locus-tag	class	description
NTE_RS00040	COG4122	O-methyltransferase activity
NTE_RS00080	COG1058	Belongs to the CinA family
NTE_RS00080	COG1546	Belongs to the CinA family
NTE_RS00120	COG2130	NADP-dependent
NTE_RS00140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NTE_RS00155	COG1121	(ABC) transporter
NTE_RS00160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NTE_RS00170	COG0494	nUDIX hydrolase
NTE_RS00200	COG0704	Plays a role in the regulation of phosphate uptake
NTE_RS00205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NTE_RS00210	COG0581	inorganic phosphate transmembrane transporter activity
NTE_RS00240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NTE_RS00245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NTE_RS00260	COG1733	regulation of RNA biosynthetic process
NTE_RS00265	COG2226	methyltransferase
NTE_RS00270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NTE_RS00275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NTE_RS00345	COG0140	phosphoribosyl-ATP diphosphatase activity
NTE_RS00345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NTE_RS00350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NTE_RS00355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NTE_RS00370	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NTE_RS00450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NTE_RS00460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NTE_RS00465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NTE_RS00510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NTE_RS00535	COG0501	Belongs to the peptidase M48B family
NTE_RS00615	COG1335	isochorismatase
NTE_RS00620	COG1215	transferase activity, transferring glycosyl groups
NTE_RS00625	COG0438	transferase activity, transferring glycosyl groups
NTE_RS00695	COG1131	(ABC) transporter
NTE_RS00720	COG2204	response regulator
NTE_RS00740	COG2204	response regulator
NTE_RS00830	COG0745	RESPONSE REGULATOR receiver
NTE_RS00975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NTE_RS00980	COG2226	methyltransferase
NTE_RS00985	COG5002	protein histidine kinase activity
NTE_RS01000	COG3546	catalase activity
NTE_RS01105	COG4106	trans-aconitate 2-methyltransferase activity
NTE_RS01190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NTE_RS01240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NTE_RS01275	COG1475	DNA binding
NTE_RS01280	COG1215	transferase activity, transferring glycosyl groups
NTE_RS01370	COG1994	Peptidase M50
NTE_RS01370	COG0517	IMP dehydrogenase activity
NTE_RS01400	COG5002	protein histidine kinase activity
NTE_RS01445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NTE_RS01515	COG0745	RESPONSE REGULATOR receiver
NTE_RS01530	COG5002	protein histidine kinase activity
NTE_RS01540	COG2124	cytochrome p450
NTE_RS01590	COG4651	solute:proton antiporter activity
NTE_RS01590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NTE_RS01635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NTE_RS01705	COG0484	heat shock protein binding
NTE_RS01730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NTE_RS01775	COG4221	oxidoreductase activity
NTE_RS01780	COG1252	NADH dehydrogenase
NTE_RS01790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NTE_RS01790	COG1796	DNA polymerase
NTE_RS01820	COG2267	carboxylic ester hydrolase activity
NTE_RS01825	COG0308	aminopeptidase N
NTE_RS01830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NTE_RS01840	COG0640	Transcriptional regulator
NTE_RS01855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NTE_RS01945	COG5002	protein histidine kinase activity
NTE_RS01955	COG2326	polyphosphate kinase activity
NTE_RS02030	COG1475	DNA binding
NTE_RS02095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NTE_RS02185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NTE_RS02210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NTE_RS02220	COG0459	protein refolding
NTE_RS02225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NTE_RS02230	COG0589	response to stress
NTE_RS02260	COG2070	2-Nitropropane dioxygenase
NTE_RS02275	COG1053	succinate dehydrogenase
NTE_RS02305	COG2133	pyrroloquinoline quinone binding
NTE_RS02310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NTE_RS02315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NTE_RS02330	COG0517	IMP dehydrogenase activity
NTE_RS02330	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NTE_RS02420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NTE_RS02450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NTE_RS02450	COG4451	ribulose bisphosphate carboxylase, small
NTE_RS02455	COG0515	serine threonine protein kinase
NTE_RS02455	COG2815	serine threonine protein kinase
NTE_RS02505	COG2514	catechol 2,3-dioxygenase activity
NTE_RS02535	COG0714	Associated with various cellular activities
NTE_RS02545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NTE_RS02550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NTE_RS02555	COG3959	Transketolase, thiamine diphosphate binding domain
