locus-tag	class	description
W908_RS00020	COG0149	triose-phosphate isomerase activity
W908_RS00045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
W908_RS00050	COG0052	Belongs to the universal ribosomal protein uS2 family
W908_RS00065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
W908_RS00085	COG0735	belongs to the Fur family
W908_RS00110	COG1960	acyl-CoA dehydrogenase activity
W908_RS00120	COG1250	3-hydroxyacyl-CoA dehydrogenase
W908_RS00120	COG1024	Enoyl-CoA hydratase
W908_RS00130	COG2873	o-acetylhomoserine
W908_RS00135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
W908_RS00140	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
W908_RS00150	COG0193	aminoacyl-tRNA hydrolase activity
W908_RS00155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
W908_RS00160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
W908_RS00170	COG2226	methyltransferase
W908_RS00180	COG0316	Belongs to the HesB IscA family
W908_RS00185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
W908_RS00190	COG0439	Biotin carboxylase
W908_RS00195	COG0511	ligase activity, forming carbon-carbon bonds
W908_RS00205	COG0697	spore germination
W908_RS00215	COG1012	belongs to the aldehyde dehydrogenase family
W908_RS00220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
W908_RS00230	COG2267	carboxylic ester hydrolase activity
W908_RS00245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
W908_RS00250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
W908_RS00255	COG0497	DNA recombination
W908_RS00265	COG0356	it plays a direct role in the translocation of protons across the membrane
W908_RS00275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
W908_RS00280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
W908_RS00285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
W908_RS00290	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
W908_RS00295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
W908_RS00300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
W908_RS00310	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
W908_RS00315	COG0706	membrane insertase activity
W908_RS00320	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
W908_RS00325	COG0594	ribonuclease P activity
W908_RS00330	COG2922	Belongs to the Smg family
W908_RS00340	COG0135	phosphoribosylanthranilate isomerase activity
W908_RS00345	COG0133	tryptophan synthase activity
W908_RS00365	COG5598	trimethylamine methyltransferase
W908_RS00370	COG0824	Thioesterase
W908_RS00370	COG1250	3-hydroxyacyl-CoA dehydrogenase
W908_RS00375	COG3246	L-lysine catabolic process to acetate
W908_RS00380	COG3842	ATPase activity
W908_RS00390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
W908_RS00400	COG1028	Short-chain dehydrogenase reductase Sdr
W908_RS00405	COG1609	Transcriptional regulator
W908_RS00425	COG0596	Alpha beta hydrolase
W908_RS00445	COG1175	transmembrane transport
W908_RS00450	COG0395	ABC-type sugar transport system, permease component
W908_RS00475	COG0006	proline dipeptidase activity
W908_RS00485	COG0604	alcohol dehydrogenase
W908_RS00485	COG1028	Short-chain dehydrogenase reductase Sdr
W908_RS00485	COG3321	synthase
W908_RS00500	COG1012	belongs to the aldehyde dehydrogenase family
W908_RS00505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
W908_RS00510	COG1028	Short-chain dehydrogenase reductase Sdr
W908_RS00515	COG1028	Short-chain dehydrogenase reductase Sdr
W908_RS00520	COG5598	trimethylamine methyltransferase
W908_RS00525	COG1012	belongs to the aldehyde dehydrogenase family
W908_RS00545	COG1760	l-serine dehydratase
W908_RS00550	COG2895	sulfate adenylyltransferase (ATP) activity
W908_RS00550	COG0529	Catalyzes the synthesis of activated sulfate
W908_RS00560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
W908_RS00565	COG0509	glycine decarboxylation via glycine cleavage system
W908_RS00570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
W908_RS00570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
W908_RS00610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
W908_RS00640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
W908_RS00645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
W908_RS00650	COG0352	thiamine-phosphate diphosphorylase activity
W908_RS00665	COG0563	adenylate kinase activity
W908_RS00670	COG0205	6-phosphofructokinase activity
W908_RS00675	COG2084	Dehydrogenase
W908_RS00680	COG1011	Hydrolase
W908_RS00685	COG0215	cysteine-tRNA ligase activity
W908_RS00690	COG1773	rubredoxin
W908_RS00695	COG0473	3-isopropylmalate dehydrogenase activity
W908_RS00705	COG2084	Dehydrogenase
W908_RS00715	COG0494	nUDIX hydrolase
W908_RS00720	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
W908_RS00725	COG0019	diaminopimelate decarboxylase activity
W908_RS00735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
W908_RS00745	COG1218	3'(2'),5'-bisphosphate nucleotidase
W908_RS00750	COG3340	Belongs to the peptidase S51 family
W908_RS00760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
W908_RS00765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
W908_RS00770	COG0386	Belongs to the glutathione peroxidase family
W908_RS00780	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
W908_RS00785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
W908_RS00790	COG0006	proline dipeptidase activity
W908_RS00795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
W908_RS00805	COG0546	phosphoglycolate phosphatase activity
W908_RS00810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
W908_RS00815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
W908_RS00820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
W908_RS00825	COG0583	DNA-binding transcription factor activity
W908_RS00830	COG1592	Rubrerythrin
W908_RS00845	COG0037	tRNA processing
W908_RS00850	COG0825	malonyl-CoA metabolic process
W908_RS00855	COG1280	lysine exporter protein (LysE YggA)
W908_RS00870	COG1414	Transcriptional regulator
W908_RS00880	COG0596	Alpha beta hydrolase
W908_RS00895	COG1176	ABC-type spermidine putrescine transport system, permease component I
W908_RS00900	COG1177	transmembrane transport
W908_RS00930	COG1012	belongs to the aldehyde dehydrogenase family
W908_RS00935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
W908_RS00940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
W908_RS00970	COG1172	Belongs to the binding-protein-dependent transport system permease family
W908_RS00975	COG1129	ABC transporter
W908_RS00980	COG0673	inositol 2-dehydrogenase activity
W908_RS00990	COG3718	enzyme involved in inositol metabolism
W908_RS00995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
W908_RS01000	COG3962	Belongs to the TPP enzyme family
W908_RS01015	COG0673	inositol 2-dehydrogenase activity
W908_RS01020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
W908_RS01025	COG3718	enzyme involved in inositol metabolism
W908_RS01035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
W908_RS01055	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
W908_RS01075	COG1063	alcohol dehydrogenase
W908_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
W908_RS01085	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
W908_RS01090	COG2721	sulfolactate sulfo-lyase activity
W908_RS01095	COG2721	sulfolactate sulfo-lyase activity
W908_RS01115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
W908_RS01125	COG2081	HI0933 family
W908_RS01135	COG2855	membrane
W908_RS01145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
W908_RS01150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
W908_RS01165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
W908_RS01170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
W908_RS01180	COG1522	sequence-specific DNA binding
W908_RS01185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
W908_RS01200	COG2878	Part of a membrane complex involved in electron transport
W908_RS01205	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
W908_RS01210	COG0738	Major facilitator superfamily
W908_RS01220	COG0045	succinate-CoA ligase (ADP-forming) activity
W908_RS01225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
W908_RS01230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
W908_RS01235	COG2983	Belongs to the UPF0260 family
W908_RS01245	COG0137	argininosuccinate synthase activity
W908_RS01280	COG2046	Belongs to the sulfate adenylyltransferase family
W908_RS01285	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
W908_RS01290	COG1687	branched-chain amino acid
W908_RS01295	COG0659	secondary active sulfate transmembrane transporter activity
W908_RS01320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
W908_RS01325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
W908_RS01335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
W908_RS01340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
W908_RS01345	COG0049	tRNA binding
W908_RS01350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
W908_RS01355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
W908_RS01360	COG0051	transcription antitermination factor activity, RNA binding
W908_RS01365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
W908_RS01370	COG0088	Forms part of the polypeptide exit tunnel
W908_RS01375	COG0089	rRNA binding
W908_RS01380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
W908_RS01385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
W908_RS01390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
W908_RS01395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
W908_RS01400	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
W908_RS01405	COG0255	Belongs to the universal ribosomal protein uL29 family
W908_RS01410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
W908_RS01415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
W908_RS01420	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
W908_RS01425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
W908_RS01430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
W908_RS01435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
W908_RS01440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
W908_RS01445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
W908_RS01450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
W908_RS01455	COG1841	ribosomal large subunit assembly
W908_RS01460	COG0200	Binds to the 23S rRNA
W908_RS01470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
W908_RS01475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
W908_RS01480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
W908_RS01485	COG0202	RNA polymerase activity
W908_RS01490	COG0203	ribosomal protein L17
W908_RS01495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
W908_RS01500	COG1610	YqeY-like protein
W908_RS01505	COG1522	sequence-specific DNA binding
W908_RS01525	COG1024	Enoyl-CoA hydratase
W908_RS01525	COG1250	3-hydroxyacyl-CoA dehydrogenase
W908_RS01530	COG0183	Belongs to the thiolase family
W908_RS01535	COG2070	2-Nitropropane dioxygenase
W908_RS01545	COG0318	PFAM AMP-dependent synthetase and ligase
W908_RS01555	COG1435	thymidine kinase activity
W908_RS01560	COG0730	response to heat
W908_RS01565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
W908_RS01580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
W908_RS01585	COG0824	Thioesterase
W908_RS01585	COG1250	3-hydroxyacyl-CoA dehydrogenase
W908_RS01590	COG1960	acyl-CoA dehydrogenase activity
W908_RS01595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
W908_RS01595	COG1042	CoA-binding domain protein
W908_RS01595	COG0045	succinate-CoA ligase (ADP-forming) activity
W908_RS01600	COG1024	Enoyl-CoA hydratase
W908_RS01615	COG1028	Short-chain dehydrogenase reductase Sdr
W908_RS01620	COG4175	Glycine betaine
W908_RS01620	COG3448	diguanylate cyclase activity
W908_RS01625	COG4176	ABC-type proline glycine betaine transport system permease component
W908_RS01640	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
W908_RS01645	COG4948	Mandelate Racemase Muconate Lactonizing
W908_RS01650	COG0544	peptidyl-prolyl cis-trans isomerase activity
W908_RS01655	COG0740	serine-type endopeptidase activity
W908_RS01665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
W908_RS01670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
W908_RS01675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
W908_RS01675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
W908_RS01680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
W908_RS01685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
W908_RS01695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
W908_RS01700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
W908_RS01705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
W908_RS01715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
W908_RS01720	COG1611	Belongs to the LOG family
W908_RS01730	COG2210	Belongs to the sulfur carrier protein TusA family
W908_RS01755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
W908_RS01760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
W908_RS01765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
W908_RS01770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
W908_RS01775	COG0543	2 iron, 2 sulfur cluster binding
W908_RS01780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
W908_RS01785	COG0252	asparaginase activity
W908_RS01805	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
W908_RS01810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
W908_RS01815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
W908_RS01830	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
W908_RS01835	COG1034	ATP synthesis coupled electron transport
W908_RS01840	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
W908_RS01845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
W908_RS01855	COG0713	ATP synthesis coupled electron transport
W908_RS01870	COG1007	ATP synthesis coupled electron transport
W908_RS01875	COG0584	glycerophosphoryl diester phosphodiesterase
W908_RS01885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
W908_RS01890	COG1929	Belongs to the glycerate kinase type-1 family
W908_RS01895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
W908_RS01905	COG4638	Rieske (2fe-2S)
W908_RS01910	COG0346	lactoylglutathione lyase activity
W908_RS01920	COG1522	sequence-specific DNA binding
W908_RS01925	COG0174	glutamine synthetase
W908_RS01930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
W908_RS01935	COG2218	PFAM glutamate synthase alpha subunit domain protein
W908_RS01940	COG0069	glutamate synthase activity
W908_RS01955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
W908_RS01965	COG1131	(ABC) transporter
W908_RS01970	COG0842	Transport permease protein
W908_RS01980	COG2226	methyltransferase
W908_RS01985	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
W908_RS01990	COG0500	methyltransferase
W908_RS02005	COG0233	cytoplasmic translational termination
W908_RS02010	COG0528	UMP kinase activity
W908_RS02015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
W908_RS02025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
W908_RS02030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
W908_RS02035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
W908_RS02040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
W908_RS02045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
W908_RS02045	COG1648	precorrin-2 dehydrogenase activity
W908_RS02055	COG1309	transcriptional regulator
W908_RS02070	COG1138	Cytochrome C-type biogenesis protein
W908_RS02080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
W908_RS02085	COG0336	Belongs to the RNA methyltransferase TrmD family
W908_RS02090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
W908_RS02100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
W908_RS02110	COG0004	ammonium transporteR
W908_RS02115	COG3707	response regulator
W908_RS02120	COG0140	phosphoribosyl-ATP diphosphatase activity
W908_RS02125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
W908_RS02135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
W908_RS02140	COG1560	Kdo2-lipid A biosynthetic process
W908_RS02160	COG0275	rRNA processing
W908_RS02165	COG2001	Belongs to the MraZ family
W908_RS02185	COG1053	succinate dehydrogenase
W908_RS02190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
W908_RS02195	COG0039	L-malate dehydrogenase activity
W908_RS02200	COG0281	malic enzyme
W908_RS02220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
W908_RS02230	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
W908_RS02240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
W908_RS02245	COG0081	regulation of translation
W908_RS02250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
W908_RS02255	COG0222	ribosome binding
W908_RS02260	COG0085	RNA polymerase activity
W908_RS02265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
W908_RS02270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
W908_RS02275	COG0587	DNA-directed DNA polymerase activity
W908_RS02285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
W908_RS02285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
W908_RS02290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
W908_RS02295	COG2137	regulation of response to DNA damage stimulus
W908_RS02300	COG0343	queuine tRNA-ribosyltransferase activity
W908_RS02305	COG0768	penicillin binding
W908_RS02315	COG1792	Involved in formation and maintenance of cell shape
W908_RS02320	COG1077	Cell shape determining protein MreB Mrl
W908_RS02325	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
W908_RS02325	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
W908_RS02350	COG1522	sequence-specific DNA binding
W908_RS02355	COG0006	proline dipeptidase activity
W908_RS02370	COG2890	protein-(glutamine-N5) methyltransferase activity
W908_RS02375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
W908_RS02380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
W908_RS02385	COG0165	Argininosuccinate lyase
W908_RS02390	COG0181	hydroxymethylbilane synthase activity
W908_RS02395	COG2154	pterin-4-alpha-carbinolamine dehydratase
W908_RS02400	COG0552	protein localization to endoplasmic reticulum
W908_RS02405	COG1981	membrane
W908_RS02420	COG1126	abc transporter atp-binding protein
W908_RS02425	COG0765	amino acid transport
W908_RS02430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
W908_RS02440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
W908_RS02455	COG1177	transmembrane transport
W908_RS02460	COG1176	ABC-type spermidine putrescine transport system, permease component I
W908_RS02465	COG3842	ATPase activity
W908_RS02475	COG0174	glutamine synthetase
W908_RS02490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
W908_RS02495	COG0010	Belongs to the arginase family
W908_RS02505	COG0579	oxidoreductase
W908_RS02515	COG1802	Transcriptional regulator
W908_RS02520	COG0494	nUDIX hydrolase
W908_RS02535	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
W908_RS02540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
W908_RS02540	COG0543	2 iron, 2 sulfur cluster binding
W908_RS02545	COG0271	Belongs to the BolA IbaG family
W908_RS02550	COG1388	LysM domain
W908_RS02550	COG0741	lytic transglycosylase activity
W908_RS02560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
W908_RS02565	COG1181	Belongs to the D-alanine--D-alanine ligase family
W908_RS02570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
W908_RS02575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
W908_RS02580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
W908_RS02585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
W908_RS02600	COG1570	exodeoxyribonuclease VII activity
W908_RS02610	COG0268	Binds directly to 16S ribosomal RNA
W908_RS02615	COG2915	High frequency lysogenization protein hflD homolog
W908_RS02620	COG0482	sulfurtransferase activity
W908_RS02625	COG1702	phosphate starvation-inducible protein PhoH
W908_RS02635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
W908_RS02640	COG0668	transmembrane transport
W908_RS02645	COG0739	heme binding
W908_RS02650	COG1238	metal cluster binding
W908_RS02660	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
W908_RS02665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
W908_RS02675	COG4133	protoheme IX ABC transporter activity
W908_RS02680	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
W908_RS02685	COG0735	belongs to the Fur family
W908_RS02690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
W908_RS02695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
W908_RS02700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
W908_RS02705	COG2255	four-way junction helicase activity
W908_RS02710	COG0824	Thioesterase
W908_RS02715	COG0811	peptide transport
W908_RS02730	COG0751	glycine-tRNA ligase activity
W908_RS02735	COG1490	D-aminoacyl-tRNA deacylase activity
W908_RS02740	COG1393	Belongs to the ArsC family
W908_RS02745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
W908_RS02760	COG0450	alkyl hydroperoxide reductase
W908_RS02765	COG1199	ATP-dependent helicase activity
W908_RS02770	COG0142	geranyltranstransferase activity
W908_RS02775	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
W908_RS02780	COG1217	gtp-binding protein TYPA
W908_RS02785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
W908_RS02795	COG0066	3-isopropylmalate dehydratase activity
W908_RS02800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
W908_RS02805	COG0367	asparagine synthase
W908_RS02810	COG0328	RNA-DNA hybrid ribonuclease activity
W908_RS02815	COG2833	Protein of unknown function (DUF455)
W908_RS02820	COG1187	pseudouridine synthase activity
W908_RS02825	COG2867	negative regulation of translational initiation
W908_RS02830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
W908_RS02845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
W908_RS02850	COG0105	UTP biosynthetic process
W908_RS02855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
W908_RS02865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
W908_RS02875	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
W908_RS02880	COG1054	Belongs to the UPF0176 family
W908_RS02885	COG2813	Specifically methylates the guanine in position
W908_RS02890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
W908_RS02900	COG0047	phosphoribosylformylglycinamidine synthase activity
W908_RS02900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
W908_RS02905	COG0217	transcriptional regulatory protein
W908_RS02910	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
W908_RS02915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
W908_RS02930	COG0501	Belongs to the peptidase M48B family
W908_RS02960	COG0697	spore germination
W908_RS02985	COG1758	RNA polymerase activity
W908_RS02990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
W908_RS03015	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
W908_RS03020	COG1519	Transferase
W908_RS03025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
W908_RS03030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
W908_RS03035	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
W908_RS03040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
W908_RS03045	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
W908_RS03050	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
W908_RS03050	COG0316	Belongs to the HesB IscA family
W908_RS03055	COG0123	including yeast histone deacetylase and acetoin utilization protein
W908_RS03060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
W908_RS03070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
W908_RS03080	COG0456	acetyltransferase
W908_RS03085	COG0538	isocitrate dehydrogenase activity
W908_RS03105	COG0395	ABC-type sugar transport system, permease component
W908_RS03120	COG3842	ATPase activity
W908_RS03125	COG1349	DNA-binding transcription factor activity
W908_RS03140	COG1283	sodium-dependent phosphate transmembrane transporter activity
W908_RS03145	COG0183	Belongs to the thiolase family
W908_RS03155	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
W908_RS03160	COG3938	Belongs to the proline racemase family
W908_RS03275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
W908_RS03285	COG4968	Prepilin-type N-terminal cleavage methylation domain
W908_RS03300	COG1714	RDD family
W908_RS03350	COG0436	Aminotransferase
W908_RS03355	COG0556	nucleotide-excision repair
W908_RS03365	COG0659	secondary active sulfate transmembrane transporter activity
W908_RS03370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
W908_RS03385	COG0560	Phosphoserine phosphatase
W908_RS03390	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
W908_RS03395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
W908_RS03430	COG0582	viral genome integration into host DNA
W908_RS03455	COG0284	orotidine-5'-phosphate decarboxylase activity
W908_RS03470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
W908_RS03485	COG0259	pyridoxamine-phosphate oxidase activity
W908_RS03490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
W908_RS03495	COG1530	ribonuclease E activity
W908_RS03510	COG1968	undecaprenyl-diphosphatase activity
W908_RS03515	COG0308	aminopeptidase N
W908_RS03520	COG1546	Belongs to the CinA family
W908_RS03520	COG1058	Belongs to the CinA family
W908_RS03525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
W908_RS03535	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
W908_RS03540	COG0028	Belongs to the TPP enzyme family
W908_RS03545	COG0440	acetolactate synthase activity
W908_RS03550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
W908_RS03555	COG1183	phosphatidylcholine synthase activity
W908_RS03560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
W908_RS03570	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
W908_RS03575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
W908_RS03580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
W908_RS03590	COG2239	Acts as a magnesium transporter
W908_RS03600	COG1280	lysine exporter protein (LysE YggA)
W908_RS03610	COG1280	lysine exporter protein (LysE YggA)
W908_RS03620	COG0765	amino acid transport
W908_RS03625	COG0765	amino acid transport
W908_RS03635	COG1522	sequence-specific DNA binding
W908_RS03640	COG1126	abc transporter atp-binding protein
W908_RS03655	COG1177	transmembrane transport
W908_RS03660	COG1176	ABC-type spermidine putrescine transport system, permease component I
W908_RS03665	COG3842	ATPase activity
W908_RS03670	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
W908_RS03675	COG1733	regulation of RNA biosynthetic process
W908_RS03680	COG0604	alcohol dehydrogenase
W908_RS03685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
W908_RS03690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
W908_RS03715	COG1185	polyribonucleotide nucleotidyltransferase activity
W908_RS03720	COG2850	peptidyl-arginine hydroxylation
W908_RS03730	COG2264	protein methyltransferase activity
W908_RS03755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
W908_RS03760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
W908_RS03775	COG1126	abc transporter atp-binding protein
W908_RS03780	COG0765	amino acid transport
W908_RS03785	COG0765	amino acid transport
W908_RS03795	COG1686	Belongs to the peptidase S11 family
W908_RS03800	COG0772	Belongs to the SEDS family
W908_RS03810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
W908_RS03835	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
W908_RS03840	COG0617	tRNA 3'-terminal CCA addition
W908_RS03845	COG0300	oxidoreductase activity
W908_RS03850	COG1722	exodeoxyribonuclease VII activity
W908_RS03855	COG0142	geranyltranstransferase activity
W908_RS03860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
W908_RS03865	COG0416	fatty acid biosynthetic process
W908_RS03870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
W908_RS03880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
W908_RS03890	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
W908_RS03895	COG0330	HflC and HflK could
W908_RS03900	COG0330	HflC and HflK could
W908_RS03905	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
W908_RS03910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
W908_RS03915	COG0557	exoribonuclease II activity
W908_RS03920	COG0129	dihydroxy-acid dehydratase activity
W908_RS03930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
W908_RS03950	COG1028	Short-chain dehydrogenase reductase Sdr
W908_RS03965	COG0326	Molecular chaperone. Has ATPase activity
W908_RS03985	COG0174	glutamine synthetase
W908_RS03990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
W908_RS03995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
W908_RS04000	COG0772	Belongs to the SEDS family
W908_RS04005	COG0488	(ABC) transporter
W908_RS04020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
W908_RS04035	COG1116	anion transmembrane transporter activity
W908_RS04040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
W908_RS04055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
W908_RS04060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
W908_RS04065	COG0686	Belongs to the AlaDH PNT family
W908_RS04085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
W908_RS04090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
W908_RS04095	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
W908_RS04110	COG1012	belongs to the aldehyde dehydrogenase family
W908_RS04120	COG4948	Mandelate Racemase Muconate Lactonizing
W908_RS04125	COG2084	Dehydrogenase
W908_RS04130	COG0339	signal peptide processing
W908_RS04140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
W908_RS04145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
W908_RS04155	COG0459	protein refolding
W908_RS04160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
W908_RS04170	COG0194	GDP metabolic process
W908_RS04175	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
W908_RS04180	COG0728	peptidoglycan biosynthetic process
W908_RS04185	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
W908_RS04190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
W908_RS04195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
W908_RS04215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
W908_RS04220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
W908_RS04225	COG2967	ApaG domain
W908_RS04230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
W908_RS04235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
W908_RS04245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
W908_RS04250	COG0321	lipoyl(octanoyl) transferase activity
W908_RS04255	COG2921	Belongs to the UPF0250 family
W908_RS04275	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
W908_RS04280	COG0633	Ferredoxin
W908_RS04290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
W908_RS04310	COG1126	abc transporter atp-binding protein
W908_RS04315	COG0765	amino acid transport
W908_RS04320	COG4597	amino acid ABC transporter
W908_RS04325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
W908_RS04330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
W908_RS04330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
W908_RS04335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
W908_RS04345	COG2885	chlorophyll binding
W908_RS04350	COG0823	Involved in the tonB-independent uptake of proteins
W908_RS04360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
W908_RS04370	COG2814	Major facilitator Superfamily
W908_RS04375	COG0629	single-stranded DNA binding
W908_RS04380	COG0736	holo-[acyl-carrier-protein] synthase activity
W908_RS04385	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
W908_RS04390	COG1381	Involved in DNA repair and RecF pathway recombination
W908_RS04395	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
W908_RS04405	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
W908_RS04420	COG2515	1-aminocyclopropane-1-carboxylate deaminase
W908_RS04425	COG4176	ABC-type proline glycine betaine transport system permease component
W908_RS04430	COG4175	Glycine betaine
W908_RS04515	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
W908_RS04525	COG1401	restriction endodeoxyribonuclease activity
W908_RS04545	COG0582	viral genome integration into host DNA
W908_RS04580	COG0793	Belongs to the peptidase S41A family
W908_RS04585	COG0681	Belongs to the peptidase S26 family
W908_RS04590	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
W908_RS04605	COG0077	Prephenate dehydratase
W908_RS04605	COG1605	Chorismate mutase
W908_RS04610	COG4206	TonB-dependent receptor
W908_RS04625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
W908_RS04630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
W908_RS04635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
W908_RS04665	COG2827	Endonuclease containing a URI domain
W908_RS04670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
W908_RS04675	COG0745	RESPONSE REGULATOR receiver
W908_RS04680	COG2205	protein histidine kinase activity
W908_RS04700	COG0280	phosphate acetyltransferase
W908_RS04705	COG1012	belongs to the aldehyde dehydrogenase family
W908_RS04750	COG0583	DNA-binding transcription factor activity
W908_RS04770	COG2313	pseudouridylate synthase activity
W908_RS04775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
W908_RS04780	COG3046	protein related to deoxyribodipyrimidine photolyase
W908_RS04785	COG0737	Belongs to the 5'-nucleotidase family
W908_RS04800	COG0813	purine-nucleoside phosphorylase activity
W908_RS04840	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
W908_RS04855	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
W908_RS04885	COG0489	protein tyrosine kinase activity
W908_RS04895	COG0443	Heat shock 70 kDa protein
W908_RS04900	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
W908_RS04905	COG0316	Belongs to the HesB IscA family
W908_RS04910	COG0822	iron-sulfur transferase activity
W908_RS04915	COG1104	cysteine desulfurase activity
W908_RS04920	COG1959	2 iron, 2 sulfur cluster binding
W908_RS04940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
W908_RS04955	COG0501	Belongs to the peptidase M48B family
W908_RS04960	COG1162	GTPase activity
W908_RS04980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
W908_RS04990	COG0837	glucose binding
W908_RS05010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
W908_RS05015	COG0656	L-ascorbic acid biosynthetic process
W908_RS05020	COG3842	ATPase activity
W908_RS05025	COG0395	ABC-type sugar transport system, permease component
W908_RS05030	COG1175	transmembrane transport
W908_RS05035	COG1653	transport
W908_RS05055	COG5002	protein histidine kinase activity
W908_RS05055	COG3850	Histidine kinase
W908_RS05060	COG0745	RESPONSE REGULATOR receiver
W908_RS05075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
W908_RS05090	COG0395	ABC-type sugar transport system, permease component
W908_RS05095	COG1175	transmembrane transport
W908_RS05105	COG3684	Belongs to the aldolase LacD family
W908_RS05115	COG0673	inositol 2-dehydrogenase activity
W908_RS05120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
W908_RS05125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
W908_RS05130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
W908_RS05135	COG1414	Transcriptional regulator
W908_RS05150	COG3386	PFAM SMP-30 Gluconolaconase
W908_RS05155	COG0800	Aldolase
W908_RS05160	COG3734	2-keto-3-deoxy-galactonokinase
W908_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
W908_RS05170	COG0129	dihydroxy-acid dehydratase activity
W908_RS05180	COG0395	ABC-type sugar transport system, permease component
W908_RS05185	COG1175	transmembrane transport
W908_RS05195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
W908_RS05200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
W908_RS05210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
W908_RS05225	COG1079	Belongs to the binding-protein-dependent transport system permease family
W908_RS05230	COG4603	Belongs to the binding-protein-dependent transport system permease family
W908_RS05235	COG3845	ABC transporter
W908_RS05245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
W908_RS05250	COG2080	2 iron, 2 sulfur cluster binding
W908_RS05255	COG2351	hydroxyisourate hydrolase activity
W908_RS05260	COG0402	S-adenosylhomocysteine deaminase activity
W908_RS05275	COG4266	Belongs to the allantoicase family
W908_RS05280	COG3195	allantoin biosynthetic process
W908_RS05280	COG3648	Uricase
W908_RS05290	COG1744	ABC transporter substrate-binding protein PnrA-like
W908_RS05295	COG3845	ABC transporter
W908_RS05300	COG4603	Belongs to the binding-protein-dependent transport system permease family
W908_RS05305	COG1079	Belongs to the binding-protein-dependent transport system permease family
W908_RS05320	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
W908_RS05325	COG1012	belongs to the aldehyde dehydrogenase family
W908_RS05330	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
W908_RS05340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
W908_RS05345	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
W908_RS05350	COG4608	Belongs to the ABC transporter superfamily
W908_RS05355	COG0444	Belongs to the ABC transporter superfamily
W908_RS05360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
W908_RS05365	COG0601	transmembrane transport
W908_RS05370	COG4166	transmembrane transport
W908_RS05395	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
W908_RS05405	COG3088	subunit of a heme lyase
W908_RS05410	COG0488	(ABC) transporter
W908_RS05425	COG0322	excinuclease ABC activity
W908_RS05435	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
W908_RS05440	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
W908_RS05445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
W908_RS05450	COG1119	ATPase activity
W908_RS05485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
W908_RS05500	COG0481	GTPase activity
W908_RS05505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
W908_RS05510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
W908_RS05515	COG0318	PFAM AMP-dependent synthetase and ligase
W908_RS05520	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
W908_RS05555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
W908_RS05555	COG0446	pyridine nucleotide-disulphide oxidoreductase
W908_RS05560	COG4311	Sarcosine oxidase, delta subunit
W908_RS05565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
W908_RS05575	COG0583	DNA-binding transcription factor activity
W908_RS05585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
W908_RS05590	COG4176	ABC-type proline glycine betaine transport system permease component
W908_RS05595	COG4175	Glycine betaine
W908_RS05595	COG0517	IMP dehydrogenase activity
W908_RS05605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
W908_RS05615	COG0069	glutamate synthase activity
W908_RS05625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
W908_RS05640	COG1410	methionine synthase
W908_RS05640	COG0646	methionine synthase
W908_RS05645	COG0567	Dehydrogenase, E1 component
W908_RS05650	COG0508	dehydrogenase complex catalyzes the overall conversion of
W908_RS05655	COG0004	ammonium transporteR
W908_RS05685	COG0534	Mate efflux family protein
W908_RS05730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
W908_RS05735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
W908_RS05740	COG0628	permease
W908_RS05750	COG0776	regulation of translation
W908_RS05755	COG0072	phenylalanine-tRNA ligase activity
W908_RS05755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
W908_RS05760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
W908_RS05765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
W908_RS05770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
W908_RS05775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
W908_RS05800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
W908_RS05825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
W908_RS05835	COG3608	succinylglutamate desuccinylase aspartoacylase
W908_RS05860	COG0776	regulation of translation
W908_RS05865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
W908_RS05870	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
W908_RS05880	COG1214	PFAM Peptidase M22, glycoprotease
W908_RS05885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
W908_RS05890	COG3142	Participates in the control of copper homeostasis
W908_RS05895	COG0360	Binds together with S18 to 16S ribosomal RNA
W908_RS05900	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
W908_RS05905	COG0359	binds to the 23S rRNA
W908_RS05910	COG0305	Participates in initiation and elongation during chromosome replication
W908_RS05925	COG0124	histidyl-tRNA synthetase
W908_RS05935	COG1160	GTP binding
W908_RS05940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
W908_RS05945	COG0504	CTP synthase activity
W908_RS05950	COG1132	(ABC) transporter
W908_RS05960	COG1278	Cold shock
W908_RS05965	COG0500	methyltransferase
W908_RS05975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
W908_RS05990	COG2364	Membrane
W908_RS06000	COG0314	molybdopterin synthase activity
W908_RS06005	COG0746	molybdenum cofactor guanylyltransferase activity
W908_RS06010	COG0303	'Molybdopterin
W908_RS06015	COG0315	cyclic pyranopterin monophosphate synthase activity
W908_RS06020	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
W908_RS06025	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
W908_RS06030	COG0521	Mo-molybdopterin cofactor biosynthetic process
W908_RS06070	COG1850	ribulose-bisphosphate carboxylase activity
W908_RS06080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
W908_RS06100	COG0006	proline dipeptidase activity
W908_RS06105	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
W908_RS06125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
W908_RS06130	COG0569	domain protein
W908_RS06135	COG0745	RESPONSE REGULATOR receiver
W908_RS06140	COG5000	phosphorelay sensor kinase activity
W908_RS06150	COG0742	ribosomal rna small subunit methyltransferase
W908_RS06155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
W908_RS06160	COG0443	Heat shock 70 kDa protein
W908_RS06165	COG0484	heat shock protein binding
W908_RS06170	COG0148	phosphopyruvate hydratase activity
W908_RS06175	COG4536	flavin adenine dinucleotide binding
W908_RS06180	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
W908_RS06185	COG0688	phosphatidylethanolamine metabolic process
W908_RS06190	COG0442	prolyl-tRNA aminoacylation
W908_RS06195	COG1994	Peptidase M50
W908_RS06200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
W908_RS06205	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
W908_RS06210	COG0154	amidase activity
W908_RS06215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
W908_RS06220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
W908_RS06225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
W908_RS06230	COG1187	pseudouridine synthase activity
W908_RS06235	COG0180	Tryptophanyl-tRNA synthetase
W908_RS06250	COG0354	folic acid binding
W908_RS06275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
W908_RS06285	COG1496	oxidoreductase activity
W908_RS06290	COG0564	pseudouridine synthase activity
W908_RS06295	COG1091	dTDP-4-dehydrorhamnose reductase activity
W908_RS06310	COG1088	dTDP-glucose 4,6-dehydratase activity
W908_RS06330	COG0457	Tetratricopeptide repeat
W908_RS06335	COG0457	Tetratricopeptide repeat
W908_RS06345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
W908_RS06350	COG0045	succinate-CoA ligase (ADP-forming) activity
W908_RS06355	COG2301	Belongs to the HpcH HpaI aldolase family
W908_RS06380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
W908_RS06385	COG0799	negative regulation of ribosome biogenesis
W908_RS06390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
W908_RS06405	COG1509	lysine 2,3-aminomutase activity
W908_RS06410	COG0210	DNA helicase
W908_RS06420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
W908_RS06425	COG0247	lactate metabolic process
W908_RS06430	COG0277	FAD linked oxidase domain protein
W908_RS06435	COG0277	FAD linked oxidase domain protein
W908_RS06440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
W908_RS06445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
W908_RS06450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
W908_RS06455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
W908_RS06460	COG0717	Belongs to the dCTP deaminase family
W908_RS06470	COG4175	Glycine betaine
W908_RS06470	COG3448	diguanylate cyclase activity
W908_RS06475	COG4176	ABC-type proline glycine betaine transport system permease component
W908_RS06490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
W908_RS06495	COG1469	GTP cyclohydrolase I activity
W908_RS06500	COG0720	synthase
W908_RS06510	COG0537	adenosine 5'-monophosphoramidase activity
W908_RS06515	COG0778	Nitroreductase
W908_RS06530	COG2813	Specifically methylates the guanine in position
W908_RS06535	COG2962	Rard protein
W908_RS06560	COG0410	ABC transporter
W908_RS06570	COG2350	Protein conserved in bacteria
W908_RS06575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
W908_RS06580	COG2877	3-deoxy-8-phosphooctulonate synthase activity
W908_RS06585	COG0134	indole-3-glycerol-phosphate synthase activity
W908_RS06600	COG0415	Belongs to the DNA photolyase family
W908_RS06610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
W908_RS06620	COG2022	thiamine diphosphate biosynthetic process
W908_RS06625	COG0156	8-amino-7-oxononanoate synthase activity
W908_RS06630	COG2267	carboxylic ester hydrolase activity
W908_RS06635	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
W908_RS06655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
W908_RS06660	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
W908_RS06665	COG1663	tetraacyldisaccharide 4'-kinase activity
W908_RS06675	COG1136	(ABC) transporter
W908_RS06680	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
W908_RS06685	COG5016	pyruvate
W908_RS06685	COG0511	ligase activity, forming carbon-carbon bonds
W908_RS06700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
W908_RS06720	COG0802	atpase or kinase
W908_RS06725	COG0860	N-Acetylmuramoyl-L-alanine amidase
W908_RS06745	COG0493	'glutamate synthase
W908_RS06750	COG0335	large ribosomal subunit rRNA binding
W908_RS06755	COG4974	Belongs to the 'phage' integrase family
W908_RS06775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
W908_RS06780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
W908_RS06785	COG0505	Belongs to the CarA family
W908_RS06800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
W908_RS06815	COG0009	L-threonylcarbamoyladenylate synthase
W908_RS06820	COG0613	PHP domain protein
W908_RS06825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
W908_RS06875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
W908_RS06905	COG0110	maltose O-acetyltransferase activity
W908_RS06935	COG0546	phosphoglycolate phosphatase activity
W908_RS06970	COG2089	acid synthase
W908_RS06990	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
W908_RS06995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
W908_RS07000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
W908_RS07005	COG1028	Short-chain dehydrogenase reductase Sdr
W908_RS07005	COG3347	Dehydrogenase
W908_RS07010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
W908_RS07015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
W908_RS07015	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
W908_RS07020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
W908_RS07025	COG0859	PFAM glycosyl transferase family 9
W908_RS07035	COG1215	transferase activity, transferring glycosyl groups
W908_RS07040	COG0463	Glycosyl transferase, family 2
W908_RS07060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
W908_RS07075	COG0859	PFAM glycosyl transferase family 9
W908_RS07085	COG0859	PFAM glycosyl transferase family 9
W908_RS07090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
W908_RS07095	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
W908_RS07100	COG0542	response to heat
W908_RS07110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
W908_RS07120	COG0519	Catalyzes the synthesis of GMP from XMP
W908_RS07120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
W908_RS07150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
W908_RS07155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
W908_RS07160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
W908_RS07165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
W908_RS07170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
W908_RS07175	COG0557	exoribonuclease II activity
W908_RS07180	COG2917	probably involved in intracellular septation
W908_RS07200	COG2233	PERMEase
W908_RS07205	COG3842	ATPase activity
W908_RS07220	COG1175	transmembrane transport
W908_RS07235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
W908_RS07245	COG2226	methyltransferase
W908_RS07255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
W908_RS07260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
W908_RS07270	COG4193	domain, Protein
W908_RS07270	COG5263	repeat protein
W908_RS07275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
W908_RS07280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
W908_RS07290	COG0084	hydrolase, TatD family'
W908_RS07295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
W908_RS07305	COG0513	Belongs to the DEAD box helicase family
W908_RS07310	COG1278	Cold shock
W908_RS07315	COG2925	Exonuclease
W908_RS07320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
W908_RS07330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
W908_RS07335	COG0131	Imidazoleglycerol-phosphate dehydratase
W908_RS07340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
W908_RS07345	COG4989	oxidoreductase activity
W908_RS07350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
W908_RS07355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
W908_RS07375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
W908_RS07380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
W908_RS07390	COG5265	(ABC) transporter
W908_RS07400	COG0842	Transport permease protein
W908_RS07405	COG1131	(ABC) transporter
W908_RS07410	COG0508	dehydrogenase complex catalyzes the overall conversion of
W908_RS07415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
W908_RS07420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
W908_RS07435	COG0242	peptide deformylase activity
W908_RS07440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
W908_RS07450	COG0138	bifunctional purine biosynthesis protein purh
W908_RS07460	COG1473	amidohydrolase
W908_RS07475	COG0527	aspartate kinase activity
W908_RS07480	COG2095	MarC family integral membrane protein
W908_RS07485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
W908_RS07490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
W908_RS07495	COG0312	modulator of DNA gyrase
W908_RS07505	COG2914	Belongs to the UPF0125 (RnfH) family
W908_RS07510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
W908_RS07515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
W908_RS07520	COG1137	ATPase activity
W908_RS07525	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
W908_RS07525	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
W908_RS07530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
W908_RS07545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
W908_RS07550	COG0228	four-way junction DNA binding
W908_RS07555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
W908_RS07565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
W908_RS07570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
W908_RS07590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
W908_RS07605	COG2175	clavaminate synthase activity
W908_RS07620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
W908_RS07625	COG0708	Exodeoxyribonuclease III
W908_RS07630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
W908_RS07635	COG3030	protein affecting phage T7 exclusion by the F plasmid
W908_RS07640	COG0285	dihydrofolate synthase activity
W908_RS07660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
W908_RS07670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
W908_RS07675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
W908_RS07680	COG1862	Preprotein translocase
W908_RS07685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
W908_RS07705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
W908_RS07735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
W908_RS07740	COG2918	glutathione biosynthetic process
W908_RS07745	COG0494	nUDIX hydrolase
W908_RS07755	COG3022	response to hydroperoxide
W908_RS07760	COG0067	glutamate synthase
W908_RS07760	COG0070	glutamate synthase
W908_RS07760	COG0069	glutamate synthase activity
W908_RS07770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
W908_RS07775	COG0424	maF-like protein
W908_RS07780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
W908_RS07795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
W908_RS07800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
W908_RS07805	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
W908_RS07810	COG0159	tryptophan synthase activity
W908_RS07815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
W908_RS07820	COG0254	rRNA binding
W908_RS07830	COG0306	phosphate transporter
W908_RS07835	COG1392	Phosphate transport regulator
W908_RS07840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
W908_RS07845	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
W908_RS07850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
W908_RS07860	COG2175	clavaminate synthase activity
W908_RS07865	COG0626	cystathionine gamma-synthase activity
W908_RS07870	COG1074	ATP-dependent DNA helicase activity
W908_RS07875	COG0018	arginyl-trna synthetase
W908_RS07880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
W908_RS07880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
W908_RS07885	COG1121	(ABC) transporter
W908_RS07890	COG2171	N-acyltransferase activity
W908_RS07905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
W908_RS07910	COG0564	pseudouridine synthase activity
W908_RS07915	COG0084	hydrolase, TatD family'
W908_RS07920	COG0357	Ribosomal RNA small subunit methyltransferase G
W908_RS07925	COG0445	tRNA wobble uridine modification
W908_RS07930	COG3588	fructose-bisphosphate aldolase
W908_RS07935	COG0469	pyruvate kinase activity
W908_RS07940	COG0126	phosphoglycerate kinase activity
W908_RS07945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
W908_RS07950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
W908_RS07960	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
W908_RS07965	COG3383	formate dehydrogenase (NAD+) activity
W908_RS07975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
W908_RS07980	COG2759	Belongs to the formate--tetrahydrofolate ligase family
W908_RS07985	COG5598	trimethylamine methyltransferase
W908_RS08000	COG0646	methionine synthase
W908_RS08000	COG1410	methionine synthase
W908_RS08015	COG5012	cobalamin binding
W908_RS08030	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
W908_RS08060	COG0673	inositol 2-dehydrogenase activity
W908_RS08065	COG3842	ATPase activity
W908_RS08075	COG0395	ABC-type sugar transport system, permease component
W908_RS08090	COG2188	Transcriptional regulator
W908_RS08095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
W908_RS08100	COG0363	glucosamine-6-phosphate deaminase activity
W908_RS08110	COG1522	sequence-specific DNA binding
W908_RS08125	COG0010	Belongs to the arginase family
W908_RS08150	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
W908_RS08160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
W908_RS08205	COG1476	TRANSCRIPTIONal
W908_RS08255	COG1216	Glycosyl transferase, family 2
W908_RS08255	COG0438	transferase activity, transferring glycosyl groups
W908_RS08285	COG0237	dephospho-CoA kinase activity
W908_RS08290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
W908_RS08295	COG1136	(ABC) transporter
W908_RS08300	COG2755	lipolytic protein G-D-S-L family
W908_RS08305	COG3411	Ferredoxin
W908_RS08310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
W908_RS08320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
W908_RS08325	COG0151	Belongs to the GarS family
W908_RS08330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
W908_RS08335	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
W908_RS08340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
W908_RS08345	COG0195	Participates in both transcription termination and antitermination
W908_RS08345	COG2251	uridine kinase activity
W908_RS08350	COG0779	Required for maturation of 30S ribosomal subunits
W908_RS08360	COG0189	ligase activity
W908_RS08365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
W908_RS08370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
W908_RS08375	COG2951	lytic endotransglycosylase activity
W908_RS08380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
W908_RS08385	COG0540	Belongs to the ATCase OTCase family
W908_RS08390	COG3079	Belongs to the UPF0149 family
W908_RS08405	COG0492	ferredoxin-NADP+ reductase activity
W908_RS08410	COG1674	ftsk spoiiie
W908_RS08415	COG2181	nitrate reductase activity
W908_RS08420	COG0747	negative chemotaxis
W908_RS08425	COG0601	transmembrane transport
W908_RS08430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
W908_RS08435	COG0444	Belongs to the ABC transporter superfamily
W908_RS08440	COG4608	Belongs to the ABC transporter superfamily
W908_RS08450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
W908_RS08460	COG1024	Enoyl-CoA hydratase
W908_RS08465	COG0318	PFAM AMP-dependent synthetase and ligase
W908_RS08490	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
W908_RS08510	COG1999	signal sequence binding
W908_RS08520	COG0109	protoheme IX farnesyltransferase activity
W908_RS08530	COG0107	imidazoleglycerol-phosphate synthase activity
W908_RS08535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
W908_RS08540	COG0575	Belongs to the CDS family
W908_RS08545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
W908_RS08550	COG0739	heme binding
W908_RS08555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
W908_RS08570	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
W908_RS08575	COG1194	a g-specific adenine glycosylase
W908_RS08580	COG0196	riboflavin kinase activity
W908_RS08585	COG0418	dihydroorotase activity
W908_RS08590	COG0653	protein targeting
W908_RS08600	COG0723	plastoquinol--plastocyanin reductase activity
W908_RS08605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
W908_RS08610	COG2857	Cytochrome c1
W908_RS08615	COG0625	glutathione transferase activity
W908_RS08620	COG2969	positive regulation of protein catabolic process
W908_RS08625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
W908_RS08630	COG0167	dihydroorotate dehydrogenase activity
W908_RS08635	COG0495	leucyl-tRNA aminoacylation
W908_RS08640	COG3954	Phosphoribulokinase
W908_RS08650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
W908_RS08655	COG0592	DNA-directed DNA polymerase activity