locus-tag	class	description
THSYN_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THSYN_RS00010	COG0592	DNA-directed DNA polymerase activity
THSYN_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THSYN_RS00035	COG0751	glycine-tRNA ligase activity
THSYN_RS00045	COG0174	glutamine synthetase
THSYN_RS00055	COG3852	Histidine kinase
THSYN_RS00060	COG2204	response regulator
THSYN_RS00075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
THSYN_RS00080	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THSYN_RS00105	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THSYN_RS00115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THSYN_RS00120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
THSYN_RS00125	COG1054	Belongs to the UPF0176 family
THSYN_RS00135	COG0793	Belongs to the peptidase S41A family
THSYN_RS00140	COG0693	protein deglycase activity
THSYN_RS00145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THSYN_RS00150	COG1086	Polysaccharide biosynthesis protein
THSYN_RS00155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THSYN_RS00160	COG1459	type II secretion system
THSYN_RS00200	COG1355	regulation of microtubule-based process
THSYN_RS00210	COG4536	flavin adenine dinucleotide binding
THSYN_RS00215	COG0671	phosphoesterase, PA-phosphatase related
THSYN_RS00220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THSYN_RS00225	COG0463	Glycosyl transferase, family 2
THSYN_RS00255	COG0137	argininosuccinate synthase activity
THSYN_RS00275	COG2133	pyrroloquinoline quinone binding
THSYN_RS00285	COG3842	ATPase activity
THSYN_RS00290	COG3833	ABC-type maltose transport systems, permease component
THSYN_RS00295	COG1175	transmembrane transport
THSYN_RS00300	COG2182	Extracellular solute-binding protein
THSYN_RS00320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THSYN_RS00330	COG0488	(ABC) transporter
THSYN_RS00335	COG0606	chelatase, subunit chli
THSYN_RS00340	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
THSYN_RS00345	COG2960	long-chain fatty acid transporting porin activity
THSYN_RS00355	COG0347	Belongs to the P(II) protein family
THSYN_RS00360	COG0004	ammonium transporteR
THSYN_RS00375	COG1802	Transcriptional regulator
THSYN_RS00410	COG0531	amino acid
THSYN_RS00415	COG0586	Pfam SNARE associated Golgi protein
THSYN_RS00440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THSYN_RS00460	COG0356	it plays a direct role in the translocation of protons across the membrane
THSYN_RS00470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THSYN_RS00475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THSYN_RS00485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THSYN_RS00510	COG0569	domain protein
THSYN_RS00545	COG0741	lytic transglycosylase activity
THSYN_RS00605	COG0515	serine threonine protein kinase
THSYN_RS00605	COG2815	serine threonine protein kinase
THSYN_RS00650	COG0784	Response regulator, receiver
THSYN_RS00650	COG2205	protein histidine kinase activity
THSYN_RS00650	COG5002	protein histidine kinase activity
THSYN_RS00655	COG0653	protein targeting
THSYN_RS00675	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THSYN_RS00790	COG0517	IMP dehydrogenase activity
THSYN_RS00795	COG4974	Belongs to the 'phage' integrase family
THSYN_RS00815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THSYN_RS00820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THSYN_RS00840	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS00845	COG0247	lactate metabolic process
THSYN_RS00895	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THSYN_RS00900	COG0045	succinate-CoA ligase (ADP-forming) activity
THSYN_RS00915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THSYN_RS00915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THSYN_RS00950	COG1061	Type III restriction enzyme res subunit
THSYN_RS00970	COG2084	Dehydrogenase
THSYN_RS00975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
THSYN_RS00980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THSYN_RS00985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THSYN_RS01010	COG0006	proline dipeptidase activity
THSYN_RS01020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS01060	COG0602	queuosine metabolic process
THSYN_RS01065	COG0720	synthase
THSYN_RS01090	COG2176	DNA-directed DNA polymerase activity
THSYN_RS01110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THSYN_RS01115	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
THSYN_RS01150	COG2995	paraquat-inducible protein a
THSYN_RS01155	COG3008	intermembrane lipid transfer
THSYN_RS01175	COG0508	dehydrogenase complex catalyzes the overall conversion of
THSYN_RS01220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THSYN_RS01230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THSYN_RS01240	COG2244	polysaccharide biosynthetic process
THSYN_RS01245	COG4974	Belongs to the 'phage' integrase family
THSYN_RS01250	COG0517	IMP dehydrogenase activity
THSYN_RS01265	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THSYN_RS01280	COG2944	sequence-specific DNA binding
THSYN_RS01400	COG2204	response regulator
THSYN_RS01420	COG2835	tetraacyldisaccharide 4'-kinase activity
THSYN_RS01425	COG0009	L-threonylcarbamoyladenylate synthase
THSYN_RS01430	COG1653	transport
THSYN_RS01435	COG0784	Response regulator, receiver
THSYN_RS01435	COG2205	protein histidine kinase activity
THSYN_RS01435	COG2198	Histidine kinase
THSYN_RS01440	COG2198	Histidine kinase
THSYN_RS01440	COG0784	Response regulator, receiver
THSYN_RS01440	COG2205	protein histidine kinase activity
THSYN_RS01460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
THSYN_RS01480	COG1253	flavin adenine dinucleotide binding
THSYN_RS01485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THSYN_RS01495	COG0277	FAD linked oxidase domain protein
THSYN_RS01500	COG2823	Periplasmic or secreted lipoprotein
THSYN_RS01505	COG0792	nuclease activity
THSYN_RS01510	COG3107	peptidoglycan biosynthetic process
THSYN_RS01525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THSYN_RS01535	COG2226	methyltransferase
THSYN_RS01555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THSYN_RS01570	COG4804	nuclease activity
THSYN_RS01575	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THSYN_RS01590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THSYN_RS01605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
THSYN_RS01610	COG1902	pentaerythritol trinitrate reductase activity
THSYN_RS01680	COG2264	protein methyltransferase activity
THSYN_RS01685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THSYN_RS01695	COG0138	bifunctional purine biosynthesis protein purh
THSYN_RS01700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THSYN_RS01705	COG0151	Belongs to the GarS family
THSYN_RS01710	COG0167	dihydroorotate dehydrogenase activity
THSYN_RS01715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS01715	COG0515	serine threonine protein kinase
THSYN_RS01730	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
THSYN_RS01740	COG0277	FAD linked oxidase domain protein
THSYN_RS01745	COG0247	lactate metabolic process
THSYN_RS01865	COG2022	thiamine diphosphate biosynthetic process
THSYN_RS01865	COG2104	thiamine diphosphate biosynthetic process
THSYN_RS01875	COG1022	Amp-dependent synthetase and ligase
THSYN_RS01890	COG1194	a g-specific adenine glycosylase
THSYN_RS01895	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
THSYN_RS01905	COG3023	N-Acetylmuramoyl-L-alanine amidase
THSYN_RS01950	COG2204	response regulator
THSYN_RS01955	COG0784	Response regulator, receiver
THSYN_RS01955	COG2205	protein histidine kinase activity
THSYN_RS01955	COG2198	Histidine kinase
THSYN_RS01960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THSYN_RS01965	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
THSYN_RS01975	COG5001	Diguanylate cyclase
THSYN_RS01985	COG5433	transposase activity
THSYN_RS02015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THSYN_RS02030	COG1660	Displays ATPase and GTPase activities
THSYN_RS02045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
THSYN_RS02065	COG1137	ATPase activity
THSYN_RS02080	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THSYN_RS02100	COG1127	ABC transporter
THSYN_RS02105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THSYN_RS02110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THSYN_RS02125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THSYN_RS02130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THSYN_RS02205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THSYN_RS02225	COG1879	ABC-type sugar transport system periplasmic component
THSYN_RS02240	COG1196	nuclear chromosome segregation
THSYN_RS02250	COG4581	dead DEAH box helicase
THSYN_RS02275	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
THSYN_RS02285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THSYN_RS02290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
THSYN_RS02295	COG0205	6-phosphofructokinase activity
THSYN_RS02300	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THSYN_RS02305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THSYN_RS02310	COG0315	cyclic pyranopterin monophosphate synthase activity
THSYN_RS02315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THSYN_RS02350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THSYN_RS02360	COG2205	protein histidine kinase activity
THSYN_RS02365	COG0745	RESPONSE REGULATOR receiver
THSYN_RS02380	COG0517	IMP dehydrogenase activity
THSYN_RS02385	COG4974	Belongs to the 'phage' integrase family
THSYN_RS02415	COG2814	Major facilitator Superfamily
THSYN_RS02420	COG0629	single-stranded DNA binding
THSYN_RS02425	COG2192	nodulation
THSYN_RS02430	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS02445	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS02450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THSYN_RS02465	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS02470	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS02490	COG1450	Type ii and iii secretion system protein
THSYN_RS02520	COG2165	general secretion pathway protein
THSYN_RS02535	COG2974	May be involved in recombination
THSYN_RS02540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THSYN_RS02545	COG3842	ATPase activity
THSYN_RS02550	COG0390	transport system, permease component
THSYN_RS02565	COG0019	diaminopimelate decarboxylase activity
THSYN_RS02575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THSYN_RS02590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS02645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THSYN_RS02665	COG3150	esterase
THSYN_RS02685	COG0546	phosphoglycolate phosphatase activity
THSYN_RS02685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THSYN_RS02695	COG4221	oxidoreductase activity
THSYN_RS02705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THSYN_RS02710	COG2814	Major facilitator Superfamily
THSYN_RS02730	COG3954	Phosphoribulokinase
THSYN_RS02735	COG1546	Belongs to the CinA family
THSYN_RS02740	COG4067	protein conserved in archaea
THSYN_RS02740	COG0189	ligase activity
THSYN_RS02760	COG1131	(ABC) transporter
THSYN_RS02780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THSYN_RS02790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THSYN_RS02795	COG0312	modulator of DNA gyrase
THSYN_RS02800	COG0312	modulator of DNA gyrase
THSYN_RS02805	COG1231	oxidoreductase activity
THSYN_RS02810	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
THSYN_RS02835	COG2308	Evidence 4 Homologs of previously reported genes of
THSYN_RS02885	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
THSYN_RS02915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THSYN_RS02920	COG1131	(ABC) transporter
THSYN_RS02940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THSYN_RS02980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THSYN_RS02985	COG0475	glutathione-regulated potassium exporter activity
THSYN_RS03000	COG0251	oxidation-reduction process
THSYN_RS03030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THSYN_RS03040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THSYN_RS03050	COG1136	(ABC) transporter
THSYN_RS03050	COG0577	efflux transmembrane transporter activity
THSYN_RS03115	COG0464	growth
THSYN_RS03140	COG0484	heat shock protein binding
THSYN_RS03240	COG0067	glutamate synthase
THSYN_RS03240	COG0070	glutamate synthase
THSYN_RS03240	COG0069	glutamate synthase activity
THSYN_RS03245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THSYN_RS03250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THSYN_RS03255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THSYN_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
THSYN_RS03275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THSYN_RS03295	COG3177	Filamentation induced by cAMP protein fic
THSYN_RS03330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THSYN_RS03340	COG2304	oxidoreductase activity
THSYN_RS03345	COG2304	oxidoreductase activity
THSYN_RS03360	COG0714	Associated with various cellular activities
THSYN_RS03375	COG1752	Esterase of the alpha-beta hydrolase superfamily
THSYN_RS03380	COG3158	transport of potassium into the cell
THSYN_RS03390	COG3158	transport of potassium into the cell
THSYN_RS03425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS03430	COG1196	nuclear chromosome segregation
THSYN_RS03460	COG0494	nUDIX hydrolase
THSYN_RS03465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THSYN_RS03470	COG0653	protein targeting
THSYN_RS03515	COG2001	Belongs to the MraZ family
THSYN_RS03520	COG0275	rRNA processing
THSYN_RS03535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THSYN_RS03540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THSYN_RS03545	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THSYN_RS03550	COG0772	Belongs to the SEDS family
THSYN_RS03555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THSYN_RS03560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THSYN_RS03565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THSYN_RS03570	COG1181	Belongs to the D-alanine--D-alanine ligase family
THSYN_RS03575	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
THSYN_RS03590	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THSYN_RS03600	COG0739	heme binding
THSYN_RS03645	COG4249	Peptidase C14 caspase catalytic subunit p20
THSYN_RS03645	COG2319	Wd-40 repeat
THSYN_RS03665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THSYN_RS03725	COG0557	exoribonuclease II activity
THSYN_RS03785	COG0804	urea catabolic process
THSYN_RS03790	COG0832	Belongs to the urease beta subunit family
THSYN_RS03800	COG0831	urea catabolic process
THSYN_RS03805	COG0829	nickel cation binding
THSYN_RS03810	COG2119	membrane
THSYN_RS03825	COG3045	CreA protein
THSYN_RS03855	COG0586	Pfam SNARE associated Golgi protein
THSYN_RS03860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THSYN_RS03865	COG0352	thiamine-phosphate diphosphorylase activity
THSYN_RS03870	COG0351	phosphomethylpyrimidine kinase
THSYN_RS03890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THSYN_RS03895	COG0316	Belongs to the HesB IscA family
THSYN_RS03900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THSYN_RS03960	COG1278	Cold shock
THSYN_RS03965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THSYN_RS03970	COG0542	response to heat
THSYN_RS03980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THSYN_RS03985	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
THSYN_RS03990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THSYN_RS04000	COG0662	Cupin 2, conserved barrel domain protein
THSYN_RS04030	COG0426	domain, Protein
THSYN_RS04035	COG0633	Ferredoxin
THSYN_RS04065	COG1534	Rna-binding protein
THSYN_RS04070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THSYN_RS04075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THSYN_RS04085	COG0776	regulation of translation
THSYN_RS04105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THSYN_RS04110	COG1136	(ABC) transporter
THSYN_RS04125	COG0628	permease
THSYN_RS04130	COG0864	Transcriptional regulator
THSYN_RS04135	COG0598	Magnesium transport protein CorA
THSYN_RS04145	COG0628	permease
THSYN_RS04165	COG0215	cysteine-tRNA ligase activity
THSYN_RS04200	COG1131	(ABC) transporter
THSYN_RS04235	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THSYN_RS04275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THSYN_RS04280	COG0686	Belongs to the AlaDH PNT family
THSYN_RS04285	COG0626	cystathionine gamma-synthase activity
THSYN_RS04305	COG4115	mRNA cleavage
THSYN_RS04335	COG1192	Involved in chromosome partitioning
THSYN_RS04360	COG2204	response regulator
THSYN_RS04370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THSYN_RS04390	COG0674	pyruvate-flavodoxin oxidoreductase activity
THSYN_RS04390	COG1013	pyruvate-flavodoxin oxidoreductase activity
THSYN_RS04390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THSYN_RS04390	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THSYN_RS04395	COG0167	dihydroorotate dehydrogenase activity
THSYN_RS04395	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THSYN_RS04520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THSYN_RS04520	COG0574	Belongs to the PEP-utilizing enzyme family
THSYN_RS04525	COG0574	Belongs to the PEP-utilizing enzyme family
THSYN_RS04525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THSYN_RS04530	COG4680	protein conserved in bacteria
THSYN_RS04560	COG0574	Belongs to the PEP-utilizing enzyme family
THSYN_RS04560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THSYN_RS04595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS04595	COG0515	serine threonine protein kinase
THSYN_RS04600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS04600	COG0515	serine threonine protein kinase
THSYN_RS04605	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
THSYN_RS04630	COG1131	(ABC) transporter
THSYN_RS04670	COG3842	ATPase activity
THSYN_RS04695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THSYN_RS04715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
THSYN_RS04735	COG1002	Type II restriction enzyme, methylase subunits
THSYN_RS04775	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THSYN_RS04795	COG4804	nuclease activity
THSYN_RS04850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THSYN_RS04855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THSYN_RS04860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THSYN_RS04870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THSYN_RS04875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THSYN_RS04880	COG0126	phosphoglycerate kinase activity
THSYN_RS04890	COG0191	fructose-bisphosphate aldolase activity
THSYN_RS04990	COG1131	(ABC) transporter
THSYN_RS05035	COG3012	SEC-C Motif Domain Protein
THSYN_RS05040	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THSYN_RS05075	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
THSYN_RS05085	COG4208	sulfate ABC transporter
THSYN_RS05090	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THSYN_RS05100	COG1024	Enoyl-CoA hydratase
THSYN_RS05110	COG4636	protein conserved in cyanobacteria
THSYN_RS05115	COG1902	pentaerythritol trinitrate reductase activity
THSYN_RS05125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS05145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THSYN_RS05150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THSYN_RS05155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THSYN_RS05160	COG3178	'Phosphotransferase
THSYN_RS05175	COG2249	NAD(P)H dehydrogenase (quinone) activity
THSYN_RS05215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS05215	COG0515	serine threonine protein kinase
THSYN_RS05270	COG4245	von Willebrand factor, type A
THSYN_RS05290	COG1358	cellular component organization or biogenesis
THSYN_RS05330	COG0590	tRNA wobble adenosine to inosine editing
THSYN_RS05360	COG0300	oxidoreductase activity
THSYN_RS05370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THSYN_RS05375	COG0494	nUDIX hydrolase
THSYN_RS05435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THSYN_RS05455	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THSYN_RS05470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THSYN_RS05475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THSYN_RS05480	COG1674	ftsk spoiiie
THSYN_RS05485	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
THSYN_RS05485	COG2885	chlorophyll binding
THSYN_RS05490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THSYN_RS05540	COG0515	serine threonine protein kinase
THSYN_RS05540	COG2815	serine threonine protein kinase
THSYN_RS05555	COG3706	GGDEF domain
THSYN_RS05555	COG4251	negative regulation of phosphorylation
THSYN_RS05555	COG5001	Diguanylate cyclase
THSYN_RS05555	COG2203	Gaf domain
THSYN_RS05560	COG2815	serine threonine protein kinase
THSYN_RS05560	COG0515	serine threonine protein kinase
THSYN_RS05565	COG4636	protein conserved in cyanobacteria
THSYN_RS05575	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THSYN_RS05600	COG0732	type I restriction modification DNA specificity domain
THSYN_RS05615	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THSYN_RS05620	COG3164	Protein of unknown function
THSYN_RS05630	COG0424	maF-like protein
THSYN_RS05635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THSYN_RS05640	COG0181	hydroxymethylbilane synthase activity
THSYN_RS05645	COG1587	Uroporphyrinogen-III synthase
THSYN_RS05680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THSYN_RS05690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THSYN_RS05700	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THSYN_RS05705	COG0081	regulation of translation
THSYN_RS05710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THSYN_RS05715	COG0222	ribosome binding
THSYN_RS05720	COG0085	RNA polymerase activity
THSYN_RS05725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THSYN_RS05800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THSYN_RS05810	COG0573	inorganic phosphate transmembrane transporter activity
THSYN_RS05825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THSYN_RS05830	COG0717	Belongs to the dCTP deaminase family
THSYN_RS05860	COG0489	protein tyrosine kinase activity
THSYN_RS05865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THSYN_RS05865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THSYN_RS05875	COG0515	serine threonine protein kinase
THSYN_RS05875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS05880	COG1598	PFAM Uncharacterised protein family UPF0150
THSYN_RS05900	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS05910	COG0726	polysaccharide deacetylase
THSYN_RS05910	COG1649	PFAM Uncharacterised BCR, COG1649
THSYN_RS05915	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS05925	COG3264	Mechanosensitive ion channel
THSYN_RS05925	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
THSYN_RS05940	COG0514	ATP-dependent DNA helicase (RecQ)
THSYN_RS05985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THSYN_RS05995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THSYN_RS06010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THSYN_RS06015	COG1573	uracil-dna glycosylase
THSYN_RS06035	COG0653	protein targeting
THSYN_RS06055	COG0515	serine threonine protein kinase
THSYN_RS06055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS06065	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS06160	COG2319	Wd-40 repeat
THSYN_RS06160	COG4249	Peptidase C14 caspase catalytic subunit p20
THSYN_RS06165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THSYN_RS06170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THSYN_RS06215	COG0464	growth
THSYN_RS06275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THSYN_RS06295	COG1960	acyl-CoA dehydrogenase activity
THSYN_RS06310	COG0318	PFAM AMP-dependent synthetase and ligase
THSYN_RS06325	COG2015	COG2015, Alkyl sulfatase and related hydrolases
THSYN_RS06330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THSYN_RS06335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THSYN_RS06345	COG0500	methyltransferase
THSYN_RS06350	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
THSYN_RS06370	COG4974	Belongs to the 'phage' integrase family
THSYN_RS06375	COG0517	IMP dehydrogenase activity
THSYN_RS06395	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
THSYN_RS06425	COG4591	ABC-type transport system involved in lipoprotein release permease component
THSYN_RS06425	COG1136	(ABC) transporter
THSYN_RS06480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THSYN_RS06485	COG2211	Major facilitator Superfamily
THSYN_RS06495	COG0515	serine threonine protein kinase
THSYN_RS06495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS06510	COG0557	exoribonuclease II activity
THSYN_RS06515	COG3108	Peptidase M15
THSYN_RS06525	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
THSYN_RS06535	COG0552	protein localization to endoplasmic reticulum
THSYN_RS06580	COG3385	transposase activity
THSYN_RS06610	COG0702	epimerase
THSYN_RS06615	COG1522	sequence-specific DNA binding
THSYN_RS06620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THSYN_RS06640	COG0033	Phosphoglucomutase
THSYN_RS06645	COG0326	Molecular chaperone. Has ATPase activity
THSYN_RS06655	COG3264	Mechanosensitive ion channel
THSYN_RS06655	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
THSYN_RS06665	COG3119	arylsulfatase activity
THSYN_RS06715	COG0563	adenylate kinase activity
THSYN_RS06720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THSYN_RS06795	COG1215	transferase activity, transferring glycosyl groups
THSYN_RS06805	COG1132	(ABC) transporter
THSYN_RS06810	COG1216	Glycosyl transferase, family 2
THSYN_RS06815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THSYN_RS06820	COG1216	Glycosyl transferase, family 2
THSYN_RS06840	COG0183	Belongs to the thiolase family
THSYN_RS06870	COG1584	GPR1 FUN34 yaaH family protein
THSYN_RS06895	COG0539	negative regulation of cytoplasmic translation
THSYN_RS06900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THSYN_RS06920	COG0719	Fe-S assembly protein
THSYN_RS06925	COG0396	ATPase activity
THSYN_RS06930	COG0719	Fe-S assembly protein
THSYN_RS06935	COG2151	metal-sulfur cluster biosynthetic enzyme
THSYN_RS06945	COG0004	ammonium transporteR
THSYN_RS06955	COG1233	COG1233 Phytoene dehydrogenase and related
THSYN_RS06970	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
THSYN_RS07005	COG1104	cysteine desulfurase activity
THSYN_RS07050	COG3119	arylsulfatase activity
THSYN_RS07065	COG3119	arylsulfatase activity
THSYN_RS07095	COG2766	serine protein kinase
THSYN_RS07100	COG2718	Belongs to the UPF0229 family
THSYN_RS07105	COG2719	SpoVR family
THSYN_RS07140	COG3437	response regulator, receiver
THSYN_RS07140	COG3437	response regulator, receiver
THSYN_RS07150	COG0674	pyruvate-flavodoxin oxidoreductase activity
THSYN_RS07155	COG1013	pyruvate-flavodoxin oxidoreductase activity
THSYN_RS07210	COG0367	asparagine synthase
THSYN_RS07230	COG2813	Specifically methylates the guanine in position
THSYN_RS07245	COG1404	Belongs to the peptidase S8 family
THSYN_RS07295	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THSYN_RS07310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THSYN_RS07315	COG2205	protein histidine kinase activity
THSYN_RS07315	COG0784	Response regulator, receiver
THSYN_RS07330	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THSYN_RS07335	COG4191	Histidine kinase
THSYN_RS07365	COG1793	dna ligase
THSYN_RS07375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THSYN_RS07405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THSYN_RS07410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THSYN_RS07430	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
THSYN_RS07470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THSYN_RS07480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THSYN_RS07485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THSYN_RS07490	COG2716	regulation of RNA biosynthetic process
THSYN_RS07510	COG2234	aminopeptidase activity
THSYN_RS07525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THSYN_RS07535	COG1205	dead DEAH box helicase
THSYN_RS07535	COG1111	helicase
THSYN_RS07540	COG2944	sequence-specific DNA binding
THSYN_RS07550	COG2192	nodulation
THSYN_RS07565	COG0588	phosphoglycerate mutase activity
THSYN_RS07580	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
THSYN_RS07585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THSYN_RS07590	COG1053	succinate dehydrogenase
THSYN_RS07610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THSYN_RS07615	COG1160	GTP binding
THSYN_RS07625	COG2976	Protein conserved in bacteria
THSYN_RS07640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THSYN_RS07645	COG0105	UTP biosynthetic process
THSYN_RS07675	COG0724	RNA recognition motif
THSYN_RS07685	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THSYN_RS07685	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THSYN_RS07690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THSYN_RS07705	COG2189	Belongs to the N(4) N(6)-methyltransferase family
THSYN_RS07720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS07755	COG0745	RESPONSE REGULATOR receiver
THSYN_RS07760	COG0432	Pfam Uncharacterised protein family UPF0047
THSYN_RS07765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THSYN_RS07785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THSYN_RS07795	COG0488	(ABC) transporter
THSYN_RS07870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THSYN_RS07875	COG0058	SHG alpha-glucan phosphorylase activity
THSYN_RS07880	COG3706	GGDEF domain
THSYN_RS07895	COG0012	GTP binding
THSYN_RS07910	COG1177	transmembrane transport
THSYN_RS07915	COG1176	ABC-type spermidine putrescine transport system, permease component I
THSYN_RS07920	COG3842	ATPase activity
THSYN_RS07930	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
THSYN_RS07950	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THSYN_RS07955	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THSYN_RS07960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THSYN_RS07970	COG0140	phosphoribosyl-ATP diphosphatase activity
THSYN_RS07975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THSYN_RS07980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THSYN_RS07990	COG0583	DNA-binding transcription factor activity
THSYN_RS08025	COG1129	ABC transporter
THSYN_RS08065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THSYN_RS08075	COG0501	Belongs to the peptidase M48B family
THSYN_RS08080	COG2010	Cytochrome c
THSYN_RS08115	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THSYN_RS08120	COG1468	defense response to virus
THSYN_RS08120	COG1518	maintenance of DNA repeat elements
THSYN_RS08195	COG2205	protein histidine kinase activity
THSYN_RS08200	COG0745	RESPONSE REGULATOR receiver
THSYN_RS08280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
THSYN_RS08285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THSYN_RS08295	COG1136	(ABC) transporter
THSYN_RS08295	COG0577	efflux transmembrane transporter activity
THSYN_RS08325	COG1131	(ABC) transporter
THSYN_RS08330	COG0842	Transport permease protein
THSYN_RS08335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THSYN_RS08345	COG1199	ATP-dependent helicase activity
THSYN_RS08380	COG0745	RESPONSE REGULATOR receiver
THSYN_RS08410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THSYN_RS08420	COG0366	Alpha amylase catalytic
THSYN_RS08460	COG0745	RESPONSE REGULATOR receiver
THSYN_RS08465	COG2205	protein histidine kinase activity
THSYN_RS08470	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
THSYN_RS08475	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
THSYN_RS08480	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
THSYN_RS08495	COG3737	Protein of unknown function (DUF498/DUF598)
THSYN_RS08515	COG2951	lytic endotransglycosylase activity
THSYN_RS08560	COG1278	Cold shock
THSYN_RS08570	COG0825	malonyl-CoA metabolic process
THSYN_RS08575	COG0037	tRNA processing
THSYN_RS08580	COG3118	belongs to the thioredoxin family
THSYN_RS08620	COG2915	High frequency lysogenization protein hflD homolog
THSYN_RS08640	COG0482	sulfurtransferase activity
THSYN_RS08650	COG1704	LemA family
THSYN_RS08660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THSYN_RS08690	COG0071	Belongs to the small heat shock protein (HSP20) family
THSYN_RS08695	COG2193	ferroxidase activity
THSYN_RS08745	COG0542	response to heat
THSYN_RS08795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THSYN_RS08825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THSYN_RS08845	COG3278	Belongs to the heme-copper respiratory oxidase family
THSYN_RS08860	COG2010	Cytochrome c
THSYN_RS08875	COG2217	Heavy metal translocating P-type atpase
THSYN_RS08895	COG0346	lactoylglutathione lyase activity
THSYN_RS08950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THSYN_RS08980	COG4636	protein conserved in cyanobacteria
THSYN_RS08995	COG4636	protein conserved in cyanobacteria
THSYN_RS09005	COG0415	Belongs to the DNA photolyase family
THSYN_RS09010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS09015	COG1272	protein, Hemolysin III
THSYN_RS09020	COG1686	Belongs to the peptidase S11 family
THSYN_RS09035	COG0784	Response regulator, receiver
THSYN_RS09035	COG2205	protein histidine kinase activity
THSYN_RS09040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THSYN_RS09045	COG3028	Belongs to the UPF0307 family
THSYN_RS09060	COG1122	ATPase activity
THSYN_RS09065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THSYN_RS09070	COG5007	Belongs to the BolA IbaG family
THSYN_RS09080	COG2226	methyltransferase
THSYN_RS09100	COG4783	chaperone-mediated protein folding
THSYN_RS09145	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THSYN_RS09155	COG0156	8-amino-7-oxononanoate synthase activity
THSYN_RS09165	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THSYN_RS09190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THSYN_RS09230	COG4680	protein conserved in bacteria
THSYN_RS09255	COG1842	Phage shock protein A
THSYN_RS09260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS09280	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THSYN_RS09315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THSYN_RS09340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THSYN_RS09350	COG2843	Capsule synthesis protein
THSYN_RS09365	COG3436	PFAM IS66 Orf2 family protein
THSYN_RS09375	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
THSYN_RS09380	COG4181	ATPase activity
THSYN_RS09400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THSYN_RS09420	COG1185	polyribonucleotide nucleotidyltransferase activity
THSYN_RS09425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THSYN_RS09430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THSYN_RS09435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THSYN_RS09440	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THSYN_RS09445	COG0195	Participates in both transcription termination and antitermination
THSYN_RS09450	COG0779	Required for maturation of 30S ribosomal subunits
THSYN_RS09480	COG1472	Belongs to the glycosyl hydrolase 3 family
THSYN_RS09490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THSYN_RS09530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS09545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS09550	COG3001	Fructosamine kinase
THSYN_RS09570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THSYN_RS09580	COG1331	Highly conserved protein containing a thioredoxin domain
THSYN_RS09605	COG3383	formate dehydrogenase (NAD+) activity
THSYN_RS09610	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
THSYN_RS09620	COG3259	Nickel-dependent hydrogenase
THSYN_RS09655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THSYN_RS09675	COG0424	maF-like protein
THSYN_RS09695	COG3436	PFAM IS66 Orf2 family protein
THSYN_RS09725	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
THSYN_RS09745	COG3901	Regulator of nitric oxide reductase transcription
THSYN_RS09745	COG0348	domain, Protein
THSYN_RS09775	COG1355	regulation of microtubule-based process
THSYN_RS09780	COG0596	Alpha beta hydrolase
THSYN_RS09800	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THSYN_RS09800	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THSYN_RS09820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THSYN_RS09830	COG5001	Diguanylate cyclase
THSYN_RS09830	COG4251	negative regulation of phosphorylation
THSYN_RS09830	COG3706	GGDEF domain
THSYN_RS09830	COG2203	Gaf domain
THSYN_RS09865	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THSYN_RS09910	COG2723	6-phospho-beta-galactosidase activity
THSYN_RS09915	COG4178	(ABC) transporter
THSYN_RS09995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THSYN_RS10100	COG3046	protein related to deoxyribodipyrimidine photolyase
THSYN_RS10105	COG0415	Belongs to the DNA photolyase family
THSYN_RS10135	COG0166	Belongs to the GPI family
THSYN_RS10140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THSYN_RS10145	COG0297	glycogen (starch) synthase activity
THSYN_RS10160	COG4680	protein conserved in bacteria
THSYN_RS10180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THSYN_RS10185	COG1678	Uncharacterized ACR, COG1678
THSYN_RS10190	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
THSYN_RS10205	COG2815	serine threonine protein kinase
THSYN_RS10205	COG0515	serine threonine protein kinase
THSYN_RS10215	COG0840	transmembrane signaling receptor activity
THSYN_RS10220	COG0643	Histidine kinase
THSYN_RS10220	COG0643	Histidine kinase
THSYN_RS10220	COG2198	Histidine kinase
THSYN_RS10220	COG2198	Histidine kinase
THSYN_RS10235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THSYN_RS10240	COG0795	lipopolysaccharide-transporting ATPase activity
THSYN_RS10255	COG4191	Histidine kinase
THSYN_RS10260	COG4566	intracellular signal transduction
THSYN_RS10265	COG2270	Major facilitator Superfamily
THSYN_RS10285	COG3154	lipid carrier protein
THSYN_RS10295	COG0826	peptidase U32
THSYN_RS10300	COG0826	peptidase U32
THSYN_RS10305	COG1242	4 iron, 4 sulfur cluster binding
THSYN_RS10325	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THSYN_RS10335	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THSYN_RS10370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THSYN_RS10375	COG0254	rRNA binding
THSYN_RS10400	COG0039	L-malate dehydrogenase activity
THSYN_RS10475	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THSYN_RS10480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THSYN_RS10500	COG1049	propionate catabolic process, 2-methylcitrate cycle
THSYN_RS10505	COG4636	protein conserved in cyanobacteria
THSYN_RS10510	COG3132	Protein of unknown function, DUF480
THSYN_RS10525	COG2850	peptidyl-arginine hydroxylation
THSYN_RS10595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THSYN_RS10600	COG1702	phosphate starvation-inducible protein PhoH
THSYN_RS10605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THSYN_RS10610	COG4535	Mg2 and Co2 transporter CorC
THSYN_RS10615	COG1346	cytolysis
THSYN_RS10620	COG1380	Effector of murein hydrolase LrgA
THSYN_RS10630	COG1401	restriction endodeoxyribonuclease activity
THSYN_RS10655	COG5002	protein histidine kinase activity
THSYN_RS10655	COG2176	DNA-directed DNA polymerase activity
THSYN_RS10660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THSYN_RS10665	COG1393	Belongs to the ArsC family
THSYN_RS10670	COG2171	N-acyltransferase activity
THSYN_RS10675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THSYN_RS10680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
THSYN_RS10730	COG1074	ATP-dependent DNA helicase activity
THSYN_RS10830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THSYN_RS10855	COG3012	SEC-C Motif Domain Protein
THSYN_RS10865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
THSYN_RS10880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THSYN_RS10885	COG0066	3-isopropylmalate dehydratase activity
THSYN_RS10890	COG0473	3-isopropylmalate dehydrogenase activity
THSYN_RS10905	COG0101	tRNA pseudouridine synthase activity
THSYN_RS10910	COG0135	phosphoribosylanthranilate isomerase activity
THSYN_RS10915	COG0133	tryptophan synthase activity
THSYN_RS10920	COG0159	tryptophan synthase activity
THSYN_RS10925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THSYN_RS10970	COG0285	dihydrofolate synthase activity
THSYN_RS11005	COG0765	amino acid transport
THSYN_RS11010	COG0765	amino acid transport
THSYN_RS11015	COG1126	abc transporter atp-binding protein
THSYN_RS11050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THSYN_RS11055	COG1187	pseudouridine synthase activity
THSYN_RS11060	COG3609	addiction module antidote protein, CC2985 family
THSYN_RS11085	COG0116	Belongs to the methyltransferase superfamily
THSYN_RS11085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THSYN_RS11105	COG3437	response regulator, receiver
THSYN_RS11135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THSYN_RS11140	COG0018	arginyl-trna synthetase
THSYN_RS11155	COG0028	Belongs to the TPP enzyme family
THSYN_RS11180	COG4383	Mu-like prophage protein gp29
THSYN_RS11190	COG2369	cell adhesion
THSYN_RS11210	COG4397	Mu-like prophage major head subunit gpT
THSYN_RS11285	COG0483	inositol monophosphate 1-phosphatase activity
THSYN_RS11290	COG0741	lytic transglycosylase activity
THSYN_RS11300	COG0163	prenyltransferase activity
THSYN_RS11310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THSYN_RS11335	COG2321	neutral zinc metallopeptidase
THSYN_RS11365	COG0517	IMP dehydrogenase activity
THSYN_RS11370	COG4974	Belongs to the 'phage' integrase family
THSYN_RS11390	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
THSYN_RS11460	COG1012	belongs to the aldehyde dehydrogenase family
THSYN_RS11565	COG0517	IMP dehydrogenase activity
THSYN_RS11570	COG4974	Belongs to the 'phage' integrase family
THSYN_RS11575	COG3344	reverse transcriptase
THSYN_RS11585	COG0517	IMP dehydrogenase activity
THSYN_RS11590	COG4974	Belongs to the 'phage' integrase family
THSYN_RS11610	COG2226	methyltransferase
THSYN_RS11615	COG2267	carboxylic ester hydrolase activity
THSYN_RS11620	COG0156	8-amino-7-oxononanoate synthase activity
THSYN_RS11625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THSYN_RS11635	COG1882	Formate acetyltransferase
THSYN_RS11665	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THSYN_RS11675	COG1196	nuclear chromosome segregation
THSYN_RS11675	COG0741	lytic transglycosylase activity
THSYN_RS11675	COG0739	heme binding
THSYN_RS11700	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
THSYN_RS11715	COG0297	glycogen (starch) synthase activity
THSYN_RS11720	COG5002	protein histidine kinase activity
THSYN_RS11720	COG3447	MASE1 domain protein
THSYN_RS11720	COG5001	Diguanylate cyclase
THSYN_RS11730	COG0551	DNA topoisomerase type I activity
THSYN_RS11730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THSYN_RS11760	COG2969	positive regulation of protein catabolic process
THSYN_RS11765	COG0625	glutathione transferase activity
THSYN_RS11770	COG2857	Cytochrome c1
THSYN_RS11775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THSYN_RS11780	COG0723	plastoquinol--plastocyanin reductase activity
THSYN_RS11785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THSYN_RS11800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THSYN_RS11815	COG0489	protein tyrosine kinase activity
THSYN_RS11830	COG0129	dihydroxy-acid dehydratase activity
THSYN_RS11835	COG1943	Transposase
THSYN_RS11850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THSYN_RS11950	COG2204	response regulator
THSYN_RS11955	COG0436	Aminotransferase
THSYN_RS11980	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THSYN_RS12105	COG0631	protein serine/threonine phosphatase activity
THSYN_RS12120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS12145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THSYN_RS12150	COG0726	polysaccharide deacetylase
THSYN_RS12160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS12170	COG0011	TIGRFAM Protein of
THSYN_RS12175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS12175	COG0515	serine threonine protein kinase
THSYN_RS12195	COG3920	Histidine kinase
THSYN_RS12205	COG1234	tRNA 3'-trailer cleavage
THSYN_RS12270	COG0745	RESPONSE REGULATOR receiver
THSYN_RS12270	COG4191	Histidine kinase
THSYN_RS12270	COG2205	protein histidine kinase activity
THSYN_RS12275	COG4566	intracellular signal transduction
THSYN_RS12280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THSYN_RS12285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THSYN_RS12295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS12300	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THSYN_RS12325	COG3550	peptidyl-serine autophosphorylation
THSYN_RS12345	COG0386	Belongs to the glutathione peroxidase family
THSYN_RS12380	COG0784	Response regulator, receiver
THSYN_RS12380	COG5002	protein histidine kinase activity
THSYN_RS12415	COG1703	isobutyryl-CoA mutase activity
THSYN_RS12420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THSYN_RS12420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THSYN_RS12425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THSYN_RS12440	COG1024	Enoyl-CoA hydratase
THSYN_RS12460	COG2205	protein histidine kinase activity
THSYN_RS12465	COG0745	RESPONSE REGULATOR receiver
THSYN_RS12495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS12505	COG2815	serine threonine protein kinase
THSYN_RS12505	COG0515	serine threonine protein kinase
THSYN_RS12515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS12520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THSYN_RS12525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
THSYN_RS12530	COG0443	Heat shock 70 kDa protein
THSYN_RS12540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS12555	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS12615	COG4591	ABC-type transport system involved in lipoprotein release permease component
THSYN_RS12620	COG1136	(ABC) transporter
THSYN_RS12650	COG2205	protein histidine kinase activity
THSYN_RS12680	COG5654	RES domain protein
THSYN_RS12695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THSYN_RS12705	COG2951	lytic endotransglycosylase activity
THSYN_RS12730	COG0408	coproporphyrinogen oxidase activity
THSYN_RS12750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THSYN_RS12770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THSYN_RS12775	COG0649	NAD binding
THSYN_RS12780	COG0651	ATP synthesis coupled electron transport
THSYN_RS12790	COG0650	Formate hydrogenlyase subunit 4
THSYN_RS12795	COG0651	ATP synthesis coupled electron transport
THSYN_RS12810	COG1607	acyl-coa hydrolase
THSYN_RS12820	COG0210	DNA helicase
THSYN_RS12850	COG2197	response regulator
THSYN_RS12865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THSYN_RS12875	COG0322	excinuclease ABC activity
THSYN_RS12880	COG0288	reversible hydration of carbon dioxide
THSYN_RS12900	COG2354	Protein conserved in bacteria
THSYN_RS12910	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
THSYN_RS12920	COG0579	oxidoreductase
THSYN_RS12935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
THSYN_RS12940	COG1918	ferrous iron import across plasma membrane
THSYN_RS12995	COG5001	Diguanylate cyclase
THSYN_RS12995	COG3300	MHYT domain
THSYN_RS13000	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
THSYN_RS13010	COG2943	transferase activity, transferring hexosyl groups
THSYN_RS13040	COG1120	ATPase activity
THSYN_RS13045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THSYN_RS13050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THSYN_RS13060	COG0613	PHP domain protein
THSYN_RS13065	COG0009	L-threonylcarbamoyladenylate synthase
THSYN_RS13070	COG1994	Peptidase M50
THSYN_RS13075	COG0180	Tryptophanyl-tRNA synthetase
THSYN_RS13080	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THSYN_RS13085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THSYN_RS13120	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
THSYN_RS13125	COG2086	electron transfer activity
THSYN_RS13130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THSYN_RS13135	COG1960	acyl-CoA dehydrogenase activity
THSYN_RS13165	COG0601	transmembrane transport
THSYN_RS13170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THSYN_RS13220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THSYN_RS13230	COG0513	Belongs to the DEAD box helicase family
THSYN_RS13235	COG1011	Hydrolase
THSYN_RS13240	COG0494	nUDIX hydrolase
THSYN_RS13250	COG0857	belongs to the CobB CobQ family
THSYN_RS13250	COG0280	phosphate acetyltransferase
THSYN_RS13260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THSYN_RS13285	COG0670	Belongs to the BI1 family
THSYN_RS13330	COG2815	serine threonine protein kinase
THSYN_RS13330	COG0515	serine threonine protein kinase
THSYN_RS13335	COG1122	ATPase activity
THSYN_RS13345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THSYN_RS13355	COG1850	ribulose-bisphosphate carboxylase activity
THSYN_RS13385	COG2824	Alkylphosphonate utilization operon protein PhnA
THSYN_RS13410	COG3577	Aspartyl protease
THSYN_RS13425	COG1040	competence protein
THSYN_RS13440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THSYN_RS13470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THSYN_RS13495	COG4636	protein conserved in cyanobacteria
THSYN_RS13500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS13510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THSYN_RS13540	COG0360	Binds together with S18 to 16S ribosomal RNA
THSYN_RS13545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THSYN_RS13555	COG0359	binds to the 23S rRNA
THSYN_RS13565	COG0860	N-Acetylmuramoyl-L-alanine amidase
THSYN_RS13570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THSYN_RS13590	COG2130	NADP-dependent
THSYN_RS13620	COG2307	Protein conserved in bacteria
THSYN_RS13620	COG2308	Evidence 4 Homologs of previously reported genes of
THSYN_RS13665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THSYN_RS13695	COG2379	hydroxypyruvate reductase
THSYN_RS13700	COG4932	domain protein
THSYN_RS13700	COG5492	domain, Protein
THSYN_RS13720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THSYN_RS13740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THSYN_RS13760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS13805	COG0330	HflC and HflK could
THSYN_RS13830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THSYN_RS13870	COG5002	protein histidine kinase activity
THSYN_RS13870	COG3850	Histidine kinase
THSYN_RS13940	COG1940	carbohydrate kinase activity
THSYN_RS13990	COG3620	sequence-specific DNA binding
THSYN_RS14095	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
THSYN_RS14105	COG0366	Alpha amylase catalytic
THSYN_RS14105	COG1874	Beta-galactosidase
THSYN_RS14130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS14135	COG2319	Wd-40 repeat
THSYN_RS14135	COG4249	Peptidase C14 caspase catalytic subunit p20
THSYN_RS14140	COG2319	Wd-40 repeat
THSYN_RS14140	COG4249	Peptidase C14 caspase catalytic subunit p20
THSYN_RS14145	COG1183	phosphatidylcholine synthase activity
THSYN_RS14155	COG4178	(ABC) transporter
THSYN_RS14190	COG3038	cytochrome b561
THSYN_RS14195	COG2205	protein histidine kinase activity
THSYN_RS14205	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
THSYN_RS14210	COG4251	negative regulation of phosphorylation
THSYN_RS14245	COG4804	nuclease activity
THSYN_RS14250	COG3954	Phosphoribulokinase
THSYN_RS14265	COG2204	response regulator
THSYN_RS14290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THSYN_RS14305	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
THSYN_RS14320	COG0798	PFAM Bile acid sodium symporter
THSYN_RS14375	COG0730	response to heat
THSYN_RS14490	COG2183	response to ionizing radiation
THSYN_RS14515	COG1408	metallophosphoesterase
THSYN_RS14530	COG1408	metallophosphoesterase
THSYN_RS14540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THSYN_RS14545	COG4974	Belongs to the 'phage' integrase family
THSYN_RS14560	COG1666	GTP binding
THSYN_RS14565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
THSYN_RS14570	COG0631	protein serine/threonine phosphatase activity
THSYN_RS14580	COG3842	ATPase activity
THSYN_RS14585	COG1176	ABC-type spermidine putrescine transport system, permease component I
THSYN_RS14590	COG1840	ABC-type Fe3 transport system, periplasmic component
THSYN_RS14610	COG1132	(ABC) transporter
THSYN_RS14625	COG0535	radical SAM domain protein
THSYN_RS14645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THSYN_RS14665	COG1506	peptidase
THSYN_RS14665	COG0823	Involved in the tonB-independent uptake of proteins
THSYN_RS14690	COG1320	monovalent cation:proton antiporter activity
THSYN_RS14695	COG2212	antiporter activity
THSYN_RS14710	COG0651	ATP synthesis coupled electron transport
THSYN_RS14715	COG1006	Multisubunit Na H antiporter MnhC subunit
THSYN_RS14720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THSYN_RS14720	COG2111	Na H antiporter
THSYN_RS14730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS14750	COG1132	(ABC) transporter
THSYN_RS14760	COG0768	penicillin binding
THSYN_RS14790	COG2205	protein histidine kinase activity
THSYN_RS14840	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THSYN_RS14850	COG3447	MASE1 domain protein
THSYN_RS14850	COG5001	Diguanylate cyclase
THSYN_RS14850	COG5002	protein histidine kinase activity
THSYN_RS14910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THSYN_RS14920	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THSYN_RS14945	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS14955	COG1136	(ABC) transporter
THSYN_RS15045	COG0714	Associated with various cellular activities
THSYN_RS15115	COG1501	Belongs to the glycosyl hydrolase 31 family
THSYN_RS15160	COG2337	Toxic component of a toxin-antitoxin (TA) module
THSYN_RS15215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THSYN_RS15220	COG0842	Transport permease protein
THSYN_RS15220	COG1129	ABC transporter
THSYN_RS15225	COG0842	Transport permease protein
THSYN_RS15275	COG1538	Outer membrane efflux protein
THSYN_RS15285	COG0577	efflux transmembrane transporter activity
THSYN_RS15285	COG1136	(ABC) transporter
THSYN_RS15290	COG1136	(ABC) transporter
THSYN_RS15290	COG0577	efflux transmembrane transporter activity
THSYN_RS15310	COG2814	Major facilitator Superfamily
THSYN_RS15380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THSYN_RS15385	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THSYN_RS15495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THSYN_RS15545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS15575	COG2204	response regulator
THSYN_RS15645	COG3961	Belongs to the TPP enzyme family
THSYN_RS15700	COG0745	RESPONSE REGULATOR receiver
THSYN_RS15725	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THSYN_RS15730	COG2894	cell division
THSYN_RS15735	COG0850	regulation of cytokinetic process
THSYN_RS15740	COG0537	adenosine 5'-monophosphoramidase activity
THSYN_RS15745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THSYN_RS15755	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THSYN_RS15765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
THSYN_RS15775	COG0330	HflC and HflK could
THSYN_RS15780	COG0330	HflC and HflK could
THSYN_RS15785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THSYN_RS15790	COG1923	regulation of RNA biosynthetic process
THSYN_RS15795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THSYN_RS15800	COG1131	(ABC) transporter
THSYN_RS15815	COG1877	trehalose-phosphatase activity
THSYN_RS15820	COG3387	PFAM Glycoside hydrolase 15-related
THSYN_RS15895	COG2199	diguanylate cyclase activity
THSYN_RS15895	COG2203	Gaf domain
THSYN_RS15910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THSYN_RS15920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THSYN_RS15955	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THSYN_RS16075	COG2022	thiamine diphosphate biosynthetic process
THSYN_RS16095	COG3206	protein involved in exopolysaccharide biosynthesis
THSYN_RS16095	COG0489	protein tyrosine kinase activity
THSYN_RS16110	COG0490	domain, Protein
THSYN_RS16110	COG0471	metal ion transport
THSYN_RS16120	COG2095	MarC family integral membrane protein
THSYN_RS16155	COG0084	hydrolase, TatD family'
THSYN_RS16170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THSYN_RS16175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THSYN_RS16185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THSYN_RS16190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THSYN_RS16205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THSYN_RS16210	COG0416	fatty acid biosynthetic process
THSYN_RS16215	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THSYN_RS16220	COG1399	metal-binding, possibly nucleic acid-binding protein
THSYN_RS16300	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THSYN_RS16310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THSYN_RS16315	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THSYN_RS16330	COG4636	protein conserved in cyanobacteria
THSYN_RS16345	COG3568	Endonuclease Exonuclease Phosphatase
THSYN_RS16345	COG1555	photosystem II stabilization
THSYN_RS16350	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
THSYN_RS16385	COG0259	pyridoxamine-phosphate oxidase activity
THSYN_RS16430	COG0577	efflux transmembrane transporter activity
THSYN_RS16430	COG1136	(ABC) transporter
THSYN_RS16435	COG0525	valine-tRNA ligase activity
THSYN_RS16445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THSYN_RS16455	COG0463	Glycosyl transferase, family 2
THSYN_RS16460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THSYN_RS16465	COG0463	Glycosyl transferase, family 2
THSYN_RS16475	COG1216	Glycosyl transferase, family 2
THSYN_RS16480	COG3302	dmso reductase anchor subunit
THSYN_RS16485	COG0437	4 iron, 4 sulfur cluster binding
THSYN_RS16495	COG0243	molybdopterin cofactor binding
THSYN_RS16500	COG2046	Belongs to the sulfate adenylyltransferase family
THSYN_RS16535	COG2048	Heterodisulfide reductase, subunit B
THSYN_RS16540	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THSYN_RS16545	COG1233	COG1233 Phytoene dehydrogenase and related
THSYN_RS16550	COG0723	plastoquinol--plastocyanin reductase activity
THSYN_RS16550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THSYN_RS16555	COG0045	succinate-CoA ligase (ADP-forming) activity
THSYN_RS16590	COG0281	malic enzyme
THSYN_RS16590	COG0280	phosphate acetyltransferase
THSYN_RS16600	COG1902	pentaerythritol trinitrate reductase activity
THSYN_RS16620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THSYN_RS16625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THSYN_RS16665	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
THSYN_RS16690	COG4681	YaeQ
THSYN_RS16700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THSYN_RS16700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THSYN_RS16705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THSYN_RS16710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THSYN_RS16715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THSYN_RS16720	COG1028	Short-chain dehydrogenase reductase Sdr
THSYN_RS16730	COG1741	Belongs to the pirin family
THSYN_RS16810	COG0165	Argininosuccinate lyase
THSYN_RS16815	COG3275	phosphorelay sensor kinase activity
THSYN_RS16830	COG0367	asparagine synthase
THSYN_RS16840	COG1216	Glycosyl transferase, family 2
THSYN_RS16845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THSYN_RS16850	COG1879	ABC-type sugar transport system periplasmic component
THSYN_RS16855	COG5001	Diguanylate cyclase
THSYN_RS16860	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
THSYN_RS16870	COG1968	undecaprenyl-diphosphatase activity
THSYN_RS16875	COG0515	serine threonine protein kinase
THSYN_RS16875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS16890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
THSYN_RS16890	COG1263	PTS System
THSYN_RS16920	COG0457	Tetratricopeptide repeat
THSYN_RS16940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THSYN_RS16970	COG0837	glucose binding
THSYN_RS16985	COG2204	response regulator
THSYN_RS17015	COG0517	IMP dehydrogenase activity
THSYN_RS17020	COG4974	Belongs to the 'phage' integrase family
THSYN_RS17025	COG3344	reverse transcriptase
THSYN_RS17045	COG1366	Belongs to the anti-sigma-factor antagonist family
THSYN_RS17065	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS17075	COG0110	maltose O-acetyltransferase activity
THSYN_RS17175	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
THSYN_RS17200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THSYN_RS17205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THSYN_RS17225	COG0741	lytic transglycosylase activity
THSYN_RS17245	COG0515	serine threonine protein kinase
THSYN_RS17245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS17250	COG1943	Transposase
THSYN_RS17270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
THSYN_RS17275	COG4636	protein conserved in cyanobacteria
THSYN_RS17325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS17370	COG0402	S-adenosylhomocysteine deaminase activity
THSYN_RS17385	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS17425	COG1376	ErfK ybiS ycfS ynhG family protein
THSYN_RS17430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THSYN_RS17430	COG1648	precorrin-2 dehydrogenase activity
THSYN_RS17435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THSYN_RS17440	COG0425	Belongs to the sulfur carrier protein TusA family
THSYN_RS17445	COG2210	Belongs to the sulfur carrier protein TusA family
THSYN_RS17485	COG3416	Protein conserved in bacteria
THSYN_RS17535	COG2198	Histidine kinase
THSYN_RS17535	COG2205	protein histidine kinase activity
THSYN_RS17535	COG0784	Response regulator, receiver
THSYN_RS17550	COG3852	Histidine kinase
THSYN_RS17625	COG4566	intracellular signal transduction
THSYN_RS17650	COG1858	cytochrome C peroxidase
THSYN_RS17655	COG4106	trans-aconitate 2-methyltransferase activity
THSYN_RS17670	COG0704	Plays a role in the regulation of phosphate uptake
THSYN_RS17710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THSYN_RS17715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS17755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THSYN_RS17760	COG0586	Pfam SNARE associated Golgi protein
THSYN_RS17790	COG1643	Atp-dependent helicase
THSYN_RS17810	COG0617	tRNA 3'-terminal CCA addition
THSYN_RS17815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THSYN_RS17820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THSYN_RS17825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THSYN_RS17830	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THSYN_RS17860	COG1598	PFAM Uncharacterised protein family UPF0150
THSYN_RS17885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THSYN_RS17905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THSYN_RS17910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THSYN_RS17915	COG0740	serine-type endopeptidase activity
THSYN_RS17920	COG0544	peptidyl-prolyl cis-trans isomerase activity
THSYN_RS17940	COG0456	acetyltransferase
THSYN_RS17950	COG1999	signal sequence binding
THSYN_RS17965	COG3119	arylsulfatase activity
THSYN_RS18020	COG3038	cytochrome b561
THSYN_RS18025	COG2353	YceI-like domain
THSYN_RS18150	COG3119	arylsulfatase activity
THSYN_RS18190	COG0471	metal ion transport
THSYN_RS18190	COG0490	domain, Protein
THSYN_RS18210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THSYN_RS18245	COG0628	permease
THSYN_RS18250	COG1454	alcohol dehydrogenase
THSYN_RS18270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THSYN_RS18280	COG5433	transposase activity
THSYN_RS18295	COG3436	PFAM IS66 Orf2 family protein
THSYN_RS18320	COG4245	von Willebrand factor, type A
THSYN_RS18325	COG3077	Addiction module antitoxin, RelB DinJ family
THSYN_RS18335	COG3119	arylsulfatase activity
THSYN_RS18340	COG0641	radical SAM
THSYN_RS18350	COG0628	permease
THSYN_RS18385	COG2003	Belongs to the UPF0758 family
THSYN_RS18425	COG2066	Belongs to the glutaminase family
THSYN_RS18435	COG0786	glutamate:sodium symporter activity
THSYN_RS18455	COG1007	ATP synthesis coupled electron transport
THSYN_RS18465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THSYN_RS18465	COG2111	Na H antiporter
THSYN_RS18470	COG1320	monovalent cation:proton antiporter activity
THSYN_RS18490	COG2610	gluconate transmembrane transporter activity
THSYN_RS18520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THSYN_RS18530	COG0210	DNA helicase
THSYN_RS18545	COG3744	PilT protein domain protein
THSYN_RS18580	COG0322	excinuclease ABC activity
THSYN_RS18585	COG2197	response regulator
THSYN_RS18595	COG0840	transmembrane signaling receptor activity
THSYN_RS18610	COG2201	protein-glutamate methylesterase activity
THSYN_RS18615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THSYN_RS18620	COG2205	protein histidine kinase activity
THSYN_RS18620	COG0784	Response regulator, receiver
THSYN_RS18620	COG5002	protein histidine kinase activity
THSYN_RS18625	COG3447	MASE1 domain protein
THSYN_RS18625	COG5001	Diguanylate cyclase
THSYN_RS18625	COG5002	protein histidine kinase activity
THSYN_RS18635	COG3436	PFAM IS66 Orf2 family protein
THSYN_RS18745	COG0443	Heat shock 70 kDa protein
THSYN_RS18755	COG2823	Periplasmic or secreted lipoprotein
THSYN_RS18780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS18790	COG0729	surface antigen
THSYN_RS18800	COG1850	ribulose-bisphosphate carboxylase activity
THSYN_RS18870	COG0436	Aminotransferase
THSYN_RS18975	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THSYN_RS18980	COG5557	Pfam Polysulphide reductase, NrfD
THSYN_RS18985	COG0437	4 iron, 4 sulfur cluster binding
THSYN_RS18990	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
THSYN_RS19055	COG1271	oxidase subunit
THSYN_RS19060	COG1294	oxidase, subunit
THSYN_RS19065	COG4890	Cyd operon protein YbgT
THSYN_RS19070	COG4988	ABC transporter
THSYN_RS19075	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
THSYN_RS19085	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
THSYN_RS19110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS19110	COG0515	serine threonine protein kinase
THSYN_RS19115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS19115	COG0515	serine threonine protein kinase
THSYN_RS19135	COG0310	cobalt ion transport
THSYN_RS19190	COG3746	phosphate-selective porin O and P
THSYN_RS19195	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
THSYN_RS19200	COG1121	(ABC) transporter
THSYN_RS19220	COG3609	addiction module antidote protein, CC2985 family
THSYN_RS19240	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
THSYN_RS19245	COG0310	cobalt ion transport
THSYN_RS19260	COG0446	pyridine nucleotide-disulphide oxidoreductase
THSYN_RS19270	COG2894	cell division
THSYN_RS19295	COG0450	alkyl hydroperoxide reductase
THSYN_RS19305	COG3909	cytochrome
THSYN_RS19335	COG3459	Glycosyltransferase 36 associated
THSYN_RS19355	COG3437	response regulator, receiver
THSYN_RS19365	COG4636	protein conserved in cyanobacteria
THSYN_RS19375	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THSYN_RS19380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THSYN_RS19430	COG1518	maintenance of DNA repeat elements
THSYN_RS19435	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THSYN_RS19440	COG3264	Mechanosensitive ion channel
THSYN_RS19440	COG1196	nuclear chromosome segregation
THSYN_RS19445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THSYN_RS19450	COG1653	transport
THSYN_RS19455	COG0795	lipopolysaccharide-transporting ATPase activity
THSYN_RS19470	COG4245	von Willebrand factor, type A
THSYN_RS19475	COG0515	serine threonine protein kinase
THSYN_RS19475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS19480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS19535	COG0436	Aminotransferase
THSYN_RS19545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THSYN_RS19585	COG0271	Belongs to the BolA IbaG family
THSYN_RS19620	COG2917	probably involved in intracellular septation
THSYN_RS19625	COG2350	Protein conserved in bacteria
THSYN_RS19630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THSYN_RS19635	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS19640	COG0501	Belongs to the peptidase M48B family
THSYN_RS19660	COG0433	COG0433 Predicted ATPase
THSYN_RS19680	COG0277	FAD linked oxidase domain protein
THSYN_RS19685	COG2255	four-way junction helicase activity
THSYN_RS19720	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
THSYN_RS19740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THSYN_RS19760	COG0612	Peptidase, M16
THSYN_RS19765	COG0612	Peptidase, M16
THSYN_RS19770	COG0742	ribosomal rna small subunit methyltransferase
THSYN_RS19775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THSYN_RS19780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THSYN_RS19790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THSYN_RS19830	COG0737	Belongs to the 5'-nucleotidase family
THSYN_RS19895	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
THSYN_RS19900	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
THSYN_RS19960	COG3550	peptidyl-serine autophosphorylation
THSYN_RS19970	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
THSYN_RS19975	COG4251	negative regulation of phosphorylation
THSYN_RS19980	COG4251	negative regulation of phosphorylation
THSYN_RS19990	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
THSYN_RS20015	COG0628	permease
THSYN_RS20020	COG2818	Glycosylase
THSYN_RS20025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THSYN_RS20030	COG0494	nUDIX hydrolase
THSYN_RS20060	COG0308	aminopeptidase N
THSYN_RS20065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
THSYN_RS20070	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THSYN_RS20075	COG0429	hydrolase of the alpha beta-hydrolase fold
THSYN_RS20110	COG4589	Belongs to the CDS family
THSYN_RS20115	COG0589	response to stress
THSYN_RS20120	COG0439	Biotin carboxylase
THSYN_RS20125	COG5016	pyruvate
THSYN_RS20125	COG0511	ligase activity, forming carbon-carbon bonds
THSYN_RS20165	COG0588	phosphoglycerate mutase activity
THSYN_RS20320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THSYN_RS20325	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THSYN_RS20355	COG4680	protein conserved in bacteria
THSYN_RS20360	COG0585	pseudouridine synthase activity
THSYN_RS20365	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THSYN_RS20370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THSYN_RS20375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
THSYN_RS20380	COG0148	phosphopyruvate hydratase activity
THSYN_RS20385	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THSYN_RS20390	COG0504	CTP synthase activity
THSYN_RS20400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THSYN_RS20475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THSYN_RS20480	COG0328	RNA-DNA hybrid ribonuclease activity
THSYN_RS20490	COG1388	LysM domain
THSYN_RS20490	COG0741	lytic transglycosylase activity
THSYN_RS20500	COG1032	radical SAM domain protein
THSYN_RS20540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THSYN_RS20545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THSYN_RS20550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THSYN_RS20575	COG4245	von Willebrand factor, type A
THSYN_RS20575	COG4245	von Willebrand factor, type A
THSYN_RS20585	COG2922	Belongs to the Smg family
THSYN_RS20590	COG0758	DNA mediated transformation
THSYN_RS20600	COG0242	peptide deformylase activity
THSYN_RS20605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THSYN_RS20620	COG5000	phosphorelay sensor kinase activity
THSYN_RS20625	COG2204	response regulator
THSYN_RS20645	COG2813	Specifically methylates the guanine in position
THSYN_RS20650	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THSYN_RS20680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THSYN_RS20685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THSYN_RS20690	COG2003	Belongs to the UPF0758 family
THSYN_RS20695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THSYN_RS20710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THSYN_RS20740	COG1872	DUF167
THSYN_RS20745	COG0517	IMP dehydrogenase activity
THSYN_RS20755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THSYN_RS20755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THSYN_RS20780	COG0653	protein targeting
THSYN_RS20790	COG4413	Urea transporter
THSYN_RS20810	COG0287	Prephenate dehydrogenase
THSYN_RS20815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THSYN_RS20820	COG0077	Prephenate dehydratase
THSYN_RS20820	COG1605	Chorismate mutase
THSYN_RS20825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THSYN_RS20830	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THSYN_RS20885	COG5002	protein histidine kinase activity
THSYN_RS20890	COG0745	RESPONSE REGULATOR receiver
THSYN_RS20905	COG1451	nucleotide metabolic process
THSYN_RS20915	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THSYN_RS20950	COG4804	nuclease activity
THSYN_RS20980	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THSYN_RS20990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THSYN_RS21000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THSYN_RS21065	COG0268	Binds directly to 16S ribosomal RNA
THSYN_RS21120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THSYN_RS21140	COG0196	riboflavin kinase activity
THSYN_RS21175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THSYN_RS21195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THSYN_RS21205	COG0189	ligase activity
THSYN_RS21215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THSYN_RS21230	COG3409	Peptidoglycan-binding domain 1 protein
THSYN_RS21230	COG3267	Type II secretory pathway component ExeA
THSYN_RS21240	COG1215	transferase activity, transferring glycosyl groups
THSYN_RS21260	COG5001	Diguanylate cyclase
THSYN_RS21260	COG5002	protein histidine kinase activity
THSYN_RS21265	COG0488	(ABC) transporter
THSYN_RS21270	COG1763	Mo-molybdopterin cofactor biosynthetic process
THSYN_RS21285	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
THSYN_RS21310	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS21315	COG0367	asparagine synthase
THSYN_RS21350	COG3267	Type II secretory pathway component ExeA
THSYN_RS21350	COG3409	Peptidoglycan-binding domain 1 protein
THSYN_RS21360	COG0489	protein tyrosine kinase activity
THSYN_RS21370	COG1596	polysaccharide export
THSYN_RS21375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THSYN_RS21380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THSYN_RS21385	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
THSYN_RS21390	COG0058	SHG alpha-glucan phosphorylase activity
THSYN_RS21410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THSYN_RS21485	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THSYN_RS21490	COG1201	RNA secondary structure unwinding
THSYN_RS21530	COG3264	Mechanosensitive ion channel
THSYN_RS21530	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
THSYN_RS21540	COG0248	Ppx GppA phosphatase
THSYN_RS21625	COG0802	atpase or kinase
THSYN_RS21630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THSYN_RS21630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THSYN_RS21635	COG0297	glycogen (starch) synthase activity
THSYN_RS21715	COG2814	Major facilitator Superfamily
THSYN_RS21720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THSYN_RS21725	COG1538	Outer membrane efflux protein
THSYN_RS21755	COG3609	addiction module antidote protein, CC2985 family
THSYN_RS21765	COG3876	Protein conserved in bacteria
THSYN_RS21790	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS21795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THSYN_RS21815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THSYN_RS21850	COG2252	PERMEase
THSYN_RS21920	COG3706	GGDEF domain
THSYN_RS21920	COG4251	negative regulation of phosphorylation
THSYN_RS21920	COG5001	Diguanylate cyclase
THSYN_RS21920	COG2203	Gaf domain
THSYN_RS21925	COG5002	protein histidine kinase activity
THSYN_RS21925	COG5001	Diguanylate cyclase
THSYN_RS21925	COG3447	MASE1 domain protein
THSYN_RS21935	COG4636	protein conserved in cyanobacteria
THSYN_RS21955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THSYN_RS21965	COG4456	Virulence-associated protein
THSYN_RS21985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THSYN_RS22000	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THSYN_RS22010	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THSYN_RS22015	COG0575	Belongs to the CDS family
THSYN_RS22020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THSYN_RS22025	COG0233	cytoplasmic translational termination
THSYN_RS22030	COG0528	UMP kinase activity
THSYN_RS22035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THSYN_RS22040	COG0052	Belongs to the universal ribosomal protein uS2 family
THSYN_RS22045	COG0024	Methionine aminopeptidase
THSYN_RS22050	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THSYN_RS22075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THSYN_RS22080	COG0284	orotidine-5'-phosphate decarboxylase activity
THSYN_RS22085	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
THSYN_RS22095	COG3629	intracellular signal transduction
THSYN_RS22095	COG3903	Transcriptional regulator
THSYN_RS22105	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THSYN_RS22105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THSYN_RS22125	COG0830	nickel cation binding
THSYN_RS22130	COG2249	NAD(P)H dehydrogenase (quinone) activity
THSYN_RS22135	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
THSYN_RS22150	COG0617	tRNA 3'-terminal CCA addition
THSYN_RS22200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THSYN_RS22205	COG0509	glycine decarboxylation via glycine cleavage system
THSYN_RS22210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THSYN_RS22215	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
THSYN_RS22220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THSYN_RS22230	COG0521	Mo-molybdopterin cofactor biosynthetic process
THSYN_RS22235	COG0303	'Molybdopterin
THSYN_RS22240	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THSYN_RS22250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS22255	COG1105	Belongs to the carbohydrate kinase PfkB family
THSYN_RS22280	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
THSYN_RS22290	COG0546	phosphoglycolate phosphatase activity
THSYN_RS22310	COG0217	transcriptional regulatory protein
THSYN_RS22315	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THSYN_RS22320	COG0632	four-way junction helicase activity
THSYN_RS22325	COG4636	protein conserved in cyanobacteria
THSYN_RS22385	COG3853	Toxic anion resistance protein (TelA)
THSYN_RS22420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THSYN_RS22425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THSYN_RS22435	COG0505	Belongs to the CarA family
THSYN_RS22440	COG2823	Periplasmic or secreted lipoprotein
THSYN_RS22440	COG1652	LysM domain
THSYN_RS22445	COG1444	tRNA N-acetyltransferase activity
THSYN_RS22485	COG4953	penicillin-binding protein 1C
THSYN_RS22510	COG0546	phosphoglycolate phosphatase activity
THSYN_RS22540	COG4133	protoheme IX ABC transporter activity
THSYN_RS22550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THSYN_RS22560	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
THSYN_RS22565	COG1138	Cytochrome C-type biogenesis protein
THSYN_RS22570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THSYN_RS22585	COG1881	PFAM PEBP family protein
THSYN_RS22590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THSYN_RS22600	COG0302	gtp cyclohydrolase
THSYN_RS22640	COG1797	cobyrinic acid a,c-diamide synthase activity
THSYN_RS22650	COG0437	4 iron, 4 sulfur cluster binding
THSYN_RS22675	COG2920	part of a sulfur-relay system
THSYN_RS22680	COG2168	tRNA wobble position uridine thiolation
THSYN_RS22685	COG2923	Belongs to the DsrF TusC family
THSYN_RS22690	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
THSYN_RS22695	COG2221	Nitrite and sulphite reductase 4Fe-4S
THSYN_RS22700	COG2221	Nitrite and sulphite reductase 4Fe-4S
THSYN_RS22720	COG2920	part of a sulfur-relay system
THSYN_RS22730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THSYN_RS22745	COG1216	Glycosyl transferase, family 2
THSYN_RS22745	COG1442	glycosyl transferase family 8
THSYN_RS22765	COG1215	transferase activity, transferring glycosyl groups
THSYN_RS22770	COG1216	Glycosyl transferase, family 2
THSYN_RS22775	COG0463	Glycosyl transferase, family 2
THSYN_RS22775	COG1216	Glycosyl transferase, family 2
THSYN_RS22785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THSYN_RS22800	COG1088	dTDP-glucose 4,6-dehydratase activity
THSYN_RS22810	COG3259	Nickel-dependent hydrogenase
THSYN_RS22815	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
THSYN_RS22820	COG3383	formate dehydrogenase (NAD+) activity
THSYN_RS22825	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THSYN_RS22835	COG0675	Transposase, IS605 OrfB family
THSYN_RS22845	COG1881	PFAM PEBP family protein
THSYN_RS22850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS22865	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THSYN_RS22875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THSYN_RS22880	COG0367	asparagine synthase
THSYN_RS22905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THSYN_RS22920	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
THSYN_RS22965	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
THSYN_RS22995	COG4974	Belongs to the 'phage' integrase family
THSYN_RS23025	COG2983	Belongs to the UPF0260 family
THSYN_RS23040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS23065	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
THSYN_RS23070	COG1396	sequence-specific DNA binding
THSYN_RS23085	COG0488	(ABC) transporter
THSYN_RS23100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THSYN_RS23110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THSYN_RS23115	COG1028	Short-chain dehydrogenase reductase Sdr
THSYN_RS23120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THSYN_RS23135	COG0463	Glycosyl transferase, family 2
THSYN_RS23150	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
THSYN_RS23165	COG0561	phosphatase activity
THSYN_RS23180	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
THSYN_RS23215	COG2337	Toxic component of a toxin-antitoxin (TA) module
THSYN_RS23225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THSYN_RS23245	COG2319	Wd-40 repeat
THSYN_RS23245	COG4249	Peptidase C14 caspase catalytic subunit p20
THSYN_RS23250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THSYN_RS23250	COG0519	Catalyzes the synthesis of GMP from XMP
THSYN_RS23275	COG1454	alcohol dehydrogenase
THSYN_RS23290	COG3119	arylsulfatase activity
THSYN_RS23300	COG3604	Transcriptional regulator
THSYN_RS23325	COG1570	exodeoxyribonuclease VII activity
THSYN_RS23370	COG2918	glutathione biosynthetic process
THSYN_RS23380	COG0242	peptide deformylase activity
THSYN_RS23385	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THSYN_RS23395	COG0564	pseudouridine synthase activity
THSYN_RS23410	COG3338	carbonate dehydratase activity
THSYN_RS23420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THSYN_RS23430	COG0321	lipoyl(octanoyl) transferase activity
THSYN_RS23445	COG1686	Belongs to the peptidase S11 family
THSYN_RS23455	COG0772	Belongs to the SEDS family
THSYN_RS23460	COG0768	penicillin binding
THSYN_RS23470	COG1792	Involved in formation and maintenance of cell shape
THSYN_RS23475	COG1077	Cell shape determining protein MreB Mrl
THSYN_RS23485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THSYN_RS23490	COG0154	amidase activity
THSYN_RS23515	COG1722	exodeoxyribonuclease VII activity
THSYN_RS23520	COG0142	geranyltranstransferase activity
THSYN_RS23530	COG2442	InterPro IPR007367
THSYN_RS23555	COG1106	Psort location Cytoplasmic, score
THSYN_RS23570	COG2197	response regulator
THSYN_RS23640	COG0297	glycogen (starch) synthase activity
THSYN_RS23640	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS23645	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS23675	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THSYN_RS23680	COG0724	RNA recognition motif
THSYN_RS23695	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
THSYN_RS23735	COG2358	TRAP transporter, solute receptor (TAXI family
THSYN_RS23740	COG0786	glutamate:sodium symporter activity
THSYN_RS23745	COG4636	protein conserved in cyanobacteria
THSYN_RS23770	COG1151	hydroxylamine reductase activity
THSYN_RS23785	COG0203	ribosomal protein L17
THSYN_RS23790	COG0202	RNA polymerase activity
THSYN_RS23795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THSYN_RS23800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THSYN_RS23805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THSYN_RS23810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THSYN_RS23815	COG0201	protein transport
THSYN_RS23820	COG0200	Binds to the 23S rRNA
THSYN_RS23825	COG1841	ribosomal large subunit assembly
THSYN_RS23830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THSYN_RS23835	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THSYN_RS23840	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THSYN_RS23845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THSYN_RS23850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THSYN_RS23855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THSYN_RS23860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THSYN_RS23865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THSYN_RS23870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THSYN_RS23875	COG0255	Belongs to the universal ribosomal protein uL29 family
THSYN_RS23880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THSYN_RS23885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THSYN_RS23890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THSYN_RS23895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THSYN_RS23900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THSYN_RS23905	COG0089	rRNA binding
THSYN_RS23910	COG0088	Forms part of the polypeptide exit tunnel
THSYN_RS23915	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THSYN_RS23920	COG0051	transcription antitermination factor activity, RNA binding
THSYN_RS23925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THSYN_RS23930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THSYN_RS23935	COG0049	tRNA binding
THSYN_RS23990	COG0776	regulation of translation
THSYN_RS23995	COG0072	phenylalanine-tRNA ligase activity
THSYN_RS23995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THSYN_RS24010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THSYN_RS24015	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THSYN_RS24020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THSYN_RS24040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THSYN_RS24045	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THSYN_RS24050	COG1381	Involved in DNA repair and RecF pathway recombination
THSYN_RS24075	COG0481	GTPase activity
THSYN_RS24080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THSYN_RS24085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THSYN_RS24090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THSYN_RS24100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THSYN_RS24140	COG1122	ATPase activity
THSYN_RS24170	COG2204	response regulator
THSYN_RS24180	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
THSYN_RS24190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THSYN_RS24195	COG0316	Belongs to the HesB IscA family
THSYN_RS24200	COG2166	iron-sulfur cluster assembly
THSYN_RS24225	COG2885	chlorophyll binding
THSYN_RS24225	COG3047	cAMP biosynthetic process
THSYN_RS24230	COG0457	Tetratricopeptide repeat
THSYN_RS24280	COG2197	response regulator
THSYN_RS24285	COG2201	protein-glutamate methylesterase activity
THSYN_RS24325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THSYN_RS24345	COG0489	protein tyrosine kinase activity
THSYN_RS24365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THSYN_RS24370	COG5265	(ABC) transporter
THSYN_RS24380	COG1064	alcohol dehydrogenase
THSYN_RS24385	COG1519	Transferase
THSYN_RS24390	COG0582	viral genome integration into host DNA
THSYN_RS24445	COG5566	PFAM Mor transcription activator
THSYN_RS24460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THSYN_RS24480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THSYN_RS24485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THSYN_RS24490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THSYN_RS24495	COG0142	geranyltranstransferase activity
THSYN_RS24525	COG0604	alcohol dehydrogenase
THSYN_RS24535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THSYN_RS24560	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
THSYN_RS24565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THSYN_RS24570	COG1007	ATP synthesis coupled electron transport
THSYN_RS24590	COG0713	ATP synthesis coupled electron transport
THSYN_RS24600	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THSYN_RS24605	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THSYN_RS24610	COG1034	ATP synthesis coupled electron transport
THSYN_RS24610	COG1034	ATP synthesis coupled electron transport
THSYN_RS24615	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THSYN_RS24620	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THSYN_RS24625	COG0649	NAD binding
THSYN_RS24630	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THSYN_RS24635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THSYN_RS24640	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THSYN_RS24655	COG0149	triose-phosphate isomerase activity
THSYN_RS24660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THSYN_RS24675	COG0038	chloride channel
THSYN_RS24695	COG2116	formate transmembrane transporter activity
THSYN_RS24710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS24770	COG2878	Part of a membrane complex involved in electron transport
THSYN_RS24775	COG4656	Part of a membrane complex involved in electron transport
THSYN_RS24780	COG2914	Belongs to the UPF0125 (RnfH) family
THSYN_RS24795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THSYN_RS24800	COG1663	tetraacyldisaccharide 4'-kinase activity
THSYN_RS24805	COG1132	(ABC) transporter
THSYN_RS24815	COG0811	peptide transport
THSYN_RS24830	COG0517	IMP dehydrogenase activity
THSYN_RS24835	COG4974	Belongs to the 'phage' integrase family
THSYN_RS24885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THSYN_RS24890	COG1758	RNA polymerase activity
THSYN_RS24895	COG0194	GDP metabolic process
THSYN_RS24900	COG1561	YicC-like family, N-terminal region
THSYN_RS24905	COG0515	serine threonine protein kinase
THSYN_RS24910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THSYN_RS24915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THSYN_RS24935	COG0280	phosphate acetyltransferase
THSYN_RS24945	COG2337	Toxic component of a toxin-antitoxin (TA) module
THSYN_RS24965	COG3300	MHYT domain
THSYN_RS24965	COG5001	Diguanylate cyclase
THSYN_RS25005	COG1063	alcohol dehydrogenase
THSYN_RS25040	COG1434	Gram-negative-bacterium-type cell wall biogenesis
THSYN_RS25045	COG2226	methyltransferase
THSYN_RS25050	COG0367	asparagine synthase
THSYN_RS25060	COG2226	methyltransferase
THSYN_RS25085	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS25120	COG0463	Glycosyl transferase, family 2
THSYN_RS25120	COG1216	Glycosyl transferase, family 2
THSYN_RS25135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THSYN_RS25155	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS25190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THSYN_RS25270	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
THSYN_RS25275	COG1051	belongs to the nudix hydrolase family
THSYN_RS25425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THSYN_RS25470	COG0489	protein tyrosine kinase activity
THSYN_RS25495	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THSYN_RS25510	COG0730	response to heat
THSYN_RS25585	COG4771	TonB-dependent receptor
THSYN_RS25615	COG0300	oxidoreductase activity
THSYN_RS25630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THSYN_RS25645	COG3122	Protein conserved in bacteria
THSYN_RS25655	COG0084	hydrolase, TatD family'
THSYN_RS25670	COG0420	3'-5' exonuclease activity
THSYN_RS25765	COG1560	Kdo2-lipid A biosynthetic process
THSYN_RS25785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THSYN_RS25800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THSYN_RS25810	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THSYN_RS25845	COG3243	poly(R)-hydroxyalkanoic acid synthase
THSYN_RS25855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THSYN_RS25860	COG2027	D-alanyl-D-alanine carboxypeptidase
THSYN_RS25870	COG2205	protein histidine kinase activity
THSYN_RS25875	COG0745	RESPONSE REGULATOR receiver
THSYN_RS25880	COG3706	GGDEF domain
THSYN_RS25885	COG3706	GGDEF domain
THSYN_RS25900	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THSYN_RS25910	COG0028	Belongs to the TPP enzyme family
THSYN_RS25920	COG0442	prolyl-tRNA aminoacylation
THSYN_RS25925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THSYN_RS25950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
THSYN_RS25955	COG1254	Belongs to the acylphosphatase family
THSYN_RS25965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THSYN_RS25970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THSYN_RS25975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THSYN_RS25980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THSYN_RS25995	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THSYN_RS26000	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THSYN_RS26005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
THSYN_RS26035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THSYN_RS26060	COG0484	heat shock protein binding
THSYN_RS26065	COG0443	Heat shock 70 kDa protein
THSYN_RS26070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THSYN_RS26075	COG1420	regulation of RNA biosynthetic process
THSYN_RS26080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THSYN_RS26085	COG0497	DNA recombination
THSYN_RS26100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS26105	COG1943	Transposase
THSYN_RS26110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS26115	COG0735	belongs to the Fur family
THSYN_RS26120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THSYN_RS26125	COG2867	negative regulation of translational initiation
THSYN_RS26130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THSYN_RS26135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THSYN_RS26145	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THSYN_RS26160	COG0791	NLP P60 protein
THSYN_RS26165	COG0492	ferredoxin-NADP+ reductase activity
THSYN_RS26195	COG1696	Membrane protein involved in D-alanine export
THSYN_RS26225	COG1966	Carbon starvation protein
THSYN_RS26230	COG2879	small protein
THSYN_RS26265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THSYN_RS26270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
THSYN_RS26285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THSYN_RS26370	COG2267	carboxylic ester hydrolase activity
THSYN_RS26405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THSYN_RS26410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THSYN_RS26425	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
THSYN_RS26435	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THSYN_RS26445	COG1765	OsmC-like protein
THSYN_RS26450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THSYN_RS26470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THSYN_RS26490	COG1607	acyl-coa hydrolase
THSYN_RS26525	COG0367	asparagine synthase
THSYN_RS26555	COG0443	Heat shock 70 kDa protein
THSYN_RS26560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
THSYN_RS26570	COG0822	iron-sulfur transferase activity
THSYN_RS26575	COG1104	cysteine desulfurase activity
THSYN_RS26590	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
THSYN_RS26610	COG1643	Atp-dependent helicase
THSYN_RS26625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THSYN_RS26670	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THSYN_RS26675	COG0598	Magnesium transport protein CorA
THSYN_RS26700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THSYN_RS26705	COG1295	ribonuclease BN
THSYN_RS26710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THSYN_RS26715	COG1720	tRNA m6t6A37 methyltransferase activity
THSYN_RS26730	COG0784	Response regulator, receiver
THSYN_RS26730	COG2205	protein histidine kinase activity
THSYN_RS26730	COG5002	protein histidine kinase activity
THSYN_RS26735	COG0318	PFAM AMP-dependent synthetase and ligase
THSYN_RS26735	COG0204	Acyl-transferase
THSYN_RS26755	COG5001	Diguanylate cyclase
THSYN_RS26755	COG3706	GGDEF domain
THSYN_RS26755	COG2203	Gaf domain
THSYN_RS26755	COG4251	negative regulation of phosphorylation
THSYN_RS26795	COG1216	Glycosyl transferase, family 2
THSYN_RS26815	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
THSYN_RS26825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THSYN_RS26840	COG1216	Glycosyl transferase, family 2
THSYN_RS26865	COG1217	gtp-binding protein TYPA
THSYN_RS26880	COG0737	Belongs to the 5'-nucleotidase family
THSYN_RS26890	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
THSYN_RS26900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THSYN_RS26910	COG1895	HEPN domain
THSYN_RS26920	COG1942	4-Oxalocrotonate Tautomerase
THSYN_RS26925	COG3647	Membrane
THSYN_RS26950	COG2878	Part of a membrane complex involved in electron transport
THSYN_RS26955	COG4656	Part of a membrane complex involved in electron transport
THSYN_RS26965	COG4659	FMN binding
THSYN_RS27000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS27010	COG1376	ErfK ybiS ycfS ynhG family protein
THSYN_RS27020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
THSYN_RS27050	COG4636	protein conserved in cyanobacteria
THSYN_RS27135	COG0045	succinate-CoA ligase (ADP-forming) activity
THSYN_RS27135	COG1042	CoA-binding domain protein
THSYN_RS27135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THSYN_RS27140	COG0123	including yeast histone deacetylase and acetoin utilization protein
THSYN_RS27145	COG2205	protein histidine kinase activity
THSYN_RS27145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THSYN_RS27155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THSYN_RS27155	COG2205	protein histidine kinase activity
THSYN_RS27160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THSYN_RS27160	COG2205	protein histidine kinase activity
THSYN_RS27180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THSYN_RS27180	COG0189	ligase activity
THSYN_RS27185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THSYN_RS27185	COG0189	ligase activity
THSYN_RS27210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS27220	COG1132	(ABC) transporter
THSYN_RS27290	COG2925	Exonuclease
THSYN_RS27295	COG0335	large ribosomal subunit rRNA binding
THSYN_RS27300	COG0336	Belongs to the RNA methyltransferase TrmD family
THSYN_RS27305	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THSYN_RS27310	COG0228	four-way junction DNA binding
THSYN_RS27335	COG1196	nuclear chromosome segregation
THSYN_RS27375	COG5002	protein histidine kinase activity
THSYN_RS27375	COG0784	Response regulator, receiver
THSYN_RS27375	COG2205	protein histidine kinase activity
THSYN_RS27510	COG5012	cobalamin binding
THSYN_RS27520	COG3276	selenocysteine insertion sequence binding
THSYN_RS27555	COG2864	formate dehydrogenase
THSYN_RS27560	COG0437	4 iron, 4 sulfur cluster binding
THSYN_RS27570	COG0243	molybdopterin cofactor binding
THSYN_RS27570	COG3383	formate dehydrogenase (NAD+) activity
THSYN_RS27615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS27625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THSYN_RS27630	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THSYN_RS27640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THSYN_RS27650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THSYN_RS27655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THSYN_RS27660	COG0193	aminoacyl-tRNA hydrolase activity
THSYN_RS27670	COG0513	Belongs to the DEAD box helicase family
THSYN_RS27675	COG4974	Belongs to the 'phage' integrase family
THSYN_RS27680	COG0517	IMP dehydrogenase activity
THSYN_RS27770	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
THSYN_RS27775	COG1121	(ABC) transporter
THSYN_RS27780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THSYN_RS27785	COG0735	belongs to the Fur family
THSYN_RS27790	COG0596	Alpha beta hydrolase
THSYN_RS27795	COG1490	D-aminoacyl-tRNA deacylase activity
THSYN_RS27810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THSYN_RS27815	COG0730	response to heat
THSYN_RS27855	COG4953	penicillin-binding protein 1C
THSYN_RS27860	COG2373	Large extracellular alpha-helical protein
THSYN_RS27865	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THSYN_RS27870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
THSYN_RS27885	COG4636	protein conserved in cyanobacteria
THSYN_RS27910	COG3629	intracellular signal transduction
THSYN_RS27910	COG3903	Transcriptional regulator
THSYN_RS27920	COG0714	Associated with various cellular activities
THSYN_RS27955	COG1376	ErfK ybiS ycfS ynhG family protein
THSYN_RS27960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THSYN_RS27965	COG2814	Major facilitator Superfamily
THSYN_RS28005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THSYN_RS28020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THSYN_RS28065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THSYN_RS28075	COG3162	membrane
THSYN_RS28080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THSYN_RS28090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THSYN_RS28115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THSYN_RS28140	COG0237	dephospho-CoA kinase activity
THSYN_RS28145	COG0028	Belongs to the TPP enzyme family
THSYN_RS28160	COG1328	CTP reductase activity
THSYN_RS28160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THSYN_RS28190	COG0587	DNA-directed DNA polymerase activity
THSYN_RS28200	COG0616	signal peptide processing
THSYN_RS28205	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
THSYN_RS28210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THSYN_RS28215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THSYN_RS28220	COG1309	transcriptional regulator
THSYN_RS28235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THSYN_RS28250	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
THSYN_RS28255	COG0495	leucyl-tRNA aminoacylation
THSYN_RS28260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THSYN_RS28315	COG2181	nitrate reductase activity
THSYN_RS28330	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THSYN_RS28335	COG0298	carbon dioxide binding
THSYN_RS28375	COG1469	GTP cyclohydrolase I activity
THSYN_RS28395	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
THSYN_RS28400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THSYN_RS28420	COG0513	Belongs to the DEAD box helicase family
THSYN_RS28425	COG0688	phosphatidylethanolamine metabolic process
THSYN_RS28430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THSYN_RS28435	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
THSYN_RS28445	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
THSYN_RS28450	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THSYN_RS28500	COG2050	protein possibly involved in aromatic compounds catabolism
THSYN_RS28505	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THSYN_RS28510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THSYN_RS28520	COG5433	transposase activity
THSYN_RS28545	COG1477	protein flavinylation
THSYN_RS28550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THSYN_RS28555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THSYN_RS28560	COG1862	Preprotein translocase
THSYN_RS28565	COG0343	queuine tRNA-ribosyltransferase activity
THSYN_RS28575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THSYN_RS28590	COG3344	reverse transcriptase
THSYN_RS28605	COG2161	toxin-antitoxin pair type II binding
THSYN_RS28665	COG0567	Dehydrogenase, E1 component
THSYN_RS28690	COG0363	glucosamine-6-phosphate deaminase activity
THSYN_RS28700	COG0745	RESPONSE REGULATOR receiver
THSYN_RS28705	COG2205	protein histidine kinase activity
THSYN_RS28750	COG0314	molybdopterin synthase activity
THSYN_RS28770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THSYN_RS28780	COG3956	TIGRFAM MazG family protein
THSYN_RS28795	COG2135	peptidase activity
THSYN_RS28825	COG1397	ADP-ribosylglycohydrolase
THSYN_RS28830	COG3030	protein affecting phage T7 exclusion by the F plasmid
THSYN_RS28835	COG1324	tolerance protein
THSYN_RS28840	COG4232	protein-disulfide reductase activity
THSYN_RS28845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THSYN_RS28850	COG0511	ligase activity, forming carbon-carbon bonds
THSYN_RS28855	COG0439	Biotin carboxylase
THSYN_RS28865	COG0514	ATP-dependent DNA helicase (RecQ)
THSYN_RS28910	COG0494	nUDIX hydrolase
THSYN_RS28915	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
THSYN_RS28945	COG0375	protein maturation
THSYN_RS28970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THSYN_RS28985	COG0367	asparagine synthase
THSYN_RS29005	COG0463	Glycosyl transferase, family 2
THSYN_RS29030	COG1215	transferase activity, transferring glycosyl groups
THSYN_RS29040	COG1091	dTDP-4-dehydrorhamnose reductase activity
THSYN_RS29075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THSYN_RS29100	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THSYN_RS29110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THSYN_RS29115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THSYN_RS29150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THSYN_RS29155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THSYN_RS29165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THSYN_RS29170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THSYN_RS29175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THSYN_RS29185	COG0356	it plays a direct role in the translocation of protons across the membrane
THSYN_RS29195	COG1475	DNA binding
THSYN_RS29200	COG1192	Involved in chromosome partitioning
THSYN_RS29205	COG0357	Ribosomal RNA small subunit methyltransferase G
THSYN_RS29210	COG3119	arylsulfatase activity
THSYN_RS29255	COG0445	tRNA wobble uridine modification
THSYN_RS29260	COG0714	Associated with various cellular activities
THSYN_RS29275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THSYN_RS29280	COG0706	membrane insertase activity
THSYN_RS29285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THSYN_RS29290	COG0594	ribonuclease P activity
THSYN_RS29295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THSYN_RS29315	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
THSYN_RS29335	COG2843	Capsule synthesis protein
THSYN_RS29355	COG1238	metal cluster binding
THSYN_RS29455	COG4251	negative regulation of phosphorylation
THSYN_RS29460	COG0784	Response regulator, receiver
THSYN_RS29480	COG5012	cobalamin binding
THSYN_RS29505	COG0583	DNA-binding transcription factor activity
THSYN_RS29510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THSYN_RS29515	COG3002	Belongs to the UPF0753 family
THSYN_RS29655	COG3436	PFAM IS66 Orf2 family protein
THSYN_RS29685	COG0776	regulation of translation
THSYN_RS29705	COG1850	ribulose-bisphosphate carboxylase activity
THSYN_RS29710	COG4451	ribulose bisphosphate carboxylase, small
THSYN_RS29735	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THSYN_RS29740	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THSYN_RS29760	COG0583	DNA-binding transcription factor activity
THSYN_RS29765	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THSYN_RS29775	COG4585	Histidine kinase
THSYN_RS29800	COG1704	LemA family
THSYN_RS29805	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
THSYN_RS29815	COG0662	Cupin 2, conserved barrel domain protein
THSYN_RS29830	COG1984	allophanate hydrolase subunit 2
THSYN_RS29835	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
THSYN_RS29840	COG4636	protein conserved in cyanobacteria
THSYN_RS29870	COG0857	belongs to the CobB CobQ family
THSYN_RS29870	COG0280	phosphate acetyltransferase
THSYN_RS29895	COG0776	regulation of translation
THSYN_RS30015	COG1231	oxidoreductase activity
THSYN_RS30020	COG0776	regulation of translation
THSYN_RS30035	COG3620	sequence-specific DNA binding
THSYN_RS30060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THSYN_RS30100	COG0187	DNA topoisomerase II activity
THSYN_RS30105	COG0557	exoribonuclease II activity
THSYN_RS30145	COG1475	DNA binding
THSYN_RS30210	COG3385	transposase activity
THSYN_RS30240	COG4383	Mu-like prophage protein gp29
THSYN_RS30255	COG2369	cell adhesion
THSYN_RS30280	COG3385	transposase activity
THSYN_RS30415	COG0745	RESPONSE REGULATOR receiver
THSYN_RS30485	COG1196	nuclear chromosome segregation
THSYN_RS30485	COG0741	lytic transglycosylase activity
THSYN_RS30485	COG0739	heme binding
THSYN_RS30525	COG3436	PFAM IS66 Orf2 family protein
THSYN_RS30560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THSYN_RS30560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THSYN_RS30575	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS30600	COG2233	PERMEase
THSYN_RS30605	COG2233	PERMEase
THSYN_RS30635	COG1366	Belongs to the anti-sigma-factor antagonist family
THSYN_RS30645	COG2208	phosphoserine phosphatase activity
THSYN_RS30715	COG4716	Myosin-crossreactive antigen
THSYN_RS30720	COG4716	Myosin-crossreactive antigen
THSYN_RS30725	COG4279	zinc finger
THSYN_RS30730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS30765	COG1238	metal cluster binding
THSYN_RS30775	COG3541	Predicted nucleotidyltransferase
THSYN_RS30785	COG1201	RNA secondary structure unwinding
THSYN_RS30840	COG2337	Toxic component of a toxin-antitoxin (TA) module
THSYN_RS30875	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
THSYN_RS30880	COG3220	belongs to the UPF0276 family
THSYN_RS30895	COG1595	DNA-templated transcription, initiation
THSYN_RS30935	COG2326	polyphosphate kinase activity
THSYN_RS30945	COG0586	Pfam SNARE associated Golgi protein
THSYN_RS30965	COG0598	Magnesium transport protein CorA
THSYN_RS30975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THSYN_RS30995	COG1945	arginine decarboxylase activity
THSYN_RS31010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THSYN_RS31015	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
THSYN_RS31045	COG0704	Plays a role in the regulation of phosphate uptake
THSYN_RS31065	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
THSYN_RS31080	COG0573	inorganic phosphate transmembrane transporter activity
THSYN_RS31085	COG0581	inorganic phosphate transmembrane transporter activity
THSYN_RS31090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THSYN_RS31120	COG1272	protein, Hemolysin III
THSYN_RS31165	COG0438	transferase activity, transferring glycosyl groups
THSYN_RS31185	COG1475	DNA binding
THSYN_RS31190	COG1192	Involved in chromosome partitioning
THSYN_RS31210	COG1278	Cold shock
THSYN_RS31220	COG1388	LysM domain
THSYN_RS31220	COG3942	CHAP domain
THSYN_RS31230	COG3038	cytochrome b561
THSYN_RS31235	COG1160	GTP binding
THSYN_RS31275	COG0500	methyltransferase
THSYN_RS31280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THSYN_RS31305	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
THSYN_RS31335	COG2814	Major facilitator Superfamily
THSYN_RS31340	COG0142	geranyltranstransferase activity
THSYN_RS31345	COG1063	alcohol dehydrogenase
THSYN_RS31350	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THSYN_RS31355	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THSYN_RS31360	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THSYN_RS31405	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
THSYN_RS31415	COG1850	ribulose-bisphosphate carboxylase activity
THSYN_RS31420	COG1562	ergosterol biosynthetic process
THSYN_RS31425	COG1233	COG1233 Phytoene dehydrogenase and related
THSYN_RS31455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
THSYN_RS31460	COG2442	InterPro IPR007367
THSYN_RS31465	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THSYN_RS31475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THSYN_RS31490	COG2326	polyphosphate kinase activity
THSYN_RS31540	COG1136	(ABC) transporter
THSYN_RS31595	COG0517	IMP dehydrogenase activity
THSYN_RS31600	COG4974	Belongs to the 'phage' integrase family
THSYN_RS31640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THSYN_RS31670	COG2814	Major facilitator Superfamily
THSYN_RS31680	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THSYN_RS31685	COG1429	ligase activity, forming nitrogen-metal bonds
THSYN_RS31695	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THSYN_RS31715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THSYN_RS31760	COG4942	peptidase
THSYN_RS31800	COG4453	Protein conserved in bacteria
THSYN_RS31805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THSYN_RS31810	COG2211	Major facilitator Superfamily
THSYN_RS31815	COG0644	oxidoreductase
THSYN_RS31830	COG1229	Formylmethanofuran dehydrogenase subunit A
THSYN_RS31835	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
THSYN_RS31855	COG2133	pyrroloquinoline quinone binding
THSYN_RS31865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THSYN_RS31870	COG3158	transport of potassium into the cell
THSYN_RS31875	COG0537	adenosine 5'-monophosphoramidase activity
THSYN_RS31890	COG3609	addiction module antidote protein, CC2985 family
THSYN_RS31955	COG0746	molybdenum cofactor guanylyltransferase activity
THSYN_RS31960	COG2154	pterin-4-alpha-carbinolamine dehydratase
THSYN_RS31965	COG4628	conserved protein (DUF2132)
THSYN_RS31985	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
THSYN_RS32020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THSYN_RS32025	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
THSYN_RS32040	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
THSYN_RS32045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THSYN_RS32050	COG0702	epimerase
THSYN_RS32105	COG1690	Belongs to the RtcB family
THSYN_RS32125	COG2885	chlorophyll binding
THSYN_RS32135	COG0175	sulfate reduction
THSYN_RS32145	COG1122	ATPase activity
THSYN_RS32150	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THSYN_RS32180	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
THSYN_RS32280	COG0793	Belongs to the peptidase S41A family
THSYN_RS32280	COG4946	Tricorn protease homolog
THSYN_RS32285	COG1840	ABC-type Fe3 transport system, periplasmic component
THSYN_RS32290	COG1176	ABC-type spermidine putrescine transport system, permease component I
THSYN_RS32295	COG3842	ATPase activity
THSYN_RS32315	COG0778	Nitroreductase
THSYN_RS32330	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THSYN_RS32375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THSYN_RS32435	COG1492	cobalamin metabolic process
THSYN_RS32440	COG3177	Filamentation induced by cAMP protein fic
THSYN_RS32455	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
THSYN_RS32460	COG2267	carboxylic ester hydrolase activity
THSYN_RS32480	COG0702	epimerase
THSYN_RS32510	COG4974	Belongs to the 'phage' integrase family
THSYN_RS32515	COG0517	IMP dehydrogenase activity
THSYN_RS32530	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
THSYN_RS32545	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
THSYN_RS32585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THSYN_RS32590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THSYN_RS32610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THSYN_RS32635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
THSYN_RS32650	COG0535	radical SAM domain protein
THSYN_RS32735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS32745	COG1716	ATPase activity
THSYN_RS32765	COG0443	Heat shock 70 kDa protein
THSYN_RS32780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THSYN_RS32865	COG0456	acetyltransferase
THSYN_RS32950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THSYN_RS32965	COG0517	IMP dehydrogenase activity
THSYN_RS32970	COG4974	Belongs to the 'phage' integrase family
THSYN_RS32990	COG1131	(ABC) transporter
THSYN_RS33080	COG0582	viral genome integration into host DNA
THSYN_RS33085	COG0582	viral genome integration into host DNA
THSYN_RS33090	COG4974	Belongs to the 'phage' integrase family
THSYN_RS33105	COG0602	queuosine metabolic process
THSYN_RS33110	COG0483	inositol monophosphate 1-phosphatase activity
THSYN_RS33150	COG3284	Transcriptional regulator
THSYN_RS33180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
THSYN_RS33185	COG3383	formate dehydrogenase (NAD+) activity
THSYN_RS33240	COG5433	transposase activity