NTE_RS02565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NTE_RS02580	COG1129	ABC transporter
NTE_RS02620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NTE_RS02625	COG1704	LemA family
NTE_RS02695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NTE_RS02695	COG1017	nitric oxide dioxygenase activity
NTE_RS02710	COG1185	polyribonucleotide nucleotidyltransferase activity
NTE_RS02720	COG0163	prenyltransferase activity
NTE_RS02730	COG2329	Antibiotic biosynthesis monooxygenase
NTE_RS02755	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NTE_RS02785	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NTE_RS02795	COG1051	belongs to the nudix hydrolase family
NTE_RS02800	COG0284	orotidine-5'-phosphate decarboxylase activity
NTE_RS02815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NTE_RS02825	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NTE_RS02885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NTE_RS02915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NTE_RS02920	COG0010	Belongs to the arginase family
NTE_RS02925	COG0417	DNA replication proofreading
NTE_RS02970	COG0419	ATPase involved in DNA repair
NTE_RS03035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NTE_RS03050	COG0081	regulation of translation
NTE_RS03145	COG0137	argininosuccinate synthase activity
NTE_RS03155	COG0189	ligase activity
NTE_RS03160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NTE_RS03170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NTE_RS03200	COG0778	Nitroreductase
NTE_RS03200	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NTE_RS03240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NTE_RS03280	COG1027	Aspartate ammonia-lyase
NTE_RS03290	COG3189	MarR family transcriptional regulator
NTE_RS03300	COG0508	dehydrogenase complex catalyzes the overall conversion of
NTE_RS03300	COG0596	Alpha beta hydrolase
NTE_RS03305	COG1012	belongs to the aldehyde dehydrogenase family
NTE_RS03315	COG0113	porphobilinogen synthase activity
NTE_RS03320	COG0598	Magnesium transport protein CorA
NTE_RS03335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NTE_RS03355	COG4608	Belongs to the ABC transporter superfamily
NTE_RS03365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NTE_RS03410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NTE_RS03420	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NTE_RS03425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NTE_RS03435	COG0154	amidase activity
NTE_RS03440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NTE_RS03460	COG0179	Fumarylacetoacetate (FAA) hydrolase
NTE_RS03475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NTE_RS03530	COG0300	oxidoreductase activity
NTE_RS03550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NTE_RS03555	COG3830	Belongs to the UPF0237 family
NTE_RS03555	COG0560	Phosphoserine phosphatase
NTE_RS03575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NTE_RS03580	COG0805	protein transport
NTE_RS03605	COG1733	regulation of RNA biosynthetic process
NTE_RS03620	COG0778	Nitroreductase
NTE_RS03660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NTE_RS03665	COG1335	isochorismatase
NTE_RS03695	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NTE_RS03700	COG0745	RESPONSE REGULATOR receiver
NTE_RS03705	COG5002	protein histidine kinase activity
NTE_RS03710	COG0531	amino acid
NTE_RS03720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NTE_RS03735	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NTE_RS03770	COG0306	phosphate transporter
NTE_RS03835	COG0589	response to stress
NTE_RS03895	COG0589	response to stress
NTE_RS03900	COG0516	GMP reductase activity
NTE_RS03900	COG0517	IMP dehydrogenase activity
NTE_RS03925	COG0517	IMP dehydrogenase activity
NTE_RS03950	COG0589	response to stress
NTE_RS04050	COG1136	(ABC) transporter
NTE_RS04060	COG1136	(ABC) transporter
NTE_RS04060	COG0577	efflux transmembrane transporter activity
NTE_RS04070	COG0527	aspartate kinase activity
NTE_RS04070	COG0460	homoserine dehydrogenase
NTE_RS04080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NTE_RS04110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NTE_RS04115	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NTE_RS04120	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NTE_RS04125	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NTE_RS04150	COG0477	Major facilitator Superfamily
NTE_RS04225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NTE_RS04230	COG2151	metal-sulfur cluster biosynthetic enzyme
NTE_RS04285	COG0436	Aminotransferase
NTE_RS04320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NTE_RS04340	COG1454	alcohol dehydrogenase
NTE_RS04365	COG1309	transcriptional regulator
NTE_RS04405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NTE_RS04405	COG1648	precorrin-2 dehydrogenase activity
NTE_RS04410	COG0181	hydroxymethylbilane synthase activity
NTE_RS04415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NTE_RS04435	COG0585	pseudouridine synthase activity
