locus-tag	class	description
DDE25_RS00005	COG0321	lipoyl(octanoyl) transferase activity
DDE25_RS00010	COG0706	membrane insertase activity
DDE25_RS00015	COG0525	valine-tRNA ligase activity
DDE25_RS00020	COG0592	DNA-directed DNA polymerase activity
DDE25_RS00025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDE25_RS00025	COG0072	phenylalanine-tRNA ligase activity
DDE25_RS00030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DDE25_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DDE25_RS00040	COG0539	negative regulation of cytoplasmic translation
DDE25_RS00055	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DDE25_RS00060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DDE25_RS00075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DDE25_RS00085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DDE25_RS00095	COG0481	GTPase activity
DDE25_RS00100	COG0470	DNA polymerase III
DDE25_RS00105	COG0826	peptidase U32
DDE25_RS00115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DDE25_RS00130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DDE25_RS00140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DDE25_RS00145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DDE25_RS00150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDE25_RS00150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DDE25_RS00160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DDE25_RS00185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DDE25_RS00190	COG0356	it plays a direct role in the translocation of protons across the membrane
DDE25_RS00195	COG0527	aspartate kinase activity
DDE25_RS00195	COG0460	homoserine dehydrogenase
DDE25_RS00200	COG2095	MarC family integral membrane protein
DDE25_RS00205	COG0473	3-isopropylmalate dehydrogenase activity
DDE25_RS00215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DDE25_RS00220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DDE25_RS00230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DDE25_RS00240	COG3959	Transketolase, thiamine diphosphate binding domain
DDE25_RS00245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DDE25_RS00255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DDE25_RS00280	COG0564	pseudouridine synthase activity
DDE25_RS00285	COG0101	tRNA pseudouridine synthase activity
DDE25_RS00300	COG0222	ribosome binding
DDE25_RS00305	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DDE25_RS00310	COG0081	regulation of translation
DDE25_RS00355	COG0617	tRNA 3'-terminal CCA addition
DDE25_RS00360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DDE25_RS00365	COG2171	N-acyltransferase activity
DDE25_RS00390	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DDE25_RS00400	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DDE25_RS00405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DDE25_RS00415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DDE25_RS00430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DDE25_RS00435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DDE25_RS00470	COG2166	iron-sulfur cluster assembly
DDE25_RS00485	COG0484	heat shock protein binding
DDE25_RS00490	COG1418	mRNA catabolic process
DDE25_RS00500	COG0305	Participates in initiation and elongation during chromosome replication
DDE25_RS00510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DDE25_RS00515	COG0857	belongs to the CobB CobQ family
DDE25_RS00515	COG0280	phosphate acetyltransferase
DDE25_RS00520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DDE25_RS00540	COG0137	argininosuccinate synthase activity
DDE25_RS00565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DDE25_RS00570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DDE25_RS00590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DDE25_RS00595	COG0037	tRNA processing
DDE25_RS00605	COG0133	tryptophan synthase activity
DDE25_RS00610	COG0134	indole-3-glycerol-phosphate synthase activity
DDE25_RS00615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DDE25_RS00620	COG0512	Glutamine amidotransferase of anthranilate synthase
DDE25_RS00620	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DDE25_RS00625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DDE25_RS00630	COG0442	prolyl-tRNA aminoacylation
DDE25_RS00640	COG0019	diaminopimelate decarboxylase activity
DDE25_RS00655	COG0326	Molecular chaperone. Has ATPase activity
DDE25_RS00660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DDE25_RS00670	COG0335	large ribosomal subunit rRNA binding
DDE25_RS00675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DDE25_RS00680	COG0423	glycine-tRNA ligase activity
DDE25_RS00685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DDE25_RS00690	COG0083	homoserine kinase activity
DDE25_RS00695	COG0527	aspartate kinase activity
DDE25_RS00695	COG0460	homoserine dehydrogenase
DDE25_RS00735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DDE25_RS00760	COG0233	cytoplasmic translational termination
DDE25_RS00765	COG0017	Asparaginyl-tRNA synthetase
DDE25_RS00795	COG0360	Binds together with S18 to 16S ribosomal RNA
DDE25_RS00825	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DDE25_RS00830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DDE25_RS00835	COG0681	Belongs to the peptidase S26 family
DDE25_RS00845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DDE25_RS00855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DDE25_RS00875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DDE25_RS00880	COG0567	Dehydrogenase, E1 component
DDE25_RS00885	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDE25_RS00890	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DDE25_RS00895	COG0488	(ABC) transporter
DDE25_RS00900	COG2151	metal-sulfur cluster biosynthetic enzyme
DDE25_RS00920	COG0719	Fe-S assembly protein
DDE25_RS00925	COG0396	ATPase activity
DDE25_RS00930	COG0719	Fe-S assembly protein
DDE25_RS00935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DDE25_RS00940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DDE25_RS00940	COG0195	Participates in both transcription termination and antitermination
DDE25_RS00945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DDE25_RS00950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DDE25_RS00955	COG0077	Prephenate dehydratase
DDE25_RS00955	COG1605	Chorismate mutase
DDE25_RS00960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DDE25_RS00995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DDE25_RS01010	COG0436	Aminotransferase
DDE25_RS01015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DDE25_RS01020	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDE25_RS01020	COG0022	dehydrogenase e1 component
DDE25_RS01025	COG0191	fructose-bisphosphate aldolase activity
DDE25_RS01035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DDE25_RS01050	COG0254	rRNA binding
DDE25_RS01070	COG0051	transcription antitermination factor activity, RNA binding
DDE25_RS01080	COG0088	Forms part of the polypeptide exit tunnel
DDE25_RS01115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DDE25_RS01125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DDE25_RS01135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DDE25_RS01160	COG1841	ribosomal large subunit assembly
DDE25_RS01165	COG0200	Binds to the 23S rRNA
DDE25_RS01170	COG0201	protein transport
DDE25_RS01175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DDE25_RS01200	COG0202	RNA polymerase activity
DDE25_RS01205	COG0203	ribosomal protein L17
DDE25_RS01210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DDE25_RS01225	COG1012	belongs to the aldehyde dehydrogenase family
DDE25_RS01230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DDE25_RS01235	COG0165	Argininosuccinate lyase
DDE25_RS01240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DDE25_RS01255	COG0508	dehydrogenase complex catalyzes the overall conversion of
DDE25_RS01260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DDE25_RS01275	COG0492	ferredoxin-NADP+ reductase activity
DDE25_RS01280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DDE25_RS01290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DDE25_RS01295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DDE25_RS01305	COG0028	Belongs to the TPP enzyme family