locus-tag	class	description
CGC53_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CGC53_RS00010	COG0686	Belongs to the AlaDH PNT family
CGC53_RS00015	COG0514	ATP-dependent DNA helicase (RecQ)
CGC53_RS00025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CGC53_RS00030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CGC53_RS00035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CGC53_RS00040	COG0194	GDP metabolic process
CGC53_RS00045	COG1561	YicC-like family, N-terminal region
CGC53_RS00080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CGC53_RS00080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CGC53_RS00085	COG0242	peptide deformylase activity
CGC53_RS00090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CGC53_RS00100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CGC53_RS00105	COG0450	alkyl hydroperoxide reductase
CGC53_RS00115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CGC53_RS00155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CGC53_RS00175	COG0482	sulfurtransferase activity
CGC53_RS00195	COG0101	tRNA pseudouridine synthase activity
CGC53_RS00205	COG0357	Ribosomal RNA small subunit methyltransferase G
CGC53_RS00215	COG0598	Magnesium transport protein CorA
CGC53_RS00230	COG0471	metal ion transport
CGC53_RS00260	COG2184	nucleotidyltransferase activity
CGC53_RS00280	COG0488	(ABC) transporter
CGC53_RS00295	COG1401	restriction endodeoxyribonuclease activity
CGC53_RS00300	COG1522	sequence-specific DNA binding
CGC53_RS00320	COG0497	DNA recombination
CGC53_RS00330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CGC53_RS00330	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CGC53_RS00340	COG0433	COG0433 Predicted ATPase
CGC53_RS00355	COG1381	Involved in DNA repair and RecF pathway recombination
CGC53_RS00360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CGC53_RS00365	COG0009	L-threonylcarbamoyladenylate synthase
CGC53_RS00370	COG1289	transmembrane transporter activity
CGC53_RS00385	COG0359	binds to the 23S rRNA
CGC53_RS00390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CGC53_RS00395	COG0360	Binds together with S18 to 16S ribosomal RNA
CGC53_RS00400	COG0612	Peptidase, M16
CGC53_RS00405	COG0612	Peptidase, M16
CGC53_RS00410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CGC53_RS00415	COG0167	dihydroorotate dehydrogenase activity
CGC53_RS00435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CGC53_RS00440	COG1120	ATPase activity
CGC53_RS00445	COG1648	precorrin-2 dehydrogenase activity
CGC53_RS00445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CGC53_RS00470	COG0315	cyclic pyranopterin monophosphate synthase activity
CGC53_RS00470	COG0521	Mo-molybdopterin cofactor biosynthetic process
CGC53_RS00475	COG0314	molybdopterin synthase activity
CGC53_RS00485	COG1193	negative regulation of DNA recombination
CGC53_RS00500	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CGC53_RS00505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CGC53_RS00515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CGC53_RS00520	COG3340	Belongs to the peptidase S51 family
CGC53_RS00525	COG2017	converts alpha-aldose to the beta-anomer
CGC53_RS00530	COG2356	endonuclease I
CGC53_RS00535	COG0514	ATP-dependent DNA helicase (RecQ)
CGC53_RS00540	COG0542	response to heat
CGC53_RS00545	COG0791	NLP P60 protein
CGC53_RS00550	COG2333	competence protein COMEC
CGC53_RS00550	COG0658	competence protein
CGC53_RS00570	COG0022	dehydrogenase e1 component
CGC53_RS00575	COG0179	Fumarylacetoacetate (FAA) hydrolase
CGC53_RS00585	COG0191	fructose-bisphosphate aldolase activity
CGC53_RS00590	COG0280	phosphate acetyltransferase
CGC53_RS00590	COG0857	belongs to the CobB CobQ family
CGC53_RS00595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CGC53_RS00600	COG1166	arginine decarboxylase activity
CGC53_RS00640	COG1404	Belongs to the peptidase S8 family
CGC53_RS00675	COG3591	Belongs to the peptidase S1B family
CGC53_RS00685	COG0012	GTP binding
CGC53_RS00690	COG3594	Acyltransferase
CGC53_RS00705	COG1132	(ABC) transporter
CGC53_RS00735	COG0588	phosphoglycerate mutase activity
CGC53_RS00740	COG0438	transferase activity, transferring glycosyl groups
CGC53_RS00760	COG0243	molybdopterin cofactor binding
CGC53_RS00765	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CGC53_RS00795	COG3842	ATPase activity
CGC53_RS00820	COG1999	signal sequence binding
CGC53_RS00825	COG0303	'Molybdopterin
CGC53_RS00835	COG0746	molybdenum cofactor guanylyltransferase activity
CGC53_RS00840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CGC53_RS00845	COG0302	gtp cyclohydrolase
CGC53_RS00850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CGC53_RS00855	COG1304	FMN binding
CGC53_RS00860	COG2183	response to ionizing radiation
CGC53_RS00865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CGC53_RS00880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CGC53_RS00890	COG0737	Belongs to the 5'-nucleotidase family
CGC53_RS00895	COG0737	Belongs to the 5'-nucleotidase family
CGC53_RS00905	COG1538	Outer membrane efflux protein
CGC53_RS00910	COG1309	transcriptional regulator
CGC53_RS00925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CGC53_RS00930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CGC53_RS00935	COG4771	TonB-dependent receptor
CGC53_RS00955	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CGC53_RS00960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CGC53_RS00965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CGC53_RS00970	COG2814	Major facilitator Superfamily
CGC53_RS00980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CGC53_RS00985	COG4452	Inner membrane protein CreD
CGC53_RS01015	COG0427	acetyl-CoA hydrolase
