locus-tag	class	description
NSED_RS00015	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NSED_RS00030	COG1615	UPF0182 protein
NSED_RS00035	COG0519	Catalyzes the synthesis of GMP from XMP
NSED_RS00035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NSED_RS00085	COG1185	polyribonucleotide nucleotidyltransferase activity
NSED_RS00090	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NSED_RS00095	COG1797	cobyrinic acid a,c-diamide synthase activity
NSED_RS00125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NSED_RS00150	COG1131	(ABC) transporter
NSED_RS00180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NSED_RS00210	COG0252	asparaginase activity
NSED_RS00220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NSED_RS00225	COG1254	Belongs to the acylphosphatase family
NSED_RS00235	COG0037	tRNA processing
NSED_RS00240	COG0750	zinc metalloprotease
NSED_RS00265	COG1378	Sugar-specific transcriptional regulator TrmB
NSED_RS00270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NSED_RS00285	COG1091	dTDP-4-dehydrorhamnose reductase activity
NSED_RS00300	COG1216	Glycosyl transferase, family 2
NSED_RS00320	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NSED_RS00325	COG2151	metal-sulfur cluster biosynthetic enzyme
NSED_RS00360	COG0436	Aminotransferase
NSED_RS00380	COG0406	alpha-ribazole phosphatase activity
NSED_RS00395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NSED_RS00425	COG0784	Response regulator, receiver
NSED_RS00430	COG4191	Histidine kinase
NSED_RS00435	COG0500	methyltransferase
NSED_RS00455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NSED_RS00465	COG2226	methyltransferase
NSED_RS00500	COG2222	sugar isomerase
NSED_RS00520	COG0438	transferase activity, transferring glycosyl groups
NSED_RS00540	COG2304	oxidoreductase activity
NSED_RS00570	COG0109	protoheme IX farnesyltransferase activity
NSED_RS00580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NSED_RS00590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NSED_RS00595	COG1492	cobalamin metabolic process
NSED_RS00600	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NSED_RS00605	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NSED_RS00610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NSED_RS00625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NSED_RS00630	COG0459	protein refolding
NSED_RS00635	COG1940	carbohydrate kinase activity
NSED_RS00650	COG0519	Catalyzes the synthesis of GMP from XMP
NSED_RS00665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NSED_RS00670	COG0516	GMP reductase activity
NSED_RS00670	COG0517	IMP dehydrogenase activity
NSED_RS00680	COG0077	Prephenate dehydratase
NSED_RS00680	COG1605	Chorismate mutase
NSED_RS00715	COG2133	pyrroloquinoline quinone binding
NSED_RS00725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NSED_RS00730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NSED_RS00745	COG0131	Imidazoleglycerol-phosphate dehydratase
NSED_RS00750	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NSED_RS00755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NSED_RS00760	COG0107	imidazoleglycerol-phosphate synthase activity
NSED_RS00765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NSED_RS00775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NSED_RS00780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NSED_RS00790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NSED_RS00860	COG3118	belongs to the thioredoxin family
NSED_RS00890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NSED_RS00895	COG1355	regulation of microtubule-based process
NSED_RS00900	COG2078	PFAM AMMECR1 domain protein
NSED_RS00925	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NSED_RS00945	COG0788	formyltetrahydrofolate deformylase activity
NSED_RS00955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NSED_RS00975	COG0105	UTP biosynthetic process
NSED_RS00980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NSED_RS00985	COG3118	belongs to the thioredoxin family
NSED_RS01010	COG0586	Pfam SNARE associated Golgi protein
NSED_RS01020	COG1573	uracil-dna glycosylase
NSED_RS01025	COG0778	Nitroreductase
NSED_RS01080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NSED_RS01115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NSED_RS01135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NSED_RS01215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NSED_RS01220	COG0489	protein tyrosine kinase activity
NSED_RS01225	COG0165	Argininosuccinate lyase
NSED_RS01245	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NSED_RS01275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NSED_RS01280	COG0439	Biotin carboxylase
NSED_RS01290	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NSED_RS01295	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NSED_RS01300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NSED_RS01305	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NSED_RS01310	COG0649	NAD binding
NSED_RS01315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NSED_RS01320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NSED_RS01325	COG0839	Belongs to the complex I subunit 6 family
