locus-tag	class	description
A1s21155_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A1s21155_RS00010	COG0592	DNA-directed DNA polymerase activity
A1s21155_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A1s21155_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A1s21155_RS00025	COG0443	Heat shock 70 kDa protein
A1s21155_RS00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A1s21155_RS00035	COG0484	heat shock protein binding
A1s21155_RS00040	COG0789	Transcriptional regulator
A1s21155_RS00055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A1s21155_RS00060	COG0586	Pfam SNARE associated Golgi protein
A1s21155_RS00070	COG1653	transport
A1s21155_RS00075	COG1175	transmembrane transport
A1s21155_RS00080	COG0395	ABC-type sugar transport system, permease component
A1s21155_RS00085	COG2723	6-phospho-beta-galactosidase activity
A1s21155_RS00090	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A1s21155_RS00095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A1s21155_RS00095	COG1754	DNA topoisomerase type I activity
A1s21155_RS00115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A1s21155_RS00120	COG0470	DNA polymerase III
A1s21155_RS00130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1s21155_RS00135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A1s21155_RS00145	COG2089	acid synthase
A1s21155_RS00155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A1s21155_RS00165	COG0107	imidazoleglycerol-phosphate synthase activity
A1s21155_RS00180	COG1083	cytidylyl-transferase
A1s21155_RS00185	COG1028	Short-chain dehydrogenase reductase Sdr
A1s21155_RS00200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A1s21155_RS00220	COG1086	Polysaccharide biosynthesis protein
A1s21155_RS00240	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A1s21155_RS00245	COG1028	Short-chain dehydrogenase reductase Sdr
A1s21155_RS00250	COG1028	Short-chain dehydrogenase reductase Sdr
A1s21155_RS00260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A1s21155_RS00260	COG0517	IMP dehydrogenase activity
A1s21155_RS00265	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A1s21155_RS00270	COG1132	(ABC) transporter
A1s21155_RS00275	COG0546	phosphoglycolate phosphatase activity
A1s21155_RS00300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A1s21155_RS00300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1s21155_RS00305	COG4702	Belongs to the UPF0303 family
A1s21155_RS00320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A1s21155_RS00325	COG0456	acetyltransferase
A1s21155_RS00330	COG0745	RESPONSE REGULATOR receiver
A1s21155_RS00345	COG0735	belongs to the Fur family
A1s21155_RS00360	COG4044	May play a role in the intracellular transport of hydrophobic ligands
A1s21155_RS00380	COG0438	transferase activity, transferring glycosyl groups
A1s21155_RS00390	COG0588	phosphoglycerate mutase activity
A1s21155_RS00400	COG1329	Transcriptional regulator
A1s21155_RS00405	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A1s21155_RS00405	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A1s21155_RS00410	COG0215	cysteine-tRNA ligase activity
A1s21155_RS00415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1s21155_RS00445	COG1252	NADH dehydrogenase
A1s21155_RS00450	COG0702	epimerase
A1s21155_RS00460	COG0459	protein refolding
A1s21155_RS00480	COG2814	Major facilitator Superfamily
A1s21155_RS00490	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A1s21155_RS00495	COG0259	pyridoxamine-phosphate oxidase activity
A1s21155_RS00505	COG0415	Belongs to the DNA photolyase family
A1s21155_RS00530	COG0513	Belongs to the DEAD box helicase family
A1s21155_RS00535	COG0300	oxidoreductase activity
A1s21155_RS00555	COG0788	formyltetrahydrofolate deformylase activity
A1s21155_RS00560	COG2409	Drug exporters of the RND superfamily
A1s21155_RS00580	COG1960	acyl-CoA dehydrogenase activity
A1s21155_RS00585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A1s21155_RS00615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1s21155_RS00620	COG0084	hydrolase, TatD family'
A1s21155_RS00625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A1s21155_RS00630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A1s21155_RS00635	COG1846	Transcriptional regulator
A1s21155_RS00645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A1s21155_RS00650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A1s21155_RS00655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A1s21155_RS00660	COG0193	aminoacyl-tRNA hydrolase activity
A1s21155_RS00665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A1s21155_RS00685	COG0148	phosphopyruvate hydratase activity
A1s21155_RS00720	COG2814	Major facilitator Superfamily
A1s21155_RS00740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A1s21155_RS00760	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A1s21155_RS00770	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A1s21155_RS00770	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A1s21155_RS00775	COG1722	exodeoxyribonuclease VII activity
A1s21155_RS00780	COG1570	exodeoxyribonuclease VII activity
A1s21155_RS00785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A1s21155_RS00790	COG2267	carboxylic ester hydrolase activity
A1s21155_RS00805	COG0012	GTP binding
A1s21155_RS00810	COG1217	gtp-binding protein TYPA
A1s21155_RS00815	COG0210	DNA helicase
A1s21155_RS00820	COG0210	DNA helicase
A1s21155_RS00825	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A1s21155_RS00880	COG3480	Lon protease (S16) C-terminal proteolytic domain
A1s21155_RS00885	COG1615	UPF0182 protein
A1s21155_RS00900	COG0483	inositol monophosphate 1-phosphatase activity