CGC53_RS01020	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CGC53_RS01025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CGC53_RS01030	COG0626	cystathionine gamma-synthase activity
CGC53_RS01035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CGC53_RS01045	COG1393	Belongs to the ArsC family
CGC53_RS01050	COG1349	DNA-binding transcription factor activity
CGC53_RS01060	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CGC53_RS01080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CGC53_RS01085	COG1215	transferase activity, transferring glycosyl groups
CGC53_RS01100	COG1696	Membrane protein involved in D-alanine export
CGC53_RS01125	COG3757	hydrolase, family 25
CGC53_RS01130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CGC53_RS01140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CGC53_RS01145	COG0138	bifunctional purine biosynthesis protein purh
CGC53_RS01165	COG2268	Band 7 protein
CGC53_RS01180	COG1045	serine acetyltransferase
CGC53_RS01185	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CGC53_RS01185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CGC53_RS01195	COG0792	nuclease activity
CGC53_RS01200	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CGC53_RS01220	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CGC53_RS01220	COG0662	Cupin 2, conserved barrel domain protein
CGC53_RS01245	COG1395	domain, Protein
CGC53_RS01415	COG4974	Belongs to the 'phage' integrase family
CGC53_RS01425	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CGC53_RS01430	COG0215	cysteine-tRNA ligase activity
CGC53_RS01440	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CGC53_RS01450	COG0606	chelatase, subunit chli
CGC53_RS01470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CGC53_RS01475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CGC53_RS01505	COG0326	Molecular chaperone. Has ATPase activity
CGC53_RS01510	COG2824	Alkylphosphonate utilization operon protein PhnA
CGC53_RS01525	COG1523	belongs to the glycosyl hydrolase 13 family
CGC53_RS01550	COG0339	signal peptide processing
CGC53_RS01560	COG0786	glutamate:sodium symporter activity
CGC53_RS01565	COG0285	dihydrofolate synthase activity
CGC53_RS01580	COG0811	peptide transport
CGC53_RS01600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CGC53_RS01605	COG2502	aspartate--ammonia ligase
CGC53_RS01615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CGC53_RS01620	COG3590	peptidase
CGC53_RS01625	COG0562	UDP-galactopyranose mutase
CGC53_RS01630	COG5434	Belongs to the glycosyl hydrolase 28 family
CGC53_RS01640	COG2264	protein methyltransferase activity
CGC53_RS01670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CGC53_RS01685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CGC53_RS01690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CGC53_RS01705	COG0492	ferredoxin-NADP+ reductase activity
CGC53_RS01720	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CGC53_RS01755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CGC53_RS01770	COG0726	polysaccharide deacetylase
CGC53_RS01785	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CGC53_RS01810	COG0826	peptidase U32
CGC53_RS01815	COG3876	Protein conserved in bacteria
CGC53_RS01830	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CGC53_RS01835	COG0542	response to heat
CGC53_RS01840	COG0443	Heat shock 70 kDa protein
CGC53_RS01845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CGC53_RS01850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CGC53_RS01860	COG0552	protein localization to endoplasmic reticulum
CGC53_RS01880	COG1805	sodium ion transport
CGC53_RS01885	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CGC53_RS01890	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CGC53_RS01895	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CGC53_RS01910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CGC53_RS01915	COG3119	arylsulfatase activity
CGC53_RS01920	COG3250	beta-galactosidase activity
CGC53_RS01930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CGC53_RS01935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CGC53_RS01950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CGC53_RS01955	COG1477	protein flavinylation
CGC53_RS01960	COG1477	protein flavinylation
CGC53_RS01965	COG2226	methyltransferase
CGC53_RS01970	COG0671	phosphoesterase, PA-phosphatase related
CGC53_RS01975	COG1968	undecaprenyl-diphosphatase activity
CGC53_RS01985	COG2177	Part of the ABC transporter FtsEX involved in
CGC53_RS01995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CGC53_RS02000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CGC53_RS02020	COG0772	Belongs to the SEDS family
CGC53_RS02030	COG2321	neutral zinc metallopeptidase
CGC53_RS02035	COG0321	lipoyl(octanoyl) transferase activity
CGC53_RS02040	COG0563	adenylate kinase activity
CGC53_RS02085	COG1012	belongs to the aldehyde dehydrogenase family
CGC53_RS02090	COG2985	domain, Protein
CGC53_RS02090	COG0569	domain protein
CGC53_RS02095	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CGC53_RS02100	COG1192	Involved in chromosome partitioning
CGC53_RS02105	COG1475	DNA binding
CGC53_RS02115	COG0277	FAD linked oxidase domain protein
CGC53_RS02140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CGC53_RS02155	COG0196	riboflavin kinase activity
CGC53_RS02160	COG1022	Amp-dependent synthetase and ligase
CGC53_RS02165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CGC53_RS02170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CGC53_RS02175	COG1181	Belongs to the D-alanine--D-alanine ligase family
CGC53_RS02190	COG1160	GTP binding
CGC53_RS02200	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CGC53_RS02205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CGC53_RS02210	COG0860	N-Acetylmuramoyl-L-alanine amidase
