locus-tag	class	description
SAR11_RS00010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SAR11_RS00015	COG0440	acetolactate synthase activity
SAR11_RS00020	COG0028	Belongs to the TPP enzyme family
SAR11_RS00025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SAR11_RS00030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAR11_RS00040	COG0330	HflC and HflK could
SAR11_RS00045	COG0330	HflC and HflK could
SAR11_RS00050	COG0489	protein tyrosine kinase activity
SAR11_RS00055	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SAR11_RS00085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAR11_RS00090	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAR11_RS00100	COG0849	cell division
SAR11_RS00110	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAR11_RS00115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SAR11_RS00120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SAR11_RS00125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SAR11_RS00135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SAR11_RS00140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAR11_RS00145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SAR11_RS00160	COG0275	rRNA processing
SAR11_RS00170	COG2001	Belongs to the MraZ family
SAR11_RS00180	COG2853	Lipoprotein
SAR11_RS00200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAR11_RS00205	COG0358	DNA primase activity
SAR11_RS00215	COG0505	Belongs to the CarA family
SAR11_RS00220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SAR11_RS00255	COG0004	ammonium transporteR
SAR11_RS00260	COG0004	ammonium transporteR
SAR11_RS00285	COG1366	Belongs to the anti-sigma-factor antagonist family
SAR11_RS00290	COG1366	Belongs to the anti-sigma-factor antagonist family
SAR11_RS00305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SAR11_RS00335	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SAR11_RS00390	COG3660	Nucleoside-diphosphate-sugar epimerase
SAR11_RS00395	COG0492	ferredoxin-NADP+ reductase activity
SAR11_RS00410	COG0436	Aminotransferase
SAR11_RS00415	COG0556	nucleotide-excision repair
SAR11_RS00420	COG1028	Short-chain dehydrogenase reductase Sdr
SAR11_RS00430	COG0322	excinuclease ABC activity
SAR11_RS00435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SAR11_RS00440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SAR11_RS00450	COG0745	RESPONSE REGULATOR receiver
SAR11_RS00465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SAR11_RS00480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAR11_RS00485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SAR11_RS00490	COG0193	aminoacyl-tRNA hydrolase activity
SAR11_RS00495	COG0012	GTP binding
SAR11_RS00500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SAR11_RS00500	COG2857	Cytochrome c1
SAR11_RS00515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SAR11_RS00520	COG0408	coproporphyrinogen oxidase activity
SAR11_RS00525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SAR11_RS00530	COG0617	tRNA 3'-terminal CCA addition
SAR11_RS00540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SAR11_RS00550	COG1573	uracil-dna glycosylase
SAR11_RS00555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SAR11_RS00570	COG1194	a g-specific adenine glycosylase
SAR11_RS00580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SAR11_RS00585	COG1196	nuclear chromosome segregation
SAR11_RS00595	COG0356	it plays a direct role in the translocation of protons across the membrane
SAR11_RS00600	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAR11_RS00605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SAR11_RS00610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SAR11_RS00635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SAR11_RS00640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SAR11_RS00650	COG0678	peroxiredoxin activity
SAR11_RS00670	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
SAR11_RS00680	COG0109	protoheme IX farnesyltransferase activity
SAR11_RS00685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SAR11_RS00690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SAR11_RS00705	COG1733	regulation of RNA biosynthetic process
SAR11_RS00715	COG2259	Doxx family
SAR11_RS00725	COG1741	Belongs to the pirin family
SAR11_RS00740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SAR11_RS00745	COG1132	(ABC) transporter
SAR11_RS00755	COG1663	tetraacyldisaccharide 4'-kinase activity
SAR11_RS00770	COG0151	Belongs to the GarS family
SAR11_RS00775	COG0742	ribosomal rna small subunit methyltransferase
SAR11_RS00780	COG0166	Belongs to the GPI family
SAR11_RS00790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SAR11_RS00795	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SAR11_RS00800	COG0196	riboflavin kinase activity
SAR11_RS00810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SAR11_RS00815	COG0459	protein refolding
SAR11_RS00825	COG1217	gtp-binding protein TYPA
SAR11_RS00830	COG2364	Membrane
SAR11_RS00845	COG0312	modulator of DNA gyrase
SAR11_RS00850	COG0312	modulator of DNA gyrase
SAR11_RS00875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAR11_RS00910	COG2252	PERMEase
SAR11_RS00935	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAR11_RS00950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SAR11_RS00965	COG0588	phosphoglycerate mutase activity
SAR11_RS00970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SAR11_RS00980	COG0802	atpase or kinase
SAR11_RS00985	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SAR11_RS00990	COG2205	protein histidine kinase activity
SAR11_RS00995	COG0745	RESPONSE REGULATOR receiver
SAR11_RS01000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAR11_RS01000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAR11_RS01005	COG1131	(ABC) transporter
SAR11_RS01020	COG0019	diaminopimelate decarboxylase activity
SAR11_RS01030	COG0010	Belongs to the arginase family
SAR11_RS01040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SAR11_RS01045	COG0167	dihydroorotate dehydrogenase activity
SAR11_RS01050	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SAR11_RS01055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SAR11_RS01060	COG2223	nitrite transmembrane transporter activity
SAR11_RS01070	COG0287	Prephenate dehydrogenase
SAR11_RS01075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SAR11_RS01080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SAR11_RS01085	COG2813	Specifically methylates the guanine in position
SAR11_RS01085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SAR11_RS01090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAR11_RS01095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SAR11_RS01100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SAR11_RS01105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SAR11_RS01110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SAR11_RS01115	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SAR11_RS01120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SAR11_RS01130	COG0793	Belongs to the peptidase S41A family
SAR11_RS01135	COG1051	belongs to the nudix hydrolase family
SAR11_RS01140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SAR11_RS01145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SAR11_RS01150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SAR11_RS01155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SAR11_RS01160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAR11_RS01175	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAR11_RS01185	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SAR11_RS01190	COG0045	succinate-CoA ligase (ADP-forming) activity
SAR11_RS01195	COG0039	L-malate dehydrogenase activity
SAR11_RS01210	COG1053	succinate dehydrogenase
SAR11_RS01225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SAR11_RS01230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAR11_RS01235	COG2267	carboxylic ester hydrolase activity
SAR11_RS01240	COG0318	PFAM AMP-dependent synthetase and ligase
SAR11_RS01245	COG1960	acyl-CoA dehydrogenase activity
SAR11_RS01250	COG0473	3-isopropylmalate dehydrogenase activity
SAR11_RS01255	COG0066	3-isopropylmalate dehydratase activity
SAR11_RS01260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SAR11_RS01265	COG0335	large ribosomal subunit rRNA binding
SAR11_RS01270	COG0336	Belongs to the RNA methyltransferase TrmD family
SAR11_RS01275	COG0228	four-way junction DNA binding
SAR11_RS01280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SAR11_RS01285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SAR11_RS01290	COG0552	protein localization to endoplasmic reticulum
SAR11_RS01300	COG0697	spore germination
SAR11_RS01310	COG0154	amidase activity
SAR11_RS01330	COG3842	ATPase activity
SAR11_RS01340	COG0395	ABC-type sugar transport system, permease component
SAR11_RS01345	COG1175	transmembrane transport
SAR11_RS01355	COG1063	alcohol dehydrogenase
SAR11_RS01375	COG0247	lactate metabolic process
SAR11_RS01380	COG0277	FAD linked oxidase domain protein
SAR11_RS01385	COG0277	FAD linked oxidase domain protein
SAR11_RS01390	COG0436	Aminotransferase
SAR11_RS01395	COG1304	FMN binding
SAR11_RS01405	COG3088	subunit of a heme lyase
SAR11_RS01410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAR11_RS01415	COG1138	Cytochrome C-type biogenesis protein
SAR11_RS01420	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
SAR11_RS01430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SAR11_RS01440	COG2917	probably involved in intracellular septation
SAR11_RS01450	COG0670	Belongs to the BI1 family
SAR11_RS01455	COG0667	Aldo Keto reductase
SAR11_RS01465	COG0137	argininosuccinate synthase activity
SAR11_RS01495	COG0505	Belongs to the CarA family
SAR11_RS01500	COG2095	MarC family integral membrane protein
SAR11_RS01505	COG1238	metal cluster binding
SAR11_RS01515	COG3046	protein related to deoxyribodipyrimidine photolyase
SAR11_RS01520	COG0300	oxidoreductase activity
SAR11_RS01530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SAR11_RS01535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SAR11_RS01545	COG0668	transmembrane transport
SAR11_RS01555	COG0181	hydroxymethylbilane synthase activity
SAR11_RS01560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SAR11_RS01575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SAR11_RS01590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SAR11_RS01600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SAR11_RS01610	COG0138	bifunctional purine biosynthesis protein purh
SAR11_RS01615	COG2154	pterin-4-alpha-carbinolamine dehydratase
SAR11_RS01625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SAR11_RS01630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SAR11_RS01655	COG0140	phosphoribosyl-ATP diphosphatase activity
SAR11_RS01660	COG0107	imidazoleglycerol-phosphate synthase activity
SAR11_RS01665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SAR11_RS01670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SAR11_RS01675	COG0131	Imidazoleglycerol-phosphate dehydratase
SAR11_RS01680	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SAR11_RS01685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SAR11_RS01705	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
SAR11_RS01715	COG0237	dephospho-CoA kinase activity
SAR11_RS01720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SAR11_RS01725	COG0424	maF-like protein
SAR11_RS01730	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SAR11_RS01740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SAR11_RS01745	COG1981	membrane
SAR11_RS01750	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SAR11_RS01760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SAR11_RS01765	COG0445	tRNA wobble uridine modification
SAR11_RS01770	COG0357	Ribosomal RNA small subunit methyltransferase G
SAR11_RS01795	COG0495	leucyl-tRNA aminoacylation
SAR11_RS01810	COG0352	thiamine-phosphate diphosphorylase activity
SAR11_RS01830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SAR11_RS01835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SAR11_RS01840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SAR11_RS01845	COG0484	heat shock protein binding
SAR11_RS01850	COG0443	Heat shock 70 kDa protein
SAR11_RS01855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SAR11_RS01860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SAR11_RS01870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SAR11_RS01875	COG2823	Periplasmic or secreted lipoprotein
SAR11_RS01880	COG0280	phosphate acetyltransferase
SAR11_RS01880	COG0281	malic enzyme
SAR11_RS01885	COG0728	peptidoglycan biosynthetic process
SAR11_RS01890	COG0180	Tryptophanyl-tRNA synthetase
SAR11_RS01895	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SAR11_RS01920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SAR11_RS01925	COG1702	phosphate starvation-inducible protein PhoH
SAR11_RS01930	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SAR11_RS01935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SAR11_RS01940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SAR11_RS01950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SAR11_RS01955	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SAR11_RS01960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SAR11_RS01965	COG1185	polyribonucleotide nucleotidyltransferase activity
SAR11_RS01980	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SAR11_RS01990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SAR11_RS02020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SAR11_RS02025	COG0756	dUTP diphosphatase activity
SAR11_RS02030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SAR11_RS02035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SAR11_RS02040	COG2226	methyltransferase
SAR11_RS02045	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAR11_RS02050	COG0268	Binds directly to 16S ribosomal RNA
SAR11_RS02055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SAR11_RS02065	COG0204	Acyl-transferase
SAR11_RS02070	COG0019	diaminopimelate decarboxylase activity
SAR11_RS02075	COG0165	Argininosuccinate lyase
SAR11_RS02080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAR11_RS02100	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
SAR11_RS02110	COG1238	metal cluster binding
SAR11_RS02130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SAR11_RS02155	COG0183	Belongs to the thiolase family
SAR11_RS02165	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAR11_RS02175	COG1968	undecaprenyl-diphosphatase activity
SAR11_RS02205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SAR11_RS02210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SAR11_RS02215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SAR11_RS02220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SAR11_RS02225	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SAR11_RS02230	COG0072	phenylalanine-tRNA ligase activity
SAR11_RS02235	COG0481	GTPase activity
SAR11_RS02250	COG0187	DNA topoisomerase II activity
SAR11_RS02280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SAR11_RS02285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SAR11_RS02295	COG0242	peptide deformylase activity
SAR11_RS02300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SAR11_RS02305	COG0101	tRNA pseudouridine synthase activity
SAR11_RS02315	COG0123	including yeast histone deacetylase and acetoin utilization protein
SAR11_RS02325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAR11_RS02330	COG2171	N-acyltransferase activity
SAR11_RS02340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SAR11_RS02345	COG0706	membrane insertase activity
SAR11_RS02350	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SAR11_RS02360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SAR11_RS02380	COG0717	Belongs to the dCTP deaminase family
SAR11_RS02385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAR11_RS02395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SAR11_RS02400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SAR11_RS02420	COG0124	histidyl-tRNA synthetase
SAR11_RS02425	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SAR11_RS02430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SAR11_RS02450	COG3118	belongs to the thioredoxin family
SAR11_RS02460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SAR11_RS02465	COG0159	tryptophan synthase activity
SAR11_RS02470	COG0133	tryptophan synthase activity
SAR11_RS02475	COG0135	phosphoribosylanthranilate isomerase activity
SAR11_RS02480	COG0284	orotidine-5'-phosphate decarboxylase activity
SAR11_RS02485	COG0776	regulation of translation
SAR11_RS02490	COG0539	negative regulation of cytoplasmic translation
SAR11_RS02500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SAR11_RS02505	COG1137	ATPase activity
SAR11_RS02515	COG0517	IMP dehydrogenase activity
SAR11_RS02515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SAR11_RS02535	COG0842	Transport permease protein
SAR11_RS02540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SAR11_RS02545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SAR11_RS02550	COG3474	cytochrome
SAR11_RS02555	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
SAR11_RS02565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SAR11_RS02570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SAR11_RS02575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SAR11_RS02580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SAR11_RS02585	COG0825	malonyl-CoA metabolic process
SAR11_RS02590	COG0653	protein targeting
SAR11_RS02595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SAR11_RS02605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SAR11_RS02610	COG0527	aspartate kinase activity
SAR11_RS02615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SAR11_RS02620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SAR11_RS02625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SAR11_RS02625	COG2890	protein-(glutamine-N5) methyltransferase activity
SAR11_RS02635	COG0739	heme binding
SAR11_RS02680	COG0028	Belongs to the TPP enzyme family
SAR11_RS02685	COG2226	methyltransferase
SAR11_RS02690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SAR11_RS02700	COG1028	Short-chain dehydrogenase reductase Sdr
SAR11_RS02715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SAR11_RS02725	COG3958	Transketolase
SAR11_RS02730	COG3959	Transketolase, thiamine diphosphate binding domain
SAR11_RS02740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SAR11_RS02740	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SAR11_RS02750	COG1088	dTDP-glucose 4,6-dehydratase activity
SAR11_RS02770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SAR11_RS02805	COG0463	Glycosyl transferase, family 2
SAR11_RS02810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SAR11_RS02815	COG2192	nodulation
SAR11_RS02820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAR11_RS02825	COG0438	transferase activity, transferring glycosyl groups
SAR11_RS02840	COG0438	transferase activity, transferring glycosyl groups
SAR11_RS02855	COG1216	Glycosyl transferase, family 2
SAR11_RS02890	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SAR11_RS02895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SAR11_RS02910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SAR11_RS02940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SAR11_RS02950	COG0254	rRNA binding
SAR11_RS02955	COG0483	inositol monophosphate 1-phosphatase activity
SAR11_RS02960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SAR11_RS02965	COG0352	thiamine-phosphate diphosphorylase activity
SAR11_RS02975	COG0126	phosphoglycerate kinase activity
SAR11_RS03000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SAR11_RS03005	COG1692	metallophosphoesterase
SAR11_RS03010	COG0217	transcriptional regulatory protein
SAR11_RS03020	COG0811	peptide transport
SAR11_RS03035	COG0823	Involved in the tonB-independent uptake of proteins
SAR11_RS03040	COG2885	chlorophyll binding
SAR11_RS03050	COG0037	tRNA processing
SAR11_RS03060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SAR11_RS03065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAR11_RS03070	COG0352	thiamine-phosphate diphosphorylase activity
SAR11_RS03070	COG0351	phosphomethylpyrimidine kinase
SAR11_RS03075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SAR11_RS03085	COG0564	pseudouridine synthase activity
SAR11_RS03095	COG0009	L-threonylcarbamoyladenylate synthase
SAR11_RS03105	COG0142	geranyltranstransferase activity
SAR11_RS03110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SAR11_RS03115	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SAR11_RS03120	COG0259	pyridoxamine-phosphate oxidase activity
SAR11_RS03135	COG0752	glycyl-tRNA synthetase alpha subunit
SAR11_RS03145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAR11_RS03145	COG0574	Belongs to the PEP-utilizing enzyme family
SAR11_RS03150	COG0157	Belongs to the NadC ModD family
SAR11_RS03155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SAR11_RS03160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAR11_RS03185	COG0633	Ferredoxin
SAR11_RS03190	COG0492	ferredoxin-NADP+ reductase activity
SAR11_RS03195	COG0625	glutathione transferase activity
SAR11_RS03240	COG0572	uridine kinase
SAR11_RS03250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SAR11_RS03255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAR11_RS03260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SAR11_RS03265	COG0538	isocitrate dehydrogenase activity
SAR11_RS03270	COG0688	phosphatidylethanolamine metabolic process
SAR11_RS03275	COG1183	phosphatidylcholine synthase activity
SAR11_RS03285	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
SAR11_RS03300	COG0519	Catalyzes the synthesis of GMP from XMP
SAR11_RS03305	COG0346	lactoylglutathione lyase activity
SAR11_RS03310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SAR11_RS03345	COG4336	lyase activity
SAR11_RS03355	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SAR11_RS03365	COG1984	allophanate hydrolase subunit 2
SAR11_RS03375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAR11_RS03380	COG0509	glycine decarboxylation via glycine cleavage system
SAR11_RS03385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAR11_RS03385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SAR11_RS03400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SAR11_RS03410	COG0300	oxidoreductase activity