A1s21155_RS00905	COG1162	GTPase activity
A1s21155_RS00910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A1s21155_RS00915	COG2135	peptidase activity
A1s21155_RS00920	COG1595	DNA-templated transcription, initiation
A1s21155_RS00945	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A1s21155_RS00950	COG0567	Dehydrogenase, E1 component
A1s21155_RS00950	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1s21155_RS01005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A1s21155_RS01010	COG2884	Cell division ATP-binding protein ftsE
A1s21155_RS01015	COG2177	Part of the ABC transporter FtsEX involved in
A1s21155_RS01020	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A1s21155_RS01035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A1s21155_RS01055	COG1741	Belongs to the pirin family
A1s21155_RS01060	COG1054	Belongs to the UPF0176 family
A1s21155_RS01080	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A1s21155_RS01105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A1s21155_RS01110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A1s21155_RS01115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A1s21155_RS01175	COG4214	carbohydrate transport
A1s21155_RS01185	COG4213	ABC transporter substrate-binding protein
A1s21155_RS01190	COG0018	arginyl-trna synthetase
A1s21155_RS01200	COG0460	homoserine dehydrogenase
A1s21155_RS01205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A1s21155_RS01210	COG0083	homoserine kinase activity
A1s21155_RS01220	COG0254	rRNA binding
A1s21155_RS01225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A1s21155_RS01230	COG2890	protein-(glutamine-N5) methyltransferase activity
A1s21155_RS01240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A1s21155_RS01260	COG0356	it plays a direct role in the translocation of protons across the membrane
A1s21155_RS01265	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A1s21155_RS01270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A1s21155_RS01275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A1s21155_RS01280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A1s21155_RS01285	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A1s21155_RS01290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A1s21155_RS01295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A1s21155_RS01310	COG0673	inositol 2-dehydrogenase activity
A1s21155_RS01315	COG0395	ABC-type sugar transport system, permease component
A1s21155_RS01335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A1s21155_RS01345	COG0667	Aldo Keto reductase
A1s21155_RS01405	COG1131	(ABC) transporter
A1s21155_RS01415	COG1012	belongs to the aldehyde dehydrogenase family
A1s21155_RS01445	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A1s21155_RS01485	COG0517	IMP dehydrogenase activity
A1s21155_RS01500	COG1175	transmembrane transport
A1s21155_RS01505	COG0395	ABC-type sugar transport system, permease component
A1s21155_RS01510	COG0246	Mannitol dehydrogenase
A1s21155_RS01515	COG1063	alcohol dehydrogenase
A1s21155_RS01590	COG0697	spore germination
A1s21155_RS01595	COG0673	inositol 2-dehydrogenase activity
A1s21155_RS01600	COG0673	inositol 2-dehydrogenase activity
A1s21155_RS01610	COG1082	Xylose isomerase domain protein TIM barrel
A1s21155_RS01615	COG3962	Belongs to the TPP enzyme family
A1s21155_RS01660	COG1982	Orn Lys Arg decarboxylase major
A1s21155_RS01680	COG0363	glucosamine-6-phosphate deaminase activity
A1s21155_RS01685	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A1s21155_RS01710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A1s21155_RS01725	COG0444	Belongs to the ABC transporter superfamily
A1s21155_RS01730	COG4608	Belongs to the ABC transporter superfamily
A1s21155_RS01740	COG3590	peptidase
A1s21155_RS01760	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A1s21155_RS01765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A1s21155_RS01765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A1s21155_RS01770	COG0174	glutamine synthetase
A1s21155_RS01780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A1s21155_RS01785	COG1381	Involved in DNA repair and RecF pathway recombination
A1s21155_RS01790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A1s21155_RS01820	COG0423	glycine-tRNA ligase activity
A1s21155_RS01835	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A1s21155_RS01855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1s21155_RS01865	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A1s21155_RS01875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A1s21155_RS01880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A1s21155_RS01895	COG2197	response regulator
A1s21155_RS01905	COG5002	protein histidine kinase activity
A1s21155_RS01925	COG0494	nUDIX hydrolase
A1s21155_RS01925	COG0406	alpha-ribazole phosphatase activity
A1s21155_RS01930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A1s21155_RS01945	COG0686	Belongs to the AlaDH PNT family
A1s21155_RS01970	COG1278	Cold shock
A1s21155_RS01995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1s21155_RS02000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A1s21155_RS02015	COG0438	transferase activity, transferring glycosyl groups
A1s21155_RS02020	COG0438	transferase activity, transferring glycosyl groups
A1s21155_RS02020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A1s21155_RS02030	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A1s21155_RS02040	COG0482	sulfurtransferase activity
A1s21155_RS02045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A1s21155_RS02050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A1s21155_RS02055	COG0799	negative regulation of ribosome biogenesis
A1s21155_RS02060	COG0588	phosphoglycerate mutase activity
A1s21155_RS02070	COG0495	leucyl-tRNA aminoacylation
A1s21155_RS02080	COG2333	competence protein COMEC
A1s21155_RS02080	COG0658	competence protein
A1s21155_RS02090	COG0268	Binds directly to 16S ribosomal RNA
A1s21155_RS02095	COG0481	GTPase activity
A1s21155_RS02105	COG1420	regulation of RNA biosynthetic process
A1s21155_RS02110	COG0484	heat shock protein binding
A1s21155_RS02115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A1s21155_RS02140	COG0179	Fumarylacetoacetate (FAA) hydrolase
A1s21155_RS02145	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A1s21155_RS02145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A1s21155_RS02160	COG0277	FAD linked oxidase domain protein
A1s21155_RS02165	COG1929	Belongs to the glycerate kinase type-1 family
A1s21155_RS02190	COG0010	Belongs to the arginase family
A1s21155_RS02255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1s21155_RS02340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A1s21155_RS02430	COG1388	LysM domain
A1s21155_RS02435	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A1s21155_RS02440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A1s21155_RS02460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A1s21155_RS02460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A1s21155_RS02465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A1s21155_RS02500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A1s21155_RS02505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A1s21155_RS02535	COG0488	(ABC) transporter
A1s21155_RS02545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A1s21155_RS02565	COG0335	large ribosomal subunit rRNA binding
A1s21155_RS02570	COG0681	Belongs to the peptidase S26 family
A1s21155_RS02575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A1s21155_RS02585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A1s21155_RS02590	COG1968	undecaprenyl-diphosphatase activity
A1s21155_RS02595	COG0697	spore germination
A1s21155_RS02600	COG0657	acetylesterase activity
A1s21155_RS02605	COG3046	protein related to deoxyribodipyrimidine photolyase
A1s21155_RS02610	COG1070	Carbohydrate kinase
A1s21155_RS02615	COG0205	6-phosphofructokinase activity
A1s21155_RS02620	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A1s21155_RS02625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A1s21155_RS02640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A1s21155_RS02645	COG2815	serine threonine protein kinase
A1s21155_RS02645	COG0515	serine threonine protein kinase
A1s21155_RS02650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A1s21155_RS02650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A1s21155_RS02670	COG0142	geranyltranstransferase activity
A1s21155_RS02680	COG1183	phosphatidylcholine synthase activity
A1s21155_RS02710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A1s21155_RS02725	COG0346	lactoylglutathione lyase activity
A1s21155_RS02740	COG2271	Major facilitator Superfamily
A1s21155_RS02745	COG0730	response to heat
A1s21155_RS02760	COG0587	DNA-directed DNA polymerase activity
A1s21155_RS02765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A1s21155_RS02775	COG2001	Belongs to the MraZ family
A1s21155_RS02780	COG0275	rRNA processing
A1s21155_RS02790	COG0768	penicillin binding
A1s21155_RS02795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A1s21155_RS02800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A1s21155_RS02805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A1s21155_RS02810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A1s21155_RS02820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A1s21155_RS02825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A1s21155_RS02835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A1s21155_RS02840	COG1496	oxidoreductase activity
A1s21155_RS02845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A1s21155_RS02850	COG1799	cell septum assembly
A1s21155_RS02860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A1s21155_RS02870	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A1s21155_RS02885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A1s21155_RS02890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A1s21155_RS02895	COG0131	Imidazoleglycerol-phosphate dehydratase
A1s21155_RS02905	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A1s21155_RS02910	COG0107	imidazoleglycerol-phosphate synthase activity
A1s21155_RS02915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A1s21155_RS02920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A1s21155_RS02925	COG0134	indole-3-glycerol-phosphate synthase activity
A1s21155_RS02930	COG0133	tryptophan synthase activity
A1s21155_RS02935	COG0159	tryptophan synthase activity
A1s21155_RS02950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A1s21155_RS02960	COG0067	glutamate synthase
A1s21155_RS02960	COG0069	glutamate synthase activity
A1s21155_RS02960	COG0070	glutamate synthase
A1s21155_RS03000	COG0411	ABC transporter
A1s21155_RS03010	COG2050	protein possibly involved in aromatic compounds catabolism
A1s21155_RS03025	COG0539	negative regulation of cytoplasmic translation
A1s21155_RS03030	COG0237	dephospho-CoA kinase activity
A1s21155_RS03035	COG0556	nucleotide-excision repair
A1s21155_RS03040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A1s21155_RS03045	COG0322	excinuclease ABC activity
A1s21155_RS03050	COG1660	Displays ATPase and GTPase activities
A1s21155_RS03060	COG1481	regulation of sporulation
A1s21155_RS03065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A1s21155_RS03070	COG0126	phosphoglycerate kinase activity
A1s21155_RS03075	COG0149	triose-phosphate isomerase activity
A1s21155_RS03080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A1s21155_RS03090	COG0166	Belongs to the GPI family
A1s21155_RS03100	COG1612	heme a metabolic process
A1s21155_RS03115	COG0719	Fe-S assembly protein
A1s21155_RS03120	COG2146	nitrite reductase [NAD(P)H] activity
A1s21155_RS03125	COG0396	ATPase activity
A1s21155_RS03130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A1s21155_RS03135	COG0822	iron-sulfur transferase activity
A1s21155_RS03140	COG2151	metal-sulfur cluster biosynthetic enzyme
A1s21155_RS03145	COG1132	(ABC) transporter
A1s21155_RS03165	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A1s21155_RS03170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A1s21155_RS03175	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A1s21155_RS03180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A1s21155_RS03185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1s21155_RS03190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A1s21155_RS03195	COG0072	phenylalanine-tRNA ligase activity
A1s21155_RS03195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1s21155_RS03200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A1s21155_RS03205	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A1s21155_RS03210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A1s21155_RS03215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A1s21155_RS03220	COG1438	arginine binding
A1s21155_RS03225	COG0165	Argininosuccinate lyase
A1s21155_RS03230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A1s21155_RS03275	COG0497	DNA recombination
A1s21155_RS03280	COG0504	CTP synthase activity
A1s21155_RS03300	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A1s21155_RS03305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A1s21155_RS03325	COG1160	GTP binding
A1s21155_RS03330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A1s21155_RS03335	COG0509	glycine decarboxylation via glycine cleavage system
A1s21155_RS03340	COG1716	ATPase activity
A1s21155_RS03360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A1s21155_RS03360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A1s21155_RS03365	COG0463	Glycosyl transferase, family 2
A1s21155_RS03370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A1s21155_RS03385	COG0805	protein transport
A1s21155_RS03395	COG2378	regulation of single-species biofilm formation
A1s21155_RS03400	COG2378	regulation of single-species biofilm formation
A1s21155_RS03415	COG0646	methionine synthase
A1s21155_RS03415	COG1410	methionine synthase
A1s21155_RS03425	COG0215	cysteine-tRNA ligase activity
A1s21155_RS03445	COG0667	Aldo Keto reductase
A1s21155_RS03450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A1s21155_RS03460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A1s21155_RS03470	COG1435	thymidine kinase activity
A1s21155_RS03475	COG1064	alcohol dehydrogenase
A1s21155_RS03485	COG2364	Membrane
A1s21155_RS03490	COG2252	PERMEase
A1s21155_RS03495	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A1s21155_RS03500	COG1119	ATPase activity
A1s21155_RS03505	COG0560	Phosphoserine phosphatase
A1s21155_RS03505	COG3830	Belongs to the UPF0237 family
A1s21155_RS03510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A1s21155_RS03520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A1s21155_RS03530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A1s21155_RS03535	COG0242	peptide deformylase activity
A1s21155_RS03545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A1s21155_RS03555	COG1758	RNA polymerase activity
A1s21155_RS03560	COG0194	GDP metabolic process
A1s21155_RS03565	COG0284	orotidine-5'-phosphate decarboxylase activity
A1s21155_RS03570	COG0167	dihydroorotate dehydrogenase activity
A1s21155_RS03575	COG0543	2 iron, 2 sulfur cluster binding
A1s21155_RS03580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A1s21155_RS03585	COG0505	Belongs to the CarA family
A1s21155_RS03590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A1s21155_RS03595	COG0540	Belongs to the ATCase OTCase family
A1s21155_RS03600	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A1s21155_RS03610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A1s21155_RS03615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A1s21155_RS03620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A1s21155_RS03625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A1s21155_RS03630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A1s21155_RS03635	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A1s21155_RS03655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A1s21155_RS03660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A1s21155_RS03670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A1s21155_RS03675	COG0124	histidyl-tRNA synthetase
A1s21155_RS03680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1s21155_RS03685	COG1196	nuclear chromosome segregation
A1s21155_RS03690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A1s21155_RS03695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A1s21155_RS03700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A1s21155_RS03705	COG2255	four-way junction helicase activity
A1s21155_RS03710	COG0632	four-way junction helicase activity
A1s21155_RS03715	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A1s21155_RS03720	COG0217	transcriptional regulatory protein
A1s21155_RS03725	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A1s21155_RS03730	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A1s21155_RS03745	COG0438	transferase activity, transferring glycosyl groups
A1s21155_RS03750	COG1560	Kdo2-lipid A biosynthetic process
A1s21155_RS03755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A1s21155_RS03770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A1s21155_RS03800	COG2233	PERMEase
A1s21155_RS03810	COG0697	spore germination
A1s21155_RS03820	COG3938	Belongs to the proline racemase family
A1s21155_RS03825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A1s21155_RS03840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A1s21155_RS03845	COG0537	adenosine 5'-monophosphoramidase activity
A1s21155_RS03860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A1s21155_RS03865	COG1228	amidohydrolase
A1s21155_RS03870	COG2986	histidine ammonia-lyase
A1s21155_RS03885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A1s21155_RS03895	COG1845	cytochrome c oxidase, subunit III
A1s21155_RS03900	COG2010	Cytochrome c
A1s21155_RS03905	COG0723	plastoquinol--plastocyanin reductase activity
A1s21155_RS03910	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A1s21155_RS03915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A1s21155_RS03930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A1s21155_RS03945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1s21155_RS03955	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A1s21155_RS03965	COG0667	Aldo Keto reductase
A1s21155_RS03975	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A1s21155_RS03980	COG3845	ABC transporter
A1s21155_RS03990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A1s21155_RS03995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A1s21155_RS04000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1s21155_RS04005	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1s21155_RS04010	COG1090	epimerase
A1s21155_RS04015	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A1s21155_RS04020	COG0673	inositol 2-dehydrogenase activity
A1s21155_RS04025	COG2409	Drug exporters of the RND superfamily
A1s21155_RS04030	COG0321	lipoyl(octanoyl) transferase activity
A1s21155_RS04035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A1s21155_RS04055	COG0174	glutamine synthetase
A1s21155_RS04060	COG1309	transcriptional regulator
A1s21155_RS04085	COG1024	Enoyl-CoA hydratase
A1s21155_RS04090	COG1260	myo-inositol-1-phosphate synthase
A1s21155_RS04120	COG1940	carbohydrate kinase activity
A1s21155_RS04145	COG0438	transferase activity, transferring glycosyl groups
A1s21155_RS04150	COG0791	NLP P60 protein
A1s21155_RS04175	COG0672	)-iron permease
A1s21155_RS04180	COG0183	Belongs to the thiolase family
A1s21155_RS04185	COG1250	3-hydroxyacyl-CoA dehydrogenase
A1s21155_RS04185	COG1024	Enoyl-CoA hydratase
A1s21155_RS04190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A1s21155_RS04195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A1s21155_RS04200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A1s21155_RS04205	COG0569	domain protein
A1s21155_RS04220	COG0756	dUTP diphosphatase activity
A1s21155_RS04240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A1s21155_RS04245	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A1s21155_RS04250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A1s21155_RS04255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A1s21155_RS04265	COG0336	Belongs to the RNA methyltransferase TrmD family
A1s21155_RS04270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A1s21155_RS04275	COG1837	Belongs to the UPF0109 family
A1s21155_RS04280	COG0228	four-way junction DNA binding
A1s21155_RS04290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A1s21155_RS04315	COG0571	ribonuclease III activity
A1s21155_RS04320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A1s21155_RS04335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A1s21155_RS04340	COG0742	ribosomal rna small subunit methyltransferase
A1s21155_RS04350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A1s21155_RS04365	COG1181	Belongs to the D-alanine--D-alanine ligase family
A1s21155_RS04370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A1s21155_RS04380	COG0776	regulation of translation
A1s21155_RS04385	COG0066	3-isopropylmalate dehydratase activity
A1s21155_RS04390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A1s21155_RS04400	COG2137	regulation of response to DNA damage stimulus
A1s21155_RS04405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A1s21155_RS04430	COG1396	sequence-specific DNA binding
A1s21155_RS04435	COG1058	Belongs to the CinA family
A1s21155_RS04435	COG1546	Belongs to the CinA family
A1s21155_RS04445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A1s21155_RS04455	COG1674	ftsk spoiiie
A1s21155_RS04465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A1s21155_RS04470	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A1s21155_RS04490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A1s21155_RS04495	COG0612	Peptidase, M16
A1s21155_RS04500	COG1185	polyribonucleotide nucleotidyltransferase activity
A1s21155_RS04515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A1s21155_RS04520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A1s21155_RS04525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A1s21155_RS04525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A1s21155_RS04535	COG0779	Required for maturation of 30S ribosomal subunits
A1s21155_RS04540	COG0730	response to heat
A1s21155_RS04545	COG0442	prolyl-tRNA aminoacylation
A1s21155_RS04555	COG0750	zinc metalloprotease
A1s21155_RS04565	COG0395	ABC-type sugar transport system, permease component
A1s21155_RS04570	COG1176	ABC-type spermidine putrescine transport system, permease component I
A1s21155_RS04575	COG3842	ATPase activity
A1s21155_RS04595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A1s21155_RS04605	COG0233	cytoplasmic translational termination
A1s21155_RS04610	COG0528	UMP kinase activity
A1s21155_RS04615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A1s21155_RS04620	COG0052	Belongs to the universal ribosomal protein uS2 family
A1s21155_RS04625	COG4974	Belongs to the 'phage' integrase family
A1s21155_RS04640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A1s21155_RS04650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A1s21155_RS04655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A1s21155_RS04660	COG0440	acetolactate synthase activity
A1s21155_RS04670	COG0129	dihydroxy-acid dehydratase activity
A1s21155_RS04675	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A1s21155_RS04680	COG0154	amidase activity
A1s21155_RS04685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A1s21155_RS04690	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A1s21155_RS04695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A1s21155_RS04700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A1s21155_RS04705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A1s21155_RS04710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A1s21155_RS04715	COG1530	ribonuclease E activity
A1s21155_RS04720	COG0772	Belongs to the SEDS family
A1s21155_RS04740	COG1077	Cell shape determining protein MreB Mrl
A1s21155_RS04745	COG0105	UTP biosynthetic process
A1s21155_RS04755	COG0285	dihydrofolate synthase activity
A1s21155_RS04760	COG0525	valine-tRNA ligase activity
A1s21155_RS04765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A1s21155_RS04775	COG0740	serine-type endopeptidase activity
A1s21155_RS04780	COG0740	serine-type endopeptidase activity
A1s21155_RS04785	COG0544	peptidyl-prolyl cis-trans isomerase activity
A1s21155_RS04810	COG0698	ribose 5-phosphate isomerase
A1s21155_RS04815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A1s21155_RS04835	COG0668	transmembrane transport
A1s21155_RS04845	COG2814	Major facilitator Superfamily
A1s21155_RS04870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A1s21155_RS04895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A1s21155_RS04900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A1s21155_RS04920	COG0366	Alpha amylase catalytic
A1s21155_RS04925	COG0545	Peptidyl-prolyl cis-trans isomerase
A1s21155_RS04930	COG0137	argininosuccinate synthase activity
A1s21155_RS04940	COG5002	protein histidine kinase activity
A1s21155_RS04945	COG0745	RESPONSE REGULATOR receiver
A1s21155_RS04980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A1s21155_RS05005	COG2894	cell division
A1s21155_RS05020	COG0653	protein targeting
A1s21155_RS05025	COG1040	competence protein
A1s21155_RS05030	COG5002	protein histidine kinase activity
A1s21155_RS05035	COG0745	RESPONSE REGULATOR receiver
A1s21155_RS05040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A1s21155_RS05045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A1s21155_RS05080	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A1s21155_RS05085	COG0215	cysteine-tRNA ligase activity
A1s21155_RS05095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A1s21155_RS05115	COG0513	Belongs to the DEAD box helicase family
A1s21155_RS05120	COG2095	MarC family integral membrane protein
A1s21155_RS05125	COG0613	PHP domain protein
A1s21155_RS05135	COG2239	Acts as a magnesium transporter
A1s21155_RS05145	COG0489	protein tyrosine kinase activity
A1s21155_RS05145	COG2151	metal-sulfur cluster biosynthetic enzyme
A1s21155_RS05150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A1s21155_RS05155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1s21155_RS05165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A1s21155_RS05185	COG1611	Belongs to the LOG family
A1s21155_RS05190	COG2171	N-acyltransferase activity
A1s21155_RS05215	COG1316	TRANSCRIPTIONal
A1s21155_RS05220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A1s21155_RS05225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A1s21155_RS05240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A1s21155_RS05250	COG0424	maF-like protein
A1s21155_RS05255	COG4770	biotin carboxylase activity
A1s21155_RS05265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A1s21155_RS05270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A1s21155_RS05275	COG1012	belongs to the aldehyde dehydrogenase family
A1s21155_RS05280	COG1012	belongs to the aldehyde dehydrogenase family
A1s21155_RS05285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A1s21155_RS05300	COG1079	Belongs to the binding-protein-dependent transport system permease family
A1s21155_RS05305	COG4603	Belongs to the binding-protein-dependent transport system permease family
A1s21155_RS05310	COG3845	ABC transporter
A1s21155_RS05315	COG1744	ABC transporter substrate-binding protein PnrA-like
A1s21155_RS05320	COG1744	ABC transporter substrate-binding protein PnrA-like
A1s21155_RS05325	COG0180	Tryptophanyl-tRNA synthetase
A1s21155_RS05330	COG1253	flavin adenine dinucleotide binding
A1s21155_RS05335	COG3842	ATPase activity
A1s21155_RS05345	COG0538	isocitrate dehydrogenase activity
A1s21155_RS05350	COG0039	L-malate dehydrogenase activity
A1s21155_RS05360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A1s21155_RS05385	COG0045	succinate-CoA ligase (ADP-forming) activity
A1s21155_RS05395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A1s21155_RS05400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A1s21155_RS05405	COG0519	Catalyzes the synthesis of GMP from XMP
A1s21155_RS05405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A1s21155_RS05410	COG0516	GMP reductase activity
A1s21155_RS05435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A1s21155_RS05440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A1s21155_RS05445	COG0456	acetyltransferase
A1s21155_RS05445	COG1214	PFAM Peptidase M22, glycoprotease
A1s21155_RS05450	COG1214	PFAM Peptidase M22, glycoprotease
A1s21155_RS05450	COG0456	acetyltransferase
A1s21155_RS05455	COG0802	atpase or kinase
A1s21155_RS05475	COG0559	Belongs to the binding-protein-dependent transport system permease family
A1s21155_RS05490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A1s21155_RS05495	COG0736	holo-[acyl-carrier-protein] synthase activity
A1s21155_RS05505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A1s21155_RS05510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A1s21155_RS05515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A1s21155_RS05520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A1s21155_RS05530	COG0101	tRNA pseudouridine synthase activity
A1s21155_RS05535	COG0203	ribosomal protein L17
A1s21155_RS05540	COG0202	RNA polymerase activity
A1s21155_RS05545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A1s21155_RS05550	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A1s21155_RS05555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A1s21155_RS05560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A1s21155_RS05565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A1s21155_RS05590	COG0024	Methionine aminopeptidase
A1s21155_RS05595	COG0563	adenylate kinase activity
A1s21155_RS05605	COG0200	Binds to the 23S rRNA
A1s21155_RS05610	COG1841	ribosomal large subunit assembly
A1s21155_RS05615	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A1s21155_RS05625	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A1s21155_RS05630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A1s21155_RS05635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A1s21155_RS05640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A1s21155_RS05645	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A1s21155_RS05650	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A1s21155_RS05655	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A1s21155_RS05660	COG0255	Belongs to the universal ribosomal protein uL29 family
A1s21155_RS05665	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A1s21155_RS05670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A1s21155_RS05675	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A1s21155_RS05680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A1s21155_RS05690	COG0089	rRNA binding
A1s21155_RS05695	COG0088	Forms part of the polypeptide exit tunnel
A1s21155_RS05700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A1s21155_RS05705	COG0051	transcription antitermination factor activity, RNA binding
A1s21155_RS05710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A1s21155_RS05715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A1s21155_RS05720	COG0049	tRNA binding
A1s21155_RS05725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A1s21155_RS05735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A1s21155_RS05740	COG0085	RNA polymerase activity
A1s21155_RS05745	COG0222	ribosome binding
A1s21155_RS05750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A1s21155_RS05755	COG0081	regulation of translation
A1s21155_RS05760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A1s21155_RS05770	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A1s21155_RS05780	COG0436	Aminotransferase
A1s21155_RS05785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A1s21155_RS05790	COG0215	cysteine-tRNA ligase activity
A1s21155_RS05800	COG2030	dehydratase
A1s21155_RS05805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A1s21155_RS05830	COG1832	CoA-binding protein
A1s21155_RS05835	COG0395	ABC-type sugar transport system, permease component
A1s21155_RS05850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A1s21155_RS05860	COG4948	Mandelate Racemase Muconate Lactonizing
A1s21155_RS05895	COG1129	ABC transporter
A1s21155_RS05900	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1s21155_RS05910	COG1126	abc transporter atp-binding protein
A1s21155_RS05915	COG0765	amino acid transport
A1s21155_RS05920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1s21155_RS05930	COG1666	GTP binding
A1s21155_RS05940	COG0142	geranyltranstransferase activity
A1s21155_RS05965	COG0839	Belongs to the complex I subunit 6 family
A1s21155_RS05970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1s21155_RS05975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A1s21155_RS05980	COG1034	ATP synthesis coupled electron transport
A1s21155_RS05985	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A1s21155_RS05995	COG0649	NAD binding
A1s21155_RS06000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1s21155_RS06015	COG2226	methyltransferase
A1s21155_RS06020	COG1268	BioY protein
A1s21155_RS06025	COG1169	isochorismate synthase
A1s21155_RS06030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A1s21155_RS06035	COG4948	Mandelate Racemase Muconate Lactonizing
A1s21155_RS06040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A1s21155_RS06065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A1s21155_RS06070	COG1333	cytochrome c biogenesis protein
A1s21155_RS06075	COG0785	Cytochrome C biogenesis protein
A1s21155_RS06080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1s21155_RS06085	COG0406	alpha-ribazole phosphatase activity
A1s21155_RS06105	COG1061	Type III restriction enzyme res subunit
A1s21155_RS06135	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A1s21155_RS06140	COG1194	a g-specific adenine glycosylase
A1s21155_RS06150	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A1s21155_RS06155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A1s21155_RS06160	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A1s21155_RS06170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A1s21155_RS06175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A1s21155_RS06180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A1s21155_RS06190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A1s21155_RS06195	COG0302	gtp cyclohydrolase
A1s21155_RS06210	COG0037	tRNA processing
A1s21155_RS06235	COG0109	protoheme IX farnesyltransferase activity
A1s21155_RS06245	COG2027	D-alanyl-D-alanine carboxypeptidase
A1s21155_RS06265	COG0310	cobalt ion transport
A1s21155_RS06275	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A1s21155_RS06280	COG1122	ATPase activity
A1s21155_RS06305	COG0110	maltose O-acetyltransferase activity
A1s21155_RS06320	COG0009	L-threonylcarbamoyladenylate synthase
A1s21155_RS06350	COG1872	DUF167
A1s21155_RS06360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A1s21155_RS06400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A1s21155_RS06405	COG0047	phosphoribosylformylglycinamidine synthase activity
A1s21155_RS06410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A1s21155_RS06415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A1s21155_RS06420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A1s21155_RS06425	COG0151	Belongs to the GarS family
A1s21155_RS06430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A1s21155_RS06435	COG0191	fructose-bisphosphate aldolase activity
A1s21155_RS06440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A1s21155_RS06465	COG0251	oxidation-reduction process
A1s21155_RS06470	COG1610	YqeY-like protein
A1s21155_RS06480	COG0275	rRNA processing
A1s21155_RS06495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A1s21155_RS06525	COG0531	amino acid
A1s21155_RS06540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A1s21155_RS06550	COG0586	Pfam SNARE associated Golgi protein
A1s21155_RS06560	COG0488	(ABC) transporter
A1s21155_RS06570	COG3483	tryptophan 2,3-dioxygenase activity
A1s21155_RS06580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A1s21155_RS06585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A1s21155_RS06610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A1s21155_RS06630	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A1s21155_RS06635	COG0456	acetyltransferase
A1s21155_RS06640	COG0191	fructose-bisphosphate aldolase activity
A1s21155_RS06650	COG0395	ABC-type sugar transport system, permease component
A1s21155_RS06670	COG1940	carbohydrate kinase activity
A1s21155_RS06685	COG0737	Belongs to the 5'-nucleotidase family
A1s21155_RS06685	COG1525	nuclease
A1s21155_RS06685	COG4085	toxin activity
A1s21155_RS06710	COG1012	belongs to the aldehyde dehydrogenase family
A1s21155_RS06715	COG0006	proline dipeptidase activity
A1s21155_RS06720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A1s21155_RS06725	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A1s21155_RS06730	COG1950	PFAM Membrane protein of
A1s21155_RS06735	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A1s21155_RS06740	COG1053	succinate dehydrogenase
A1s21155_RS06755	COG0561	phosphatase activity
A1s21155_RS06760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A1s21155_RS06780	COG0515	serine threonine protein kinase
A1s21155_RS06805	COG3408	Glycogen debranching enzyme
A1s21155_RS06810	COG0395	ABC-type sugar transport system, permease component
A1s21155_RS06815	COG1175	transmembrane transport
A1s21155_RS06830	COG1609	Transcriptional regulator
A1s21155_RS06835	COG3254	rhamnose metabolic process
A1s21155_RS06845	COG3347	Dehydrogenase
A1s21155_RS06845	COG1028	Short-chain dehydrogenase reductase Sdr
A1s21155_RS06850	COG1070	Carbohydrate kinase
A1s21155_RS06855	COG2181	nitrate reductase activity
A1s21155_RS06855	COG0247	lactate metabolic process
A1s21155_RS06860	COG0705	Rhomboid family
A1s21155_RS06860	COG0457	Tetratricopeptide repeat
A1s21155_RS06880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A1s21155_RS06885	COG0187	DNA topoisomerase II activity
A1s21155_RS06890	COG0745	RESPONSE REGULATOR receiver
A1s21155_RS06895	COG2205	protein histidine kinase activity
A1s21155_RS06900	COG0501	Belongs to the peptidase M48B family
A1s21155_RS06905	COG1704	LemA family
A1s21155_RS06910	COG0717	Belongs to the dCTP deaminase family
A1s21155_RS06915	COG1960	acyl-CoA dehydrogenase activity
A1s21155_RS06925	COG0305	Participates in initiation and elongation during chromosome replication
A1s21155_RS06930	COG0598	Magnesium transport protein CorA
A1s21155_RS06935	COG0359	binds to the 23S rRNA
A1s21155_RS06940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A1s21155_RS06945	COG0629	single-stranded DNA binding
A1s21155_RS06950	COG0360	Binds together with S18 to 16S ribosomal RNA
A1s21155_RS06960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A1s21155_RS06975	COG0617	tRNA 3'-terminal CCA addition
A1s21155_RS06995	COG0492	ferredoxin-NADP+ reductase activity
A1s21155_RS07000	COG3118	belongs to the thioredoxin family
A1s21155_RS07010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1s21155_RS07020	COG1192	Involved in chromosome partitioning
A1s21155_RS07025	COG0357	Ribosomal RNA small subunit methyltransferase G
A1s21155_RS07035	COG0706	membrane insertase activity
A1s21155_RS07040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A1s21155_RS07045	COG0594	ribonuclease P activity
A1s21155_RS07050	COG0230	Belongs to the bacterial ribosomal protein bL34 family