NSED_RS01335	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NSED_RS01340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NSED_RS01350	COG0142	geranyltranstransferase activity
NSED_RS01360	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
NSED_RS01435	COG0456	acetyltransferase
NSED_RS01450	COG1121	(ABC) transporter
NSED_RS01460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NSED_RS01480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NSED_RS01485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NSED_RS01510	COG2226	methyltransferase
NSED_RS01530	COG0179	Fumarylacetoacetate (FAA) hydrolase
NSED_RS01535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NSED_RS01540	COG0142	geranyltranstransferase activity
NSED_RS01560	COG0052	Belongs to the universal ribosomal protein uS2 family
NSED_RS01565	COG0148	phosphopyruvate hydratase activity
NSED_RS01585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NSED_RS01585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NSED_RS01590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NSED_RS01595	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NSED_RS01600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NSED_RS01605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NSED_RS01610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NSED_RS01660	COG1691	(AIR) carboxylase
NSED_RS01665	COG0039	L-malate dehydrogenase activity
NSED_RS01670	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
NSED_RS01675	COG1606	tRNA processing
NSED_RS01680	COG1104	cysteine desulfurase activity
NSED_RS01710	COG0085	RNA polymerase activity
NSED_RS01715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NSED_RS01750	COG0049	tRNA binding
NSED_RS01780	COG0778	Nitroreductase
NSED_RS01840	COG0495	leucyl-tRNA aminoacylation
NSED_RS01845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NSED_RS01865	COG2860	membrane
NSED_RS01890	COG1522	sequence-specific DNA binding
NSED_RS01930	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NSED_RS01935	COG1404	Belongs to the peptidase S8 family
NSED_RS01940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NSED_RS01950	COG0552	protein localization to endoplasmic reticulum
NSED_RS01965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NSED_RS01975	COG0200	Binds to the 23S rRNA
NSED_RS02000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NSED_RS02015	COG1475	DNA binding
NSED_RS02050	COG1917	Cupin 2, conserved barrel domain protein
NSED_RS02055	COG5285	phytanoyl-CoA dioxygenase
NSED_RS02155	COG0735	belongs to the Fur family
NSED_RS02170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NSED_RS02190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NSED_RS02200	COG0674	pyruvate-flavodoxin oxidoreductase activity
NSED_RS02200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NSED_RS02205	COG1013	pyruvate-flavodoxin oxidoreductase activity
NSED_RS02230	COG0778	Nitroreductase
NSED_RS02230	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NSED_RS02235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NSED_RS02240	COG0066	3-isopropylmalate dehydratase activity
NSED_RS02245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NSED_RS02250	COG0066	3-isopropylmalate dehydratase activity
NSED_RS02255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NSED_RS02260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NSED_RS02265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NSED_RS02295	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NSED_RS02330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NSED_RS02335	COG2897	thiosulfate sulfurtransferase activity
NSED_RS02350	COG1215	transferase activity, transferring glycosyl groups
NSED_RS02455	COG1131	(ABC) transporter
NSED_RS02475	COG1392	Phosphate transport regulator
NSED_RS02480	COG0306	phosphate transporter
NSED_RS02500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NSED_RS02505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NSED_RS02515	COG0181	hydroxymethylbilane synthase activity
NSED_RS02520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NSED_RS02520	COG1648	precorrin-2 dehydrogenase activity
NSED_RS02550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NSED_RS02565	COG0126	phosphoglycerate kinase activity
NSED_RS02570	COG0671	phosphoesterase, PA-phosphatase related
NSED_RS02605	COG1418	mRNA catabolic process
NSED_RS02615	COG0113	porphobilinogen synthase activity
NSED_RS02620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NSED_RS02625	COG1648	precorrin-2 dehydrogenase activity
NSED_RS02625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NSED_RS02630	COG1522	sequence-specific DNA binding
NSED_RS02640	COG0667	Aldo Keto reductase
NSED_RS02645	COG3253	May function as heme-dependent peroxidase
NSED_RS02650	COG1872	DUF167
NSED_RS02655	COG0396	ATPase activity
NSED_RS02680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NSED_RS02695	COG2197	response regulator
NSED_RS02715	COG1278	Cold shock
NSED_RS02740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NSED_RS02770	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
