locus-tag	class	description
HW277_RS00010	COG0592	DNA-directed DNA polymerase activity
HW277_RS00100	COG0071	Belongs to the small heat shock protein (HSP20) family
HW277_RS00110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HW277_RS00155	COG0525	valine-tRNA ligase activity
HW277_RS00165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HW277_RS00215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW277_RS00220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HW277_RS00225	COG0459	protein refolding
HW277_RS00245	COG2222	sugar isomerase
HW277_RS00250	COG0577	efflux transmembrane transporter activity
HW277_RS00280	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW277_RS00315	COG0504	CTP synthase activity
HW277_RS00325	COG0018	arginyl-trna synthetase
HW277_RS00340	COG0528	UMP kinase activity
HW277_RS00345	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HW277_RS00350	COG2315	Protein conserved in bacteria
HW277_RS00360	COG0358	DNA primase activity
HW277_RS00365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW277_RS00380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW277_RS00380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW277_RS00390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HW277_RS00415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HW277_RS00420	COG2165	general secretion pathway protein
HW277_RS00425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HW277_RS00445	COG1185	polyribonucleotide nucleotidyltransferase activity
HW277_RS00455	COG1573	uracil-dna glycosylase
HW277_RS00460	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW277_RS00480	COG0360	Binds together with S18 to 16S ribosomal RNA
HW277_RS00485	COG0629	single-stranded DNA binding
HW277_RS00490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HW277_RS00495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HW277_RS00500	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HW277_RS00545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW277_RS00560	COG4969	Belongs to the N-Me-Phe pilin family
HW277_RS00635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW277_RS00645	COG3695	enzyme binding
HW277_RS00650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HW277_RS00665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW277_RS00670	COG1994	Peptidase M50
HW277_RS00680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HW277_RS00685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HW277_RS00695	COG0606	chelatase, subunit chli
HW277_RS00730	COG0187	DNA topoisomerase II activity
HW277_RS00735	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW277_RS00775	COG0167	dihydroorotate dehydrogenase activity
HW277_RS00815	COG0539	negative regulation of cytoplasmic translation
HW277_RS00820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HW277_RS00820	COG3170	Tfp pilus assembly protein FimV
HW277_RS00840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HW277_RS00845	COG0242	peptide deformylase activity
HW277_RS00850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HW277_RS00860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HW277_RS00860	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HW277_RS00875	COG1610	YqeY-like protein
HW277_RS00895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW277_RS00900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW277_RS00945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HW277_RS00970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HW277_RS00975	COG1192	Involved in chromosome partitioning
HW277_RS00980	COG1475	DNA binding
HW277_RS01000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW277_RS01005	COG2890	protein-(glutamine-N5) methyltransferase activity
HW277_RS01015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HW277_RS01025	COG0254	rRNA binding
HW277_RS01035	COG0052	Belongs to the universal ribosomal protein uS2 family
HW277_RS01040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HW277_RS01045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW277_RS01055	COG0233	cytoplasmic translational termination
HW277_RS01065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HW277_RS01070	COG0750	zinc metalloprotease
HW277_RS01080	COG0442	prolyl-tRNA aminoacylation
HW277_RS01100	COG4535	Mg2 and Co2 transporter CorC
HW277_RS01110	COG1136	(ABC) transporter
HW277_RS01110	COG0577	efflux transmembrane transporter activity
HW277_RS01115	COG1136	(ABC) transporter
HW277_RS01120	COG1695	Transcriptional regulator
HW277_RS01130	COG1968	undecaprenyl-diphosphatase activity
HW277_RS01145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HW277_RS01155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HW277_RS01160	COG0653	protein targeting
HW277_RS01180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HW277_RS01200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW277_RS01210	COG2884	Cell division ATP-binding protein ftsE
HW277_RS01215	COG2177	Part of the ABC transporter FtsEX involved in
HW277_RS01225	COG0793	Belongs to the peptidase S41A family
HW277_RS01230	COG0745	RESPONSE REGULATOR receiver
HW277_RS01235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HW277_RS01255	COG1570	exodeoxyribonuclease VII activity
HW277_RS01265	COG2264	protein methyltransferase activity
HW277_RS01285	COG1381	Involved in DNA repair and RecF pathway recombination
HW277_RS01295	COG0423	glycine-tRNA ligase activity
HW277_RS01340	COG0019	diaminopimelate decarboxylase activity
HW277_RS01350	COG0328	RNA-DNA hybrid ribonuclease activity
HW277_RS01360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW277_RS01365	COG2723	6-phospho-beta-galactosidase activity
HW277_RS01370	COG2001	Belongs to the MraZ family
HW277_RS01375	COG0275	rRNA processing
HW277_RS01390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW277_RS01395	COG0772	Belongs to the SEDS family
HW277_RS01400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW277_RS01435	COG0758	DNA mediated transformation
HW277_RS01460	COG0701	Predicted permease
HW277_RS01470	COG0193	aminoacyl-tRNA hydrolase activity
HW277_RS01490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW277_RS01505	COG1051	belongs to the nudix hydrolase family
HW277_RS01510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HW277_RS01515	COG1136	(ABC) transporter
HW277_RS01545	COG0248	Ppx GppA phosphatase
HW277_RS01565	COG5002	protein histidine kinase activity
HW277_RS01570	COG0745	RESPONSE REGULATOR receiver
HW277_RS01575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW277_RS01580	COG5002	protein histidine kinase activity
HW277_RS01595	COG4152	abc transporter atp-binding protein
HW277_RS01610	COG0215	cysteine-tRNA ligase activity
HW277_RS01625	COG1160	GTP binding
HW277_RS01635	COG1187	pseudouridine synthase activity
HW277_RS01640	COG0745	RESPONSE REGULATOR receiver
HW277_RS01645	COG5002	protein histidine kinase activity
HW277_RS01655	COG1136	(ABC) transporter
HW277_RS01655	COG0577	efflux transmembrane transporter activity
HW277_RS01675	COG0745	RESPONSE REGULATOR receiver
HW277_RS01680	COG5002	protein histidine kinase activity
HW277_RS01685	COG1470	cell adhesion involved in biofilm formation
HW277_RS01690	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HW277_RS01690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HW277_RS01730	COG0494	nUDIX hydrolase
HW277_RS01735	COG1876	peptidase activity
HW277_RS01745	COG0708	Exodeoxyribonuclease III
HW277_RS01760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HW277_RS01815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW277_RS01820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HW277_RS01825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HW277_RS01840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HW277_RS01855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW277_RS01860	COG3177	Filamentation induced by cAMP protein fic
HW277_RS01900	COG1136	(ABC) transporter
HW277_RS01905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HW277_RS01910	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HW277_RS01920	COG0305	Participates in initiation and elongation during chromosome replication
HW277_RS01925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW277_RS01945	COG0222	ribosome binding
HW277_RS01950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HW277_RS01960	COG0081	regulation of translation
HW277_RS01970	COG0148	phosphopyruvate hydratase activity
HW277_RS01975	COG0009	L-threonylcarbamoyladenylate synthase
HW277_RS01980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HW277_RS01990	COG0250	Participates in transcription elongation, termination and antitermination
HW277_RS02000	COG5002	protein histidine kinase activity
HW277_RS02095	COG0470	DNA polymerase III
HW277_RS02100	COG0564	pseudouridine synthase activity
HW277_RS02105	COG0180	Tryptophanyl-tRNA synthetase
HW277_RS02115	COG2267	carboxylic ester hydrolase activity
HW277_RS02125	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HW277_RS02130	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HW277_RS02135	COG0203	ribosomal protein L17
HW277_RS02140	COG0202	RNA polymerase activity
HW277_RS02145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HW277_RS02160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW277_RS02165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW277_RS02180	COG0200	Binds to the 23S rRNA
HW277_RS02185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HW277_RS02190	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HW277_RS02195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HW277_RS02235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HW277_RS02240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW277_RS02245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HW277_RS02250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HW277_RS02255	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HW277_RS02260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HW277_RS02265	COG0255	Belongs to the universal ribosomal protein uL29 family
HW277_RS02270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HW277_RS02275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HW277_RS02280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HW277_RS02285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HW277_RS02290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HW277_RS02295	COG0089	rRNA binding
HW277_RS02300	COG0088	Forms part of the polypeptide exit tunnel
HW277_RS02305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HW277_RS02320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HW277_RS02330	COG1666	GTP binding
HW277_RS02335	COG0049	tRNA binding
HW277_RS02340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HW277_RS02355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HW277_RS02360	COG0085	RNA polymerase activity
HW277_RS02370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW277_RS02380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW277_RS02390	COG0740	serine-type endopeptidase activity
HW277_RS02425	COG0277	FAD linked oxidase domain protein
HW277_RS02455	COG1397	ADP-ribosylglycohydrolase
HW277_RS02460	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HW277_RS02480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW277_RS02490	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW277_RS02495	COG0330	HflC and HflK could
HW277_RS02505	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HW277_RS02540	COG2988	succinylglutamate desuccinylase activity
HW277_RS02555	COG0366	Alpha amylase catalytic
HW277_RS02575	COG0742	ribosomal rna small subunit methyltransferase
HW277_RS02585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW277_RS02595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HW277_RS02600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW277_RS02605	COG4956	integral membrane protein (PIN domain superfamily)
HW277_RS02610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HW277_RS02625	COG0195	Participates in both transcription termination and antitermination
HW277_RS02655	COG0492	ferredoxin-NADP+ reductase activity
HW277_RS02665	COG1132	(ABC) transporter
HW277_RS02670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW277_RS02670	COG0072	phenylalanine-tRNA ligase activity
HW277_RS02710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HW277_RS02745	COG0336	Belongs to the RNA methyltransferase TrmD family
HW277_RS02750	COG1837	Belongs to the UPF0109 family
HW277_RS02755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW277_RS02760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HW277_RS02770	COG0849	cell division
HW277_RS02780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HW277_RS02795	COG0482	sulfurtransferase activity
HW277_RS02805	COG1104	cysteine desulfurase activity
HW277_RS02820	COG0084	hydrolase, TatD family'
HW277_RS02825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW277_RS02860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW277_RS02890	COG0149	triose-phosphate isomerase activity
HW277_RS02895	COG0126	phosphoglycerate kinase activity
HW277_RS02900	COG0469	pyruvate kinase activity
HW277_RS02905	COG0571	ribonuclease III activity
HW277_RS02930	COG0495	leucyl-tRNA aminoacylation
HW277_RS02940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW277_RS02950	COG0280	phosphate acetyltransferase
HW277_RS02965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HW277_RS02980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HW277_RS02990	COG0501	Belongs to the peptidase M48B family
HW277_RS02995	COG1704	LemA family
HW277_RS03005	COG1131	(ABC) transporter
HW277_RS03040	COG0747	negative chemotaxis
HW277_RS03050	COG1950	PFAM Membrane protein of
HW277_RS03060	COG0322	excinuclease ABC activity
HW277_RS03090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW277_RS03100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW277_RS03110	COG0154	amidase activity
HW277_RS03115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW277_RS03130	COG0556	nucleotide-excision repair
HW277_RS03135	COG1611	Belongs to the LOG family
HW277_RS03145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW277_RS03155	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HW277_RS03160	COG3959	Transketolase, thiamine diphosphate binding domain
HW277_RS03170	COG0698	ribose 5-phosphate isomerase
HW277_RS03185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HW277_RS03200	COG0281	malic enzyme
HW277_RS03205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW277_RS03210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW277_RS03225	COG0051	transcription antitermination factor activity, RNA binding
HW277_RS03235	COG0039	L-malate dehydrogenase activity
HW277_RS03240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HW277_RS03250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW277_RS03255	COG0343	queuine tRNA-ribosyltransferase activity
HW277_RS03265	COG1573	uracil-dna glycosylase
HW277_RS03280	COG0242	peptide deformylase activity
HW277_RS03285	COG1132	(ABC) transporter
HW277_RS03290	COG0586	Pfam SNARE associated Golgi protein
HW277_RS03295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HW277_RS03305	COG2925	Exonuclease
HW277_RS03310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HW277_RS03315	COG3942	CHAP domain
HW277_RS03315	COG1388	LysM domain
HW277_RS03340	COG5002	protein histidine kinase activity
HW277_RS03350	COG2204	response regulator
HW277_RS03355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HW277_RS03390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HW277_RS03395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HW277_RS03420	COG4968	Prepilin-type N-terminal cleavage methylation domain
HW277_RS03425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HW277_RS03445	COG0542	response to heat
HW277_RS03490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HW277_RS03505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HW277_RS03510	COG0588	phosphoglycerate mutase activity
HW277_RS03515	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HW277_RS03520	COG1418	mRNA catabolic process
HW277_RS03525	COG1214	PFAM Peptidase M22, glycoprotease
HW277_RS03530	COG0802	atpase or kinase
HW277_RS03560	COG1459	type II secretion system
HW277_RS03585	COG0572	uridine kinase
HW277_RS03590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HW277_RS03595	COG0668	transmembrane transport
HW277_RS03620	COG1194	a g-specific adenine glycosylase
HW277_RS03630	COG0494	nUDIX hydrolase
HW277_RS03635	COG0300	oxidoreductase activity
HW277_RS03645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HW277_RS03650	COG2255	four-way junction helicase activity
HW277_RS03665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW277_RS03670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HW277_RS03685	COG0217	transcriptional regulatory protein
HW277_RS03715	COG0189	ligase activity
HW277_RS03725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW277_RS03745	COG0443	Heat shock 70 kDa protein
HW277_RS03750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HW277_RS03760	COG1420	regulation of RNA biosynthetic process
HW277_RS03770	COG0194	GDP metabolic process
HW277_RS03795	COG0481	GTPase activity
HW277_RS03850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW277_RS03890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW277_RS03895	COG1324	tolerance protein
HW277_RS03995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW277_RS04000	COG2137	regulation of response to DNA damage stimulus
HW277_RS04015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HW277_RS04035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW277_RS04035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HW277_RS04045	COG0477	Major facilitator Superfamily
HW277_RS04065	COG1131	(ABC) transporter
HW277_RS04090	COG1288	antiporter activity
HW277_RS04095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HW277_RS04125	COG1204	response to ionizing radiation
HW277_RS04165	COG0765	amino acid transport
HW277_RS04170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW277_RS04180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW277_RS04195	COG0542	response to heat
HW277_RS04205	COG1136	(ABC) transporter
HW277_RS04225	COG0726	polysaccharide deacetylase
HW277_RS04230	COG1872	DUF167
HW277_RS04280	COG2003	Belongs to the UPF0758 family
HW277_RS04305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW277_RS04305	COG1328	CTP reductase activity
HW277_RS04325	COG1131	(ABC) transporter
HW277_RS04330	COG5002	protein histidine kinase activity
HW277_RS04330	COG3850	Histidine kinase
HW277_RS04355	COG1619	proteins homologs of microcin C7 resistance protein MccF
HW277_RS04360	COG1619	proteins homologs of microcin C7 resistance protein MccF
HW277_RS04380	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HW277_RS04405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HW277_RS04420	COG0438	transferase activity, transferring glycosyl groups
HW277_RS04430	COG0662	Cupin 2, conserved barrel domain protein
HW277_RS04430	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HW277_RS04465	COG1215	transferase activity, transferring glycosyl groups
HW277_RS04515	COG0297	glycogen (starch) synthase activity
HW277_RS04520	COG0438	transferase activity, transferring glycosyl groups
HW277_RS04535	COG0706	membrane insertase activity
HW277_RS04540	COG0594	ribonuclease P activity
HW277_RS04545	COG0230	Belongs to the bacterial ribosomal protein bL34 family