CGC53_RS02215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CGC53_RS02220	COG0247	lactate metabolic process
CGC53_RS02220	COG2181	nitrate reductase activity
CGC53_RS02235	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CGC53_RS02240	COG0018	arginyl-trna synthetase
CGC53_RS02260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CGC53_RS02265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CGC53_RS02290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CGC53_RS02300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CGC53_RS02310	COG0019	diaminopimelate decarboxylase activity
CGC53_RS02330	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CGC53_RS02340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CGC53_RS02350	COG4771	TonB-dependent receptor
CGC53_RS02370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CGC53_RS02375	COG0799	negative regulation of ribosome biogenesis
CGC53_RS02385	COG0590	tRNA wobble adenosine to inosine editing
CGC53_RS02395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CGC53_RS02400	COG2884	Cell division ATP-binding protein ftsE
CGC53_RS02410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CGC53_RS02415	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CGC53_RS02420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CGC53_RS02420	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CGC53_RS02425	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CGC53_RS02430	COG1078	dGTPase activity
CGC53_RS02435	COG1368	sulfuric ester hydrolase activity
CGC53_RS02440	COG0592	DNA-directed DNA polymerase activity
CGC53_RS02450	COG1132	(ABC) transporter
CGC53_RS02460	COG1522	sequence-specific DNA binding
CGC53_RS02465	COG1428	Deoxynucleoside kinase
CGC53_RS02480	COG0205	6-phosphofructokinase activity
CGC53_RS02490	COG2195	Cleaves the N-terminal amino acid of tripeptides
CGC53_RS02495	COG1137	ATPase activity
CGC53_RS02505	COG0805	protein transport
CGC53_RS02525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CGC53_RS02535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CGC53_RS02540	COG4589	Belongs to the CDS family
CGC53_RS02565	COG0252	asparaginase activity
CGC53_RS02570	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CGC53_RS02580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CGC53_RS02600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CGC53_RS02610	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CGC53_RS02635	COG0268	Binds directly to 16S ribosomal RNA
CGC53_RS02650	COG0508	dehydrogenase complex catalyzes the overall conversion of
CGC53_RS02655	COG1629	transport
CGC53_RS02660	COG0567	Dehydrogenase, E1 component
CGC53_RS02670	COG0242	peptide deformylase activity
CGC53_RS02680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CGC53_RS02710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CGC53_RS02735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CGC53_RS02740	COG1621	beta-fructofuranosidase activity
CGC53_RS02750	COG2837	iron assimilation
CGC53_RS02755	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CGC53_RS02770	COG0714	Associated with various cellular activities
CGC53_RS02775	COG0673	inositol 2-dehydrogenase activity
CGC53_RS02795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CGC53_RS02805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CGC53_RS02840	COG2351	hydroxyisourate hydrolase activity
CGC53_RS02845	COG0463	Glycosyl transferase, family 2
CGC53_RS02855	COG0386	Belongs to the glutathione peroxidase family
CGC53_RS02880	COG1053	succinate dehydrogenase
CGC53_RS02900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CGC53_RS02925	COG0811	peptide transport
CGC53_RS02935	COG0252	asparaginase activity
CGC53_RS02945	COG0084	hydrolase, TatD family'
CGC53_RS02950	COG0702	epimerase
CGC53_RS02955	COG4206	TonB-dependent receptor
CGC53_RS02955	COG1629	transport
CGC53_RS02960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CGC53_RS02995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CGC53_RS03010	COG0187	DNA topoisomerase II activity
CGC53_RS03015	COG1271	oxidase subunit
CGC53_RS03020	COG1294	oxidase, subunit
CGC53_RS03035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CGC53_RS03040	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CGC53_RS03060	COG1774	PSP1 C-terminal conserved region
CGC53_RS03070	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CGC53_RS03095	COG3275	phosphorelay sensor kinase activity
CGC53_RS03100	COG1136	(ABC) transporter
CGC53_RS03100	COG0577	efflux transmembrane transporter activity
CGC53_RS03135	COG2267	carboxylic ester hydrolase activity
CGC53_RS03145	COG1136	(ABC) transporter
CGC53_RS03150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CGC53_RS03160	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CGC53_RS03165	COG1674	ftsk spoiiie
CGC53_RS03185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CGC53_RS03190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CGC53_RS03200	COG1136	(ABC) transporter
CGC53_RS03225	COG0488	(ABC) transporter
CGC53_RS03235	COG1696	Membrane protein involved in D-alanine export
CGC53_RS03240	COG0017	Asparaginyl-tRNA synthetase
CGC53_RS03265	COG0512	Glutamine amidotransferase of anthranilate synthase
CGC53_RS03265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CGC53_RS03280	COG0134	indole-3-glycerol-phosphate synthase activity
CGC53_RS03285	COG0135	phosphoribosylanthranilate isomerase activity
CGC53_RS03290	COG0133	tryptophan synthase activity
CGC53_RS03310	COG0602	queuosine metabolic process
CGC53_RS03325	COG0180	Tryptophanyl-tRNA synthetase
CGC53_RS03335	COG0339	signal peptide processing
