locus-tag	class	description
SYNTR_RS00020	COG0463	Glycosyl transferase, family 2
SYNTR_RS00020	COG0457	Tetratricopeptide repeat
SYNTR_RS00045	COG0596	Alpha beta hydrolase
SYNTR_RS00065	COG0110	maltose O-acetyltransferase activity
SYNTR_RS00080	COG3842	ATPase activity
SYNTR_RS00090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNTR_RS00095	COG0477	Major facilitator Superfamily
SYNTR_RS00100	COG2814	Major facilitator Superfamily
SYNTR_RS00135	COG2414	aldehyde ferredoxin oxidoreductase
SYNTR_RS00140	COG0753	catalase activity
SYNTR_RS00140	COG0693	protein deglycase activity
SYNTR_RS00170	COG3852	Histidine kinase
SYNTR_RS00190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNTR_RS00210	COG1131	(ABC) transporter
SYNTR_RS00230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SYNTR_RS00235	COG1993	acr, cog1993
SYNTR_RS00240	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SYNTR_RS00255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SYNTR_RS00275	COG0425	Belongs to the sulfur carrier protein TusA family
SYNTR_RS00280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYNTR_RS00285	COG1250	3-hydroxyacyl-CoA dehydrogenase
SYNTR_RS00290	COG0183	Belongs to the thiolase family
SYNTR_RS00295	COG1960	acyl-CoA dehydrogenase activity
SYNTR_RS00300	COG0427	acetyl-CoA hydrolase
SYNTR_RS00310	COG0840	transmembrane signaling receptor activity
SYNTR_RS00315	COG1250	3-hydroxyacyl-CoA dehydrogenase
SYNTR_RS00320	COG1960	acyl-CoA dehydrogenase activity
SYNTR_RS00335	COG3290	protein histidine kinase activity
SYNTR_RS00335	COG3829	transcription factor binding
SYNTR_RS00340	COG0183	Belongs to the thiolase family
SYNTR_RS00345	COG1024	Enoyl-CoA hydratase
SYNTR_RS00350	COG1960	acyl-CoA dehydrogenase activity
SYNTR_RS00355	COG2223	nitrite transmembrane transporter activity
SYNTR_RS00360	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SYNTR_RS00365	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SYNTR_RS00370	COG1028	Short-chain dehydrogenase reductase Sdr
SYNTR_RS00385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYNTR_RS00390	COG2183	response to ionizing radiation
SYNTR_RS00400	COG0745	RESPONSE REGULATOR receiver
SYNTR_RS00405	COG2205	protein histidine kinase activity
SYNTR_RS00405	COG2770	Histidine kinase
SYNTR_RS00420	COG2223	nitrite transmembrane transporter activity
SYNTR_RS00425	COG0351	phosphomethylpyrimidine kinase
SYNTR_RS00430	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SYNTR_RS00435	COG0352	thiamine-phosphate diphosphorylase activity
SYNTR_RS00455	COG1307	EDD domain protein, DegV family
SYNTR_RS00465	COG2720	vancomycin resistance protein
SYNTR_RS00470	COG0513	Belongs to the DEAD box helicase family
SYNTR_RS00475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYNTR_RS00480	COG0390	transport system, permease component
SYNTR_RS00525	COG1331	Highly conserved protein containing a thioredoxin domain
SYNTR_RS00530	COG1959	2 iron, 2 sulfur cluster binding
SYNTR_RS00535	COG0735	belongs to the Fur family
SYNTR_RS00545	COG1121	(ABC) transporter
SYNTR_RS00550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYNTR_RS00555	COG0778	Nitroreductase
SYNTR_RS00560	COG0825	malonyl-CoA metabolic process
SYNTR_RS00565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SYNTR_RS00570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SYNTR_RS00575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SYNTR_RS00580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYNTR_RS00585	COG1028	Short-chain dehydrogenase reductase Sdr
SYNTR_RS00590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SYNTR_RS00600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYNTR_RS00605	COG2070	2-Nitropropane dioxygenase
SYNTR_RS00610	COG1376	ErfK ybiS ycfS ynhG family protein
SYNTR_RS00615	COG2186	Transcriptional regulator
SYNTR_RS00655	COG0697	spore germination
SYNTR_RS00685	COG2239	Acts as a magnesium transporter
SYNTR_RS00690	COG2205	protein histidine kinase activity
SYNTR_RS00690	COG2198	Histidine kinase
SYNTR_RS00690	COG0784	Response regulator, receiver
SYNTR_RS00700	COG0835	chemotaxis
SYNTR_RS00705	COG0736	holo-[acyl-carrier-protein] synthase activity
SYNTR_RS00710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SYNTR_RS00710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SYNTR_RS00715	COG0517	IMP dehydrogenase activity
SYNTR_RS00715	COG0516	GMP reductase activity
SYNTR_RS00720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SYNTR_RS00725	COG0864	Transcriptional regulator
SYNTR_RS00730	COG2337	Toxic component of a toxin-antitoxin (TA) module
SYNTR_RS00735	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SYNTR_RS00740	COG1228	amidohydrolase
SYNTR_RS00755	COG1376	ErfK ybiS ycfS ynhG family protein
SYNTR_RS00760	COG1573	uracil-dna glycosylase
SYNTR_RS00765	COG0802	atpase or kinase
SYNTR_RS00770	COG1214	PFAM Peptidase M22, glycoprotease
SYNTR_RS00775	COG0456	acetyltransferase
SYNTR_RS00780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SYNTR_RS00790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SYNTR_RS00795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SYNTR_RS00800	COG0315	cyclic pyranopterin monophosphate synthase activity
SYNTR_RS00810	COG0521	Mo-molybdopterin cofactor biosynthetic process
SYNTR_RS00815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SYNTR_RS00820	COG0459	protein refolding
SYNTR_RS00835	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SYNTR_RS00840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SYNTR_RS00840	COG0519	Catalyzes the synthesis of GMP from XMP
SYNTR_RS00845	COG2414	aldehyde ferredoxin oxidoreductase
SYNTR_RS00855	COG1033	growth of symbiont in host cell
SYNTR_RS00855	COG2409	Drug exporters of the RND superfamily
SYNTR_RS00860	COG2409	Drug exporters of the RND superfamily
SYNTR_RS00860	COG1033	growth of symbiont in host cell
SYNTR_RS00880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SYNTR_RS00905	COG2909	trisaccharide binding
SYNTR_RS00910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SYNTR_RS01020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SYNTR_RS01025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SYNTR_RS01030	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SYNTR_RS01035	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SYNTR_RS01040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SYNTR_RS01045	COG0138	bifunctional purine biosynthesis protein purh
SYNTR_RS01050	COG0151	Belongs to the GarS family
SYNTR_RS01060	COG4496	protein, YerC YecD
SYNTR_RS01065	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SYNTR_RS01070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SYNTR_RS01080	COG0131	Imidazoleglycerol-phosphate dehydratase
SYNTR_RS01085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SYNTR_RS01090	COG0107	imidazoleglycerol-phosphate synthase activity
SYNTR_RS01120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SYNTR_RS01125	COG0109	protoheme IX farnesyltransferase activity
SYNTR_RS01130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYNTR_RS01135	COG0154	amidase activity
SYNTR_RS01140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SYNTR_RS01145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYNTR_RS01155	COG0066	3-isopropylmalate dehydratase activity
SYNTR_RS01160	COG0538	isocitrate dehydrogenase activity
SYNTR_RS01165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SYNTR_RS01170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SYNTR_RS01180	COG0784	Response regulator, receiver
SYNTR_RS01180	COG2205	protein histidine kinase activity
SYNTR_RS01195	COG1983	PspC domain protein
SYNTR_RS01225	COG0517	IMP dehydrogenase activity
SYNTR_RS01245	COG2199	diguanylate cyclase activity
SYNTR_RS01245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SYNTR_RS01290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYNTR_RS01290	COG5322	oxidoreductase activity
SYNTR_RS01305	COG3279	Response regulator of the LytR AlgR family
SYNTR_RS01310	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNTR_RS01315	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNTR_RS01315	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
SYNTR_RS01325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SYNTR_RS01335	COG1924	4 iron, 4 sulfur cluster binding
SYNTR_RS01340	COG1234	tRNA 3'-trailer cleavage
SYNTR_RS01350	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SYNTR_RS01350	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SYNTR_RS01355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SYNTR_RS01360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SYNTR_RS01365	COG0622	Phosphoesterase
SYNTR_RS01370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SYNTR_RS01375	COG0509	glycine decarboxylation via glycine cleavage system
SYNTR_RS01380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYNTR_RS01385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SYNTR_RS01390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SYNTR_RS01400	COG3285	dna ligase
SYNTR_RS01400	COG1793	dna ligase
SYNTR_RS01405	COG1793	dna ligase
SYNTR_RS01410	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SYNTR_RS01440	COG3118	belongs to the thioredoxin family
SYNTR_RS01445	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SYNTR_RS01450	COG0482	sulfurtransferase activity
SYNTR_RS01465	COG0628	permease
SYNTR_RS01470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SYNTR_RS01475	COG4472	Bacterial protein of unknown function (DUF965)
SYNTR_RS01485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SYNTR_RS01490	COG3906	Belongs to the UPF0473 family
SYNTR_RS01495	COG2720	vancomycin resistance protein
SYNTR_RS01500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SYNTR_RS01505	COG0826	peptidase U32
SYNTR_RS01515	COG0768	penicillin binding
SYNTR_RS01520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SYNTR_RS01525	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SYNTR_RS01530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SYNTR_RS01530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SYNTR_RS01535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SYNTR_RS01535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SYNTR_RS01550	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYNTR_RS01560	COG0006	proline dipeptidase activity
SYNTR_RS01585	COG1085	galactose-1-phosphate uridylyltransferase
SYNTR_RS01590	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SYNTR_RS01595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SYNTR_RS01605	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SYNTR_RS01610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SYNTR_RS01615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SYNTR_RS01620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SYNTR_RS01625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SYNTR_RS01630	COG1459	type II secretion system
SYNTR_RS01640	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SYNTR_RS01675	COG0312	modulator of DNA gyrase
SYNTR_RS01680	COG0312	modulator of DNA gyrase
SYNTR_RS01690	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SYNTR_RS01695	COG0006	proline dipeptidase activity
SYNTR_RS01700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SYNTR_RS01710	COG3854	ATPases associated with a variety of cellular activities
SYNTR_RS01755	COG0439	Biotin carboxylase
SYNTR_RS01760	COG1302	Protein conserved in bacteria
SYNTR_RS01775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYNTR_RS01780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SYNTR_RS01785	COG1570	exodeoxyribonuclease VII activity
SYNTR_RS01790	COG1722	exodeoxyribonuclease VII activity
SYNTR_RS01805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SYNTR_RS01810	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SYNTR_RS01815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SYNTR_RS01820	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SYNTR_RS01825	COG1438	arginine binding
SYNTR_RS01830	COG0497	DNA recombination
SYNTR_RS01835	COG0750	zinc metalloprotease
SYNTR_RS01840	COG0745	RESPONSE REGULATOR receiver
SYNTR_RS01865	COG2195	Cleaves the N-terminal amino acid of tripeptides
SYNTR_RS01880	COG1379	DNA repair
SYNTR_RS01895	COG1300	Membrane
SYNTR_RS01905	COG4974	Belongs to the 'phage' integrase family
SYNTR_RS01910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SYNTR_RS01920	COG1686	Belongs to the peptidase S11 family
SYNTR_RS01925	COG1366	Belongs to the anti-sigma-factor antagonist family
SYNTR_RS01930	COG2172	sigma factor antagonist activity
SYNTR_RS01950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYNTR_RS01965	COG0697	spore germination
SYNTR_RS01980	COG1924	4 iron, 4 sulfur cluster binding
SYNTR_RS01985	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SYNTR_RS01995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SYNTR_RS02000	COG0776	regulation of translation
SYNTR_RS02020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SYNTR_RS02045	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SYNTR_RS02070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SYNTR_RS02075	COG0735	belongs to the Fur family
SYNTR_RS02080	COG1137	ATPase activity
SYNTR_RS02085	COG0719	Fe-S assembly protein
SYNTR_RS02100	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SYNTR_RS02105	COG0010	Belongs to the arginase family
SYNTR_RS02120	COG4176	ABC-type proline glycine betaine transport system permease component
SYNTR_RS02125	COG2113	Glycine betaine
SYNTR_RS02135	COG0180	Tryptophanyl-tRNA synthetase
SYNTR_RS02140	COG1846	Transcriptional regulator
SYNTR_RS02155	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SYNTR_RS02165	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SYNTR_RS02170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SYNTR_RS02175	COG0163	prenyltransferase activity
SYNTR_RS02180	COG0142	geranyltranstransferase activity
SYNTR_RS02185	COG0805	protein transport
SYNTR_RS02190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYNTR_RS02195	COG1648	precorrin-2 dehydrogenase activity
SYNTR_RS02195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SYNTR_RS02200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SYNTR_RS02205	COG0181	hydroxymethylbilane synthase activity
SYNTR_RS02215	COG0535	radical SAM domain protein
SYNTR_RS02220	COG0113	porphobilinogen synthase activity
SYNTR_RS02225	COG0535	radical SAM domain protein
SYNTR_RS02230	COG1522	sequence-specific DNA binding
SYNTR_RS02235	COG1522	sequence-specific DNA binding
SYNTR_RS02240	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SYNTR_RS02245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SYNTR_RS02250	COG2086	electron transfer activity
SYNTR_RS02255	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SYNTR_RS02260	COG2181	nitrate reductase activity
SYNTR_RS02260	COG0247	lactate metabolic process
SYNTR_RS02265	COG0183	Belongs to the thiolase family
SYNTR_RS02270	COG1960	acyl-CoA dehydrogenase activity
SYNTR_RS02275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SYNTR_RS02280	COG0840	transmembrane signaling receptor activity
SYNTR_RS02285	COG3584	3D domain protein
SYNTR_RS02285	COG3583	domain protein
SYNTR_RS02290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SYNTR_RS02295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SYNTR_RS02300	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SYNTR_RS02305	COG1302	Protein conserved in bacteria
SYNTR_RS02310	COG1461	Dihydroxyacetone kinase
SYNTR_RS02315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SYNTR_RS02325	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SYNTR_RS02330	COG0742	ribosomal rna small subunit methyltransferase
SYNTR_RS02340	COG3314	Sporulation integral membrane protein YlbJ
SYNTR_RS02345	COG1752	Esterase of the alpha-beta hydrolase superfamily
SYNTR_RS02350	COG1323	Belongs to the UPF0348 family
SYNTR_RS02355	COG0280	phosphate acetyltransferase
SYNTR_RS02360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SYNTR_RS02370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SYNTR_RS02375	COG0416	fatty acid biosynthetic process
SYNTR_RS02380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SYNTR_RS02385	COG0571	ribonuclease III activity
SYNTR_RS02405	COG0552	protein localization to endoplasmic reticulum
SYNTR_RS02410	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SYNTR_RS02415	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SYNTR_RS02425	COG0402	S-adenosylhomocysteine deaminase activity
SYNTR_RS02435	COG0446	pyridine nucleotide-disulphide oxidoreductase
SYNTR_RS02440	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SYNTR_RS02465	COG0437	4 iron, 4 sulfur cluster binding
SYNTR_RS02475	COG1910	domain protein
SYNTR_RS02485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYNTR_RS02500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SYNTR_RS02500	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SYNTR_RS02505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SYNTR_RS02510	COG1490	D-aminoacyl-tRNA deacylase activity
SYNTR_RS02515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYNTR_RS02535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYNTR_RS02540	COG0124	histidyl-tRNA synthetase
SYNTR_RS02545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SYNTR_RS02555	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SYNTR_RS02565	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SYNTR_RS02575	COG0174	glutamine synthetase
SYNTR_RS02580	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SYNTR_RS02580	COG1796	DNA polymerase
SYNTR_RS02585	COG2001	Belongs to the MraZ family
SYNTR_RS02590	COG0275	rRNA processing
SYNTR_RS02600	COG0768	penicillin binding
SYNTR_RS02605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SYNTR_RS02610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SYNTR_RS02620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SYNTR_RS02625	COG0772	Belongs to the SEDS family
SYNTR_RS02630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SYNTR_RS02635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SYNTR_RS02640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYNTR_RS02645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SYNTR_RS02650	COG3879	Bacterial protein of unknown function (DUF881)
SYNTR_RS02655	COG3856	small basic protein
SYNTR_RS02665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SYNTR_RS02675	COG1191	sigma factor activity
SYNTR_RS02680	COG1191	sigma factor activity
SYNTR_RS02695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNTR_RS02710	COG0758	DNA mediated transformation
SYNTR_RS02715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SYNTR_RS02720	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SYNTR_RS02725	COG4974	Belongs to the 'phage' integrase family
SYNTR_RS02730	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SYNTR_RS02735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SYNTR_RS02745	COG1815	bacterial-type flagellum-dependent cell motility
SYNTR_RS02750	COG1558	bacterial-type flagellum-dependent cell motility
SYNTR_RS02755	COG1677	Flagellar hook-basal body complex protein FliE
SYNTR_RS02760	COG1766	The M ring may be actively involved in energy transduction
SYNTR_RS02765	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SYNTR_RS02775	COG1157	protein secretion by the type III secretion system
SYNTR_RS02795	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SYNTR_RS02810	COG1582	Flagellar protein (FlbD)
SYNTR_RS02820	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SYNTR_RS02825	COG1776	CheC inhibitor of MCP methylation
SYNTR_RS02825	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SYNTR_RS02830	COG2201	protein-glutamate methylesterase activity
SYNTR_RS02840	COG1338	Plays a role in the flagellum-specific transport system
SYNTR_RS02845	COG1987	bacterial-type flagellum assembly
SYNTR_RS02855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SYNTR_RS02860	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SYNTR_RS02865	COG1419	protein localization to endoplasmic reticulum
SYNTR_RS02880	COG2201	protein-glutamate methylesterase activity
SYNTR_RS02885	COG2198	Histidine kinase
SYNTR_RS02885	COG0643	Histidine kinase
SYNTR_RS02890	COG0835	chemotaxis
SYNTR_RS02895	COG1776	CheC inhibitor of MCP methylation
SYNTR_RS02900	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SYNTR_RS02905	COG1191	sigma factor activity
SYNTR_RS02920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYNTR_RS02925	COG0052	Belongs to the universal ribosomal protein uS2 family
SYNTR_RS02930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SYNTR_RS02935	COG0528	UMP kinase activity
SYNTR_RS02940	COG0233	cytoplasmic translational termination
SYNTR_RS02950	COG4589	Belongs to the CDS family
SYNTR_RS02955	COG0628	permease
SYNTR_RS02960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SYNTR_RS02965	COG0750	zinc metalloprotease
SYNTR_RS02970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SYNTR_RS02975	COG0442	prolyl-tRNA aminoacylation
SYNTR_RS02980	COG1285	pathogenesis
SYNTR_RS02985	COG2176	DNA-directed DNA polymerase activity
SYNTR_RS02990	COG0779	Required for maturation of 30S ribosomal subunits
SYNTR_RS02995	COG0195	Participates in both transcription termination and antitermination
SYNTR_RS03000	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SYNTR_RS03010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SYNTR_RS03015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SYNTR_RS03020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SYNTR_RS03025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SYNTR_RS03030	COG0196	riboflavin kinase activity
SYNTR_RS03035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SYNTR_RS03040	COG1185	polyribonucleotide nucleotidyltransferase activity
SYNTR_RS03045	COG2720	vancomycin resistance protein
SYNTR_RS03050	COG0726	polysaccharide deacetylase
SYNTR_RS03055	COG1686	Belongs to the peptidase S11 family
SYNTR_RS03060	COG0612	Peptidase, M16
SYNTR_RS03065	COG0756	dUTP diphosphatase activity
SYNTR_RS03080	COG0516	GMP reductase activity
SYNTR_RS03080	COG0517	IMP dehydrogenase activity
SYNTR_RS03090	COG1509	lysine 2,3-aminomutase activity
SYNTR_RS03115	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYNTR_RS03120	COG0840	transmembrane signaling receptor activity
SYNTR_RS03135	COG1067	ATP-dependent peptidase activity
SYNTR_RS03150	COG1739	Uncharacterized protein family UPF0029
SYNTR_RS03170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SYNTR_RS03180	COG1543	Belongs to the glycosyl hydrolase 57 family
SYNTR_RS03190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SYNTR_RS03205	COG1199	ATP-dependent helicase activity
SYNTR_RS03255	COG0432	Pfam Uncharacterised protein family UPF0047
SYNTR_RS03310	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SYNTR_RS03310	COG0617	tRNA 3'-terminal CCA addition
SYNTR_RS03310	COG0517	IMP dehydrogenase activity
SYNTR_RS03325	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SYNTR_RS03335	COG0602	queuosine metabolic process
SYNTR_RS03350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SYNTR_RS03360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYNTR_RS03485	COG0582	viral genome integration into host DNA
SYNTR_RS03490	COG0582	viral genome integration into host DNA
SYNTR_RS03500	COG1181	Belongs to the D-alanine--D-alanine ligase family
SYNTR_RS03510	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYNTR_RS03515	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SYNTR_RS03520	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SYNTR_RS03530	COG1615	UPF0182 protein
SYNTR_RS03540	COG0482	sulfurtransferase activity
SYNTR_RS03545	COG1683	Conserved Protein
SYNTR_RS03560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNTR_RS03570	COG1250	3-hydroxyacyl-CoA dehydrogenase
SYNTR_RS03580	COG0012	GTP binding
SYNTR_RS03585	COG0569	domain protein
SYNTR_RS03590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SYNTR_RS03595	COG0189	ligase activity
SYNTR_RS03635	COG0077	Prephenate dehydratase
SYNTR_RS03635	COG1605	Chorismate mutase
SYNTR_RS03640	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SYNTR_RS03650	COG5002	protein histidine kinase activity
SYNTR_RS03685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SYNTR_RS03690	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SYNTR_RS03695	COG0667	Aldo Keto reductase
SYNTR_RS03705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SYNTR_RS03715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SYNTR_RS03720	COG1335	isochorismatase
SYNTR_RS03730	COG0427	acetyl-CoA hydrolase
SYNTR_RS03740	COG1104	cysteine desulfurase activity
SYNTR_RS03750	COG0560	Phosphoserine phosphatase
SYNTR_RS03765	COG0628	permease
SYNTR_RS03770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SYNTR_RS03780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYNTR_RS03785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYNTR_RS03820	COG0493	'glutamate synthase
SYNTR_RS03830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SYNTR_RS03840	COG0822	iron-sulfur transferase activity
SYNTR_RS03845	COG1104	cysteine desulfurase activity
SYNTR_RS03850	COG1959	2 iron, 2 sulfur cluster binding
SYNTR_RS03860	COG2217	Heavy metal translocating P-type atpase
SYNTR_RS03865	COG0640	Transcriptional regulator
SYNTR_RS03875	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SYNTR_RS03880	COG3858	chitin binding
SYNTR_RS03885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYNTR_RS03900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SYNTR_RS03905	COG0321	lipoyl(octanoyl) transferase activity
SYNTR_RS03915	COG0697	spore germination
SYNTR_RS03925	COG0814	amino acid
SYNTR_RS03930	COG2814	Major facilitator Superfamily
SYNTR_RS03935	COG2814	Major facilitator Superfamily
SYNTR_RS03950	COG0803	Belongs to the bacterial solute-binding protein 9 family
SYNTR_RS03955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SYNTR_RS03960	COG1121	(ABC) transporter
SYNTR_RS03965	COG1321	iron dependent repressor
SYNTR_RS03970	COG0673	inositol 2-dehydrogenase activity
SYNTR_RS03985	COG1183	phosphatidylcholine synthase activity
SYNTR_RS03990	COG0688	phosphatidylethanolamine metabolic process
SYNTR_RS03995	COG1032	radical SAM domain protein
SYNTR_RS04000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SYNTR_RS04005	COG3875	lactate racemase activity
SYNTR_RS04010	COG0277	FAD linked oxidase domain protein
SYNTR_RS04015	COG0247	lactate metabolic process
SYNTR_RS04020	COG0037	tRNA processing
SYNTR_RS04025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYNTR_RS04040	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SYNTR_RS04045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SYNTR_RS04045	COG2111	Na H antiporter
SYNTR_RS04050	COG2111	Na H antiporter
SYNTR_RS04055	COG1006	Multisubunit Na H antiporter MnhC subunit
SYNTR_RS04060	COG0651	ATP synthesis coupled electron transport
SYNTR_RS04065	COG1863	multisubunit Na H antiporter MnhE subunit
SYNTR_RS04070	COG2212	antiporter activity
SYNTR_RS04075	COG1320	monovalent cation:proton antiporter activity
SYNTR_RS04080	COG0464	growth
SYNTR_RS04085	COG1923	regulation of RNA biosynthetic process
SYNTR_RS04090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SYNTR_RS04095	COG2521	methyltransferase
SYNTR_RS04095	COG2136	Putative SAM-dependent methyltransferase
SYNTR_RS04100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SYNTR_RS04110	COG0145	ligase activity
SYNTR_RS04115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SYNTR_RS04120	COG0194	GDP metabolic process
SYNTR_RS04130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNTR_RS04165	COG1120	ATPase activity
SYNTR_RS04170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SYNTR_RS04175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SYNTR_RS04210	COG2358	TRAP transporter, solute receptor (TAXI family
SYNTR_RS04220	COG1063	alcohol dehydrogenase
SYNTR_RS04235	COG0604	alcohol dehydrogenase
SYNTR_RS04255	COG0564	pseudouridine synthase activity
SYNTR_RS04260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SYNTR_RS04265	COG0778	Nitroreductase
SYNTR_RS04270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SYNTR_RS04295	COG0427	acetyl-CoA hydrolase
SYNTR_RS04315	COG1401	restriction endodeoxyribonuclease activity
SYNTR_RS04465	COG0740	serine-type endopeptidase activity
SYNTR_RS04470	COG4695	Portal protein
SYNTR_RS04495	COG1802	Transcriptional regulator
SYNTR_RS04495	COG4626	Terminase
SYNTR_RS04595	COG2176	DNA-directed DNA polymerase activity
SYNTR_RS04600	COG1518	maintenance of DNA repeat elements
SYNTR_RS04615	COG1857	crispr-associated protein
SYNTR_RS04640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SYNTR_RS04660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYNTR_RS04665	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SYNTR_RS04675	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SYNTR_RS04685	COG0305	Participates in initiation and elongation during chromosome replication
SYNTR_RS04695	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SYNTR_RS04705	COG0436	Aminotransferase
SYNTR_RS04710	COG1522	sequence-specific DNA binding
SYNTR_RS04745	COG0835	chemotaxis
SYNTR_RS04765	COG0840	transmembrane signaling receptor activity
SYNTR_RS04765	COG3290	protein histidine kinase activity
SYNTR_RS04775	COG0835	chemotaxis
SYNTR_RS04780	COG0840	transmembrane signaling receptor activity
SYNTR_RS04785	COG0835	chemotaxis
SYNTR_RS04810	COG1307	EDD domain protein, DegV family
SYNTR_RS04815	COG3464	Transposase
SYNTR_RS04820	COG0668	transmembrane transport
SYNTR_RS04825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SYNTR_RS04850	COG1671	Belongs to the UPF0178 family
SYNTR_RS04870	COG0784	Response regulator, receiver
SYNTR_RS04870	COG2205	protein histidine kinase activity
SYNTR_RS04875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYNTR_RS04885	COG5002	protein histidine kinase activity
SYNTR_RS04890	COG0745	RESPONSE REGULATOR receiver
SYNTR_RS04905	COG1690	Belongs to the RtcB family
SYNTR_RS04915	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SYNTR_RS04925	COG2223	nitrite transmembrane transporter activity
SYNTR_RS04930	COG1242	4 iron, 4 sulfur cluster binding
SYNTR_RS04935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SYNTR_RS04940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYNTR_RS04940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SYNTR_RS04950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYNTR_RS04950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SYNTR_RS04955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SYNTR_RS04960	COG1162	GTPase activity
SYNTR_RS04965	COG0515	serine threonine protein kinase
SYNTR_RS04965	COG2815	serine threonine protein kinase
SYNTR_RS04970	COG0631	protein serine/threonine phosphatase activity
SYNTR_RS04975	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SYNTR_RS04980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SYNTR_RS04980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SYNTR_RS04985	COG2738	Putative neutral zinc metallopeptidase
SYNTR_RS04995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SYNTR_RS05000	COG0242	peptide deformylase activity
SYNTR_RS05005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SYNTR_RS05010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SYNTR_RS05015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SYNTR_RS05020	COG1758	RNA polymerase activity
SYNTR_RS05025	COG0194	GDP metabolic process
SYNTR_RS05030	COG2052	Domain of unknown function (DUF370)
SYNTR_RS05035	COG1561	YicC-like family, N-terminal region
SYNTR_RS05040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYNTR_RS05045	COG3243	poly(R)-hydroxyalkanoic acid synthase
SYNTR_RS05050	COG2030	dehydratase
SYNTR_RS05080	COG0613	PHP domain protein
SYNTR_RS05090	COG2359	stage V sporulation protein S
SYNTR_RS05095	COG1692	metallophosphoesterase
SYNTR_RS05105	COG1418	mRNA catabolic process
SYNTR_RS05110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SYNTR_RS05115	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SYNTR_RS05120	COG1058	Belongs to the CinA family
SYNTR_RS05120	COG1546	Belongs to the CinA family
SYNTR_RS05125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SYNTR_RS05135	COG0427	acetyl-CoA hydrolase
SYNTR_RS05140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SYNTR_RS05145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNTR_RS05155	COG1522	sequence-specific DNA binding
SYNTR_RS05155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SYNTR_RS05165	COG1968	undecaprenyl-diphosphatase activity
SYNTR_RS05175	COG0740	serine-type endopeptidase activity
SYNTR_RS05180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SYNTR_RS05185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SYNTR_RS05190	COG0527	aspartate kinase activity
SYNTR_RS05195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SYNTR_RS05200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SYNTR_RS05210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SYNTR_RS05230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SYNTR_RS05235	COG0284	orotidine-5'-phosphate decarboxylase activity
SYNTR_RS05240	COG0167	dihydroorotate dehydrogenase activity
SYNTR_RS05245	COG0543	2 iron, 2 sulfur cluster binding
SYNTR_RS05250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SYNTR_RS05255	COG0505	Belongs to the CarA family
SYNTR_RS05260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SYNTR_RS05265	COG0540	Belongs to the ATCase OTCase family
SYNTR_RS05270	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SYNTR_RS05275	COG0564	pseudouridine synthase activity
SYNTR_RS05280	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SYNTR_RS05295	COG1151	hydroxylamine reductase activity
SYNTR_RS05310	COG0142	geranyltranstransferase activity
SYNTR_RS05325	COG0438	transferase activity, transferring glycosyl groups
SYNTR_RS05330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SYNTR_RS05340	COG2848	UPF0210 protein
SYNTR_RS05350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SYNTR_RS05355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SYNTR_RS05360	COG3599	regulation of cell shape
SYNTR_RS05365	COG0826	peptidase U32
SYNTR_RS05375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SYNTR_RS05380	COG1799	cell septum assembly
SYNTR_RS05385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SYNTR_RS05395	COG5002	protein histidine kinase activity
SYNTR_RS05400	COG0745	RESPONSE REGULATOR receiver
SYNTR_RS05415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYNTR_RS05420	COG1873	PFAM PRC-barrel domain
SYNTR_RS05465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SYNTR_RS05470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SYNTR_RS05475	COG1193	negative regulation of DNA recombination
SYNTR_RS05485	COG2323	membrane
SYNTR_RS05490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SYNTR_RS05490	COG1796	DNA polymerase
SYNTR_RS05495	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SYNTR_RS05500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SYNTR_RS05505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNTR_RS05505	COG0072	phenylalanine-tRNA ligase activity
SYNTR_RS05505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNTR_RS05505	COG0072	phenylalanine-tRNA ligase activity
SYNTR_RS05510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SYNTR_RS05515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNTR_RS05520	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SYNTR_RS05525	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SYNTR_RS05535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SYNTR_RS05540	COG4399	Belongs to the UPF0754 family
SYNTR_RS05565	COG3963	phosphatidate phosphatase activity
SYNTR_RS05570	COG2720	vancomycin resistance protein
SYNTR_RS05585	COG0006	proline dipeptidase activity
SYNTR_RS05600	COG0835	chemotaxis
SYNTR_RS05605	COG0840	transmembrane signaling receptor activity
SYNTR_RS05640	COG0726	polysaccharide deacetylase
SYNTR_RS05645	COG1322	Protein conserved in bacteria
SYNTR_RS05655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYNTR_RS05690	COG2267	carboxylic ester hydrolase activity
SYNTR_RS05710	COG1074	ATP-dependent DNA helicase activity
SYNTR_RS05730	COG1361	Conserved repeat domain
SYNTR_RS05740	COG1192	Involved in chromosome partitioning
SYNTR_RS05750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SYNTR_RS05760	COG0537	adenosine 5'-monophosphoramidase activity
SYNTR_RS05770	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
SYNTR_RS05775	COG1715	Restriction endonuclease
SYNTR_RS05805	COG0537	adenosine 5'-monophosphoramidase activity
SYNTR_RS05860	COG1337	RAMP superfamily
SYNTR_RS05885	COG1518	maintenance of DNA repeat elements
SYNTR_RS05925	COG3706	GGDEF domain
SYNTR_RS05945	COG0617	tRNA 3'-terminal CCA addition
SYNTR_RS05985	COG1509	lysine 2,3-aminomutase activity
SYNTR_RS05990	COG0456	acetyltransferase
SYNTR_RS06000	COG1533	DNA photolyase activity
SYNTR_RS06005	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SYNTR_RS06025	COG2197	response regulator
SYNTR_RS06060	COG0083	homoserine kinase activity
SYNTR_RS06065	COG0460	homoserine dehydrogenase
SYNTR_RS06070	COG4492	Belongs to the UPF0735 family
SYNTR_RS06075	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SYNTR_RS06080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SYNTR_RS06085	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SYNTR_RS06130	COG1304	FMN binding
SYNTR_RS06145	COG0539	negative regulation of cytoplasmic translation
SYNTR_RS06145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SYNTR_RS06190	COG2274	protein secretion by the type I secretion system
SYNTR_RS06195	COG2274	protein secretion by the type I secretion system
SYNTR_RS06220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SYNTR_RS06225	COG0287	Prephenate dehydrogenase
SYNTR_RS06230	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SYNTR_RS06240	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SYNTR_RS06245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SYNTR_RS06270	COG1691	(AIR) carboxylase
SYNTR_RS06275	COG0137	argininosuccinate synthase activity
SYNTR_RS06290	COG0674	pyruvate-flavodoxin oxidoreductase activity
SYNTR_RS06305	COG1418	mRNA catabolic process
SYNTR_RS06305	COG2433	Pfam Transposase IS66
SYNTR_RS06315	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SYNTR_RS06320	COG1187	pseudouridine synthase activity
SYNTR_RS06335	COG0302	gtp cyclohydrolase
SYNTR_RS06340	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SYNTR_RS06370	COG3118	belongs to the thioredoxin family
SYNTR_RS06385	COG3404	Formiminotransferase-cyclodeaminase
SYNTR_RS06395	COG0700	Nucleoside recognition
SYNTR_RS06400	COG2715	membrane protein required for spore maturation
SYNTR_RS06405	COG3874	Sporulation protein YtfJ
SYNTR_RS06420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SYNTR_RS06430	COG1994	Peptidase M50
SYNTR_RS06435	COG0617	tRNA 3'-terminal CCA addition
SYNTR_RS06435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SYNTR_RS06435	COG3620	sequence-specific DNA binding
SYNTR_RS06450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYNTR_RS06455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SYNTR_RS06465	COG1862	Preprotein translocase
SYNTR_RS06470	COG0343	queuine tRNA-ribosyltransferase activity
SYNTR_RS06475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SYNTR_RS06485	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SYNTR_RS06490	COG2255	four-way junction helicase activity
SYNTR_RS06495	COG0632	four-way junction helicase activity
SYNTR_RS06500	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SYNTR_RS06515	COG0217	transcriptional regulatory protein
SYNTR_RS06520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SYNTR_RS06525	COG1410	methionine synthase
SYNTR_RS06525	COG0646	methionine synthase
SYNTR_RS06530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SYNTR_RS06545	COG0606	chelatase, subunit chli
SYNTR_RS06570	COG1174	glycine betaine transport
SYNTR_RS06590	COG1174	glycine betaine transport
SYNTR_RS06605	COG0438	transferase activity, transferring glycosyl groups
SYNTR_RS06625	COG2217	Heavy metal translocating P-type atpase
SYNTR_RS06640	COG1725	Transcriptional regulator
SYNTR_RS06645	COG1131	(ABC) transporter
SYNTR_RS06655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SYNTR_RS06660	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SYNTR_RS06665	COG0792	nuclease activity
SYNTR_RS06670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SYNTR_RS06680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SYNTR_RS06705	COG0335	large ribosomal subunit rRNA binding
SYNTR_RS06710	COG4752	Belongs to the RNA methyltransferase TrmD family
SYNTR_RS06715	COG0336	Belongs to the RNA methyltransferase TrmD family
SYNTR_RS06720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SYNTR_RS06725	COG1837	Belongs to the UPF0109 family
SYNTR_RS06730	COG0228	four-way junction DNA binding
SYNTR_RS06735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SYNTR_RS06740	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SYNTR_RS06745	COG1307	EDD domain protein, DegV family
SYNTR_RS06775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SYNTR_RS06780	COG0358	DNA primase activity
SYNTR_RS06795	COG3409	Peptidoglycan-binding domain 1 protein
SYNTR_RS06795	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYNTR_RS06800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SYNTR_RS06800	COG0574	Belongs to the PEP-utilizing enzyme family
SYNTR_RS06805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SYNTR_RS06810	COG0517	IMP dehydrogenase activity
SYNTR_RS06815	COG0751	glycine-tRNA ligase activity
SYNTR_RS06820	COG0752	glycyl-tRNA synthetase alpha subunit
SYNTR_RS06825	COG1381	Involved in DNA repair and RecF pathway recombination
SYNTR_RS06840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SYNTR_RS06845	COG0295	cytidine deaminase activity
SYNTR_RS06850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SYNTR_RS06855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SYNTR_RS06860	COG1480	7TM receptor with intracellular HD hydrolase
SYNTR_RS06865	COG1702	phosphate starvation-inducible protein PhoH
SYNTR_RS06880	COG1376	ErfK ybiS ycfS ynhG family protein
SYNTR_RS06885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SYNTR_RS06890	COG0537	adenosine 5'-monophosphoramidase activity
SYNTR_RS06895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SYNTR_RS06900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SYNTR_RS06905	COG2264	protein methyltransferase activity
SYNTR_RS06910	COG0484	heat shock protein binding
SYNTR_RS06915	COG0443	Heat shock 70 kDa protein
SYNTR_RS06920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SYNTR_RS06925	COG1420	regulation of RNA biosynthetic process
SYNTR_RS06930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SYNTR_RS06935	COG0481	GTPase activity
SYNTR_RS06950	COG0268	Binds directly to 16S ribosomal RNA
SYNTR_RS06960	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SYNTR_RS06965	COG2703	oxygen carrier activity
SYNTR_RS06975	COG0658	competence protein
SYNTR_RS06975	COG2333	competence protein COMEC
SYNTR_RS06995	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SYNTR_RS07015	COG1596	polysaccharide export
SYNTR_RS07015	COG1555	photosystem II stabilization
SYNTR_RS07025	COG3464	Transposase
SYNTR_RS07035	COG0495	leucyl-tRNA aminoacylation
SYNTR_RS07045	COG0799	negative regulation of ribosome biogenesis
SYNTR_RS07050	COG1713	HD superfamily hydrolase involved in NAD metabolism
SYNTR_RS07065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SYNTR_RS07075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SYNTR_RS07085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SYNTR_RS07090	COG2868	ribosomal protein
SYNTR_RS07095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SYNTR_RS07125	COG0772	Belongs to the SEDS family
SYNTR_RS07130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SYNTR_RS07135	COG2894	cell division
SYNTR_RS07140	COG0850	regulation of cytokinetic process
SYNTR_RS07160	COG1077	Cell shape determining protein MreB Mrl
SYNTR_RS07165	COG2003	Belongs to the UPF0758 family
SYNTR_RS07170	COG0424	maF-like protein
SYNTR_RS07180	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SYNTR_RS07185	COG0306	phosphate transporter
SYNTR_RS07190	COG1392	Phosphate transport regulator
SYNTR_RS07195	COG0285	dihydrofolate synthase activity
SYNTR_RS07200	COG0525	valine-tRNA ligase activity
SYNTR_RS07205	COG2302	S4 RNA-binding domain
SYNTR_RS07215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SYNTR_RS07220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SYNTR_RS07225	COG1067	ATP-dependent peptidase activity
SYNTR_RS07225	COG0470	DNA polymerase III
SYNTR_RS07235	COG0740	serine-type endopeptidase activity
SYNTR_RS07240	COG0544	peptidyl-prolyl cis-trans isomerase activity
SYNTR_RS07295	COG0840	transmembrane signaling receptor activity
SYNTR_RS07300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYNTR_RS07305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SYNTR_RS07310	COG4145	pantothenate transmembrane transporter activity
SYNTR_RS07315	COG0640	Transcriptional regulator
SYNTR_RS07340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SYNTR_RS07345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SYNTR_RS07360	COG2340	Cysteine-rich secretory protein family
SYNTR_RS07365	COG3738	Protein conserved in bacteria
SYNTR_RS07380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYNTR_RS07385	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SYNTR_RS07390	COG0159	tryptophan synthase activity
SYNTR_RS07395	COG0133	tryptophan synthase activity
SYNTR_RS07400	COG0135	phosphoribosylanthranilate isomerase activity
SYNTR_RS07405	COG0134	indole-3-glycerol-phosphate synthase activity
SYNTR_RS07410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SYNTR_RS07415	COG0512	Glutamine amidotransferase of anthranilate synthase
SYNTR_RS07420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYNTR_RS07425	COG2414	aldehyde ferredoxin oxidoreductase
SYNTR_RS07455	COG0427	acetyl-CoA hydrolase
SYNTR_RS07460	COG0183	Belongs to the thiolase family
SYNTR_RS07470	COG1217	gtp-binding protein TYPA
SYNTR_RS07505	COG2197	response regulator
SYNTR_RS07535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SYNTR_RS07545	COG0534	Mate efflux family protein
SYNTR_RS07550	COG0116	Belongs to the methyltransferase superfamily
SYNTR_RS07555	COG0662	Cupin 2, conserved barrel domain protein
SYNTR_RS07555	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SYNTR_RS07565	COG0438	transferase activity, transferring glycosyl groups
SYNTR_RS07575	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SYNTR_RS07580	COG1164	Oligoendopeptidase f
SYNTR_RS07585	COG2816	NAD+ diphosphatase activity
SYNTR_RS07590	COG0372	Belongs to the citrate synthase family
SYNTR_RS07610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SYNTR_RS07615	COG1193	negative regulation of DNA recombination
SYNTR_RS07620	COG1832	CoA-binding protein
SYNTR_RS07630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SYNTR_RS07635	COG0488	(ABC) transporter
SYNTR_RS07670	COG1136	(ABC) transporter
SYNTR_RS07680	COG0330	HflC and HflK could
SYNTR_RS07690	COG1278	Cold shock
SYNTR_RS07695	COG1510	regulation of RNA biosynthetic process
SYNTR_RS07705	COG1335	isochorismatase
SYNTR_RS07720	COG0463	Glycosyl transferase, family 2
SYNTR_RS07720	COG0457	Tetratricopeptide repeat
SYNTR_RS07760	COG1086	Polysaccharide biosynthesis protein
SYNTR_RS07780	COG1028	Short-chain dehydrogenase reductase Sdr
SYNTR_RS07785	COG1960	acyl-CoA dehydrogenase activity
SYNTR_RS07815	COG2113	Glycine betaine
SYNTR_RS07825	COG0747	negative chemotaxis
SYNTR_RS07835	COG0237	dephospho-CoA kinase activity
SYNTR_RS07840	COG1971	Probably functions as a manganese efflux pump
SYNTR_RS07845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SYNTR_RS07880	COG1024	Enoyl-CoA hydratase
SYNTR_RS07890	COG0205	6-phosphofructokinase activity
SYNTR_RS07905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SYNTR_RS07935	COG0730	response to heat
SYNTR_RS07940	COG1012	belongs to the aldehyde dehydrogenase family
SYNTR_RS07960	COG1160	GTP binding
SYNTR_RS07970	COG5577	PFAM Coat F domain
SYNTR_RS07995	COG1342	Belongs to the UPF0251 family
SYNTR_RS08020	COG2827	Endonuclease containing a URI domain
SYNTR_RS08025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SYNTR_RS08030	COG1404	Belongs to the peptidase S8 family
SYNTR_RS08035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SYNTR_RS08040	COG2894	cell division
SYNTR_RS08045	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
SYNTR_RS08050	COG0850	regulation of cytokinetic process
SYNTR_RS08065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SYNTR_RS08075	COG2323	membrane
SYNTR_RS08085	COG2873	o-acetylhomoserine
SYNTR_RS08090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SYNTR_RS08110	COG1360	Flagellar Motor Protein
SYNTR_RS08115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SYNTR_RS08120	COG1283	sodium-dependent phosphate transmembrane transporter activity
SYNTR_RS08125	COG1595	DNA-templated transcription, initiation
SYNTR_RS08145	COG0778	Nitroreductase
SYNTR_RS08155	COG1979	alcohol dehydrogenase
SYNTR_RS08165	COG0427	acetyl-CoA hydrolase
SYNTR_RS08185	COG2099	Precorrin-6x reductase
SYNTR_RS08220	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SYNTR_RS08235	COG1492	cobalamin metabolic process
SYNTR_RS08240	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SYNTR_RS08250	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SYNTR_RS08255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SYNTR_RS08260	COG0406	alpha-ribazole phosphatase activity
SYNTR_RS08265	COG0310	cobalt ion transport
SYNTR_RS08270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SYNTR_RS08275	COG1122	ATPase activity
SYNTR_RS08280	COG1122	ATPase activity
SYNTR_RS08290	COG4175	Glycine betaine
SYNTR_RS08290	COG3448	diguanylate cyclase activity
SYNTR_RS08295	COG4176	ABC-type proline glycine betaine transport system permease component
SYNTR_RS08335	COG1301	dicarboxylic acid transport
SYNTR_RS08340	COG2909	trisaccharide binding
SYNTR_RS08430	COG2113	Glycine betaine
SYNTR_RS08445	COG0006	proline dipeptidase activity
SYNTR_RS08450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SYNTR_RS08455	COG1396	sequence-specific DNA binding
SYNTR_RS08460	COG3706	GGDEF domain
SYNTR_RS08500	COG0582	viral genome integration into host DNA
SYNTR_RS08510	COG4974	Belongs to the 'phage' integrase family
SYNTR_RS08525	COG3266	domain, Protein
SYNTR_RS08525	COG1361	Conserved repeat domain
SYNTR_RS08525	COG2911	Protein conserved in bacteria
SYNTR_RS08535	COG2909	trisaccharide binding
SYNTR_RS08540	COG3973	AAA domain
SYNTR_RS08545	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SYNTR_RS08555	COG0488	(ABC) transporter
SYNTR_RS08620	COG0863	Belongs to the N(4) N(6)-methyltransferase family
SYNTR_RS08635	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SYNTR_RS08645	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SYNTR_RS08665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SYNTR_RS08670	COG0557	exoribonuclease II activity
SYNTR_RS08685	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SYNTR_RS08690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SYNTR_RS08695	COG0148	phosphopyruvate hydratase activity
SYNTR_RS08705	COG0149	triose-phosphate isomerase activity
SYNTR_RS08710	COG0126	phosphoglycerate kinase activity
SYNTR_RS08725	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SYNTR_RS08730	COG1481	regulation of sporulation
SYNTR_RS08735	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SYNTR_RS08740	COG1660	Displays ATPase and GTPase activities
SYNTR_RS08745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SYNTR_RS08750	COG0601	transmembrane transport
SYNTR_RS08755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SYNTR_RS08760	COG0444	Belongs to the ABC transporter superfamily
SYNTR_RS08765	COG4608	Belongs to the ABC transporter superfamily
SYNTR_RS08770	COG0747	negative chemotaxis
SYNTR_RS08785	COG2222	sugar isomerase
SYNTR_RS08790	COG1940	carbohydrate kinase activity
SYNTR_RS08795	COG0561	phosphatase activity
SYNTR_RS08800	COG1950	PFAM Membrane protein of
SYNTR_RS08805	COG0322	excinuclease ABC activity
SYNTR_RS08815	COG0556	nucleotide-excision repair
SYNTR_RS08825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNTR_RS08830	COG0793	Belongs to the peptidase S41A family
SYNTR_RS08835	COG0739	heme binding
SYNTR_RS08840	COG2177	Part of the ABC transporter FtsEX involved in
SYNTR_RS08845	COG2884	Cell division ATP-binding protein ftsE
SYNTR_RS08850	COG3958	Transketolase
SYNTR_RS08855	COG3959	Transketolase, thiamine diphosphate binding domain
SYNTR_RS08860	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SYNTR_RS08865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SYNTR_RS08870	COG0573	inorganic phosphate transmembrane transporter activity
SYNTR_RS08880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SYNTR_RS08885	COG0653	protein targeting
SYNTR_RS08910	COG1516	flagellar protein fliS
SYNTR_RS08915	COG1334	flagellar protein FlaG
SYNTR_RS08950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SYNTR_RS08980	COG1192	Involved in chromosome partitioning
SYNTR_RS09055	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SYNTR_RS09060	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SYNTR_RS09065	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SYNTR_RS09075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SYNTR_RS09080	COG4786	Flagellar basal body rod
SYNTR_RS09080	COG1256	bacterial-type flagellum assembly
SYNTR_RS09105	COG1040	competence protein
SYNTR_RS09125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYNTR_RS09130	COG2323	membrane
SYNTR_RS09135	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SYNTR_RS09150	COG1309	transcriptional regulator
SYNTR_RS09180	COG0793	Belongs to the peptidase S41A family
SYNTR_RS09205	COG5337	Spore coat protein CotH
SYNTR_RS09230	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
SYNTR_RS09235	COG2337	Toxic component of a toxin-antitoxin (TA) module
SYNTR_RS09240	COG2336	PFAM SpoVT AbrB
SYNTR_RS09245	COG1136	(ABC) transporter
SYNTR_RS09245	COG0577	efflux transmembrane transporter activity
SYNTR_RS09255	COG1136	(ABC) transporter
SYNTR_RS09270	COG3464	Transposase
SYNTR_RS09280	COG2373	Large extracellular alpha-helical protein
SYNTR_RS09300	COG2373	Large extracellular alpha-helical protein
SYNTR_RS09310	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYNTR_RS09310	COG2247	cell wall binding repeat
SYNTR_RS09330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SYNTR_RS09335	COG0728	peptidoglycan biosynthetic process
SYNTR_RS09340	COG1316	TRANSCRIPTIONal
SYNTR_RS09345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SYNTR_RS09370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SYNTR_RS09375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SYNTR_RS09395	COG3402	PFAM membrane-flanked domain
SYNTR_RS09400	COG3428	Bacterial PH domain
SYNTR_RS09405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SYNTR_RS09410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SYNTR_RS09415	COG3191	aminopeptidase activity
SYNTR_RS09430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SYNTR_RS09435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SYNTR_RS09440	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SYNTR_RS09445	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SYNTR_RS09450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SYNTR_RS09470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SYNTR_RS09475	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SYNTR_RS09485	COG0037	tRNA processing
SYNTR_RS09490	COG2208	phosphoserine phosphatase activity
SYNTR_RS09495	COG2116	formate transmembrane transporter activity
SYNTR_RS09505	COG0248	Ppx GppA phosphatase
SYNTR_RS09510	COG1098	S1 RNA binding domain
SYNTR_RS09515	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SYNTR_RS09535	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SYNTR_RS09545	COG3956	TIGRFAM MazG family protein
SYNTR_RS09550	COG2244	polysaccharide biosynthetic process
SYNTR_RS09555	COG2002	toxin-antitoxin pair type II binding
SYNTR_RS09560	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SYNTR_RS09565	COG0697	spore germination
SYNTR_RS09590	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SYNTR_RS09600	COG0193	aminoacyl-tRNA hydrolase activity
SYNTR_RS09605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SYNTR_RS09610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SYNTR_RS09615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SYNTR_RS09625	COG1802	Transcriptional regulator
SYNTR_RS09630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SYNTR_RS09640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SYNTR_RS09645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SYNTR_RS09650	COG0512	Glutamine amidotransferase of anthranilate synthase
SYNTR_RS09670	COG1063	alcohol dehydrogenase
SYNTR_RS09685	COG1876	peptidase activity
SYNTR_RS09695	COG1342	Belongs to the UPF0251 family
SYNTR_RS09710	COG1752	Esterase of the alpha-beta hydrolase superfamily
SYNTR_RS09730	COG0438	transferase activity, transferring glycosyl groups
SYNTR_RS09750	COG4466	Protein conserved in bacteria
SYNTR_RS09755	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
SYNTR_RS09760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SYNTR_RS09770	COG3584	3D domain protein
SYNTR_RS09770	COG3583	domain protein
SYNTR_RS09775	COG0084	hydrolase, TatD family'
SYNTR_RS09780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNTR_RS09780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SYNTR_RS09785	COG2002	toxin-antitoxin pair type II binding
SYNTR_RS09790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SYNTR_RS09795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SYNTR_RS09805	COG1774	PSP1 C-terminal conserved region
SYNTR_RS09810	COG0470	DNA polymerase III
SYNTR_RS09825	COG1982	Orn Lys Arg decarboxylase major
SYNTR_RS09830	COG1597	lipid kinase activity
SYNTR_RS09900	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SYNTR_RS09905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SYNTR_RS09910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SYNTR_RS09950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SYNTR_RS09955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SYNTR_RS09965	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SYNTR_RS09970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SYNTR_RS09975	COG0187	DNA topoisomerase II activity
SYNTR_RS09985	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SYNTR_RS09990	COG0592	DNA-directed DNA polymerase activity
SYNTR_RS09995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SYNTR_RS10000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SYNTR_RS10005	COG0594	ribonuclease P activity
SYNTR_RS10010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SYNTR_RS10015	COG0706	membrane insertase activity
SYNTR_RS10020	COG1847	R3H domain protein
SYNTR_RS10025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SYNTR_RS10030	COG0445	tRNA wobble uridine modification
SYNTR_RS10035	COG0357	Ribosomal RNA small subunit methyltransferase G
SYNTR_RS10045	COG1192	Involved in chromosome partitioning
SYNTR_RS10050	COG1475	DNA binding
SYNTR_RS10070	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SYNTR_RS10075	COG0739	heme binding
SYNTR_RS10075	COG0741	lytic transglycosylase activity
SYNTR_RS10075	COG1196	nuclear chromosome segregation
SYNTR_RS10095	COG3949	Membrane
SYNTR_RS10100	COG1921	L-seryl-tRNASec selenium transferase activity
SYNTR_RS10120	COG1924	4 iron, 4 sulfur cluster binding
SYNTR_RS10145	COG1362	aminopeptidase activity
SYNTR_RS10165	COG0360	Binds together with S18 to 16S ribosomal RNA
SYNTR_RS10170	COG0629	single-stranded DNA binding
SYNTR_RS10175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SYNTR_RS10190	COG0359	binds to the 23S rRNA
SYNTR_RS10195	COG1067	ATP-dependent peptidase activity
SYNTR_RS10195	COG0470	DNA polymerase III
SYNTR_RS10200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SYNTR_RS10220	COG0739	heme binding
SYNTR_RS10235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYNTR_RS10240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SYNTR_RS10245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SYNTR_RS10255	COG2814	Major facilitator Superfamily
SYNTR_RS10275	COG0017	Asparaginyl-tRNA synthetase
SYNTR_RS10290	COG0513	Belongs to the DEAD box helicase family
SYNTR_RS10295	COG0179	Fumarylacetoacetate (FAA) hydrolase
SYNTR_RS10315	COG1361	Conserved repeat domain
SYNTR_RS10320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SYNTR_RS10330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SYNTR_RS10335	COG2022	thiamine diphosphate biosynthetic process
SYNTR_RS10340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SYNTR_RS10345	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SYNTR_RS10375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SYNTR_RS10390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SYNTR_RS10395	COG2210	Belongs to the sulfur carrier protein TusA family
SYNTR_RS10430	COG0018	arginyl-trna synthetase
SYNTR_RS10440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SYNTR_RS10445	COG0504	CTP synthase activity
SYNTR_RS10450	COG2348	transferase activity, transferring amino-acyl groups
SYNTR_RS10460	COG0616	signal peptide processing
SYNTR_RS10470	COG2204	response regulator
SYNTR_RS10475	COG0191	fructose-bisphosphate aldolase activity
SYNTR_RS10480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SYNTR_RS10485	COG1494	fructose-1,6-bisphosphatase
SYNTR_RS10490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SYNTR_RS10495	COG0739	heme binding
SYNTR_RS10505	COG3481	metal-dependent phosphohydrolase, HD sub domain
SYNTR_RS10510	COG0393	Putative heavy-metal-binding
SYNTR_RS10520	COG1131	(ABC) transporter
SYNTR_RS10525	COG1725	Transcriptional regulator
SYNTR_RS10530	COG0254	rRNA binding
SYNTR_RS10535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SYNTR_RS10540	COG2890	protein-(glutamine-N5) methyltransferase activity
SYNTR_RS10545	COG0009	L-threonylcarbamoyladenylate synthase
SYNTR_RS10550	COG1971	Probably functions as a manganese efflux pump
SYNTR_RS10555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SYNTR_RS10560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SYNTR_RS10580	COG0356	it plays a direct role in the translocation of protons across the membrane
SYNTR_RS10585	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYNTR_RS10590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SYNTR_RS10595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SYNTR_RS10600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SYNTR_RS10610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SYNTR_RS10615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SYNTR_RS10635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SYNTR_RS10640	COG2385	sporulation resulting in formation of a cellular spore
SYNTR_RS10645	COG1609	Transcriptional regulator
SYNTR_RS10650	COG1077	Cell shape determining protein MreB Mrl
SYNTR_RS10655	COG4786	Flagellar basal body rod
SYNTR_RS10665	COG0849	cell division
SYNTR_RS10680	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SYNTR_RS10685	COG0542	response to heat
SYNTR_RS10690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SYNTR_RS10695	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SYNTR_RS10705	COG4956	integral membrane protein (PIN domain superfamily)
SYNTR_RS10710	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SYNTR_RS10720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SYNTR_RS10725	COG1045	serine acetyltransferase
SYNTR_RS10730	COG0215	cysteine-tRNA ligase activity
SYNTR_RS10745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SYNTR_RS10785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SYNTR_RS10790	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SYNTR_RS10800	COG0250	Participates in transcription elongation, termination and antitermination
SYNTR_RS10805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SYNTR_RS10810	COG0081	regulation of translation
SYNTR_RS10815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SYNTR_RS10820	COG0222	ribosome binding
SYNTR_RS10830	COG0085	RNA polymerase activity
SYNTR_RS10835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SYNTR_RS10840	COG1358	cellular component organization or biogenesis
SYNTR_RS10845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SYNTR_RS10850	COG0049	tRNA binding
SYNTR_RS10855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SYNTR_RS10860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SYNTR_RS10865	COG0051	transcription antitermination factor activity, RNA binding
SYNTR_RS10870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SYNTR_RS10875	COG0088	Forms part of the polypeptide exit tunnel
SYNTR_RS10880	COG0089	rRNA binding
SYNTR_RS10885	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SYNTR_RS10890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SYNTR_RS10895	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SYNTR_RS10900	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SYNTR_RS10905	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SYNTR_RS10915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SYNTR_RS10920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SYNTR_RS10925	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SYNTR_RS10930	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SYNTR_RS10935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SYNTR_RS10940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SYNTR_RS10945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SYNTR_RS10950	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SYNTR_RS10955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SYNTR_RS10960	COG1841	ribosomal large subunit assembly
SYNTR_RS10965	COG0200	Binds to the 23S rRNA
SYNTR_RS10970	COG0201	protein transport
SYNTR_RS10975	COG0563	adenylate kinase activity
SYNTR_RS10990	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SYNTR_RS10995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SYNTR_RS11000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SYNTR_RS11005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SYNTR_RS11010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SYNTR_RS11015	COG0202	RNA polymerase activity
SYNTR_RS11020	COG0203	ribosomal protein L17
SYNTR_RS11025	COG1122	ATPase activity
SYNTR_RS11035	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SYNTR_RS11040	COG0101	tRNA pseudouridine synthase activity
SYNTR_RS11045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SYNTR_RS11050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SYNTR_RS11055	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYNTR_RS11060	COG2078	PFAM AMMECR1 domain protein
SYNTR_RS11060	COG3885	ferrous iron binding
SYNTR_RS11070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SYNTR_RS11075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SYNTR_RS11080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SYNTR_RS11085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SYNTR_RS11090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SYNTR_RS11095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SYNTR_RS11100	COG1328	CTP reductase activity
SYNTR_RS11100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SYNTR_RS11115	COG0367	asparagine synthase
SYNTR_RS11120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SYNTR_RS11125	COG5002	protein histidine kinase activity
SYNTR_RS11135	COG0514	ATP-dependent DNA helicase (RecQ)
SYNTR_RS11140	COG3584	3D domain protein
SYNTR_RS11140	COG1388	LysM domain
SYNTR_RS11150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SYNTR_RS11160	COG1968	undecaprenyl-diphosphatase activity
SYNTR_RS11165	COG0860	N-Acetylmuramoyl-L-alanine amidase
SYNTR_RS11185	COG0129	dihydroxy-acid dehydratase activity
SYNTR_RS11190	COG0028	Belongs to the TPP enzyme family
SYNTR_RS11195	COG0440	acetolactate synthase activity
SYNTR_RS11200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SYNTR_RS11205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYNTR_RS11210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SYNTR_RS11215	COG0066	3-isopropylmalate dehydratase activity
SYNTR_RS11220	COG0473	3-isopropylmalate dehydrogenase activity
SYNTR_RS11225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SYNTR_RS11245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SYNTR_RS11255	COG2081	HI0933 family
SYNTR_RS11260	COG0714	Associated with various cellular activities
SYNTR_RS11275	COG2766	serine protein kinase
SYNTR_RS11280	COG2718	Belongs to the UPF0229 family
SYNTR_RS11285	COG2719	SpoVR family
SYNTR_RS11315	COG1011	Hydrolase
SYNTR_RS11325	COG0328	RNA-DNA hybrid ribonuclease activity
SYNTR_RS11330	COG0110	maltose O-acetyltransferase activity
SYNTR_RS11340	COG2385	sporulation resulting in formation of a cellular spore
SYNTR_RS11345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SYNTR_RS11360	COG2221	Nitrite and sulphite reductase 4Fe-4S
SYNTR_RS11370	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SYNTR_RS11380	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SYNTR_RS11385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SYNTR_RS11405	COG3290	protein histidine kinase activity
SYNTR_RS11420	COG3279	Response regulator of the LytR AlgR family
SYNTR_RS11455	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SYNTR_RS11470	COG0798	PFAM Bile acid sodium symporter
SYNTR_RS11480	COG2226	methyltransferase