SAR11_RS03415	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SAR11_RS03420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAR11_RS03430	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SAR11_RS03435	COG3383	formate dehydrogenase (NAD+) activity
SAR11_RS03440	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SAR11_RS03445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SAR11_RS03460	COG0746	molybdenum cofactor guanylyltransferase activity
SAR11_RS03465	COG0303	'Molybdopterin
SAR11_RS03500	COG1666	GTP binding
SAR11_RS03510	COG2081	HI0933 family
SAR11_RS03515	COG2814	Major facilitator Superfamily
SAR11_RS03525	COG0189	ligase activity
SAR11_RS03530	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SAR11_RS03535	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SAR11_RS03550	COG0305	Participates in initiation and elongation during chromosome replication
SAR11_RS03555	COG0359	binds to the 23S rRNA
SAR11_RS03560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAR11_RS03565	COG0360	Binds together with S18 to 16S ribosomal RNA
SAR11_RS03570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SAR11_RS03585	COG0194	GDP metabolic process
SAR11_RS03590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAR11_RS03595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SAR11_RS03600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SAR11_RS03605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SAR11_RS03620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SAR11_RS03625	COG0105	UTP biosynthetic process
SAR11_RS03630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SAR11_RS03635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SAR11_RS03650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SAR11_RS03655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAR11_RS03670	COG0439	Biotin carboxylase
SAR11_RS03690	COG2022	thiamine diphosphate biosynthetic process
SAR11_RS03695	COG1530	ribonuclease E activity
SAR11_RS03705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SAR11_RS03715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SAR11_RS03720	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SAR11_RS03725	COG2945	thiolester hydrolase activity
SAR11_RS03735	COG0719	Fe-S assembly protein
SAR11_RS03740	COG0396	ATPase activity
SAR11_RS03745	COG0719	Fe-S assembly protein
SAR11_RS03750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAR11_RS03755	COG0822	iron-sulfur transferase activity
SAR11_RS03760	COG2151	metal-sulfur cluster biosynthetic enzyme
SAR11_RS03765	COG0316	Belongs to the HesB IscA family
SAR11_RS03770	COG0174	glutamine synthetase
SAR11_RS03775	COG0442	prolyl-tRNA aminoacylation
SAR11_RS03785	COG0646	methionine synthase
SAR11_RS03785	COG1410	methionine synthase
SAR11_RS03800	COG0521	Mo-molybdopterin cofactor biosynthetic process
SAR11_RS03810	COG1012	belongs to the aldehyde dehydrogenase family
SAR11_RS03825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SAR11_RS03830	COG0314	molybdopterin synthase activity
SAR11_RS03840	COG0315	cyclic pyranopterin monophosphate synthase activity
SAR11_RS03860	COG1012	belongs to the aldehyde dehydrogenase family
SAR11_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
SAR11_RS03870	COG1940	carbohydrate kinase activity
SAR11_RS03880	COG1175	transmembrane transport
SAR11_RS03885	COG0395	ABC-type sugar transport system, permease component
SAR11_RS03890	COG3842	ATPase activity
SAR11_RS03895	COG1028	Short-chain dehydrogenase reductase Sdr
SAR11_RS03900	COG0129	dihydroxy-acid dehydratase activity
SAR11_RS03905	COG1028	Short-chain dehydrogenase reductase Sdr
SAR11_RS03910	COG0179	Fumarylacetoacetate (FAA) hydrolase
SAR11_RS03920	COG2084	Dehydrogenase
SAR11_RS03925	COG0179	Fumarylacetoacetate (FAA) hydrolase
SAR11_RS03935	COG0785	Cytochrome C biogenesis protein
SAR11_RS03940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SAR11_RS03980	COG1045	serine acetyltransferase
SAR11_RS04010	COG1012	belongs to the aldehyde dehydrogenase family
SAR11_RS04020	COG4175	Glycine betaine
SAR11_RS04020	COG3448	diguanylate cyclase activity
SAR11_RS04025	COG4176	ABC-type proline glycine betaine transport system permease component
SAR11_RS04035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SAR11_RS04045	COG0596	Alpha beta hydrolase
SAR11_RS04055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SAR11_RS04060	COG1116	anion transmembrane transporter activity
SAR11_RS04070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SAR11_RS04075	COG0686	Belongs to the AlaDH PNT family
SAR11_RS04090	COG1131	(ABC) transporter
SAR11_RS04095	COG0842	Transport permease protein
SAR11_RS04105	COG0750	zinc metalloprotease
SAR11_RS04110	COG0776	regulation of translation
SAR11_RS04115	COG0004	ammonium transporteR
SAR11_RS04120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SAR11_RS04130	COG1054	Belongs to the UPF0176 family
SAR11_RS04145	COG2137	regulation of response to DNA damage stimulus
SAR11_RS04155	COG1218	3'(2'),5'-bisphosphate nucleotidase
SAR11_RS04160	COG0482	sulfurtransferase activity
SAR11_RS04165	COG0626	cystathionine gamma-synthase activity
SAR11_RS04175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SAR11_RS04180	COG0512	Glutamine amidotransferase of anthranilate synthase
SAR11_RS04220	COG0730	response to heat
SAR11_RS04235	COG2721	sulfolactate sulfo-lyase activity
SAR11_RS04240	COG0028	Belongs to the TPP enzyme family
SAR11_RS04245	COG2072	flavoprotein involved in K transport
SAR11_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
SAR11_RS04265	COG1136	(ABC) transporter
SAR11_RS04295	COG1028	Short-chain dehydrogenase reductase Sdr
SAR11_RS04300	COG0861	Integral membrane protein TerC family