CGC53_RS03415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CGC53_RS03420	COG0322	excinuclease ABC activity
CGC53_RS03470	COG3119	arylsulfatase activity
CGC53_RS03525	COG3104	oligopeptide transport
CGC53_RS03530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CGC53_RS03530	COG0758	DNA mediated transformation
CGC53_RS03535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CGC53_RS03555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CGC53_RS03580	COG0571	ribonuclease III activity
CGC53_RS03585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CGC53_RS03590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CGC53_RS03610	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CGC53_RS03615	COG0456	acetyltransferase
CGC53_RS03615	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CGC53_RS03620	COG0460	homoserine dehydrogenase
CGC53_RS03620	COG0527	aspartate kinase activity
CGC53_RS03625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CGC53_RS03630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CGC53_RS03645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CGC53_RS03670	COG2171	N-acyltransferase activity
CGC53_RS03675	COG0525	valine-tRNA ligase activity
CGC53_RS03680	COG2954	triphosphatase activity
CGC53_RS03690	COG0420	3'-5' exonuclease activity
CGC53_RS03695	COG0116	Belongs to the methyltransferase superfamily
CGC53_RS03695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CGC53_RS03700	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CGC53_RS03710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CGC53_RS03715	COG0772	Belongs to the SEDS family
CGC53_RS03720	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CGC53_RS03725	COG1981	membrane
CGC53_RS03730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CGC53_RS03740	COG1435	thymidine kinase activity
CGC53_RS03750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CGC53_RS03755	COG1012	belongs to the aldehyde dehydrogenase family
CGC53_RS03765	COG3279	Response regulator of the LytR AlgR family
CGC53_RS03775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CGC53_RS03780	COG2251	uridine kinase activity
CGC53_RS03780	COG0195	Participates in both transcription termination and antitermination
CGC53_RS03785	COG0779	Required for maturation of 30S ribosomal subunits
CGC53_RS03815	COG0308	aminopeptidase N
CGC53_RS03820	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CGC53_RS03840	COG0396	ATPase activity
CGC53_RS03850	COG0719	Fe-S assembly protein
CGC53_RS03870	COG4221	oxidoreductase activity
CGC53_RS03880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CGC53_RS03890	COG0616	signal peptide processing
CGC53_RS03895	COG0175	sulfate reduction
CGC53_RS03930	COG0470	DNA polymerase III
CGC53_RS03935	COG0861	Integral membrane protein TerC family
CGC53_RS03960	COG4206	TonB-dependent receptor
CGC53_RS03960	COG1629	transport
CGC53_RS03970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CGC53_RS04010	COG0237	dephospho-CoA kinase activity
CGC53_RS04035	COG1610	YqeY-like protein
CGC53_RS04060	COG2010	Cytochrome c
CGC53_RS04070	COG0437	4 iron, 4 sulfur cluster binding
CGC53_RS04110	COG0423	glycine-tRNA ligase activity
CGC53_RS04185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CGC53_RS04195	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CGC53_RS04210	COG5000	phosphorelay sensor kinase activity
CGC53_RS04225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CGC53_RS04230	COG0203	ribosomal protein L17
CGC53_RS04235	COG0202	RNA polymerase activity
CGC53_RS04240	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CGC53_RS04245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CGC53_RS04250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CGC53_RS04255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CGC53_RS04260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CGC53_RS04265	COG0201	protein transport
CGC53_RS04270	COG0200	Binds to the 23S rRNA
CGC53_RS04275	COG1841	ribosomal large subunit assembly
CGC53_RS04280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CGC53_RS04285	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CGC53_RS04290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CGC53_RS04295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CGC53_RS04300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CGC53_RS04305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CGC53_RS04310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CGC53_RS04315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CGC53_RS04320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CGC53_RS04325	COG0255	Belongs to the universal ribosomal protein uL29 family
CGC53_RS04330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CGC53_RS04335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CGC53_RS04340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CGC53_RS04345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CGC53_RS04350	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CGC53_RS04360	COG0088	Forms part of the polypeptide exit tunnel
CGC53_RS04365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CGC53_RS04370	COG0051	transcription antitermination factor activity, RNA binding
CGC53_RS04375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CGC53_RS04380	COG0049	tRNA binding
CGC53_RS04385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CGC53_RS04405	COG0288	reversible hydration of carbon dioxide
CGC53_RS04445	COG2814	Major facilitator Superfamily
CGC53_RS04455	COG0247	lactate metabolic process
CGC53_RS04455	COG2181	nitrate reductase activity
CGC53_RS04480	COG3340	Belongs to the peptidase S51 family
CGC53_RS04485	COG3340	Belongs to the peptidase S51 family