NTE_RS04475	COG0528	UMP kinase activity
NTE_RS04480	COG1078	dGTPase activity
NTE_RS04485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NTE_RS04505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NTE_RS04515	COG0494	nUDIX hydrolase
NTE_RS04530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NTE_RS04575	COG1942	4-Oxalocrotonate Tautomerase
NTE_RS04585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NTE_RS04620	COG1131	(ABC) transporter
NTE_RS04630	COG1201	RNA secondary structure unwinding
NTE_RS04685	COG0667	Aldo Keto reductase
NTE_RS04740	COG0167	dihydroorotate dehydrogenase activity
NTE_RS04755	COG1418	mRNA catabolic process
NTE_RS04765	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NTE_RS04790	COG2890	protein-(glutamine-N5) methyltransferase activity
NTE_RS04805	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NTE_RS04815	COG1136	(ABC) transporter
NTE_RS04815	COG0577	efflux transmembrane transporter activity
NTE_RS04825	COG1136	(ABC) transporter
NTE_RS04845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NTE_RS04845	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NTE_RS04860	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NTE_RS04860	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NTE_RS04865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NTE_RS04870	COG0589	response to stress
NTE_RS04910	COG0783	Belongs to the Dps family
NTE_RS05010	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NTE_RS05020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NTE_RS05020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NTE_RS05025	COG0450	alkyl hydroperoxide reductase
NTE_RS05030	COG1028	Short-chain dehydrogenase reductase Sdr
NTE_RS05040	COG0346	lactoylglutathione lyase activity
NTE_RS05045	COG0400	carboxylic ester hydrolase activity
NTE_RS05075	COG2140	Oxalate decarboxylase
NTE_RS05095	COG0347	Belongs to the P(II) protein family
NTE_RS05110	COG2814	Major facilitator Superfamily
NTE_RS05120	COG1012	belongs to the aldehyde dehydrogenase family
NTE_RS05160	COG1475	DNA binding
NTE_RS05190	COG1475	DNA binding
NTE_RS05210	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
NTE_RS05240	COG0459	protein refolding
NTE_RS05260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NTE_RS05265	COG1404	Belongs to the peptidase S8 family
NTE_RS05275	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NTE_RS05280	COG0105	UTP biosynthetic process
NTE_RS05385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NTE_RS05400	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NTE_RS05410	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NTE_RS05425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NTE_RS05440	COG1013	pyruvate-flavodoxin oxidoreductase activity
NTE_RS05480	COG0396	ATPase activity
NTE_RS05485	COG3253	May function as heme-dependent peroxidase
NTE_RS05495	COG0667	Aldo Keto reductase
NTE_RS05500	COG1522	sequence-specific DNA binding
NTE_RS05530	COG0066	3-isopropylmalate dehydratase activity
NTE_RS05535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NTE_RS05540	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
NTE_RS05540	COG0778	Nitroreductase
NTE_RS05595	COG2340	Cysteine-rich secretory protein family
NTE_RS05635	COG1522	sequence-specific DNA binding
NTE_RS05650	COG3118	belongs to the thioredoxin family
NTE_RS05660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NTE_RS05665	COG0495	leucyl-tRNA aminoacylation
NTE_RS05705	COG0552	protein localization to endoplasmic reticulum
NTE_RS05710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NTE_RS05750	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NTE_RS05820	COG3425	synthase
NTE_RS05825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NTE_RS05835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NTE_RS05835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NTE_RS05880	COG0668	transmembrane transport
NTE_RS05900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NTE_RS05905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NTE_RS05925	COG2169	Transcriptional regulator
NTE_RS05925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NTE_RS05935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NTE_RS05940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NTE_RS05960	COG0322	excinuclease ABC activity
NTE_RS05975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NTE_RS05980	COG2897	thiosulfate sulfurtransferase activity
NTE_RS05995	COG1215	transferase activity, transferring glycosyl groups
NTE_RS06115	COG0113	porphobilinogen synthase activity
NTE_RS06120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NTE_RS06125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NTE_RS06125	COG1648	precorrin-2 dehydrogenase activity
NTE_RS06140	COG3695	enzyme binding
NTE_RS06165	COG1234	tRNA 3'-trailer cleavage
NTE_RS06230	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NTE_RS06230	COG0493	'glutamate synthase
NTE_RS06265	COG0371	Dehydrogenase
