locus-tag	class	description
FBF33_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FBF33_RS00010	COG0592	DNA-directed DNA polymerase activity
FBF33_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FBF33_RS00110	COG1040	competence protein
FBF33_RS00160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FBF33_RS00170	COG0525	valine-tRNA ligase activity
FBF33_RS00185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FBF33_RS00210	COG2222	sugar isomerase
FBF33_RS00215	COG1136	(ABC) transporter
FBF33_RS00215	COG0577	efflux transmembrane transporter activity
FBF33_RS00220	COG0577	efflux transmembrane transporter activity
FBF33_RS00220	COG1136	(ABC) transporter
FBF33_RS00250	COG4152	abc transporter atp-binding protein
FBF33_RS00265	COG0504	CTP synthase activity
FBF33_RS00270	COG0018	arginyl-trna synthetase
FBF33_RS00280	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FBF33_RS00285	COG2315	Protein conserved in bacteria
FBF33_RS00295	COG0358	DNA primase activity
FBF33_RS00310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FBF33_RS00310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FBF33_RS00315	COG0756	dUTP diphosphatase activity
FBF33_RS00340	COG0546	phosphoglycolate phosphatase activity
FBF33_RS00345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FBF33_RS00355	COG0268	Binds directly to 16S ribosomal RNA
FBF33_RS00365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FBF33_RS00375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FBF33_RS00385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FBF33_RS00395	COG1185	polyribonucleotide nucleotidyltransferase activity
FBF33_RS00405	COG1573	uracil-dna glycosylase
FBF33_RS00410	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FBF33_RS00420	COG1605	Chorismate mutase
FBF33_RS00420	COG0077	Prephenate dehydratase
FBF33_RS00425	COG0360	Binds together with S18 to 16S ribosomal RNA
FBF33_RS00435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FBF33_RS00440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FBF33_RS00445	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FBF33_RS00455	COG0012	GTP binding
FBF33_RS00490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FBF33_RS00535	COG4974	Belongs to the 'phage' integrase family
FBF33_RS00590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FBF33_RS00600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FBF33_RS00615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FBF33_RS00620	COG1994	Peptidase M50
FBF33_RS00630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FBF33_RS00640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FBF33_RS00645	COG0606	chelatase, subunit chli
FBF33_RS00685	COG0187	DNA topoisomerase II activity
FBF33_RS00690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FBF33_RS00755	COG0539	negative regulation of cytoplasmic translation
FBF33_RS00760	COG3064	Membrane
FBF33_RS00760	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FBF33_RS00785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FBF33_RS00790	COG0242	peptide deformylase activity
FBF33_RS00795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FBF33_RS00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FBF33_RS00810	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FBF33_RS00825	COG1610	YqeY-like protein
FBF33_RS00830	COG0563	adenylate kinase activity
FBF33_RS00835	COG0024	Methionine aminopeptidase
FBF33_RS00845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FBF33_RS00850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FBF33_RS00865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FBF33_RS00870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FBF33_RS00880	COG1983	PspC domain protein
FBF33_RS00890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FBF33_RS00895	COG1192	Involved in chromosome partitioning
FBF33_RS00900	COG1475	DNA binding
FBF33_RS00910	COG1316	TRANSCRIPTIONal
FBF33_RS00920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FBF33_RS00925	COG2890	protein-(glutamine-N5) methyltransferase activity
FBF33_RS00930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FBF33_RS00935	COG0254	rRNA binding
FBF33_RS00940	COG1051	belongs to the nudix hydrolase family
FBF33_RS00950	COG0052	Belongs to the universal ribosomal protein uS2 family
FBF33_RS00955	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FBF33_RS00960	COG0233	cytoplasmic translational termination
FBF33_RS00965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FBF33_RS00980	COG0442	prolyl-tRNA aminoacylation
FBF33_RS00985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FBF33_RS00995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FBF33_RS01005	COG1968	undecaprenyl-diphosphatase activity
FBF33_RS01010	COG1136	(ABC) transporter
FBF33_RS01015	COG0577	efflux transmembrane transporter activity
FBF33_RS01025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FBF33_RS01030	COG0167	dihydroorotate dehydrogenase activity
FBF33_RS01040	COG0653	protein targeting
FBF33_RS01050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FBF33_RS01060	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FBF33_RS01065	COG1704	LemA family
FBF33_RS01075	COG2884	Cell division ATP-binding protein ftsE
FBF33_RS01080	COG2177	Part of the ABC transporter FtsEX involved in
FBF33_RS01090	COG0793	Belongs to the peptidase S41A family
FBF33_RS01095	COG0745	RESPONSE REGULATOR receiver
FBF33_RS01105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FBF33_RS01120	COG1570	exodeoxyribonuclease VII activity
FBF33_RS01150	COG1381	Involved in DNA repair and RecF pathway recombination
FBF33_RS01155	COG0423	glycine-tRNA ligase activity
FBF33_RS01195	COG0328	RNA-DNA hybrid ribonuclease activity
FBF33_RS01200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FBF33_RS01210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FBF33_RS01240	COG2723	6-phospho-beta-galactosidase activity
FBF33_RS01245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FBF33_RS01250	COG0275	rRNA processing
FBF33_RS01265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FBF33_RS01270	COG0772	Belongs to the SEDS family
FBF33_RS01290	COG0494	nUDIX hydrolase
FBF33_RS01310	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FBF33_RS01365	COG0758	DNA mediated transformation
FBF33_RS01375	COG0193	aminoacyl-tRNA hydrolase activity
FBF33_RS01390	COG1160	GTP binding
FBF33_RS01420	COG1187	pseudouridine synthase activity
FBF33_RS01425	COG0745	RESPONSE REGULATOR receiver
FBF33_RS01430	COG5002	protein histidine kinase activity
FBF33_RS01435	COG0501	Belongs to the peptidase M48B family
FBF33_RS01450	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FBF33_RS01465	COG1136	(ABC) transporter
FBF33_RS01470	COG0745	RESPONSE REGULATOR receiver
FBF33_RS01475	COG5002	protein histidine kinase activity
FBF33_RS01480	COG1470	cell adhesion involved in biofilm formation
FBF33_RS01530	COG0708	Exodeoxyribonuclease III
FBF33_RS01555	COG0438	transferase activity, transferring glycosyl groups
FBF33_RS01565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FBF33_RS01575	COG0488	(ABC) transporter
FBF33_RS01600	COG0356	it plays a direct role in the translocation of protons across the membrane
FBF33_RS01620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FBF33_RS01630	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FBF33_RS01635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FBF33_RS01640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FBF33_RS01655	COG2165	general secretion pathway protein
FBF33_RS01660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FBF33_RS01665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FBF33_RS01670	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FBF33_RS01710	COG0215	cysteine-tRNA ligase activity
FBF33_RS01725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FBF33_RS01730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FBF33_RS01740	COG0305	Participates in initiation and elongation during chromosome replication
FBF33_RS01745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FBF33_RS01750	COG1435	thymidine kinase activity
FBF33_RS01765	COG0222	ribosome binding
FBF33_RS01770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FBF33_RS01780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FBF33_RS01795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FBF33_RS01810	COG0081	regulation of translation
FBF33_RS01815	COG3942	CHAP domain
FBF33_RS01850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FBF33_RS01860	COG0250	Participates in transcription elongation, termination and antitermination
FBF33_RS01870	COG5002	protein histidine kinase activity
FBF33_RS01905	COG0438	transferase activity, transferring glycosyl groups
FBF33_RS01925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FBF33_RS01930	COG1666	GTP binding
FBF33_RS01945	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FBF33_RS01990	COG0564	pseudouridine synthase activity
FBF33_RS01995	COG0180	Tryptophanyl-tRNA synthetase
FBF33_RS02000	COG2267	carboxylic ester hydrolase activity
FBF33_RS02005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FBF33_RS02010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FBF33_RS02015	COG0203	ribosomal protein L17
FBF33_RS02020	COG0202	RNA polymerase activity
FBF33_RS02025	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FBF33_RS02030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FBF33_RS02065	COG0200	Binds to the 23S rRNA
FBF33_RS02070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FBF33_RS02075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FBF33_RS02080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FBF33_RS02090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FBF33_RS02095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FBF33_RS02100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FBF33_RS02120	COG0255	Belongs to the universal ribosomal protein uL29 family
FBF33_RS02125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FBF33_RS02140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FBF33_RS02145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FBF33_RS02155	COG0088	Forms part of the polypeptide exit tunnel
FBF33_RS02160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FBF33_RS02175	COG0051	transcription antitermination factor activity, RNA binding
FBF33_RS02185	COG0549	Belongs to the carbamate kinase family
FBF33_RS02190	COG1288	antiporter activity
FBF33_RS02205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FBF33_RS02210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FBF33_RS02225	COG0494	nUDIX hydrolase
FBF33_RS02235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FBF33_RS02260	COG0049	tRNA binding
FBF33_RS02265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FBF33_RS02285	COG0085	RNA polymerase activity
FBF33_RS02295	COG0740	serine-type endopeptidase activity
FBF33_RS02300	COG0544	peptidyl-prolyl cis-trans isomerase activity
FBF33_RS02335	COG0277	FAD linked oxidase domain protein
FBF33_RS02360	COG0742	ribosomal rna small subunit methyltransferase
FBF33_RS02370	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FBF33_RS02380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FBF33_RS02385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FBF33_RS02390	COG4956	integral membrane protein (PIN domain superfamily)
FBF33_RS02395	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FBF33_RS02405	COG0542	response to heat
FBF33_RS02410	COG0195	Participates in both transcription termination and antitermination
FBF33_RS02420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FBF33_RS02430	COG0343	queuine tRNA-ribosyltransferase activity
FBF33_RS02450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FBF33_RS02455	COG0335	large ribosomal subunit rRNA binding
FBF33_RS02460	COG0281	malic enzyme
FBF33_RS02465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FBF33_RS02520	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FBF33_RS02530	COG0154	amidase activity
FBF33_RS02535	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FBF33_RS02540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FBF33_RS02550	COG0556	nucleotide-excision repair
FBF33_RS02565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FBF33_RS02575	COG3958	Transketolase
FBF33_RS02580	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FBF33_RS02595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FBF33_RS02620	COG0584	glycerophosphoryl diester phosphodiesterase
FBF33_RS02625	COG0492	ferredoxin-NADP+ reductase activity
FBF33_RS02635	COG1132	(ABC) transporter
FBF33_RS02650	COG0072	phenylalanine-tRNA ligase activity
FBF33_RS02650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FBF33_RS02655	COG1051	belongs to the nudix hydrolase family
FBF33_RS02670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FBF33_RS02705	COG1328	CTP reductase activity
FBF33_RS02705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FBF33_RS02745	COG0336	Belongs to the RNA methyltransferase TrmD family
FBF33_RS02755	COG1837	Belongs to the UPF0109 family
FBF33_RS02770	COG0571	ribonuclease III activity
FBF33_RS02780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FBF33_RS02785	COG0495	leucyl-tRNA aminoacylation
FBF33_RS02795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FBF33_RS02810	COG0765	amino acid transport
FBF33_RS02815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FBF33_RS02930	COG1131	(ABC) transporter
FBF33_RS02950	COG0330	HflC and HflK could
FBF33_RS02970	COG0366	Alpha amylase catalytic
FBF33_RS02995	COG0724	RNA recognition motif
FBF33_RS03005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FBF33_RS03050	COG1950	PFAM Membrane protein of
FBF33_RS03055	COG0006	proline dipeptidase activity
FBF33_RS03065	COG0322	excinuclease ABC activity
FBF33_RS03070	COG3118	belongs to the thioredoxin family
FBF33_RS03080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FBF33_RS03090	COG1132	(ABC) transporter
FBF33_RS03095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FBF33_RS03100	COG0586	Pfam SNARE associated Golgi protein
FBF33_RS03105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FBF33_RS03115	COG2925	Exonuclease
FBF33_RS03130	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FBF33_RS03135	COG3942	CHAP domain
FBF33_RS03135	COG1388	LysM domain
FBF33_RS03145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FBF33_RS03155	COG0849	cell division
FBF33_RS03165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FBF33_RS03175	COG0482	sulfurtransferase activity
FBF33_RS03200	COG0084	hydrolase, TatD family'
FBF33_RS03205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FBF33_RS03240	COG0149	triose-phosphate isomerase activity
FBF33_RS03245	COG0126	phosphoglycerate kinase activity
FBF33_RS03250	COG0469	pyruvate kinase activity
FBF33_RS03260	COG1136	(ABC) transporter
FBF33_RS03310	COG0424	maF-like protein
FBF33_RS03355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FBF33_RS03370	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FBF33_RS03370	COG0456	acetyltransferase
FBF33_RS03375	COG5002	protein histidine kinase activity
FBF33_RS03380	COG0745	RESPONSE REGULATOR receiver
FBF33_RS03390	COG3676	manually curated
FBF33_RS03410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FBF33_RS03435	COG5002	protein histidine kinase activity
FBF33_RS03445	COG0784	Response regulator, receiver
FBF33_RS03445	COG2205	protein histidine kinase activity
FBF33_RS03450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FBF33_RS03470	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FBF33_RS03495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FBF33_RS03500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FBF33_RS03545	COG0542	response to heat
FBF33_RS03555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FBF33_RS03585	COG0588	phosphoglycerate mutase activity
FBF33_RS03590	COG0148	phosphopyruvate hydratase activity
FBF33_RS03600	COG0494	nUDIX hydrolase
FBF33_RS03610	COG1214	PFAM Peptidase M22, glycoprotease
FBF33_RS03615	COG0802	atpase or kinase
FBF33_RS03620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FBF33_RS03655	COG2137	regulation of response to DNA damage stimulus
FBF33_RS03675	COG4968	Prepilin-type N-terminal cleavage methylation domain
FBF33_RS03685	COG2255	four-way junction helicase activity
FBF33_RS03690	COG0632	four-way junction helicase activity
FBF33_RS03695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FBF33_RS03695	COG4499	WXG100 protein secretion system (Wss), protein YukC
FBF33_RS03700	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FBF33_RS03715	COG0217	transcriptional regulatory protein
FBF33_RS03740	COG0189	ligase activity
FBF33_RS03770	COG1253	flavin adenine dinucleotide binding
FBF33_RS03780	COG0443	Heat shock 70 kDa protein
FBF33_RS03785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FBF33_RS03795	COG0494	nUDIX hydrolase
FBF33_RS03805	COG1420	regulation of RNA biosynthetic process
FBF33_RS03810	COG0194	GDP metabolic process
FBF33_RS03825	COG0481	GTPase activity
FBF33_RS03845	COG0481	GTPase activity
FBF33_RS03875	COG0481	GTPase activity
FBF33_RS03885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FBF33_RS03890	COG0037	tRNA processing
FBF33_RS03895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FBF33_RS03925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FBF33_RS03930	COG0464	growth
FBF33_RS04000	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FBF33_RS04010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FBF33_RS04015	COG0668	transmembrane transport
FBF33_RS04030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FBF33_RS04040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FBF33_RS04040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FBF33_RS04045	COG0477	Major facilitator Superfamily
FBF33_RS04070	COG1695	Transcriptional regulator
FBF33_RS04075	COG1136	(ABC) transporter
FBF33_RS04080	COG1136	(ABC) transporter
FBF33_RS04080	COG0577	efflux transmembrane transporter activity
FBF33_RS04095	COG1872	DUF167
FBF33_RS04115	COG2003	Belongs to the UPF0758 family
FBF33_RS04120	COG3850	Histidine kinase
FBF33_RS04120	COG5002	protein histidine kinase activity
FBF33_RS04130	COG1619	proteins homologs of microcin C7 resistance protein MccF
FBF33_RS04170	COG0701	Predicted permease
FBF33_RS04175	COG0494	nUDIX hydrolase
FBF33_RS04220	COG0438	transferase activity, transferring glycosyl groups
FBF33_RS04245	COG1215	transferase activity, transferring glycosyl groups
FBF33_RS04265	COG0463	Glycosyl transferase, family 2
FBF33_RS04315	COG0438	transferase activity, transferring glycosyl groups
FBF33_RS04325	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FBF33_RS04330	COG0045	succinate-CoA ligase (ADP-forming) activity
FBF33_RS04335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FBF33_RS04340	COG0463	Glycosyl transferase, family 2
FBF33_RS04360	COG1847	R3H domain protein
FBF33_RS04365	COG0706	membrane insertase activity
FBF33_RS04375	COG0230	Belongs to the bacterial ribosomal protein bL34 family