CGC53_RS04490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CGC53_RS04495	COG0300	oxidoreductase activity
CGC53_RS04520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CGC53_RS04530	COG0450	alkyl hydroperoxide reductase
CGC53_RS04535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CGC53_RS04545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CGC53_RS04550	COG0242	peptide deformylase activity
CGC53_RS04555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CGC53_RS04555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CGC53_RS04580	COG4974	Belongs to the 'phage' integrase family
CGC53_RS04600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CGC53_RS04645	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CGC53_RS04650	COG1575	Belongs to the MenA family. Type 1 subfamily
CGC53_RS04670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CGC53_RS04675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CGC53_RS04680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CGC53_RS04700	COG0756	dUTP diphosphatase activity
CGC53_RS04715	COG3645	SOS response
CGC53_RS04720	COG3189	MarR family transcriptional regulator
CGC53_RS04725	COG0366	Alpha amylase catalytic
CGC53_RS04735	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CGC53_RS04740	COG1629	transport
CGC53_RS04740	COG4206	TonB-dependent receptor
CGC53_RS04745	COG1082	Xylose isomerase domain protein TIM barrel
CGC53_RS04755	COG0028	Belongs to the TPP enzyme family
CGC53_RS04760	COG0438	transferase activity, transferring glycosyl groups
CGC53_RS04800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CGC53_RS04805	COG0673	inositol 2-dehydrogenase activity
CGC53_RS04810	COG1234	tRNA 3'-trailer cleavage
CGC53_RS04820	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CGC53_RS04830	COG1959	2 iron, 2 sulfur cluster binding
CGC53_RS04835	COG1960	acyl-CoA dehydrogenase activity
CGC53_RS04845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CGC53_RS04860	COG3250	beta-galactosidase activity
CGC53_RS04870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CGC53_RS04915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CGC53_RS04930	COG3104	oligopeptide transport
CGC53_RS04935	COG0823	Involved in the tonB-independent uptake of proteins
CGC53_RS04935	COG1506	peptidase
CGC53_RS04940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CGC53_RS04950	COG2966	Psort location CytoplasmicMembrane, score
CGC53_RS04955	COG3537	Alpha-1,2-mannosidase
CGC53_RS04960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CGC53_RS04960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CGC53_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
CGC53_RS04980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CGC53_RS04980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CGC53_RS05005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CGC53_RS05005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CGC53_RS05030	COG4771	TonB-dependent receptor
CGC53_RS05035	COG0702	epimerase
CGC53_RS05040	COG0584	glycerophosphoryl diester phosphodiesterase
CGC53_RS05085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CGC53_RS05090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CGC53_RS05100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CGC53_RS05115	COG0489	protein tyrosine kinase activity
CGC53_RS05120	COG1854	S-ribosylhomocysteine lyase activity
CGC53_RS05125	COG0006	proline dipeptidase activity
CGC53_RS05165	COG0501	Belongs to the peptidase M48B family
CGC53_RS05170	COG1704	LemA family
CGC53_RS05180	COG1091	dTDP-4-dehydrorhamnose reductase activity
CGC53_RS05215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CGC53_RS05250	COG1690	Belongs to the RtcB family
CGC53_RS05255	COG0358	DNA primase activity
CGC53_RS05285	COG2003	Belongs to the UPF0758 family
CGC53_RS05295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CGC53_RS05300	COG0151	Belongs to the GarS family
CGC53_RS05305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CGC53_RS05315	COG0123	including yeast histone deacetylase and acetoin utilization protein
CGC53_RS05325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CGC53_RS05325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CGC53_RS05350	COG2137	regulation of response to DNA damage stimulus
CGC53_RS05385	COG3250	beta-galactosidase activity
CGC53_RS05400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CGC53_RS05410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CGC53_RS05415	COG0563	adenylate kinase activity
CGC53_RS05445	COG4206	TonB-dependent receptor
CGC53_RS05445	COG1629	transport
CGC53_RS05455	COG1629	transport
CGC53_RS05475	COG1027	Aspartate ammonia-lyase
CGC53_RS05490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CGC53_RS05495	COG0393	Putative heavy-metal-binding
CGC53_RS05505	COG0629	single-stranded DNA binding
CGC53_RS05515	COG2066	Belongs to the glutaminase family
CGC53_RS05520	COG2166	iron-sulfur cluster assembly
CGC53_RS05525	COG2151	metal-sulfur cluster biosynthetic enzyme
CGC53_RS05545	COG0438	transferase activity, transferring glycosyl groups
CGC53_RS05560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CGC53_RS05565	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CGC53_RS05600	COG1216	Glycosyl transferase, family 2
CGC53_RS05610	COG0463	Glycosyl transferase, family 2
CGC53_RS05630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CGC53_RS05635	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CGC53_RS05640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CGC53_RS05645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CGC53_RS05675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CGC53_RS05680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CGC53_RS05685	COG0668	transmembrane transport