NTE_RS06275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NTE_RS06285	COG0482	sulfurtransferase activity
NTE_RS06290	COG0072	phenylalanine-tRNA ligase activity
NTE_RS06330	COG0028	Belongs to the TPP enzyme family
NTE_RS06400	COG5002	protein histidine kinase activity
NTE_RS06440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NTE_RS06510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NTE_RS06550	COG0642	Histidine kinase
NTE_RS06575	COG1970	mechanosensitive ion channel activity
NTE_RS06630	COG0745	RESPONSE REGULATOR receiver
NTE_RS06640	COG0745	RESPONSE REGULATOR receiver
NTE_RS06645	COG0745	RESPONSE REGULATOR receiver
NTE_RS06670	COG0281	malic enzyme
NTE_RS06735	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NTE_RS06765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NTE_RS06770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NTE_RS06775	COG1960	acyl-CoA dehydrogenase activity
NTE_RS06840	COG1309	transcriptional regulator
NTE_RS06880	COG3794	PFAM blue (type 1) copper domain protein
NTE_RS06915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NTE_RS06920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NTE_RS06925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NTE_RS06935	COG2094	Belongs to the DNA glycosylase MPG family
NTE_RS06940	COG1573	uracil-dna glycosylase
NTE_RS06955	COG0004	ammonium transporteR
NTE_RS06965	COG4651	solute:proton antiporter activity
NTE_RS06965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NTE_RS06985	COG2267	carboxylic ester hydrolase activity
NTE_RS07015	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NTE_RS07035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NTE_RS07040	COG0189	ligase activity
NTE_RS07050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NTE_RS07055	COG0165	Argininosuccinate lyase
NTE_RS07145	COG0071	Belongs to the small heat shock protein (HSP20) family
NTE_RS07165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NTE_RS07245	COG3243	poly(R)-hydroxyalkanoic acid synthase
NTE_RS07270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NTE_RS07270	COG0519	Catalyzes the synthesis of GMP from XMP
NTE_RS07290	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NTE_RS07290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NTE_RS07310	COG0442	prolyl-tRNA aminoacylation
NTE_RS07330	COG1260	myo-inositol-1-phosphate synthase
NTE_RS07340	COG0215	cysteine-tRNA ligase activity
NTE_RS07345	COG0535	radical SAM domain protein
NTE_RS07410	COG0109	protoheme IX farnesyltransferase activity
NTE_RS07430	COG0017	Asparaginyl-tRNA synthetase
NTE_RS07465	COG0444	Belongs to the ABC transporter superfamily
NTE_RS07485	COG0126	phosphoglycerate kinase activity
NTE_RS07530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NTE_RS07535	COG0517	IMP dehydrogenase activity
NTE_RS07555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NTE_RS07560	COG3794	PFAM blue (type 1) copper domain protein
NTE_RS07565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NTE_RS07570	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
NTE_RS07590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NTE_RS07595	COG0157	Belongs to the NadC ModD family
NTE_RS07605	COG1185	polyribonucleotide nucleotidyltransferase activity
NTE_RS07610	COG0489	protein tyrosine kinase activity
NTE_RS07630	COG0277	FAD linked oxidase domain protein
NTE_RS07635	COG4106	trans-aconitate 2-methyltransferase activity
NTE_RS07650	COG2226	methyltransferase
NTE_RS07690	COG0463	Glycosyl transferase, family 2
NTE_RS07705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NTE_RS07715	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
NTE_RS07745	COG1797	cobyrinic acid a,c-diamide synthase activity
NTE_RS07820	COG2078	PFAM AMMECR1 domain protein
NTE_RS07825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NTE_RS07860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NTE_RS07885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NTE_RS07915	COG0537	adenosine 5'-monophosphoramidase activity
NTE_RS07930	COG0582	viral genome integration into host DNA
NTE_RS08010	COG0156	8-amino-7-oxononanoate synthase activity
NTE_RS08015	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NTE_RS08020	COG4766	ethanolamine catabolic process
NTE_RS08095	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NTE_RS08100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NTE_RS08105	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NTE_RS08125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NTE_RS08130	COG0183	Belongs to the thiolase family
NTE_RS08155	COG5002	protein histidine kinase activity
NTE_RS08160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NTE_RS08165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NTE_RS08175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NTE_RS08190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NTE_RS08195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NTE_RS08210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NTE_RS08215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NTE_RS08220	COG0089	rRNA binding
