F mutator MutT protein FSYMDG_RS04080 ENOG4105CI3 gtp-binding protein typa FSYMDG_RS04105 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) FSYMDG_RS04125 ENOG4108Z4U Ferredoxin FSYMDG_RS04140 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FSYMDG_RS04145 ENOG4107R4C succinyl-diaminopimelate desuccinylase FSYMDG_RS04155 ENOG4105EEI dihydropteroate synthase FSYMDG_RS04165 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FSYMDG_RS04180 ENOG4105DU6 RNA polymerase FSYMDG_RS04190 ENOG4105C0H protease FSYMDG_RS04205 ENOG41067TZ transcriptional regulator, MarR family FSYMDG_RS04210 ENOG4105DB7 PHP domain protein FSYMDG_RS04215 ENOG4105DGI Alkaline phosphatase FSYMDG_RS04220 ENOG4107TE5 Lipid kinase FSYMDG_RS04235 ENOG4105C26 Dehydrogenase FSYMDG_RS04245 ENOG41083YR Protein CrcB homolog FSYMDG_RS04250 ENOG4105KJJ Uncharacterized ACR, COG1993 FSYMDG_RS04255 ENOG41083TI Protein CrcB homolog FSYMDG_RS04315 ENOG4105C1G acyl-Coa dehydrogenase FSYMDG_RS04325 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A FSYMDG_RS04335 ENOG4105CJW magnesium transporter FSYMDG_RS04375 ENOG4107UAX integral membrane protein FSYMDG_RS04420 ENOG4105FDF Could be involved in DNA repair (By similarity) FSYMDG_RS04440 ENOG4105C4R Atp-dependent dna helicase FSYMDG_RS04465 ENOG4105C31 Tryptophanyl-tRNA synthetase FSYMDG_RS04510 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FSYMDG_RS04530 ENOG4106A3M Cytochrome p-450 FSYMDG_RS04535 ENOG4106A3M Cytochrome p-450 FSYMDG_RS04585 ENOG4105DJZ UPF0182 protein FSYMDG_RS04595 ENOG4107T65 Integrase FSYMDG_RS04680 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FSYMDG_RS04685 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FSYMDG_RS04690 ENOG4105C26 Dehydrogenase FSYMDG_RS04710 ENOG4107TK4 histidinol-phosphate phosphatase FSYMDG_RS04720 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FSYMDG_RS04735 ENOG4105EMN RNA polymerase sigma factor FSYMDG_RS04740 ENOG4105WMN AntiSigma factor FSYMDG_RS04760 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FSYMDG_RS04770 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FSYMDG_RS04775 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FSYMDG_RS04780 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FSYMDG_RS04795 ENOG4105CBD Diacylglycerol kinase FSYMDG_RS04815 ENOG4108VEQ Superoxide dismutase FSYMDG_RS04825 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FSYMDG_RS04840 ENOG4105CB2 alcohol dehydrogenase FSYMDG_RS04845 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FSYMDG_RS04855 ENOG4107SCA Formamidase (EC 3.5.1.49) FSYMDG_RS04860 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS04870 ENOG4105E33 succinate dehydrogenase FSYMDG_RS04895 ENOG4108DT4 serine threonine protein kinase FSYMDG_RS04915 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FSYMDG_RS04920 ENOG4108R3E Dna-3-methyladenine glycosylase i FSYMDG_RS04930 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FSYMDG_RS04935 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FSYMDG_RS04940 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain FSYMDG_RS04960 ENOG4105D5P Methylmalonyl-coA mutase FSYMDG_RS04980 ENOG4105C9M aspartyl-trna synthetase FSYMDG_RS04985 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) FSYMDG_RS04990 ENOG4107RM1 amidohydrolase FSYMDG_RS04995 ENOG4107R13 MMPL domain protein FSYMDG_RS05020 ENOG4108JIK carboxylase FSYMDG_RS05025 ENOG4105D8K carboxyl transferase FSYMDG_RS05060 ENOG4107TB5 TRANSCRIPTIONal FSYMDG_RS05065 ENOG4107TB5 TRANSCRIPTIONal FSYMDG_RS05070 ENOG4107V9E glucose-1-phosphate thymidylyltransferase FSYMDG_RS05080 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FSYMDG_RS05085 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FSYMDG_RS05100 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FSYMDG_RS05125 ENOG4108TJN glycosyl transferase group 1 FSYMDG_RS05145 ENOG4105MFV ABC-2 type transporter FSYMDG_RS05175 ENOG4105CKK Glycosyl transferase, family 2 FSYMDG_RS05210 ENOG4107R3N Filamentation induced by cAMP protein fic FSYMDG_RS05220 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FSYMDG_RS05230 ENOG4105E2K Glycosyl transferase (Group 1 FSYMDG_RS05245 ENOG4105C7I Dehydrogenase FSYMDG_RS05260 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) FSYMDG_RS05270 ENOG4108IG5 Transcriptional regulator FSYMDG_RS05280 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FSYMDG_RS05285 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FSYMDG_RS05320 ENOG4107QKV phosphomannomutase FSYMDG_RS05325 ENOG4105W49 UPF0434 protein FSYMDG_RS05335 ENOG4105BZ4 penicillin-binding protein FSYMDG_RS05350 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FSYMDG_RS05370 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FSYMDG_RS05375 ENOG4108WQ6 secreted protein FSYMDG_RS05395 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea FSYMDG_RS05400 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS05410 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FSYMDG_RS05460 ENOG4105C26 Dehydrogenase FSYMDG_RS05505 ENOG4105D6Z AFG1 family ATPase FSYMDG_RS05530 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FSYMDG_RS05555 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FSYMDG_RS05580 ENOG4105CAK Cell division ATP-binding protein ftsE FSYMDG_RS05590 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FSYMDG_RS05600 ENOG4105W1N transcriptional regulator FSYMDG_RS05605 ENOG4108YIQ Alpha beta hydrolase FSYMDG_RS05625 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FSYMDG_RS05635 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FSYMDG_RS05645 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FSYMDG_RS05675 ENOG4105EYF MMPL domain protein FSYMDG_RS05680 ENOG4105U5Y Transcriptional regulator FSYMDG_RS05690 ENOG4108W6C Dehydrogenase FSYMDG_RS05695 ENOG4105FE1 phytoene synthase FSYMDG_RS05715 ENOG4105EWU Squalene--hopene cyclase FSYMDG_RS05785 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FSYMDG_RS05815 ENOG4105CQM Urea amidohydrolase subunit alpha FSYMDG_RS05820 ENOG4105KI2 Urea amidohydrolase subunit beta FSYMDG_RS05825 ENOG4108YZ9 Urea amidohydrolase subunit gamma FSYMDG_RS05830 ENOG4105CPN adenine deaminase FSYMDG_RS05855 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FSYMDG_RS05890 ENOG4105CB5 ATP-dependent DNA helicase recG FSYMDG_RS05915 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) FSYMDG_RS05925 ENOG41081F0 Precorrin-8x methylmutase FSYMDG_RS05930 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase FSYMDG_RS05950 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FSYMDG_RS05960 ENOG4105CYW agmatinase FSYMDG_RS05980 ENOG4108IV0 ABC, transporter FSYMDG_RS05985 ENOG4105C0Z ABC transporter FSYMDG_RS06045 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FSYMDG_RS06075 ENOG4108RQ5 Beta-lactamase domain-containing protein FSYMDG_RS06080 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FSYMDG_RS06085 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FSYMDG_RS06195 ENOG4105CZE histidine utilization repressor FSYMDG_RS06235 ENOG4105E4C Lytic transglycosylase catalytic FSYMDG_RS06255 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FSYMDG_RS06350 ENOG4108V06 Glutathione peroxidase FSYMDG_RS06460 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FSYMDG_RS06470 ENOG4108J5G 6-phosphogluconate dehydrogenase FSYMDG_RS06485 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FSYMDG_RS06490 ENOG4105CC9 acyl-Coa dehydrogenase FSYMDG_RS06495 ENOG4105D2B acyl-CoA dehydrogenase FSYMDG_RS06525 ENOG4105IDI abc transporter atp-binding protein FSYMDG_RS06540 ENOG4105DEN Luciferase family FSYMDG_RS06560 ENOG4105C4M (Ubiquinol oxidase) subunit I FSYMDG_RS06565 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FSYMDG_RS06570 ENOG4108JJ9 ABC, transporter FSYMDG_RS06610 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FSYMDG_RS06730 ENOG4105C57 major facilitator superfamily FSYMDG_RS06815 ENOG4105EC2 ftsk spoIIIe FSYMDG_RS06840 ENOG4105WCJ ec 1.1.1.193 FSYMDG_RS06850 ENOG4105C32 Amino acid ABC transporter (Permease) FSYMDG_RS06855 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FSYMDG_RS06860 ENOG4105C0Z ABC transporter FSYMDG_RS06865 ENOG4108IV0 ABC, transporter FSYMDG_RS06870 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FSYMDG_RS06930 ENOG4105CCU oxidase (Subunit III) FSYMDG_RS06940 ENOG4105CHR reductase