CGC53_RS05695	COG3878	Protein conserved in bacteria
CGC53_RS05705	COG1082	Xylose isomerase domain protein TIM barrel
CGC53_RS05720	COG0702	epimerase
CGC53_RS05725	COG4771	TonB-dependent receptor
CGC53_RS05800	COG0495	leucyl-tRNA aminoacylation
CGC53_RS05835	COG0557	exoribonuclease II activity
CGC53_RS05845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CGC53_RS05890	COG0778	Nitroreductase
CGC53_RS05910	COG4771	TonB-dependent receptor
CGC53_RS05930	COG0450	alkyl hydroperoxide reductase
CGC53_RS05950	COG0698	ribose 5-phosphate isomerase
CGC53_RS05955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CGC53_RS05970	COG0166	Belongs to the GPI family
CGC53_RS05980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CGC53_RS05985	COG3384	dioxygenase
CGC53_RS05995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CGC53_RS06005	COG1505	serine-type exopeptidase activity
CGC53_RS06010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CGC53_RS06035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CGC53_RS06045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CGC53_RS06050	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CGC53_RS06055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CGC53_RS06065	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CGC53_RS06105	COG4771	TonB-dependent receptor
CGC53_RS06110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CGC53_RS06130	COG0022	dehydrogenase e1 component
CGC53_RS06130	COG0508	dehydrogenase complex catalyzes the overall conversion of
CGC53_RS06140	COG4771	TonB-dependent receptor
CGC53_RS06150	COG2194	sulfuric ester hydrolase activity
CGC53_RS06225	COG3209	COG3209 Rhs family protein
CGC53_RS06265	COG1519	Transferase
CGC53_RS06265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CGC53_RS06285	COG0306	phosphate transporter
CGC53_RS06290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CGC53_RS06295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CGC53_RS06300	COG0823	Involved in the tonB-independent uptake of proteins
CGC53_RS06300	COG1506	peptidase
CGC53_RS06325	COG0562	UDP-galactopyranose mutase
CGC53_RS06335	COG2244	polysaccharide biosynthetic process
CGC53_RS06340	COG0463	Glycosyl transferase, family 2
CGC53_RS06360	COG1215	transferase activity, transferring glycosyl groups
CGC53_RS06405	COG0175	sulfate reduction
CGC53_RS06425	COG1620	l-lactate permease
CGC53_RS06430	COG1702	phosphate starvation-inducible protein PhoH
CGC53_RS06435	COG0516	GMP reductase activity
CGC53_RS06435	COG0517	IMP dehydrogenase activity
CGC53_RS06515	COG1629	transport
CGC53_RS06520	COG0594	ribonuclease P activity
CGC53_RS06525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CGC53_RS06545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CGC53_RS06550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CGC53_RS06555	COG0052	Belongs to the universal ribosomal protein uS2 family
CGC53_RS06560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CGC53_RS06625	COG0037	tRNA processing
CGC53_RS06715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CGC53_RS06720	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CGC53_RS06730	COG3588	fructose-bisphosphate aldolase
CGC53_RS06745	COG0193	aminoacyl-tRNA hydrolase activity
CGC53_RS06755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CGC53_RS06795	COG2373	Large extracellular alpha-helical protein
CGC53_RS06810	COG0596	Alpha beta hydrolase
CGC53_RS06815	COG1950	PFAM Membrane protein of
CGC53_RS06825	COG0564	pseudouridine synthase activity
CGC53_RS06830	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CGC53_RS06870	COG3005	denitrification pathway
CGC53_RS06875	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CGC53_RS06885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CGC53_RS06895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CGC53_RS06900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CGC53_RS06955	COG1629	transport
CGC53_RS06955	COG4206	TonB-dependent receptor
CGC53_RS06960	COG0702	epimerase
CGC53_RS06965	COG0471	metal ion transport
CGC53_RS06975	COG1418	mRNA catabolic process
CGC53_RS07015	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CGC53_RS07020	COG4804	nuclease activity
CGC53_RS07030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CGC53_RS07035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CGC53_RS07060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CGC53_RS07065	COG0750	zinc metalloprotease
CGC53_RS07070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CGC53_RS07075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CGC53_RS07100	COG0463	Glycosyl transferase, family 2
CGC53_RS07140	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CGC53_RS07170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CGC53_RS07205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CGC53_RS07235	COG0445	tRNA wobble uridine modification
CGC53_RS07250	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CGC53_RS07290	COG4771	TonB-dependent receptor
CGC53_RS07315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CGC53_RS07330	COG0469	pyruvate kinase activity
CGC53_RS07340	COG1114	Component of the transport system for branched-chain amino acids
CGC53_RS07430	COG0113	porphobilinogen synthase activity
CGC53_RS07440	COG0126	phosphoglycerate kinase activity
CGC53_RS07450	COG3059	membrane
CGC53_RS07460	COG1253	flavin adenine dinucleotide binding
CGC53_RS07465	COG2353	YceI-like domain
CGC53_RS07475	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CGC53_RS07480	COG3530	Putative quorum-sensing-regulated virulence factor