SAR11_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
SAR11_RS04325	COG1012	belongs to the aldehyde dehydrogenase family
SAR11_RS04335	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
SAR11_RS04355	COG1953	Uracil, thiamine, allantoin
SAR11_RS04360	COG1028	Short-chain dehydrogenase reductase Sdr
SAR11_RS04375	COG0824	Thioesterase
SAR11_RS04380	COG1573	uracil-dna glycosylase
SAR11_RS04405	COG0544	peptidyl-prolyl cis-trans isomerase activity
SAR11_RS04410	COG0740	serine-type endopeptidase activity
SAR11_RS04415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SAR11_RS04435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAR11_RS04440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAR11_RS04445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAR11_RS04450	COG0649	NAD binding
SAR11_RS04455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SAR11_RS04465	COG1034	ATP synthesis coupled electron transport
SAR11_RS04470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SAR11_RS04475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SAR11_RS04485	COG0713	ATP synthesis coupled electron transport
SAR11_RS04500	COG1007	ATP synthesis coupled electron transport
SAR11_RS04510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SAR11_RS04525	COG0442	prolyl-tRNA aminoacylation
SAR11_RS04535	COG1136	(ABC) transporter
SAR11_RS04545	COG0052	Belongs to the universal ribosomal protein uS2 family
SAR11_RS04550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SAR11_RS04560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAR11_RS04565	COG4589	Belongs to the CDS family
SAR11_RS04570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SAR11_RS04575	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SAR11_RS04590	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SAR11_RS04595	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SAR11_RS04610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SAR11_RS04615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SAR11_RS04620	COG0134	indole-3-glycerol-phosphate synthase activity
SAR11_RS04625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SAR11_RS04635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SAR11_RS04645	COG0149	triose-phosphate isomerase activity
SAR11_RS04690	COG0504	CTP synthase activity
SAR11_RS04695	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SAR11_RS04700	COG0148	phosphopyruvate hydratase activity
SAR11_RS04710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SAR11_RS04720	COG1546	Belongs to the CinA family
SAR11_RS04720	COG1058	Belongs to the CinA family
SAR11_RS04725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SAR11_RS04730	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SAR11_RS04730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SAR11_RS04735	COG5000	phosphorelay sensor kinase activity
SAR11_RS04740	COG2204	response regulator
SAR11_RS04745	COG0569	domain protein
SAR11_RS04750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SAR11_RS04760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAR11_RS04765	COG4597	amino acid ABC transporter
SAR11_RS04770	COG0765	amino acid transport
SAR11_RS04775	COG1126	abc transporter atp-binding protein
SAR11_RS04780	COG1396	sequence-specific DNA binding
SAR11_RS04800	COG0525	valine-tRNA ligase activity
SAR11_RS04805	COG0129	dihydroxy-acid dehydratase activity
SAR11_RS04810	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SAR11_RS04810	COG0662	Cupin 2, conserved barrel domain protein
SAR11_RS04840	COG0316	Belongs to the HesB IscA family
SAR11_RS04845	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SAR11_RS04850	COG0018	arginyl-trna synthetase
SAR11_RS04860	COG1472	Belongs to the glycosyl hydrolase 3 family
SAR11_RS04865	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SAR11_RS04875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAR11_RS04880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SAR11_RS04885	COG0805	protein transport
SAR11_RS04890	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SAR11_RS04895	COG1862	Preprotein translocase
SAR11_RS04900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SAR11_RS04915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAR11_RS04920	COG0629	single-stranded DNA binding
SAR11_RS04925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAR11_RS04930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SAR11_RS04940	COG0343	queuine tRNA-ribosyltransferase activity
SAR11_RS04960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SAR11_RS04975	COG2962	Rard protein
SAR11_RS04980	COG2951	lytic endotransglycosylase activity
SAR11_RS04990	COG1686	Belongs to the peptidase S11 family
SAR11_RS04995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SAR11_RS05000	COG0470	DNA polymerase III
SAR11_RS05005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAR11_RS05010	COG0084	hydrolase, TatD family'
SAR11_RS05015	COG0321	lipoyl(octanoyl) transferase activity
SAR11_RS05015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SAR11_RS05020	COG0386	Belongs to the glutathione peroxidase family
SAR11_RS05025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SAR11_RS05045	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
SAR11_RS05050	COG1494	fructose-1,6-bisphosphatase
SAR11_RS05055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SAR11_RS05065	COG2827	Endonuclease containing a URI domain
SAR11_RS05115	COG2169	Transcriptional regulator
SAR11_RS05115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SAR11_RS05130	COG0460	homoserine dehydrogenase
SAR11_RS05140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SAR11_RS05145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SAR11_RS05150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SAR11_RS05160	COG1612	heme a metabolic process
SAR11_RS05180	COG0776	regulation of translation
SAR11_RS05185	COG0416	fatty acid biosynthetic process
SAR11_RS05190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SAR11_RS05205	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SAR11_RS05210	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SAR11_RS05215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SAR11_RS05220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SAR11_RS05225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAR11_RS05225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SAR11_RS05230	COG0307	riboflavin synthase, alpha
SAR11_RS05235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAR11_RS05235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SAR11_RS05240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SAR11_RS05245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAR11_RS05260	COG0113	porphobilinogen synthase activity
SAR11_RS05265	COG1381	Involved in DNA repair and RecF pathway recombination
SAR11_RS05270	COG0571	ribonuclease III activity
SAR11_RS05280	COG0736	holo-[acyl-carrier-protein] synthase activity
SAR11_RS05285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SAR11_RS05295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SAR11_RS05300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SAR11_RS05305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SAR11_RS05310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAR11_RS05315	COG0741	lytic transglycosylase activity
SAR11_RS05335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAR11_RS05335	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAR11_RS05345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAR11_RS05350	COG0765	amino acid transport
SAR11_RS05370	COG1054	Belongs to the UPF0176 family
SAR11_RS05375	COG4122	O-methyltransferase activity
SAR11_RS05380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAR11_RS05385	COG0154	amidase activity
SAR11_RS05390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAR11_RS05395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SAR11_RS05400	COG0540	Belongs to the ATCase OTCase family
SAR11_RS05405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAR11_RS05410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SAR11_RS05415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAR11_RS05430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SAR11_RS05440	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SAR11_RS05450	COG0321	lipoyl(octanoyl) transferase activity
SAR11_RS05455	COG0564	pseudouridine synthase activity
SAR11_RS05460	COG0203	ribosomal protein L17
SAR11_RS05465	COG0202	RNA polymerase activity
SAR11_RS05470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SAR11_RS05475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SAR11_RS05480	COG0563	adenylate kinase activity
SAR11_RS05485	COG0201	protein transport
SAR11_RS05490	COG0200	Binds to the 23S rRNA
SAR11_RS05495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SAR11_RS05500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SAR11_RS05505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SAR11_RS05510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SAR11_RS05515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAR11_RS05520	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SAR11_RS05525	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SAR11_RS05530	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SAR11_RS05535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SAR11_RS05545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SAR11_RS05550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SAR11_RS05555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SAR11_RS05560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SAR11_RS05565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SAR11_RS05570	COG0089	rRNA binding
SAR11_RS05575	COG0088	Forms part of the polypeptide exit tunnel
SAR11_RS05580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SAR11_RS05585	COG0051	transcription antitermination factor activity, RNA binding
SAR11_RS05590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SAR11_RS05595	COG0049	tRNA binding
SAR11_RS05600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SAR11_RS05605	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SAR11_RS05610	COG0085	RNA polymerase activity
SAR11_RS05615	COG0222	ribosome binding
SAR11_RS05620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SAR11_RS05625	COG0081	regulation of translation
SAR11_RS05630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SAR11_RS05640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SAR11_RS05650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAR11_RS05665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAR11_RS05675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SAR11_RS05695	COG1489	DNA binding
SAR11_RS05700	COG0024	Methionine aminopeptidase
SAR11_RS05705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAR11_RS05710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SAR11_RS05715	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAR11_RS05720	COG0047	phosphoribosylformylglycinamidine synthase activity
SAR11_RS05725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SAR11_RS05735	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SAR11_RS05740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SAR11_RS05745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SAR11_RS05750	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SAR11_RS05755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SAR11_RS05760	COG0215	cysteine-tRNA ligase activity
SAR11_RS05765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SAR11_RS05770	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SAR11_RS05775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SAR11_RS05780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SAR11_RS05785	COG0546	phosphoglycolate phosphatase activity
SAR11_RS05790	COG2079	MmgE PrpD family protein
SAR11_RS05795	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SAR11_RS05810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAR11_RS05815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SAR11_RS05820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAR11_RS05880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAR11_RS05900	COG0745	RESPONSE REGULATOR receiver
SAR11_RS05910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SAR11_RS05915	COG0581	inorganic phosphate transmembrane transporter activity
SAR11_RS05920	COG0573	inorganic phosphate transmembrane transporter activity
SAR11_RS05930	COG5002	protein histidine kinase activity
SAR11_RS05965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SAR11_RS05980	COG0659	secondary active sulfate transmembrane transporter activity
SAR11_RS05990	COG0730	response to heat
SAR11_RS05995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SAR11_RS06000	COG1758	RNA polymerase activity
SAR11_RS06010	COG2084	Dehydrogenase
SAR11_RS06030	COG0438	transferase activity, transferring glycosyl groups
SAR11_RS06080	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SAR11_RS06085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SAR11_RS06090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAR11_RS06170	COG0534	Mate efflux family protein
SAR11_RS06175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAR11_RS06205	COG3842	ATPase activity
SAR11_RS06215	COG1840	ABC-type Fe3 transport system, periplasmic component
SAR11_RS06220	COG2224	Isocitrate lyase
SAR11_RS06230	COG0583	DNA-binding transcription factor activity
SAR11_RS06235	COG0604	alcohol dehydrogenase
SAR11_RS06240	COG0302	gtp cyclohydrolase
SAR11_RS06245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SAR11_RS06275	COG2086	electron transfer activity
SAR11_RS06290	COG2249	NAD(P)H dehydrogenase (quinone) activity
SAR11_RS06300	COG2391	methyltransferase activity
SAR11_RS06310	COG1832	CoA-binding protein
SAR11_RS06315	COG1024	Enoyl-CoA hydratase
SAR11_RS06325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SAR11_RS06330	COG4638	Rieske (2fe-2S)
SAR11_RS06340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAR11_RS06365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SAR11_RS06375	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SAR11_RS06375	COG0165	Argininosuccinate lyase
SAR11_RS06380	COG1278	Cold shock
SAR11_RS06420	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAR11_RS06420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAR11_RS06430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAR11_RS06435	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SAR11_RS06450	COG1012	belongs to the aldehyde dehydrogenase family
SAR11_RS06455	COG1028	Short-chain dehydrogenase reductase Sdr
SAR11_RS06480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SAR11_RS06485	COG0492	ferredoxin-NADP+ reductase activity
SAR11_RS06490	COG4176	ABC-type proline glycine betaine transport system permease component
SAR11_RS06495	COG0517	IMP dehydrogenase activity
SAR11_RS06495	COG4175	Glycine betaine
SAR11_RS06520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SAR11_RS06550	COG0069	glutamate synthase activity
SAR11_RS06560	COG0004	ammonium transporteR
SAR11_RS06575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SAR11_RS06580	COG2218	PFAM glutamate synthase alpha subunit domain protein
SAR11_RS06585	COG0069	glutamate synthase activity
SAR11_RS06590	COG0174	glutamine synthetase
SAR11_RS06600	COG0415	Belongs to the DNA photolyase family
SAR11_RS06605	COG0432	Pfam Uncharacterised protein family UPF0047
SAR11_RS06610	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SAR11_RS06630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SAR11_RS06635	COG1280	lysine exporter protein (LysE YggA)
SAR11_RS06640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAR11_RS06645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAR11_RS06675	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAR11_RS06675	COG1024	Enoyl-CoA hydratase
SAR11_RS06680	COG1177	transmembrane transport
SAR11_RS06695	COG3842	ATPase activity
SAR11_RS06700	COG0006	proline dipeptidase activity
SAR11_RS06725	COG1012	belongs to the aldehyde dehydrogenase family
SAR11_RS06730	COG0697	spore germination
SAR11_RS06735	COG0683	leucine binding
SAR11_RS06745	COG2814	Major facilitator Superfamily
SAR11_RS06755	COG4603	Belongs to the binding-protein-dependent transport system permease family
SAR11_RS06800	COG1172	Belongs to the binding-protein-dependent transport system permease family
SAR11_RS06825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SAR11_RS06830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAR11_RS06835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SAR11_RS06845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAR11_RS06845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SAR11_RS06850	COG0772	Belongs to the SEDS family
SAR11_RS06875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)