NTE_RS08230	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NTE_RS08245	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NTE_RS08270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NTE_RS08275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NTE_RS08305	COG0730	response to heat
NTE_RS08315	COG0460	homoserine dehydrogenase
NTE_RS08510	COG0512	Glutamine amidotransferase of anthranilate synthase
NTE_RS08510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NTE_RS08515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NTE_RS08535	COG0159	tryptophan synthase activity
NTE_RS08540	COG0133	tryptophan synthase activity
NTE_RS08545	COG0134	indole-3-glycerol-phosphate synthase activity
NTE_RS08570	COG0504	CTP synthase activity
NTE_RS08575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NTE_RS08590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NTE_RS08605	COG2202	Pas domain
NTE_RS08605	COG2205	protein histidine kinase activity
NTE_RS08615	COG1028	Short-chain dehydrogenase reductase Sdr
NTE_RS08635	COG2133	pyrroloquinoline quinone binding
NTE_RS08715	COG0436	Aminotransferase
NTE_RS08725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NTE_RS08735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NTE_RS08740	COG0710	3-dehydroquinate dehydratase activity
NTE_RS08765	COG1465	3-dehydroquinate synthase
NTE_RS08770	COG1830	Aldolase
NTE_RS08785	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NTE_RS08800	COG1615	UPF0182 protein
NTE_RS08850	COG0475	glutathione-regulated potassium exporter activity
NTE_RS08875	COG2379	hydroxypyruvate reductase
NTE_RS08880	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NTE_RS08880	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NTE_RS08890	COG0012	GTP binding
NTE_RS08910	COG1832	CoA-binding protein
NTE_RS08935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NTE_RS08945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NTE_RS08945	COG0517	IMP dehydrogenase activity
NTE_RS08945	COG0617	tRNA 3'-terminal CCA addition
NTE_RS09020	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NTE_RS09045	COG0589	response to stress
NTE_RS09100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NTE_RS09130	COG0351	phosphomethylpyrimidine kinase
NTE_RS09135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NTE_RS09180	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
NTE_RS09315	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NTE_RS09480	COG1744	ABC transporter substrate-binding protein PnrA-like
NTE_RS09485	COG0642	Histidine kinase
NTE_RS09555	COG1945	arginine decarboxylase activity
NTE_RS09645	COG0788	formyltetrahydrofolate deformylase activity
NTE_RS09685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NTE_RS09690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NTE_RS09710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NTE_RS09715	COG0505	Belongs to the CarA family
NTE_RS09725	COG0473	3-isopropylmalate dehydrogenase activity
NTE_RS09730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NTE_RS09735	COG0440	acetolactate synthase activity
NTE_RS09740	COG0028	Belongs to the TPP enzyme family
NTE_RS09755	COG1063	alcohol dehydrogenase
NTE_RS09820	COG1793	dna ligase
NTE_RS09845	COG1017	nitric oxide dioxygenase activity
NTE_RS09845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NTE_RS09870	COG2217	Heavy metal translocating P-type atpase
NTE_RS09885	COG0010	Belongs to the arginase family
NTE_RS09890	COG1024	Enoyl-CoA hydratase
NTE_RS09895	COG0083	homoserine kinase activity
NTE_RS09950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NTE_RS09960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NTE_RS09965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NTE_RS09995	COG0560	Phosphoserine phosphatase
NTE_RS10010	COG2267	carboxylic ester hydrolase activity
NTE_RS10020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NTE_RS10030	COG0492	ferredoxin-NADP+ reductase activity
NTE_RS10060	COG0535	radical SAM domain protein
NTE_RS10070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NTE_RS10125	COG1304	FMN binding
NTE_RS10130	COG0142	geranyltranstransferase activity
NTE_RS10140	COG0179	Fumarylacetoacetate (FAA) hydrolase
NTE_RS10150	COG0431	NADPH-dependent FMN reductase
NTE_RS10210	COG2226	methyltransferase
NTE_RS10255	COG0024	Methionine aminopeptidase
NTE_RS10275	COG1321	iron dependent repressor
NTE_RS10340	COG0673	inositol 2-dehydrogenase activity
NTE_RS10350	COG0110	maltose O-acetyltransferase activity
NTE_RS10400	COG1378	Sugar-specific transcriptional regulator TrmB
NTE_RS10405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NTE_RS10435	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
NTE_RS10440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NTE_RS10445	COG0066	3-isopropylmalate dehydratase activity
NTE_RS10480	COG5002	protein histidine kinase activity
