locus-tag	class	description
COSY_RS00010	COG0592	DNA-directed DNA polymerase activity
COSY_RS00015	COG0187	DNA topoisomerase II activity
COSY_RS00025	COG0495	leucyl-tRNA aminoacylation
COSY_RS00035	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
COSY_RS00045	COG0625	glutathione transferase activity
COSY_RS00050	COG2857	Cytochrome c1
COSY_RS00055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
COSY_RS00060	COG0723	plastoquinol--plastocyanin reductase activity
COSY_RS00070	COG0653	protein targeting
COSY_RS00075	COG0418	dihydroorotase activity
COSY_RS00080	COG0196	riboflavin kinase activity
COSY_RS00085	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
COSY_RS00095	COG0436	Aminotransferase
COSY_RS00110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
COSY_RS00120	COG0739	heme binding
COSY_RS00125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
COSY_RS00130	COG0575	Belongs to the CDS family
COSY_RS00135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
COSY_RS00140	COG0107	imidazoleglycerol-phosphate synthase activity
COSY_RS00150	COG0109	protoheme IX farnesyltransferase activity
COSY_RS00180	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
COSY_RS00200	COG3278	Belongs to the heme-copper respiratory oxidase family
COSY_RS00210	COG2010	Cytochrome c
COSY_RS00230	COG1674	ftsk spoiiie
COSY_RS00235	COG0492	ferredoxin-NADP+ reductase activity
COSY_RS00245	COG0540	Belongs to the ATCase OTCase family
COSY_RS00250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
COSY_RS00260	COG1477	protein flavinylation
COSY_RS00265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
COSY_RS00270	COG0189	ligase activity
COSY_RS00280	COG0779	Required for maturation of 30S ribosomal subunits
COSY_RS00285	COG0195	Participates in both transcription termination and antitermination
COSY_RS00290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
COSY_RS00295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
COSY_RS00305	COG0151	Belongs to the GarS family
COSY_RS00315	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
COSY_RS00320	COG0237	dephospho-CoA kinase activity
COSY_RS00330	COG1525	nuclease
COSY_RS00345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
COSY_RS00350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
COSY_RS00355	COG0126	phosphoglycerate kinase activity
COSY_RS00360	COG0469	pyruvate kinase activity
COSY_RS00370	COG0445	tRNA wobble uridine modification
COSY_RS00380	COG0084	hydrolase, TatD family'
COSY_RS00385	COG0564	pseudouridine synthase activity
COSY_RS00390	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
COSY_RS00395	COG2171	N-acyltransferase activity
COSY_RS00410	COG1121	(ABC) transporter
COSY_RS00420	COG0018	arginyl-trna synthetase
COSY_RS00425	COG1074	ATP-dependent DNA helicase activity
COSY_RS00430	COG0352	thiamine-phosphate diphosphorylase activity
COSY_RS00440	COG2046	Belongs to the sulfate adenylyltransferase family
COSY_RS00475	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
COSY_RS00480	COG0563	adenylate kinase activity
COSY_RS00485	COG0205	6-phosphofructokinase activity
COSY_RS00495	COG0215	cysteine-tRNA ligase activity
COSY_RS00500	COG0450	alkyl hydroperoxide reductase
COSY_RS00505	COG1773	rubredoxin
COSY_RS00510	COG0473	3-isopropylmalate dehydrogenase activity
COSY_RS00515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
COSY_RS00520	COG0494	nUDIX hydrolase
COSY_RS00525	COG0019	diaminopimelate decarboxylase activity
COSY_RS00540	COG0157	Belongs to the NadC ModD family
COSY_RS00545	COG1218	3'(2'),5'-bisphosphate nucleotidase
COSY_RS00555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
COSY_RS00560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
COSY_RS00570	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
COSY_RS00575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
COSY_RS00580	COG0006	proline dipeptidase activity
COSY_RS00585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
COSY_RS00600	COG0546	phosphoglycolate phosphatase activity
COSY_RS00605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
COSY_RS00610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
COSY_RS00615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
COSY_RS00625	COG0825	malonyl-CoA metabolic process
COSY_RS00635	COG1392	Phosphate transport regulator
COSY_RS00640	COG0306	phosphate transporter
COSY_RS00650	COG0513	Belongs to the DEAD box helicase family
COSY_RS00660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
COSY_RS00665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
COSY_RS00670	COG1466	dna polymerase III delta subunit
COSY_RS00680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
COSY_RS00685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
COSY_RS00690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
COSY_RS00700	COG4657	Part of a membrane complex involved in electron transport
COSY_RS00705	COG2878	Part of a membrane complex involved in electron transport
COSY_RS00710	COG4656	Part of a membrane complex involved in electron transport
COSY_RS00725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
COSY_RS00735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
COSY_RS00740	COG0045	succinate-CoA ligase (ADP-forming) activity
COSY_RS00745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
COSY_RS00750	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
COSY_RS00760	COG0137	argininosuccinate synthase activity
COSY_RS00775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
COSY_RS00785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
COSY_RS00790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
COSY_RS00800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
COSY_RS00800	COG0517	IMP dehydrogenase activity
COSY_RS00805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
COSY_RS00810	COG0049	tRNA binding
COSY_RS00815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
COSY_RS00820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
COSY_RS00825	COG0051	transcription antitermination factor activity, RNA binding
COSY_RS00830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
COSY_RS00835	COG0088	Forms part of the polypeptide exit tunnel
COSY_RS00840	COG0089	rRNA binding
COSY_RS00845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
COSY_RS00850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
COSY_RS00855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
COSY_RS00860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
COSY_RS00865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
COSY_RS00870	COG0255	Belongs to the universal ribosomal protein uL29 family
COSY_RS00875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
COSY_RS00880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
COSY_RS00885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
COSY_RS00890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
COSY_RS00895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
COSY_RS00900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
COSY_RS00905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
COSY_RS00910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
COSY_RS00915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
COSY_RS00920	COG1841	ribosomal large subunit assembly
COSY_RS00925	COG0200	Binds to the 23S rRNA
COSY_RS00930	COG0201	protein transport
COSY_RS00935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
COSY_RS00940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
COSY_RS00945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
COSY_RS00950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
COSY_RS00955	COG0202	RNA polymerase activity
COSY_RS00960	COG0203	ribosomal protein L17
COSY_RS00965	COG0828	Belongs to the bacterial ribosomal protein bS21 family
COSY_RS00970	COG0617	tRNA 3'-terminal CCA addition
COSY_RS00980	COG0218	Necessary for normal cell division and for the maintenance of normal septation
COSY_RS00995	COG0544	peptidyl-prolyl cis-trans isomerase activity
COSY_RS01000	COG0740	serine-type endopeptidase activity
COSY_RS01005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
COSY_RS01010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
COSY_RS01020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
COSY_RS01050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
COSY_RS01055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
COSY_RS01065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
COSY_RS01075	COG2210	Belongs to the sulfur carrier protein TusA family
COSY_RS01080	COG0425	Belongs to the sulfur carrier protein TusA family
COSY_RS01085	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
COSY_RS01090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
COSY_RS01095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
COSY_RS01100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
COSY_RS01105	COG0543	2 iron, 2 sulfur cluster binding
COSY_RS01110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
COSY_RS01125	COG0312	modulator of DNA gyrase
COSY_RS01130	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
COSY_RS01135	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
COSY_RS01140	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
COSY_RS01145	COG0649	NAD binding
COSY_RS01155	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
COSY_RS01160	COG1034	ATP synthesis coupled electron transport
COSY_RS01165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
COSY_RS01170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
COSY_RS01180	COG0713	ATP synthesis coupled electron transport
COSY_RS01195	COG1007	ATP synthesis coupled electron transport
COSY_RS01200	COG2226	methyltransferase
COSY_RS01215	COG0233	cytoplasmic translational termination
COSY_RS01220	COG0528	UMP kinase activity
COSY_RS01225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
COSY_RS01230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
COSY_RS01235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
COSY_RS01240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
COSY_RS01245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
COSY_RS01255	COG1648	precorrin-2 dehydrogenase activity
COSY_RS01255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
COSY_RS01270	COG0560	Phosphoserine phosphatase
COSY_RS01275	COG1138	Cytochrome C-type biogenesis protein
COSY_RS01285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
COSY_RS01290	COG0336	Belongs to the RNA methyltransferase TrmD family
COSY_RS01295	COG0347	Belongs to the P(II) protein family
COSY_RS01300	COG0004	ammonium transporteR
COSY_RS01305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
COSY_RS01315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
COSY_RS01320	COG0347	Belongs to the P(II) protein family
COSY_RS01330	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
COSY_RS01335	COG3707	response regulator
COSY_RS01345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
COSY_RS01350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
COSY_RS01355	COG0140	phosphoribosyl-ATP diphosphatase activity
COSY_RS01360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
COSY_RS01365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
COSY_RS01380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
COSY_RS01385	COG1560	Kdo2-lipid A biosynthetic process
COSY_RS01390	COG0358	DNA primase activity
COSY_RS01395	COG0275	rRNA processing
COSY_RS01400	COG2001	Belongs to the MraZ family
COSY_RS01405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
COSY_RS01415	COG1469	GTP cyclohydrolase I activity
COSY_RS01420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
COSY_RS01430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
COSY_RS01440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
COSY_RS01445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
COSY_RS01450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
COSY_RS01455	COG0277	FAD linked oxidase domain protein
COSY_RS01460	COG0277	FAD linked oxidase domain protein
COSY_RS01465	COG0247	lactate metabolic process
COSY_RS01470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
COSY_RS01480	COG0210	DNA helicase
COSY_RS01510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
COSY_RS01535	COG0564	pseudouridine synthase activity
COSY_RS01545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
COSY_RS01560	COG0354	folic acid binding
COSY_RS01565	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
COSY_RS01570	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
COSY_RS01575	COG0180	Tryptophanyl-tRNA synthetase
COSY_RS01585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
COSY_RS01590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
COSY_RS01600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COSY_RS01605	COG0154	amidase activity
COSY_RS01610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
COSY_RS01615	COG1994	Peptidase M50
COSY_RS01620	COG0442	prolyl-tRNA aminoacylation
COSY_RS01625	COG0688	phosphatidylethanolamine metabolic process
COSY_RS01630	COG4536	flavin adenine dinucleotide binding
COSY_RS01635	COG0148	phosphopyruvate hydratase activity
COSY_RS01655	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
COSY_RS01660	COG0142	geranyltranstransferase activity
COSY_RS01665	COG1199	ATP-dependent helicase activity
COSY_RS01670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
COSY_RS01675	COG0569	domain protein
COSY_RS01685	COG5000	phosphorelay sensor kinase activity
COSY_RS01690	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
COSY_RS01695	COG0742	ribosomal rna small subunit methyltransferase
COSY_RS01700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
COSY_RS01705	COG0443	Heat shock 70 kDa protein
COSY_RS01710	COG0484	heat shock protein binding
COSY_RS01715	COG0632	four-way junction helicase activity
COSY_RS01720	COG0066	3-isopropylmalate dehydratase activity
COSY_RS01725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
COSY_RS01730	COG0367	asparagine synthase
COSY_RS01735	COG0328	RNA-DNA hybrid ribonuclease activity
COSY_RS01745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
COSY_RS01750	COG0105	UTP biosynthetic process
COSY_RS01755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
COSY_RS01765	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
COSY_RS01775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
COSY_RS01780	COG0826	peptidase U32
COSY_RS01785	COG2813	Specifically methylates the guanine in position
COSY_RS01790	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
COSY_RS01795	COG0047	phosphoribosylformylglycinamidine synthase activity
COSY_RS01795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
COSY_RS01800	COG0217	transcriptional regulatory protein
COSY_RS01805	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
COSY_RS01810	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
COSY_RS01820	COG0024	Methionine aminopeptidase
COSY_RS01825	COG0501	Belongs to the peptidase M48B family
COSY_RS01830	COG1704	LemA family
COSY_RS01850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
COSY_RS01855	COG1758	RNA polymerase activity
COSY_RS01870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
COSY_RS01875	COG1519	Transferase
COSY_RS01880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
COSY_RS01885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
COSY_RS01890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
COSY_RS01895	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
COSY_RS01900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
COSY_RS01905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
COSY_RS01905	COG0316	Belongs to the HesB IscA family
COSY_RS01915	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
COSY_RS01925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
COSY_RS01965	COG0436	Aminotransferase
COSY_RS01970	COG0602	queuosine metabolic process
COSY_RS01980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
COSY_RS01990	COG0284	orotidine-5'-phosphate decarboxylase activity
COSY_RS02005	COG0259	pyridoxamine-phosphate oxidase activity
COSY_RS02010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
COSY_RS02015	COG1530	ribonuclease E activity
COSY_RS02020	COG0300	oxidoreductase activity
COSY_RS02030	COG1968	undecaprenyl-diphosphatase activity
COSY_RS02035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
COSY_RS02040	COG0028	Belongs to the TPP enzyme family
COSY_RS02050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
COSY_RS02055	COG1183	phosphatidylcholine synthase activity
COSY_RS02060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
COSY_RS02070	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
COSY_RS02075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
COSY_RS02080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
COSY_RS02095	COG2239	Acts as a magnesium transporter
COSY_RS02100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
COSY_RS02115	COG1185	polyribonucleotide nucleotidyltransferase activity
COSY_RS02120	COG0516	GMP reductase activity
COSY_RS02120	COG0517	IMP dehydrogenase activity
COSY_RS02130	COG0525	valine-tRNA ligase activity
COSY_RS02135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
COSY_RS02140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
COSY_RS02150	COG1686	Belongs to the peptidase S11 family
COSY_RS02155	COG0772	Belongs to the SEDS family
COSY_RS02170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COSY_RS02190	COG0795	lipopolysaccharide-transporting ATPase activity
COSY_RS02195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
COSY_RS02205	COG1722	exodeoxyribonuclease VII activity
COSY_RS02210	COG0142	geranyltranstransferase activity
COSY_RS02215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
COSY_RS02220	COG0416	fatty acid biosynthetic process
COSY_RS02225	COG0333	Belongs to the bacterial ribosomal protein bL32 family
COSY_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
COSY_RS02245	COG0483	inositol monophosphate 1-phosphatase activity
COSY_RS02250	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
COSY_RS02255	COG0326	Molecular chaperone. Has ATPase activity
COSY_RS02270	COG0408	coproporphyrinogen oxidase activity
COSY_RS02280	COG0174	glutamine synthetase
COSY_RS02285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
COSY_RS02290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
COSY_RS02295	COG0488	(ABC) transporter
COSY_RS02310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
COSY_RS02315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
COSY_RS02320	COG0646	methionine synthase
COSY_RS02320	COG1410	methionine synthase
COSY_RS02330	COG0629	single-stranded DNA binding
COSY_RS02335	COG2814	Major facilitator Superfamily
COSY_RS02345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
COSY_RS02355	COG0823	Involved in the tonB-independent uptake of proteins
COSY_RS02360	COG2885	chlorophyll binding
COSY_RS02370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
COSY_RS02375	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
COSY_RS02375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
COSY_RS02380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
COSY_RS02385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COSY_RS02390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
COSY_RS02415	COG0129	dihydroxy-acid dehydratase activity
COSY_RS02420	COG0557	exoribonuclease II activity
COSY_RS02425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
COSY_RS02430	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
COSY_RS02435	COG0330	HflC and HflK could
COSY_RS02440	COG0330	HflC and HflK could
COSY_RS02445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
COSY_RS02450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
COSY_RS02455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
COSY_RS02460	COG3864	Putative metallopeptidase domain
COSY_RS02470	COG2921	Belongs to the UPF0250 family
COSY_RS02475	COG0321	lipoyl(octanoyl) transferase activity
COSY_RS02480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
COSY_RS02495	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
COSY_RS02500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
COSY_RS02505	COG2967	ApaG domain
COSY_RS02510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
COSY_RS02515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
COSY_RS02525	COG0750	zinc metalloprotease
COSY_RS02535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
COSY_RS02540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
COSY_RS02545	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
COSY_RS02550	COG0728	peptidoglycan biosynthetic process
COSY_RS02555	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
COSY_RS02570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
COSY_RS02575	COG0459	protein refolding
COSY_RS02585	COG0187	DNA topoisomerase II activity
COSY_RS02590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
COSY_RS02595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
COSY_RS02610	COG0339	signal peptide processing
COSY_RS02620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COSY_RS02625	COG0489	protein tyrosine kinase activity
COSY_RS02635	COG0443	Heat shock 70 kDa protein
COSY_RS02650	COG0822	iron-sulfur transferase activity
COSY_RS02655	COG1104	cysteine desulfurase activity
COSY_RS02675	COG0037	tRNA processing
COSY_RS02685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
COSY_RS02695	COG0527	aspartate kinase activity
COSY_RS02700	COG0501	Belongs to the peptidase M48B family
COSY_RS02710	COG1162	GTPase activity
COSY_RS02715	COG2363	Small membrane protein
COSY_RS02725	COG0776	regulation of translation
COSY_RS02735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
COSY_RS02740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
COSY_RS02745	COG3088	subunit of a heme lyase
COSY_RS02750	COG0488	(ABC) transporter
COSY_RS02775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
COSY_RS02780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
COSY_RS02785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
COSY_RS02790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
COSY_RS02795	COG4137	Cytochrome C assembly protein
COSY_RS02800	COG0481	GTPase activity
COSY_RS02805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
COSY_RS02810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
COSY_RS02820	COG0736	holo-[acyl-carrier-protein] synthase activity
COSY_RS02825	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
COSY_RS02835	COG0571	ribonuclease III activity
COSY_RS02845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
COSY_RS02870	COG0793	Belongs to the peptidase S41A family
COSY_RS02875	COG0681	Belongs to the peptidase S26 family
COSY_RS02880	COG2920	part of a sulfur-relay system
COSY_RS02885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
COSY_RS02890	COG0287	Prephenate dehydrogenase
COSY_RS02900	COG1605	Chorismate mutase
COSY_RS02900	COG0077	Prephenate dehydratase
COSY_RS02905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
COSY_RS02910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
COSY_RS02925	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
COSY_RS02930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
COSY_RS02945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
COSY_RS02955	COG0776	regulation of translation
COSY_RS02960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
COSY_RS02960	COG0072	phenylalanine-tRNA ligase activity
COSY_RS02965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
COSY_RS02970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
COSY_RS02975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
COSY_RS02985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
COSY_RS03030	COG0776	regulation of translation
COSY_RS03035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COSY_RS03040	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
COSY_RS03050	COG1214	PFAM Peptidase M22, glycoprotease
COSY_RS03055	COG0360	Binds together with S18 to 16S ribosomal RNA
COSY_RS03060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
COSY_RS03065	COG0359	binds to the 23S rRNA
COSY_RS03075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
COSY_RS03080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
COSY_RS03100	COG0124	histidyl-tRNA synthetase
COSY_RS03110	COG1160	GTP binding
COSY_RS03115	COG0504	CTP synthase activity
COSY_RS03120	COG1132	(ABC) transporter
COSY_RS03145	COG0076	glutamate decarboxylase activity
COSY_RS03155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
COSY_RS03185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
COSY_RS03190	COG2815	serine threonine protein kinase
COSY_RS03190	COG0515	serine threonine protein kinase
COSY_RS03195	COG2223	nitrite transmembrane transporter activity
COSY_RS03200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
COSY_RS03205	COG0314	molybdopterin synthase activity
COSY_RS03210	COG0746	molybdenum cofactor guanylyltransferase activity
COSY_RS03215	COG0303	'Molybdopterin
COSY_RS03220	COG0315	cyclic pyranopterin monophosphate synthase activity
COSY_RS03225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
COSY_RS03230	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
COSY_RS03240	COG2181	nitrate reductase activity
COSY_RS03245	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
COSY_RS03250	COG1140	nitrate reductase beta subunit
COSY_RS03255	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
COSY_RS03260	COG0521	Mo-molybdopterin cofactor biosynthetic process
COSY_RS03280	COG1850	ribulose-bisphosphate carboxylase activity
COSY_RS03290	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
COSY_RS03305	COG3842	ATPase activity
COSY_RS03310	COG2132	Multicopper oxidase
COSY_RS03340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
COSY_RS03345	COG1393	Belongs to the ArsC family
COSY_RS03360	COG0751	glycine-tRNA ligase activity
COSY_RS03380	COG0811	peptide transport
COSY_RS03385	COG2255	four-way junction helicase activity
COSY_RS03390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
COSY_RS03395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
COSY_RS03400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
COSY_RS03405	COG0735	belongs to the Fur family
COSY_RS03410	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
COSY_RS03415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
COSY_RS03415	COG0616	signal peptide processing
COSY_RS03420	COG4133	protoheme IX ABC transporter activity
COSY_RS03430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
COSY_RS03435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
COSY_RS03445	COG1238	metal cluster binding
COSY_RS03455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
COSY_RS03470	COG0482	sulfurtransferase activity
COSY_RS03475	COG2915	High frequency lysogenization protein hflD homolog
COSY_RS03480	COG0268	Binds directly to 16S ribosomal RNA
COSY_RS03490	COG1570	exodeoxyribonuclease VII activity
COSY_RS03500	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
COSY_RS03505	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
COSY_RS03510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
COSY_RS03515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
COSY_RS03520	COG1181	Belongs to the D-alanine--D-alanine ligase family
COSY_RS03525	COG0271	Belongs to the BolA IbaG family
COSY_RS03530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
COSY_RS03535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
COSY_RS03550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
COSY_RS03565	COG1981	membrane
COSY_RS03570	COG0552	protein localization to endoplasmic reticulum
COSY_RS03575	COG0181	hydroxymethylbilane synthase activity
COSY_RS03585	COG0165	Argininosuccinate lyase
COSY_RS03590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
COSY_RS03595	COG0542	response to heat
COSY_RS03600	COG4660	Part of a membrane complex involved in electron transport
COSY_RS03605	COG2890	protein-(glutamine-N5) methyltransferase activity
COSY_RS03615	COG1077	Cell shape determining protein MreB Mrl
COSY_RS03620	COG1792	Involved in formation and maintenance of cell shape
COSY_RS03630	COG0768	penicillin binding
COSY_RS03635	COG0343	queuine tRNA-ribosyltransferase activity
COSY_RS03640	COG5265	(ABC) transporter
COSY_RS03645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
COSY_RS03645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
COSY_RS03650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
COSY_RS03655	COG0587	DNA-directed DNA polymerase activity
COSY_RS03665	COG3258	Cytochrome c
COSY_RS03690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
COSY_RS03695	COG0085	RNA polymerase activity
COSY_RS03700	COG0222	ribosome binding
COSY_RS03705	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
COSY_RS03710	COG0081	regulation of translation
COSY_RS03715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
COSY_RS03735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
COSY_RS03755	COG0281	malic enzyme
COSY_RS03760	COG0537	adenosine 5'-monophosphoramidase activity
COSY_RS03775	COG0778	Nitroreductase
COSY_RS03790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
COSY_RS03795	COG2877	3-deoxy-8-phosphooctulonate synthase activity
COSY_RS03800	COG0134	indole-3-glycerol-phosphate synthase activity
COSY_RS03805	COG1765	OsmC-like protein
COSY_RS03815	COG2022	thiamine diphosphate biosynthetic process
COSY_RS03820	COG0156	8-amino-7-oxononanoate synthase activity
COSY_RS03825	COG2267	carboxylic ester hydrolase activity
COSY_RS03845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
COSY_RS03850	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
COSY_RS03855	COG2835	tetraacyldisaccharide 4'-kinase activity
COSY_RS03860	COG1663	tetraacyldisaccharide 4'-kinase activity
COSY_RS03870	COG1136	(ABC) transporter
COSY_RS03875	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
COSY_RS03880	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
COSY_RS03900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
COSY_RS03905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
COSY_RS03930	COG0802	atpase or kinase
COSY_RS03940	COG1797	cobyrinic acid a,c-diamide synthase activity
COSY_RS03975	COG2920	part of a sulfur-relay system
COSY_RS03985	COG2923	Belongs to the DsrF TusC family
COSY_RS03990	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
COSY_RS03995	COG2221	Nitrite and sulphite reductase 4Fe-4S
COSY_RS04000	COG2221	Nitrite and sulphite reductase 4Fe-4S
COSY_RS04005	COG0493	'glutamate synthase
COSY_RS04010	COG0335	large ribosomal subunit rRNA binding
COSY_RS04015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
COSY_RS04025	COG2853	Lipoprotein
COSY_RS04030	COG0505	Belongs to the CarA family
COSY_RS04045	COG0482	sulfurtransferase activity
COSY_RS04055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
COSY_RS04060	COG0009	L-threonylcarbamoyladenylate synthase
COSY_RS04065	COG0613	PHP domain protein
COSY_RS04070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
COSY_RS04075	COG0166	Belongs to the GPI family
COSY_RS04110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
COSY_RS04115	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
COSY_RS04120	COG0542	response to heat
COSY_RS04125	COG0795	lipopolysaccharide-transporting ATPase activity
COSY_RS04130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
COSY_RS04130	COG0519	Catalyzes the synthesis of GMP from XMP
COSY_RS04145	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
COSY_RS04150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
COSY_RS04155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
COSY_RS04160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
COSY_RS04165	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
COSY_RS04170	COG0557	exoribonuclease II activity
COSY_RS04175	COG0509	glycine decarboxylation via glycine cleavage system
COSY_RS04180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
COSY_RS04185	COG2917	probably involved in intracellular septation
COSY_RS04205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
COSY_RS04210	COG3161	chorismate lyase activity
COSY_RS04215	COG0512	Glutamine amidotransferase of anthranilate synthase
COSY_RS04220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
COSY_RS04230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
COSY_RS04245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
COSY_RS04250	COG0513	Belongs to the DEAD box helicase family
COSY_RS04255	COG1278	Cold shock
COSY_RS04260	COG2925	Exonuclease
COSY_RS04265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
COSY_RS04270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
COSY_RS04275	COG0131	Imidazoleglycerol-phosphate dehydratase
COSY_RS04280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
COSY_RS04285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
COSY_RS04290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
COSY_RS04305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
COSY_RS04310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
COSY_RS04315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
COSY_RS04330	COG0842	Transport permease protein
COSY_RS04335	COG1131	(ABC) transporter
COSY_RS04340	COG0508	dehydrogenase complex catalyzes the overall conversion of
COSY_RS04345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
COSY_RS04350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
COSY_RS04360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
COSY_RS04375	COG0138	bifunctional purine biosynthesis protein purh
COSY_RS04380	COG0513	Belongs to the DEAD box helicase family
COSY_RS04385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
COSY_RS04390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
COSY_RS04395	COG0312	modulator of DNA gyrase
COSY_RS04410	COG2914	Belongs to the UPF0125 (RnfH) family
COSY_RS04415	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
COSY_RS04425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
COSY_RS04430	COG1137	ATPase activity
COSY_RS04440	COG0101	tRNA pseudouridine synthase activity
COSY_RS04445	COG3273	potassium ion transport
COSY_RS04445	COG0471	metal ion transport
COSY_RS04455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
COSY_RS04460	COG0228	four-way junction DNA binding
COSY_RS04475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
COSY_RS04480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
COSY_RS04495	COG0708	Exodeoxyribonuclease III
COSY_RS04500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
COSY_RS04505	COG3030	protein affecting phage T7 exclusion by the F plasmid
COSY_RS04510	COG0285	dihydrofolate synthase activity
COSY_RS04530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
COSY_RS04540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
COSY_RS04545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
COSY_RS04550	COG1862	Preprotein translocase
COSY_RS04555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
COSY_RS04570	COG3118	belongs to the thioredoxin family
COSY_RS04605	COG2197	response regulator
COSY_RS04610	COG3850	Histidine kinase
COSY_RS04615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
COSY_RS04620	COG2918	glutathione biosynthetic process
COSY_RS04630	COG0069	glutamate synthase activity
COSY_RS04630	COG0070	glutamate synthase
COSY_RS04630	COG0067	glutamate synthase
COSY_RS04640	COG0424	maF-like protein
COSY_RS04645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
COSY_RS04650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
COSY_RS04655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
COSY_RS04660	COG1047	Peptidyl-prolyl cis-trans
COSY_RS04665	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
COSY_RS04670	COG0159	tryptophan synthase activity
COSY_RS04675	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
COSY_RS04680	COG0254	rRNA binding
COSY_RS04685	COG2217	Heavy metal translocating P-type atpase
COSY_RS04695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
COSY_RS04700	COG0133	tryptophan synthase activity
COSY_RS04730	COG0230	Belongs to the bacterial ribosomal protein bL34 family
COSY_RS04735	COG0594	ribonuclease P activity
COSY_RS04740	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
COSY_RS04745	COG0706	membrane insertase activity
COSY_RS04750	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
COSY_RS04755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
COSY_RS04760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
COSY_RS04765	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
COSY_RS04770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
COSY_RS04775	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
COSY_RS04780	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
COSY_RS04785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
COSY_RS04795	COG0356	it plays a direct role in the translocation of protons across the membrane
COSY_RS04805	COG0446	pyridine nucleotide-disulphide oxidoreductase
COSY_RS04810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
COSY_RS04815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
COSY_RS04820	COG4232	protein-disulfide reductase activity
COSY_RS04825	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
COSY_RS04830	COG0511	ligase activity, forming carbon-carbon bonds
COSY_RS04835	COG0439	Biotin carboxylase
COSY_RS04840	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
COSY_RS04845	COG0316	Belongs to the HesB IscA family
COSY_RS04870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
COSY_RS04875	COG0193	aminoacyl-tRNA hydrolase activity
COSY_RS04880	COG0012	GTP binding
COSY_RS04885	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
COSY_RS04890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
COSY_RS04895	COG0052	Belongs to the universal ribosomal protein uS2 family
COSY_RS04900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
COSY_RS04925	COG0149	triose-phosphate isomerase activity
COSY_RS04945	COG2951	lytic endotransglycosylase activity
COSY_RS04965	COG0352	thiamine-phosphate diphosphorylase activity