NSED_RS02810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NSED_RS02825	COG0436	Aminotransferase
NSED_RS02845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NSED_RS02850	COG0710	3-dehydroquinate dehydratase activity
NSED_RS02855	COG1465	3-dehydroquinate synthase
NSED_RS02860	COG1830	Aldolase
NSED_RS02865	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NSED_RS02870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NSED_RS02885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NSED_RS02890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NSED_RS03040	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NSED_RS03050	COG0519	Catalyzes the synthesis of GMP from XMP
NSED_RS03065	COG1528	Iron-storage protein
NSED_RS03095	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
NSED_RS03110	COG0475	glutathione-regulated potassium exporter activity
NSED_RS03115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NSED_RS03125	COG1253	flavin adenine dinucleotide binding
NSED_RS03140	COG0530	calcium, potassium:sodium antiporter activity
NSED_RS03145	COG0312	modulator of DNA gyrase
NSED_RS03150	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NSED_RS03155	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NSED_RS03160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NSED_RS03165	COG1216	Glycosyl transferase, family 2
NSED_RS03165	COG1442	glycosyl transferase family 8
NSED_RS03205	COG0024	Methionine aminopeptidase
NSED_RS03290	COG2226	methyltransferase
NSED_RS03300	COG0644	oxidoreductase
NSED_RS03345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NSED_RS03365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NSED_RS03395	COG1899	peptidyl-lysine modification to peptidyl-hypusine
NSED_RS03400	COG1260	myo-inositol-1-phosphate synthase
NSED_RS03410	COG1196	nuclear chromosome segregation
NSED_RS03415	COG4608	Belongs to the ABC transporter superfamily
NSED_RS03420	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NSED_RS03425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NSED_RS03430	COG0442	prolyl-tRNA aminoacylation
NSED_RS03440	COG0560	Phosphoserine phosphatase
NSED_RS03445	COG0778	Nitroreductase
NSED_RS03445	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NSED_RS03450	COG0018	arginyl-trna synthetase
NSED_RS03460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NSED_RS03480	COG2897	thiosulfate sulfurtransferase activity
NSED_RS03485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NSED_RS03510	COG0589	response to stress
NSED_RS03520	COG0517	IMP dehydrogenase activity
NSED_RS03520	COG0516	GMP reductase activity
NSED_RS03525	COG0589	response to stress
NSED_RS03530	COG0589	response to stress
NSED_RS03535	COG0517	IMP dehydrogenase activity
NSED_RS03540	COG0492	ferredoxin-NADP+ reductase activity
NSED_RS03560	COG0425	Belongs to the sulfur carrier protein TusA family
NSED_RS03580	COG0471	metal ion transport
NSED_RS03635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NSED_RS03640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NSED_RS03640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NSED_RS03650	COG2259	Doxx family
NSED_RS03665	COG0460	homoserine dehydrogenase
NSED_RS03670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NSED_RS03690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NSED_RS03770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NSED_RS03775	COG0601	transmembrane transport
NSED_RS03785	COG4895	conserved protein (DUF2196)
NSED_RS03825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NSED_RS03850	COG0277	FAD linked oxidase domain protein
NSED_RS04075	COG0484	heat shock protein binding
NSED_RS04095	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NSED_RS04125	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NSED_RS04135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NSED_RS04345	COG0163	prenyltransferase activity
NSED_RS04355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NSED_RS04360	COG0805	protein transport
NSED_RS04375	COG0047	phosphoribosylformylglycinamidine synthase activity
NSED_RS04380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NSED_RS04390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NSED_RS04405	COG4191	Histidine kinase
NSED_RS04470	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NSED_RS04475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NSED_RS04500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NSED_RS04505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NSED_RS04515	COG0255	Belongs to the universal ribosomal protein uL29 family
NSED_RS04525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NSED_RS04565	COG2133	pyrroloquinoline quinone binding
NSED_RS04585	COG0785	Cytochrome C biogenesis protein
NSED_RS04590	COG0156	8-amino-7-oxononanoate synthase activity
NSED_RS04600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NSED_RS04605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NSED_RS04620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NSED_RS04645	COG4536	flavin adenine dinucleotide binding
NSED_RS04650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NSED_RS04685	COG0183	Belongs to the thiolase family