NTE_RS10510	COG0840	transmembrane signaling receptor activity
NTE_RS10535	COG0835	chemotaxis
NTE_RS10540	COG2201	protein-glutamate methylesterase activity
NTE_RS10545	COG2201	protein-glutamate methylesterase activity
NTE_RS10550	COG0643	Histidine kinase
NTE_RS10550	COG2198	Histidine kinase
NTE_RS10555	COG1776	CheC inhibitor of MCP methylation
NTE_RS10560	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NTE_RS10625	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
NTE_RS10660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NTE_RS10700	COG0009	L-threonylcarbamoyladenylate synthase
NTE_RS10735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NTE_RS10775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NTE_RS10795	COG1215	transferase activity, transferring glycosyl groups
NTE_RS10820	COG1331	Highly conserved protein containing a thioredoxin domain
NTE_RS10860	COG0671	phosphoesterase, PA-phosphatase related
NTE_RS10880	COG0475	glutathione-regulated potassium exporter activity
NTE_RS10895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NTE_RS10900	COG1993	acr, cog1993
NTE_RS11000	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NTE_RS11005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NTE_RS11015	COG0651	ATP synthesis coupled electron transport
NTE_RS11020	COG0650	Formate hydrogenlyase subunit 4
NTE_RS11030	COG0651	ATP synthesis coupled electron transport
NTE_RS11035	COG3261	NADH dehydrogenase
NTE_RS11035	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
NTE_RS11040	COG3260	NADH ubiquinone oxidoreductase 20
NTE_RS11060	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NTE_RS11075	COG1250	3-hydroxyacyl-CoA dehydrogenase
NTE_RS11100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NTE_RS11125	COG0644	oxidoreductase
NTE_RS11140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NTE_RS11160	COG0367	asparagine synthase
NTE_RS11165	COG0556	nucleotide-excision repair
NTE_RS11170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NTE_RS11175	COG0322	excinuclease ABC activity
NTE_RS11190	COG0686	Belongs to the AlaDH PNT family
NTE_RS11260	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NTE_RS11265	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NTE_RS11280	COG1215	transferase activity, transferring glycosyl groups
NTE_RS11370	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
NTE_RS11445	COG0142	geranyltranstransferase activity
NTE_RS11455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NTE_RS11460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NTE_RS11465	COG0713	ATP synthesis coupled electron transport
NTE_RS11475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NTE_RS11480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NTE_RS11485	COG0649	NAD binding
NTE_RS11490	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NTE_RS11495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NTE_RS11595	COG0644	oxidoreductase
NTE_RS11600	COG0312	modulator of DNA gyrase
NTE_RS11620	COG0300	oxidoreductase activity
NTE_RS11630	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NTE_RS11655	COG0148	phosphopyruvate hydratase activity
NTE_RS11665	COG0052	Belongs to the universal ribosomal protein uS2 family
NTE_RS11675	COG1355	regulation of microtubule-based process
NTE_RS11700	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NTE_RS11720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NTE_RS11725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NTE_RS11730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NTE_RS11805	COG1047	Peptidyl-prolyl cis-trans
NTE_RS11810	COG0316	Belongs to the HesB IscA family
NTE_RS11825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NTE_RS11850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NTE_RS11855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NTE_RS11890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NTE_RS11890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NTE_RS11895	COG0300	oxidoreductase activity
NTE_RS11900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NTE_RS11900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NTE_RS11910	COG2084	Dehydrogenase
NTE_RS11935	COG0719	Fe-S assembly protein
NTE_RS11940	COG0719	Fe-S assembly protein
NTE_RS11945	COG0723	plastoquinol--plastocyanin reductase activity
NTE_RS11950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NTE_RS11955	COG0822	iron-sulfur transferase activity
NTE_RS11965	COG0671	phosphoesterase, PA-phosphatase related
NTE_RS11980	COG1011	Hydrolase
NTE_RS12000	COG0175	sulfate reduction
NTE_RS12005	COG2046	Belongs to the sulfate adenylyltransferase family
NTE_RS12060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NTE_RS12095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NTE_RS12115	COG0037	tRNA processing
NTE_RS12155	COG2217	Heavy metal translocating P-type atpase
NTE_RS12205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NTE_RS12240	COG1733	regulation of RNA biosynthetic process