CGC53_RS07485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CGC53_RS07500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CGC53_RS07515	COG1077	Cell shape determining protein MreB Mrl
CGC53_RS07520	COG1792	Involved in formation and maintenance of cell shape
CGC53_RS07545	COG0424	maF-like protein
CGC53_RS07560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CGC53_RS07565	COG0556	nucleotide-excision repair
CGC53_RS07595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CGC53_RS07600	COG2986	histidine ammonia-lyase
CGC53_RS07605	COG2706	6-phosphogluconolactonase activity
CGC53_RS07610	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CGC53_RS07620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CGC53_RS07660	COG1490	D-aminoacyl-tRNA deacylase activity
CGC53_RS07705	COG0259	pyridoxamine-phosphate oxidase activity
CGC53_RS07710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CGC53_RS07730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CGC53_RS07735	COG0081	regulation of translation
CGC53_RS07740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CGC53_RS07745	COG0222	ribosome binding
CGC53_RS07765	COG0085	RNA polymerase activity
CGC53_RS07770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CGC53_RS07785	COG0653	protein targeting
CGC53_RS07800	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CGC53_RS07805	COG1611	Belongs to the LOG family
CGC53_RS07810	COG4717	serine-type aminopeptidase activity
CGC53_RS07815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CGC53_RS07820	COG0708	Exodeoxyribonuclease III
CGC53_RS07825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CGC53_RS07830	COG1482	cell wall glycoprotein biosynthetic process
CGC53_RS07840	COG4974	Belongs to the 'phage' integrase family
CGC53_RS07850	COG0732	type I restriction modification DNA specificity domain
CGC53_RS07870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CGC53_RS07875	COG0484	heat shock protein binding
CGC53_RS07880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CGC53_RS07890	COG1629	transport
CGC53_RS07890	COG4206	TonB-dependent receptor
CGC53_RS07895	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CGC53_RS07905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CGC53_RS07940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CGC53_RS07960	COG0671	phosphoesterase, PA-phosphatase related
CGC53_RS07990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CGC53_RS08005	COG2204	response regulator
CGC53_RS08020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CGC53_RS08025	COG0776	regulation of translation
CGC53_RS08030	COG1530	ribonuclease E activity
CGC53_RS08040	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CGC53_RS08040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CGC53_RS08045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CGC53_RS08050	COG1216	Glycosyl transferase, family 2
CGC53_RS08050	COG0463	Glycosyl transferase, family 2
CGC53_RS08060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CGC53_RS08065	COG0719	Fe-S assembly protein
CGC53_RS08110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CGC53_RS08155	COG1162	GTPase activity
CGC53_RS08170	COG1132	(ABC) transporter
CGC53_RS08195	COG0783	Belongs to the Dps family
CGC53_RS08210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CGC53_RS08220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CGC53_RS08225	COG0124	histidyl-tRNA synthetase
CGC53_RS08230	COG2226	methyltransferase
CGC53_RS08235	COG3956	TIGRFAM MazG family protein
CGC53_RS08245	COG0527	aspartate kinase activity
CGC53_RS08255	COG3022	response to hydroperoxide
CGC53_RS08265	COG4953	penicillin-binding protein 1C
CGC53_RS08270	COG0632	four-way junction helicase activity
CGC53_RS08275	COG0459	protein refolding
CGC53_RS08280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CGC53_RS08305	COG0505	Belongs to the CarA family
CGC53_RS08315	COG0148	phosphopyruvate hydratase activity
CGC53_RS08325	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CGC53_RS08330	COG0321	lipoyl(octanoyl) transferase activity
CGC53_RS08330	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CGC53_RS08355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CGC53_RS08375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CGC53_RS08380	COG0405	Gamma-glutamyltransferase
CGC53_RS08385	COG0045	succinate-CoA ligase (ADP-forming) activity
CGC53_RS08395	COG0366	Alpha amylase catalytic
CGC53_RS08450	COG0540	Belongs to the ATCase OTCase family
CGC53_RS08475	COG4676	Protein conserved in bacteria
CGC53_RS08485	COG0251	oxidation-reduction process
CGC53_RS08490	COG0739	heme binding
CGC53_RS08495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CGC53_RS08530	COG1739	Uncharacterized protein family UPF0029
CGC53_RS08535	COG0673	inositol 2-dehydrogenase activity
CGC53_RS08560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CGC53_RS08565	COG0356	it plays a direct role in the translocation of protons across the membrane
CGC53_RS08570	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CGC53_RS08575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CGC53_RS08580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CGC53_RS08585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CGC53_RS08595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CGC53_RS08600	COG1187	pseudouridine synthase activity
CGC53_RS08605	COG2255	four-way junction helicase activity
CGC53_RS08610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CGC53_RS08615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CGC53_RS08620	COG0511	ligase activity, forming carbon-carbon bonds
CGC53_RS08625	COG0439	Biotin carboxylase