NSED_RS04690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NSED_RS04715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NSED_RS04720	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NSED_RS04725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NSED_RS04750	COG0346	lactoylglutathione lyase activity
NSED_RS04810	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
NSED_RS04865	COG4962	Type ii secretion system protein e
NSED_RS04870	COG0745	RESPONSE REGULATOR receiver
NSED_RS04875	COG5002	protein histidine kinase activity
NSED_RS04900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NSED_RS04905	COG0154	amidase activity
NSED_RS04925	COG0017	Asparaginyl-tRNA synthetase
NSED_RS04950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NSED_RS04995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NSED_RS05130	COG1054	Belongs to the UPF0176 family
NSED_RS05175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NSED_RS05175	COG0512	Glutamine amidotransferase of anthranilate synthase
NSED_RS05180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NSED_RS05185	COG0134	indole-3-glycerol-phosphate synthase activity
NSED_RS05190	COG0133	tryptophan synthase activity
NSED_RS05195	COG0159	tryptophan synthase activity
NSED_RS05200	COG0504	CTP synthase activity
NSED_RS05225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NSED_RS05230	COG0010	Belongs to the arginase family
NSED_RS05235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NSED_RS05250	COG1899	peptidyl-lysine modification to peptidyl-hypusine
NSED_RS05285	COG0367	asparagine synthase
NSED_RS05420	COG0745	RESPONSE REGULATOR receiver
NSED_RS05430	COG2201	protein-glutamate methylesterase activity
NSED_RS05440	COG2226	methyltransferase
NSED_RS05445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NSED_RS05465	COG0417	DNA replication proofreading
NSED_RS05480	COG0574	Belongs to the PEP-utilizing enzyme family
NSED_RS05480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NSED_RS05495	COG0346	lactoylglutathione lyase activity
NSED_RS05520	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NSED_RS05520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NSED_RS05550	COG0308	aminopeptidase N
NSED_RS05580	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NSED_RS05580	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NSED_RS05585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NSED_RS05600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NSED_RS05610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NSED_RS05610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NSED_RS05615	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NSED_RS05620	COG2146	nitrite reductase [NAD(P)H] activity
NSED_RS05630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NSED_RS05635	COG0215	cysteine-tRNA ligase activity
NSED_RS05665	COG0668	transmembrane transport
NSED_RS05680	COG3272	Protein of unknown function (DUF1722)
NSED_RS05690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NSED_RS05695	COG0702	epimerase
NSED_RS05725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NSED_RS05735	COG1832	CoA-binding protein
NSED_RS05745	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NSED_RS05745	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NSED_RS05765	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NSED_RS05805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NSED_RS05835	COG3852	Histidine kinase
NSED_RS05855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NSED_RS05920	COG0672	)-iron permease
NSED_RS06110	COG0537	adenosine 5'-monophosphoramidase activity
NSED_RS06120	COG0431	NADPH-dependent FMN reductase
NSED_RS06130	COG1250	3-hydroxyacyl-CoA dehydrogenase
NSED_RS06160	COG2895	sulfate adenylyltransferase (ATP) activity
NSED_RS06165	COG1980	fructose-bisphosphate aldolase activity
NSED_RS06175	COG1793	dna ligase
NSED_RS06200	COG1028	Short-chain dehydrogenase reductase Sdr
NSED_RS06210	COG0730	response to heat
NSED_RS06230	COG1321	iron dependent repressor
NSED_RS06240	COG2201	protein-glutamate methylesterase activity
NSED_RS06260	COG1573	uracil-dna glycosylase
NSED_RS06265	COG2094	Belongs to the DNA glycosylase MPG family
NSED_RS06285	COG0444	Belongs to the ABC transporter superfamily
NSED_RS06295	COG0017	Asparaginyl-tRNA synthetase
NSED_RS06320	COG0473	3-isopropylmalate dehydrogenase activity
NSED_RS06325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NSED_RS06330	COG0440	acetolactate synthase activity
NSED_RS06335	COG0028	Belongs to the TPP enzyme family
NSED_RS06350	COG1063	alcohol dehydrogenase
NSED_RS06390	COG0505	Belongs to the CarA family
NSED_RS06395	COG1222	aaa ATPase
NSED_RS06420	COG0251	oxidation-reduction process
NSED_RS06445	COG0372	Belongs to the citrate synthase family
NSED_RS06460	COG3794	PFAM blue (type 1) copper domain protein
NSED_RS06475	COG0556	nucleotide-excision repair
NSED_RS06505	COG1454	alcohol dehydrogenase
NSED_RS06510	COG2379	hydroxypyruvate reductase
NSED_RS06525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NSED_RS06545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NSED_RS06550	COG0151	Belongs to the GarS family
NSED_RS06570	COG0045	succinate-CoA ligase (ADP-forming) activity
NSED_RS06575	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NSED_RS06590	COG4191	Histidine kinase
NSED_RS06620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NSED_RS06655	COG1945	arginine decarboxylase activity
NSED_RS06670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NSED_RS06670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NSED_RS06690	COG0589	response to stress
NSED_RS06695	COG0589	response to stress
NSED_RS06700	COG1301	dicarboxylic acid transport
NSED_RS06725	COG5002	protein histidine kinase activity
NSED_RS06840	COG1331	Highly conserved protein containing a thioredoxin domain
NSED_RS06885	COG0585	pseudouridine synthase activity
NSED_RS06925	COG0109	protoheme IX farnesyltransferase activity
NSED_RS06960	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NSED_RS06975	COG0489	protein tyrosine kinase activity
NSED_RS06980	COG1185	polyribonucleotide nucleotidyltransferase activity
NSED_RS06990	COG0157	Belongs to the NadC ModD family
NSED_RS07000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NSED_RS07005	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
NSED_RS07060	COG3794	PFAM blue (type 1) copper domain protein
NSED_RS07105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NSED_RS07115	COG1027	Aspartate ammonia-lyase
NSED_RS07120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NSED_RS07140	COG0494	nUDIX hydrolase
NSED_RS07150	COG0646	methionine synthase
NSED_RS07150	COG1410	methionine synthase
NSED_RS07155	COG1410	methionine synthase
NSED_RS07155	COG0646	methionine synthase
NSED_RS07185	COG0137	argininosuccinate synthase activity
NSED_RS07195	COG0189	ligase activity
NSED_RS07200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NSED_RS07205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NSED_RS07210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NSED_RS07230	COG0189	ligase activity
NSED_RS07245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NSED_RS07245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NSED_RS07260	COG0316	Belongs to the HesB IscA family
NSED_RS07265	COG0517	IMP dehydrogenase activity
NSED_RS07285	COG1024	Enoyl-CoA hydratase
NSED_RS07295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NSED_RS07295	COG0512	Glutamine amidotransferase of anthranilate synthase
NSED_RS07305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NSED_RS07320	COG2226	methyltransferase
NSED_RS07330	COG0347	Belongs to the P(II) protein family
NSED_RS07345	COG0513	Belongs to the DEAD box helicase family
NSED_RS07350	COG1028	Short-chain dehydrogenase reductase Sdr
NSED_RS07400	COG1301	dicarboxylic acid transport
NSED_RS07430	COG0405	Gamma-glutamyltransferase
NSED_RS07435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NSED_RS07440	COG0598	Magnesium transport protein CorA
NSED_RS07445	COG1181	Belongs to the D-alanine--D-alanine ligase family
NSED_RS07455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NSED_RS07455	COG3153	acetyltransferase
NSED_RS07490	COG0475	glutathione-regulated potassium exporter activity
NSED_RS07535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NSED_RS07540	COG0473	3-isopropylmalate dehydrogenase activity
NSED_RS07545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NSED_RS07550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NSED_RS07570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NSED_RS07590	COG0543	2 iron, 2 sulfur cluster binding
NSED_RS07595	COG0167	dihydroorotate dehydrogenase activity
NSED_RS07620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NSED_RS07625	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NSED_RS07655	COG0589	response to stress
NSED_RS07675	COG0832	Belongs to the urease beta subunit family
NSED_RS07680	COG0831	urea catabolic process
NSED_RS07690	COG0830	nickel cation binding
NSED_RS07700	COG0829	nickel cation binding
NSED_RS07730	COG1522	sequence-specific DNA binding
NSED_RS07805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NSED_RS07810	COG1051	belongs to the nudix hydrolase family
NSED_RS07815	COG0284	orotidine-5'-phosphate decarboxylase activity
NSED_RS07825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NSED_RS07835	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NSED_RS07855	COG0009	L-threonylcarbamoyladenylate synthase
NSED_RS07875	COG0084	hydrolase, TatD family'
NSED_RS07885	COG3794	PFAM blue (type 1) copper domain protein
NSED_RS07985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NSED_RS08000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NSED_RS08040	COG0517	IMP dehydrogenase activity
NSED_RS08050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NSED_RS08055	COG0367	asparagine synthase
NSED_RS08060	COG2154	pterin-4-alpha-carbinolamine dehydratase
NSED_RS08070	COG0525	valine-tRNA ligase activity
NSED_RS08125	COG1522	sequence-specific DNA binding
NSED_RS08155	COG1012	belongs to the aldehyde dehydrogenase family
NSED_RS08175	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NSED_RS08195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NSED_RS08220	COG0072	phenylalanine-tRNA ligase activity
NSED_RS08250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NSED_RS08250	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NSED_RS08360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NSED_RS08380	COG0714	Associated with various cellular activities
NSED_RS08435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NSED_RS08460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NSED_RS08475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NSED_RS08480	COG0012	GTP binding
NSED_RS08490	COG0343	queuine tRNA-ribosyltransferase activity
NSED_RS08505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NSED_RS08555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NSED_RS08560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NSED_RS08565	COG0463	Glycosyl transferase, family 2
NSED_RS08575	COG0347	Belongs to the P(II) protein family
NSED_RS08620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NSED_RS08640	COG1216	Glycosyl transferase, family 2
NSED_RS08640	COG1442	glycosyl transferase family 8
NSED_RS08645	COG0438	transferase activity, transferring glycosyl groups
NSED_RS08680	COG1607	acyl-coa hydrolase
NSED_RS08685	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NSED_RS08730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NSED_RS08745	COG1012	belongs to the aldehyde dehydrogenase family
NSED_RS08765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NSED_RS08770	COG0402	S-adenosylhomocysteine deaminase activity
NSED_RS08780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NSED_RS08785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NSED_RS08785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NSED_RS08790	COG0307	riboflavin synthase, alpha
NSED_RS08815	COG1063	alcohol dehydrogenase
NSED_RS08935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NSED_RS08985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NSED_RS08990	COG1121	(ABC) transporter
NSED_RS08995	COG0803	Belongs to the bacterial solute-binding protein 9 family
NSED_RS09000	COG0864	Transcriptional regulator
NSED_RS09020	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NSED_RS09030	COG1394	ATPase activity, coupled to movement of substances
NSED_RS09040	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
NSED_RS09050	COG1269	ATP hydrolysis coupled proton transport
NSED_RS09075	COG0004	ammonium transporteR
NSED_RS09110	COG0528	UMP kinase activity
NSED_RS09115	COG1078	dGTPase activity
NSED_RS09120	COG0563	adenylate kinase activity
NSED_RS09130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NSED_RS09155	COG1136	(ABC) transporter
NSED_RS09190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NSED_RS09195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NSED_RS09205	COG2226	methyltransferase
NSED_RS09215	COG0006	proline dipeptidase activity
NSED_RS09230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NSED_RS09240	COG0371	Dehydrogenase
NSED_RS09255	COG1056	cytidyltransferase-related domain
NSED_RS09255	COG1051	belongs to the nudix hydrolase family
NSED_RS09260	COG0430	RNA-3'-phosphate cyclase activity
NSED_RS09265	COG1276	copper resistance
NSED_RS09280	COG0778	Nitroreductase
NSED_RS09415	COG0714	Associated with various cellular activities
NSED_RS09435	COG1104	cysteine desulfurase activity
NSED_RS09465	COG0004	ammonium transporteR
NSED_RS09470	COG0347	Belongs to the P(II) protein family
NSED_RS09475	COG0347	Belongs to the P(II) protein family
NSED_RS09480	COG0484	heat shock protein binding
NSED_RS09500	COG0531	amino acid
NSED_RS09505	COG0475	glutathione-regulated potassium exporter activity
NSED_RS09520	COG1509	lysine 2,3-aminomutase activity
NSED_RS09530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NSED_RS09540	COG1234	tRNA 3'-trailer cleavage
NSED_RS09545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NSED_RS09590	COG0446	pyridine nucleotide-disulphide oxidoreductase
NSED_RS09595	COG4221	oxidoreductase activity
NSED_RS09615	COG0174	glutamine synthetase
NSED_RS09625	COG0459	protein refolding
NSED_RS09630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NSED_RS09640	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NSED_RS09700	COG1252	NADH dehydrogenase
NSED_RS09770	COG3263	regulation of cellular component size
NSED_RS09780	COG0529	Catalyzes the synthesis of activated sulfate
NSED_RS09835	COG0602	queuosine metabolic process
NSED_RS09840	COG0302	gtp cyclohydrolase
NSED_RS09850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NSED_RS09855	COG0083	homoserine kinase activity
NSED_RS09870	COG0300	oxidoreductase activity
NSED_RS09895	COG0175	sulfate reduction
NSED_RS09900	COG2046	Belongs to the sulfate adenylyltransferase family
NSED_RS09910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NSED_RS09965	COG0463	Glycosyl transferase, family 2
NSED_RS09975	COG0463	Glycosyl transferase, family 2
NSED_RS09985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NSED_RS10015	COG1442	glycosyl transferase family 8
NSED_RS10015	COG1216	Glycosyl transferase, family 2
NSED_RS10020	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NSED_RS10135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NSED_RS10180	COG0745	RESPONSE REGULATOR receiver