NTE_RS12260	COG0430	RNA-3'-phosphate cyclase activity
NTE_RS12265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NTE_RS12270	COG1056	cytidyltransferase-related domain
NTE_RS12270	COG1051	belongs to the nudix hydrolase family
NTE_RS12285	COG0252	asparaginase activity
NTE_RS12290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NTE_RS12340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NTE_RS12365	COG2255	four-way junction helicase activity
NTE_RS12400	COG0049	tRNA binding
NTE_RS12410	COG0195	Participates in both transcription termination and antitermination
NTE_RS12420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NTE_RS12425	COG0085	RNA polymerase activity
NTE_RS12455	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NTE_RS12470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NTE_RS12475	COG0012	GTP binding
NTE_RS12485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NTE_RS12535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NTE_RS12540	COG0439	Biotin carboxylase
NTE_RS12545	COG4770	biotin carboxylase activity
NTE_RS12565	COG1104	cysteine desulfurase activity
NTE_RS12570	COG1606	tRNA processing
NTE_RS12575	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
NTE_RS12645	COG0200	Binds to the 23S rRNA
NTE_RS12655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NTE_RS12660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NTE_RS12665	COG1691	(AIR) carboxylase
NTE_RS12670	COG0039	L-malate dehydrogenase activity
NTE_RS12690	COG2096	Adenosyltransferase
NTE_RS12715	COG0330	HflC and HflK could
NTE_RS12720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NTE_RS12740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NTE_RS12745	COG0154	amidase activity
NTE_RS12750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NTE_RS12755	COG0017	Asparaginyl-tRNA synthetase
NTE_RS12810	COG1028	Short-chain dehydrogenase reductase Sdr
NTE_RS12915	COG0051	transcription antitermination factor activity, RNA binding
NTE_RS12920	COG2895	sulfate adenylyltransferase (ATP) activity
NTE_RS12920	COG0529	Catalyzes the synthesis of activated sulfate
NTE_RS12925	COG1980	fructose-bisphosphate aldolase activity
NTE_RS12935	COG4106	trans-aconitate 2-methyltransferase activity
NTE_RS12940	COG2860	membrane
NTE_RS12945	COG0574	Belongs to the PEP-utilizing enzyme family
NTE_RS12945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NTE_RS12950	COG0477	Major facilitator Superfamily
NTE_RS12955	COG2226	methyltransferase
NTE_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
NTE_RS13030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NTE_RS13035	COG1993	acr, cog1993
NTE_RS13050	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NTE_RS13055	COG0830	nickel cation binding
NTE_RS13070	COG0459	protein refolding
NTE_RS13075	COG0804	urea catabolic process
NTE_RS13085	COG0831	urea catabolic process
NTE_RS13095	COG4413	Urea transporter
NTE_RS13105	COG1522	sequence-specific DNA binding
NTE_RS13110	COG1475	DNA binding
NTE_RS13120	COG0589	response to stress
NTE_RS13150	COG1475	DNA binding
NTE_RS13155	COG0010	Belongs to the arginase family
NTE_RS13160	COG0831	urea catabolic process
NTE_RS13165	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
NTE_RS13170	COG0864	Transcriptional regulator
NTE_RS13180	COG0831	urea catabolic process
NTE_RS13185	COG0831	urea catabolic process
NTE_RS13185	COG0832	Belongs to the urease beta subunit family
NTE_RS13205	COG0372	Belongs to the citrate synthase family
NTE_RS13220	COG1793	dna ligase
NTE_RS13220	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NTE_RS13225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NTE_RS13235	COG2226	methyltransferase
NTE_RS13240	COG0513	Belongs to the DEAD box helicase family
NTE_RS13275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NTE_RS13320	COG2205	protein histidine kinase activity
NTE_RS13320	COG0784	Response regulator, receiver
NTE_RS13325	COG0745	RESPONSE REGULATOR receiver
NTE_RS13340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NTE_RS13380	COG2095	MarC family integral membrane protein
NTE_RS13425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NTE_RS13435	COG0494	nUDIX hydrolase
NTE_RS13465	COG0017	Asparaginyl-tRNA synthetase
NTE_RS13480	COG0646	methionine synthase
NTE_RS13480	COG1410	methionine synthase
NTE_RS13495	COG2154	pterin-4-alpha-carbinolamine dehydratase
NTE_RS13510	COG0646	methionine synthase
NTE_RS13510	COG1410	methionine synthase
NTE_RS13605	COG0589	response to stress
NTE_RS13615	COG0494	nUDIX hydrolase
NTE_RS13660	COG0018	arginyl-trna synthetase
NTE_RS13670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NTE_RS13680	COG1222	aaa ATPase
NTE_RS13705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NTE_RS13760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NTE_RS13765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NTE_RS13770	COG0483	inositol monophosphate 1-phosphatase activity
NTE_RS13785	COG1899	peptidyl-lysine modification to peptidyl-hypusine
