locus-tag	class	description
GWK75_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
GWK75_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
GWK75_RS00110	ENOG41081UC	Inherit from COG: Competence protein
GWK75_RS00160	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
GWK75_RS00170	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
GWK75_RS00185	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
GWK75_RS00210	ENOG41086CI	Bifunctional phosphoglucose phosphomannose isomerase
GWK75_RS00215	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GWK75_RS00220	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GWK75_RS00250	ENOG4108IUX	(ABC) transporter
GWK75_RS00265	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
GWK75_RS00270	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
GWK75_RS00280	ENOG4105C75	arginyL-tRNA synthetase
GWK75_RS00290	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
GWK75_RS00295	ENOG4105UNS	Pfam:DUF419
GWK75_RS00305	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
GWK75_RS00320	ENOG4105C2M	dna polymerase I
GWK75_RS00325	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
GWK75_RS00350	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
GWK75_RS00355	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
GWK75_RS00365	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
GWK75_RS00375	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
GWK75_RS00385	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
GWK75_RS00395	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
GWK75_RS00405	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
GWK75_RS00415	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
GWK75_RS00420	ENOG4105CN5	Metallo-Beta-Lactamase
GWK75_RS00425	ENOG4105CNU	cell division protein FtsK
GWK75_RS00430	ENOG4105CQC	Prephenate dehydratase
GWK75_RS00435	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
GWK75_RS00445	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
GWK75_RS00450	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
GWK75_RS00455	ENOG4105DX0	Hemolysin A
GWK75_RS00460	ENOG4105C3G	gtp-binding protein
GWK75_RS00495	ENOG4107QHF	type ii secretion system protein e
GWK75_RS00500	ENOG4105CZX	twitching motility protein
GWK75_RS00540	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
GWK75_RS00545	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
GWK75_RS00600	ENOG4105C22	threonyL-tRNA synthetase
GWK75_RS00605	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
GWK75_RS00625	ENOG4105KDC	50s ribosomal protein l28
GWK75_RS00630	ENOG4108Z4T	Peptidase M50
GWK75_RS00640	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
GWK75_RS00650	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
GWK75_RS00655	ENOG4105C0P	Mg chelatase subunit ChlI
GWK75_RS00695	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
GWK75_RS00700	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
GWK75_RS00765	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
GWK75_RS00770	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
GWK75_RS00795	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
GWK75_RS00800	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
GWK75_RS00805	ENOG4105C25	Primosomal protein n'
GWK75_RS00820	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
GWK75_RS00840	ENOG4105KTH	gatB Yqey
GWK75_RS00845	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
GWK75_RS00850	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
GWK75_RS00855	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
GWK75_RS00860	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
GWK75_RS00880	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
GWK75_RS00885	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
GWK75_RS00895	ENOG41067S9	phage shock protein C, PspC
GWK75_RS00905	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
GWK75_RS00910	ENOG4107QJE	Chromosome Partitioning Protein
GWK75_RS00915	ENOG4105FA0	parb-like partition protein
GWK75_RS00925	ENOG4107TB5	TRANSCRIPTIONal
GWK75_RS00940	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
GWK75_RS00945	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
GWK75_RS00950	ENOG4105VFB	Binds the 23S rRNA (By similarity)
GWK75_RS00955	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
GWK75_RS00965	ENOG4105CE9	30S ribosomal protein S2
GWK75_RS00970	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
GWK75_RS00975	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
GWK75_RS00980	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
GWK75_RS00995	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
GWK75_RS01000	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
GWK75_RS01010	ENOG4105CRK	lysyL-tRNA synthetase
GWK75_RS01020	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
GWK75_RS01025	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
GWK75_RS01030	ENOG4107R34	abc transporter permease protein
GWK75_RS01040	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
GWK75_RS01045	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
GWK75_RS01055	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
GWK75_RS01065	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
GWK75_RS01075	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
GWK75_RS01080	ENOG41085FR	LemA family
GWK75_RS01090	ENOG4105CAK	Cell division ATP-binding protein ftsE
GWK75_RS01095	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
GWK75_RS01105	ENOG4105CN1	protease
GWK75_RS01110	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
GWK75_RS01120	ENOG4105K46	50S ribosomal protein l27
GWK75_RS01135	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
GWK75_RS01160	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
GWK75_RS01165	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
GWK75_RS01210	ENOG4105CRK	lysyL-tRNA synthetase
GWK75_RS01235	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
GWK75_RS01245	ENOG4107QUV	Domain protein
GWK75_RS01275	ENOG4105CHW	UPF0052 protein
GWK75_RS01280	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
GWK75_RS01290	ENOG4105CJN	penicillin-binding protein
GWK75_RS01295	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
GWK75_RS01300	ENOG4105CNI	cell division protein FtsW
GWK75_RS01305	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
GWK75_RS01340	ENOG4105WKZ	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
GWK75_RS01365	ENOG4107SFZ	crispr-associated protein
GWK75_RS01420	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
GWK75_RS01470	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
GWK75_RS01475	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
GWK75_RS01490	ENOG4105CNI	cell division protein FtsW
GWK75_RS01505	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
GWK75_RS01565	ENOG4108NJY	Repeat protein
GWK75_RS01600	ENOG4105WKZ	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
GWK75_RS01610	ENOG4107SFZ	crispr-associated protein
GWK75_RS01650	ENOG4105C79	DNA protecting protein DprA
GWK75_RS01660	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
GWK75_RS01675	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
GWK75_RS01705	ENOG4105FE9	pseudouridine synthase
GWK75_RS01710	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
GWK75_RS01715	ENOG4105BZU	Histidine kinase
GWK75_RS01720	ENOG4105D0M	Protease HtpX homolog
GWK75_RS01785	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GWK75_RS01790	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
GWK75_RS01795	ENOG4105BZU	Histidine kinase
GWK75_RS01800	ENOG4108R5T	secreted protein
GWK75_RS01850	ENOG4105CGK	Exodeoxyribonuclease III
GWK75_RS01860	ENOG4105CAT	Cytidine monophosphate kinase
GWK75_RS01875	ENOG4105JNK	Glycosyl transferase (Group 1
GWK75_RS01880	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
GWK75_RS01890	ENOG4105C5H	ABC transporter
GWK75_RS01925	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
GWK75_RS01930	ENOG4107YZM	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
GWK75_RS01935	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
GWK75_RS01940	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
GWK75_RS01950	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
GWK75_RS01955	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
GWK75_RS01975	ENOG4108VAU	general secretion pathway protein G
GWK75_RS01980	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
GWK75_RS01985	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
GWK75_RS01990	ENOG4107QRI	Phosphoketolase
GWK75_RS02025	ENOG4105DSF	transport protein
GWK75_RS02030	ENOG4105C8N	cysteinyl-tRNA synthetase
GWK75_RS02045	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
GWK75_RS02050	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
GWK75_RS02060	ENOG4105CDU	Replicative dna helicase
GWK75_RS02065	ENOG4105C6E	dna polymerase iii
GWK75_RS02070	ENOG4107104	thymidine kinase
GWK75_RS02085	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
GWK75_RS02090	ENOG4108VZM	50s ribosomal protein L10
GWK75_RS02100	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
GWK75_RS02110	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
GWK75_RS02115	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
GWK75_RS02130	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
GWK75_RS02135	ENOG41068JE	domain protein
GWK75_RS02170	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
GWK75_RS02180	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
GWK75_RS02190	ENOG4105BZU	Histidine kinase
GWK75_RS02225	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
GWK75_RS02245	ENOG4105W0E	50S ribosomal protein L33
GWK75_RS02250	ENOG4108VPT	UPF0234 protein
GWK75_RS02265	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
GWK75_RS02315	ENOG4105C34	Pseudouridine synthase
GWK75_RS02320	ENOG4105C31	Tryptophanyl-tRNA synthetase
GWK75_RS02325	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
GWK75_RS02330	ENOG4108UJD	30S ribosomal protein S9
GWK75_RS02335	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
GWK75_RS02340	ENOG4108ZT0	50S ribosomal protein l17
GWK75_RS02345	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GWK75_RS02350	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
GWK75_RS02355	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
GWK75_RS02385	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
GWK75_RS02390	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
GWK75_RS02395	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
GWK75_RS02400	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
GWK75_RS02410	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
GWK75_RS02415	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
GWK75_RS02420	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWK75_RS02425	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
GWK75_RS02440	ENOG41082SA	50s ribosomal protein l29
GWK75_RS02445	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
GWK75_RS02465	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWK75_RS02470	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
GWK75_RS02475	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
GWK75_RS02480	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
GWK75_RS02495	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
GWK75_RS02505	ENOG4105C5B	carbamate kinase
GWK75_RS02510	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
GWK75_RS02525	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
GWK75_RS02530	ENOG4105CMR	udp-glucose 4-epimerase
GWK75_RS02555	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
GWK75_RS02580	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
GWK75_RS02585	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
GWK75_RS02600	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GWK75_RS02605	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GWK75_RS02615	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
GWK75_RS02620	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
GWK75_RS02655	ENOG4105CQB	FAD linked oxidase domain protein
GWK75_RS02675	ENOG4106H78	methyltransferase
GWK75_RS02695	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
GWK75_RS02700	ENOG4105BZ4	penicillin-binding protein
GWK75_RS02705	ENOG4105CTP	PilT protein domain protein
GWK75_RS02710	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
GWK75_RS02720	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
GWK75_RS02725	ENOG4105CHV	Transcription elongation factor NusA
GWK75_RS02735	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
GWK75_RS02760	ENOG4105CD8	aminopeptidase N
GWK75_RS02765	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
GWK75_RS02770	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
GWK75_RS02775	ENOG4105C6K	Malic enzyme
GWK75_RS02780	ENOG4107QHF	type ii secretion system protein e
GWK75_RS02790	ENOG4105C0B	DNA polymerase III (alpha subunit)
GWK75_RS02840	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
GWK75_RS02845	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
GWK75_RS02850	ENOG4107R91	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
GWK75_RS02855	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
GWK75_RS02860	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
GWK75_RS02875	ENOG4107Y7Q	pfkb domain protein
GWK75_RS02880	ENOG4105D2N	Aldolase
GWK75_RS02890	ENOG4105CV1	Transketolase (EC 2.2.1.1)
GWK75_RS02905	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
GWK75_RS02910	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
GWK75_RS02920	ENOG4105F0N	pyrophosphate phospho-hydrolase
GWK75_RS02930	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
GWK75_RS02935	ENOG4105C3M	thioredoxin reductase
GWK75_RS02945	ENOG4105BZ1	(ABC) transporter
GWK75_RS02960	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
GWK75_RS02965	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
GWK75_RS02980	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
GWK75_RS03015	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
GWK75_RS03025	ENOG4105CUT	histidyl-tRNA synthetase
GWK75_RS03060	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
GWK75_RS03070	ENOG41084QK	UPF0109 protein
GWK75_RS03085	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
GWK75_RS03095	ENOG4105M7K	Involved in the transcription termination process (By similarity)
GWK75_RS03105	ENOG4105C8T	Leucyl-tRNA synthetase
GWK75_RS03115	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
GWK75_RS03130	ENOG4105E5Q	amino acid AbC transporter
GWK75_RS03135	ENOG4108HW3	(ABC) transporter
GWK75_RS03145	ENOG4105EU2	peptidase U61 LD-carboxypeptidase A
GWK75_RS03260	ENOG4105CJ1	ABC, transporter
GWK75_RS03280	ENOG4107QX8	SPFH domain, Band 7 family protein
GWK75_RS03285	ENOG4105CPF	Cell wall formation (By similarity)
GWK75_RS03300	ENOG4105CG3	alpha amylase, catalytic region
GWK75_RS03310	ENOG4105CI3	gtp-binding protein typa
GWK75_RS03325	ENOG4105VFU	Rna-binding protein
GWK75_RS03335	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
GWK75_RS03380	ENOG41086DT	Membrane protein of unknown function
GWK75_RS03385	ENOG4107RAQ	aminopeptidase
GWK75_RS03400	ENOG4105K63	Thioredoxin
GWK75_RS03420	ENOG4105BZ1	(ABC) transporter
GWK75_RS03425	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
GWK75_RS03430	ENOG4105DQR	SNARE associated Golgi
GWK75_RS03435	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
GWK75_RS03445	ENOG4105CJB	Exodeoxyribonuclease I
GWK75_RS03460	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWK75_RS03465	ENOG41068JE	domain protein
GWK75_RS03475	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
GWK75_RS03485	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
GWK75_RS03495	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
GWK75_RS03530	ENOG4105F8V	Hydrolase, tatD family
GWK75_RS03535	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
GWK75_RS03550	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
GWK75_RS03570	ENOG4105CP7	Triose-phosphate isomerase
GWK75_RS03575	ENOG4105BZA	Phosphoglycerate kinase
GWK75_RS03655	ENOG4108Z03	MAF-like protein
GWK75_RS03670	ENOG4105RHY	Pfam:UPF0157
GWK75_RS03675	ENOG4105BZU	Histidine kinase
GWK75_RS03680	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
GWK75_RS03710	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
GWK75_RS03715	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
GWK75_RS03740	ENOG4105BZU	Histidine kinase
GWK75_RS03750	ENOG4108MGY	Histidine kinase
GWK75_RS03755	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
GWK75_RS03775	ENOG4107XGT	Cell wall formation (By similarity)
GWK75_RS03780	ENOG4105VWV	general secretion pathway protein h
GWK75_RS03805	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
GWK75_RS03845	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
GWK75_RS03855	ENOG4105DMS	mur ligase
GWK75_RS03885	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
GWK75_RS03890	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
GWK75_RS03900	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
GWK75_RS03910	ENOG41072GX	Peptidase M22 Glycoprotease
GWK75_RS03915	ENOG4108097	ATP-binding protein
GWK75_RS03920	ENOG4107QHF	type ii secretion system protein e
GWK75_RS03955	ENOG4105KC9	Modulates RecA activity (By similarity)
GWK75_RS03970	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
GWK75_RS03975	ENOG4106855	Competence protein
GWK75_RS03985	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
GWK75_RS03995	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
GWK75_RS04000	ENOG4105BZ4	penicillin-binding protein
GWK75_RS04005	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
GWK75_RS04020	ENOG4105CDY	transcriptional regulatory protein
GWK75_RS04045	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
GWK75_RS04100	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
GWK75_RS04110	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
GWK75_RS04120	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
GWK75_RS04135	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
GWK75_RS04160	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
GWK75_RS04175	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
GWK75_RS04185	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GWK75_RS04190	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
GWK75_RS04200	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
GWK75_RS04240	ENOG4107QN2	dihydrolipoyl dehydrogenase
GWK75_RS04285	ENOG4105DFU	Cell wall formation (By similarity)
GWK75_RS04290	ENOG4105FEU	K -dependent Na -Ca exchanger
GWK75_RS04300	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
GWK75_RS04305	ENOG4105D8X	mechanosensitive ion channel
GWK75_RS04320	ENOG4105C9M	aspartyl-trna synthetase
GWK75_RS04330	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
GWK75_RS04335	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GWK75_RS04360	ENOG4105K7K	Transcriptional regulator
GWK75_RS04365	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
GWK75_RS04370	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GWK75_RS04385	ENOG4105VZ9	UPF0235 protein
GWK75_RS04390	ENOG41067QW	Transcriptional regulator
GWK75_RS04395	ENOG4105DZR	Type I site-specific deoxyribonuclease
GWK75_RS04415	ENOG4105EKX	Restriction modification system DNA (Specificity
GWK75_RS04430	ENOG4105CVR	type I restriction-modification system
GWK75_RS04435	ENOG4105W5Q	DNA repair protein (RadC
GWK75_RS04440	ENOG41062D9	Histidine kinase
GWK75_RS04490	ENOG4108PJD	permease
GWK75_RS04495	ENOG4105M6F	mutator MutT protein
GWK75_RS04525	ENOG4105D3Q	Sugar transferase
GWK75_RS04585	ENOG4105CKK	Glycosyl transferase, family 2
GWK75_RS04620	ENOG4105EY8	ABC transporter
GWK75_RS04625	ENOG4105MFV	ABC-2 type transporter
GWK75_RS04635	ENOG4108TJN	glycosyl transferase group 1
GWK75_RS04640	ENOG4108DMA	Nad-dependent epimerase dehydratase
GWK75_RS04645	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
GWK75_RS04650	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
GWK75_RS04655	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
GWK75_RS04675	ENOG4108TJN	glycosyl transferase group 1
GWK75_RS04685	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
GWK75_RS04695	ENOG4105VG0	50S ribosomal protein l34