FSYMDG_RS06965 ENOG4105BZW Glycerate kinase FSYMDG_RS06970 ENOG4108VQR secreted hydrolase FSYMDG_RS06980 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FSYMDG_RS07005 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FSYMDG_RS07025 ENOG4108ZJ4 polysaccharide deacetylase FSYMDG_RS07030 ENOG4105C26 Dehydrogenase FSYMDG_RS07035 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS07040 ENOG4105C37 (CBS) domain FSYMDG_RS07060 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FSYMDG_RS07075 ENOG4105EUB pirin domain protein FSYMDG_RS07080 ENOG4105BZU Histidine kinase FSYMDG_RS07085 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FSYMDG_RS07090 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FSYMDG_RS07115 ENOG4105C9U ATP-dependent DNA helicase RecQ FSYMDG_RS07125 ENOG4105D29 Helix-turn-helix type 11 domain protein FSYMDG_RS07175 ENOG4105DEI Mannitol dehydrogenase FSYMDG_RS07245 ENOG4105CG3 alpha amylase, catalytic region FSYMDG_RS07260 ENOG4105D8X mechanosensitive ion channel FSYMDG_RS07265 ENOG4105ETX regulatoR FSYMDG_RS07330 ENOG4108YZG isomerase FSYMDG_RS07375 ENOG4105CJ1 ABC, transporter FSYMDG_RS07390 ENOG4105CGK Exodeoxyribonuclease III FSYMDG_RS07420 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FSYMDG_RS07425 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FSYMDG_RS07430 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FSYMDG_RS07435 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FSYMDG_RS07440 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FSYMDG_RS07445 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FSYMDG_RS07450 ENOG4105DFF Rod shape-determining protein mreb FSYMDG_RS07465 ENOG4105CJN penicillin-binding protein FSYMDG_RS07470 ENOG4105CNI cell division protein FtsW FSYMDG_RS07485 ENOG4105C03 ribonuclease FSYMDG_RS07495 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FSYMDG_RS07500 ENOG4105K46 50S ribosomal protein l27 FSYMDG_RS07505 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FSYMDG_RS07510 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FSYMDG_RS07525 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FSYMDG_RS07545 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) FSYMDG_RS07550 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) FSYMDG_RS07560 ENOG4106KE4 Dehydrogenase FSYMDG_RS07565 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FSYMDG_RS07585 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FSYMDG_RS07595 ENOG4108ZM9 phosphoglycerate mutase FSYMDG_RS07645 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FSYMDG_RS07650 ENOG4105ETX regulatoR FSYMDG_RS07675 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FSYMDG_RS07680 ENOG4108FN7 Aldo keto reductase FSYMDG_RS07685 ENOG4106NZI LysR family Transcriptional regulator FSYMDG_RS07695 ENOG41081E8 Alpha beta hydrolase FSYMDG_RS07700 ENOG41067TZ transcriptional regulator, MarR family FSYMDG_RS07705 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase FSYMDG_RS07710 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FSYMDG_RS07725 ENOG4105C2J ABC transporter FSYMDG_RS07730 ENOG4105CNN ABC, transporter FSYMDG_RS07790 ENOG4105MWK D-amino acid dehydrogenase, small subunit FSYMDG_RS07795 ENOG4105CMD Transcriptional regulator, GntR family FSYMDG_RS07825 ENOG4108RAV Conserved protein FSYMDG_RS07840 ENOG4108YYC ycei family FSYMDG_RS07850 ENOG4105KQC Competence protein FSYMDG_RS07870 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FSYMDG_RS07875 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FSYMDG_RS07890 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FSYMDG_RS07895 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FSYMDG_RS07910 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FSYMDG_RS07925 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FSYMDG_RS07950 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FSYMDG_RS07955 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FSYMDG_RS07965 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FSYMDG_RS07990 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FSYMDG_RS08010 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FSYMDG_RS08015 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FSYMDG_RS08020 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FSYMDG_RS08025 ENOG4108U4N (sortase) family FSYMDG_RS08095 ENOG4105MP0 transposase FSYMDG_RS08100 ENOG4105EKQ RNA-directed DNA polymerase FSYMDG_RS08110 ENOG4105EKQ RNA-directed DNA polymerase FSYMDG_RS08115 ENOG4105EKQ RNA-directed DNA polymerase FSYMDG_RS08120 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FSYMDG_RS08135 ENOG4106WTF Glycosyl transferase, family 2 FSYMDG_RS08140 ENOG4108TMJ glycosyl transferase FSYMDG_RS08195 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FSYMDG_RS08205 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FSYMDG_RS08220 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FSYMDG_RS08235 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FSYMDG_RS08240 ENOG4107QQG Dehydrogenase FSYMDG_RS08260 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FSYMDG_RS08265 ENOG4105BZA Phosphoglycerate kinase FSYMDG_RS08275 ENOG4108J59 Extracellular solute-binding protein, family 5 FSYMDG_RS08295 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) FSYMDG_RS08310 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FSYMDG_RS08315 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FSYMDG_RS08320 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FSYMDG_RS08350 ENOG4105JRK feS assembly protein SufD FSYMDG_RS08360 ENOG4105C3K feS assembly ATPase SufC FSYMDG_RS08365 ENOG4105C9B Cysteine desulfurase FSYMDG_RS08370 ENOG4108UNV SUF system FeS assembly protein, NifU family FSYMDG_RS08385 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FSYMDG_RS08430 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FSYMDG_RS08450 ENOG4105C1G acyl-Coa dehydrogenase FSYMDG_RS08455 ENOG4105DEF Extracellular solute-binding protein, family 5 FSYMDG_RS08510 ENOG4105C5H ABC transporter FSYMDG_RS08535 ENOG4105BZ1 (ABC) transporter FSYMDG_RS08575 ENOG4105D5U fad dependent oxidoreductase FSYMDG_RS08580 ENOG4105BZP glycoside hydrolase 15-related FSYMDG_RS08605 ENOG4107S91 Sodium hydrogen exchanger FSYMDG_RS08640 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FSYMDG_RS08660 ENOG4108MJN Glycosyl Transferase FSYMDG_RS08670 ENOG4105CQB FAD linked oxidase domain protein FSYMDG_RS08675 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FSYMDG_RS08700 ENOG4107UBC ErfK ybiS ycfS ynhG family protein FSYMDG_RS08715 ENOG4105C5X domain protein FSYMDG_RS08740 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FSYMDG_RS08755 ENOG4105CAT Cytidine monophosphate kinase FSYMDG_RS08765 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FSYMDG_RS08795 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FSYMDG_RS08805 ENOG4108Z0R Transferase FSYMDG_RS08820 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FSYMDG_RS08835 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FSYMDG_RS08840 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FSYMDG_RS08865 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FSYMDG_RS08870 ENOG4105CHU acetyl-coa acetyltransferase FSYMDG_RS08895 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FSYMDG_RS08900 ENOG4105C1Q protoporphyrinogen oxidase FSYMDG_RS08950 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS08985 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo FSYMDG_RS08990 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FSYMDG_RS09025 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FSYMDG_RS09035 ENOG4105E2Y ABC, transporter FSYMDG_RS09040 ENOG4105CPC Aldo Keto reductase FSYMDG_RS09050 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FSYMDG_RS09070 ENOG4105EPH radical SAM domain protein FSYMDG_RS09100 ENOG4105FS7 Transcriptional regulator FSYMDG_RS09130 ENOG4105E0A ABC, transporter FSYMDG_RS09170 ENOG4107T8P acyl-Coa dehydrogenase FSYMDG_RS09190 ENOG4105C26 Dehydrogenase FSYMDG_RS09200 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FSYMDG_RS09235 ENOG4105CZN Potassium uptake protein FSYMDG_RS09265 ENOG4108YZG isomerase FSYMDG_RS09285 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FSYMDG_RS09335 ENOG4108IV0 ABC, transporter FSYMDG_RS09340 ENOG4105C0Z ABC transporter FSYMDG_RS09350 ENOG4105E9K Isocitrate dehydrogenase FSYMDG_RS09360 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSYMDG_RS09370 ENOG4105DEN Luciferase family FSYMDG_RS09380 ENOG4105DEF Extracellular solute-binding protein, family 5 FSYMDG_RS09455 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FSYMDG_RS09470 ENOG4106YKD Cytochrome p-450 FSYMDG_RS09530 ENOG4105CBC glutamate synthase FSYMDG_RS09630 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FSYMDG_RS09660 ENOG4108JQ1 Dehydrogenase FSYMDG_RS09735 ENOG410905P Pyridoxamine 5-phosphate FSYMDG_RS09740 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FSYMDG_RS09750 ENOG4108Q50 Histidine kinase FSYMDG_RS09775 ENOG4105CAY ferredoxin--nadp reductase FSYMDG_RS09780 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS09785 ENOG4105CEY Amp-dependent synthetase and ligase FSYMDG_RS09805 ENOG4108IPT Naphthoate synthase FSYMDG_RS09810 ENOG4105CEY Amp-dependent synthetase and ligase FSYMDG_RS09820 ENOG410900P UPF0336 protein FSYMDG_RS09825 ENOG4105D2B acyl-CoA dehydrogenase FSYMDG_RS09830 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FSYMDG_RS09835 ENOG4107YCY Transcriptional regulator FSYMDG_RS09840 ENOG4105C1G acyl-Coa dehydrogenase FSYMDG_RS09850 ENOG4105CHR reductase FSYMDG_RS09855 ENOG4105F2C Acetyl-CoA acetyltransferase FSYMDG_RS09860 ENOG4105CYC Transferase FSYMDG_RS09865 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FSYMDG_RS09875 ENOG41060WC Enoyl-CoA hydratase FSYMDG_RS09900 ENOG4108IPT Naphthoate synthase FSYMDG_RS09915 ENOG4107Z7P Ferredoxin FSYMDG_RS09950 ENOG4108JNI Alpha beta hydrolase FSYMDG_RS09955 ENOG4105FUY alpha subunit FSYMDG_RS09965 ENOG41090TK Short-chain dehydrogenase reductase Sdr FSYMDG_RS09970 ENOG4105IKQ hydratase FSYMDG_RS09975 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) FSYMDG_RS09985 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FSYMDG_RS09990 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS09995 ENOG4105C1G acyl-Coa dehydrogenase FSYMDG_RS10025 ENOG4108UKI Enoyl-CoA hydratase FSYMDG_RS10130 ENOG41086KC Transcriptional regulator FSYMDG_RS10155 ENOG4105MXW flavin reductase domain protein, FMN-binding FSYMDG_RS10165 ENOG4105CHU acetyl-coa acetyltransferase FSYMDG_RS10185 ENOG4107QX3 carboxylase FSYMDG_RS10215 ENOG4108R86 Transcriptional regulator FSYMDG_RS10260 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FSYMDG_RS10325 ENOG4105C0R drug resistance transporter emrb qaca subfamily FSYMDG_RS10355 ENOG4105EYF MMPL domain protein FSYMDG_RS10360 ENOG4107XI7 Tetr family transcriptional regulator FSYMDG_RS10365 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FSYMDG_RS10370 ENOG4105E39 Enoyl-CoA hydratase FSYMDG_RS10385 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FSYMDG_RS10395 ENOG4105D9G High-affinity FSYMDG_RS10440 ENOG4105DYW oxidoreductase FSYMDG_RS10475 ENOG4105BZU Histidine kinase FSYMDG_RS10495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FSYMDG_RS10500 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FSYMDG_RS10515 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FSYMDG_RS10520 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FSYMDG_RS10545 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FSYMDG_RS10555 ENOG4108RVA ribokinase FSYMDG_RS10595 ENOG4108UTW Plays a role in the regulation of phosphate uptake FSYMDG_RS10610 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FSYMDG_RS10615 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FSYMDG_RS10620 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FSYMDG_RS10625 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FSYMDG_RS10635 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FSYMDG_RS10640 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FSYMDG_RS10645 ENOG4105CHW UPF0052 protein FSYMDG_RS10650 ENOG4105CIE May be required for sporulation (By similarity) FSYMDG_RS10655 ENOG4107QM5 aconitate hydratase FSYMDG_RS10665 ENOG4105K4H Nlp p60 protein FSYMDG_RS10680 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FSYMDG_RS10720 ENOG4105EC2 ftsk spoIIIe FSYMDG_RS10750 ENOG4105KRM Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FSYMDG_RS10795 ENOG41080HT Transcriptional regulator, arsr family FSYMDG_RS10820 ENOG4105D13 transposase FSYMDG_RS10845 ENOG4106A3M Cytochrome p-450 FSYMDG_RS10860 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FSYMDG_RS10865 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FSYMDG_RS10870 ENOG4105E6M Sulphatase-modifying factor protein FSYMDG_RS10905 ENOG41081K0 peptidylprolyl cis-trans isomerase FSYMDG_RS10910 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) FSYMDG_RS10920 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FSYMDG_RS10925 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) FSYMDG_RS10935 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) FSYMDG_RS10945 ENOG4105E5F proteasome FSYMDG_RS10950 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) FSYMDG_RS10975 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FSYMDG_RS10980 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FSYMDG_RS11030 ENOG4105EW9 transcriptional regulator AsnC family FSYMDG_RS11080 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FSYMDG_RS11150 ENOG4105C7H Helicase, RecD TraA family FSYMDG_RS11155 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FSYMDG_RS11170 ENOG4105C8N cysteinyl-tRNA synthetase FSYMDG_RS11185 ENOG4105C3R Methionine synthase FSYMDG_RS11215 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FSYMDG_RS11220 ENOG4105F27 Major Facilitator FSYMDG_RS11235 ENOG4105KVH Transcriptional regulator FSYMDG_RS11240 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FSYMDG_RS11245 ENOG4108JPZ Monovalent cation H antiporter subunit D FSYMDG_RS11255 ENOG4107TDF Formate hydrogenlyase subunit 4 FSYMDG_RS11265 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FSYMDG_RS11290 ENOG4105D13 transposase FSYMDG_RS11335 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FSYMDG_RS11340 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FSYMDG_RS11355 ENOG4105CTK cobaltochelatase, cobn subunit FSYMDG_RS11370 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS11420 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FSYMDG_RS11430 ENOG4105C1B dTDP-glucose 4-6-dehydratase FSYMDG_RS11435 ENOG4105C22 threonyL-tRNA synthetase FSYMDG_RS11465 ENOG4105C57 major facilitator superfamily FSYMDG_RS11475 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS11490 ENOG4105D8K carboxyl transferase FSYMDG_RS11495 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FSYMDG_RS11520 ENOG4105CZS beta-ketoacyl synthase FSYMDG_RS11535 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FSYMDG_RS11540 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FSYMDG_RS11555 ENOG4105E4R Precorrin-3B C17-methyltransferase FSYMDG_RS11560 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FSYMDG_RS11570 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS11625 ENOG4105CPQ Dehydrogenase FSYMDG_RS11635 ENOG4105HFS 5'-3' exonuclease FSYMDG_RS11645 ENOG4105CI2 imidazolone-5-propionate hydrolase FSYMDG_RS11670 ENOG4105Q70 FSYMDG_RS11675 ENOG4105E0X reductase FSYMDG_RS11680 ENOG4105CEY Amp-dependent synthetase and ligase FSYMDG_RS11685 ENOG410908R Methenyltetrahydrofolate cyclohydrolase FSYMDG_RS11690 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FSYMDG_RS11695 ENOG4105BZU Histidine kinase FSYMDG_RS11700 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FSYMDG_RS11705 ENOG4105Y3U Transglycosylase-associated protein FSYMDG_RS11735 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FSYMDG_RS11780 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FSYMDG_RS11795 ENOG4108Z4X TRANSCRIPTIONal FSYMDG_RS11850 ENOG4105CJ1 ABC, transporter FSYMDG_RS11855 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS11860 ENOG4105BZU Histidine kinase FSYMDG_RS11870 ENOG4105VPX protein, conserved in bacteria FSYMDG_RS11980 ENOG4105VEQ Cold shock protein FSYMDG_RS12125 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSYMDG_RS12135 ENOG4105DEF Extracellular solute-binding protein, family 5 FSYMDG_RS12155 ENOG4105CQS hydrogenase expression formation protein HypD FSYMDG_RS12160 ENOG41082MF Hydrogenase assembly chaperone hypC hupF FSYMDG_RS12165 ENOG4105C45 hydrogenase expression formation protein (HypE) FSYMDG_RS12170 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FSYMDG_RS12195 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FSYMDG_RS12200 ENOG4107RSS Hydrogenase accessory protein HypB FSYMDG_RS12230 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FSYMDG_RS12235 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FSYMDG_RS12305 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FSYMDG_RS12310 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FSYMDG_RS12315 ENOG4105CIH Imidazole acetol-phosphate transaminase FSYMDG_RS12320 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FSYMDG_RS12345 ENOG41084HI prevent-host-death family FSYMDG_RS12350 ENOG4105KRQ Addiction module toxin, Txe YoeB family FSYMDG_RS12430 ENOG4107ZED Uncharacterised protein family UPF0047 FSYMDG_RS12435 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FSYMDG_RS12460 ENOG4105K4P CoA-binding domain protein FSYMDG_RS12470 ENOG4105BZU Histidine kinase FSYMDG_RS12475 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FSYMDG_RS12520 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FSYMDG_RS12525 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FSYMDG_RS12535 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FSYMDG_RS12540 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FSYMDG_RS12555 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FSYMDG_RS12560 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FSYMDG_RS12565 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FSYMDG_RS12575 ENOG4105CDY transcriptional regulatory protein FSYMDG_RS12580 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FSYMDG_RS12585 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FSYMDG_RS12600 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase FSYMDG_RS12630 ENOG4105KF0 sporulation and cell division protein, SsgA FSYMDG_RS12635 ENOG4105CRQ synthase (Component I) FSYMDG_RS12660 ENOG4108RU2 n-acetylmuramoyl-l-alanine amidase FSYMDG_RS12715 ENOG4105F95 Monooxygenase FSYMDG_RS12745 ENOG4105C0R drug resistance transporter emrb qaca subfamily FSYMDG_RS12765 ENOG4108RXW HAD-superfamily subfamily IB hydrolase FSYMDG_RS12790 ENOG4105E5G Alpha beta hydrolase fold FSYMDG_RS12805 ENOG4107U9B transcriptional regulator FSYMDG_RS12820 ENOG41065KQ synthase FSYMDG_RS12865 ENOG4105EA8 2-Nitropropane dioxygenase FSYMDG_RS12910 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FSYMDG_RS12915 ENOG4105CIK Amidinotransferase FSYMDG_RS13015 ENOG4107R9S Malate synthase FSYMDG_RS13080 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FSYMDG_RS13095 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FSYMDG_RS13100 ENOG4105C10 Electron transfer flavoprotein FSYMDG_RS13105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FSYMDG_RS13120 ENOG4105XDV FSYMDG_RS13130 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FSYMDG_RS13150 ENOG4108IV0 ABC, transporter FSYMDG_RS13155 ENOG4105C0Z ABC transporter FSYMDG_RS13255 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FSYMDG_RS13295 ENOG4105CR4 methylisocitrate lyase FSYMDG_RS13315 ENOG4107R3R Cytochrome o ubiquinol oxidase subunit III FSYMDG_RS13325 ENOG4105CHR reductase FSYMDG_RS13330 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FSYMDG_RS13335 ENOG4105DZS Phenylacetate-CoA ligase FSYMDG_RS13340 ENOG4106A3M Cytochrome p-450 FSYMDG_RS13365 ENOG4105C26 Dehydrogenase FSYMDG_RS13380 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS13445 ENOG4105BZM domain protein FSYMDG_RS13460 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS13540 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FSYMDG_RS13555 ENOG4105DEF Extracellular solute-binding protein, family 5 FSYMDG_RS13560 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FSYMDG_RS13575 ENOG4108JQ7 (ABC) transporter FSYMDG_RS13670 ENOG4105CZS beta-ketoacyl synthase FSYMDG_RS13695 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FSYMDG_RS13700 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FSYMDG_RS13705 ENOG4105D8K carboxyl transferase FSYMDG_RS13715 ENOG4105C7H Helicase, RecD TraA family FSYMDG_RS13745 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS13800 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB FSYMDG_RS13810 ENOG4105R88 May protect the nitrogenase Fe-Mo protein from oxidative damage (By similarity) FSYMDG_RS13820 ENOG4108VQE nitrogen fixation protein FSYMDG_RS13830 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN FSYMDG_RS13835 ENOG4105D0B Nitrogenase protein alpha chain FSYMDG_RS13840 ENOG4105CY9 nitrogenase molybdenum-iron protein beta chain FSYMDG_RS13850 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) FSYMDG_RS13855 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FSYMDG_RS13860 ENOG4105DQU oxidoreductase, subunit beta FSYMDG_RS13865 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FSYMDG_RS13885 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FSYMDG_RS13895 ENOG4105CBC glutamate synthase FSYMDG_RS13900 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FSYMDG_RS13905 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FSYMDG_RS13910 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FSYMDG_RS13915 ENOG4105DK0 Indole-3-glycerol phosphate synthase FSYMDG_RS13925 ENOG4105CRQ synthase (Component I) FSYMDG_RS13930 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FSYMDG_RS13940 ENOG4107RP9 extracellular solute-binding protein, family 3 FSYMDG_RS13970 ENOG4105BZ1 (ABC) transporter FSYMDG_RS13975 ENOG4105BZ1 (ABC) transporter FSYMDG_RS13980 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FSYMDG_RS13985 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FSYMDG_RS13995 ENOG4105E8G Major facilitator Superfamily FSYMDG_RS14040 ENOG4105CJ1 ABC, transporter FSYMDG_RS14080 ENOG41086KC Transcriptional regulator FSYMDG_RS14110 ENOG4106A3M Cytochrome p-450 FSYMDG_RS14120 ENOG4106NZI LysR family Transcriptional regulator FSYMDG_RS14140 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FSYMDG_RS14155 ENOG4105DRS transport system, permease FSYMDG_RS14180 ENOG4106A3M Cytochrome p-450 FSYMDG_RS14185 ENOG4106A3M Cytochrome p-450 FSYMDG_RS14220 ENOG4105CEY Amp-dependent synthetase and ligase FSYMDG_RS14225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FSYMDG_RS14235 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FSYMDG_RS14270 ENOG4107RCI amp-dependent synthetase and ligase FSYMDG_RS14275 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FSYMDG_RS14280 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FSYMDG_RS14290 ENOG4107QKG PfaD family FSYMDG_RS14295 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FSYMDG_RS14345 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FSYMDG_RS14350 ENOG4108IQE Amp-dependent synthetase and ligase FSYMDG_RS14380 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FSYMDG_RS14385 ENOG4107RCI amp-dependent synthetase and ligase FSYMDG_RS14440 ENOG4107R13 MMPL domain protein FSYMDG_RS14455 ENOG4106BRA Membrane FSYMDG_RS14530 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FSYMDG_RS14620 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS14680 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FSYMDG_RS14685 ENOG4108N23 SpoOM-related protein FSYMDG_RS14735 ENOG4105C0I Conserved Protein FSYMDG_RS14740 ENOG4108ZHJ Organic hydroperoxide resistance protein FSYMDG_RS14750 ENOG4105C29 acyl-CoA thioesterase FSYMDG_RS14755 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FSYMDG_RS14760 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FSYMDG_RS14765 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FSYMDG_RS14785 ENOG4105C1G acyl-Coa dehydrogenase FSYMDG_RS14795 ENOG4105CEY Amp-dependent synthetase and ligase FSYMDG_RS14800 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase FSYMDG_RS14850 ENOG4105CHU acetyl-coa acetyltransferase FSYMDG_RS14855 ENOG4105E39 Enoyl-CoA hydratase FSYMDG_RS14875 ENOG4105BZU Histidine kinase FSYMDG_RS14925 ENOG4106A3M Cytochrome p-450 FSYMDG_RS14930 ENOG4107RCI amp-dependent synthetase and ligase FSYMDG_RS14940 ENOG4106A3M Cytochrome p-450 FSYMDG_RS14990 ENOG4105EGD dinuclear metal center protein, YbgI family FSYMDG_RS15025 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FSYMDG_RS15050 ENOG4105EWK phytoene FSYMDG_RS15055 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FSYMDG_RS15060 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FSYMDG_RS15070 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FSYMDG_RS15080 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FSYMDG_RS15085 ENOG4105CHR reductase FSYMDG_RS15090 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FSYMDG_RS15095 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FSYMDG_RS15105 ENOG4105D8K carboxyl transferase FSYMDG_RS15130 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FSYMDG_RS15150 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FSYMDG_RS15155 ENOG4105DFA alanine racemase domain protein FSYMDG_RS15165 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FSYMDG_RS15185 ENOG4105MZG transcriptional modulator of maze toxin, mazf FSYMDG_RS15195 ENOG4105EC2 ftsk spoIIIe FSYMDG_RS15260 ENOG4105CNA YD repeat protein FSYMDG_RS15300 ENOG4105DFU Cell wall formation (By similarity) FSYMDG_RS15305 ENOG4105DFU Cell wall formation (By similarity) FSYMDG_RS15310 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FSYMDG_RS15315 ENOG4108JQ1 Dehydrogenase FSYMDG_RS15365 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FSYMDG_RS15375 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FSYMDG_RS15380 ENOG4105CJN penicillin-binding protein FSYMDG_RS15390 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FSYMDG_RS15395 ENOG4108V6E Cell division protein mraZ FSYMDG_RS15400 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FSYMDG_RS15450 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FSYMDG_RS15460 ENOG4107QVM von Willebrand factor, type A FSYMDG_RS15465 ENOG4105VEQ Cold shock protein FSYMDG_RS15485 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FSYMDG_RS15515 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase FSYMDG_RS15520 ENOG4105CTQ phosphohexokinase FSYMDG_RS15565 ENOG4105DKQ ROK family FSYMDG_RS15595 ENOG4105JNK Glycosyl transferase (Group 1 FSYMDG_RS15680 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FSYMDG_RS15685 ENOG4107EUI c reductase, iron-sulfur FSYMDG_RS15690 ENOG4107UDY cytochrome C FSYMDG_RS15695 ENOG4105CCU oxidase (Subunit III) FSYMDG_RS15710 ENOG4108RAC Rubrerythrin FSYMDG_RS15725 ENOG4108I0Q anthranilate phosphoribosyltransferase FSYMDG_RS15730 ENOG4108ZRS Part of cytochrome c oxidase, its function is FSYMDG_RS15740 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FSYMDG_RS15765 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FSYMDG_RS15770 ENOG4107T4Z adenosine kinase FSYMDG_RS15780 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FSYMDG_RS15790 ENOG4105CPC Aldo Keto reductase FSYMDG_RS15810 ENOG4107Y2X deaminase FSYMDG_RS15835 ENOG4105EMU Dehydrogenase FSYMDG_RS15850 ENOG4108YIQ Alpha beta hydrolase FSYMDG_RS15860 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FSYMDG_RS15865 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FSYMDG_RS15870 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FSYMDG_RS15875 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FSYMDG_RS15895 ENOG4108QVN serine threonine protein kinase FSYMDG_RS15900 ENOG4105EC3 peptidase S51, dipeptidase E FSYMDG_RS15905 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FSYMDG_RS15910 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FSYMDG_RS15935 ENOG4105C5F glutamine synthetase FSYMDG_RS15945 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FSYMDG_RS15960 ENOG4105C5F glutamine synthetase FSYMDG_RS15965 ENOG4105C4K Nad synthetase FSYMDG_RS15970 ENOG4108JGH Tetr family transcriptional regulator FSYMDG_RS15975 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FSYMDG_RS16040 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FSYMDG_RS16045 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FSYMDG_RS16055 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FSYMDG_RS16060 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FSYMDG_RS16080 ENOG4105DSU hydrolase FSYMDG_RS16110 ENOG4105KVH Transcriptional regulator FSYMDG_RS16115 ENOG4105KVH Transcriptional regulator FSYMDG_RS16160 ENOG4105CH7 arginosuccinase FSYMDG_RS16165 ENOG4105CDH Citrulline--aspartate ligase FSYMDG_RS16170 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FSYMDG_RS16175 ENOG4105DBV ornithine carbamoyltransferase FSYMDG_RS16180 ENOG4105C8Y Acetylornithine aminotransferase FSYMDG_RS16185 ENOG4105CAS nag kinase FSYMDG_RS16190 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FSYMDG_RS16195 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FSYMDG_RS16215 ENOG4105E18 UPF0276 protein FSYMDG_RS16225 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FSYMDG_RS16230 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FSYMDG_RS16235 ENOG4105BZU Histidine kinase FSYMDG_RS16240 ENOG4108RWN rrna methyltransferase FSYMDG_RS16245 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FSYMDG_RS16250 ENOG41084BS 50S ribosomal protein L35 FSYMDG_RS16255 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FSYMDG_RS16270 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FSYMDG_RS16275 ENOG4105C0R drug resistance transporter emrb qaca subfamily FSYMDG_RS16285 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FSYMDG_RS16290 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FSYMDG_RS16305 ENOG4105DJV ribulose-phosphate 3-epimerase FSYMDG_RS16330 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FSYMDG_RS16335 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FSYMDG_RS16340 ENOG4107RSZ Primosomal protein n' FSYMDG_RS16350 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FSYMDG_RS16360 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FSYMDG_RS16365 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FSYMDG_RS16375 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FSYMDG_RS16380 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FSYMDG_RS16385 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FSYMDG_RS16395 ENOG4105CD3 dihydroorotase FSYMDG_RS16400 ENOG4105CXT aspartate transcarbamylase FSYMDG_RS16405 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FSYMDG_RS16415 ENOG410803B Involved in the transcription termination process (By similarity) FSYMDG_RS16420 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FSYMDG_RS16425 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FSYMDG_RS16430 ENOG4105D49 3-dehydroquinate synthase FSYMDG_RS16435 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FSYMDG_RS16440 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FSYMDG_RS16455 ENOG4105HHA aminodeoxychorismate lyase FSYMDG_RS16460 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FSYMDG_RS16535 ENOG4106A3M Cytochrome p-450 FSYMDG_RS16545 ENOG4105F95 Monooxygenase FSYMDG_RS16550 ENOG4105C1G acyl-Coa dehydrogenase FSYMDG_RS16565 ENOG410846T CoA-transferase family III FSYMDG_RS16580 ENOG4105C2J ABC transporter FSYMDG_RS16595 ENOG4105C0B DNA polymerase III (alpha subunit) FSYMDG_RS16650 ENOG4107ZHV Transcriptional regulator FSYMDG_RS16665 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FSYMDG_RS16685 ENOG4105CHR reductase FSYMDG_RS16690 ENOG4105DEF Extracellular solute-binding protein, family 5 FSYMDG_RS16700 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSYMDG_RS16745 ENOG4108UCS ABC, transporter FSYMDG_RS16750 ENOG4105FAV ABC, transporter FSYMDG_RS16770 ENOG4105D5G Transposase FSYMDG_RS16790 ENOG4105CKI cobalamin synthesis protein FSYMDG_RS16805 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FSYMDG_RS16810 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FSYMDG_RS16820 ENOG4107T8P acyl-Coa dehydrogenase FSYMDG_RS16830 ENOG4105FBW Monooxygenase FSYMDG_RS16890 ENOG4105D7V transposase FSYMDG_RS16950 ENOG410841Q phosphoesterase PA-phosphatase related protein FSYMDG_RS16970 ENOG4105VG9 Plasmid stabilization system FSYMDG_RS16990 ENOG4105HX0 Transcriptional regulator FSYMDG_RS17000 ENOG4108IJG ABC transporter substrate-binding protein FSYMDG_RS17020 ENOG4105DRS transport system, permease FSYMDG_RS17075 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FSYMDG_RS17175 ENOG4105CHU acetyl-coa acetyltransferase FSYMDG_RS17195 ENOG4105C26 Dehydrogenase FSYMDG_RS17215 ENOG4105ETX regulatoR FSYMDG_RS17230 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FSYMDG_RS17240 ENOG4105ESN nucleotide-binding protein FSYMDG_RS17250 ENOG4105DQR SNARE associated Golgi FSYMDG_RS17340 ENOG4105VXP Protein of unknown function DUF86 FSYMDG_RS17365 ENOG41065RQ ADP-ribosylation crystallin J1 FSYMDG_RS17375 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FSYMDG_RS17380 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FSYMDG_RS17430 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FSYMDG_RS17445 ENOG4105CQ7 ATP-dependent helicase FSYMDG_RS17450 ENOG4105CPC Aldo Keto reductase FSYMDG_RS17480 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS17530 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FSYMDG_RS17535 ENOG4105MWK D-amino acid dehydrogenase, small subunit FSYMDG_RS17540 ENOG4105CHH sulfate transporter FSYMDG_RS17550 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FSYMDG_RS17560 ENOG4108QV3 biosynthesis protein FSYMDG_RS17570 ENOG4105M2Z protein tyrosine serine phosphatase FSYMDG_RS17590 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FSYMDG_RS17595 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FSYMDG_RS17610 ENOG4105DWV Homoserine O-trans-acetylase FSYMDG_RS17620 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FSYMDG_RS17660 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FSYMDG_RS17665 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FSYMDG_RS17690 ENOG4107TB5 TRANSCRIPTIONal FSYMDG_RS17695 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FSYMDG_RS17715 ENOG4105DKW ABC transporter FSYMDG_RS17725 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FSYMDG_RS17730 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FSYMDG_RS17740 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FSYMDG_RS17745 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FSYMDG_RS17755 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FSYMDG_RS17760 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FSYMDG_RS17765 ENOG4108NJZ Sensory box GGDEF EAL domain protein FSYMDG_RS17770 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FSYMDG_RS17785 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FSYMDG_RS17790 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) FSYMDG_RS17795 ENOG4105KC9 Modulates RecA activity (By similarity) FSYMDG_RS17800 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FSYMDG_RS17810 ENOG4107QRT dEAD DEAH box helicase FSYMDG_RS17830 ENOG4105CEV competence damage-inducible protein FSYMDG_RS17840 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FSYMDG_RS17860 ENOG4107QZI cell division protein FtsK FSYMDG_RS17865 ENOG4105CN5 Metallo-Beta-Lactamase FSYMDG_RS17870 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FSYMDG_RS17880 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FSYMDG_RS17890 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FSYMDG_RS17900 ENOG4105CFG Acts as a chaperone (By similarity) FSYMDG_RS17910 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FSYMDG_RS17915 ENOG4105C1V Peptidase, M16 FSYMDG_RS17920 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FSYMDG_RS17925 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FSYMDG_RS17935 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FSYMDG_RS17940 ENOG4105SFS phosphoesterase RecJ domain protein FSYMDG_RS17945 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FSYMDG_RS17955 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FSYMDG_RS17965 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) FSYMDG_RS18005 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FSYMDG_RS18015 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FSYMDG_RS18025 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FSYMDG_RS18035 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FSYMDG_RS18040 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FSYMDG_RS18045 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FSYMDG_RS18050 ENOG4105CE9 30S ribosomal protein S2 FSYMDG_RS18085 ENOG41080R2 UPF0102 protein FSYMDG_RS18095 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FSYMDG_RS18105 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FSYMDG_RS18110 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FSYMDG_RS18115 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FSYMDG_RS18125 ENOG4105K5M 30s ribosomal protein S16 FSYMDG_RS18145 ENOG4108375 Acylphosphatase (EC 3.6.1.7) FSYMDG_RS18160 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FSYMDG_RS18165 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FSYMDG_RS18170 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FSYMDG_RS18190 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FSYMDG_RS18195 ENOG4106H78 methyltransferase FSYMDG_RS18205 ENOG4105VB9 50S ribosomal protein l28 FSYMDG_RS18210 ENOG4105DWF phosphomethylpyrimidine kinase FSYMDG_RS18230 ENOG4105CPF Cell wall formation (By similarity) FSYMDG_RS18235 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FSYMDG_RS18250 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FSYMDG_RS18255 ENOG4105K70 DNA-binding protein FSYMDG_RS18260 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FSYMDG_RS18265 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FSYMDG_RS18270 ENOG41069M3 Transcriptional regulator FSYMDG_RS18275 ENOG4105IJJ transcriptional regulator, crp fnr family FSYMDG_RS18285 ENOG4105C08 Histidine kinase FSYMDG_RS18305 ENOG4105E09 nadh pyrophosphatase FSYMDG_RS18370 ENOG4105C2M dna polymerase I FSYMDG_RS18400 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FSYMDG_RS18435 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FSYMDG_RS18470 ENOG4106W5V Membrane FSYMDG_RS18490 ENOG4105CM2 brancheD-chain amino acid aminotransferase FSYMDG_RS18495 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FSYMDG_RS18500 ENOG4105BZU Histidine kinase FSYMDG_RS18505 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FSYMDG_RS18520 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FSYMDG_RS18535 ENOG4105D5G Transposase FSYMDG_RS18550 ENOG4105CJN penicillin-binding protein FSYMDG_RS18555 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FSYMDG_RS18565 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FSYMDG_RS18570 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FSYMDG_RS18575 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FSYMDG_RS18585 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FSYMDG_RS18595 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FSYMDG_RS18630 ENOG4105D5P Methylmalonyl-coA mutase FSYMDG_RS18635 ENOG4105C10 Electron transfer flavoprotein FSYMDG_RS18670 ENOG4105D0M Protease HtpX homolog FSYMDG_RS18675 ENOG4105EVB acetyltransferase FSYMDG_RS18705 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FSYMDG_RS18710 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FSYMDG_RS18750 ENOG4105CFG Acts as a chaperone (By similarity) FSYMDG_RS18775 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FSYMDG_RS18785 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) FSYMDG_RS18790 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FSYMDG_RS18795 ENOG4105K63 Thioredoxin FSYMDG_RS18805 ENOG4105BZU Histidine kinase FSYMDG_RS18815 ENOG4105CHU acetyl-coa acetyltransferase FSYMDG_RS18865 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) FSYMDG_RS18875 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FSYMDG_RS18900 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FSYMDG_RS18910 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FSYMDG_RS18915 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FSYMDG_RS18920 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FSYMDG_RS18925 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FSYMDG_RS18930 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FSYMDG_RS18935 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) FSYMDG_RS18940 ENOG4105ZA1 atp synthase FSYMDG_RS18945 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) FSYMDG_RS18965 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FSYMDG_RS18970 ENOG4107UIY sua5 ycio yrdc ywlc family protein FSYMDG_RS18975 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FSYMDG_RS18980 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FSYMDG_RS18985 ENOG4105VFB Binds the 23S rRNA (By similarity) FSYMDG_RS19000 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FSYMDG_RS19005 ENOG4105D6E homoserine dehydrogenase FSYMDG_RS19010 ENOG4105C75 arginyL-tRNA synthetase FSYMDG_RS19030 ENOG4105CIG ABC transporter FSYMDG_RS19040 ENOG4106UX7 integral membrane protein FSYMDG_RS19045 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E FSYMDG_RS19050 ENOG4108903 Formimidoylglutamase FSYMDG_RS19055 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FSYMDG_RS19065 ENOG4105K4I Scp-like extracellular FSYMDG_RS19080 ENOG4108M6P methyltransferase FSYMDG_RS19100 ENOG4105CRK lysyL-tRNA synthetase FSYMDG_RS19120 ENOG4105P52 geranylgeranyl reductase FSYMDG_RS19145 ENOG4105DC1 bifunctional purine biosynthesis protein purh FSYMDG_RS19170 ENOG4105CMV Succinyl-CoA synthetase subunit beta FSYMDG_RS19185 ENOG4105DR5 peptidase FSYMDG_RS19195 ENOG4105C7B Threonine dehydratase FSYMDG_RS19200 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FSYMDG_RS19210 ENOG4105GWZ Roadblock lc7 family protein FSYMDG_RS19240 ENOG4107QVP Dehydrogenase FSYMDG_RS19265 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FSYMDG_RS19270 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FSYMDG_RS19275 ENOG4108IAJ Nad-dependent epimerase dehydratase FSYMDG_RS19285 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FSYMDG_RS19290 ENOG4108MJ3 acetyltransferase FSYMDG_RS19300 ENOG4108097 ATP-binding protein FSYMDG_RS19305 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FSYMDG_RS19310 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FSYMDG_RS19325 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FSYMDG_RS19330 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FSYMDG_RS19335 ENOG4108UJD 30S ribosomal protein S9 FSYMDG_RS19340 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FSYMDG_RS19350 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FSYMDG_RS19360 ENOG4108ZT0 50S ribosomal protein l17 FSYMDG_RS19365 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FSYMDG_RS19370 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FSYMDG_RS19375 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FSYMDG_RS19380 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FSYMDG_RS19390 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FSYMDG_RS19400 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FSYMDG_RS19410 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FSYMDG_RS19415 ENOG410849U 50S ribosomal protein L30 FSYMDG_RS19420 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FSYMDG_RS19425 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FSYMDG_RS19430 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FSYMDG_RS19435 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FSYMDG_RS19440 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FSYMDG_RS19445 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FSYMDG_RS19450 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FSYMDG_RS19455 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FSYMDG_RS19460 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FSYMDG_RS19465 ENOG41082SA 50s ribosomal protein l29 FSYMDG_RS19470 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FSYMDG_RS19475 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FSYMDG_RS19480 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FSYMDG_RS19485 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FSYMDG_RS19490 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FSYMDG_RS19495 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FSYMDG_RS19500 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FSYMDG_RS19505 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FSYMDG_RS19510 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FSYMDG_RS19515 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FSYMDG_RS19520 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FSYMDG_RS19525 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FSYMDG_RS19530 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FSYMDG_RS19550 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FSYMDG_RS19555 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FSYMDG_RS19560 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FSYMDG_RS19565 ENOG4108VZM 50s ribosomal protein L10 FSYMDG_RS19570 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FSYMDG_RS19575 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FSYMDG_RS19580 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FSYMDG_RS19605 ENOG410900P UPF0336 protein FSYMDG_RS19610 ENOG4105WDJ 50S ribosomal protein L33 FSYMDG_RS19640 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FSYMDG_RS19655 ENOG4108VPT UPF0234 protein FSYMDG_RS19660 ENOG4105D0M Protease HtpX homolog FSYMDG_RS19670 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FSYMDG_RS19675 ENOG4105DQU oxidoreductase, subunit beta FSYMDG_RS19690 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FSYMDG_RS19705 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FSYMDG_RS19710 ENOG41087XN oxidoreductase FSYMDG_RS19720 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FSYMDG_RS19725 ENOG4108IEH NADH dehydrogenase subunit g FSYMDG_RS19740 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FSYMDG_RS19745 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FSYMDG_RS19770 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FSYMDG_RS19775 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FSYMDG_RS19780 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) FSYMDG_RS19785 ENOG4105CAY ferredoxin--nadp reductase FSYMDG_RS19800 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FSYMDG_RS19810 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS19820 ENOG4105EV6 Pfam:DUF178 FSYMDG_RS19835 ENOG4105DVY radical SAM domain protein FSYMDG_RS19850 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FSYMDG_RS19860 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FSYMDG_RS19870 ENOG4105CRE cytochrome C FSYMDG_RS19880 ENOG4107QIV Cytochrome c biogenesis protein FSYMDG_RS19885 ENOG4107QX9 Thiol disulfide interChange protein FSYMDG_RS19915 ENOG4108RH7 phosphoglycerate mutase FSYMDG_RS19920 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FSYMDG_RS19955 ENOG4105D52 delta-aminolevulinic acid dehydratase FSYMDG_RS19960 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FSYMDG_RS19965 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FSYMDG_RS20010 ENOG4105II7 pyrroline-5-carboxylate reductase FSYMDG_RS20020 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FSYMDG_RS20025 ENOG4105EY0 Xylose isomerase domain protein TIM barrel FSYMDG_RS20030 ENOG4107R33 ppx gppa phosphatase FSYMDG_RS20040 ENOG4105BZU Histidine kinase FSYMDG_RS20050 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FSYMDG_RS20060 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FSYMDG_RS20080 ENOG4105C99 atpase involved in dna repair FSYMDG_RS20095 ENOG4105CPC Aldo Keto reductase FSYMDG_RS20105 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FSYMDG_RS20115 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands FSYMDG_RS20130 ENOG4105PKJ carbohydrate binding FSYMDG_RS20135 ENOG4105KHC sulfurtransferase FSYMDG_RS20160 ENOG4107NHD transcriptional regulator FSYMDG_RS20170 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FSYMDG_RS20175 ENOG4105ETX regulatoR FSYMDG_RS20180 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FSYMDG_RS20200 ENOG41082AN stage II sporulation protein FSYMDG_RS20225 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase FSYMDG_RS20245 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction FSYMDG_RS20265 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS20325 ENOG4105CUT histidyl-tRNA synthetase FSYMDG_RS20345 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FSYMDG_RS20355 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FSYMDG_RS20360 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FSYMDG_RS20365 ENOG4105D9U N-acetyltransferase FSYMDG_RS20400 ENOG41082SX arsR family transcriptional regulator FSYMDG_RS20450 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS20465 ENOG4108V1T peptidylprolyl cis-trans isomerase FSYMDG_RS20560 ENOG41062D9 Histidine kinase FSYMDG_RS20565 ENOG4105ETX regulatoR FSYMDG_RS20600 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FSYMDG_RS20615 ENOG4105C1B dTDP-glucose 4-6-dehydratase FSYMDG_RS20620 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FSYMDG_RS20655 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FSYMDG_RS20685 ENOG4105C2J ABC transporter FSYMDG_RS20690 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FSYMDG_RS20705 ENOG4105CC5 ABC transporter FSYMDG_RS20710 ENOG4105CC5 ABC transporter FSYMDG_RS20715 ENOG4105DIK (ABC) transporter FSYMDG_RS20720 ENOG4105DSE periplasmic solute binding protein FSYMDG_RS20730 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FSYMDG_RS20735 ENOG4105KVH Transcriptional regulator FSYMDG_RS20780 ENOG4108Q50 Histidine kinase FSYMDG_RS20795 ENOG4105C1G acyl-Coa dehydrogenase FSYMDG_RS20825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FSYMDG_RS20850 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FSYMDG_RS20870 ENOG4105C0R drug resistance transporter emrb qaca subfamily FSYMDG_RS20890 ENOG4105XEA Tetr family transcriptional regulator FSYMDG_RS20905 ENOG4105FBN Acid phosphatase FSYMDG_RS20910 ENOG4105CDA abc transporter atp-binding protein FSYMDG_RS20915 ENOG4105CT1 (ABC) transporter FSYMDG_RS20920 ENOG4105EAD ABC transporter FSYMDG_RS20925 ENOG4105DRP amino acid AbC transporter FSYMDG_RS20930 ENOG4105E2B Taurine dioxygenase FSYMDG_RS20955 ENOG4105C19 ABC transporter FSYMDG_RS20960 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FSYMDG_RS21000 ENOG41080R8 Conserved Protein FSYMDG_RS21010 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FSYMDG_RS21040 ENOG4105C8N cysteinyl-tRNA synthetase FSYMDG_RS21050 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FSYMDG_RS21060 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FSYMDG_RS21065 ENOG4108VJ1 Transcriptional regulator (CarD family FSYMDG_RS21080 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FSYMDG_RS21085 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FSYMDG_RS21090 ENOG4105CEN a g-specific adenine glycosylase FSYMDG_RS21100 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FSYMDG_RS21110 ENOG4105BZU Histidine kinase FSYMDG_RS21205 ENOG4105D74 hydrolase FSYMDG_RS21245 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FSYMDG_RS21270 ENOG4105BZ4 penicillin-binding protein FSYMDG_RS21280 ENOG4105DIN metallophosphoesterase FSYMDG_RS21335 ENOG4105WN5 stage II sporulation protein FSYMDG_RS21345 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for FSYMDG_RS21350 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FSYMDG_RS21355 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FSYMDG_RS21360 ENOG4107QRG dna polymerase iii FSYMDG_RS21375 ENOG4105D7N magnesium and cobalt transport protein CorA FSYMDG_RS21400 ENOG41061AU MarR family Transcriptional regulator FSYMDG_RS21405 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FSYMDG_RS21410 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FSYMDG_RS21420 ENOG4108Z6B deaminase FSYMDG_RS21430 ENOG4107T65 Integrase FSYMDG_RS21435 ENOG4106CY5 excisionase FSYMDG_RS21440 ENOG4107ZVI PhiRv2 prophage protein FSYMDG_RS21535 ENOG4105DY8 decarboxylase FSYMDG_RS21545 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FSYMDG_RS21560 ENOG4105C12 Phosphoribosylglycinamide synthetase FSYMDG_RS21570 ENOG4105C83 adenylosuccinate lyase FSYMDG_RS21575 ENOG4105C8V SAICAR synthetase FSYMDG_RS21580 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FSYMDG_RS21585 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FSYMDG_RS21590 ENOG4108IYU L-aspartate oxidase FSYMDG_RS21600 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FSYMDG_RS21635 ENOG4105CPD ethanolamine ammonia-lyase FSYMDG_RS21815 ENOG4105C3Q Glycosyl transferase, family 2 FSYMDG_RS21825 ENOG4105VNT transposase (IS4 family) protein FSYMDG_RS21845 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FSYMDG_RS21940 ENOG4105DIK (ABC) transporter FSYMDG_RS21965 ENOG4105CPP Dehydrogenase, E1 component FSYMDG_RS21970 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 FSYMDG_RS21980 ENOG4105CSU acyl-Coa dehydrogenase FSYMDG_RS21995 ENOG4105F8J Adenylate Guanylate cyclase FSYMDG_RS22010 ENOG4107QP8 phosphohexose isomerase FSYMDG_RS22020 ENOG4105D9P serine threonine protein kinase FSYMDG_RS22025 ENOG4105E4C Lytic transglycosylase catalytic FSYMDG_RS22115 ENOG41067HS methyltransferase FSYMDG_RS22120 ENOG4105C01 Dihydroxy-acid dehydratase FSYMDG_RS22160 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FSYMDG_RS22165 ENOG4108KPJ rna polymerase sigma factor FSYMDG_RS22175 ENOG4105CDU Replicative dna helicase FSYMDG_RS22180 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FSYMDG_RS22185 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FSYMDG_RS22195 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) FSYMDG_RS22235 ENOG4105BZ4 penicillin-binding protein FSYMDG_RS22285 ENOG4105CJR Integral membrane protein (MviN FSYMDG_RS22290 ENOG4108V5V Serine Threonine protein kinase FSYMDG_RS22305 ENOG4105C3M thioredoxin reductase FSYMDG_RS22310 ENOG4105K63 Thioredoxin FSYMDG_RS22315 ENOG4108E1C hydrolase FSYMDG_RS22330 ENOG4107QJE Chromosome Partitioning Protein FSYMDG_RS22335 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FSYMDG_RS22435 ENOG4105BZU Histidine kinase FSYMDG_RS22455 ENOG4107NHD transcriptional regulator FSYMDG_RS22465 ENOG4105BZU Histidine kinase FSYMDG_RS22480 ENOG4105R8C Transcriptional regulator FSYMDG_RS22630 ENOG4108UGD Serine Threonine protein kinase FSYMDG_RS22715 ENOG4105CFG Acts as a chaperone (By similarity) FSYMDG_RS22765 ENOG4107TPY serine threonine protein kinase FSYMDG_RS22770 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FSYMDG_RS22855 ENOG4105D9P serine threonine protein kinase FSYMDG_RS22865 ENOG4107YH6 single-stranded DNA-binding protein FSYMDG_RS22890 ENOG4105EYH Exonuclease FSYMDG_RS22900 ENOG4105CNF WD-40 repeat protein FSYMDG_RS22910 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FSYMDG_RS22980 ENOG4107RIQ Sulfate adenylate transferase FSYMDG_RS23005 ENOG4105VT3 DNA binding domain protein, excisionase family FSYMDG_RS23015 ENOG4105WBV Transcriptional regulator FSYMDG_RS23095 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FSYMDG_RS23115 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FSYMDG_RS23120 ENOG4105K4H Nlp p60 protein FSYMDG_RS23185 ENOG4105BZU Histidine kinase FSYMDG_RS23195 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FSYMDG_RS23255 ENOG4107WYG Transcriptional regulator, luxr family FSYMDG_RS23260 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FSYMDG_RS23275 ENOG4108762 serine threonine protein kinase FSYMDG_RS23305 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FSYMDG_RS23360 ENOG4108VX5 3-methyladenine DNA glycosylase FSYMDG_RS23395 ENOG4105E2X shikimate dehydrogenase FSYMDG_RS23405 ENOG41067TZ transcriptional regulator, MarR family FSYMDG_RS23415 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FSYMDG_RS23425 ENOG4105BZU Histidine kinase FSYMDG_RS23435 ENOG4108UGD Serine Threonine protein kinase FSYMDG_RS23455 ENOG4105BZ1 (ABC) transporter FSYMDG_RS23465 ENOG41062BK proline dehydrogenase FSYMDG_RS23575 ENOG4107JC6 Membrane FSYMDG_RS23590 ENOG4105C0H protease FSYMDG_RS23630 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FSYMDG_RS23635 ENOG41084CH 50S ribosomal protein l34 FSYMDG_RS23655 ENOG4105BZ1 (ABC) transporter FSYMDG_RS23780 ENOG41080U6 GntR family transcriptional regulator FSYMDG_RS23895 ENOG4105K4I Scp-like extracellular FSYMDG_RS23955 ENOG4105EVB acetyltransferase FSYMDG_RS23970 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FSYMDG_RS24080 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FSYMDG_RS24105 ENOG4105FQ6 thiopurine methyltransferase FSYMDG_RS24210 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FSYMDG_RS24255 ENOG4105VZ9 UPF0235 protein FSYMDG_RS24400 ENOG4105WH1 Two component transcriptional regulator luxr family FSYMDG_RS24455 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FSYMDG_RS24460 ENOG410688J Ferredoxin FSYMDG_RS24535 ENOG4108JQ7 (ABC) transporter FSYMDG_RS24560 ENOG4107U32 Beta-lactamase domain protein FSYMDG_RS24680 ENOG4107QZF nitrite reductase NADPH large subunit FSYMDG_RS24805 ENOG4105EMU Dehydrogenase FSYMDG_RS24845 ENOG41084BZ 50S ribosomal protein L32 FSYMDG_RS24890 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) FSYMDG_RS24910 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FSYMDG_RS25045 ENOG4108I5C dEAD DEAH box helicase FSYMDG_RS25390 ENOG4105J7I hydrolase FSYMDG_RS25505 ENOG4105CEY Amp-dependent synthetase and ligase FSYMDG_RS25870 ENOG41061ZR Transcriptional regulator FSYMDG_RS25885 ENOG4105C0W non-ribosomal peptide synthetase FSYMDG_RS25990 ENOG4105VG1 fes assembly suf system protein FSYMDG_RS26110 ENOG4105KA0 thioesterase Superfamily protein FSYMDG_RS26335 ENOG4108YZT Adenosylcobinamide kinase FSYMDG_RS26510 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein