locus-tag	class	description
D8L92_RS00005	COG0287	Prephenate dehydrogenase
D8L92_RS00025	COG1760	l-serine dehydratase
D8L92_RS00030	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D8L92_RS00035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8L92_RS00040	COG1335	isochorismatase
D8L92_RS00050	COG1629	transport
D8L92_RS00060	COG0022	dehydrogenase e1 component
D8L92_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D8L92_RS00085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D8L92_RS00095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D8L92_RS00100	COG1575	Belongs to the MenA family. Type 1 subfamily
D8L92_RS00120	COG0300	oxidoreductase activity
D8L92_RS00125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D8L92_RS00145	COG1595	DNA-templated transcription, initiation
D8L92_RS00160	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D8L92_RS00180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D8L92_RS00185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D8L92_RS00190	COG0440	acetolactate synthase activity
D8L92_RS00195	COG0028	Belongs to the TPP enzyme family
D8L92_RS00200	COG0129	dihydroxy-acid dehydratase activity
D8L92_RS00265	COG0018	arginyl-trna synthetase
D8L92_RS00275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D8L92_RS00280	COG0671	phosphoesterase, PA-phosphatase related
D8L92_RS00300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D8L92_RS00305	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D8L92_RS00315	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8L92_RS00315	COG0022	dehydrogenase e1 component
D8L92_RS00325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D8L92_RS00325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D8L92_RS00330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D8L92_RS00350	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D8L92_RS00355	COG0539	negative regulation of cytoplasmic translation
D8L92_RS00365	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D8L92_RS00375	COG0564	pseudouridine synthase activity
D8L92_RS00380	COG4974	Belongs to the 'phage' integrase family
D8L92_RS00385	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D8L92_RS00415	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D8L92_RS00440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8L92_RS00460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D8L92_RS00470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D8L92_RS00475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D8L92_RS00480	COG0297	glycogen (starch) synthase activity
D8L92_RS00495	COG1595	DNA-templated transcription, initiation
D8L92_RS00525	COG2855	membrane
D8L92_RS00570	COG1396	sequence-specific DNA binding
D8L92_RS00640	COG1741	Belongs to the pirin family
D8L92_RS00690	COG1741	Belongs to the pirin family
D8L92_RS00745	COG0175	sulfate reduction
D8L92_RS00775	COG0544	peptidyl-prolyl cis-trans isomerase activity
D8L92_RS00790	COG0175	sulfate reduction
D8L92_RS00800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D8L92_RS00835	COG2949	membrane
D8L92_RS00850	COG0592	DNA-directed DNA polymerase activity
D8L92_RS00860	COG3591	Belongs to the peptidase S1B family
D8L92_RS00890	COG0512	Glutamine amidotransferase of anthranilate synthase
D8L92_RS00895	COG0134	indole-3-glycerol-phosphate synthase activity
D8L92_RS00900	COG0556	nucleotide-excision repair
D8L92_RS00905	COG0802	atpase or kinase
D8L92_RS00935	COG1629	transport
D8L92_RS00935	COG4206	TonB-dependent receptor
D8L92_RS00990	COG1757	Na H antiporter
D8L92_RS01020	COG1160	GTP binding
D8L92_RS01040	COG4152	abc transporter atp-binding protein
D8L92_RS01045	COG2183	response to ionizing radiation
D8L92_RS01060	COG2884	Cell division ATP-binding protein ftsE
D8L92_RS01065	COG0739	heme binding
D8L92_RS01075	COG0305	Participates in initiation and elongation during chromosome replication
D8L92_RS01080	COG0825	malonyl-CoA metabolic process
D8L92_RS01095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D8L92_RS01110	COG0824	Thioesterase
D8L92_RS01115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D8L92_RS01120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D8L92_RS01125	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D8L92_RS01145	COG0284	orotidine-5'-phosphate decarboxylase activity
D8L92_RS01150	COG1482	cell wall glycoprotein biosynthetic process
D8L92_RS01160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8L92_RS01170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8L92_RS01195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D8L92_RS01200	COG1862	Preprotein translocase
D8L92_RS01205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8L92_RS01210	COG1132	(ABC) transporter
D8L92_RS01215	COG1595	DNA-templated transcription, initiation
D8L92_RS01245	COG4771	TonB-dependent receptor
D8L92_RS01265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D8L92_RS01280	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D8L92_RS01285	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D8L92_RS01295	COG0840	transmembrane signaling receptor activity
D8L92_RS01325	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D8L92_RS01340	COG1805	sodium ion transport
D8L92_RS01345	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D8L92_RS01350	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D8L92_RS01355	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D8L92_RS01390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D8L92_RS01405	COG2226	methyltransferase
D8L92_RS01410	COG4206	TonB-dependent receptor
D8L92_RS01410	COG1629	transport
D8L92_RS01445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D8L92_RS01455	COG3022	response to hydroperoxide
D8L92_RS01475	COG1136	(ABC) transporter
D8L92_RS01490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D8L92_RS01495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8L92_RS01500	COG2986	histidine ammonia-lyase
D8L92_RS01520	COG1595	DNA-templated transcription, initiation
D8L92_RS01555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8L92_RS01565	COG0706	membrane insertase activity
D8L92_RS01590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D8L92_RS01615	COG1301	dicarboxylic acid transport
D8L92_RS01625	COG1506	peptidase
D8L92_RS01625	COG0823	Involved in the tonB-independent uptake of proteins
D8L92_RS01630	COG1629	transport
D8L92_RS01630	COG4206	TonB-dependent receptor
D8L92_RS01640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8L92_RS01675	COG0268	Binds directly to 16S ribosomal RNA
D8L92_RS01685	COG1381	Involved in DNA repair and RecF pathway recombination
D8L92_RS01690	COG2261	transglycosylase associated protein
D8L92_RS01695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D8L92_RS01700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D8L92_RS01710	COG3956	TIGRFAM MazG family protein
D8L92_RS01720	COG0577	efflux transmembrane transporter activity
D8L92_RS01735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8L92_RS01775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D8L92_RS01820	COG1733	regulation of RNA biosynthetic process
D8L92_RS01870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D8L92_RS01880	COG1652	LysM domain
D8L92_RS01895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D8L92_RS01900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D8L92_RS01910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D8L92_RS01915	COG0745	RESPONSE REGULATOR receiver
D8L92_RS01915	COG2972	Histidine kinase
D8L92_RS01920	COG2201	protein-glutamate methylesterase activity
D8L92_RS01940	COG0156	8-amino-7-oxononanoate synthase activity
D8L92_RS02000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8L92_RS02005	COG0488	(ABC) transporter
D8L92_RS02010	COG0598	Magnesium transport protein CorA
D8L92_RS02035	COG0433	COG0433 Predicted ATPase
D8L92_RS02040	COG0791	NLP P60 protein
D8L92_RS02050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D8L92_RS02060	COG0205	6-phosphofructokinase activity
D8L92_RS02105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D8L92_RS02110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D8L92_RS02115	COG0328	RNA-DNA hybrid ribonuclease activity
D8L92_RS02115	COG3341	Caulimovirus viroplasmin
D8L92_RS02130	COG4948	Mandelate Racemase Muconate Lactonizing
D8L92_RS02170	COG1705	Flagellar rod assembly protein muramidase FlgJ
D8L92_RS02170	COG1388	LysM domain
D8L92_RS02175	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D8L92_RS02180	COG1696	Membrane protein involved in D-alanine export
D8L92_RS02190	COG0488	(ABC) transporter
D8L92_RS02205	COG0497	DNA recombination
D8L92_RS02215	COG2234	aminopeptidase activity
D8L92_RS02225	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D8L92_RS02235	COG1131	(ABC) transporter
D8L92_RS02240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D8L92_RS02245	COG0438	transferase activity, transferring glycosyl groups
D8L92_RS02250	COG5434	Belongs to the glycosyl hydrolase 28 family
D8L92_RS02265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D8L92_RS02270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8L92_RS02280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D8L92_RS02285	COG1678	Uncharacterized ACR, COG1678
D8L92_RS02300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D8L92_RS02320	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
D8L92_RS02325	COG3621	Patatin-like phospholipase
D8L92_RS02385	COG1132	(ABC) transporter
D8L92_RS02390	COG1132	(ABC) transporter
D8L92_RS02420	COG4974	Belongs to the 'phage' integrase family
D8L92_RS02435	COG0629	single-stranded DNA binding
D8L92_RS02560	COG0758	DNA mediated transformation
D8L92_RS02660	COG3501	Rhs element vgr protein
D8L92_RS02745	COG0542	response to heat
D8L92_RS02785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D8L92_RS02810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D8L92_RS02820	COG2195	Cleaves the N-terminal amino acid of tripeptides
D8L92_RS02830	COG0009	L-threonylcarbamoyladenylate synthase
D8L92_RS02835	COG0583	DNA-binding transcription factor activity
D8L92_RS02840	COG0783	Belongs to the Dps family
D8L92_RS02845	COG2860	membrane
D8L92_RS02855	COG3340	Belongs to the peptidase S51 family
D8L92_RS02865	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D8L92_RS02870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D8L92_RS02885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D8L92_RS02890	COG0737	Belongs to the 5'-nucleotidase family
D8L92_RS02895	COG0737	Belongs to the 5'-nucleotidase family
D8L92_RS02905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8L92_RS02910	COG0686	Belongs to the AlaDH PNT family
D8L92_RS02925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D8L92_RS02930	COG0776	regulation of translation
D8L92_RS02945	COG2326	polyphosphate kinase activity
D8L92_RS02960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D8L92_RS02965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D8L92_RS02970	COG0482	sulfurtransferase activity
D8L92_RS02975	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D8L92_RS02980	COG1522	sequence-specific DNA binding
D8L92_RS03010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D8L92_RS03020	COG1522	sequence-specific DNA binding
D8L92_RS03040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D8L92_RS03115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D8L92_RS03120	COG0363	glucosamine-6-phosphate deaminase activity
D8L92_RS03135	COG3209	COG3209 Rhs family protein
D8L92_RS03140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D8L92_RS03145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D8L92_RS03150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D8L92_RS03165	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D8L92_RS03170	COG0534	Mate efflux family protein
D8L92_RS03175	COG0542	response to heat
D8L92_RS03180	COG0791	NLP P60 protein
D8L92_RS03185	COG2333	competence protein COMEC
D8L92_RS03185	COG0658	competence protein
D8L92_RS03190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D8L92_RS03205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D8L92_RS03240	COG0504	CTP synthase activity
D8L92_RS03245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D8L92_RS03255	COG1346	cytolysis
D8L92_RS03275	COG1611	Belongs to the LOG family
D8L92_RS03290	COG4717	serine-type aminopeptidase activity
D8L92_RS03345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D8L92_RS03350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D8L92_RS03360	COG0343	queuine tRNA-ribosyltransferase activity
D8L92_RS03370	COG0187	DNA topoisomerase II activity
D8L92_RS03410	COG2304	oxidoreductase activity
D8L92_RS03425	COG0714	Associated with various cellular activities
D8L92_RS03440	COG0471	metal ion transport
D8L92_RS03460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D8L92_RS03470	COG1054	Belongs to the UPF0176 family
D8L92_RS03475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D8L92_RS03485	COG0514	ATP-dependent DNA helicase (RecQ)
D8L92_RS03490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D8L92_RS03490	COG0517	IMP dehydrogenase activity
D8L92_RS03495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D8L92_RS03500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D8L92_RS03505	COG0052	Belongs to the universal ribosomal protein uS2 family
D8L92_RS03510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D8L92_RS03515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D8L92_RS03520	COG4771	TonB-dependent receptor
D8L92_RS03595	COG0753	catalase activity
D8L92_RS03600	COG0745	RESPONSE REGULATOR receiver
D8L92_RS03605	COG5002	protein histidine kinase activity
D8L92_RS03620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D8L92_RS03625	COG1266	CAAX protease self-immunity
D8L92_RS03635	COG2234	aminopeptidase activity
D8L92_RS03640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D8L92_RS03650	COG0436	Aminotransferase
D8L92_RS03720	COG4974	Belongs to the 'phage' integrase family
D8L92_RS03730	COG0488	(ABC) transporter
D8L92_RS03785	COG0133	tryptophan synthase activity
D8L92_RS03795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D8L92_RS03800	COG0527	aspartate kinase activity
D8L92_RS03815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D8L92_RS03940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D8L92_RS03985	COG1193	negative regulation of DNA recombination
D8L92_RS04000	COG1695	Transcriptional regulator
D8L92_RS04015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D8L92_RS04025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D8L92_RS04040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D8L92_RS04045	COG1078	dGTPase activity
D8L92_RS04050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8L92_RS04055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D8L92_RS04055	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D8L92_RS04060	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8L92_RS04065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D8L92_RS04075	COG2502	aspartate--ammonia ligase
D8L92_RS04080	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8L92_RS04085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D8L92_RS04090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D8L92_RS04095	COG1181	Belongs to the D-alanine--D-alanine ligase family
D8L92_RS04110	COG0793	Belongs to the peptidase S41A family
D8L92_RS04145	COG1104	cysteine desulfurase activity
D8L92_RS04170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D8L92_RS04200	COG2843	Capsule synthesis protein
D8L92_RS04205	COG0196	riboflavin kinase activity
D8L92_RS04215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D8L92_RS04240	COG0730	response to heat
D8L92_RS04255	COG3152	Membrane
D8L92_RS04285	COG1217	gtp-binding protein TYPA
D8L92_RS04340	COG4166	transmembrane transport
D8L92_RS04375	COG2197	response regulator
D8L92_RS04445	COG0542	response to heat
D8L92_RS04585	COG4104	PAAR repeat-containing protein
D8L92_RS04585	COG3209	COG3209 Rhs family protein
D8L92_RS04655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D8L92_RS04665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D8L92_RS04680	COG0602	queuosine metabolic process
D8L92_RS04695	COG1418	mRNA catabolic process
D8L92_RS04700	COG2885	chlorophyll binding
D8L92_RS04735	COG0671	phosphoesterase, PA-phosphatase related
D8L92_RS04745	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D8L92_RS04760	COG0857	belongs to the CobB CobQ family
D8L92_RS04760	COG0280	phosphate acetyltransferase
D8L92_RS04765	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D8L92_RS04780	COG2356	endonuclease I
D8L92_RS04785	COG4591	ABC-type transport system involved in lipoprotein release permease component
D8L92_RS04790	COG3876	Protein conserved in bacteria
D8L92_RS04795	COG0424	maF-like protein
D8L92_RS04800	COG1028	Short-chain dehydrogenase reductase Sdr
D8L92_RS04830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D8L92_RS04845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8L92_RS04850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D8L92_RS04855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D8L92_RS04860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D8L92_RS04865	COG0259	pyridoxamine-phosphate oxidase activity
D8L92_RS04870	COG1234	tRNA 3'-trailer cleavage
D8L92_RS04880	COG0540	Belongs to the ATCase OTCase family
D8L92_RS04900	COG0588	phosphoglycerate mutase activity
D8L92_RS04920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D8L92_RS04935	COG1899	peptidyl-lysine modification to peptidyl-hypusine
D8L92_RS04940	COG0010	Belongs to the arginase family
D8L92_RS04945	COG1166	arginine decarboxylase activity
D8L92_RS04950	COG0488	(ABC) transporter
D8L92_RS04975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D8L92_RS04980	COG1702	phosphate starvation-inducible protein PhoH
D8L92_RS04990	COG2195	Cleaves the N-terminal amino acid of tripeptides
D8L92_RS04995	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D8L92_RS05000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D8L92_RS05015	COG2177	Part of the ABC transporter FtsEX involved in
D8L92_RS05025	COG1968	undecaprenyl-diphosphatase activity
D8L92_RS05035	COG0084	hydrolase, TatD family'
D8L92_RS05045	COG0252	asparaginase activity
D8L92_RS05055	COG0811	peptide transport
D8L92_RS05080	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D8L92_RS05085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D8L92_RS05105	COG0516	GMP reductase activity
D8L92_RS05105	COG0517	IMP dehydrogenase activity
D8L92_RS05140	COG1785	Belongs to the alkaline phosphatase family
D8L92_RS05145	COG0438	transferase activity, transferring glycosyl groups
D8L92_RS05150	COG0463	Glycosyl transferase, family 2
D8L92_RS05180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D8L92_RS05190	COG2363	Small membrane protein
D8L92_RS05195	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D8L92_RS05205	COG1522	sequence-specific DNA binding
D8L92_RS05210	COG1428	Deoxynucleoside kinase
D8L92_RS05215	COG3250	beta-galactosidase activity
D8L92_RS05220	COG0561	phosphatase activity
D8L92_RS05245	COG3842	ATPase activity
D8L92_RS05260	COG0653	protein targeting
D8L92_RS05270	COG2239	Acts as a magnesium transporter
D8L92_RS05285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D8L92_RS05295	COG1595	DNA-templated transcription, initiation
D8L92_RS05305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D8L92_RS05310	COG0386	Belongs to the glutathione peroxidase family
D8L92_RS05375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D8L92_RS05380	COG1022	Amp-dependent synthetase and ligase
D8L92_RS05390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D8L92_RS05410	COG3119	arylsulfatase activity
D8L92_RS05415	COG1132	(ABC) transporter
D8L92_RS05420	COG4771	TonB-dependent receptor
D8L92_RS05430	COG3059	membrane
D8L92_RS05435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D8L92_RS05435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D8L92_RS05460	COG3935	DnaD domain protein
D8L92_RS05485	COG1739	Uncharacterized protein family UPF0029
D8L92_RS05490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8L92_RS05490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8L92_RS05495	COG2890	protein-(glutamine-N5) methyltransferase activity
D8L92_RS05505	COG0552	protein localization to endoplasmic reticulum
D8L92_RS05515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D8L92_RS05520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D8L92_RS05525	COG0179	Fumarylacetoacetate (FAA) hydrolase
D8L92_RS05585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D8L92_RS05595	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D8L92_RS05610	COG0848	biopolymer transport protein
D8L92_RS05615	COG0811	peptide transport
D8L92_RS05620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D8L92_RS05630	COG0019	diaminopimelate decarboxylase activity
D8L92_RS05635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D8L92_RS05640	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8L92_RS05650	COG0047	phosphoribosylformylglycinamidine synthase activity
D8L92_RS05650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D8L92_RS05655	COG0488	(ABC) transporter
D8L92_RS05660	COG3119	arylsulfatase activity
D8L92_RS05665	COG0167	dihydroorotate dehydrogenase activity
D8L92_RS05685	COG1803	Methylglyoxal synthase
D8L92_RS05695	COG2264	protein methyltransferase activity
D8L92_RS05700	COG1137	ATPase activity
D8L92_RS05710	COG0805	protein transport
D8L92_RS05755	COG2050	protein possibly involved in aromatic compounds catabolism
D8L92_RS05765	COG0336	Belongs to the RNA methyltransferase TrmD family
D8L92_RS05785	COG0519	Catalyzes the synthesis of GMP from XMP
D8L92_RS05785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D8L92_RS05860	COG0840	transmembrane signaling receptor activity
D8L92_RS05870	COG1858	cytochrome C peroxidase
D8L92_RS05875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D8L92_RS05875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D8L92_RS05880	COG3537	Alpha-1,2-mannosidase
D8L92_RS05885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D8L92_RS05895	COG0322	excinuclease ABC activity
D8L92_RS05900	COG0335	large ribosomal subunit rRNA binding
D8L92_RS05920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D8L92_RS05935	COG0443	Heat shock 70 kDa protein
D8L92_RS05965	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D8L92_RS05970	COG0427	acetyl-CoA hydrolase
D8L92_RS05985	COG1674	ftsk spoiiie
D8L92_RS05990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D8L92_RS05990	COG2111	Na H antiporter
D8L92_RS05995	COG2111	Na H antiporter
D8L92_RS06005	COG1006	Multisubunit Na H antiporter MnhC subunit
D8L92_RS06010	COG0651	ATP synthesis coupled electron transport
D8L92_RS06015	COG1863	multisubunit Na H antiporter MnhE subunit
D8L92_RS06020	COG2212	antiporter activity
D8L92_RS06025	COG1320	monovalent cation:proton antiporter activity
D8L92_RS06035	COG0191	fructose-bisphosphate aldolase activity
D8L92_RS06040	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D8L92_RS06050	COG0606	chelatase, subunit chli
D8L92_RS06055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D8L92_RS06095	COG0247	lactate metabolic process
D8L92_RS06095	COG2181	nitrate reductase activity
D8L92_RS06100	COG0247	lactate metabolic process
D8L92_RS06100	COG2181	nitrate reductase activity
D8L92_RS06110	COG0860	N-Acetylmuramoyl-L-alanine amidase
D8L92_RS06115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D8L92_RS06120	COG0251	oxidation-reduction process
D8L92_RS06150	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D8L92_RS06160	COG0222	ribosome binding
D8L92_RS06165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D8L92_RS06170	COG0081	regulation of translation
D8L92_RS06175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D8L92_RS06225	COG2194	sulfuric ester hydrolase activity
D8L92_RS06235	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D8L92_RS06240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D8L92_RS06255	COG0756	dUTP diphosphatase activity
D8L92_RS06285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8L92_RS06290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D8L92_RS06295	COG0628	permease
D8L92_RS06305	COG0681	Belongs to the peptidase S26 family
D8L92_RS06320	COG1854	S-ribosylhomocysteine lyase activity
D8L92_RS06325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D8L92_RS06330	COG5002	protein histidine kinase activity
D8L92_RS06335	COG0745	RESPONSE REGULATOR receiver
D8L92_RS06345	COG1090	epimerase
D8L92_RS06350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D8L92_RS06360	COG1475	DNA binding
D8L92_RS06365	COG1192	Involved in chromosome partitioning
D8L92_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
D8L92_RS06375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D8L92_RS06380	COG1663	tetraacyldisaccharide 4'-kinase activity
D8L92_RS06390	COG2137	regulation of response to DNA damage stimulus
D8L92_RS06395	COG0708	Exodeoxyribonuclease III
D8L92_RS06400	COG0339	signal peptide processing
D8L92_RS06415	COG0702	epimerase
D8L92_RS06420	COG1629	transport
D8L92_RS06425	COG3250	beta-galactosidase activity
D8L92_RS06430	COG3119	arylsulfatase activity
D8L92_RS06440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D8L92_RS06455	COG0166	Belongs to the GPI family
D8L92_RS06475	COG1215	transferase activity, transferring glycosyl groups
D8L92_RS06480	COG2255	four-way junction helicase activity
D8L92_RS06490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D8L92_RS06500	COG1187	pseudouridine synthase activity
D8L92_RS06510	COG3142	Participates in the control of copper homeostasis
D8L92_RS06530	COG0450	alkyl hydroperoxide reductase
D8L92_RS06535	COG0484	heat shock protein binding
D8L92_RS06540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D8L92_RS06545	COG0561	phosphatase activity
D8L92_RS06550	COG0360	Binds together with S18 to 16S ribosomal RNA
D8L92_RS06555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D8L92_RS06560	COG0359	binds to the 23S rRNA
D8L92_RS06615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8L92_RS06615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8L92_RS06635	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D8L92_RS06640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D8L92_RS06665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D8L92_RS06675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D8L92_RS06680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D8L92_RS06690	COG0242	peptide deformylase activity
D8L92_RS06715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D8L92_RS06735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D8L92_RS06740	COG4953	penicillin-binding protein 1C
D8L92_RS06765	COG1114	Component of the transport system for branched-chain amino acids
D8L92_RS06775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D8L92_RS06790	COG0442	prolyl-tRNA aminoacylation
D8L92_RS06800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D8L92_RS06800	COG0321	lipoyl(octanoyl) transferase activity
D8L92_RS06805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D8L92_RS06810	COG0228	four-way junction DNA binding
D8L92_RS06820	COG1040	competence protein
D8L92_RS06825	COG0423	glycine-tRNA ligase activity
D8L92_RS06840	COG0436	Aminotransferase
D8L92_RS06865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D8L92_RS06880	COG0321	lipoyl(octanoyl) transferase activity
D8L92_RS06885	COG2321	neutral zinc metallopeptidase
D8L92_RS06890	COG0594	ribonuclease P activity
D8L92_RS06900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D8L92_RS06910	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D8L92_RS06915	COG3005	denitrification pathway
D8L92_RS06930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D8L92_RS06975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D8L92_RS06980	COG3263	regulation of cellular component size
D8L92_RS07000	COG3586	endonuclease activity
D8L92_RS07015	COG0495	leucyl-tRNA aminoacylation
D8L92_RS07030	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D8L92_RS07030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D8L92_RS07040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D8L92_RS07045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D8L92_RS07070	COG0437	4 iron, 4 sulfur cluster binding
D8L92_RS07080	COG0281	malic enzyme
D8L92_RS07080	COG0280	phosphate acetyltransferase
D8L92_RS07085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D8L92_RS07095	COG2271	Major facilitator Superfamily
D8L92_RS07105	COG2076	Multidrug Resistance protein
D8L92_RS07110	COG0564	pseudouridine synthase activity
D8L92_RS07120	COG1950	PFAM Membrane protein of
D8L92_RS07130	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D8L92_RS07140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D8L92_RS07145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D8L92_RS07155	COG0180	Tryptophanyl-tRNA synthetase
D8L92_RS07160	COG0396	ATPase activity
D8L92_RS07185	COG0719	Fe-S assembly protein
D8L92_RS07195	COG0316	Belongs to the HesB IscA family
D8L92_RS07200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D8L92_RS07215	COG0116	Belongs to the methyltransferase superfamily
D8L92_RS07230	COG0527	aspartate kinase activity
D8L92_RS07230	COG0460	homoserine dehydrogenase
D8L92_RS07235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8L92_RS07260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D8L92_RS07265	COG3339	Conserved Protein
D8L92_RS07270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D8L92_RS07275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D8L92_RS07290	COG1477	protein flavinylation
D8L92_RS07300	COG0813	purine-nucleoside phosphorylase activity
D8L92_RS07305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D8L92_RS07325	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D8L92_RS07330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D8L92_RS07370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D8L92_RS07385	COG0339	signal peptide processing
D8L92_RS07400	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D8L92_RS07400	COG0662	Cupin 2, conserved barrel domain protein
D8L92_RS07410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D8L92_RS07425	COG0612	Peptidase, M16
D8L92_RS07430	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D8L92_RS07470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D8L92_RS07485	COG3655	Transcriptional regulator
D8L92_RS07510	COG4335	DNA alkylation repair
D8L92_RS07515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D8L92_RS07545	COG0348	domain, Protein
D8L92_RS07550	COG2010	Cytochrome c
D8L92_RS07570	COG2217	Heavy metal translocating P-type atpase
D8L92_RS07575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8L92_RS07620	COG0358	DNA primase activity
D8L92_RS07625	COG0393	Putative heavy-metal-binding
D8L92_RS07645	COG1022	Amp-dependent synthetase and ligase
D8L92_RS07665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D8L92_RS07670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D8L92_RS07680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D8L92_RS07690	COG5000	phosphorelay sensor kinase activity
D8L92_RS07705	COG0149	triose-phosphate isomerase activity
D8L92_RS07710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D8L92_RS07715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D8L92_RS07735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D8L92_RS07755	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D8L92_RS07765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8L92_RS07800	COG4942	peptidase
D8L92_RS07810	COG2001	Belongs to the MraZ family
D8L92_RS07815	COG0275	rRNA processing
D8L92_RS07900	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D8L92_RS07950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D8L92_RS07970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D8L92_RS07985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D8L92_RS07990	COG0772	Belongs to the SEDS family
D8L92_RS07995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D8L92_RS08005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D8L92_RS08020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D8L92_RS08030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D8L92_RS08070	COG0768	penicillin binding
D8L92_RS08090	COG0138	bifunctional purine biosynthesis protein purh
D8L92_RS08100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D8L92_RS08105	COG1185	polyribonucleotide nucleotidyltransferase activity
D8L92_RS08110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D8L92_RS08115	COG1501	Belongs to the glycosyl hydrolase 31 family
D8L92_RS08125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D8L92_RS08140	COG0445	tRNA wobble uridine modification
D8L92_RS08150	COG0322	excinuclease ABC activity
D8L92_RS08155	COG1490	D-aminoacyl-tRNA deacylase activity
D8L92_RS08185	COG0463	Glycosyl transferase, family 2
D8L92_RS08195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D8L92_RS08220	COG1288	antiporter activity
D8L92_RS08250	COG0420	3'-5' exonuclease activity
D8L92_RS08255	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D8L92_RS08265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D8L92_RS08270	COG0124	histidyl-tRNA synthetase
D8L92_RS08280	COG2171	N-acyltransferase activity
D8L92_RS08285	COG0750	zinc metalloprotease
D8L92_RS08425	COG1082	Xylose isomerase domain protein TIM barrel
D8L92_RS08450	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D8L92_RS08455	COG4206	TonB-dependent receptor
D8L92_RS08455	COG1629	transport
D8L92_RS08460	COG1609	Transcriptional regulator
D8L92_RS08465	COG0366	Alpha amylase catalytic
D8L92_RS08470	COG1554	hydrolase, family 65, central catalytic
D8L92_RS08490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D8L92_RS08510	COG1091	dTDP-4-dehydrorhamnose reductase activity
D8L92_RS08540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D8L92_RS08545	COG1028	Short-chain dehydrogenase reductase Sdr
D8L92_RS08565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D8L92_RS08580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D8L92_RS08610	COG2954	triphosphatase activity
D8L92_RS08615	COG0481	GTPase activity
D8L92_RS08635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D8L92_RS08645	COG2322	membrane
D8L92_RS08650	COG1999	signal sequence binding
D8L92_RS08665	COG0346	lactoylglutathione lyase activity
D8L92_RS08680	COG2151	metal-sulfur cluster biosynthetic enzyme
D8L92_RS08685	COG2166	iron-sulfur cluster assembly
D8L92_RS08690	COG0792	nuclease activity
D8L92_RS08695	COG1074	ATP-dependent DNA helicase activity
D8L92_RS08730	COG0702	epimerase
D8L92_RS08750	COG0632	four-way junction helicase activity
D8L92_RS08760	COG0563	adenylate kinase activity
D8L92_RS08765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D8L92_RS08785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D8L92_RS08815	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D8L92_RS08835	COG1607	acyl-coa hydrolase
D8L92_RS08915	COG0673	inositol 2-dehydrogenase activity
D8L92_RS08925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D8L92_RS08930	COG1349	DNA-binding transcription factor activity
D8L92_RS08950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D8L92_RS08960	COG0429	hydrolase of the alpha beta-hydrolase fold
D8L92_RS08970	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
D8L92_RS08980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D8L92_RS09010	COG3201	nicotinamide mononucleotide transporter
D8L92_RS09045	COG0686	Belongs to the AlaDH PNT family
D8L92_RS09105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D8L92_RS09115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D8L92_RS09135	COG0557	exoribonuclease II activity
D8L92_RS09140	COG1629	transport
D8L92_RS09145	COG4771	TonB-dependent receptor
D8L92_RS09175	COG5492	domain, Protein
D8L92_RS09180	COG4172	Belongs to the ABC transporter superfamily
D8L92_RS09190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D8L92_RS09195	COG1214	PFAM Peptidase M22, glycoprotease
D8L92_RS09245	COG0193	aminoacyl-tRNA hydrolase activity
D8L92_RS09250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D8L92_RS09260	COG0252	asparaginase activity
D8L92_RS09265	COG4771	TonB-dependent receptor
D8L92_RS09290	COG0826	peptidase U32
D8L92_RS09310	COG2304	oxidoreductase activity
D8L92_RS09315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D8L92_RS09320	COG3537	Alpha-1,2-mannosidase
D8L92_RS09330	COG1755	Isoprenylcysteine carboxyl methyltransferase
D8L92_RS09350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8L92_RS09385	COG1519	Transferase
D8L92_RS09440	COG0668	transmembrane transport
D8L92_RS09465	COG0109	protoheme IX farnesyltransferase activity
D8L92_RS09480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D8L92_RS09490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D8L92_RS09500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8L92_RS09505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D8L92_RS09515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D8L92_RS09520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D8L92_RS09530	COG0758	DNA mediated transformation
D8L92_RS09530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D8L92_RS09535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D8L92_RS09540	COG0668	transmembrane transport
D8L92_RS09575	COG0459	protein refolding
D8L92_RS09580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D8L92_RS09605	COG1505	serine-type exopeptidase activity
D8L92_RS09610	COG1774	PSP1 C-terminal conserved region
D8L92_RS09620	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D8L92_RS09625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D8L92_RS09670	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D8L92_RS09675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D8L92_RS09700	COG0629	single-stranded DNA binding
D8L92_RS09710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D8L92_RS09715	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D8L92_RS09740	COG2824	Alkylphosphonate utilization operon protein PhnA
D8L92_RS09755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D8L92_RS09760	COG0633	Ferredoxin
D8L92_RS09770	COG0492	ferredoxin-NADP+ reductase activity
D8L92_RS09785	COG0489	protein tyrosine kinase activity
D8L92_RS09790	COG1114	Component of the transport system for branched-chain amino acids
D8L92_RS09795	COG0306	phosphate transporter
D8L92_RS09805	COG0151	Belongs to the GarS family
D8L92_RS09815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D8L92_RS09845	COG0356	it plays a direct role in the translocation of protons across the membrane
D8L92_RS09850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D8L92_RS09855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D8L92_RS09860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D8L92_RS09865	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D8L92_RS09870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D8L92_RS09885	COG0126	phosphoglycerate kinase activity
D8L92_RS09890	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8L92_RS09900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D8L92_RS09910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D8L92_RS09915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8L92_RS09935	COG0509	glycine decarboxylation via glycine cleavage system
D8L92_RS09940	COG0006	proline dipeptidase activity
D8L92_RS09980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D8L92_RS09990	COG0439	Biotin carboxylase
D8L92_RS09995	COG1162	GTPase activity
D8L92_RS10000	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D8L92_RS10005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D8L92_RS10015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8L92_RS10040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D8L92_RS10050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D8L92_RS10065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8L92_RS10100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D8L92_RS10135	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D8L92_RS10150	COG1053	succinate dehydrogenase
D8L92_RS10175	COG0840	transmembrane signaling receptor activity
D8L92_RS10180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D8L92_RS10200	COG3250	beta-galactosidase activity
D8L92_RS10225	COG0017	Asparaginyl-tRNA synthetase
D8L92_RS10230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D8L92_RS10250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D8L92_RS10250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8L92_RS10260	COG1530	ribonuclease E activity
D8L92_RS10265	COG0776	regulation of translation
D8L92_RS10280	COG1999	signal sequence binding
D8L92_RS10295	COG0469	pyruvate kinase activity
D8L92_RS10305	COG0571	ribonuclease III activity
D8L92_RS10310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D8L92_RS10315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D8L92_RS10320	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D8L92_RS10325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D8L92_RS10330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D8L92_RS10335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D8L92_RS10345	COG0719	Fe-S assembly protein
D8L92_RS10365	COG0567	Dehydrogenase, E1 component
D8L92_RS10375	COG0470	DNA polymerase III
D8L92_RS10380	COG0156	8-amino-7-oxononanoate synthase activity
D8L92_RS10385	COG2885	chlorophyll binding
D8L92_RS10410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D8L92_RS10440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D8L92_RS10450	COG1960	acyl-CoA dehydrogenase activity
D8L92_RS10470	COG0463	Glycosyl transferase, family 2
D8L92_RS10475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D8L92_RS10495	COG0542	response to heat
D8L92_RS10500	COG1028	Short-chain dehydrogenase reductase Sdr
D8L92_RS10510	COG0742	ribosomal rna small subunit methyltransferase
D8L92_RS10535	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D8L92_RS10540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D8L92_RS10545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D8L92_RS10550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D8L92_RS10555	COG0195	Participates in both transcription termination and antitermination
D8L92_RS10555	COG2251	uridine kinase activity
D8L92_RS10560	COG0779	Required for maturation of 30S ribosomal subunits
D8L92_RS10565	COG0589	response to stress
D8L92_RS10575	COG0181	hydroxymethylbilane synthase activity
D8L92_RS10580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D8L92_RS10590	COG2373	Large extracellular alpha-helical protein
D8L92_RS10650	COG1131	(ABC) transporter
D8L92_RS10655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8L92_RS10660	COG1027	Aspartate ammonia-lyase
D8L92_RS10670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D8L92_RS10675	COG2226	methyltransferase
D8L92_RS10685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D8L92_RS10700	COG1446	asparaginase
D8L92_RS10710	COG1396	sequence-specific DNA binding
D8L92_RS10720	COG2827	Endonuclease containing a URI domain
D8L92_RS10725	COG1629	transport
D8L92_RS10740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D8L92_RS10750	COG2020	methyltransferase activity
D8L92_RS10815	COG0215	cysteine-tRNA ligase activity
D8L92_RS10825	COG0302	gtp cyclohydrolase
D8L92_RS10830	COG0113	porphobilinogen synthase activity
D8L92_RS10835	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D8L92_RS10855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D8L92_RS10890	COG0720	synthase
D8L92_RS10895	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8L92_RS10925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D8L92_RS10930	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D8L92_RS10935	COG3537	Alpha-1,2-mannosidase
D8L92_RS10950	COG0438	transferase activity, transferring glycosyl groups
D8L92_RS10995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D8L92_RS11000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D8L92_RS11005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D8L92_RS11015	COG0105	UTP biosynthetic process
D8L92_RS11020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D8L92_RS11025	COG0492	ferredoxin-NADP+ reductase activity
D8L92_RS11035	COG0490	domain, Protein
D8L92_RS11035	COG0471	metal ion transport
D8L92_RS11045	COG0326	Molecular chaperone. Has ATPase activity
D8L92_RS11055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D8L92_RS11060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D8L92_RS11065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D8L92_RS11070	COG0194	GDP metabolic process
D8L92_RS11075	COG1561	YicC-like family, N-terminal region
D8L92_RS11080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D8L92_RS11085	COG0049	tRNA binding
D8L92_RS11090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D8L92_RS11095	COG0051	transcription antitermination factor activity, RNA binding
D8L92_RS11100	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D8L92_RS11105	COG0088	Forms part of the polypeptide exit tunnel
D8L92_RS11110	COG0089	rRNA binding
D8L92_RS11115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D8L92_RS11120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D8L92_RS11125	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D8L92_RS11130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D8L92_RS11135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D8L92_RS11140	COG0255	Belongs to the universal ribosomal protein uL29 family
D8L92_RS11145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D8L92_RS11150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D8L92_RS11155	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D8L92_RS11160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D8L92_RS11165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D8L92_RS11170	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D8L92_RS11175	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D8L92_RS11180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D8L92_RS11185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D8L92_RS11190	COG1841	ribosomal large subunit assembly
D8L92_RS11195	COG0200	Binds to the 23S rRNA
D8L92_RS11200	COG0201	protein transport
D8L92_RS11205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D8L92_RS11210	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D8L92_RS11215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D8L92_RS11220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D8L92_RS11230	COG0202	RNA polymerase activity
D8L92_RS11235	COG0203	ribosomal protein L17
D8L92_RS11240	COG0505	Belongs to the CarA family
D8L92_RS11250	COG0148	phosphopyruvate hydratase activity
D8L92_RS11255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D8L92_RS11260	COG1970	mechanosensitive ion channel activity
D8L92_RS11265	COG0616	signal peptide processing
D8L92_RS11270	COG1428	Deoxynucleoside kinase
D8L92_RS11280	COG2186	Transcriptional regulator
D8L92_RS11325	COG1012	belongs to the aldehyde dehydrogenase family
D8L92_RS11335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D8L92_RS11350	COG0799	negative regulation of ribosome biogenesis
D8L92_RS11355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D8L92_RS11365	COG0575	Belongs to the CDS family
D8L92_RS11370	COG0688	phosphatidylethanolamine metabolic process
D8L92_RS11375	COG0217	transcriptional regulatory protein
D8L92_RS11385	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D8L92_RS11385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8L92_RS11390	COG0288	reversible hydration of carbon dioxide
D8L92_RS11395	COG3264	Mechanosensitive ion channel
D8L92_RS11395	COG1511	domain protein
D8L92_RS11405	COG0525	valine-tRNA ligase activity
D8L92_RS11480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D8L92_RS11525	COG1506	peptidase
D8L92_RS11525	COG0823	Involved in the tonB-independent uptake of proteins
D8L92_RS11535	COG3104	oligopeptide transport
D8L92_RS11540	COG1132	(ABC) transporter
D8L92_RS11545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8L92_RS11575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D8L92_RS11590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D8L92_RS11595	COG1136	(ABC) transporter
D8L92_RS11605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D8L92_RS11610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D8L92_RS11620	COG0528	UMP kinase activity
D8L92_RS11625	COG0233	cytoplasmic translational termination
D8L92_RS11630	COG2261	transglycosylase associated protein
D8L92_RS11650	COG1610	YqeY-like protein
D8L92_RS11655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D8L92_RS11660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D8L92_RS11665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D8L92_RS11670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D8L92_RS11675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D8L92_RS11680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit