locus-tag	class	description
CRG89_RS00005	COG0459	protein refolding
CRG89_RS00025	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CRG89_RS00030	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CRG89_RS00035	COG1492	cobalamin metabolic process
CRG89_RS00040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRG89_RS00050	COG1522	sequence-specific DNA binding
CRG89_RS00055	COG0109	protoheme IX farnesyltransferase activity
CRG89_RS00065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CRG89_RS00110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CRG89_RS00150	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CRG89_RS00175	COG1215	transferase activity, transferring glycosyl groups
CRG89_RS00185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CRG89_RS00205	COG2242	protein methyltransferase activity
CRG89_RS00235	COG0301	tRNA thio-modification
CRG89_RS00240	COG0017	Asparaginyl-tRNA synthetase
CRG89_RS00250	COG0175	sulfate reduction
CRG89_RS00255	COG2046	Belongs to the sulfate adenylyltransferase family
CRG89_RS00265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CRG89_RS00285	COG2217	Heavy metal translocating P-type atpase
CRG89_RS00300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRG89_RS00305	COG0183	Belongs to the thiolase family
CRG89_RS00335	COG1252	NADH dehydrogenase
CRG89_RS00390	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRG89_RS00395	COG1394	ATPase activity, coupled to movement of substances
CRG89_RS00440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRG89_RS00460	COG0604	alcohol dehydrogenase
CRG89_RS00475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRG89_RS00475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRG89_RS00490	COG0402	S-adenosylhomocysteine deaminase activity
CRG89_RS00495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRG89_RS00515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CRG89_RS00525	COG0484	heat shock protein binding
CRG89_RS00545	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CRG89_RS00555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRG89_RS00555	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CRG89_RS00575	COG1324	tolerance protein
CRG89_RS00590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CRG89_RS00605	COG0006	proline dipeptidase activity
CRG89_RS00610	COG1522	sequence-specific DNA binding
CRG89_RS00620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CRG89_RS00650	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CRG89_RS00665	COG0494	nUDIX hydrolase
CRG89_RS00670	COG0432	Pfam Uncharacterised protein family UPF0047
CRG89_RS00680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CRG89_RS00690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CRG89_RS00695	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CRG89_RS00700	COG1078	dGTPase activity
CRG89_RS00710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CRG89_RS00765	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CRG89_RS00780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CRG89_RS00785	COG0174	glutamine synthetase
CRG89_RS00845	COG1518	maintenance of DNA repeat elements
CRG89_RS00855	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CRG89_RS00860	COG0484	heat shock protein binding
CRG89_RS00880	COG0430	RNA-3'-phosphate cyclase activity
CRG89_RS00885	COG1051	belongs to the nudix hydrolase family
CRG89_RS00885	COG1056	cytidyltransferase-related domain
CRG89_RS00890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CRG89_RS00900	COG0037	tRNA processing
CRG89_RS00905	COG0003	Pfam Anion-transporting ATPase
CRG89_RS00940	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CRG89_RS00965	COG0004	ammonium transporteR
CRG89_RS01005	COG1378	Sugar-specific transcriptional regulator TrmB
CRG89_RS01010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CRG89_RS01025	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CRG89_RS01090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CRG89_RS01095	COG0252	asparaginase activity
CRG89_RS01100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRG89_RS01110	COG0019	diaminopimelate decarboxylase activity
CRG89_RS01115	COG1254	Belongs to the acylphosphatase family
CRG89_RS01130	COG0573	inorganic phosphate transmembrane transporter activity
CRG89_RS01135	COG0573	inorganic phosphate transmembrane transporter activity
CRG89_RS01140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CRG89_RS01145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CRG89_RS01150	COG0704	Plays a role in the regulation of phosphate uptake
CRG89_RS01155	COG0004	ammonium transporteR
CRG89_RS01170	COG0347	Belongs to the P(II) protein family
CRG89_RS01255	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CRG89_RS01305	COG0778	Nitroreductase
CRG89_RS01320	COG1234	tRNA 3'-trailer cleavage
CRG89_RS01325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CRG89_RS01330	COG0302	gtp cyclohydrolase
CRG89_RS01335	COG0602	queuosine metabolic process
CRG89_RS01340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CRG89_RS01345	COG0535	radical SAM domain protein
CRG89_RS01355	COG0083	homoserine kinase activity
CRG89_RS01370	COG0531	amino acid
CRG89_RS01390	COG1201	RNA secondary structure unwinding
CRG89_RS01410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CRG89_RS01440	COG1797	cobyrinic acid a,c-diamide synthase activity
CRG89_RS01460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CRG89_RS01490	COG1215	transferase activity, transferring glycosyl groups
CRG89_RS01505	COG1136	(ABC) transporter
CRG89_RS01515	COG1136	(ABC) transporter
CRG89_RS01515	COG0577	efflux transmembrane transporter activity
CRG89_RS01550	COG2151	metal-sulfur cluster biosynthetic enzyme
CRG89_RS01560	COG1691	(AIR) carboxylase
CRG89_RS01565	COG0644	oxidoreductase
CRG89_RS01575	COG2086	electron transfer activity
CRG89_RS01580	COG0039	L-malate dehydrogenase activity
CRG89_RS01585	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CRG89_RS01590	COG1606	tRNA processing
CRG89_RS01605	COG4770	biotin carboxylase activity
CRG89_RS01610	COG0439	Biotin carboxylase
CRG89_RS01615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CRG89_RS01630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CRG89_RS01640	COG0546	phosphoglycolate phosphatase activity
CRG89_RS01655	COG1012	belongs to the aldehyde dehydrogenase family
CRG89_RS01675	COG2022	thiamine diphosphate biosynthetic process
CRG89_RS01675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRG89_RS01680	COG0436	Aminotransferase
CRG89_RS01710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CRG89_RS01805	COG0601	transmembrane transport
CRG89_RS01810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRG89_RS01820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CRG89_RS01825	COG0552	protein localization to endoplasmic reticulum
CRG89_RS01835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CRG89_RS01845	COG1404	Belongs to the peptidase S8 family
CRG89_RS01850	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CRG89_RS01875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRG89_RS01905	COG0783	Belongs to the Dps family
CRG89_RS01910	COG1522	sequence-specific DNA binding
CRG89_RS01915	COG0081	regulation of translation
CRG89_RS01980	COG3243	poly(R)-hydroxyalkanoic acid synthase
CRG89_RS01990	COG1012	belongs to the aldehyde dehydrogenase family
CRG89_RS01995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CRG89_RS02020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CRG89_RS02025	COG0142	geranyltranstransferase activity
CRG89_RS02030	COG1304	FMN binding
CRG89_RS02045	COG1355	regulation of microtubule-based process
CRG89_RS02050	COG0052	Belongs to the universal ribosomal protein uS2 family
CRG89_RS02055	COG0148	phosphopyruvate hydratase activity
CRG89_RS02070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CRG89_RS02090	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CRG89_RS02155	COG0085	RNA polymerase activity
CRG89_RS02185	COG0367	asparagine synthase
CRG89_RS02190	COG1024	Enoyl-CoA hydratase
CRG89_RS02195	COG0316	Belongs to the HesB IscA family
CRG89_RS02210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CRG89_RS02220	COG0151	Belongs to the GarS family
CRG89_RS02225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CRG89_RS02260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CRG89_RS02280	COG2222	sugar isomerase
CRG89_RS02290	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CRG89_RS02290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CRG89_RS02310	COG0072	phenylalanine-tRNA ligase activity
CRG89_RS02315	COG2154	pterin-4-alpha-carbinolamine dehydratase
CRG89_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
CRG89_RS02355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CRG89_RS02360	COG0525	valine-tRNA ligase activity
CRG89_RS02370	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CRG89_RS02390	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CRG89_RS02405	COG1525	nuclease
CRG89_RS02440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CRG89_RS02445	COG0495	leucyl-tRNA aminoacylation
CRG89_RS02460	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CRG89_RS02475	COG2096	Adenosyltransferase
CRG89_RS02485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRG89_RS02490	COG0471	metal ion transport
CRG89_RS02495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CRG89_RS02505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CRG89_RS02530	COG0189	ligase activity
CRG89_RS02535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRG89_RS02545	COG0714	Associated with various cellular activities
CRG89_RS02555	COG0494	nUDIX hydrolase
CRG89_RS02585	COG0346	lactoylglutathione lyase activity
CRG89_RS02590	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRG89_RS02590	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRG89_RS02600	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CRG89_RS02600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CRG89_RS02625	COG1196	nuclear chromosome segregation
CRG89_RS02630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CRG89_RS02635	COG0351	phosphomethylpyrimidine kinase
CRG89_RS02685	COG3118	belongs to the thioredoxin family
CRG89_RS02695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRG89_RS02750	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CRG89_RS02755	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CRG89_RS02780	COG0835	chemotaxis
CRG89_RS02785	COG2201	protein-glutamate methylesterase activity
CRG89_RS02790	COG2201	protein-glutamate methylesterase activity
CRG89_RS02795	COG0643	Histidine kinase
CRG89_RS02795	COG2198	Histidine kinase
CRG89_RS02810	COG3425	synthase
CRG89_RS02895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRG89_RS02910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CRG89_RS02945	COG0788	formyltetrahydrofolate deformylase activity
CRG89_RS02950	COG0668	transmembrane transport
CRG89_RS02980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CRG89_RS02995	COG0840	transmembrane signaling receptor activity
CRG89_RS03020	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CRG89_RS03040	COG0417	DNA replication proofreading
CRG89_RS03070	COG0165	Argininosuccinate lyase
CRG89_RS03090	COG0585	pseudouridine synthase activity
CRG89_RS03110	COG0805	protein transport
CRG89_RS03115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRG89_RS03120	COG4555	ABC transporter
CRG89_RS03165	COG0463	Glycosyl transferase, family 2
CRG89_RS03170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRG89_RS03175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRG89_RS03190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRG89_RS03205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRG89_RS03210	COG0501	Belongs to the peptidase M48B family
CRG89_RS03245	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CRG89_RS03260	COG0419	ATPase involved in DNA repair
CRG89_RS03280	COG0137	argininosuccinate synthase activity
CRG89_RS03290	COG0189	ligase activity
CRG89_RS03295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CRG89_RS03300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CRG89_RS03305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CRG89_RS03315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRG89_RS03330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CRG89_RS03350	COG0028	Belongs to the TPP enzyme family
CRG89_RS03355	COG0440	acetolactate synthase activity
CRG89_RS03360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRG89_RS03365	COG0473	3-isopropylmalate dehydrogenase activity
CRG89_RS03375	COG0017	Asparaginyl-tRNA synthetase
CRG89_RS03380	COG1131	(ABC) transporter
CRG89_RS03390	COG0444	Belongs to the ABC transporter superfamily
CRG89_RS03395	COG4608	Belongs to the ABC transporter superfamily
CRG89_RS03420	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
CRG89_RS03450	COG0116	Belongs to the methyltransferase superfamily
CRG89_RS03475	COG1522	sequence-specific DNA binding
CRG89_RS03540	COG4122	O-methyltransferase activity
CRG89_RS03560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRG89_RS03630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRG89_RS03650	COG0114	fumarate hydratase activity
CRG89_RS03655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRG89_RS03680	COG0537	adenosine 5'-monophosphoramidase activity
CRG89_RS03690	COG1920	GTP binding
CRG89_RS03695	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CRG89_RS03710	COG1160	GTP binding
CRG89_RS03730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CRG89_RS03735	COG0733	neurotransmitter:sodium symporter activity
CRG89_RS03760	COG0517	IMP dehydrogenase activity
CRG89_RS03780	COG1522	sequence-specific DNA binding
CRG89_RS03795	COG2095	MarC family integral membrane protein
CRG89_RS03805	COG1254	Belongs to the acylphosphatase family
CRG89_RS03880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CRG89_RS03895	COG1830	Aldolase
CRG89_RS03905	COG1063	alcohol dehydrogenase
CRG89_RS03915	COG0517	IMP dehydrogenase activity
CRG89_RS03940	COG1573	uracil-dna glycosylase
CRG89_RS03950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CRG89_RS03955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CRG89_RS03960	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CRG89_RS03975	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CRG89_RS03980	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRG89_RS03985	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRG89_RS03990	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CRG89_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
CRG89_RS04030	COG0463	Glycosyl transferase, family 2
CRG89_RS04055	COG0247	lactate metabolic process
CRG89_RS04055	COG0277	FAD linked oxidase domain protein
CRG89_RS04200	COG0433	COG0433 Predicted ATPase
CRG89_RS04320	COG1475	DNA binding
CRG89_RS04330	COG2205	protein histidine kinase activity
CRG89_RS04330	COG4999	Histidine kinase
CRG89_RS04330	COG3437	response regulator, receiver
CRG89_RS04330	COG3850	Histidine kinase
CRG89_RS04335	COG4413	Urea transporter
CRG89_RS04340	COG0831	urea catabolic process
CRG89_RS04350	COG0804	urea catabolic process
CRG89_RS04370	COG0830	nickel cation binding
CRG89_RS04395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRG89_RS04415	COG0579	oxidoreductase
CRG89_RS04435	COG0215	cysteine-tRNA ligase activity
CRG89_RS04440	COG1393	Belongs to the ArsC family
CRG89_RS04480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CRG89_RS04485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CRG89_RS04495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CRG89_RS04510	COG1201	RNA secondary structure unwinding
CRG89_RS04525	COG1064	alcohol dehydrogenase
CRG89_RS04530	COG0372	Belongs to the citrate synthase family
CRG89_RS04540	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CRG89_RS04545	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CRG89_RS04555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRG89_RS04585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRG89_RS04595	COG0012	GTP binding
CRG89_RS04605	COG1832	CoA-binding protein
CRG89_RS04640	COG0535	radical SAM domain protein
CRG89_RS04645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CRG89_RS04670	COG0284	orotidine-5'-phosphate decarboxylase activity
CRG89_RS04705	COG0009	L-threonylcarbamoyladenylate synthase
CRG89_RS04785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CRG89_RS04805	COG0312	modulator of DNA gyrase
CRG89_RS04815	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
CRG89_RS04820	COG0560	Phosphoserine phosphatase
CRG89_RS04835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CRG89_RS04850	COG0459	protein refolding
CRG89_RS04865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRG89_RS04875	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRG89_RS04880	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRG89_RS04885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRG89_RS04890	COG0778	Nitroreductase
CRG89_RS04905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CRG89_RS04910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CRG89_RS04930	COG2835	tetraacyldisaccharide 4'-kinase activity
CRG89_RS04940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CRG89_RS04980	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CRG89_RS04985	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CRG89_RS04995	COG0157	Belongs to the NadC ModD family
CRG89_RS05005	COG1185	polyribonucleotide nucleotidyltransferase activity
CRG89_RS05010	COG0489	protein tyrosine kinase activity
CRG89_RS05020	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CRG89_RS05035	COG3794	PFAM blue (type 1) copper domain protein
CRG89_RS05055	COG0047	phosphoribosylformylglycinamidine synthase activity
CRG89_RS05060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CRG89_RS05070	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CRG89_RS05075	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CRG89_RS05090	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CRG89_RS05095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CRG89_RS05110	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CRG89_RS05125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CRG89_RS05140	COG0255	Belongs to the universal ribosomal protein uL29 family
CRG89_RS05150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CRG89_RS05155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CRG89_RS05160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CRG89_RS05180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CRG89_RS05185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CRG89_RS05215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRG89_RS05240	COG0156	8-amino-7-oxononanoate synthase activity
CRG89_RS05245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRG89_RS05260	COG1980	fructose-bisphosphate aldolase activity
CRG89_RS05275	COG0051	transcription antitermination factor activity, RNA binding
CRG89_RS05280	COG2895	sulfate adenylyltransferase (ATP) activity
CRG89_RS05280	COG0529	Catalyzes the synthesis of activated sulfate
CRG89_RS05285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRG89_RS05285	COG0574	Belongs to the PEP-utilizing enzyme family
CRG89_RS05295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRG89_RS05300	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CRG89_RS05320	COG2094	Belongs to the DNA glycosylase MPG family
CRG89_RS05345	COG0560	Phosphoserine phosphatase
CRG89_RS05345	COG3830	Belongs to the UPF0237 family
CRG89_RS05350	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CRG89_RS05350	COG0778	Nitroreductase
CRG89_RS05425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRG89_RS05425	COG0512	Glutamine amidotransferase of anthranilate synthase
CRG89_RS05430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRG89_RS05440	COG0133	tryptophan synthase activity
CRG89_RS05445	COG0159	tryptophan synthase activity
CRG89_RS05455	COG0504	CTP synthase activity
CRG89_RS05460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CRG89_RS05470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CRG89_RS05490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CRG89_RS05495	COG0154	amidase activity
CRG89_RS05510	COG0017	Asparaginyl-tRNA synthetase
CRG89_RS05530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CRG89_RS05555	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CRG89_RS05560	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
CRG89_RS05565	COG1618	nucleotide phosphatase activity, acting on free nucleotides
CRG89_RS05575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CRG89_RS05595	COG0167	dihydroorotate dehydrogenase activity
CRG89_RS05600	COG0543	2 iron, 2 sulfur cluster binding
CRG89_RS05610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRG89_RS05615	COG1121	(ABC) transporter
CRG89_RS05620	COG0803	Belongs to the bacterial solute-binding protein 9 family
CRG89_RS05625	COG0864	Transcriptional regulator
CRG89_RS05630	COG0517	IMP dehydrogenase activity
CRG89_RS05630	COG0516	GMP reductase activity
CRG89_RS05660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CRG89_RS05680	COG0343	queuine tRNA-ribosyltransferase activity
CRG89_RS05790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CRG89_RS05805	COG0409	Hydrogenase expression formation protein
CRG89_RS05810	COG0298	carbon dioxide binding
CRG89_RS05835	COG2379	hydroxypyruvate reductase
CRG89_RS05855	COG0004	ammonium transporteR
CRG89_RS05880	COG1960	acyl-CoA dehydrogenase activity
CRG89_RS05890	COG1960	acyl-CoA dehydrogenase activity
CRG89_RS05935	COG0505	Belongs to the CarA family
CRG89_RS05970	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CRG89_RS05980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRG89_RS05980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRG89_RS05985	COG1056	cytidyltransferase-related domain
CRG89_RS05985	COG1051	belongs to the nudix hydrolase family
CRG89_RS05990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CRG89_RS06005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRG89_RS06005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRG89_RS06040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CRG89_RS06115	COG2133	pyrroloquinoline quinone binding
CRG89_RS06135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CRG89_RS06135	COG1213	nucleotidyl transferase
CRG89_RS06160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CRG89_RS06190	COG0529	Catalyzes the synthesis of activated sulfate
CRG89_RS06190	COG2046	Belongs to the sulfate adenylyltransferase family
CRG89_RS06240	COG1215	transferase activity, transferring glycosyl groups
CRG89_RS06265	COG0673	inositol 2-dehydrogenase activity
CRG89_RS06280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CRG89_RS06285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CRG89_RS06295	COG1028	Short-chain dehydrogenase reductase Sdr
CRG89_RS06300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRG89_RS06325	COG0105	UTP biosynthetic process
CRG89_RS06330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CRG89_RS06340	COG2132	Multicopper oxidase
CRG89_RS06345	COG3118	belongs to the thioredoxin family
CRG89_RS06375	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CRG89_RS06380	COG4829	muconolactone delta-isomerase
CRG89_RS06395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CRG89_RS06420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CRG89_RS06445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRG89_RS06485	COG0489	protein tyrosine kinase activity
CRG89_RS06490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRG89_RS06540	COG2897	thiosulfate sulfurtransferase activity
CRG89_RS06545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRG89_RS06545	COG0045	succinate-CoA ligase (ADP-forming) activity
CRG89_RS06545	COG1042	CoA-binding domain protein
CRG89_RS06550	COG3243	poly(R)-hydroxyalkanoic acid synthase
CRG89_RS06555	COG0509	glycine decarboxylation via glycine cleavage system
CRG89_RS06560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CRG89_RS06575	COG2226	methyltransferase
CRG89_RS06585	COG2081	HI0933 family
CRG89_RS06610	COG0109	protoheme IX farnesyltransferase activity
CRG89_RS06610	COG1612	heme a metabolic process
CRG89_RS06625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CRG89_RS06625	COG4651	solute:proton antiporter activity
CRG89_RS06700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CRG89_RS06720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CRG89_RS06730	COG0473	3-isopropylmalate dehydrogenase activity
CRG89_RS06750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CRG89_RS06760	COG0142	geranyltranstransferase activity
CRG89_RS06785	COG2226	methyltransferase
CRG89_RS06825	COG0433	COG0433 Predicted ATPase
CRG89_RS06870	COG3634	alkyl hydroperoxide reductase activity
CRG89_RS06905	COG1331	Highly conserved protein containing a thioredoxin domain
CRG89_RS06920	COG4956	integral membrane protein (PIN domain superfamily)
CRG89_RS06925	COG1335	isochorismatase
CRG89_RS06930	COG1321	iron dependent repressor
CRG89_RS06960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRG89_RS06985	COG0730	response to heat
CRG89_RS06990	COG0460	homoserine dehydrogenase
CRG89_RS07000	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CRG89_RS07015	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CRG89_RS07015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CRG89_RS07030	COG0018	arginyl-trna synthetase
CRG89_RS07035	COG0561	phosphatase activity
CRG89_RS07045	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRG89_RS07065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CRG89_RS07090	COG1793	dna ligase
CRG89_RS07100	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CRG89_RS07110	COG0492	ferredoxin-NADP+ reductase activity
CRG89_RS07115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRG89_RS07130	COG1830	Aldolase
CRG89_RS07135	COG1465	3-dehydroquinate synthase
CRG89_RS07145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CRG89_RS07155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CRG89_RS07170	COG0436	Aminotransferase
CRG89_RS07180	COG0494	nUDIX hydrolase
CRG89_RS07250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CRG89_RS07255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CRG89_RS07280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CRG89_RS07285	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CRG89_RS07320	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CRG89_RS07330	COG1914	H( )-stimulated, divalent metal cation uptake system
CRG89_RS07355	COG0066	3-isopropylmalate dehydratase activity
CRG89_RS07360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CRG89_RS07380	COG0124	histidyl-tRNA synthetase
CRG89_RS07410	COG0123	including yeast histone deacetylase and acetoin utilization protein
CRG89_RS07595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CRG89_RS07635	COG0049	tRNA binding
CRG89_RS07670	COG0445	tRNA wobble uridine modification
CRG89_RS07675	COG1515	deoxyribonuclease V activity
CRG89_RS07685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CRG89_RS07685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CRG89_RS07690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRG89_RS07695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CRG89_RS07705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CRG89_RS07710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CRG89_RS07725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRG89_RS07730	COG3958	Transketolase
CRG89_RS07735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRG89_RS07740	COG3959	Transketolase, thiamine diphosphate binding domain
CRG89_RS07745	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CRG89_RS07745	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CRG89_RS07760	COG1129	ABC transporter
CRG89_RS07795	COG0456	acetyltransferase
CRG89_RS07810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CRG89_RS07830	COG0328	RNA-DNA hybrid ribonuclease activity
CRG89_RS07840	COG0864	Transcriptional regulator
CRG89_RS07845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRG89_RS07850	COG1121	(ABC) transporter
CRG89_RS07855	COG0803	Belongs to the bacterial solute-binding protein 9 family
CRG89_RS07895	COG1007	ATP synthesis coupled electron transport
CRG89_RS07905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRG89_RS07910	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRG89_RS07925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRG89_RS07930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CRG89_RS07935	COG0649	NAD binding
CRG89_RS07940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRG89_RS07945	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRG89_RS07950	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRG89_RS07960	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CRG89_RS07965	COG0463	Glycosyl transferase, family 2
CRG89_RS07980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRG89_RS07990	COG1013	pyruvate-flavodoxin oxidoreductase activity
CRG89_RS07995	COG0674	pyruvate-flavodoxin oxidoreductase activity
CRG89_RS07995	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CRG89_RS08045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CRG89_RS08065	COG0200	Binds to the 23S rRNA
CRG89_RS08075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CRG89_RS08110	COG0671	phosphoesterase, PA-phosphatase related
CRG89_RS08115	COG0126	phosphoglycerate kinase activity
CRG89_RS08120	COG0822	iron-sulfur transferase activity
CRG89_RS08125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRG89_RS08140	COG0719	Fe-S assembly protein
CRG89_RS08150	COG1648	precorrin-2 dehydrogenase activity
CRG89_RS08150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CRG89_RS08155	COG0181	hydroxymethylbilane synthase activity
CRG89_RS08160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CRG89_RS08165	COG0113	porphobilinogen synthase activity
CRG89_RS08170	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CRG89_RS08175	COG1648	precorrin-2 dehydrogenase activity
CRG89_RS08175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CRG89_RS08180	COG1522	sequence-specific DNA binding
CRG89_RS08185	COG0667	Aldo Keto reductase
CRG89_RS08215	COG0396	ATPase activity
CRG89_RS08240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CRG89_RS08255	COG1064	alcohol dehydrogenase
CRG89_RS08280	COG0312	modulator of DNA gyrase
CRG89_RS08285	COG0312	modulator of DNA gyrase
CRG89_RS08320	COG1404	Belongs to the peptidase S8 family
CRG89_RS08340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CRG89_RS08345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CRG89_RS08350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRG89_RS08360	COG0131	Imidazoleglycerol-phosphate dehydratase
CRG89_RS08365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CRG89_RS08370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CRG89_RS08375	COG0107	imidazoleglycerol-phosphate synthase activity
CRG89_RS08385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CRG89_RS08400	COG1254	Belongs to the acylphosphatase family
CRG89_RS08415	COG2133	pyrroloquinoline quinone binding
CRG89_RS08455	COG0077	Prephenate dehydratase
CRG89_RS08455	COG1605	Chorismate mutase
CRG89_RS08470	COG0516	GMP reductase activity
CRG89_RS08470	COG0517	IMP dehydrogenase activity
CRG89_RS08480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CRG89_RS08495	COG0519	Catalyzes the synthesis of GMP from XMP
CRG89_RS08495	COG0518	GMP synthase (glutamine-hydrolyzing) activity