locus_tag old_locus_tag gene Name start end strand product note type ID NCBI COSY_RS00005 COSY_0001 COSY_RS00005 1 1293 + chromosomal replication initiator protein DnaA gene gene0 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00005 COSY_RS00010 COSY_0002 COSY_RS00010 1507 2610 + DNA polymerase III subunit beta gene gene1 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00010 COSY_RS00015 COSY_0003 gyrB gyrB 2711 5128 + DNA gyrase subunit B negatively supercoils closed circular double-stranded DNA gene gene2 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00015 COSY_RS00020 COSY_0004 COSY_RS00020 5149 6027 + phosphoribulokinase gene gene3 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00020 COSY_RS00025 COSY_0005 leuS leuS 6084 8531 - leucine--tRNA ligase leucine--tRNA ligase%3B LeuRS%3B class-I aminoacyl-tRNA synthetase%3B charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA%3B due to the large number of codons that tRNA(Leu) recognizes%2C the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA%2C but instead recognition is dependent on a conserved discriminator base A37 and a long arm%3B an editing domain hydrolyzes misformed products%3B in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase gene gene4 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00025 COSY_RS00030 COSY_0006 COSY_RS00030 8528 9505 - diguanylate cyclase gene gene5 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00030 COSY_RS00035 COSY_0007 COSY_RS00035 9545 10195 + ATP-dependent dethiobiotin synthetase BioD gene gene6 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00035 COSY_RS00040 COSY_0008 COSY_RS00040 10184 10522 - starvation protein B gene gene7 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00040 COSY_RS00045 COSY_0009 COSY_RS00045 10519 11154 - glutathione S-transferase gene gene8 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00045 COSY_RS00050 COSY_0010 COSY_RS00050 11193 11879 - ubiquinol-cytochrome C reductase gene gene9 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00050 COSY_RS00055 COSY_0011 COSY_RS00055 11884 13107 - cytochrome B gene gene10 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00055 COSY_RS00060 COSY_0012 COSY_RS00060 13121 13717 - ubiquinol-cytochrome C reductase gene gene11 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00060 COSY_RS00065 COSY_0013 COSY_RS00065 13826 14131 - hypothetical protein gene gene12 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00065 COSY_RS00070 COSY_0014 secA secA 14184 16877 + protein translocase subunit SecA functions in protein export%3B can interact with acidic membrane phospholipids and the SecYEG protein complex%3B binds to preproteins%3B binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein%3B ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane%3B additional proteins SecD/F/YajC aid SecA recycling%3B exists in an equilibrium between monomers and dimers%3B may possibly form higher order oligomers%3B proteins in this cluster correspond SecA1%3B SecA2 is not essential and seems to play a role in secretion of a subset of proteins gene gene13 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00070 COSY_RS00075 COSY_0015 COSY_RS00075 17357 18385 + dihydroorotase catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis gene gene14 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00075 COSY_RS00080 COSY_0016 COSY_RS00080 18778 19680 - bifunctional riboflavin biosynthesis protein RibF gene gene15 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00080 COSY_RS00085 COSY_0017 COSY_RS00085 19999 21054 - homoserine O-succinyltransferase gene gene16 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00085 COSY_RS00090 COSY_0018 COSY_RS00090 21054 21890 - hypothetical protein gene gene17 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00090 COSY_RS00095 COSY_0019 COSY_RS00095 21918 23105 - aspartate aminotransferase gene gene18 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00095 COSY_RS00100 COSY_0020 COSY_RS00100 23136 23462 - peptidylprolyl isomerase gene gene19 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00100 COSY_RS00105 COSY_0021 COSY_RS00105 23474 24268 - hypothetical protein gene gene20 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00105 COSY_RS00110 COSY_0022 COSY_RS00110 24280 25155 - phosphoribosylaminoimidazole-succinocarboxamide synthase catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis%3B SAICAR synthase gene gene21 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00110 COSY_RS00115 COSY_0023 COSY_RS00115 25265 25882 + hypothetical protein gene gene22 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00115 COSY_RS00120 COSY_0024 COSY_RS00120 25842 27014 - peptidase M23 gene gene23 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00120 COSY_RS00125 COSY_0025 COSY_RS00125 26989 28140 - 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzes the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate gene gene24 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00125 COSY_RS00130 COSY_0026 COSY_RS00130 28137 28937 - phosphatidate cytidylyltransferase gene gene25 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00130 COSY_RS00135 COSY_0027 COSY_RS00135 28948 29649 - UDP pyrophosphate synthase gene gene26 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00135 COSY_RS00140 COSY_0028 COSY_RS00140 29735 30502 + imidazole glycerol phosphate synthase subunit HisF gene gene27 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00140 COSY_RS00145 COSY_0029 COSY_RS00145 30571 31107 + membrane protein gene gene28 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00145 COSY_RS00150 COSY_0030 COSY_RS00150 31120 32013 + protoheme IX farnesyltransferase converts protoheme IX and farnesyl diphosphate to heme O gene gene29 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00150 COSY_RS00155 COSY_0031 COSY_RS00155 32014 32205 + hypothetical protein gene gene30 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00155 COSY_RS00160 COSY_0032 COSY_RS00160 32314 33288 - cytochrome oxidase assembly protein gene gene31 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00160 COSY_RS00165 COSY_0033 COSY_RS00165 33389 34216 - hypothetical protein gene gene32 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00165 COSY_RS00170 COSY_0034 COSY_RS00170 34428 35537 + cytochrome B559 subunit alpha gene gene33 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00170 COSY_RS00175 COSY_0035 COSY_RS00175 35563 37164 + cytochrome oxidase subunit I gene gene34 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00175 COSY_RS00180 COSY_0036 COSY_RS00180 37255 37788 + cytochrome C oxidase assembly protein gene gene35 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00180 COSY_RS00185 COSY_0037 COSY_RS00185 37806 38690 + MFS transporter gene gene36 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00185 COSY_RS00190 COSY_0038 COSY_RS00190 38756 38983 + hypothetical protein gene gene37 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00190 COSY_RS00195 COSY_0039 COSY_RS00195 38983 39681 + hypothetical protein gene gene38 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00195 COSY_RS00200 COSY_0040 COSY_RS00200 39798 41216 + cytochrome oxidase subunit I gene gene39 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00200 COSY_RS00205 COSY_0041 COSY_RS00205 41231 41962 + cytochrome oxidase subunit II gene gene40 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00205 COSY_RS00210 COSY_0043 COSY_RS00210 42121 43023 + cytochrome C oxidase subunit III gene gene41 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00210 COSY_RS00215 COSY_t01 COSY_RS00215 43138 43213 + tRNA-Thr tRNA gene42 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00215 COSY_RS00220 COSY_0044 COSY_RS00220 43633 44001 - hypothetical protein gene gene43 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00220 COSY_RS00225 COSY_0045 COSY_RS00225 44001 44201 - hypothetical protein gene gene44 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00225 COSY_RS00230 COSY_0046 COSY_RS00230 44194 46470 - cell division protein FtsK gene gene45 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00230 COSY_RS00235 COSY_0047 COSY_RS00235 46519 47463 + thioredoxin reductase catalyzes the transfer of electrons from NADPH to thioredoxin%3B FAD/NAD(P) binding gene gene46 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00235 COSY_RS00240 COSY_t02 COSY_RS00240 47513 47588 + tRNA-Phe tRNA gene47 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00240 COSY_RS00245 COSY_0049 pyrB pyrB 48071 49033 - aspartate carbamoyltransferase catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis gene gene48 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00245 COSY_RS00250 COSY_0050 COSY_RS00250 49014 49442 - Holliday junction DNA helicase gene gene49 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00250 COSY_RS00260 COSY_0053 COSY_RS00260 50625 51548 + thiamine biosynthesis protein ApbE gene gene52 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00260 COSY_RS00265 COSY_0054 COSY_RS00265 52239 52631 + camphor resistance protein CrcB gene gene53 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00265 COSY_RS00270 COSY_0055 COSY_RS00270 52628 53590 - glutathione synthetase catalyzes the second step in the glutathione biosynthesis pathway%2C where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine %3D ADP + phosphate + glutathione gene gene54 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00270 COSY_RS00275 COSY_t03 COSY_RS00275 53629 53705 + tRNA-Met tRNA gene55 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00275 COSY_RS00280 COSY_0057 COSY_RS00280 53808 54269 + ribosome maturation factor RimP gene gene56 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00280 COSY_RS00285 COSY_0058 nusA nusA 54310 55785 + transcription termination factor NusA modifies transcription through interactions with RNA polymerase affecting elongation%2C readthrough%2C termination%2C and antitermination gene gene57 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00285 COSY_RS00290 COSY_0059 COSY_RS00290 55839 58286 + translation initiation factor IF-2 gene gene58 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00290 COSY_RS00295 COSY_0060 COSY_RS00295 58301 58645 + ribosome-binding factor A gene gene59 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00295 COSY_RS00300 COSY_0061 COSY_RS00300 58668 59576 + tRNA pseudouridine synthase B gene gene60 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00300 COSY_RS00305 COSY_0062 COSY_RS00305 59816 61099 + phosphoribosylamine--glycine ligase catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis gene gene61 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00305 COSY_RS00310 COSY_0063 COSY_RS00310 61656 62363 - hypothetical protein gene gene62 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00310 COSY_RS00315 COSY_0064 COSY_RS00315 62682 63512 + 16S rRNA (cytidine(1402)-2'-O)-methyltransferase gene gene63 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00315 COSY_RS00320 COSY_0065 COSY_RS00320 63752 64357 - dephospho-CoA kinase gene gene64 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00320 COSY_RS00325 COSY_t04 COSY_RS00325 64442 64518 + tRNA-Met tRNA gene65 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00325 COSY_RS00330 COSY_0067 COSY_RS00330 65198 65623 - nuclease gene gene66 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00330 COSY_RS00335 COSY_0068 COSY_RS00335 66489 66692 - hypothetical protein gene gene67 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00335 COSY_RS00340 COSY_0069 COSY_RS00340 68273 68479 - hypothetical protein gene gene68 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00340 COSY_RS00345 COSY_0070 COSY_RS00345 69410 71395 + transketolase catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate%3B can transfer ketol groups between several groups%3B in Escherichia coli there are two tkt genes%2C tktA expressed during exponential growth and the tktB during stationary phase gene gene69 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00345 COSY_RS00350 COSY_0071 COSY_RS00350 71501 72496 + glyceraldehyde-3-phosphate dehydrogenase gene gene70 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00350 COSY_RS00355 COSY_0072 COSY_RS00355 72944 74122 + phosphoglycerate kinase gene gene71 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00355 COSY_RS00360 COSY_0073 COSY_RS00360 74115 75557 + pyruvate kinase catalyzes the formation of phosphoenolpyruvate from pyruvate gene gene72 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00360 COSY_RS00365 COSY_0074 COSY_RS00365 75633 76694 + fructose-bisphosphate aldolase class II aldolase%3B catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle%2C glycolysis and gluconeogenesis gene gene73 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00365 COSY_RS00370 COSY_0075 gidA gidA 76761 78626 + tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG GidA%3B glucose-inhibited cell division protein A%3B involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs gene gene74 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00370 COSY_RS00375 COSY_0076 COSY_RS00375 78995 79795 + hypothetical protein gene gene75 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00375 COSY_RS00380 COSY_0077 COSY_RS00380 79802 80572 + DNAase gene gene76 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00380 COSY_RS00385 COSY_0078 COSY_RS00385 80569 81480 + 23S rRNA pseudouridylate synthase C gene gene77 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00385 COSY_RS00390 COSY_0079 ubiA ubiA 81477 82346 + 4-hydroxybenzoate polyprenyltransferase catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate%2C as part of the ubiquinone biosynthesis pathway gene gene78 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00390 COSY_RS00395 COSY_0080 dapD dapD 82865 83680 - 2%2C3%2C4%2C5-tetrahydropyridine-2%2C6-carboxylate N-succinyltransferase catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway gene gene79 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00395 COSY_RS00400 COSY_0081 COSY_RS00400 83842 85236 + 4Fe-4S ferredoxin gene gene80 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00400 COSY_RS00405 COSY_0082 COSY_RS00405 85236 85715 + hypothetical protein gene gene81 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00405 COSY_RS00410 COSY_0083 znuC znuC 86107 86826 - Mn2+/Zn2+ABC transporter ATP-binding protein involved in transport of zinc(II) with ZnuA and C gene gene82 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00410 COSY_RS00415 COSY_0084 COSY_RS00415 86918 89647 + DNA polymerase I has 3'-5' exonuclease%2C 5'-3' exonuclease and 5'-3'polymerase activities%2C primarily functions to fill gaps during DNA replication and repair gene gene83 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00415 COSY_RS00420 COSY_0085 argS argS 90504 92222 + arginine--tRNA ligase catalyzes a two-step reaction%2C first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B class-I aminoacyl-tRNA synthetase gene gene84 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00420 COSY_RS00425 COSY_0086 COSY_RS00425 92219 95389 + DNA helicase UvrD gene gene85 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00425 COSY_RS00430 COSY_0087 COSY_RS00430 96260 96841 - thiamine-phosphate diphosphorylase gene gene86 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00430 COSY_RS00435 COSY_0088 COSY_RS00435 96753 97796 + LPS export ABC transporter periplasmic protein LptC gene gene87 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00435 COSY_RS00440 COSY_0089 sat sat 98093 99301 + sulfate adenylyltransferase ATP sulfurylase%3B ATPS%3B converts ATP and sulfate to 5'phosphosulfate and pyrophosphate%3B in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction%3B the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms gene gene88 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00440 COSY_RS00445 COSY_0090 COSY_RS00445 99516 100385 + adenylylsulfate reductase membrane anchor gene gene89 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00445 COSY_RS00450 COSY_0091 COSY_RS00450 100417 100896 + adenylylsulfate reductase subunit beta gene gene90 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00450 COSY_RS00455 COSY_0092 COSY_RS00455 100896 102779 + adenylylsulfate reductase subunit alpha catalyzes the reduction of adenosine 5'-phosphosulfate to AMP and sulfite gene gene91 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00455 COSY_RS00460 COSY_0093 COSY_RS00460 102890 103240 + hypothetical protein gene gene92 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00460 COSY_RS00465 COSY_0094 COSY_RS00465 103246 103752 + peptidyl-prolyl cis-trans isomerase gene gene93 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00465 COSY_RS00470 COSY_0095 COSY_RS00470 103755 104108 + hypothetical protein gene gene94 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00470 COSY_RS00475 COSY_0096 hppA hppA 104183 106183 - potassium transporter pyrophosphate-energized proton pump%3B pyrophosphate-energized inorganic pyrophosphatase%3B H+-PPase%3B can cleave pyrophosphate to two phosphates%3B can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient gene gene95 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00475 COSY_RS00480 COSY_0097 COSY_RS00480 106680 107339 - adenylate kinase gene gene96 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00480 COSY_RS00485 COSY_0098 COSY_RS00485 107449 108693 - 6-phosphofructokinase catalyzes the formation of D-fructose 1%2C6-bisphosphate from D-fructose 6-phosphate in glycolysis gene gene97 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00485 COSY_RS00490 COSY_0099 COSY_RS00490 108746 109228 - phosphodiesterase gene gene98 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00490 COSY_RS00495 COSY_0100 COSY_RS00495 109916 111304 - cysteinyl-tRNA synthetase gene gene99 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00495 COSY_RS00500 COSY_0101 COSY_RS00500 111445 112044 + peroxidase gene gene100 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00500 COSY_RS00505 COSY_0102 COSY_RS00505 112098 112262 + rubredoxin gene gene101 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00505 COSY_RS00510 COSY_0103 COSY_RS00510 112298 113368 + 3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis gene gene102 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00510 COSY_RS00515 COSY_0104 COSY_RS00515 114386 115339 - hypothetical protein gene gene103 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00515 COSY_RS00520 COSY_0105 COSY_RS00520 115792 116337 + ADP-ribose diphosphatase gene gene104 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00520 COSY_RS00525 COSY_0106 COSY_RS00525 117062 118303 + diaminopimelate decarboxylase gene gene105 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00525 COSY_RS00530 COSY_0107 COSY_RS00530 118296 118598 + RNA-binding protein RNA binding protein found associated to pre-50S subunit of the ribosome%3B putative role in ribosome assembly%3B necessary for optimal growth but not cell viability gene gene106 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00530 COSY_RS00535 COSY_0108 COSY_RS00535 118605 119690 + lipid-A-disaccharide synthase gene gene107 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00535 COSY_RS00540 COSY_0109 COSY_RS00540 119671 120504 + nicotinate-nucleotide pyrophosphorylase catalyzes the formation of pyridine-2%2C3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide gene gene108 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00540 COSY_RS00545 COSY_0110 COSY_RS00545 120490 121251 - inositol monophosphatase gene gene109 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00545 COSY_RS00550 COSY_t05 COSY_RS00550 121650 121726 - tRNA-Met tRNA gene110 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00550 COSY_RS00555 COSY_0112 COSY_RS00555 121734 123545 - RNA polymerase sigma factor RpoD gene gene111 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00555 COSY_RS00560 COSY_0113 COSY_RS00560 123645 124598 - ribose-phosphate pyrophosphokinase catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP gene gene112 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00560 COSY_RS00565 COSY_t06 COSY_RS00565 124668 124742 - tRNA-Gln tRNA gene113 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00565 COSY_RS00570 COSY_0116 COSY_RS00570 125572 126117 - oligoribonuclease gene gene114 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00570 COSY_RS00575 COSY_0117 trpD trpD 126130 127149 - anthranilate phosphoribosyltransferase Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate gene gene115 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00575 COSY_RS00580 COSY_0118 COSY_RS00580 127154 128371 - peptidase M24 gene gene116 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00580 COSY_RS00585 COSY_0119 COSY_RS00585 128425 129141 + hypothetical protein gene gene117 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00585 COSY_RS00590 COSY_0120 COSY_RS00590 129127 130185 - hypothetical protein gene gene118 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00590 COSY_RS00595 COSY_0121 COSY_RS00595 130460 131287 - pyrroline-5-carboxylate reductase gene gene119 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00595 COSY_RS00600 COSY_0122 COSY_RS00600 131363 132031 + phosphoglycolate phosphatase gene gene120 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00600 COSY_RS00605 COSY_0123 COSY_RS00605 132059 133297 + adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA gene gene121 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00605 COSY_RS00610 COSY_0124 COSY_RS00610 134198 136204 - primosomal protein N' gene gene122 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00610 COSY_RS00615 COSY_0125 COSY_RS00615 136268 136705 + endoribonuclease YbeY gene gene123 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00615 COSY_RS00620 COSY_0126 COSY_RS00620 136759 137931 - tRNA(Ile)-lysidine synthetase gene gene124 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00620 COSY_RS00625 COSY_0127 COSY_RS00625 137912 138880 - acetyl-CoA carboxylase carboxyltransferase subunit alpha catalyzes the carboxylation of acetyl-CoA to malonyl-CoA%3B forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits%3B one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein gene gene125 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00625 COSY_RS00630 COSY_RS00630 COSY_RS00630 139149 139346 + cbb3-type cytochrome oxidase maturation protein gene gene126 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00630 COSY_RS00635 COSY_0129 COSY_RS00635 139384 140061 + hypothetical protein gene gene127 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00635 COSY_RS00640 COSY_0130 COSY_RS00640 140073 141353 + phosphate permease gene gene128 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00640 COSY_RS00645 COSY_0131 COSY_RS00645 141357 141587 + BolA family transcriptional regulator gene gene129 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00645 COSY_RS00650 COSY_0132 COSY_RS00650 141728 142996 + RNA helicase this helicase is not essential cell growth gene gene130 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00650 COSY_RS00655 COSY_0133 COSY_RS00655 143007 143252 + hypothetical protein gene gene131 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00655 COSY_RS00660 COSY_0134 COSY_RS00660 144020 145204 - tyrosyl-tRNA synthetase catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) gene gene132 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00660 COSY_RS00665 COSY_0135 COSY_RS00665 145210 146469 - gamma-glutamyl phosphate reductase gene gene133 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00665 COSY_RS00670 COSY_0136 COSY_RS00670 146457 147476 - DNA polymerase III subunit delta gene gene134 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00670 COSY_RS00675 COSY_0137 COSY_RS00675 147466 147912 - hypothetical protein gene gene135 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00675 COSY_RS00680 COSY_0138 hflB hflB 148068 149990 + ATP-dependent metalloprotease inner membrane metalloprotease%3B may be involved in degradation of aberrant cytoplasmic and membrane proteins gene gene136 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00680 COSY_RS00685 COSY_0139 folP folP 150044 150829 + dihydropteroate synthase catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7%2C8-dihydropteridine diphosphate and 4-aminobenzoate gene gene137 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00685 COSY_RS00690 COSY_0140 glmM glmM 150831 152156 + phosphoglucosamine mutase catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate gene gene138 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00690 COSY_RS00695 COSY_0141 COSY_RS00695 153241 153975 + permease gene gene139 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00695 COSY_RS00700 COSY_0142 COSY_RS00700 154174 154749 + electron transporter RsxE gene gene140 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00700 COSY_RS00705 COSY_0143 COSY_RS00705 154762 155301 + electron transporter RnfB gene gene141 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00705 COSY_RS00710 COSY_0144 COSY_RS00710 155304 156794 + electron transporter RnfC gene gene142 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00710 COSY_RS00715 COSY_0145 COSY_RS00715 156791 157735 + electron transporter RnfG gene gene143 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00715 COSY_RS00720 COSY_0146 COSY_RS00720 157738 158343 + electron transporter RnfG gene gene144 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00720 COSY_RS00725 COSY_0147 COSY_RS00725 158334 159356 + S-adenosylmethionine:tRNA ribosyltransferase-isomerase gene gene145 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00725 COSY_RS00730 COSY_0148 COSY_RS00730 159806 160576 - hypothetical protein gene gene146 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00730 COSY_RS00735 COSY_0149 COSY_RS00735 160573 161442 - succinyl-CoA synthetase subunit alpha Catalyzes the only substrate-level phosphorylation in the TCA cycle gene gene147 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00735 COSY_RS00740 COSY_0150 sucC sucC 161439 162599 - malate--CoA ligase subunit beta catalyzes the interconversion of succinyl-CoA and succinate gene gene148 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00740 COSY_RS00745 COSY_0151 COSY_RS00745 163299 163862 + elongation factor P gene gene149 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00745 COSY_RS00750 COSY_0152 COSY_RS00750 163919 164797 + tRNA synthetase gene gene150 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00750 COSY_RS00760 COSY_0154 COSY_RS00760 166998 168209 + argininosuccinate synthase gene gene152 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00760 COSY_RS00765 COSY_t07 COSY_RS00765 168277 168350 - tRNA-Cys tRNA gene153 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00765 COSY_RS00770 COSY_t08 COSY_RS00770 168402 168477 - tRNA-Gly tRNA gene154 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00770 COSY_RS00775 COSY_0157 COSY_RS00775 168538 169116 - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase gene gene155 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00775 COSY_RS00780 COSY_t09 COSY_RS00780 169152 169228 - tRNA-Arg tRNA gene156 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00780 COSY_RS00785 COSY_0159 COSY_RS00785 169282 170562 - UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase gene gene157 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00785 COSY_RS00790 COSY_0160 COSY_RS00790 171068 172462 - UDP-N-acetylmuramoylalanyl-D-glutamate--2%2C 6-diaminopimelate ligase gene gene158 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00790 COSY_RS00795 COSY_0161 COSY_RS00795 172596 174485 + 5'-nucleotidase gene gene159 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00795 COSY_RS00800 COSY_0163 COSY_RS00800 175535 176500 - D-arabinose 5-phosphate isomerase gene gene160 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00800 COSY_RS00805 COSY_0164 COSY_RS00805 176960 177334 + 30S ribosomal protein S12 gene gene161 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00805 COSY_RS00810 COSY_0165 COSY_RS00810 177367 177834 + 30S ribosomal protein S7 gene gene162 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00810 COSY_RS00815 COSY_0166 fusA fusA 177859 179961 + elongation factor G EF-G%3B promotes GTP-dependent translocation of the ribosome during translation%3B many organisms have multiple copies of this gene gene gene163 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00815 COSY_RS00820 COSY_0167 tuf tuf 179972 181162 + elongation factor Tu EF-Tu%3B promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B when the tRNA anticodon matches the mRNA codon%2C GTP hydrolysis results%3B the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts%3B many prokaryotes have two copies of the gene encoding EF-Tu gene gene164 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00820 COSY_RS00825 COSY_0168 rpsJ rpsJ 181250 181561 + 30S ribosomal protein S10 NusE%3B involved in assembly of the 30S subunit%3B in the ribosome%2C this protein is involved in the binding of tRNA%3B in Escherichia coli this protein was also found to be involved in transcription antitermination%3B NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination%3B binding of NusB/S10 to boxA nucleates assembly of the antitermination complex gene gene165 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00825 COSY_RS00830 COSY_0169 COSY_RS00830 181590 182315 + 50S ribosomal protein L3 gene gene166 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00830 COSY_RS00835 COSY_0170 rplD rplD 182329 182943 + 50S ribosomal protein L4 L4 is important during the early stages of 50S assembly%3B it initially binds near the 5' end of the 23S rRNA gene gene167 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00835 COSY_RS00840 COSY_0171 rplW rplW 182940 183230 + 50S ribosomal protein L23 binds third domain of 23S rRNA and protein L29%3B part of exit tunnel gene gene168 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00840 COSY_RS00845 COSY_0172 COSY_RS00845 183241 184071 + 50S ribosomal protein L2 gene gene169 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00845 COSY_RS00850 COSY_0173 COSY_RS00850 184076 184345 + 30S ribosomal protein S19 gene gene170 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00850 COSY_RS00855 COSY_0174 COSY_RS00855 184366 184698 + 50S ribosomal protein L22 gene gene171 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00855 COSY_RS00860 COSY_0175 COSY_RS00860 184706 185398 + 30S ribosomal protein S3 gene gene172 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00860 COSY_RS00865 COSY_0176 COSY_RS00865 185415 185825 + 50S ribosomal protein L16 gene gene173 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00865 COSY_RS00870 COSY_0177 COSY_RS00870 185825 186013 + 50S ribosomal protein L29 gene gene174 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00870 COSY_RS00875 COSY_0178 COSY_RS00875 186010 186276 + 30S ribosomal protein S17 gene gene175 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00875 COSY_RS00880 COSY_0179 COSY_RS00880 186305 186673 + 50S ribosomal protein L14 gene gene176 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00880 COSY_RS00885 COSY_0180 rplX rplX 186673 186984 + 50S ribosomal protein L24 assembly initiator protein%3B binds to 5' end of 23S rRNA and nucleates assembly of the 50S%3B surrounds polypeptide exit tunnel gene gene177 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00885 COSY_RS00890 COSY_0181 COSY_RS00890 187014 187553 + 50S ribosomal protein L5 gene gene178 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00890 COSY_RS00895 COSY_0182 COSY_RS00895 187559 187864 + 30S ribosomal protein S14 gene gene179 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00895 COSY_RS00900 COSY_0183 COSY_RS00900 187876 188271 + 30S ribosomal protein S8 gene gene180 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00900 COSY_RS00905 COSY_0184 COSY_RS00905 188287 188832 + 50S ribosomal protein L6 gene gene181 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00905 COSY_RS00910 COSY_0185 COSY_RS00910 188850 189197 + 50S ribosomal protein L18 gene gene182 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00910 COSY_RS00915 COSY_0186 COSY_RS00915 189240 189755 + 30S ribosomal protein S5 gene gene183 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00915 COSY_RS00920 COSY_0187 COSY_RS00920 189794 189997 + 50S ribosomal protein L30 gene gene184 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00920 COSY_RS00925 COSY_0188 COSY_RS00925 190011 190445 + 50S ribosomal protein L15 gene gene185 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00925 COSY_RS00930 COSY_0189 COSY_RS00930 190449 191747 + preprotein translocase subunit SecY gene gene186 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00930 COSY_RS00935 COSY_0190 rpmJ rpmJ 191762 191875 + 50S ribosomal protein L36 smallest protein in the large subunit%3B similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc%3B the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion%3B the proteins in this group have the motif gene gene187 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00935 COSY_RS00940 COSY_0191 COSY_RS00940 192035 192388 + 30S ribosomal protein S13 gene gene188 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00940 COSY_RS00945 COSY_0192 COSY_RS00945 192407 192793 + 30S ribosomal protein S11 gene gene189 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00945 COSY_RS00950 COSY_0193 COSY_RS00950 192803 193429 + 30S ribosomal protein S4 gene gene190 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00950 COSY_RS00955 COSY_0194 COSY_RS00955 193440 194420 + DNA-directed RNA polymerase subunit alpha catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme gene gene191 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00955 COSY_RS00960 COSY_0195 COSY_RS00960 194431 194826 + 50S ribosomal protein L17 gene gene192 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00960 COSY_RS00965 COSY_0196 COSY_RS00965 194838 195053 + 30S ribosomal protein S21 gene gene193 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00965 COSY_RS00970 COSY_0197 COSY_RS00970 195605 196669 + polynucleotide adenylyltransferase gene gene194 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00970 COSY_RS00975 COSY_0198 COSY_RS00975 196825 199299 - hypothetical protein gene gene195 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00975 COSY_RS00980 COSY_0199 COSY_RS00980 199289 199888 - GTP-binding protein gene gene196 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00980 COSY_RS00985 COSY_0200 COSY_RS00985 199963 200253 + cytochrome C gene gene197 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00985 COSY_RS00990 COSY_0201 COSY_RS00990 200362 201003 + cytochrome C gene gene198 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00990 COSY_RS00995 COSY_0202 COSY_RS00995 201131 202420 + trigger factor gene gene199 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS00995 COSY_RS01000 COSY_0203 COSY_RS01000 202425 203021 + ATP-dependent Clp protease proteolytic subunit gene gene200 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01000 COSY_RS01005 COSY_0204 clpX clpX 203026 204291 + ATP-dependent Clp protease ATP-binding subunit ClpX binds and unfolds substrates as part of the ClpXP protease gene gene201 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01005 COSY_RS01010 COSY_0205 COSY_RS01010 204729 207065 + peptidase gene gene202 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01010 COSY_RS01015 COSY_0206 COSY_RS01015 207072 207485 - hypothetical protein gene gene203 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01015 COSY_RS01020 COSY_0207 COSY_RS01020 208001 209440 + cytosol aminopeptidase gene gene204 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01020 COSY_RS01025 COSY_0208 COSY_RS01025 210371 210991 - hypothetical protein gene gene205 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01025 COSY_RS01030 COSY_0209 COSY_RS01030 211096 211500 - hypothetical protein gene gene206 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01030 COSY_RS01035 COSY_0210 COSY_RS01035 211500 211850 - nitrogen regulatory protein P-II gene gene207 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01035 COSY_RS01040 COSY_0211 COSY_RS01040 211859 212599 - membrane protein gene gene208 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01040 COSY_RS01045 COSY_0212 COSY_RS01045 212596 213327 - membrane protein gene gene209 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01045 COSY_RS01050 COSY_0213 COSY_RS01050 213433 214320 + aminodeoxychorismate lyase gene gene210 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01050 COSY_RS01055 COSY_0214 COSY_RS01055 214675 215292 + thymidylate kinase gene gene211 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01055 COSY_RS01060 COSY_0215 COSY_RS01060 215289 216317 + DNA polymerase III subunit delta' gene gene212 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01060 COSY_RS01065 COSY_0216 COSY_RS01065 216332 217618 + glutamate-1-semialdehyde 2%2C1-aminomutase Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway gene gene213 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01065 COSY_RS01070 COSY_0217 COSY_RS01070 217973 218626 + phosphoserine phosphatase gene gene214 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01070 COSY_RS01075 COSY_0218 COSY_RS01075 218722 219237 - NADH dehydrogenase gene gene215 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01075 COSY_RS01080 COSY_0219 COSY_RS01080 219266 219490 - transcriptional regulator gene gene216 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01080 COSY_RS01085 COSY_0220 COSY_RS01085 220337 220999 - ribose-5-phosphate isomerase A catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway gene gene217 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01085 COSY_RS01090 COSY_0221 COSY_RS01090 221042 221632 + non-canonical purine NTP pyrophosphatase HAM1-like protein%3B Rec-dependent growth%3B RgdB%3B yggV%3B it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine gene gene218 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01090 COSY_RS01095 COSY_0222 COSY_RS01095 221632 222750 + HemN family oxidoreductase gene gene219 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01095 COSY_RS01100 COSY_0223 COSY_RS01100 223648 224577 + acetylglutamate kinase catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate gene gene220 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01100 COSY_RS01105 COSY_0224 COSY_RS01105 224564 225421 + oxidoreductase gene gene221 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01105 COSY_RS01110 COSY_0225 COSY_RS01110 225415 226056 + YggS family pyridoxal phosphate enzyme gene gene222 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01110 COSY_RS01115 COSY_0226 COSY_RS01115 226236 226721 + asparaginase gene gene223 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01115 COSY_RS01120 COSY_0227 COSY_RS01120 227077 229551 + membrane protein gene gene224 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01120 COSY_RS01125 COSY_0228 tldD tldD 229536 230975 + protease TldD responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17%2C an exported protein that targets the essential topoisomerase II DNA gyrase%3B degrades the E. coli plasmid F-encoded CcdA gene gene225 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01125 COSY_RS01130 COSY_0229 COSY_RS01130 231072 231428 + NADH:ubiquinone oxidoreductase subunit A gene gene226 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01130 COSY_RS01135 COSY_0230 COSY_RS01135 231432 231911 + NADH-quinone oxidoreductase subunit B The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen gene gene227 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01135 COSY_RS01140 COSY_0231 COSY_RS01140 231911 232525 + NADH-quinone oxidoreductase subunit C gene gene228 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01140 COSY_RS01145 COSY_0232 COSY_RS01145 232527 233780 + NADH-quinone oxidoreductase subunit D Catalyzes the transfer of electrons from NADH to quinone gene gene229 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01145 COSY_RS01150 COSY_0233 COSY_RS01150 233777 234250 + NADH dehydrogenase subunit E gene gene230 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01150 COSY_RS01155 COSY_0234 COSY_RS01155 234247 235515 + NADH dehydrogenase part of NADH-ubiquinone oxidoreductase complex I%3B shuttles electrons from NADH%2C via FMN and iron-sulfur (Fe-S) centers%2C to quinones in the respiratory chain%3B NuoF is part of the soluble NADH dehydrogenase fragment%2C which represents the electron input part of NADH dehydrogenase gene gene231 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01155 COSY_RS01160 COSY_0235 COSY_RS01160 235520 237781 + NADH-quinone oxidoreductase gene gene232 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01160 COSY_RS01165 COSY_0236 COSY_RS01165 237781 238854 + NADH-quinone oxidoreductase subunit H Catalyzes the transfer of electrons from NADH to quinone gene gene233 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01165 COSY_RS01170 COSY_0237 COSY_RS01170 238868 239359 + NADH-quinone oxidoreductase subunit I gene gene234 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01170 COSY_RS01175 COSY_0238 COSY_RS01175 239432 239980 + NADH:ubiquinone oxidoreductase subunit J gene gene235 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01175 COSY_RS01180 COSY_0239 COSY_RS01180 239981 240286 + NADH-quinone oxidoreductase subunit K gene gene236 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01180 COSY_RS01185 COSY_0240 COSY_RS01185 240289 242250 + NADH:ubiquinone oxidoreductase subunit L gene gene237 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01185 COSY_RS01190 COSY_0241 COSY_RS01190 242253 243758 + NADH:ubiquinone oxidoreductase subunit M Catalyzes the transfer of electrons from NADH to quinone gene gene238 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01190 COSY_RS01195 COSY_0242 COSY_RS01195 243769 245223 + NADH:ubiquinone oxidoreductase subunit N gene gene239 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01195 COSY_RS01200 COSY_0243 COSY_RS01200 245348 246136 - malonyl-[acyl-carrier protein] O-methyltransferase BioC gene gene240 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01200 COSY_RS01205 COSY_0244 COSY_RS01205 246124 247002 - ABC transporter substrate-binding protein gene gene241 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01205 COSY_RS01210 COSY_RS01210 COSY_RS01210 247961 248344 + hypothetical protein gene gene242 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01210 COSY_RS01215 COSY_0246 COSY_RS01215 248413 248970 - ribosome-recycling factor gene gene243 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01215 COSY_RS01220 COSY_0247 COSY_RS01220 248974 249687 - uridylate kinase gene gene244 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01220 COSY_RS01225 COSY_0248 COSY_RS01225 249770 252586 + excinuclease ABC subunit A gene gene245 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01225 COSY_RS01230 COSY_0249 purN purN 253046 253657 - phosphoribosylglycinamide formyltransferase glycinamide ribonucleotide transformylase%3B GAR Tfase%3B catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate%3B PurN requires formyl folate for the reaction unlike PurT which uses formate gene gene246 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01230 COSY_RS01235 COSY_0250 COSY_RS01235 253673 254674 - phosphoribosylaminoimidazole synthetase catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis gene gene247 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01235 COSY_RS01240 COSY_0251 COSY_RS01240 254728 255294 + CDP-alcohol phosphatidyltransferase gene gene248 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01240 COSY_RS01245 COSY_0252 COSY_RS01245 255291 255965 + DnaA family protein gene gene249 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01245 COSY_RS01250 COSY_0253 COSY_RS01250 255962 256369 - hypothetical protein gene gene250 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01250 COSY_RS01255 COSY_0254 COSY_RS01255 256466 257866 + siroheme synthase gene gene251 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01255 COSY_RS01260 COSY_0255 COSY_RS01260 257902 258105 - membrane protein gene gene252 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01260 COSY_RS01265 COSY_t10 COSY_RS01265 258203 258287 + tRNA-Leu tRNA gene253 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01265 COSY_RS01270 COSY_0257 COSY_RS01270 258304 259113 + phosphoserine phosphatase gene gene254 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01270 COSY_RS01275 COSY_0258 COSY_RS01275 259120 261027 + heme lyase subunit CcmF cytochrome c-type biogenesis protein%3B required for the transfer of heme to apocytochrome c gene gene255 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01275 COSY_RS01280 COSY_0259 COSY_RS01280 261024 262190 + hypothetical protein gene gene256 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01280 COSY_RS01285 COSY_0260 COSY_RS01285 262195 263325 + succinyl-diaminopimelate desuccinylase dapE-encoded N-succinyl-L%2CL-diaminopimelic acid desuccinylase (DapE)%2C catalyzes the hydrolysis of N-succinyl-L%2CLdiaminopimelate L%2CL-SDAP to L%2CL-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. gene gene257 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01285 COSY_RS01290 COSY_0261 trmD trmD 263329 264003 + tRNA (guanine(37)-N(1))-methyltransferase methylates guanosine-37 in various tRNAs%3B uses S-adenosyl-L-methionine to transfer methyl group to tRNA gene gene258 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01290 COSY_RS01295 COSY_0262 COSY_RS01295 264163 264501 + nitrogen regulatory protein P-II 1 indirectly regulates nitrogen metabolism%3B at high nitrogen levels P-II prevents the phosphorylation of NR-I%2C the transcriptional activator of the glutamine synthetase gene (glnA)%3B at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA gene gene259 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01295 COSY_RS01300 COSY_0263 COSY_RS01300 264491 265786 + ammonium transporter gene gene260 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01300 COSY_RS01305 COSY_0264 COSY_RS01305 265930 266790 + 4-hydroxy-tetrahydrodipicolinate synthase gene gene261 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01305 COSY_RS01310 COSY_0265 COSY_RS01310 266793 267926 + hypothetical protein gene gene262 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01310 COSY_RS01315 COSY_0266 COSY_RS01315 267941 269839 + DNA ligase gene gene263 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01315 COSY_RS01320 COSY_0267 COSY_RS01320 270118 270465 + nitrogen regulatory protein P-II 1 indirectly regulates nitrogen metabolism%3B at high nitrogen levels P-II prevents the phosphorylation of NR-I%2C the transcriptional activator of the glutamine synthetase gene (glnA)%3B at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA gene gene264 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01320 COSY_RS01330 COSY_0269 COSY_RS01330 271639 272079 + signal transduction protein gene gene266 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01330 COSY_RS01335 COSY_0270 COSY_RS01335 272076 272663 + chemotaxis protein CheY gene gene267 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01335 COSY_RS01340 COSY_0271 COSY_RS01340 272682 273503 - preprotein translocase subunit TatC with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane gene gene268 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01340 COSY_RS01345 COSY_0272 COSY_RS01345 273503 273784 - protein translocase TatA gene gene269 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01345 COSY_RS01350 COSY_0273 COSY_RS01350 273788 273997 - protein translocase TatA gene gene270 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01350 COSY_RS01355 COSY_0274 COSY_RS01355 274015 274332 - phosphoribosyl-ATP pyrophosphatase gene gene271 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01355 COSY_RS01360 COSY_0275 hisI hisI 274325 274705 - phosphoribosyl-AMP cyclohydrolase PR-AMP cyclohydrolase%3B functions in histidine biosynthesis from PRPP%3B converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxyamide during the histidine biosynthesis pathway%3B binds zinc and magnesium%3B forms homodimers gene gene272 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01360 COSY_RS01365 COSY_0276 COSY_RS01365 274829 276160 - glutathione reductase catalyzes the reduction of 2 glutathione to glutathione disulfide%3B maintains high levels of reduced glutathione in the cytosol%3B involved in redox regulation and oxidative defense gene gene273 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01365 COSY_RS01370 COSY_0277 COSY_RS01370 277039 277422 - hypothetical protein gene gene274 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01370 COSY_RS01375 COSY_0278 COSY_RS01375 277597 278691 - peptide chain release factor 2 gene gene275 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01375 COSY_RS01380 COSY_0279 COSY_RS01380 278763 279023 - 30S ribosomal protein S15 gene gene276 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01380 COSY_RS01385 COSY_0280 COSY_RS01385 279078 279974 - lipid A biosynthesis acyltransferase gene gene277 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01385 COSY_RS01390 COSY_0281 COSY_RS01390 280007 281791 + DNA primase gene gene278 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01390 COSY_RS01395 COSY_0282 COSY_RS01395 282020 282943 - ribosomal RNA small subunit methyltransferase H gene gene279 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01395 COSY_RS01400 COSY_0283 COSY_RS01400 282933 283340 - hypothetical protein gene gene280 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01400 COSY_RS01405 COSY_0284 COSY_RS01405 284122 286359 + DNA topoisomerase IV subunit A decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling gene gene281 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01405 COSY_RS01410 COSY_0285 COSY_RS01410 286461 286838 + 6-pyruvoyl tetrahydrobiopterin synthase gene gene282 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01410 COSY_RS01415 COSY_0286 COSY_RS01415 286835 287629 + GTP cyclohydrolase FolE2 similar protein in Methanocaldococcus converts GTP to 7%2C8-dihydro-D-neopterin 2'%2C3'-cyclic phosphate as the first step in methanopterin biosynthesis gene gene283 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01415 COSY_RS01420 COSY_0287 COSY_RS01420 287623 288690 + phospho-2-dehydro-3-deoxyheptonate aldolase gene gene284 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01420 COSY_RS01425 COSY_0288 COSY_RS01425 288802 291387 + DNA gyrase subunit A gene gene285 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01425 COSY_RS01430 COSY_0289 prfC prfC 291483 293054 - peptide chain release factor 3 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred%3B GDP/GTP-binding protein gene gene286 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01430 COSY_RS01435 COSY_0290 COSY_RS01435 293051 293497 - CMP deaminase gene gene287 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01435 COSY_RS01440 COSY_0291 COSY_RS01440 293500 294585 - phospho-N-acetylmuramoyl-pentapeptide transferase gene gene288 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01440 COSY_RS01445 COSY_0292 COSY_RS01445 295340 295573 + ferredoxin gene gene289 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01445 COSY_RS01450 COSY_0293 COSY_RS01450 295767 296882 - alanine--glyoxylate aminotransferase gene gene290 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01450 COSY_RS01455 COSY_0294 COSY_RS01455 296934 298364 + FAD-binding protein gene gene291 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01455 COSY_RS01460 COSY_0295 COSY_RS01460 298364 298897 + dehydrogenase gene gene292 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01460 COSY_RS01465 COSY_0296 glcF glcF 298897 300021 + glycolate oxidase gene gene293 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01465 COSY_RS01470 COSY_0298 COSY_RS01470 300047 301366 + 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD gene gene294 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01470 COSY_RS01475 COSY_0300 COSY_RS01475 302211 302492 + hypothetical protein gene gene295 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01475 COSY_RS01480 COSY_0301 COSY_RS01480 302807 304960 - DNA helicase UvrD gene gene296 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01480 COSY_RS01485 COSY_0302 COSY_RS01485 305080 305265 + hypothetical protein gene gene297 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01485 COSY_RS01490 COSY_0303 COSY_RS01490 305270 306214 + L-lysine 2%2C3-aminomutase gene gene298 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01490 COSY_RS01495 COSY_0304 COSY_RS01495 306206 306727 - redoxin gene gene299 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01495 COSY_RS01500 COSY_0305 COSY_RS01500 306794 307141 + arsenate reductase gene gene300 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01500 COSY_RS01505 COSY_0306 COSY_RS01505 307171 307830 - glutathione S-transferase gene gene301 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01505 COSY_RS01510 COSY_0307 COSY_RS01510 308015 308647 - nicotinate-nucleotide adenylyltransferase gene gene302 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01510 COSY_RS01515 COSY_0308 COSY_RS01515 308651 309373 - MBL fold metallo-hydrolase gene gene303 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01515 COSY_RS01520 COSY_t11 COSY_RS01520 309468 309543 + tRNA-Ala tRNA gene304 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01520 COSY_RS01525 COSY_t12 COSY_RS01525 309560 309634 + tRNA-Glu tRNA gene305 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01525 COSY_RS01530 COSY_0311 COSY_RS01530 309885 310214 - hypothetical protein gene gene306 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01530 COSY_RS01535 COSY_0312 COSY_RS01535 310955 311899 + 23S rRNA pseudouridine synthase D gene gene307 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01535 COSY_RS01540 COSY_0313 COSY_RS01540 311951 312367 - repressor gene gene308 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01540 COSY_RS01545 COSY_0314 COSY_RS01545 312355 313164 - formamidopyrimidine-DNA glycosylase Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases gene gene309 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01545 COSY_RS01550 COSY_0315 COSY_RS01550 313319 313816 + membrane protein gene gene310 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01550 COSY_RS01555 COSY_0316 COSY_RS01555 314128 315183 + hypothetical protein gene gene311 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01555 COSY_RS01560 COSY_0317 COSY_RS01560 315362 316033 + hypothetical protein gene gene312 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01560 COSY_RS01565 COSY_0318 COSY_RS01565 316026 317396 + sodium:proton antiporter gene gene313 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01565 COSY_RS01570 COSY_0319 COSY_RS01570 317368 318087 + type III pantothenate kinase gene gene314 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01570 COSY_RS01575 COSY_0320 COSY_RS01575 318119 319315 + tryptophanyl-tRNA synthetase catalyzes a two-step reaction%2C first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA gene gene315 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01575 COSY_RS01580 COSY_0321 COSY_RS01580 319318 320043 + ribosomal large subunit pseudouridine synthase B gene gene316 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01580 COSY_RS01585 COSY_0322 ileS ileS 320193 323060 + isoleucine--tRNA ligase IleRS%3B catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile)%3B since isoleucine and other amino acids such as valine are similar%2C there are additional editing function in this enzyme%3B one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile)%3B there are two active sites%2C one for aminoacylation and one for editing%3B class-I aminoacyl-tRNA synthetase family type 1 subfamily%3B some organisms carry two different copies of this enzyme gene gene317 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01585 COSY_RS01590 COSY_0323 COSY_RS01590 323061 324143 + 3-dehydroquinate synthase gene gene318 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01590 COSY_RS01595 COSY_0324 COSY_RS01595 324150 324740 + hypothetical protein gene gene319 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01595 COSY_RS01600 COSY_0325 COSY_RS01600 324743 325030 + aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C gene gene320 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01600 COSY_RS01605 COSY_0326 COSY_RS01605 325032 326474 + glutamyl-tRNA(Gln) amidotransferase subunit A gene gene321 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01605 COSY_RS01610 COSY_0327 gatB gatB 326476 327906 + aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases%3B reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA gene gene322 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01610 COSY_RS01615 COSY_0328 COSY_RS01615 328729 329358 - peptidase M50 gene gene323 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01615 COSY_RS01620 COSY_0329 COSY_RS01620 329393 331075 + proline--tRNA ligase catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) gene gene324 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01620 COSY_RS01625 COSY_0330 COSY_RS01625 331130 331894 + phosphatidylserine decarboxylase gene gene325 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01625 COSY_RS01630 COSY_0331 COSY_RS01630 331869 333128 - cobalt transporter gene gene326 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01630 COSY_RS01635 COSY_0332 eno eno 333165 334451 - enolase catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis gene gene327 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01635 COSY_RS01640 COSY_0333 COSY_RS01640 335016 335279 + hypothetical protein gene gene328 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01640 COSY_RS01645 COSY_0334 COSY_RS01645 335919 338957 - acriflavin resistance protein gene gene329 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01645 COSY_RS01650 COSY_0335 COSY_RS01650 339045 340847 - GTP-binding protein gene gene330 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01650 COSY_RS01655 COSY_0336 COSY_RS01655 340918 341550 + ribosomal RNA large subunit methyltransferase E gene gene331 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01655 COSY_RS01660 COSY_0337 COSY_RS01660 341601 342572 + octaprenyl diphosphate synthase gene gene332 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01660 COSY_RS01665 COSY_0338 COSY_RS01665 342577 344637 + ATP-dependent DNA helicase DinG gene gene333 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01665 COSY_RS01670 COSY_0339 COSY_RS01670 344647 346095 - potassium transporter gene gene334 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01670 COSY_RS01675 COSY_0340 trkA trkA 346108 347481 - potassium transporter peripheral membrane protein involved in potassium uptake%3B found to be peripherally associated with the inner membrane in Escherichia coli%3B contains an NAD-binding domain gene gene335 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01675 COSY_RS01680 COSY_0341 COSY_RS01680 347488 348063 - histidine kinase gene gene336 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01680 COSY_RS01685 COSY_0342 COSY_RS01685 348076 350238 - two-component system sensor histidine kinase gene gene337 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01685 COSY_RS01690 COSY_0343 COSY_RS01690 350851 351381 + inorganic pyrophosphatase gene gene338 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01690 COSY_RS01695 COSY_0344 COSY_RS01695 351314 351952 + methyltransferase gene gene339 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01695 COSY_RS01700 COSY_0345 COSY_RS01700 351965 352441 + phosphopantetheine adenylyltransferase gene gene340 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01700 COSY_RS01705 COSY_0346 dnaK dnaK 352518 354422 + molecular chaperone DnaK heat shock protein 70%3B assists in folding of nascent polypeptide chains%3B refolding of misfolded proteins%3B utilizes ATPase activity to help fold%3B co-chaperones are DnaJ and GrpE%3B multiple copies in some bacteria gene gene341 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01705 COSY_RS01710 COSY_0347 COSY_RS01710 354494 355591 + molecular chaperone DnaJ chaperone Hsp40%3B co-chaperone with DnaK%3B Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins%2C also in an autonomous%2C dnaK-independent fashion gene gene342 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01710 COSY_RS01715 COSY_0348 COSY_RS01715 355980 356582 - ATP-dependent DNA helicase RuvA gene gene343 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01715 COSY_RS01720 COSY_0349 COSY_RS01720 356579 357193 - 3-isopropylmalate dehydratase small subunit gene gene344 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01720 COSY_RS01725 COSY_0350 COSY_RS01725 357194 358594 - 3-isopropylmalate dehydratase large subunit dehydratase component%2C catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate gene gene345 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01725 COSY_RS01730 COSY_0351 COSY_RS01730 358649 360421 + asparagine synthase gene gene346 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01730 COSY_RS01735 COSY_0352 COSY_RS01735 360414 360857 + RNase H gene gene347 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01735 COSY_RS01740 COSY_0353 COSY_RS01740 360984 361415 - hypothetical protein gene gene348 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01740 COSY_RS01745 COSY_0354 smpB smpB 361430 361915 + SsrA-binding protein binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes%3B also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site%3B SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus%3B both the tmRNA and SmpB are regulated in cell cycle-dependent manner%3B functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation gene gene349 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01745 COSY_RS01750 COSY_0355 COSY_RS01750 362435 362860 + nucleoside diphosphate kinase catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate gene gene350 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01750 COSY_RS01755 COSY_0356 COSY_RS01755 362910 363980 + 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN 23S rRNA m2A2503 methyltransferase%3B methylates the C2 position of the A2530 nucleotide in 23S rRNA%3B may be involved in antibiotic resistance gene gene351 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01755 COSY_RS01760 COSY_0357 COSY_RS01760 363964 364272 + hypothetical protein gene gene352 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01760 COSY_RS01765 COSY_0358 COSY_RS01765 364269 365345 + 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) gene gene353 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01765 COSY_RS01770 COSY_0359 COSY_RS01770 365332 365826 - ATP-binding protein gene gene354 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01770 COSY_RS01775 COSY_0360 COSY_RS01775 365823 367631 - 1-deoxy-D-xylulose-5-phosphate synthase catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate gene gene355 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01775 COSY_RS01780 COSY_0361 COSY_RS01780 367688 369043 - protease gene gene356 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01780 COSY_RS01785 COSY_0362 COSY_RS01785 369102 369689 + methyltransferase gene gene357 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01785 COSY_RS01790 COSY_0363 COSY_RS01790 369759 370088 + glutaredoxin gene gene358 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01790 COSY_RS01795 COSY_0364 COSY_RS01795 370160 373984 - phosphoribosylformylglycinamidine synthase gene gene359 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01795 COSY_RS01800 COSY_0365 COSY_RS01800 374121 374861 - transcriptional regulator gene gene360 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01800 COSY_RS01805 COSY_0366 COSY_RS01805 374890 375840 - quinolinate synthase 3 different subfamilies%3B catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate gene gene361 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01805 COSY_RS01810 COSY_0367 COSY_RS01810 375847 377598 - aspartyl-tRNA synthetase gene gene362 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01810 COSY_RS01815 COSY_0368 COSY_RS01815 377598 378209 - membrane protein gene gene363 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01815 COSY_RS01820 COSY_0369 COSY_RS01820 378266 379045 - methionine aminopeptidase catalyzes the removal of N-terminal amino acids from peptides and arylamides%3B generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn%2C Fe%2C or Mn gene gene364 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01820 COSY_RS01825 COSY_0370 COSY_RS01825 379036 380064 - peptidase M48 gene gene365 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01825 COSY_RS01830 COSY_0371 COSY_RS01830 380205 380813 - hypothetical protein gene gene366 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01830 COSY_RS01835 COSY_t13 COSY_RS01835 381581 381656 - tRNA-His tRNA gene367 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01835 COSY_RS01840 COSY_t14 COSY_RS01840 381679 381755 - tRNA-Arg tRNA gene368 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01840 COSY_RS01845 COSY_t15 COSY_RS01845 381806 381882 - tRNA-Pro tRNA gene369 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01845 COSY_RS01850 COSY_0375 COSY_RS01850 382510 383181 - DNA polymerase III subunit epsilon gene gene370 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01850 COSY_RS01855 COSY_0376 COSY_RS01855 383251 383583 + DNA-directed RNA polymerase subunit omega gene gene371 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01855 COSY_RS01860 COSY_0377 COSY_RS01860 385459 386118 - hypothetical protein gene gene372 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01860 COSY_RS01865 COSY_0378 COSY_RS01865 386160 387146 - delta-aminolevulinic acid dehydratase catalyzes the formation of porphobilinogen from 5-aminolevulinate gene gene373 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01865 COSY_RS01870 COSY_0379 COSY_RS01870 387191 389059 + phosphomethylpyrimidine synthase catalyzes the formation of 4-amino-2-methyl-5-phosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole and S-adenosyl-L-methionine in thiamine biosynthesis gene gene374 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01870 COSY_RS01875 COSY_0380 COSY_RS01875 389195 390445 - 3-deoxy-D-manno-octulosonic acid transferase gene gene375 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01875 COSY_RS01880 COSY_0381 COSY_RS01880 390499 391503 + GTPase Obg gene gene376 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01880 COSY_RS01885 COSY_0382 COSY_RS01885 391500 392270 + glutamate 5-kinase gene gene377 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01885 COSY_RS01890 COSY_0383 COSY_RS01890 392264 392737 + 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase gene gene378 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01890 COSY_RS01895 COSY_0384 panB panB 392734 393516 + 3-methyl-2-oxobutanoate hydroxymethyltransferase catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5%2C10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate gene gene379 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01895 COSY_RS01900 COSY_0385 COSY_RS01900 393516 394364 + pantothenate synthetase gene gene380 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01900 COSY_RS01905 COSY_0386 COSY_RS01905 394357 394935 + fe/S biogenesis protein nfuA gene gene381 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01905 COSY_RS01910 COSY_0387 COSY_RS01910 394980 395489 + hypothetical protein gene gene382 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01910 COSY_RS01915 COSY_0388 COSY_RS01915 395489 396418 + thiamine-monophosphate kinase gene gene383 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01915 COSY_RS01920 COSY_0389 COSY_RS01920 396455 396865 - molecular chaperone DnaK gene gene384 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01920 COSY_RS01925 COSY_0390 COSY_RS01925 396956 397717 + phosphatase gene gene385 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01925 COSY_RS01930 COSY_0391 COSY_RS01930 397701 398678 + threonine dehydratase gene gene386 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01930 COSY_RS01935 COSY_0392 COSY_RS01935 399912 401159 + isocitrate dehydrogenase Converts isocitrate to alpha ketoglutarate gene gene387 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01935 COSY_RS01940 COSY_RS01940 COSY_RS01940 401369 401596 + hypothetical protein gene gene388 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01940 COSY_RS01945 COSY_0393 COSY_RS01945 401846 402370 + hypothetical protein gene gene389 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01945 COSY_RS01950 COSY_t16 COSY_RS01950 402624 402699 + tRNA-Asn tRNA gene390 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01950 COSY_RS01955 COSY_RS01955 COSY_RS01955 403402 403590 + hypothetical protein gene gene391 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01955 COSY_RS01960 COSY_0395 COSY_RS01960 403766 405025 + hypothetical protein gene gene392 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01960 COSY_RS01965 COSY_0396 COSY_RS01965 405069 406247 - aspartate aminotransferase catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate gene gene393 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01965 COSY_RS01970 COSY_0397 COSY_RS01970 406724 407365 + 7-carboxy-7-deazaguanine synthase gene gene394 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01970 COSY_RS01975 COSY_0398 COSY_RS01975 407366 407890 - heat-shock protein Hsp20 gene gene395 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01975 COSY_RS01980 COSY_0399 COSY_RS01980 408137 409234 - chorismate synthase catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis gene gene396 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01980 COSY_RS01985 COSY_t17 COSY_RS01985 409726 409802 - tRNA-Arg tRNA gene397 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01985 COSY_RS01990 COSY_0401 COSY_RS01990 410000 410695 + orotidine 5'-phosphate decarboxylase gene gene398 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01990 COSY_RS01995 COSY_t18 COSY_RS01995 410715 410791 + tRNA-Val tRNA gene399 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS01995 COSY_RS02000 COSY_0403 COSY_RS02000 411117 412310 + hypothetical protein gene gene400 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02000 COSY_RS02005 COSY_0404 COSY_RS02005 412310 412948 + pyridoxine/pyridoxamine 5'-phosphate oxidase gene gene401 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02005 COSY_RS02010 COSY_0405 COSY_RS02010 412937 413740 - shikimate dehydrogenase (NADP+) gene gene402 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02010 COSY_RS02015 COSY_0406 COSY_RS02015 413763 415484 - ribonuclease gene gene403 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02015 COSY_RS02020 COSY_0407 COSY_RS02020 415824 416543 - pteridine reductase Involved in pteridine salvage and antifolate resistance gene gene404 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02020 COSY_RS02025 COSY_0408 COSY_RS02025 416558 417652 + hypothetical protein gene gene405 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02025 COSY_RS02030 COSY_0409 COSY_RS02030 417670 418464 + undecaprenyl-diphosphatase gene gene406 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02030 COSY_RS02035 COSY_0410 COSY_RS02035 420095 421006 + UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase gene gene407 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02035 COSY_RS02040 COSY_0411 COSY_RS02040 421071 422804 + acetolactate synthase catalyzes the formation of 2-acetolactate from pyruvate%2C leucine sensitive gene gene408 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02040 COSY_RS02045 COSY_0412 COSY_RS02045 422801 423298 + acetolactate synthase gene gene409 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02045 COSY_RS02050 COSY_0413 COSY_RS02050 423322 424326 + ketol-acid reductoisomerase catalyzes the formation of (R)-2%2C3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis gene gene410 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02050 COSY_RS02055 COSY_0414 COSY_RS02055 424377 425123 + CDP-diacylglycerol--serine O-phosphatidyltransferase gene gene411 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02055 COSY_RS02060 COSY_0415 COSY_RS02060 425300 426835 + 2-isopropylmalate synthase catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis gene gene412 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02060 COSY_RS02065 COSY_0416 COSY_RS02065 426832 427251 + hypothetical protein gene gene413 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02065 COSY_RS02070 COSY_0417 COSY_RS02070 427239 427931 + hypothetical protein gene gene414 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02070 COSY_RS02075 COSY_0418 COSY_RS02075 427928 428827 - ornithine carbamoyltransferase gene gene415 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02075 COSY_RS02080 COSY_0419 COSY_RS02080 428841 429998 - acetylornithine aminotransferase gene gene416 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02080 COSY_RS02085 COSY_0420 COSY_RS02085 430066 430269 - hypothetical protein gene gene417 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02085 COSY_RS02090 COSY_0421 COSY_RS02090 430426 430734 + ribosome hibernation promoting factor HPF YhbH%3B resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase%3B binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization)%3B seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing gene gene418 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02090 COSY_RS02095 COSY_0422 COSY_RS02095 430781 432112 + magnesium transporter gene gene419 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02095 COSY_RS02100 COSY_0423 COSY_RS02100 432432 433805 - phosphoglucomutase gene gene420 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02100 COSY_RS02105 COSY_0424 COSY_RS02105 433862 434230 + sigma-E factor regulatory protein RseC gene gene421 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02105 COSY_RS02110 COSY_0425 aceE aceE 434291 436942 + pyruvate dehydrogenase E1 component%3B part of pyruvate dehydrogenase%3B forms a complex with DlaT and LpdC gene gene422 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02110 COSY_RS02115 COSY_0426 COSY_RS02115 437037 439130 - polynucleotide phosphorylase/polyadenylase gene gene423 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02115 COSY_RS02120 COSY_0427 COSY_RS02120 439839 441299 - inosine-5-monophosphate dehydrogenase gene gene424 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02120 COSY_RS02125 COSY_0428 COSY_RS02125 441299 441958 - peptide-binding protein gene gene425 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02125 COSY_RS02130 COSY_0429 COSY_RS02130 441955 444702 - valine--tRNA ligase gene gene426 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02130 COSY_RS02135 COSY_0430 COSY_RS02135 445145 445450 - hypothetical protein gene gene427 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02135 COSY_RS02140 COSY_0431 COSY_RS02140 445443 447014 - DNA polymerase III subunit gamma/tau gene gene428 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02140 COSY_RS02145 COSY_0432 COSY_RS02145 448280 449059 - branched-chain amino acid--2-keto-4-methylthiobutyrate aminotransferase gene gene429 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02145 COSY_RS02150 COSY_0433 COSY_RS02150 449113 450240 - D-alanyl-D-alanine carboxypeptidase penicillin-binding protein 5%3B removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors gene gene430 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02150 COSY_RS02155 COSY_0434 COSY_RS02155 450774 451913 - cell wall shape-determining protein gene gene431 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02155 COSY_RS02160 COSY_0435 COSY_RS02160 451910 452272 - hypothetical protein gene gene432 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02160 COSY_RS02165 COSY_0436 COSY_RS02165 452355 452804 + hypothetical protein gene gene433 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02165 COSY_RS02170 COSY_0437 COSY_RS02170 452820 454184 + glutamyl-tRNA synthetase gene gene434 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02170 COSY_RS02175 COSY_0438 COSY_RS02175 454200 456719 + uridylyltransferase gene gene435 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02175 COSY_RS02180 COSY_0439 COSY_RS02180 456806 457132 + thioredoxin gene gene436 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02180 COSY_RS02185 COSY_0440 rho rho 457248 458510 + transcription termination factor Rho An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes gene gene437 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02185 COSY_RS02190 COSY_0441 COSY_RS02190 458647 459720 + permease gene gene438 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02190 COSY_RS02195 COSY_0442 COSY_RS02195 459862 460260 + NADPH-dependent 7-cyano-7-deazaguanine reductase gene gene439 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02195 COSY_RS02200 COSY_0443 COSY_RS02200 460269 461420 + poly(A) polymerase gene gene440 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02200 COSY_RS02205 COSY_0444 COSY_RS02205 461790 462014 + exodeoxyribonuclease 7 small subunit gene gene441 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02205 COSY_RS02210 COSY_0445 COSY_RS02210 462064 462918 + farnesyl-diphosphate synthase gene gene442 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02210 COSY_RS02215 COSY_0446 COSY_RS02215 462915 463859 - 3-oxoacyl-ACP synthase III FabH%3B beta-ketoacyl-acyl carrier protein synthase III%3B catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation%3B differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs gene gene443 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02215 COSY_RS02220 COSY_0447 COSY_RS02220 463852 464871 - phosphate acyltransferase gene gene444 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02220 COSY_RS02225 COSY_0448 rpmF rpmF 464877 465074 - 50S ribosomal protein L32 some L32 proteins have zinc finger motifs consisting of CXXC while others do not gene gene445 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02225 COSY_RS02230 COSY_0449 COSY_RS02230 465098 465592 - hypothetical protein gene gene446 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02230 COSY_RS02235 COSY_0450 COSY_RS02235 465805 466485 - acyl-phosphate glycerol 3-phosphate acyltransferase gene gene447 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02235 COSY_RS02240 COSY_0451 COSY_RS02240 467297 468049 + oxoacyl-ACP reductase gene gene448 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02240 COSY_RS02245 COSY_0452 COSY_RS02245 468163 468966 - inositol monophosphatase gene gene449 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02245 COSY_RS02250 COSY_0453 COSY_RS02250 468980 469723 + RNA methyltransferase gene gene450 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02250 COSY_RS02255 COSY_0454 COSY_RS02255 469761 471611 - chaperone protein HtpG molecular chaperone gene gene451 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02255 COSY_RS02260 COSY_RS02260 COSY_RS02260 471880 472059 + hypothetical protein gene gene452 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02260 COSY_RS02265 COSY_0455 COSY_RS02265 472193 472729 + hypothetical protein gene gene453 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02265 COSY_RS02270 COSY_0456 COSY_RS02270 472726 473652 + coproporphyrinogen III oxidase catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis gene gene454 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02270 COSY_RS02275 COSY_0457 COSY_RS02275 473642 473866 + recombinase gene gene455 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02275 COSY_RS02280 COSY_0458 glnA glnA 473999 475414 + glutamine synthetase forms a homododecamer%3B forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate%3B also functions in the assimilation of ammonia%3B highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues%3B addition of adenylyl groups results in inactivation of the enzyme gene gene456 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02280 COSY_RS02285 COSY_0459 COSY_RS02285 475512 476480 + biotin synthase catalyzes the formation of biotin from dethiobiotin gene gene457 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02285 COSY_RS02290 COSY_0460 COSY_RS02290 476443 477435 - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-UDP N-acetylglucosamine transferase gene gene458 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02290 COSY_RS02295 COSY_0461 COSY_RS02295 478303 479916 + heme ABC transporter ATP-binding protein gene gene459 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02295 COSY_RS02300 COSY_0462 COSY_RS02300 480049 480654 + riboflavin synthase subunit alpha gene gene460 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02300 COSY_RS02305 COSY_0463 COSY_RS02305 480638 481711 + 3%2C4-dihydroxy-2-butanone 4-phosphate synthase bifunctional enzyme DHBP synthase/GTP cyclohydrolase II-like protein%3B functions in riboflavin synthesis gene gene461 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02305 COSY_RS02310 COSY_0464 ribH ribH 481722 482225 + 6%2C7-dimethyl-8-ribityllumazine synthase RibE%3B 6%2C7-diimethyl-8-ribityllumazine synthase%3B DMRL synthase%3B lumazine synthase%3B beta subunit of riboflavin synthase%3B condenses 5-amino-6-(1'-D)-ribityl-amino-2%2C4(1H%2C3H)-pyrimidinedione with L-3%2C4-dihydrohy-2-butanone-4-phosphate to generate 6%2C6-dimethyl-8-lumazine (DMRL)%3B riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12)%3B involved in the last steps of riboflavin biosynthesis%3B forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli%3B in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not gene gene462 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02310 COSY_RS02315 COSY_0465 COSY_RS02315 482228 482653 + antitermination factor NusB gene gene463 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02315 COSY_RS02320 COSY_0466 COSY_RS02320 482789 486451 - methionine synthase gene gene464 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02320 COSY_RS02325 COSY_0467 COSY_RS02325 486758 487144 + hypothetical protein gene gene465 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02325 COSY_RS02330 COSY_0468 COSY_RS02330 487208 487705 - single-stranded DNA-binding protein gene gene466 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02330 COSY_RS02335 COSY_0469 COSY_RS02335 487720 488895 - MFS transporter gene gene467 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02335 COSY_RS02340 COSY_0470 COSY_RS02340 488914 489681 - membrane protein gene gene468 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02340 COSY_RS02345 COSY_0471 COSY_RS02345 489779 491881 + (p)ppGpp synthetase gene gene469 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02345 COSY_RS02350 COSY_0472 COSY_RS02350 491956 492150 + hypothetical protein gene gene470 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02350 COSY_RS02355 COSY_0473 COSY_RS02355 492147 493421 + protein TolB gene gene471 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02355 COSY_RS02360 COSY_0474 COSY_RS02360 493433 494002 + flagellar motor protein MotB gene gene472 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02360 COSY_RS02365 COSY_0475 COSY_RS02365 494009 494674 + hypothetical protein gene gene473 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02365 COSY_RS02370 COSY_0476 COSY_RS02370 494687 495976 + hypothetical protein gene gene474 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02370 COSY_RS02375 COSY_0477 COSY_RS02375 496092 497972 - NAD+ synthetase gene gene475 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02375 COSY_RS02380 COSY_0478 hemH hemH 498452 499435 + ferrochelatase protoheme ferro-lyase%3B catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme%3B involved in protoheme biosynthesis%3B in some organisms this protein is membrane-associated while in others it is cytosolic gene gene476 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02380 COSY_RS02385 COSY_0479 COSY_RS02385 499543 501819 + ribonucleotide-diphosphate reductase subunit alpha Catalyzes the rate-limiting step in dNTP synthesis gene gene477 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02385 COSY_RS02390 COSY_0480 COSY_RS02390 501835 502971 + ribonucleotide-diphosphate reductase subunit beta B2 or R2 protein%3B type 1a enzyme%3B catalyzes the rate-limiting step in dNTP synthesis%3B converts nucleotides to deoxynucleotides%3B forms a homodimer and then a multimeric complex with NrdA gene gene478 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02390 COSY_RS02395 COSY_0481 COSY_RS02395 502980 503243 + ferredoxin gene gene479 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02395 COSY_RS02400 COSY_0482 COSY_RS02400 503429 504097 - dUTPase gene gene480 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02400 COSY_RS02405 COSY_0483 COSY_RS02405 504370 504951 - ribonuclease T gene gene481 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02405 COSY_RS02410 COSY_0484 COSY_RS02410 504941 505366 - GCN5 family acetyltransferase gene gene482 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02410 COSY_RS02415 COSY_0485 COSY_RS02415 505443 507107 + dihydroxy-acid dehydratase catalyzes the dehydration of 2%2C3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis gene gene483 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02415 COSY_RS02420 COSY_0486 COSY_RS02420 507173 509290 - ribonuclease R gene gene484 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02420 COSY_RS02425 COSY_0487 COSY_RS02425 509294 510610 - adenylosuccinate synthetase catalyzes the formation of N6-(1%2C2%2C-dicarboxyethyl)-AMP from L-aspartate%2C inosine monophosphate and GTP in AMP biosynthesis gene gene485 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02425 COSY_RS02430 COSY_0488 COSY_RS02430 510637 511587 - ATP phosphoribosyltransferase gene gene486 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02430 COSY_RS02435 COSY_0489 COSY_RS02435 511600 512457 - membrane protease HflC gene gene487 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02435 COSY_RS02440 COSY_0490 COSY_RS02440 512457 513626 - membrane protein gene gene488 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02440 COSY_RS02445 COSY_0491 COSY_RS02445 513749 515980 + organic solvent tolerance protein gene gene489 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02445 COSY_RS02450 COSY_0492 COSY_RS02450 515970 516863 + peptidyl-prolyl cis-trans isomerase gene gene490 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02450 COSY_RS02455 COSY_0493 COSY_RS02455 516864 517607 + RNA methyltransferase gene gene491 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02455 COSY_RS02460 COSY_0494 COSY_RS02460 517828 519018 - hypothetical protein gene gene492 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02460 COSY_RS02465 COSY_0495 COSY_RS02465 519093 520133 - ATPase gene gene493 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02465 COSY_RS02470 COSY_0496 COSY_RS02470 520197 520475 + hypothetical protein gene gene494 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02470 COSY_RS02475 COSY_0497 COSY_RS02475 520479 521096 + octanoyltransferase gene gene495 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02475 COSY_RS02480 COSY_0498 COSY_RS02480 521074 522021 + lipoyl synthase catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group gene gene496 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02480 COSY_RS02485 COSY_0499 COSY_RS02485 522046 525492 - acriflavin resistance protein gene gene497 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02485 COSY_RS02490 COSY_0500 COSY_RS02490 525499 526674 - RND transporter gene gene498 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02490 COSY_RS02495 COSY_0501 pdxA pdxA 526875 527873 + 4-hydroxythreonine-4-phosphate dehydrogenase catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) gene gene499 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02495 COSY_RS02500 COSY_0502 COSY_RS02500 527863 528618 + dimethyladenosine transferase gene gene500 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02500 COSY_RS02505 COSY_0503 COSY_RS02505 528602 528973 + cobalt transporter gene gene501 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02505 COSY_RS02510 COSY_0504 COSY_RS02510 528973 529770 + diadenosine tetraphosphatase gene gene502 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02510 COSY_RS02515 COSY_0505 dapF dapF 529767 530582 - diaminopimelate epimerase involved in lysine biosynthesis%3B DAP epimerase%3B produces DL-diaminopimelate from LL-diaminopimelate gene gene503 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02515 COSY_RS02520 COSY_RS02520 COSY_RS02520 530910 531128 + hypothetical protein gene gene504 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02520 COSY_RS02525 COSY_0506 COSY_RS02525 532101 533438 + peptidase gene gene505 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02525 COSY_RS02530 COSY_0507 COSY_RS02530 533454 535745 + hypothetical protein gene gene506 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02530 COSY_RS02535 COSY_0508 COSY_RS02535 535784 536782 + UDP-3-O-acylglucosamine N-acyltransferase gene gene507 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02535 COSY_RS02540 COSY_0509 COSY_RS02540 536784 537227 + 3-hydroxyacyl-ACP dehydratase gene gene508 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02540 COSY_RS02545 COSY_0510 COSY_RS02545 537253 538044 + UDP-N-acetylglucosamine acyltransferase gene gene509 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02545 COSY_RS02550 COSY_0511 COSY_RS02550 538062 539588 + membrane protein gene gene510 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02550 COSY_RS02555 COSY_0512 COSY_RS02555 539588 539857 + iron transporter gene gene511 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02555 COSY_RS02560 COSY_0513 gmk gmk 539850 540461 + guanylate kinase Essential for recycling GMP and indirectly%2C cGMP gene gene512 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02560 COSY_RS02565 COSY_0514 COSY_RS02565 540511 541344 + RNA polymerase factor sigma-32 gene gene513 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02565 COSY_RS02570 COSY_0515 COSY_RS02570 541411 541698 + molecular chaperone GroES gene gene514 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02570 COSY_RS02575 COSY_0516 groEL groEL 541711 543354 + molecular chaperone GroEL 60 kDa chaperone family%3B promotes refolding of misfolded polypeptides especially under stressful conditions%3B forms two stacked rings of heptamers to form a barrel-shaped 14mer%3B ends can be capped by GroES%3B misfolded proteins enter the barrel where they are refolded when GroES binds%3B many bacteria have multiple copies of the groEL gene which are active under different environmental conditions%3B the B.japonicum protein in this cluster is expressed constitutively%3B in Rhodobacter%2C Corynebacterium and Rhizobium this protein is essential for growth gene gene515 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02575 COSY_RS02580 COSY_0517 COSY_RS02580 543491 544732 + hypothetical protein gene gene516 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02580 COSY_RS02585 COSY_0518 COSY_RS02585 544813 546693 + DNA topoisomerase IV subunit B decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling gene gene517 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02585 COSY_RS02590 COSY_0519 COSY_RS02590 546686 547378 + 7-cyano-7-deazaguanine synthase gene gene518 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02590 COSY_RS02595 COSY_0520 COSY_RS02595 547487 547711 + acyl carrier protein carries the fatty acid chain in fatty acid biosynthesis gene gene519 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02595 COSY_RS02600 COSY_0521 COSY_RS02600 547790 549031 + 3-oxoacyl-ACP synthase FabF%3B beta-ketoacyl-ACP synthase II%2C KASII%3B catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP%3B required for the elongation of short-chain unsaturated acyl-ACP gene gene520 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02600 COSY_RS02605 COSY_0522 COSY_RS02605 549089 549301 - hypothetical protein gene gene521 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02605 COSY_RS02610 COSY_0523 COSY_RS02610 549294 551228 - oligopeptidase A gene gene522 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02610 COSY_RS02615 COSY_t19 COSY_RS02615 551241 551329 - tRNA-Ser tRNA gene523 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02615 COSY_RS02620 COSY_0525 COSY_RS02620 551517 553154 - methionine--tRNA ligase gene gene524 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02620 COSY_RS02625 COSY_0526 COSY_RS02625 553236 554309 + ATP-binding protein gene gene525 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02625 COSY_RS02630 COSY_0527 COSY_RS02630 554560 554898 - (2Fe-2S) ferredoxin gene gene526 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02630 COSY_RS02635 COSY_0528 hscA hscA 554921 556765 - Chaperone protein HscA homolog involved in the maturation of iron-sulfur cluster-containing proteins gene gene527 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02635 COSY_RS02640 COSY_0529 COSY_RS02640 556781 557296 - molecular chaperone Hsc20 gene gene528 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02640 COSY_RS02645 COSY_0530 iscA iscA 557309 557632 - (Fe-S)-cluster assembly protein forms iron-sulfur clusters of ferredoxin [2FE-2S]%3B binds iron in the presence of the thioredoxin reductase system%3B forms homodimers and tetramers%3B similar to SufA protein gene gene529 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02645 COSY_RS02650 COSY_0531 COSY_RS02650 557639 558016 - Fe-S cluster assembly scaffold IscU gene gene530 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02650 COSY_RS02655 COSY_0532 COSY_RS02655 558084 559298 - cysteine desulfurase IscS gene gene531 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02655 COSY_RS02660 COSY_0533 COSY_RS02660 559301 559720 - transcriptional regulator gene gene532 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02660 COSY_RS02665 COSY_0534 COSY_RS02665 559803 560501 - serine acetyltransferase gene gene533 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02665 COSY_RS02670 COSY_0535 COSY_RS02670 560570 561430 - lipid A biosynthesis acyltransferase gene gene534 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02670 COSY_RS02675 COSY_0536 COSY_RS02675 561411 562151 - adenine nucleotide alpha hydrolase gene gene535 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02675 COSY_RS02680 COSY_0537 COSY_RS02680 562691 564061 - membrane protein gene gene536 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02680 COSY_RS02685 COSY_0538 COSY_RS02685 564058 564540 - shikimate kinase gene gene537 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02685 COSY_RS02690 COSY_0539 COSY_RS02690 564784 565713 - branched-chain amino acid aminotransferase catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids gene gene538 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02690 COSY_RS02695 COSY_0540 COSY_RS02695 565716 566939 - aspartokinase gene gene539 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02695 COSY_RS02700 COSY_0541 COSY_RS02700 567344 568591 + peptidase M48 gene gene540 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02700 COSY_RS02705 COSY_0542 COSY_RS02705 568654 568908 + hypothetical protein gene gene541 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02705 COSY_RS02710 COSY_0543 COSY_RS02710 568957 569862 + ribosome small subunit-dependent GTPase gene gene542 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02710 COSY_RS02715 COSY_0544 COSY_RS02715 570494 570871 - hypothetical protein gene gene543 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02715 COSY_RS02720 COSY_t20 COSY_RS02720 571185 571260 - tRNA-Lys tRNA gene544 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02720 COSY_RS02725 COSY_0546 COSY_RS02725 571354 571632 - DNA-binding protein gene gene545 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02725 COSY_RS02730 COSY_0547 rpsA rpsA 571665 573344 - 30S ribosomal protein S1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit%3B autoregulates expression via a C-terminal domain%3B in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats%3B the S1 nucleic acid-binding domain is found associated with other proteins gene gene546 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02730 COSY_RS02735 COSY_0548 COSY_RS02735 573443 574120 - cytidylate kinase gene gene547 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02735 COSY_RS02740 COSY_0549 COSY_RS02740 574394 575884 - lysine--tRNA ligase gene gene548 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02740 COSY_RS02745 COSY_0550 COSY_RS02745 576514 576948 - cytochrome C biogenesis protein gene gene549 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02745 COSY_RS02750 COSY_0551 COSY_RS02750 576987 578603 + ABC transporter ATP-binding protein Uup%3B in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity%3B mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth gene gene550 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02750 COSY_RS02755 COSY_0552 COSY_RS02755 578739 579359 + hypothetical protein gene gene551 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02755 COSY_RS02760 COSY_RS02760 COSY_RS02760 579676 579885 - hypothetical protein gene gene552 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02760 COSY_RS02765 COSY_RS02765 COSY_RS02765 580355 580546 - hypothetical protein gene gene553 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02765 COSY_RS02770 COSY_0553 COSY_RS02770 580876 581526 + toluene tolerance protein gene gene554 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02770 COSY_RS02775 COSY_0554 COSY_RS02775 581526 582785 + UDP-N-acetylglucosamine 1-carboxyvinyltransferase adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation%3B gram-positive bacteria have 2 copies of MurA which are active gene gene555 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02775 COSY_RS02780 COSY_0555 hisG hisG 582792 583409 + ATP phosphoribosyltransferase short form of enzyme%3B requires HisZ for function%3B catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate%3B crucial role in histidine biosynthesis%3B forms heteromultimer of HisG and HisZ gene gene556 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02780 COSY_RS02785 COSY_0556 COSY_RS02785 583406 584701 + histidinol dehydrogenase gene gene557 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02785 COSY_RS02790 COSY_0557 COSY_RS02790 584810 586210 - signal recognition particle protein gene gene558 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02790 COSY_RS02795 COSY_0558 COSY_RS02795 586273 587052 + cytochrome C biogenesis protein gene gene559 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02795 COSY_RS02800 COSY_0559 COSY_RS02800 587509 589296 - elongation factor 4 gene gene560 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02800 COSY_RS02805 COSY_0560 COSY_RS02805 589337 589786 + peroxiredoxin gene gene561 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02805 COSY_RS02810 COSY_0561 COSY_RS02810 589780 590481 + 3-demethylubiquinone-9 3-methyltransferase gene gene562 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02810 COSY_RS02815 COSY_0562 COSY_RS02815 590517 590822 + hypothetical protein gene gene563 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02815 COSY_RS02820 COSY_0563 COSY_RS02820 590819 591202 - holo-ACP synthase gene gene564 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02820 COSY_RS02825 COSY_0564 COSY_RS02825 591199 591924 - pyridoxine 5'-phosphate synthase involved in the de novo synthesis of pyridoxine (Vitamin B6) gene gene565 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02825 COSY_RS02830 COSY_0565 COSY_RS02830 592352 593266 - GTPase Era gene gene566 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02830 COSY_RS02835 COSY_0566 rnc rnc 593263 593928 - ribonuclease III cytoplasmic enzyme involved in processing rRNA and some mRNAs%3B substrates typically have dsRNA regions%3B forms a homodimer%3B have N-terminal nuclease and C-terminal RNA-binding domains%3B requires magnesium as preferred ion for activity gene gene567 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02835 COSY_RS02840 COSY_0567 COSY_RS02840 593999 594661 + hypothetical protein gene gene568 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02840 COSY_RS02845 COSY_0568 COSY_RS02845 594979 595773 - thymidylate synthase gene gene569 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02845 COSY_RS02850 COSY_0569 COSY_RS02850 595770 596555 - prolipoprotein diacylglyceryl transferase transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein gene gene570 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02850 COSY_RS02855 COSY_t21 COSY_RS02855 596571 596647 - tRNA-Arg tRNA gene571 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02855 COSY_RS02860 COSY_0571 COSY_RS02860 596667 596978 - ArsR family transcriptional regulator gene gene572 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02860 COSY_RS02865 COSY_0572 COSY_RS02865 596985 597569 - hypothetical protein gene gene573 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02865 COSY_RS02870 COSY_0573 COSY_RS02870 597670 599001 + peptidase S41 gene gene574 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02870 COSY_RS02875 COSY_0574 COSY_RS02875 599452 600336 - signal peptidase gene gene575 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02875 COSY_RS02880 COSY_0575 COSY_RS02880 600407 600733 + sulfur relay protein DsrC gene gene576 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02880 COSY_RS02885 COSY_0576 COSY_RS02885 601436 602743 - 3-phosphoshikimate 1-carboxyvinyltransferase catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis gene gene577 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02885 COSY_RS02890 COSY_0577 COSY_RS02890 602748 603602 - prephenate dehydrogenase gene gene578 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02890 COSY_RS02895 COSY_0578 COSY_RS02895 603599 603889 - hypothetical protein gene gene579 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02895 COSY_RS02900 COSY_0579 COSY_RS02900 603992 605092 - prephenate dehydratase gene gene580 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02900 COSY_RS02905 COSY_0580 COSY_RS02905 605103 606260 - 3-phosphoglycerate dehydrogenase gene gene581 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02905 COSY_RS02910 COSY_0581 COSY_RS02910 606260 607339 - phosphoserine aminotransferase gene gene582 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02910 COSY_RS02915 COSY_RS02915 COSY_RS02915 607703 607897 + hypothetical protein gene gene583 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02915 COSY_RS02920 COSY_0582 COSY_RS02920 609059 609628 + hypothetical protein gene gene584 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02920 COSY_RS02925 COSY_0583 COSY_RS02925 609635 610228 + cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase gene gene585 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02925 COSY_RS02930 COSY_0584 glyA glyA 610250 611509 - serine hydroxymethyltransferase catalyzes the reaction of glycine with 5%2C10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate gene gene586 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02930 COSY_RS02935 COSY_t22 COSY_RS02935 612096 612169 - tRNA-Pro tRNA gene587 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02935 COSY_RS02940 COSY_RS02940 COSY_RS02940 612644 612859 + hypothetical protein gene gene588 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02940 COSY_RS02945 COSY_0587 COSY_RS02945 612903 613394 - peptide methionine sulfoxide reductase MsrA gene gene589 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02945 COSY_RS02950 COSY_0588 COSY_RS02950 613810 614277 + hypothetical protein gene gene590 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02950 COSY_RS02955 COSY_RS02955 COSY_RS02955 614346 614675 - integration host factor subunit alpha gene gene591 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02955 COSY_RS02960 COSY_0590 COSY_RS02960 614675 617041 - phenylalanine--tRNA ligase subunit beta gene gene592 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02960 COSY_RS02965 COSY_0591 COSY_RS02965 617038 618051 - phenylalanyl-tRNA synthetase subunit alpha gene gene593 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02965 COSY_RS02970 COSY_0592 rplT rplT 618423 618782 - 50S ribosomal protein L20 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit gene gene594 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02970 COSY_RS02975 COSY_0593 COSY_RS02975 618795 618992 - 50S ribosomal protein L35 gene gene595 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02975 COSY_RS02980 COSY_0594 COSY_RS02980 619047 619577 - translation initiation factor IF-3 gene gene596 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02980 COSY_RS02985 COSY_0595 COSY_RS02985 619556 621466 - threonine--tRNA ligase gene gene597 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02985 COSY_RS02990 COSY_0596 COSY_RS02990 621521 623239 - ssDNA exonuclease RecJ 5'-3' single-stranded-DNA-specific exonuclease gene gene598 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02990 COSY_RS02995 COSY_0597 COSY_RS02995 623229 623780 - hypothetical protein gene gene599 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS02995 COSY_RS03000 COSY_0598 COSY_RS03000 623773 624759 - FAD-dependent oxidoreductase gene gene600 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03000 COSY_RS03005 COSY_0599 COSY_RS03005 624756 625214 - signal peptidase II gene gene601 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03005 COSY_RS03010 COSY_0600 COSY_RS03010 625575 626357 + enoyl-ACP reductase Catalyzes a key regulatory step in fatty acid biosynthesis gene gene602 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03010 COSY_RS03015 COSY_0601 COSY_RS03015 626742 628589 - peptidyl-prolyl cis-trans isomerase gene gene603 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03015 COSY_RS03020 COSY_t23 COSY_RS03020 628751 628827 - tRNA-Asp tRNA gene604 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03020 COSY_RS03025 COSY_t24 COSY_RS03025 628839 628914 - tRNA-Val tRNA gene605 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03025 COSY_RS03030 COSY_0604 COSY_RS03030 628963 629238 - transcriptional regulator histone-like DNA-binding protein gene gene606 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03030 COSY_RS03035 COSY_0605 COSY_RS03035 629366 629896 - thiol:disulfide interchange protein DsbE gene gene607 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03035 COSY_RS03040 COSY_0606 COSY_RS03040 629893 630315 - cytochrome c-type biogenesis protein CcmE gene gene608 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03040 COSY_RS03045 COSY_0607 COSY_RS03045 630487 631227 - heme ABC transporter permease gene gene609 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03045 COSY_RS03050 COSY_0608 COSY_RS03050 631266 631922 - tRNA threonylcarbamoyladenosine biosynthesis protein TsaB gene gene610 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03050 COSY_RS03055 COSY_0609 COSY_RS03055 632487 632828 + 30S ribosomal protein S6 gene gene611 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03055 COSY_RS03060 COSY_0610 rpsR rpsR 632828 633082 + 30S ribosomal protein S18 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA%3B helps stabilize the platform of the 30S subunit gene gene612 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03060 COSY_RS03065 COSY_0611 rplI rplI 633092 633544 + 50S ribosomal protein L9 in Escherichia coli this protein is wrapped around the base of the L1 stalk gene gene613 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03065 COSY_RS03070 COSY_0612 COSY_RS03070 633630 635075 + DNA helicase gene gene614 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03070 COSY_RS03075 COSY_0613 COSY_RS03075 635090 636139 + alanine racemase gene gene615 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03075 COSY_RS03080 COSY_0614 COSY_RS03080 636136 636837 + 3'%2C5'-cyclic adenosine monophosphate phosphodiesterase CpdA gene gene616 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03080 COSY_RS03085 COSY_0615 COSY_RS03085 637054 637977 + 5'-nucleotidase gene gene617 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03085 COSY_RS03090 COSY_0616 COSY_RS03090 638115 639053 + hypothetical protein gene gene618 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03090 COSY_RS03095 COSY_0617 COSY_RS03095 639500 639859 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase gene gene619 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03095 COSY_RS03100 COSY_0618 COSY_RS03100 640605 641873 + histidine--tRNA ligase gene gene620 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03100 COSY_RS03105 COSY_0619 COSY_RS03105 641870 642487 + hypothetical protein gene gene621 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03105 COSY_RS03110 COSY_0620 COSY_RS03110 642494 643891 + ribosome-associated GTPase EngA gene gene622 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03110 COSY_RS03115 COSY_0621 pyrG pyrG 644613 646235 - CTP synthase CTP synthase%3B cytidine triphosphate synthetase%3B catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen%3B in Escherichia coli this enzyme forms a homotetramer gene gene623 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03115 COSY_RS03120 COSY_0622 COSY_RS03120 646331 648052 + ABC transporter gene gene624 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03120 COSY_RS03125 COSY_0623 COSY_RS03125 648228 648803 - hypothetical protein gene gene625 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03125 COSY_RS03130 COSY_0624 COSY_RS03130 648784 649683 - cyanophycin synthetase gene gene626 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03130 COSY_RS03135 COSY_0625 COSY_RS03135 649680 650489 - hypothetical protein gene gene627 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03135 COSY_RS03140 COSY_0626 COSY_RS03140 650479 650967 - hypothetical protein gene gene628 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03140 COSY_RS03145 COSY_0627 COSY_RS03145 650960 652348 - hypothetical protein gene gene629 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03145 COSY_RS03150 COSY_0628 COSY_RS03150 652350 652811 - hypothetical protein gene gene630 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03150 COSY_RS03155 COSY_0629 COSY_RS03155 652856 653920 - anthranilate phosphoribosyltransferase gene gene631 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03155 COSY_RS03160 COSY_0630 COSY_RS03160 653917 654213 - (2Fe-2S)-binding protein gene gene632 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03160 COSY_RS03165 COSY_0631 COSY_RS03165 654219 654824 - lipoprotein gene gene633 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03165 COSY_RS03170 COSY_0632 COSY_RS03170 654821 655138 - cold-shock protein gene gene634 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03170 COSY_RS03175 COSY_0633 COSY_RS03175 655781 656272 + thioredoxin gene gene635 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03175 COSY_RS03180 COSY_0634 COSY_RS03180 656269 656928 + uracil-DNA glycosylase gene gene636 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03180 COSY_RS03185 COSY_0635 COSY_RS03185 656928 657965 + erythronate-4-phosphate dehydrogenase gene gene637 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03185 COSY_RS03190 COSY_0636 COSY_RS03190 658536 660236 - serine/threonine protein kinase gene gene638 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03190 COSY_RS03195 COSY_0637 COSY_RS03195 660239 661705 - MFS transporter gene gene639 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03195 COSY_RS03200 COSY_0638 COSY_RS03200 661708 664077 - nitrite reductase gene gene640 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03200 COSY_RS03205 COSY_0639 COSY_RS03205 664377 664826 + molybdopterin guanine dinucleotide biosynthesis protein MoaE gene gene641 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03205 COSY_RS03210 COSY_0640 COSY_RS03210 664829 665413 - molybdenum cofactor guanylyltransferase gene gene642 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03210 COSY_RS03215 COSY_0641 COSY_RS03215 665492 666763 + molybdopterin molybdochelatase gene gene643 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03215 COSY_RS03220 COSY_0642 COSY_RS03220 666760 667266 + molybdenum cofactor biosynthesis protein C gene gene644 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03220 COSY_RS03225 COSY_0643 COSY_RS03225 667259 668254 + cyclic pyranopterin phosphate synthase MoaA gene gene645 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03225 COSY_RS03230 COSY_0644 COSY_RS03230 668273 668509 + molybdopterin synthase gene gene646 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03230 COSY_RS03235 COSY_0645 COSY_RS03235 669306 669758 - hypothetical protein gene gene647 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03235 COSY_RS03240 COSY_0646 COSY_RS03240 669765 670445 - nitrate reductase A subunit gamma gene gene648 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03240 COSY_RS03245 COSY_0647 COSY_RS03245 670461 671117 - respiratory nitrate reductase delta subunit gene gene649 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03245 COSY_RS03250 COSY_0648 narH narH 671114 672655 - nitrate reductase A subunit beta with NarGJI catalyzes the reduction of nitrate%3B the beta subunit is an iron sulfur cluster containing electron transfer subunit%3B one of 3 nitrate reductases in E. coli and in E. coli is expressed when nitrate levels are high gene gene650 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03250 COSY_RS03255 COSY_0649 narZ narZ 672655 676386 - nitrate reductase A subunit alpha with NarYV catalyzes the reduction of nitrate%3B the beta subunit is an iron sulfur cluster containing electron transfer subunit%3B one of 3 nitrate reductases in E. coli%3B expression of nitrate reductase Z is not dependent on nitrate levels gene gene651 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03255 COSY_RS03260 COSY_0650 COSY_RS03260 677171 677701 + molybdopterin adenylyltransferase gene gene652 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03260 COSY_RS03265 COSY_RS03265 COSY_RS03265 677706 678095 - hypothetical protein gene gene653 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03265 COSY_RS03270 COSY_0651 COSY_RS03270 678095 680341 - VWA domain-containing protein gene gene654 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03270 COSY_RS03275 COSY_0652 COSY_RS03275 680357 681166 - ATPase AAA gene gene655 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03275 COSY_RS03280 COSY_0653 COSY_RS03280 681254 682636 - ribulose bisphosphate carboxylase catalyzes the carboxylation of D-ribulose 1%2C5-bisphosphate in carbon dioxide fixation gene gene656 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03280 COSY_RS03290 COSY_0655 argJ argJ 683624 684841 - N-acetylglutamate synthase bifunctional arginine biosynthesis protein ArgJ%3B functions at the 1st and 5th steps in arginine biosynthesis%3B involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate gene gene658 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03290 COSY_RS03295 COSY_0656 COSY_RS03295 684950 686545 - ABC transporter permease gene gene659 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03295 COSY_RS03300 COSY_0657 COSY_RS03300 686627 687646 - iron deficiency-induced protein A gene gene660 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03300 COSY_RS03305 COSY_0658 COSY_RS03305 687702 688352 - ABC transporter gene gene661 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03305 COSY_RS03310 COSY_0659 COSY_RS03310 688419 690113 - cell division protein gene gene662 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03310 COSY_RS03315 COSY_0660 COSY_RS03315 690174 691070 - sterol desaturase gene gene663 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03315 COSY_RS03320 COSY_0661 COSY_RS03320 691066 692028 - hypothetical protein gene gene664 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03320 COSY_RS03325 COSY_0662 COSY_RS03325 692038 693405 - hypothetical protein gene gene665 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03325 COSY_RS03330 COSY_0663 COSY_RS03330 693383 694693 - imelysin gene gene666 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03330 COSY_RS03335 COSY_0664 COSY_RS03335 695502 696641 + cation transporter gene gene667 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03335 COSY_RS03340 COSY_0665 COSY_RS03340 696989 697348 + thioredoxin gene gene668 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03340 COSY_RS03345 COSY_0666 COSY_RS03345 697355 697681 - arsenate reductase gene gene669 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03345 COSY_RS03350 COSY_0667 COSY_RS03350 697678 698310 - hypothetical protein gene gene670 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03350 COSY_RS03355 COSY_0668 COSY_RS03355 698314 698727 - hypothetical protein gene gene671 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03355 COSY_RS03360 COSY_0669 COSY_RS03360 699148 701181 - glycine--tRNA ligase subunit beta gene gene672 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03360 COSY_RS03365 COSY_0670 COSY_RS03365 701896 702288 - hypothetical protein gene gene673 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03365 COSY_RS03370 COSY_0671 COSY_RS03370 702288 703127 - hypothetical protein gene gene674 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03370 COSY_RS03375 COSY_0672 COSY_RS03375 703127 703579 - biopolymer transporter protein ExbD gene gene675 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03375 COSY_RS03380 COSY_0673 COSY_RS03380 703572 704264 - flagellar motor protein MotA membrane spanning protein in TolA-TolQ-TolR complex%3B involved in the tonB-independent uptake of group A colicins gene gene676 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03380 COSY_RS03385 COSY_0674 ruvB ruvB 704657 705685 - Holliday junction DNA helicase RuvB promotes strand exchange during homologous recombination%3B RuvAB complex promotes branch migration%3B RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences%3B forms hexameric rings around opposite DNA arms%3B requires ATP for branch migration and orientation of RuvAB complex determines direction of migration gene gene677 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03385 COSY_RS03390 COSY_0675 hemA hemA 706287 707537 + glutamyl-tRNA reductase catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH%3B the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid%3B functions in porphyrin (tetrapyrroles) biosynthesis%3B the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins gene gene678 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03390 COSY_RS03395 COSY_0676 prfA prfA 707537 708622 + peptide chain release factor 1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1%3B this protein is similar to release factor 2 gene gene679 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03395 COSY_RS03400 COSY_0677 COSY_RS03400 709041 709829 - membrane protein gene gene680 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03400 COSY_RS03405 COSY_0678 COSY_RS03405 709835 710242 - Fur family transcriptional regulator gene gene681 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03405 COSY_RS03410 COSY_0679 COSY_RS03410 710308 710805 + hypothetical protein gene gene682 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03410 COSY_RS03415 COSY_0680 COSY_RS03415 710873 711832 - peptidase S49 gene gene683 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03415 COSY_RS03420 COSY_0681 COSY_RS03420 711848 712444 + heme exporter ATP-binding protein CcmA gene gene684 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03420 COSY_RS03425 COSY_0682 COSY_RS03425 712441 713106 + cytochrome C biogenesis protein gene gene685 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03425 COSY_RS03430 COSY_0683 COSY_RS03430 713260 714393 + S-adenosylmethionine synthetase catalyzes the formation of S-adenosylmethionine from methionine and ATP%3B methionine adenosyltransferase gene gene686 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03430 COSY_RS03435 COSY_0684 COSY_RS03435 714463 715788 + adenosylhomocysteinase gene gene687 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03435 COSY_RS03440 COSY_0685 COSY_RS03440 715880 716803 + glycyl-tRNA synthetase subunit alpha gene gene688 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03440 COSY_RS03445 COSY_0686 COSY_RS03445 716805 717377 + hypothetical protein gene gene689 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03445 COSY_RS03450 COSY_0687 COSY_RS03450 717358 717843 + hypothetical protein gene gene690 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03450 COSY_RS03455 COSY_0688 COSY_RS03455 718000 719325 + tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase gene gene691 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03455 COSY_RS03460 COSY_0689 COSY_RS03460 719726 720406 - electron transporter SenC gene gene692 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03460 COSY_RS03465 COSY_0690 COSY_RS03465 720750 721253 - hypothetical protein gene gene693 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03465 COSY_RS03470 COSY_0691 mnmA mnmA 722294 723382 + tRNA-specific 2-thiouridylase MnmA catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs gene gene694 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03470 COSY_RS03475 COSY_0692 COSY_RS03475 723385 723996 + High frequency lysogenization protein HflD homolog gene gene695 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03475 COSY_RS03480 COSY_0693 COSY_RS03480 724084 724344 + 30S ribosomal protein S20 gene gene696 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03480 COSY_RS03485 COSY_0694 COSY_RS03485 724501 724983 + hypothetical protein gene gene697 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03485 COSY_RS03490 COSY_0695 COSY_RS03490 724988 726388 + exodeoxyribonuclease 7 large subunit gene gene698 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03490 COSY_RS03495 COSY_0696 COSY_RS03495 727340 727579 + hypothetical protein gene gene699 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03495 COSY_RS03500 COSY_0697 COSY_RS03500 727955 728683 + 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase gene gene700 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03500 COSY_RS03505 COSY_0698 COSY_RS03505 728680 729150 + 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase gene gene701 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03505 COSY_RS03510 COSY_0699 murC murC 729150 730559 + UDP-N-acetylmuramate--L-alanine ligase Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis gene gene702 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03510 COSY_RS03515 COSY_0700 COSY_RS03515 730592 731404 + UDP-N-acetylmuramate dehydrogenase gene gene703 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03515 COSY_RS03520 COSY_0701 COSY_RS03520 731401 732282 + D-alanine--D-alanine ligase gene gene704 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03520 COSY_RS03525 COSY_0702 COSY_RS03525 733472 733780 - transcriptional regulator gene gene705 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03525 COSY_RS03530 COSY_0703 COSY_RS03530 734693 735610 + tRNA dimethylallyltransferase gene gene706 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03530 COSY_RS03535 COSY_0704 COSY_RS03535 735779 737077 - UDP-N-acetylmuramoylalanine--D-glutamate ligase gene gene707 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03535 COSY_RS03540 COSY_0705 COSY_RS03540 737138 737797 + hypothetical protein gene gene708 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03540 COSY_RS03545 COSY_0706 COSY_RS03545 738300 739586 + homoserine dehydrogenase catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine gene gene709 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03545 COSY_RS03550 COSY_0707 COSY_RS03550 739597 740661 + threonine synthase gene gene710 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03550 COSY_RS03555 COSY_0708 COSY_RS03555 740680 741567 + cysteine synthase gene gene711 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03555 COSY_RS03560 COSY_0709 COSY_RS03560 741564 742847 + chloride channel protein gene gene712 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03560 COSY_RS03565 COSY_0710 COSY_RS03565 742834 743256 - membrane protein gene gene713 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03565 COSY_RS03570 COSY_0711 COSY_RS03570 743870 744829 + signal recognition particle-docking protein FtsY gene gene714 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03570 COSY_RS03575 COSY_0712 COSY_RS03575 745572 746486 - porphobilinogen deaminase gene gene715 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03575 COSY_RS03580 COSY_0713 COSY_RS03580 746485 746883 + hypothetical protein gene gene716 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03580 COSY_RS03585 COSY_0714 COSY_RS03585 747022 748404 + argininosuccinate lyase gene gene717 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03585 COSY_RS03590 COSY_0715 COSY_RS03590 748404 749372 + methionyl-tRNA formyltransferase gene gene718 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03590 COSY_RS03595 COSY_0716 COSY_RS03595 749621 752179 + chaperone protein ClpB gene gene719 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03595 COSY_RS03600 COSY_0717 COSY_RS03600 752249 752890 + electron transporter RsxE in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents%3B similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase gene gene720 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03600 COSY_RS03605 COSY_0718 COSY_RS03605 753135 753947 + modification methylase HemK gene gene721 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03605 COSY_RS03610 COSY_0719 COSY_RS03610 754588 756078 - fumarate hydratase catalyzes the formation of fumarate from malate gene gene723 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03610 COSY_RS03615 COSY_0720 COSY_RS03615 756239 757237 + rod shape-determining protein MreB gene gene724 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03615 COSY_RS03620 COSY_0721 COSY_RS03620 757274 758068 + rod shape-determining protein MreC gene gene725 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03620 COSY_RS03625 COSY_0722 COSY_RS03625 758071 758541 + rod shape-determining protein MreD gene gene726 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03625 COSY_RS03630 COSY_0723 COSY_RS03630 758529 760379 + peptidoglycan glycosyltransferase gene gene727 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03630 COSY_RS03635 COSY_0724 tgt tgt 760686 761798 - queuine tRNA-ribosyltransferase Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp%2C -Asn%2C -His and -Tyr) gene gene728 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03635 COSY_RS03640 COSY_0725 COSY_RS03640 761788 763581 - metal ABC transporter permease gene gene729 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03640 COSY_RS03645 COSY_0726 COSY_RS03645 764042 765091 + diaminohydroxyphosphoribosylaminopyrimidine deaminase gene gene730 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03645 COSY_RS03650 COSY_0727 COSY_RS03650 765088 766281 + phosphopantothenoylcysteine decarboxylase gene gene731 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03650 COSY_RS03655 COSY_0728 COSY_RS03655 766893 770318 - DNA polymerase III subunit alpha gene gene732 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03655 COSY_RS03660 COSY_0729 COSY_RS03660 770460 770777 - hypothetical protein gene gene733 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03660 COSY_RS03665 COSY_0730 COSY_RS03665 770792 771607 - sulfur oxidation c-type cytochrome SoxA gene gene734 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03665 COSY_RS03670 COSY_0731 COSY_RS03670 771635 771937 - thiosulfate oxidation carrier complex protein SoxZ gene gene735 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03670 COSY_RS03675 COSY_0732 COSY_RS03675 771971 772414 - sulfur oxidation protein SoxY gene gene736 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03675 COSY_RS03680 COSY_0733 COSY_RS03680 772425 772772 - sulfur oxidation c-type cytochrome SoxX gene gene737 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03680 COSY_RS03685 COSY_0734 COSY_RS03685 772996 774450 - anthranilate synthase subunit I with component II%2C the glutamine amidotransferase%2C catalyzes the formation of anthranilate from chorismate and glutamine gene gene738 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03685 COSY_RS03690 COSY_0735 COSY_RS03690 774538 778719 - DNA-directed RNA polymerase subunit beta' DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter gene gene739 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03690 COSY_RS03695 COSY_0736 rpoB rpoB 778733 782815 - DNA-directed RNA polymerase subunit beta DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme gene gene740 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03695 COSY_RS03700 COSY_0737 rplL rplL 782985 783359 - 50S ribosomal protein L7/L12 present in two forms%3B L12 is normal%2C while L7 is aminoacylated at the N-terminal serine%3B the only multicopy ribosomal protein%3B 4:1 ratio of L7/L12 per ribosome%3B two L12 dimers bind L10%3B critically important for translation efficiency and fidelity%3B stimulates GTPase activity of translation factors gene gene741 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03700 COSY_RS03705 COSY_0738 COSY_RS03705 783382 783906 - 50S ribosomal protein L10 gene gene742 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03705 COSY_RS03710 COSY_0739 COSY_RS03710 784107 784805 - 50S ribosomal protein L1 gene gene743 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03710 COSY_RS03715 COSY_0740 COSY_RS03715 784807 785235 - 50S ribosomal protein L11 gene gene744 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03715 COSY_RS03720 COSY_0741 COSY_RS03720 785326 785859 - transcription termination/antitermination factor NusG gene gene745 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03720 COSY_RS03725 COSY_0742 COSY_RS03725 785870 786196 - preprotein translocase subunit SecE gene gene746 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03725 COSY_RS03730 COSY_t25 COSY_RS03730 786258 786333 - tRNA-Trp tRNA gene747 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03730 COSY_RS03735 COSY_0744 tuf tuf 786412 787602 - elongation factor Tu EF-Tu%3B promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B when the tRNA anticodon matches the mRNA codon%2C GTP hydrolysis results%3B the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts%3B many prokaryotes have two copies of the gene encoding EF-Tu gene gene748 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03735 COSY_RS03740 COSY_t26 COSY_RS03740 787637 787712 - tRNA-Thr tRNA gene749 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03740 COSY_RS03745 COSY_t27 COSY_RS03745 787728 787801 - tRNA-Gly tRNA gene750 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03745 COSY_RS03750 COSY_t28 COSY_RS03750 787821 787905 - tRNA-Tyr tRNA gene751 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03750 COSY_RS03755 COSY_0748 COSY_RS03755 788001 789221 - malate dehydrogenase gene gene752 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03755 COSY_RS03760 COSY_0749 COSY_RS03760 789721 790059 - hydrolase gene gene753 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03760 COSY_RS03765 COSY_0750 COSY_RS03765 790563 791690 - pyridine nucleotide-disulfide oxidoreductase gene gene754 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03765 COSY_RS03770 COSY_RS03770 COSY_RS03770 791683 791922 - hypothetical protein gene gene755 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03770 COSY_RS03775 COSY_0751 COSY_RS03775 791950 792531 + malonic semialdehyde reductase gene gene756 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03775 COSY_RS03780 COSY_0752 COSY_RS03780 792701 792949 - hypothetical protein gene gene757 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03780 COSY_RS03785 COSY_0753 COSY_RS03785 792965 793663 - Zn-dependent hydrolase gene gene758 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03785 COSY_RS03790 COSY_0754 COSY_RS03790 793944 794687 - 4-hydroxy-tetrahydrodipicolinate reductase gene gene759 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03790 COSY_RS03795 COSY_0755 COSY_RS03795 794837 795670 - 2-dehydro-3-deoxyphosphooctonate aldolase gene gene760 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03795 COSY_RS03800 COSY_0756 trpC trpC 795875 796681 + indole-3-glycerol-phosphate synthase involved in tryptophan biosynthesis%3B amino acid biosynthesis%3B converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water gene gene761 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03800 COSY_RS03805 COSY_0757 COSY_RS03805 796678 797091 + peroxiredoxin gene gene762 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03805 COSY_RS03810 COSY_t29 COSY_RS03810 797611 797703 + tRNA-Ser tRNA gene763 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03810 COSY_RS03815 COSY_0759 COSY_RS03815 797828 798607 + thiazole synthase gene gene764 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03815 COSY_RS03820 COSY_0760 COSY_RS03820 799156 800253 + 8-amino-7-oxononanoate synthase gene gene765 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03820 COSY_RS03825 COSY_0761 COSY_RS03825 800243 800980 + alpha/beta hydrolase gene gene766 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03825 COSY_RS03830 COSY_0762 COSY_RS03830 800995 801483 + N5-carboxyaminoimidazole ribonucleotide mutase gene gene767 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03830 COSY_RS03835 COSY_0763 COSY_RS03835 801487 802566 + phosphoribosylaminoimidazole carboxylase gene gene768 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03835 COSY_RS03840 COSY_0764 COSY_RS03840 802574 802948 - glutaredoxin gene gene769 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03840 COSY_RS03845 COSY_0765 COSY_RS03845 802945 803778 - bifunctional protein FolD catalyzes the formation of 5%2C10-methenyltetrahydrofolate from 5%2C10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5%2C10-methenyltetrahydrofolate gene gene770 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03845 COSY_RS03850 COSY_0766 COSY_RS03850 803782 804516 - 3-deoxy-manno-octulosonate cytidylyltransferase CMP-2-keto-3-deoxyoctulosonic acid synthetase%3B catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS gene gene771 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03850 COSY_RS03855 COSY_0767 COSY_RS03855 804516 804695 - hypothetical protein gene gene772 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03855 COSY_RS03860 COSY_0768 COSY_RS03860 804692 805639 - tetraacyldisaccharide 4'-kinase gene gene773 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03860 COSY_RS03865 COSY_0769 COSY_RS03865 806066 807301 + lipoprotein ABC transporter permease LolE gene gene774 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03865 COSY_RS03870 COSY_0770 COSY_RS03870 807294 807968 + ABC transporter ATP-binding protein gene gene775 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03870 COSY_RS03875 COSY_0771 COSY_RS03875 808390 808773 - aspartate 1-decarboxylase gene gene776 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03875 COSY_RS03880 COSY_0772 COSY_RS03880 808783 809913 - glutaconyl-CoA decarboxylase subunit beta gene gene777 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03880 COSY_RS03885 COSY_0773 COSY_RS03885 809928 811757 - oxaloacetate decarboxylase gene gene778 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03885 COSY_RS03890 COSY_RS03890 COSY_RS03890 811763 812002 - sodium pump decarboxylase subunit gamma gene gene779 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03890 COSY_RS03895 COSY_t30 COSY_RS03895 812023 812107 - tRNA-Leu tRNA gene780 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03895 COSY_RS03900 COSY_0775 infA infA 812116 812334 - translation initiation factor IF-1 stimulates the activities of the other two initiation factors%2C IF-2 and IF-3 gene gene781 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03900 COSY_RS03905 COSY_0776 COSY_RS03905 812501 813322 + 5%2C10-methylenetetrahydrofolate reductase gene gene782 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03905 COSY_RS03910 COSY_0777 COSY_RS03910 813334 813798 - hypothetical protein gene gene783 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03910 COSY_RS03915 COSY_0778 COSY_RS03915 813816 814562 - uroporphyrinogen III methyltransferase gene gene784 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03915 COSY_RS03920 COSY_0779 COSY_RS03920 814566 815159 - hypothetical protein gene gene785 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03920 COSY_RS03925 COSY_0780 COSY_RS03925 815229 816173 + calcium/sodium:proton antiporter YrbG%3B inner membrane protein involved in cell envelope integrity%3B putative sodium ion/calcium ion exchanger%3B in E. coli it is non essential for cell viability%3B member of the YRBG family of cation/Ca2+ exchangers gene gene786 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03925 COSY_RS03930 COSY_0781 COSY_RS03930 816170 816625 + tRNA threonylcarbamoyladenosine biosynthesis protein TsaE gene gene787 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03930 COSY_RS03935 COSY_0782 COSY_RS03935 817196 817537 - sulfur oxidoreductase gene gene788 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03935 COSY_RS03940 COSY_0783 COSY_RS03940 817534 818910 - cobyrinic acid a%2Cc-diamide synthase gene gene789 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03940 COSY_RS03945 COSY_0784 COSY_RS03945 818938 820140 - molybdopterin oxidoreductase gene gene790 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03945 COSY_RS03950 COSY_0785 COSY_RS03950 820166 820897 - 4Fe-4S ferredoxin gene gene791 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03950 COSY_RS03955 COSY_0786 COSY_RS03955 820894 821277 - intracellular sulfur oxidation protein DsrJ gene gene792 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03955 COSY_RS03960 COSY_0787 COSY_RS03960 821307 823271 - glutamate synthase gene gene793 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03960 COSY_RS03965 COSY_0788 COSY_RS03965 823327 824892 - reductase gene gene794 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03965 COSY_RS03970 COSY_0789 COSY_RS03970 824894 825667 - nitrate reductase gene gene795 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03970 COSY_RS03975 COSY_0790 COSY_RS03975 825744 826067 - sulfur transfer protein TusE transfers sulfur from TusBCD complex to MnmA%3B involved in thiouridation of U34 position of some tRNAs gene gene796 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03975 COSY_RS03980 COSY_0791 COSY_RS03980 826094 826390 - multidrug MFS transporter gene gene797 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03980 COSY_RS03985 COSY_0792 COSY_RS03985 826402 826806 - sulfur oxidoreductase gene gene798 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03985 COSY_RS03990 COSY_0793 COSY_RS03990 826810 827211 - sulfurtransferase gene gene799 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03990 COSY_RS03995 COSY_0794 COSY_RS03995 827224 828297 - sulfite reductase gene gene800 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS03995 COSY_RS04000 COSY_0795 COSY_RS04000 828373 829674 - sulfite reductase gene gene801 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04000 COSY_RS04005 COSY_0796 COSY_RS04005 829907 831340 - glutamate synthase subunit beta gene gene802 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04005 COSY_RS04010 COSY_0797 COSY_RS04010 831491 831844 + 50S ribosomal protein L19 gene gene803 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04010 COSY_RS04015 COSY_0798 greA greA 831932 832411 - transcription elongation factor GreA necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites%3B arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through%2C resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus gene gene804 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04015 COSY_RS04020 COSY_0799 carB carB 832414 835620 - carbamoyl phosphate synthase large subunit four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate%3B CarB is responsible for the amidotransferase activity gene gene805 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04020 COSY_RS04025 COSY_0800 COSY_RS04025 835643 836329 - ABC transporter gene gene806 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04025 COSY_RS04030 COSY_0801 COSY_RS04030 836326 837447 - carbamoyl phosphate synthase small subunit catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways%3B forms an octamer composed of four CarAB dimers gene gene807 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04030 COSY_RS04035 COSY_0802 COSY_RS04035 837558 837827 + heavy metal transporter gene gene808 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04035 COSY_RS04040 COSY_0803 COSY_RS04040 837824 838024 + thiamine biosynthesis protein ThiS gene gene809 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04040 COSY_RS04045 COSY_0804 COSY_RS04045 838542 839588 - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase gene gene810 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04045 COSY_RS04050 COSY_0805 COSY_RS04050 839956 840246 + sulfite reductase subunit gamma gene gene811 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04050 COSY_RS04055 COSY_0806 COSY_RS04055 840275 842872 - alanine--tRNA ligase gene gene812 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04055 COSY_RS04060 COSY_0807 COSY_RS04060 842921 843535 - translation factor Sua5 gene gene813 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04060 COSY_RS04065 COSY_0808 COSY_RS04065 843529 844359 - hypothetical protein gene gene814 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04065 COSY_RS04070 COSY_0809 COSY_RS04070 844437 846284 + glucosamine--fructose-6-phosphate aminotransferase Catalyzes the first step in hexosamine metabolism%2C converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source gene gene815 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04070 COSY_RS04075 COSY_0810 COSY_RS04075 846290 847528 + glucose-6-phosphate isomerase catalyzes the formation of D-fructose 6-phosphate from D-glucose 6-phosphate gene gene816 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04075 COSY_RS04080 COSY_0811 COSY_RS04080 847525 848358 + UTP--glucose-1-phosphate uridylyltransferase gene gene817 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04080 COSY_RS04085 COSY_0812 COSY_RS04085 849069 849797 + glycosyltransferase gene gene818 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04085 COSY_RS04090 COSY_RS04090 COSY_RS04090 849863 850162 + hypothetical protein gene gene819 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04090 COSY_RS04095 COSY_0813 COSY_RS04095 850417 851157 + hypothetical protein gene gene820 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04095 COSY_RS04100 COSY_RS04100 COSY_RS04100 851158 851934 + glycosyl transferase family protein gene gene821 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04100 COSY_RS04105 COSY_0815 COSY_RS04105 851947 852984 + glycosyl transferase gene gene822 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04105 COSY_RS04110 COSY_0816 COSY_RS04110 854027 855688 + glutamine--tRNA ligase catalyzes a two-step reaction%2C first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA gene gene823 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04110 COSY_RS04115 COSY_0817 surE surE 856135 856884 - 5'-nucleotidase surE broad specificity 5'(3')-nucleotidase and polyphosphatase gene gene824 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04115 COSY_RS04120 COSY_0818 clpA clpA 856907 859129 - ATP-dependent Clp protease ATP-binding subunit ClpA ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease%3B directs protease to specific substrates gene gene825 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04120 COSY_RS04125 COSY_0819 COSY_RS04125 859346 860428 - LPS export ABC transporter permease LptG gene gene826 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04125 COSY_RS04130 COSY_0820 guaA guaA 860476 862038 + GMP synthase contains glutamine-hydrolyzing domain and glutamine amidotransferase%3B GMP-binding domain%3B functions to produce GMP from XMP in the IMP pathway gene gene827 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04130 COSY_RS04135 COSY_0821 COSY_RS04135 862029 862490 + zinc-binding protein gene gene828 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04135 COSY_RS04140 COSY_0822 fabG fabG 862508 863254 - 3-ketoacyl-ACP reductase catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis gene gene829 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04140 COSY_RS04145 COSY_0823 COSY_RS04145 863251 864183 - malonyl CoA-ACP transacylase gene gene830 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04145 COSY_RS04150 COSY_0824 rpmA rpmA 864271 864528 - 50S ribosomal protein L27 involved in the peptidyltransferase reaction during translation gene gene831 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04150 COSY_RS04155 COSY_0825 rplU rplU 864540 864851 - 50S ribosomal protein L21 gene gene832 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04155 COSY_RS04160 COSY_0826 COSY_RS04160 864977 865462 + cyclophilin gene gene833 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04160 COSY_RS04165 COSY_0827 COSY_RS04165 865465 866187 + UDP-2%2C3-diacylglucosamine hydrolase gene gene834 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04165 COSY_RS04170 COSY_0828 COSY_RS04170 866152 867957 - ribonuclease II family protein gene gene835 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04170 COSY_RS04175 COSY_0829 COSY_RS04175 867966 868340 - glycine cleavage system protein H part of multienzyme complex composed of H%2C L%2C P%2C and T proteins which catalyzes oxidation of glycine to yield carbon dioxide%2C ammonia%2C 5%2C10-CH2-H4folate and a reduced pyridine nucleotide%3B protein H is involved in transfer of methylamine group from the P to T protein%3B covalently bound to a lipoyl cofactor gene gene836 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04175 COSY_RS04180 COSY_0830 gcvT gcvT 868384 869463 - glycine cleavage system protein T catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate%2C causing the release of ammonia and the generation of reduced GcvH protein gene gene837 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04180 COSY_RS04185 COSY_0831 COSY_RS04185 869460 870113 - septation protein A gene gene838 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04185 COSY_RS04190 COSY_0832 COSY_RS04190 870114 870323 - hypothetical protein gene gene839 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04190 COSY_RS04195 COSY_t31 COSY_RS04195 870408 870495 + tRNA-Leu tRNA gene840 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04195 COSY_RS04200 COSY_0834 COSY_RS04200 870701 871108 + reactive intermediate/imine deaminase gene gene841 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04200 COSY_RS04205 COSY_0835 COSY_RS04205 871179 873245 + DEAD/DEAH box helicase catalyzes branch migration in Holliday junction intermediates gene gene842 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04205 COSY_RS04210 COSY_0836 COSY_RS04210 873277 873741 + chorismate lyase gene gene843 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04210 COSY_RS04215 COSY_0837 COSY_RS04215 874189 874776 + anthranilate synthase subunit II TrpG%3B with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine%3B TrpG provides the glutamine amidotransferase activity gene gene844 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04215 COSY_RS04220 COSY_0838 COSY_RS04220 874780 875199 + sulfurtransferase gene gene845 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04220 COSY_RS04225 COSY_0839 COSY_RS04225 875203 875460 + glutaredoxin gene gene846 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04225 COSY_RS04230 COSY_0840 COSY_RS04230 875457 876440 + glycerol-3-phosphate dehydrogenase [NAD(P)+] gene gene847 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04230 COSY_RS04235 COSY_0841 COSY_RS04235 876437 876964 + alpha-ribazole phosphatase gene gene848 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04235 COSY_RS04240 COSY_0842 COSY_RS04240 877363 877758 - 30S ribosomal protein S9 gene gene849 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04240 COSY_RS04245 COSY_0843 COSY_RS04245 877771 878199 - 50S ribosomal protein L13 gene gene850 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04245 COSY_RS04250 COSY_0844 COSY_RS04250 878434 880260 + cold-shock protein gene gene851 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04250 COSY_RS04255 COSY_0845 COSY_RS04255 880954 881157 + cold-shock protein gene gene852 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04255 COSY_RS04260 COSY_0846 COSY_RS04260 881948 883369 + exodeoxyribonuclease I gene gene853 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04260 COSY_RS04265 COSY_0847 COSY_RS04265 883439 884071 + endonuclease IV gene gene854 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04265 COSY_RS04270 COSY_0848 hisH hisH 884510 885127 - imidazole glycerol phosphate synthase subunit HisH with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate%2C 5-aminoimidazol-4-carboxamide ribonucleotide%2C and glutamate in histidine biosynthesis%3B the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide gene gene855 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04270 COSY_RS04275 COSY_0849 COSY_RS04275 885134 885712 - imidazoleglycerol-phosphate dehydratase gene gene856 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04275 COSY_RS04280 COSY_0851 COSY_RS04280 885942 886964 - semialdehyde dehydrogenase gene gene857 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04280 COSY_RS04285 COSY_0852 COSY_RS04285 887570 888310 - Nif3-like dinuclear metal center hexameric protein gene gene858 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04285 COSY_RS04290 COSY_0853 COSY_RS04290 888320 889384 - histidinol-phosphate aminotransferase gene gene859 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04290 COSY_RS04295 COSY_0854 COSY_RS04295 889381 890133 - phosphomethylpyrimidine kinase gene gene860 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04295 COSY_RS04300 COSY_0855 COSY_RS04300 890126 890743 - DSBA oxidoreductase gene gene861 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04300 COSY_RS04305 COSY_0856 COSY_RS04305 890746 891228 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase gene gene862 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04305 COSY_RS04310 COSY_0857 COSY_RS04310 891221 891574 - dihydroneopterin triphosphate 2'-epimerase gene gene863 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04310 COSY_RS04315 COSY_0858 COSY_RS04315 891630 892220 + glycerol-3-phosphate acyltransferase gene gene864 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04315 COSY_RS04320 COSY_0859 COSY_RS04320 892320 893231 + polyphosphate kinase gene gene865 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04320 COSY_RS04325 COSY_0860 COSY_RS04325 893228 893482 + hypothetical protein gene gene866 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04325 COSY_RS04330 COSY_0861 COSY_RS04330 893582 894343 - ABC transporter permease gene gene867 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04330 COSY_RS04335 COSY_0862 COSY_RS04335 894340 895257 - multidrug ABC transporter ATP-binding protein gene gene868 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04335 COSY_RS04340 COSY_0863 COSY_RS04340 895662 896888 + branched-chain alpha-keto acid dehydrogenase subunit E2 gene gene869 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04340 COSY_RS04345 COSY_0864 COSY_RS04345 896881 898287 + dihydrolipoamide dehydrogenase E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex%3B catalyzes the oxidation of dihydrolipoamide to lipoamide gene gene870 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04345 COSY_RS04350 COSY_0865 COSY_RS04350 898299 898952 + protein-L-isoaspartate O-methyltransferase gene gene871 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04350 COSY_RS04355 COSY_0866 COSY_RS04355 898952 901336 + membrane protein gene gene872 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04355 COSY_RS04360 COSY_0867 COSY_RS04360 901396 902967 + L-aspartate oxidase catalyzes the formation of oxaloacetate from L-aspartate gene gene873 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04360 COSY_RS04365 COSY_0868 COSY_RS04365 902964 903506 + peptide deformylase gene gene874 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04365 COSY_RS04370 COSY_RS04370 COSY_RS04370 903914 904153 + hypothetical protein gene gene875 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04370 COSY_RS04375 COSY_0869 purH purH 904190 905731 + purine biosynthesis protein purH involved in de novo purine biosynthesis gene gene876 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04375 COSY_RS04380 COSY_0870 COSY_RS04380 906146 907534 - DEAD/DEAH box helicase gene gene877 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04380 COSY_RS04385 COSY_0871 COSY_RS04385 907791 908348 + 5-formyltetrahydrofolate cyclo-ligase gene gene878 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04385 COSY_RS04390 COSY_0872 COSY_RS04390 908710 909891 - 2-octaprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol hydroxylase gene gene879 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04390 COSY_RS04395 COSY_0873 COSY_RS04395 909891 911210 - peptidase U62 gene gene880 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04395 COSY_RS04400 COSY_0874 COSY_RS04400 911264 911962 - hypothetical protein gene gene881 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04400 COSY_RS04405 COSY_0875 COSY_RS04405 911962 912810 - cobalt transporter gene gene882 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04405 COSY_RS04410 COSY_0876 COSY_RS04410 912849 913145 - hypothetical protein gene gene883 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04410 COSY_RS04415 COSY_0877 COSY_RS04415 913135 913866 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l-(5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide gene gene884 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04415 COSY_RS04420 COSY_RS04420 COSY_RS04420 914870 915085 - hypothetical protein gene gene885 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04420 COSY_RS04425 COSY_0878 COSY_RS04425 915176 916201 - tRNA N6-adenosine threonylcarbamoyltransferase universal genome maintenance protein%3B Kae1/Qri7/OSGEP/YgjD family protein%3B in Archaea%2C some Kae1 are found as fusion proteins similar to two distinct proteins in yeast that are involved in the KEOPS complex%3B kinase associated endopeptidase 1 (Kae1) and a serine/threonine protein kinase (Bud32)%3B in Pyrococcus Kae1 has atypical AP endonuclease activity and inhibits the kinase activity of Bud32%3B the protein is essential in Escherichia coli and Bacillus subtilis gene gene886 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04425 COSY_RS04430 COSY_0879 COSY_RS04430 916239 916961 - LPS export ABC transporter ATP-binding protein gene gene887 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04430 COSY_RS04435 COSY_0880 COSY_RS04435 917232 917990 - biotin--[acetyl-CoA-carboxylase] synthetase gene gene888 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04435 COSY_RS04440 COSY_0881 COSY_RS04440 918269 919012 + tRNA pseudouridine synthase A gene gene889 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04440 COSY_RS04445 COSY_0882 COSY_RS04445 919277 921220 + citrate transporter gene gene890 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04445 COSY_RS04450 COSY_0883 COSY_RS04450 921286 921876 + carbonic anhydrase gene gene891 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04450 COSY_RS04455 COSY_0884 COSY_RS04455 921911 922435 - ribosome maturation factor RimM gene gene892 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04455 COSY_RS04460 COSY_0885 rpsP rpsP 922472 922762 - 30S ribosomal protein S16 binds to lower part of 30S body where it stabilizes two domains%3B required for efficient assembly of 30S%3B in Escherichia coli this protein has nuclease activity gene gene893 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04460 COSY_RS04465 COSY_0886 COSY_RS04465 922827 924203 - adenylosuccinate lyase Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide gene gene894 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04465 COSY_RS04470 COSY_0887 COSY_RS04470 924327 926903 + bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase gene gene895 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04470 COSY_RS04475 COSY_0888 rpmG rpmG 926960 927115 - 50S ribosomal protein L33 in Escherichia coli BM108%2C a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function%3B there are paralogous genes in several bacterial genomes%2C and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31%3B the proteins in this group lack the CXXC motif gene gene896 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04475 COSY_RS04480 COSY_0889 rpmB rpmB 927112 927360 - 50S ribosomal protein L28 required for 70S ribosome assembly gene gene897 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04480 COSY_RS04485 COSY_t32 COSY_RS04485 927485 927574 + tRNA-Ser tRNA gene898 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04485 COSY_RS04490 COSY_0891 pyrE pyrE 928047 928689 - orotate phosphoribosyltransferase involved in fifth step of pyrimidine biosynthesis%3B converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate gene gene899 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04490 COSY_RS04495 COSY_0892 COSY_RS04495 928718 929485 + DNA-(apurinic or apyrimidinic site) lyase gene gene900 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04495 COSY_RS04500 COSY_0893 COSY_RS04500 930231 930911 + tRNA (guanine-N7)-methyltransferase gene gene901 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04500 COSY_RS04505 COSY_0894 COSY_RS04505 930913 931365 + exlusion protein FxsA gene gene902 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04505 COSY_RS04510 COSY_0895 COSY_RS04510 931353 932567 + bifunctional folylpolyglutamate synthase/dihydrofolate synthase gene gene903 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04510 COSY_RS04515 COSY_0896 COSY_RS04515 932616 933464 + hypothetical protein gene gene904 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04515 COSY_RS04520 COSY_0897 COSY_RS04520 933475 934992 + amidophosphoribosyltransferase gene gene905 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04520 COSY_RS04525 COSY_0898 COSY_RS04525 935018 936184 + O-succinylhomoserine sulfhydrylase catalyzes the conversion of O-succinylhomoserine into homocysteine gene gene906 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04525 COSY_RS04530 COSY_0899 COSY_RS04530 936213 936722 + 3-hydroxydecanoyl-ACP dehydratase catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2%2C3-decenoyl-ACP or 3%2C4-decenoyl-ACP gene gene907 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04530 COSY_RS04535 COSY_0900 COSY_RS04535 936722 937936 + 3-oxoacyl-ACP synthase FabB%2C beta-Ketoacyl-ACP synthase I%2C KASI%3B catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP%3B required for the elongation of short-chain unsaturated acyl-ACP gene gene908 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04535 COSY_RS04540 COSY_0901 COSY_RS04540 938378 939292 - preprotein translocase subunit SecF gene gene909 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04540 COSY_RS04545 COSY_0902 secD secD 939289 941136 - preprotein translocase subunit SecD part of the preprotein secretory system%3B when complexed with proteins SecF and YajC%2C SecDFyajC stimulates the proton motive force-driven protein translocation%2C and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane gene gene910 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04545 COSY_RS04550 COSY_0903 COSY_RS04550 941152 941493 - preprotein translocase subunit YajC gene gene911 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04550 COSY_RS04555 COSY_0904 COSY_RS04555 941515 942804 - serine--tRNA ligase gene gene912 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04555 COSY_RS04560 COSY_RS04560 COSY_RS04560 942804 943175 + sulfurtransferase gene gene913 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04560 COSY_RS04565 COSY_0906 COSY_RS04565 943209 943838 + hypothetical protein gene gene914 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04565 COSY_RS04570 COSY_0907 COSY_RS04570 943888 944310 + thioredoxin gene gene915 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04570 COSY_RS04575 COSY_0907a COSY_RS04575 944358 944473 - 5S ribosomal RNA rRNA gene916 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04575 COSY_RS04580 COSY_0907b COSY_RS04580 944654 947567 - 23S ribosomal RNA rRNA gene917 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04580 COSY_RS04585 COSY_t33 COSY_RS04585 948022 948097 - tRNA-Ala tRNA gene918 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04585 COSY_RS04590 COSY_t34 COSY_RS04590 948193 948269 - tRNA-Ile tRNA gene919 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04590 COSY_RS04595 COSY_0907d COSY_RS04595 948392 949943 - 16S ribosomal RNA rRNA gene920 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04595 COSY_RS04600 COSY_0913 COSY_RS04600 950273 950752 - sulfurtransferase gene gene921 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04600 COSY_RS04605 COSY_0914 COSY_RS04605 950758 951387 - LuxR family transcriptional regulator two-component response regulator NarL%3B phosphorylated by NarQ%3B activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase gene gene922 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04605 COSY_RS04610 COSY_0915 COSY_RS04610 951384 952868 - histidine kinase gene gene923 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04610 COSY_RS04615 COSY_0916 COSY_RS04615 952909 954252 - tRNA modification GTPase MnmE gene gene924 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04615 COSY_RS04620 COSY_0917 COSY_RS04620 954252 955814 - glutamate--cysteine ligase gene gene925 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04620 COSY_RS04630 COSY_0919 COSY_RS04630 957234 961754 + glutamate synthase gene gene927 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04630 COSY_RS04635 COSY_0920 COSY_RS04635 961807 962298 - dihydrofolate reductase gene gene928 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04635 COSY_RS04640 COSY_0921 COSY_RS04640 962357 962959 + septum formation inhibitor Maf Maf%3B overexpression in Bacillus subtilis inhibits septation in the dividing cell gene gene929 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04640 COSY_RS04645 COSY_0922 COSY_RS04645 962965 966399 + transcription-repair coupling factor gene gene930 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04645 COSY_RS04650 COSY_0923 COSY_RS04650 966414 967355 - sugar kinase gene gene931 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04650 COSY_RS04655 COSY_0924 ispH ispH 967424 968350 - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)%3B functions in the nonmevalonate isoprenoid biosynthesis pathway gene gene932 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04655 COSY_RS04660 COSY_0925 COSY_RS04660 968347 968754 - FKBP-type peptidyl-prolyl cis-trans isomerase gene gene933 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04660 COSY_RS04665 COSY_0926 COSY_RS04665 968747 969595 - acetyl-CoA carboxylase subunit beta catalyzes the carboxylation of acetyl-CoA to malonyl-CoA%3B forms a tetramer of AccA2D2 subunits gene gene934 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04665 COSY_RS04670 COSY_0927 COSY_RS04670 969615 970412 - tryptophan synthase alpha chain gene gene935 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04670 COSY_RS04675 COSY_0928 hemE hemE 970414 971451 - uroporphyrinogen decarboxylase catalyzes the formation of coproporphyrinogen from uroporphyrinogen III gene gene936 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04675 COSY_RS04680 COSY_0929 rpmE rpmE 971537 971749 - 50S ribosomal protein L31 RpmE%3B there appears to be two types of ribosomal proteins L31 in bacterial genomes%3B some contain a CxxC motif while others do not%3B Bacillus subtilis has both types%3B the proteins in this cluster have the CXXC motif%3B RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth%3B expression of ytiA is controlled by a zinc-specific transcriptional repressor%3B RpmE contains one zinc ion and a CxxC motif is responsible for this binding%3B forms an RNP particle along with proteins L5%2C L18%2C and L25 and 5S rRNA%3B found crosslinked to L2 and L25 and EF-G%3B may be near the peptidyltransferase site of the 50S ribosome gene gene937 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04680 COSY_RS04685 COSY_0930 COSY_RS04685 971831 974236 - ATPase P gene gene938 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04685 COSY_RS04690 COSY_0931 COSY_RS04690 974447 975118 + hypothetical protein gene gene939 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04690 COSY_RS04695 COSY_0932 glmU glmU 975128 976477 + bifunctional protein GlmU forms a homotrimer%3B catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc%3B function in cell wall synthesis gene gene940 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04695 COSY_RS04700 COSY_0933 COSY_RS04700 977043 978248 - tryptophan synthase subunit beta gene gene941 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04700 COSY_RS04705 COSY_0934 COSY_RS04705 978245 978853 - N-(5'-phosphoribosyl)anthranilate isomerase gene gene942 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04705 COSY_RS04710 COSY_0935 COSY_RS04710 978854 979561 - hypothetical protein gene gene943 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04710 COSY_RS04715 COSY_RS04715 COSY_RS04715 979573 979755 - sulfur relay protein DsrC gene gene944 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04715 COSY_RS04720 COSY_0936 COSY_RS04720 980324 982657 - DNA topoisomerase I gene gene945 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04720 COSY_RS04725 COSY_0937 COSY_RS04725 982657 983148 - Smg protein gene gene946 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04725 COSY_RS04730 COSY_0938 rpmH rpmH 984186 984326 + 50S ribosomal protein L34 in Escherichia coli transcription of this gene is enhanced by polyamines gene gene947 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04730 COSY_RS04735 COSY_0939 COSY_RS04735 984336 984677 + ribonuclease P protein component gene gene948 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04735 COSY_RS04740 COSY_0940 COSY_RS04740 984677 984892 + membrane protein insertion efficiency factor YidD gene gene949 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04740 COSY_RS04745 COSY_0941 COSY_RS04745 984912 986537 + protein translocase component YidC functions to insert inner membrane proteins into the IM in Escherichia coli%3B interacts with transmembrane segments%3B functions in both Sec-dependent and -independent membrane insertion%3B similar to Oxa1p in mitochondria gene gene950 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04745 COSY_RS04750 COSY_0942 COSY_RS04750 986546 987406 + hypothetical protein gene gene951 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04750 COSY_RS04755 COSY_0943 COSY_RS04755 987820 988353 + 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase gene gene952 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04755 COSY_RS04760 COSY_0944 COSY_RS04760 988967 989383 - ATP synthase epsilon chain gene gene953 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04760 COSY_RS04765 COSY_0945 COSY_RS04765 989384 990763 - ATP synthase subunit beta gene gene954 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04765 COSY_RS04770 COSY_0946 COSY_RS04770 990786 991652 - ATP synthase subunit gamma Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit gene gene955 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04770 COSY_RS04775 COSY_0947 COSY_RS04775 991666 993207 - ATP synthase subunit alpha produces ATP from ADP in the presence of a proton gradient across the membrane%3B the alpha chain is a catalytic subunit gene gene956 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04775 COSY_RS04780 COSY_0948 COSY_RS04780 993234 993785 - ATP synthase subunit delta gene gene957 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04780 COSY_RS04785 COSY_0949 COSY_RS04785 993792 994265 - ATP synthase subunit b Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. gene gene958 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04785 COSY_RS04790 COSY_0950 COSY_RS04790 994301 994534 - F0F1 ATP synthase subunit C Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 gene gene959 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04790 COSY_RS04795 COSY_0951 COSY_RS04795 994562 995416 - F0F1 ATP synthase subunit A gene gene960 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04795 COSY_RS04800 COSY_0952 COSY_RS04800 995416 995763 - hypothetical protein gene gene961 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04800 COSY_RS04805 COSY_0953 COSY_RS04805 995954 997240 + pyridine nucleotide-disulfide oxidoreductase gene gene962 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04805 COSY_RS04810 COSY_0954 COSY_RS04810 997967 998785 - NAD+ kinase gene gene963 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04810 COSY_RS04815 COSY_0955 COSY_RS04815 998921 999484 + co-chaperone GrpE gene gene964 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04815 COSY_RS04820 COSY_0956 COSY_RS04820 1000568 1002799 + protein-disulfide reductase gene gene965 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04820 COSY_RS04825 COSY_0957 COSY_RS04825 1002888 1003337 + 3-dehydroquinate dehydratase gene gene966 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04825 COSY_RS04830 COSY_0958 COSY_RS04830 1003338 1003784 + acetyl-CoA carboxylase biotin carboxyl carrier protein subunit gene gene967 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04830 COSY_RS04835 COSY_0959 COSY_RS04835 1003790 1005145 + acetyl-CoA carboxylase biotin carboxylase subunit an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase%2C an enzyme that catalyzes the formation of malonyl-CoA%2C which in turn controls the rate of fatty acid metabolism gene gene968 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04835 COSY_RS04840 COSY_0960 COSY_RS04840 1005142 1006164 + N-acetyl-gamma-glutamyl-phosphate reductase gene gene969 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04840 COSY_RS04845 COSY_0961 COSY_RS04845 1006174 1006527 + iron-sulfur cluster insertion protein ErpA gene gene970 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04845 COSY_RS04850 COSY_0962 COSY_RS04850 1006531 1007667 + citrate synthase catalyzes the formation of citrate from acetyl-CoA and oxaloacetate gene gene971 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04850 COSY_RS04855 COSY_0963 ubiE ubiE 1007670 1008410 + ubiquinone/menaquinone biosynthesis methyltransferase Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone and menaquinone gene gene972 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04855 COSY_RS04860 COSY_0964 COSY_RS04860 1008639 1008968 + hypothetical protein gene gene973 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04860 COSY_RS04865 COSY_0965 COSY_RS04865 1008953 1010557 + ubiquinone biosynthesis protein UbiB gene gene974 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04865 COSY_RS04870 COSY_0966 COSY_RS04870 1010714 1011391 + 50S ribosomal protein L25 gene gene975 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04870 COSY_RS04875 COSY_0967 COSY_RS04875 1011403 1011984 + peptidyl-tRNA hydrolase Enables the recycling of peptidyl-tRNAs produced at termination of translation gene gene976 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04875 COSY_RS04880 COSY_0968 ychF ychF 1011997 1013088 + GTP-binding protein EngD%3B translation-associated GTPase%3B the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3)%3B fluorescence spectroscopy revealed nucleic acid binding%3B the yeast protein YBR025c interacts with the translation elongation factor eEF1 gene gene977 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04880 COSY_RS04885 COSY_0969 COSY_RS04885 1013131 1014669 + 2%2C3-bisphosphoglycerate-independent phosphoglycerate mutase catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gene gene978 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04885 COSY_RS04890 COSY_0970 COSY_RS04890 1014700 1015371 + ribulose-phosphate 3-epimerase gene gene979 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04890 COSY_RS04895 COSY_0971 COSY_RS04895 1015636 1016421 + 30S ribosomal protein S2 gene gene980 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04895 COSY_RS04900 COSY_0972 COSY_RS04900 1016621 1017493 + elongation factor Ts gene gene981 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04900 COSY_RS04905 COSY_0973 COSY_RS04905 1017960 1018484 - hypothetical protein gene gene982 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04905 COSY_RS04910 COSY_0974 COSY_RS04910 1019178 1019588 - hypothetical protein gene gene983 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04910 COSY_RS04915 COSY_t35 COSY_RS04915 1020279 1020364 - tRNA-Leu tRNA gene984 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04915 COSY_RS04920 COSY_0976 COSY_RS04920 1020382 1020750 - preprotein translocase subunit SecG gene gene985 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04920 COSY_RS04925 COSY_0977 COSY_RS04925 1020753 1021499 - triosephosphate isomerase Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate gene gene986 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04925 COSY_RS04930 COSY_0978 COSY_RS04930 1021569 1022087 - membrane protein gene gene987 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04930 COSY_RS04940 COSY_0051 COSY_RS04940 49439 49720 - hypothetical protein gene gene50 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04940 COSY_RS04945 COSY_0052 COSY_RS04945 49850 50515 - hypothetical protein gene gene51 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04945 COSY_RS04950 COSY_0153 COSY_RS04950 164822 166204 + hypothetical protein gene gene151 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04950 COSY_RS04955 COSY_0268 COSY_RS04955 270885 271547 + hypothetical protein gene gene265 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04955 COSY_RS04960 COSY_0654 COSY_RS04960 682738 683028 + hypothetical protein gene gene657 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04960 COSY_RS04965 COSY_0918 COSY_RS04965 956216 956785 + hypothetical protein gene gene926 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04965 COSY_RS04970 COSY_RS04970 COSY_RS04970 754160 754501 - bacterial RNase P ncRNA gene722 http://www.ncbi.nlm.nih.gov/gene/?term=COSY_RS04970