NTE_RS13825	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NTE_RS13835	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NTE_RS13880	COG2267	carboxylic ester hydrolase activity
NTE_RS14000	COG3360	Dodecin
NTE_RS14085	COG0109	protoheme IX farnesyltransferase activity
NTE_RS14090	COG1522	sequence-specific DNA binding
NTE_RS14100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NTE_RS14105	COG1492	cobalamin metabolic process
NTE_RS14145	COG0459	protein refolding
NTE_RS14175	COG0412	Dienelactone hydrolase
NTE_RS14180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NTE_RS14185	COG1116	anion transmembrane transporter activity
NTE_RS14245	COG0604	alcohol dehydrogenase
NTE_RS14270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NTE_RS14275	COG3118	belongs to the thioredoxin family
NTE_RS14300	COG1215	transferase activity, transferring glycosyl groups
NTE_RS14305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NTE_RS14310	COG1442	glycosyl transferase family 8
NTE_RS14310	COG1216	Glycosyl transferase, family 2
NTE_RS14320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NTE_RS14325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NTE_RS14330	COG0004	ammonium transporteR
NTE_RS14335	COG0003	Pfam Anion-transporting ATPase
NTE_RS14450	COG2133	pyrroloquinoline quinone binding
NTE_RS14460	COG0300	oxidoreductase activity
NTE_RS14465	COG0477	Major facilitator Superfamily
NTE_RS14490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NTE_RS14495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NTE_RS14520	COG0131	Imidazoleglycerol-phosphate dehydratase
NTE_RS14525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NTE_RS14530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NTE_RS14545	COG1254	Belongs to the acylphosphatase family
NTE_RS14550	COG0019	diaminopimelate decarboxylase activity
NTE_RS14555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NTE_RS14565	COG0077	Prephenate dehydratase
NTE_RS14565	COG1605	Chorismate mutase
NTE_RS14575	COG0517	IMP dehydrogenase activity
NTE_RS14575	COG0516	GMP reductase activity
NTE_RS14580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NTE_RS14610	COG0519	Catalyzes the synthesis of GMP from XMP
NTE_RS14610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NTE_RS14615	COG2226	methyltransferase
NTE_RS14665	COG3794	PFAM blue (type 1) copper domain protein
NTE_RS14735	COG1132	(ABC) transporter
NTE_RS14740	COG2866	Carboxypeptidase
NTE_RS14875	COG1269	ATP hydrolysis coupled proton transport
NTE_RS14885	COG1394	ATPase activity, coupled to movement of substances
NTE_RS14890	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
NTE_RS14895	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
NTE_RS14945	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
NTE_RS14960	COG0785	Cytochrome C biogenesis protein
NTE_RS14975	COG0489	protein tyrosine kinase activity
NTE_RS15025	COG0343	queuine tRNA-ribosyltransferase activity
NTE_RS15030	COG1515	deoxyribonuclease V activity
NTE_RS15065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NTE_RS15080	COG0215	cysteine-tRNA ligase activity
NTE_RS15095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NTE_RS15100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NTE_RS15130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NTE_RS15160	COG1733	regulation of RNA biosynthetic process
NTE_RS15195	COG0004	ammonium transporteR
NTE_RS15230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NTE_RS15515	COG3189	MarR family transcriptional regulator
NTE_RS15615	COG1012	belongs to the aldehyde dehydrogenase family
NTE_RS15645	COG1017	nitric oxide dioxygenase activity
NTE_RS15645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NTE_RS15650	COG0517	IMP dehydrogenase activity
NTE_RS15655	COG1733	regulation of RNA biosynthetic process
NTE_RS15670	COG2267	carboxylic ester hydrolase activity
NTE_RS15680	COG0475	glutathione-regulated potassium exporter activity
NTE_RS15700	COG0589	response to stress
NTE_RS15750	COG0367	asparagine synthase
NTE_RS15770	COG0668	transmembrane transport
NTE_RS15780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NTE_RS15790	COG0475	glutathione-regulated potassium exporter activity
NTE_RS15820	COG0589	response to stress
NTE_RS15865	COG0475	glutathione-regulated potassium exporter activity
NTE_RS15905	COG0471	metal ion transport
NTE_RS15910	COG0589	response to stress
NTE_RS15945	COG0589	response to stress
NTE_RS15950	COG1742	UPF0060 membrane protein
NTE_RS15965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NTE_RS16010	COG0506	proline dehydrogenase activity
NTE_RS16015	COG1012	belongs to the aldehyde dehydrogenase family
NTE_RS16050	COG0402	S-adenosylhomocysteine deaminase activity
NTE_RS16060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NTE_RS16065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NTE_RS16065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NTE_RS16070	COG0307	riboflavin synthase, alpha
NTE_RS16080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism