locus-tag	class	description
HUE88_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUE88_RS00010	COG0592	DNA-directed DNA polymerase activity
HUE88_RS00015	COG0187	DNA topoisomerase II activity
HUE88_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HUE88_RS00030	COG0617	tRNA 3'-terminal CCA addition
HUE88_RS00035	COG1217	gtp-binding protein TYPA
HUE88_RS00045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUE88_RS00050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUE88_RS00080	COG0242	peptide deformylase activity
HUE88_RS00085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUE88_RS00100	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HUE88_RS00120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUE88_RS00125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUE88_RS00130	COG0358	DNA primase activity
HUE88_RS00140	COG0513	Belongs to the DEAD box helicase family
HUE88_RS00145	COG0482	sulfurtransferase activity
HUE88_RS00165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HUE88_RS00175	COG1749	Flagellar hook protein flgE
HUE88_RS00180	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HUE88_RS00185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUE88_RS00190	COG1238	metal cluster binding
HUE88_RS00200	COG1053	succinate dehydrogenase
HUE88_RS00210	COG1666	GTP binding
HUE88_RS00245	COG1032	radical SAM domain protein
HUE88_RS00250	COG2814	Major facilitator Superfamily
HUE88_RS00255	COG0668	transmembrane transport
HUE88_RS00285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUE88_RS00295	COG3746	phosphate-selective porin O and P
HUE88_RS00310	COG1592	Rubrerythrin
HUE88_RS00320	COG0071	Belongs to the small heat shock protein (HSP20) family
HUE88_RS00325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE88_RS00325	COG0574	Belongs to the PEP-utilizing enzyme family
HUE88_RS00345	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUE88_RS00365	COG4251	negative regulation of phosphorylation
HUE88_RS00365	COG5001	Diguanylate cyclase
HUE88_RS00365	COG2203	Gaf domain
HUE88_RS00365	COG3706	GGDEF domain
HUE88_RS00370	COG1492	cobalamin metabolic process
HUE88_RS00395	COG1944	ATP diphosphatase activity
HUE88_RS00400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUE88_RS00405	COG1120	ATPase activity
HUE88_RS00435	COG4206	TonB-dependent receptor
HUE88_RS00455	COG0575	Belongs to the CDS family
HUE88_RS00460	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUE88_RS00465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUE88_RS00470	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HUE88_RS00485	COG0642	Histidine kinase
HUE88_RS00490	COG0745	RESPONSE REGULATOR receiver
HUE88_RS00510	COG0840	transmembrane signaling receptor activity
HUE88_RS00525	COG2259	Doxx family
HUE88_RS00545	COG1322	Protein conserved in bacteria
HUE88_RS00555	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE88_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE88_RS00585	COG4895	conserved protein (DUF2196)
HUE88_RS00590	COG0513	Belongs to the DEAD box helicase family
HUE88_RS00595	COG1451	nucleotide metabolic process
HUE88_RS00600	COG0488	(ABC) transporter
HUE88_RS00610	COG2353	YceI-like domain
HUE88_RS00625	COG1309	transcriptional regulator
HUE88_RS00630	COG2183	response to ionizing radiation
HUE88_RS00635	COG3706	GGDEF domain
HUE88_RS00645	COG0745	RESPONSE REGULATOR receiver
HUE88_RS00650	COG0642	Histidine kinase
HUE88_RS00660	COG2863	cytochrome
HUE88_RS00680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUE88_RS00690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUE88_RS00690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUE88_RS00705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUE88_RS00720	COG0367	asparagine synthase
HUE88_RS00730	COG2239	Acts as a magnesium transporter
HUE88_RS00735	COG1253	flavin adenine dinucleotide binding
HUE88_RS00740	COG0840	transmembrane signaling receptor activity
HUE88_RS00765	COG1301	dicarboxylic acid transport
HUE88_RS00770	COG2199	diguanylate cyclase activity
HUE88_RS00770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUE88_RS00775	COG0745	RESPONSE REGULATOR receiver
HUE88_RS00800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUE88_RS00800	COG0426	domain, Protein
HUE88_RS00815	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HUE88_RS00820	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUE88_RS00830	COG0840	transmembrane signaling receptor activity
HUE88_RS00835	COG3347	Dehydrogenase
HUE88_RS00835	COG1028	Short-chain dehydrogenase reductase Sdr
HUE88_RS00845	COG1115	amino acid carrier protein
HUE88_RS00880	COG4584	PFAM Integrase catalytic
HUE88_RS00885	COG1484	DNA-dependent DNA replication
HUE88_RS00900	COG2204	response regulator
HUE88_RS00905	COG3920	Histidine kinase
HUE88_RS00925	COG3328	transposase activity
HUE88_RS00940	COG4974	Belongs to the 'phage' integrase family
HUE88_RS00945	COG0582	viral genome integration into host DNA
HUE88_RS01115	COG3885	ferrous iron binding
HUE88_RS01115	COG2078	PFAM AMMECR1 domain protein
HUE88_RS01120	COG1355	regulation of microtubule-based process
HUE88_RS01135	COG1252	NADH dehydrogenase
HUE88_RS01140	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUE88_RS01160	COG0166	Belongs to the GPI family
HUE88_RS01165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUE88_RS01185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUE88_RS01200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUE88_RS01210	COG1222	aaa ATPase
HUE88_RS01215	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE88_RS01220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE88_RS01225	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE88_RS01230	COG0649	NAD binding
HUE88_RS01250	COG1034	ATP synthesis coupled electron transport
HUE88_RS01255	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUE88_RS01260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE88_RS01265	COG0839	Belongs to the complex I subunit 6 family
HUE88_RS01270	COG0713	ATP synthesis coupled electron transport
HUE88_RS01275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUE88_RS01285	COG1007	ATP synthesis coupled electron transport
HUE88_RS01295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUE88_RS01320	COG0772	Belongs to the SEDS family
HUE88_RS01325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUE88_RS01330	COG0586	Pfam SNARE associated Golgi protein
HUE88_RS01345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUE88_RS01355	COG0052	Belongs to the universal ribosomal protein uS2 family
HUE88_RS01360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUE88_RS01365	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE88_RS01370	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE88_RS01375	COG0649	NAD binding
HUE88_RS01375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE88_RS01380	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HUE88_RS01390	COG1034	ATP synthesis coupled electron transport
HUE88_RS01395	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUE88_RS01400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE88_RS01410	COG0713	ATP synthesis coupled electron transport
HUE88_RS01415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUE88_RS01420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE88_RS01425	COG1007	ATP synthesis coupled electron transport
HUE88_RS01440	COG1136	(ABC) transporter
HUE88_RS01445	COG1684	flagellar biosynthetic protein fliR
HUE88_RS01455	COG0194	GDP metabolic process
HUE88_RS01460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUE88_RS01465	COG0018	arginyl-trna synthetase
HUE88_RS01485	COG1757	Na H antiporter
HUE88_RS01490	COG2176	DNA-directed DNA polymerase activity
HUE88_RS01510	COG4948	Mandelate Racemase Muconate Lactonizing
HUE88_RS01515	COG0745	RESPONSE REGULATOR receiver
HUE88_RS01520	COG3437	response regulator, receiver
HUE88_RS01530	COG3706	GGDEF domain
HUE88_RS01540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUE88_RS01555	COG2255	four-way junction helicase activity
HUE88_RS01560	COG3864	Putative metallopeptidase domain
HUE88_RS01565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE88_RS01575	COG0450	alkyl hydroperoxide reductase
HUE88_RS01585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUE88_RS01595	COG0105	UTP biosynthetic process
HUE88_RS01605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUE88_RS01610	COG0416	fatty acid biosynthetic process
HUE88_RS01615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUE88_RS01635	COG0513	Belongs to the DEAD box helicase family
HUE88_RS01645	COG0668	transmembrane transport
HUE88_RS01655	COG1183	phosphatidylcholine synthase activity
HUE88_RS01680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HUE88_RS01685	COG0745	RESPONSE REGULATOR receiver
HUE88_RS01690	COG0642	Histidine kinase
HUE88_RS01695	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HUE88_RS01700	COG0840	transmembrane signaling receptor activity
HUE88_RS01710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUE88_RS01715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUE88_RS01720	COG0126	phosphoglycerate kinase activity
HUE88_RS01725	COG0149	triose-phosphate isomerase activity
HUE88_RS01730	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUE88_RS01755	COG0195	Participates in both transcription termination and antitermination
HUE88_RS01765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUE88_RS01770	COG2121	Domain of unknown function (DUF374)
HUE88_RS01800	COG0037	tRNA processing
HUE88_RS01805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUE88_RS01810	COG2081	HI0933 family
HUE88_RS01815	COG0475	glutathione-regulated potassium exporter activity
HUE88_RS01815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUE88_RS01825	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HUE88_RS01830	COG3005	denitrification pathway
HUE88_RS01860	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HUE88_RS01870	COG0556	nucleotide-excision repair
HUE88_RS01875	COG1401	restriction endodeoxyribonuclease activity
HUE88_RS01980	COG0556	nucleotide-excision repair
HUE88_RS01990	COG0582	viral genome integration into host DNA
HUE88_RS01995	COG1484	DNA-dependent DNA replication
HUE88_RS02000	COG4584	PFAM Integrase catalytic
HUE88_RS02110	COG0415	Belongs to the DNA photolyase family
HUE88_RS02120	COG0471	metal ion transport
HUE88_RS02130	COG0840	transmembrane signaling receptor activity
HUE88_RS02140	COG3420	alginic acid biosynthetic process
HUE88_RS02155	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUE88_RS02180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUE88_RS02185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUE88_RS02190	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUE88_RS02200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUE88_RS02205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUE88_RS02210	COG0825	malonyl-CoA metabolic process
HUE88_RS02215	COG2176	DNA-directed DNA polymerase activity
HUE88_RS02220	COG0135	phosphoribosylanthranilate isomerase activity
HUE88_RS02225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUE88_RS02240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUE88_RS02245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUE88_RS02250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUE88_RS02255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUE88_RS02265	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUE88_RS02270	COG1862	Preprotein translocase
HUE88_RS02275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUE88_RS02280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUE88_RS02295	COG0557	exoribonuclease II activity
HUE88_RS02315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUE88_RS02325	COG0495	leucyl-tRNA aminoacylation
HUE88_RS02340	COG0285	dihydrofolate synthase activity
HUE88_RS02345	COG0739	heme binding
HUE88_RS02355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUE88_RS02360	COG1692	metallophosphoesterase
HUE88_RS02370	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HUE88_RS02375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUE88_RS02380	COG0481	GTPase activity
HUE88_RS02400	COG0745	RESPONSE REGULATOR receiver
HUE88_RS02405	COG2205	protein histidine kinase activity
HUE88_RS02410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUE88_RS02430	COG2201	protein-glutamate methylesterase activity
HUE88_RS02435	COG0643	Histidine kinase
HUE88_RS02435	COG2198	Histidine kinase
HUE88_RS02445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUE88_RS02450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUE88_RS02455	COG0840	transmembrane signaling receptor activity
HUE88_RS02470	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HUE88_RS02495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUE88_RS02500	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUE88_RS02510	COG0784	Response regulator, receiver
HUE88_RS02510	COG0835	chemotaxis
HUE88_RS02515	COG2198	Histidine kinase
HUE88_RS02515	COG0784	Response regulator, receiver
HUE88_RS02515	COG0643	Histidine kinase
HUE88_RS02520	COG0835	chemotaxis
HUE88_RS02525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUE88_RS02530	COG1127	ABC transporter
HUE88_RS02545	COG0006	proline dipeptidase activity
HUE88_RS02565	COG0840	transmembrane signaling receptor activity
HUE88_RS02585	COG0348	domain, Protein
HUE88_RS02590	COG0437	4 iron, 4 sulfur cluster binding
HUE88_RS02595	COG0243	molybdopterin cofactor binding
HUE88_RS02610	COG3706	GGDEF domain
HUE88_RS02610	COG5001	Diguanylate cyclase
HUE88_RS02610	COG4251	negative regulation of phosphorylation
HUE88_RS02610	COG2203	Gaf domain
HUE88_RS02630	COG0488	(ABC) transporter
HUE88_RS02635	COG0579	oxidoreductase
HUE88_RS02680	COG3012	SEC-C Motif Domain Protein
HUE88_RS02685	COG0280	phosphate acetyltransferase
HUE88_RS02685	COG0857	belongs to the CobB CobQ family
HUE88_RS02690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUE88_RS02695	COG1278	Cold shock
HUE88_RS02755	COG3328	transposase activity
HUE88_RS02825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE88_RS02840	COG3290	protein histidine kinase activity
HUE88_RS02840	COG0840	transmembrane signaling receptor activity
HUE88_RS02850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUE88_RS02855	COG0668	transmembrane transport
HUE88_RS02885	COG2046	Belongs to the sulfate adenylyltransferase family
HUE88_RS02890	COG0745	RESPONSE REGULATOR receiver
HUE88_RS02895	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUE88_RS02895	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUE88_RS02900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUE88_RS02905	COG0489	protein tyrosine kinase activity
HUE88_RS02915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUE88_RS02920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUE88_RS02930	COG1070	Carbohydrate kinase
HUE88_RS02935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUE88_RS02940	COG2860	membrane
HUE88_RS02945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUE88_RS02965	COG1793	dna ligase
HUE88_RS02970	COG0166	Belongs to the GPI family
HUE88_RS02990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUE88_RS02995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HUE88_RS03030	COG0673	inositol 2-dehydrogenase activity
HUE88_RS03040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUE88_RS03090	COG1086	Polysaccharide biosynthesis protein
HUE88_RS03120	COG2026	Addiction module toxin, RelE StbE family
HUE88_RS03125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUE88_RS03135	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
HUE88_RS03150	COG1086	Polysaccharide biosynthesis protein
HUE88_RS03165	COG1555	photosystem II stabilization
HUE88_RS03175	COG1396	sequence-specific DNA binding
HUE88_RS03185	COG3328	transposase activity
HUE88_RS03190	COG0754	glutathionylspermidine amidase activity
HUE88_RS03210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUE88_RS03220	COG1077	Cell shape determining protein MreB Mrl
HUE88_RS03225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUE88_RS03230	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUE88_RS03235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUE88_RS03240	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUE88_RS03255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUE88_RS03260	COG0642	Histidine kinase
HUE88_RS03265	COG0745	RESPONSE REGULATOR receiver
HUE88_RS03280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUE88_RS03290	COG2176	DNA-directed DNA polymerase activity
HUE88_RS03295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUE88_RS03300	COG0284	orotidine-5'-phosphate decarboxylase activity
HUE88_RS03320	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HUE88_RS03450	COG2274	protein secretion by the type I secretion system
HUE88_RS03465	COG0745	RESPONSE REGULATOR receiver
HUE88_RS03470	COG4191	Histidine kinase
HUE88_RS03475	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUE88_RS03480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE88_RS03495	COG0251	oxidation-reduction process
HUE88_RS03500	COG1309	transcriptional regulator
HUE88_RS03515	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HUE88_RS03520	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HUE88_RS03525	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HUE88_RS03530	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HUE88_RS03540	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HUE88_RS03560	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUE88_RS03565	COG0298	carbon dioxide binding
HUE88_RS03570	COG0409	Hydrogenase expression formation protein
HUE88_RS03575	COG3177	Filamentation induced by cAMP protein fic
HUE88_RS03585	COG1401	restriction endodeoxyribonuclease activity
HUE88_RS03590	COG4804	nuclease activity
HUE88_RS03595	COG4628	conserved protein (DUF2132)
HUE88_RS03600	COG0309	Hydrogenase expression formation protein (HypE)
HUE88_RS03605	COG0375	protein maturation
HUE88_RS03610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUE88_RS03615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUE88_RS03620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUE88_RS03625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUE88_RS03630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUE88_RS03635	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HUE88_RS03635	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HUE88_RS03640	COG1192	Involved in chromosome partitioning
HUE88_RS03645	COG1475	DNA binding
HUE88_RS03660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUE88_RS03665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUE88_RS03670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUE88_RS03675	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUE88_RS03680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUE88_RS03685	COG0811	peptide transport
HUE88_RS03690	COG0848	biopolymer transport protein
HUE88_RS03700	COG0823	Involved in the tonB-independent uptake of proteins
HUE88_RS03705	COG2885	chlorophyll binding
HUE88_RS03715	COG1047	Peptidyl-prolyl cis-trans
HUE88_RS03720	COG2204	response regulator
HUE88_RS03725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUE88_RS03730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUE88_RS03730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUE88_RS03735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUE88_RS03740	COG0037	tRNA processing
HUE88_RS03750	COG0217	transcriptional regulatory protein
HUE88_RS03755	COG1739	Uncharacterized protein family UPF0029
HUE88_RS03765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUE88_RS03825	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HUE88_RS03830	COG0359	binds to the 23S rRNA
HUE88_RS03840	COG0137	argininosuccinate synthase activity
HUE88_RS03885	COG2165	general secretion pathway protein
HUE88_RS03895	COG1459	type II secretion system
HUE88_RS03930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUE88_RS03945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUE88_RS03965	COG0585	pseudouridine synthase activity
HUE88_RS03970	COG0356	it plays a direct role in the translocation of protons across the membrane
HUE88_RS03980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUE88_RS03985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUE88_RS03995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUE88_RS04000	COG2815	serine threonine protein kinase
HUE88_RS04000	COG0515	serine threonine protein kinase
HUE88_RS04005	COG0471	metal ion transport
HUE88_RS04025	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUE88_RS04030	COG1136	(ABC) transporter
HUE88_RS04035	COG0501	Belongs to the peptidase M48B family
HUE88_RS04040	COG2890	protein-(glutamine-N5) methyltransferase activity
HUE88_RS04065	COG0577	efflux transmembrane transporter activity
HUE88_RS04065	COG1136	(ABC) transporter
HUE88_RS04080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUE88_RS04085	COG0849	cell division
HUE88_RS04100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUE88_RS04110	COG0484	heat shock protein binding
HUE88_RS04115	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HUE88_RS04120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUE88_RS04125	COG2853	Lipoprotein
HUE88_RS04140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUE88_RS04145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUE88_RS04160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUE88_RS04165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUE88_RS04180	COG3706	GGDEF domain
HUE88_RS04185	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUE88_RS04190	COG0488	(ABC) transporter
HUE88_RS04195	COG4191	Histidine kinase
HUE88_RS04210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUE88_RS04215	COG0686	Belongs to the AlaDH PNT family
HUE88_RS04220	COG3287	FIST C domain
HUE88_RS04220	COG2200	EAL domain
HUE88_RS04220	COG2199	diguanylate cyclase activity
HUE88_RS04250	COG5002	protein histidine kinase activity
HUE88_RS04255	COG1971	Probably functions as a manganese efflux pump
HUE88_RS04295	COG3259	Nickel-dependent hydrogenase
HUE88_RS04310	COG2111	Na H antiporter
HUE88_RS04310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUE88_RS04315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUE88_RS04320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUE88_RS04330	COG1283	sodium-dependent phosphate transmembrane transporter activity
HUE88_RS04340	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HUE88_RS04340	COG3261	NADH dehydrogenase
HUE88_RS04350	COG0667	Aldo Keto reductase
HUE88_RS04360	COG0326	Molecular chaperone. Has ATPase activity
HUE88_RS04380	COG2814	Major facilitator Superfamily
HUE88_RS04385	COG3630	sodium ion export across plasma membrane
HUE88_RS04390	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUE88_RS04400	COG0784	Response regulator, receiver
HUE88_RS04400	COG0835	chemotaxis
HUE88_RS04410	COG0243	molybdopterin cofactor binding
HUE88_RS04430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUE88_RS04450	COG1393	Belongs to the ArsC family
HUE88_RS04455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUE88_RS04500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUE88_RS04500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUE88_RS04515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUE88_RS04520	COG1592	Rubrerythrin
HUE88_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
HUE88_RS04555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE88_RS04570	COG0612	Peptidase, M16
HUE88_RS04575	COG0167	dihydroorotate dehydrogenase activity
HUE88_RS04585	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUE88_RS04595	COG0277	FAD linked oxidase domain protein
HUE88_RS04605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUE88_RS04620	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUE88_RS04635	COG0215	cysteine-tRNA ligase activity
HUE88_RS04655	COG0728	peptidoglycan biosynthetic process
HUE88_RS04665	COG0632	four-way junction helicase activity
HUE88_RS04670	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUE88_RS04680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUE88_RS04710	COG2326	polyphosphate kinase activity
HUE88_RS04715	COG3039	Transposase
HUE88_RS04735	COG3264	Mechanosensitive ion channel
HUE88_RS04735	COG1196	nuclear chromosome segregation
HUE88_RS04745	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HUE88_RS04755	COG0439	Biotin carboxylase
HUE88_RS04935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUE88_RS05045	COG1730	sister chromatid segregation
HUE88_RS05080	COG0500	methyltransferase
HUE88_RS05085	COG2165	general secretion pathway protein
HUE88_RS05090	COG1459	type II secretion system
HUE88_RS05095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUE88_RS05135	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUE88_RS05145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUE88_RS05150	COG1053	succinate dehydrogenase
HUE88_RS05160	COG0708	Exodeoxyribonuclease III
HUE88_RS05165	COG2048	Heterodisulfide reductase, subunit B
HUE88_RS05195	COG0585	pseudouridine synthase activity
HUE88_RS05200	COG0688	phosphatidylethanolamine metabolic process
HUE88_RS05210	COG0012	GTP binding
HUE88_RS05230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUE88_RS05240	COG0133	tryptophan synthase activity
HUE88_RS05245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUE88_RS05255	COG0698	ribose 5-phosphate isomerase
HUE88_RS05260	COG1994	Peptidase M50
HUE88_RS05265	COG0681	Belongs to the peptidase S26 family
HUE88_RS05270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUE88_RS05290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUE88_RS05310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUE88_RS05315	COG4786	Flagellar basal body rod
HUE88_RS05320	COG4786	Flagellar basal body rod
HUE88_RS05325	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HUE88_RS05335	COG0069	glutamate synthase activity
HUE88_RS05335	COG0070	glutamate synthase
HUE88_RS05335	COG0067	glutamate synthase
HUE88_RS05340	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUE88_RS05340	COG0493	'glutamate synthase
HUE88_RS05345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUE88_RS05350	COG0352	thiamine-phosphate diphosphorylase activity
HUE88_RS05355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HUE88_RS05370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUE88_RS05385	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE88_RS05385	COG1776	CheC inhibitor of MCP methylation
HUE88_RS05395	COG0730	response to heat
HUE88_RS05400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUE88_RS05420	COG1227	inorganic diphosphatase activity
HUE88_RS05435	COG0318	PFAM AMP-dependent synthetase and ligase
HUE88_RS05440	COG1032	radical SAM domain protein
HUE88_RS05445	COG2199	diguanylate cyclase activity
HUE88_RS05445	COG2200	EAL domain
HUE88_RS05445	COG3287	FIST C domain
HUE88_RS05450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUE88_RS05455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUE88_RS05460	COG0802	atpase or kinase
HUE88_RS05465	COG1137	ATPase activity
HUE88_RS05470	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HUE88_RS05480	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HUE88_RS05495	COG0716	FMN binding
HUE88_RS05500	COG0347	Belongs to the P(II) protein family
HUE88_RS05520	COG0633	Ferredoxin
HUE88_RS05525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HUE88_RS05570	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HUE88_RS05590	COG0426	domain, Protein
HUE88_RS05600	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HUE88_RS05610	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HUE88_RS05615	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HUE88_RS05650	COG0667	Aldo Keto reductase
HUE88_RS05655	COG1053	succinate dehydrogenase
HUE88_RS05680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUE88_RS05725	COG0651	ATP synthesis coupled electron transport
HUE88_RS05730	COG0651	ATP synthesis coupled electron transport
HUE88_RS05735	COG1007	ATP synthesis coupled electron transport
HUE88_RS05750	COG1320	monovalent cation:proton antiporter activity
HUE88_RS05760	COG0589	response to stress
HUE88_RS05810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUE88_RS05815	COG0535	radical SAM domain protein
HUE88_RS05815	COG1433	Dinitrogenase iron-molybdenum cofactor
HUE88_RS05825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUE88_RS05895	COG2354	Protein conserved in bacteria
HUE88_RS05965	COG1218	3'(2'),5'-bisphosphate nucleotidase
HUE88_RS05970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUE88_RS06025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE88_RS06060	COG3706	GGDEF domain
HUE88_RS06135	COG4974	Belongs to the 'phage' integrase family
HUE88_RS06145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUE88_RS06155	COG0028	Belongs to the TPP enzyme family
HUE88_RS06160	COG0440	acetolactate synthase activity
HUE88_RS06165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUE88_RS06180	COG1045	serine acetyltransferase
HUE88_RS06185	COG1166	arginine decarboxylase activity
HUE88_RS06190	COG0069	glutamate synthase activity
HUE88_RS06195	COG0124	histidyl-tRNA synthetase
HUE88_RS06210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUE88_RS06215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUE88_RS06220	COG0163	prenyltransferase activity
HUE88_RS06235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUE88_RS06240	COG1196	nuclear chromosome segregation
HUE88_RS06240	COG1674	ftsk spoiiie
HUE88_RS06250	COG1049	propionate catabolic process, 2-methylcitrate cycle
HUE88_RS06255	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HUE88_RS06260	COG0653	protein targeting
HUE88_RS06275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUE88_RS06285	COG0039	L-malate dehydrogenase activity
HUE88_RS06290	COG0114	fumarate hydratase activity
HUE88_RS06295	COG0045	succinate-CoA ligase (ADP-forming) activity
HUE88_RS06300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUE88_RS06310	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUE88_RS06310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUE88_RS06315	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUE88_RS06360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUE88_RS06370	COG0741	lytic transglycosylase activity
HUE88_RS06385	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HUE88_RS06395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUE88_RS06395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUE88_RS06410	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUE88_RS06425	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUE88_RS06435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUE88_RS06445	COG0768	penicillin binding
HUE88_RS06455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUE88_RS06470	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HUE88_RS06475	COG0131	Imidazoleglycerol-phosphate dehydratase
HUE88_RS06480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUE88_RS06490	COG0084	hydrolase, TatD family'
HUE88_RS06495	COG0497	DNA recombination
HUE88_RS06535	COG0493	'glutamate synthase
HUE88_RS06535	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUE88_RS06550	COG2020	methyltransferase activity
HUE88_RS06555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUE88_RS06560	COG2203	Gaf domain
HUE88_RS06560	COG3706	GGDEF domain
HUE88_RS06560	COG4251	negative regulation of phosphorylation
HUE88_RS06560	COG5001	Diguanylate cyclase
HUE88_RS06565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUE88_RS06570	COG0563	adenylate kinase activity
HUE88_RS06575	COG0563	adenylate kinase activity
HUE88_RS06585	COG0513	Belongs to the DEAD box helicase family
HUE88_RS06600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HUE88_RS06630	COG2171	N-acyltransferase activity
HUE88_RS06660	COG0788	formyltetrahydrofolate deformylase activity
HUE88_RS06675	COG0473	3-isopropylmalate dehydrogenase activity
HUE88_RS06680	COG0066	3-isopropylmalate dehydratase activity
HUE88_RS06685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE88_RS06690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUE88_RS06700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUE88_RS06710	COG0784	Response regulator, receiver
HUE88_RS06710	COG2205	protein histidine kinase activity
HUE88_RS06715	COG0784	Response regulator, receiver
HUE88_RS06715	COG5002	protein histidine kinase activity
HUE88_RS06715	COG2205	protein histidine kinase activity
HUE88_RS06720	COG2201	protein-glutamate methylesterase activity
HUE88_RS06725	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HUE88_RS06740	COG2198	Histidine kinase
HUE88_RS06740	COG0643	Histidine kinase
HUE88_RS06750	COG0840	transmembrane signaling receptor activity
HUE88_RS06760	COG0745	RESPONSE REGULATOR receiver
HUE88_RS06770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUE88_RS06775	COG1338	Plays a role in the flagellum-specific transport system
HUE88_RS06785	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUE88_RS06790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUE88_RS06805	COG1254	Belongs to the acylphosphatase family
HUE88_RS06815	COG1027	Aspartate ammonia-lyase
HUE88_RS06820	COG1252	NADH dehydrogenase
HUE88_RS06845	COG3021	interspecies interaction between organisms
HUE88_RS06865	COG0475	glutathione-regulated potassium exporter activity
HUE88_RS06870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUE88_RS06880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUE88_RS06895	COG0101	tRNA pseudouridine synthase activity
HUE88_RS06900	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUE88_RS06905	COG2267	carboxylic ester hydrolase activity
HUE88_RS06935	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUE88_RS06965	COG3287	FIST C domain
HUE88_RS06965	COG2200	EAL domain
HUE88_RS06965	COG2199	diguanylate cyclase activity
HUE88_RS06975	COG0750	zinc metalloprotease
HUE88_RS06980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUE88_RS06995	COG2081	HI0933 family
HUE88_RS07010	COG0352	thiamine-phosphate diphosphorylase activity
HUE88_RS07050	COG0824	Thioesterase
HUE88_RS07070	COG0582	viral genome integration into host DNA
HUE88_RS07170	COG3706	GGDEF domain
HUE88_RS07185	COG3706	GGDEF domain
HUE88_RS07195	COG4974	Belongs to the 'phage' integrase family
HUE88_RS07210	COG4974	Belongs to the 'phage' integrase family
HUE88_RS07330	COG2204	response regulator
HUE88_RS07335	COG3920	Histidine kinase
HUE88_RS07355	COG3328	transposase activity
HUE88_RS07365	COG4584	PFAM Integrase catalytic
HUE88_RS07370	COG1484	DNA-dependent DNA replication
HUE88_RS07385	COG0784	Response regulator, receiver
HUE88_RS07385	COG3437	response regulator, receiver
HUE88_RS07395	COG0784	Response regulator, receiver
HUE88_RS07395	COG2205	protein histidine kinase activity
HUE88_RS07430	COG3437	response regulator, receiver
HUE88_RS07430	COG0784	Response regulator, receiver
HUE88_RS07435	COG3706	GGDEF domain
HUE88_RS07440	COG3093	addiction module antidote protein HigA
HUE88_RS07450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE88_RS07455	COG0243	molybdopterin cofactor binding
HUE88_RS07460	COG0631	protein serine/threonine phosphatase activity
HUE88_RS07465	COG2223	nitrite transmembrane transporter activity
HUE88_RS07475	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUE88_RS07510	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE88_RS07520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE88_RS07550	COG3328	transposase activity
HUE88_RS07555	COG4771	TonB-dependent receptor
HUE88_RS07570	COG0745	RESPONSE REGULATOR receiver
HUE88_RS07630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUE88_RS07640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUE88_RS07640	COG1333	cytochrome c biogenesis protein
HUE88_RS07645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUE88_RS07660	COG0642	Histidine kinase
HUE88_RS07665	COG1362	aminopeptidase activity
HUE88_RS07670	COG0587	DNA-directed DNA polymerase activity
HUE88_RS07680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUE88_RS07685	COG0343	queuine tRNA-ribosyltransferase activity
HUE88_RS07690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUE88_RS07710	COG4232	protein-disulfide reductase activity
HUE88_RS07720	COG0642	Histidine kinase
HUE88_RS07725	COG0745	RESPONSE REGULATOR receiver
HUE88_RS07765	COG1643	Atp-dependent helicase
HUE88_RS07790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HUE88_RS07805	COG1331	Highly conserved protein containing a thioredoxin domain
HUE88_RS07820	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUE88_RS07825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HUE88_RS07830	COG0840	transmembrane signaling receptor activity
HUE88_RS07845	COG0778	Nitroreductase
HUE88_RS07855	COG1408	metallophosphoesterase
HUE88_RS07870	COG0390	transport system, permease component
HUE88_RS07880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUE88_RS07885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUE88_RS07890	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUE88_RS07905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUE88_RS07915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUE88_RS07920	COG2954	triphosphatase activity
HUE88_RS07935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE88_RS07945	COG0539	negative regulation of cytoplasmic translation
HUE88_RS07945	COG1185	polyribonucleotide nucleotidyltransferase activity
HUE88_RS07950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUE88_RS07955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUE88_RS07960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUE88_RS07960	COG0072	phenylalanine-tRNA ligase activity
HUE88_RS07965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUE88_RS07970	COG0537	adenosine 5'-monophosphoramidase activity
HUE88_RS07985	COG0165	Argininosuccinate lyase
HUE88_RS07995	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUE88_RS08000	COG0181	hydroxymethylbilane synthase activity
HUE88_RS08010	COG3030	protein affecting phage T7 exclusion by the F plasmid
HUE88_RS08015	COG0442	prolyl-tRNA aminoacylation
HUE88_RS08020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUE88_RS08045	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUE88_RS08050	COG1663	tetraacyldisaccharide 4'-kinase activity
HUE88_RS08055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUE88_RS08060	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUE88_RS08075	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HUE88_RS08075	COG2050	protein possibly involved in aromatic compounds catabolism
HUE88_RS08080	COG0500	methyltransferase
HUE88_RS08095	COG1418	mRNA catabolic process
HUE88_RS08105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUE88_RS08110	COG0552	protein localization to endoplasmic reticulum
HUE88_RS08120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUE88_RS08130	COG1580	Controls the rotational direction of flagella during chemotaxis
HUE88_RS08135	COG0736	holo-[acyl-carrier-protein] synthase activity
HUE88_RS08155	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HUE88_RS08160	COG3842	ATPase activity
HUE88_RS08165	COG0725	ABC transporter, periplasmic molybdate-binding protein
HUE88_RS08170	COG0303	'Molybdopterin
HUE88_RS08190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUE88_RS08200	COG0437	4 iron, 4 sulfur cluster binding
HUE88_RS08230	COG3852	Histidine kinase
HUE88_RS08235	COG4565	transcriptional regulatory protein
HUE88_RS08240	COG0425	Belongs to the sulfur carrier protein TusA family
HUE88_RS08245	COG2391	methyltransferase activity
HUE88_RS08250	COG0709	Synthesizes selenophosphate from selenide and ATP
HUE88_RS08260	COG1921	L-seryl-tRNASec selenium transferase activity
HUE88_RS08275	COG3273	potassium ion transport
HUE88_RS08275	COG0471	metal ion transport
HUE88_RS08285	COG4974	Belongs to the 'phage' integrase family
HUE88_RS08335	COG0275	rRNA processing
HUE88_RS08340	COG2205	protein histidine kinase activity
HUE88_RS08340	COG2198	Histidine kinase
HUE88_RS08340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE88_RS08340	COG0784	Response regulator, receiver
HUE88_RS08345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUE88_RS08350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUE88_RS08355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUE88_RS08375	COG2884	Cell division ATP-binding protein ftsE
HUE88_RS08380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUE88_RS08390	COG0564	pseudouridine synthase activity
HUE88_RS08395	COG0772	Belongs to the SEDS family
HUE88_RS08400	COG2703	oxygen carrier activity
HUE88_RS08435	COG1058	Belongs to the CinA family
HUE88_RS08435	COG1546	Belongs to the CinA family
HUE88_RS08440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUE88_RS08445	COG0154	amidase activity
HUE88_RS08455	COG0517	IMP dehydrogenase activity
HUE88_RS08455	COG0516	GMP reductase activity
HUE88_RS08460	COG1716	ATPase activity
HUE88_RS08460	COG5001	Diguanylate cyclase
HUE88_RS08465	COG1714	RDD family
HUE88_RS08475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUE88_RS08500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUE88_RS08510	COG0436	Aminotransferase
HUE88_RS08530	COG1193	negative regulation of DNA recombination
HUE88_RS08535	COG0659	secondary active sulfate transmembrane transporter activity
HUE88_RS08540	COG2081	HI0933 family
HUE88_RS08545	COG1704	LemA family
HUE88_RS08695	COG0525	valine-tRNA ligase activity
HUE88_RS08700	COG0659	secondary active sulfate transmembrane transporter activity
HUE88_RS08710	COG2200	EAL domain
HUE88_RS08710	COG2199	diguanylate cyclase activity
HUE88_RS08720	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HUE88_RS08730	COG0134	indole-3-glycerol-phosphate synthase activity
HUE88_RS08740	COG0727	PFAM Uncharacterised protein family (UPF0153)
HUE88_RS08745	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUE88_RS08750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HUE88_RS08755	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUE88_RS08760	COG1959	2 iron, 2 sulfur cluster binding
HUE88_RS08765	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUE88_RS08770	COG2404	hydrolase activity, acting on ester bonds
HUE88_RS08785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUE88_RS08795	COG1758	RNA polymerase activity
HUE88_RS08800	COG0528	UMP kinase activity
HUE88_RS08805	COG2703	oxygen carrier activity
HUE88_RS08810	COG1959	2 iron, 2 sulfur cluster binding
HUE88_RS08815	COG2010	Cytochrome c
HUE88_RS08820	COG3256	nitric oxide reductase
HUE88_RS08830	COG0714	Associated with various cellular activities
HUE88_RS08835	COG0494	nUDIX hydrolase
HUE88_RS08850	COG0513	Belongs to the DEAD box helicase family
HUE88_RS08855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUE88_RS08860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUE88_RS08865	COG0500	methyltransferase
HUE88_RS08870	COG2066	Belongs to the glutaminase family
HUE88_RS08885	COG0243	molybdopterin cofactor binding
HUE88_RS08900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUE88_RS08910	COG0339	signal peptide processing
HUE88_RS08920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUE88_RS08945	COG0482	sulfurtransferase activity
HUE88_RS08950	COG1611	Belongs to the LOG family
HUE88_RS08955	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE88_RS08955	COG1776	CheC inhibitor of MCP methylation
HUE88_RS08965	COG1191	sigma factor activity
HUE88_RS08975	COG0455	bacterial-type flagellum organization
HUE88_RS08980	COG1419	protein localization to endoplasmic reticulum
HUE88_RS08985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUE88_RS08990	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUE88_RS08995	COG0402	S-adenosylhomocysteine deaminase activity
HUE88_RS09000	COG0616	signal peptide processing
HUE88_RS09010	COG1570	exodeoxyribonuclease VII activity
HUE88_RS09015	COG2226	methyltransferase
HUE88_RS09020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUE88_RS09020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUE88_RS09025	COG0779	Required for maturation of 30S ribosomal subunits
HUE88_RS09030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUE88_RS09035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUE88_RS09045	COG0083	homoserine kinase activity
HUE88_RS09055	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HUE88_RS09070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUE88_RS09075	COG0157	Belongs to the NadC ModD family
HUE88_RS09090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUE88_RS09100	COG0745	RESPONSE REGULATOR receiver
HUE88_RS09105	COG0642	Histidine kinase
HUE88_RS09110	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUE88_RS09170	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUE88_RS09175	COG0287	Prephenate dehydrogenase
HUE88_RS09185	COG2304	oxidoreductase activity
HUE88_RS09205	COG0714	Associated with various cellular activities
HUE88_RS09285	COG0004	ammonium transporteR
HUE88_RS09290	COG0347	Belongs to the P(II) protein family
HUE88_RS09295	COG0004	ammonium transporteR
HUE88_RS09320	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUE88_RS09330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUE88_RS09335	COG0731	radical SAM domain protein
HUE88_RS09365	COG4067	protein conserved in archaea
HUE88_RS09365	COG0189	ligase activity
HUE88_RS09380	COG0189	ligase activity
HUE88_RS09390	COG2239	Acts as a magnesium transporter
HUE88_RS09395	COG0387	Pfam Sodium calcium exchanger
HUE88_RS09415	COG0242	peptide deformylase activity
HUE88_RS09430	COG0308	aminopeptidase N
HUE88_RS09435	COG0439	Biotin carboxylase
HUE88_RS09445	COG0418	dihydroorotase activity
HUE88_RS09460	COG0811	peptide transport
HUE88_RS09465	COG0848	biopolymer transport protein
HUE88_RS09535	COG1733	regulation of RNA biosynthetic process
HUE88_RS09540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE88_RS09585	COG1309	transcriptional regulator
HUE88_RS09600	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HUE88_RS09605	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HUE88_RS09615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HUE88_RS09635	COG0459	protein refolding
HUE88_RS09640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUE88_RS09650	COG1136	(ABC) transporter
HUE88_RS09650	COG0577	efflux transmembrane transporter activity
HUE88_RS09700	COG0582	viral genome integration into host DNA
HUE88_RS09745	COG1278	Cold shock
HUE88_RS09770	COG0564	pseudouridine synthase activity
HUE88_RS09775	COG0513	Belongs to the DEAD box helicase family
HUE88_RS09785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUE88_RS09790	COG0247	lactate metabolic process
HUE88_RS09795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUE88_RS09800	COG1132	(ABC) transporter
HUE88_RS09865	COG0438	transferase activity, transferring glycosyl groups
HUE88_RS09895	COG3408	Glycogen debranching enzyme
HUE88_RS09895	COG3119	arylsulfatase activity
HUE88_RS09920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUE88_RS09920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUE88_RS09955	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUE88_RS10000	COG0512	Glutamine amidotransferase of anthranilate synthase
HUE88_RS10005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE88_RS10010	COG4786	Flagellar basal body rod
HUE88_RS10010	COG1256	bacterial-type flagellum assembly
HUE88_RS10025	COG3951	Flagellar rod assembly protein muramidase FlgJ
HUE88_RS10030	COG1706	bacterial-type flagellum-dependent cell motility
HUE88_RS10035	COG0742	ribosomal rna small subunit methyltransferase
HUE88_RS10045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUE88_RS10060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUE88_RS10070	COG0484	heat shock protein binding
HUE88_RS10080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUE88_RS10095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUE88_RS10100	COG0443	Heat shock 70 kDa protein
HUE88_RS10120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUE88_RS10135	COG0527	aspartate kinase activity
HUE88_RS10140	COG0494	nUDIX hydrolase
HUE88_RS10145	COG0840	transmembrane signaling receptor activity
HUE88_RS10150	COG0840	transmembrane signaling receptor activity
HUE88_RS10150	COG3290	protein histidine kinase activity
HUE88_RS10155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUE88_RS10160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUE88_RS10165	COG0805	protein transport
HUE88_RS10170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUE88_RS10180	COG2861	carbohydrate metabolic process
HUE88_RS10185	COG0360	Binds together with S18 to 16S ribosomal RNA
HUE88_RS10190	COG0629	single-stranded DNA binding
HUE88_RS10195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUE88_RS10200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUE88_RS10200	COG3153	acetyltransferase
HUE88_RS10215	COG0560	Phosphoserine phosphatase
HUE88_RS10225	COG5001	Diguanylate cyclase
HUE88_RS10230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUE88_RS10240	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUE88_RS10250	COG1187	pseudouridine synthase activity
HUE88_RS10260	COG0688	phosphatidylethanolamine metabolic process
HUE88_RS10265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE88_RS10270	COG2264	protein methyltransferase activity
HUE88_RS10275	COG0745	RESPONSE REGULATOR receiver
HUE88_RS10280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUE88_RS10285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUE88_RS10290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUE88_RS10300	COG0628	permease
HUE88_RS10305	COG2255	four-way junction helicase activity
HUE88_RS10310	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUE88_RS10320	COG0159	tryptophan synthase activity
HUE88_RS10340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUE88_RS10345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUE88_RS10355	COG0706	membrane insertase activity
HUE88_RS10360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUE88_RS10365	COG0594	ribonuclease P activity
HUE88_RS10370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUE88_RS10380	COG0542	response to heat
HUE88_RS10395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUE88_RS10400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUE88_RS10415	COG2226	methyltransferase
HUE88_RS10450	COG0776	regulation of translation
HUE88_RS10460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUE88_RS10465	COG0306	phosphate transporter
HUE88_RS10470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUE88_RS10495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUE88_RS10520	COG0793	Belongs to the peptidase S41A family
HUE88_RS10525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUE88_RS10530	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUE88_RS10535	COG0047	phosphoribosylformylglycinamidine synthase activity
HUE88_RS10545	COG0204	Acyl-transferase
HUE88_RS10550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUE88_RS10560	COG1132	(ABC) transporter
HUE88_RS10570	COG3787	Belongs to the UPF0306 family
HUE88_RS10580	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HUE88_RS10595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUE88_RS10605	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUE88_RS10610	COG1766	The M ring may be actively involved in energy transduction
HUE88_RS10615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUE88_RS10620	COG1605	Chorismate mutase
HUE88_RS10620	COG0077	Prephenate dehydratase
HUE88_RS10625	COG0647	UMP catabolic process
HUE88_RS10630	COG0019	diaminopimelate decarboxylase activity
HUE88_RS10640	COG0193	aminoacyl-tRNA hydrolase activity
HUE88_RS10645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUE88_RS10675	COG0540	Belongs to the ATCase OTCase family
HUE88_RS10680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUE88_RS10685	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUE88_RS10690	COG0542	response to heat
HUE88_RS10695	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HUE88_RS10735	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUE88_RS10740	COG0335	large ribosomal subunit rRNA binding
HUE88_RS10745	COG0336	Belongs to the RNA methyltransferase TrmD family
HUE88_RS10750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUE88_RS10760	COG0228	four-way junction DNA binding
HUE88_RS10765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUE88_RS10770	COG1671	Belongs to the UPF0178 family
HUE88_RS10775	COG2827	Endonuclease containing a URI domain
HUE88_RS10780	COG0564	pseudouridine synthase activity
HUE88_RS10785	COG1519	Transferase
HUE88_RS10795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUE88_RS10805	COG0739	heme binding
HUE88_RS10810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUE88_RS10830	COG1002	Type II restriction enzyme, methylase subunits
HUE88_RS10835	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUE88_RS10840	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HUE88_RS10845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUE88_RS10850	COG0210	DNA helicase
HUE88_RS10865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUE88_RS10875	COG3706	GGDEF domain
HUE88_RS10885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUE88_RS10890	COG1185	polyribonucleotide nucleotidyltransferase activity
HUE88_RS10900	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HUE88_RS10915	COG5002	protein histidine kinase activity
HUE88_RS10925	COG0840	transmembrane signaling receptor activity
HUE88_RS10935	COG0519	Catalyzes the synthesis of GMP from XMP
HUE88_RS10935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUE88_RS10945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUE88_RS10960	COG0322	excinuclease ABC activity
HUE88_RS10965	COG3852	Histidine kinase
HUE88_RS10980	COG0745	RESPONSE REGULATOR receiver
HUE88_RS10985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUE88_RS10990	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUE88_RS10995	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HUE88_RS11020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUE88_RS11025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUE88_RS11030	COG0612	Peptidase, M16
HUE88_RS11035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUE88_RS11045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUE88_RS11050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUE88_RS11055	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HUE88_RS11075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HUE88_RS11085	COG3437	response regulator, receiver
HUE88_RS11085	COG0784	Response regulator, receiver
HUE88_RS11090	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HUE88_RS11105	COG1160	GTP binding
HUE88_RS11110	COG1981	membrane
HUE88_RS11130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUE88_RS11135	COG0113	porphobilinogen synthase activity
HUE88_RS11140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUE88_RS11145	COG0357	Ribosomal RNA small subunit methyltransferase G
HUE88_RS11160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUE88_RS11165	COG2957	Belongs to the agmatine deiminase family
HUE88_RS11185	COG2199	diguanylate cyclase activity
HUE88_RS11185	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUE88_RS11190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUE88_RS11195	COG0305	Participates in initiation and elongation during chromosome replication
HUE88_RS11200	COG0658	competence protein
HUE88_RS11200	COG2333	competence protein COMEC
HUE88_RS11205	COG1295	ribonuclease BN
HUE88_RS11210	COG0277	FAD linked oxidase domain protein
HUE88_RS11220	COG0739	heme binding
HUE88_RS11230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUE88_RS11250	COG1815	bacterial-type flagellum-dependent cell motility
HUE88_RS11255	COG1558	bacterial-type flagellum-dependent cell motility
HUE88_RS11270	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUE88_RS11275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUE88_RS11300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUE88_RS11305	COG0049	tRNA binding
HUE88_RS11310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUE88_RS11315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUE88_RS11320	COG0085	RNA polymerase activity
HUE88_RS11325	COG0222	ribosome binding
HUE88_RS11330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUE88_RS11335	COG0081	regulation of translation
HUE88_RS11340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUE88_RS11345	COG0250	Participates in transcription elongation, termination and antitermination
HUE88_RS11360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUE88_RS11365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUE88_RS11410	COG3022	response to hydroperoxide
HUE88_RS11460	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HUE88_RS11465	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HUE88_RS11470	COG0732	type I restriction modification DNA specificity domain
HUE88_RS11485	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUE88_RS11505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE88_RS11525	COG3706	GGDEF domain
HUE88_RS11530	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUE88_RS11545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUE88_RS11560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUE88_RS11565	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUE88_RS11575	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUE88_RS11595	COG0203	ribosomal protein L17
HUE88_RS11600	COG0202	RNA polymerase activity
HUE88_RS11605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUE88_RS11610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUE88_RS11615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUE88_RS11620	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUE88_RS11640	COG0640	Transcriptional regulator
HUE88_RS11645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUE88_RS11650	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUE88_RS11685	COG0133	tryptophan synthase activity
HUE88_RS11705	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUE88_RS11710	COG0024	Methionine aminopeptidase
HUE88_RS11715	COG0201	protein transport
HUE88_RS11720	COG0200	Binds to the 23S rRNA
HUE88_RS11725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUE88_RS11730	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUE88_RS11735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUE88_RS11740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUE88_RS11745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUE88_RS11750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUE88_RS11755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUE88_RS11760	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUE88_RS11765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUE88_RS11770	COG0255	Belongs to the universal ribosomal protein uL29 family
HUE88_RS11775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUE88_RS11780	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUE88_RS11785	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUE88_RS11790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUE88_RS11795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUE88_RS11800	COG0089	rRNA binding
HUE88_RS11805	COG0088	Forms part of the polypeptide exit tunnel
HUE88_RS11810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUE88_RS11815	COG0051	transcription antitermination factor activity, RNA binding
HUE88_RS11825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUE88_RS11855	COG3258	Cytochrome c
HUE88_RS11875	COG2205	protein histidine kinase activity
HUE88_RS11880	COG0745	RESPONSE REGULATOR receiver
HUE88_RS11895	COG0303	'Molybdopterin
HUE88_RS11900	COG0314	molybdopterin synthase activity
HUE88_RS11910	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUE88_RS11920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUE88_RS11925	COG0297	glycogen (starch) synthase activity
HUE88_RS11930	COG1940	carbohydrate kinase activity
HUE88_RS11935	COG0297	glycogen (starch) synthase activity
HUE88_RS11945	COG1449	Belongs to the glycosyl hydrolase 57 family
HUE88_RS11955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUE88_RS11965	COG0205	6-phosphofructokinase activity
HUE88_RS11970	COG0058	SHG alpha-glucan phosphorylase activity
HUE88_RS11975	COG0166	Belongs to the GPI family
HUE88_RS12005	COG2199	diguanylate cyclase activity
HUE88_RS12005	COG2203	Gaf domain
HUE88_RS12030	COG0582	viral genome integration into host DNA
HUE88_RS12050	COG0732	type I restriction modification DNA specificity domain
HUE88_RS12075	COG1090	epimerase
HUE88_RS12080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE88_RS12085	COG0752	glycyl-tRNA synthetase alpha subunit
HUE88_RS12100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUE88_RS12105	COG0826	peptidase U32
HUE88_RS12115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUE88_RS12120	COG3118	belongs to the thioredoxin family
HUE88_RS12130	COG0492	ferredoxin-NADP+ reductase activity
HUE88_RS12135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUE88_RS12140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HUE88_RS12145	COG1242	4 iron, 4 sulfur cluster binding
HUE88_RS12160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUE88_RS12160	COG0140	phosphoribosyl-ATP diphosphatase activity
HUE88_RS12190	COG0573	inorganic phosphate transmembrane transporter activity
HUE88_RS12200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUE88_RS12210	COG0174	glutamine synthetase
HUE88_RS12215	COG2198	Histidine kinase
HUE88_RS12215	COG0784	Response regulator, receiver
HUE88_RS12215	COG2205	protein histidine kinase activity
HUE88_RS12220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUE88_RS12225	COG0745	RESPONSE REGULATOR receiver
HUE88_RS12230	COG0642	Histidine kinase
HUE88_RS12245	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HUE88_RS12250	COG4172	Belongs to the ABC transporter superfamily
HUE88_RS12255	COG0156	8-amino-7-oxononanoate synthase activity
HUE88_RS12265	COG0424	maF-like protein
HUE88_RS12275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUE88_RS12295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUE88_RS12295	COG1333	cytochrome c biogenesis protein
HUE88_RS12310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUE88_RS12310	COG1333	cytochrome c biogenesis protein
HUE88_RS12315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUE88_RS12315	COG1333	cytochrome c biogenesis protein
HUE88_RS12380	COG1012	belongs to the aldehyde dehydrogenase family
HUE88_RS12395	COG0792	nuclease activity
HUE88_RS12400	COG3383	formate dehydrogenase (NAD+) activity
HUE88_RS12405	COG0300	oxidoreductase activity
HUE88_RS12410	COG0460	homoserine dehydrogenase
HUE88_RS12415	COG0436	Aminotransferase
HUE88_RS12430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE88_RS12435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUE88_RS12440	COG0254	rRNA binding
HUE88_RS12455	COG0303	'Molybdopterin
HUE88_RS12465	COG0602	queuosine metabolic process
HUE88_RS12475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUE88_RS12515	COG0445	tRNA wobble uridine modification
HUE88_RS12540	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUE88_RS12560	COG1854	S-ribosylhomocysteine lyase activity
HUE88_RS12565	COG0840	transmembrane signaling receptor activity
HUE88_RS12570	COG2201	protein-glutamate methylesterase activity
HUE88_RS12580	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUE88_RS12585	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUE88_RS12590	COG1144	Oxidoreductase
HUE88_RS12595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUE88_RS12610	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUE88_RS12615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUE88_RS12630	COG1074	ATP-dependent DNA helicase activity
HUE88_RS12680	COG2010	Cytochrome c
HUE88_RS12695	COG3278	Belongs to the heme-copper respiratory oxidase family
HUE88_RS12700	COG0505	Belongs to the CarA family
HUE88_RS12720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUE88_RS12725	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HUE88_RS12730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUE88_RS12735	COG1968	undecaprenyl-diphosphatase activity
HUE88_RS12740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUE88_RS12750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUE88_RS12755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUE88_RS12760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUE88_RS12765	COG0022	dehydrogenase e1 component
HUE88_RS12765	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUE88_RS12770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUE88_RS12775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUE88_RS12785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUE88_RS12790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUE88_RS12795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUE88_RS12800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUE88_RS12805	COG2814	Major facilitator Superfamily
HUE88_RS12810	COG1132	(ABC) transporter
HUE88_RS12815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUE88_RS12825	COG0129	dihydroxy-acid dehydratase activity
HUE88_RS12890	COG1404	Belongs to the peptidase S8 family
HUE88_RS12950	COG1196	nuclear chromosome segregation
HUE88_RS12950	COG3264	Mechanosensitive ion channel
HUE88_RS12965	COG0702	epimerase
HUE88_RS12975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUE88_RS13015	COG0745	RESPONSE REGULATOR receiver
HUE88_RS13020	COG2022	thiamine diphosphate biosynthetic process
HUE88_RS13025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUE88_RS13025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUE88_RS13035	COG1858	cytochrome C peroxidase
HUE88_RS13040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUE88_RS13045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUE88_RS13045	COG0517	IMP dehydrogenase activity
HUE88_RS13050	COG1187	pseudouridine synthase activity
HUE88_RS13055	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HUE88_RS13055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUE88_RS13060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUE88_RS13065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUE88_RS13085	COG0300	oxidoreductase activity
HUE88_RS13100	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HUE88_RS13110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUE88_RS13115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUE88_RS13120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUE88_RS13125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUE88_RS13135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUE88_RS13140	COG0475	glutathione-regulated potassium exporter activity
HUE88_RS13140	COG0569	domain protein
HUE88_RS13165	COG0577	efflux transmembrane transporter activity
HUE88_RS13165	COG1136	(ABC) transporter
HUE88_RS13180	COG1408	metallophosphoesterase
HUE88_RS13220	COG0148	phosphopyruvate hydratase activity
HUE88_RS13225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUE88_RS13230	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUE88_RS13240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUE88_RS13245	COG2906	2 iron, 2 sulfur cluster binding
HUE88_RS13245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HUE88_RS13245	COG0822	iron-sulfur transferase activity
HUE88_RS13250	COG1104	cysteine desulfurase activity
HUE88_RS13270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUE88_RS13275	COG2885	chlorophyll binding
HUE88_RS13280	COG0746	molybdenum cofactor guanylyltransferase activity
HUE88_RS13285	COG0315	cyclic pyranopterin monophosphate synthase activity
HUE88_RS13300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUE88_RS13305	COG0571	ribonuclease III activity
HUE88_RS13310	COG0328	RNA-DNA hybrid ribonuclease activity
HUE88_RS13325	COG2855	membrane
HUE88_RS13345	COG1410	methionine synthase
HUE88_RS13345	COG0646	methionine synthase
HUE88_RS13350	COG2197	response regulator
HUE88_RS13355	COG3852	Histidine kinase
HUE88_RS13360	COG0606	chelatase, subunit chli
HUE88_RS13365	COG0242	peptide deformylase activity
HUE88_RS13375	COG0740	serine-type endopeptidase activity
HUE88_RS13380	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUE88_RS13385	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUE88_RS13390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUE88_RS13395	COG0268	Binds directly to 16S ribosomal RNA
HUE88_RS13400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUE88_RS13405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUE88_RS13410	COG0237	dephospho-CoA kinase activity
HUE88_RS13415	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUE88_RS13430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUE88_RS13470	COG0670	Belongs to the BI1 family
HUE88_RS13475	COG0352	thiamine-phosphate diphosphorylase activity
HUE88_RS13515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUE88_RS13520	COG1121	(ABC) transporter
HUE88_RS13525	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUE88_RS13525	COG3443	Belongs to the bacterial solute-binding protein 9 family
HUE88_RS13530	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUE88_RS13535	COG0233	cytoplasmic translational termination
HUE88_RS13540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUE88_RS13545	COG1472	Belongs to the glycosyl hydrolase 3 family
HUE88_RS13555	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUE88_RS13580	COG0676	glucose-6-phosphate 1-epimerase activity
HUE88_RS13605	COG0504	CTP synthase activity
HUE88_RS13610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUE88_RS13610	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUE88_RS13630	COG1157	protein secretion by the type III secretion system
HUE88_RS13645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUE88_RS13650	COG0107	imidazoleglycerol-phosphate synthase activity
HUE88_RS13660	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUE88_RS13670	COG0564	pseudouridine synthase activity
HUE88_RS13675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUE88_RS13680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUE88_RS13690	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HUE88_RS13700	COG3118	belongs to the thioredoxin family
HUE88_RS13705	COG0372	Belongs to the citrate synthase family
HUE88_RS13710	COG3123	guanosine phosphorylase activity
HUE88_RS13720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group