CGC53_RS08630	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CGC53_RS08640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CGC53_RS08645	COG0508	dehydrogenase complex catalyzes the overall conversion of
CGC53_RS08660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CGC53_RS08665	COG0840	transmembrane signaling receptor activity
CGC53_RS08670	COG0840	transmembrane signaling receptor activity
CGC53_RS08680	COG1022	Amp-dependent synthetase and ligase
CGC53_RS08685	COG0564	pseudouridine synthase activity
CGC53_RS08695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CGC53_RS08700	COG1428	Deoxynucleoside kinase
CGC53_RS08705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CGC53_RS08720	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CGC53_RS08730	COG0442	prolyl-tRNA aminoacylation
CGC53_RS08735	COG0793	Belongs to the peptidase S41A family
CGC53_RS08775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CGC53_RS08785	COG1185	polyribonucleotide nucleotidyltransferase activity
CGC53_RS08790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CGC53_RS08795	COG1217	gtp-binding protein TYPA
CGC53_RS08825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CGC53_RS08830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CGC53_RS08845	COG0305	Participates in initiation and elongation during chromosome replication
CGC53_RS08860	COG0509	glycine decarboxylation via glycine cleavage system
CGC53_RS08880	COG0825	malonyl-CoA metabolic process
CGC53_RS08885	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CGC53_RS08900	COG4772	TonB-dependent receptor
CGC53_RS08915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CGC53_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
CGC53_RS08950	COG0297	glycogen (starch) synthase activity
CGC53_RS08955	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CGC53_RS08975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CGC53_RS09000	COG1629	transport
CGC53_RS09005	COG0702	epimerase
CGC53_RS09010	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CGC53_RS09020	COG2885	chlorophyll binding
CGC53_RS09045	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CGC53_RS09075	COG0802	atpase or kinase
CGC53_RS09080	COG4948	Mandelate Racemase Muconate Lactonizing
CGC53_RS09085	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CGC53_RS09085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CGC53_RS09100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CGC53_RS09110	COG0275	rRNA processing
CGC53_RS09125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CGC53_RS09140	COG4771	TonB-dependent receptor
CGC53_RS09150	COG3842	ATPase activity
CGC53_RS09165	COG1528	Iron-storage protein
CGC53_RS09175	COG1663	tetraacyldisaccharide 4'-kinase activity
CGC53_RS09185	COG2204	response regulator
CGC53_RS09190	COG2949	membrane
CGC53_RS09195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CGC53_RS09200	COG2304	oxidoreductase activity
CGC53_RS09210	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CGC53_RS09220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CGC53_RS09235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CGC53_RS09240	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CGC53_RS09245	COG0784	Response regulator, receiver
CGC53_RS09245	COG2205	protein histidine kinase activity
CGC53_RS09250	COG0813	purine-nucleoside phosphorylase activity
CGC53_RS09260	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CGC53_RS09265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CGC53_RS09315	COG0517	IMP dehydrogenase activity
CGC53_RS09315	COG1125	glycine betaine transport
CGC53_RS09340	COG3279	Response regulator of the LytR AlgR family
CGC53_RS09345	COG3275	phosphorelay sensor kinase activity
CGC53_RS09395	COG0463	Glycosyl transferase, family 2
CGC53_RS09400	COG0156	8-amino-7-oxononanoate synthase activity
CGC53_RS09415	COG1715	Restriction endonuclease
CGC53_RS09430	COG2885	chlorophyll binding
CGC53_RS09430	COG3047	cAMP biosynthetic process
CGC53_RS09440	COG4974	Belongs to the 'phage' integrase family
CGC53_RS09445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CGC53_RS09445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CGC53_RS09460	COG1288	antiporter activity
CGC53_RS09470	COG1288	antiporter activity
CGC53_RS09505	COG0481	GTPase activity
CGC53_RS09510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CGC53_RS09515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CGC53_RS09520	COG4771	TonB-dependent receptor
CGC53_RS09525	COG0702	epimerase
CGC53_RS09555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CGC53_RS09560	COG1629	transport
CGC53_RS09570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CGC53_RS09585	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CGC53_RS09625	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CGC53_RS09670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CGC53_RS09690	COG2304	oxidoreductase activity
CGC53_RS09695	COG0254	rRNA binding
CGC53_RS09710	COG1764	response to oxidative stress
CGC53_RS09720	COG0656	L-ascorbic acid biosynthetic process
CGC53_RS09730	COG1917	Cupin 2, conserved barrel domain protein
CGC53_RS09730	COG4977	sequence-specific DNA binding
CGC53_RS09740	COG2197	response regulator
CGC53_RS09805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CGC53_RS09810	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CGC53_RS09820	COG0284	orotidine-5'-phosphate decarboxylase activity
CGC53_RS09830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CGC53_RS09835	COG0776	regulation of translation
CGC53_RS09840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CGC53_RS09845	COG1862	Preprotein translocase
CGC53_RS09860	COG0840	transmembrane signaling receptor activity
CGC53_RS09875	COG0009	L-threonylcarbamoyladenylate synthase
CGC53_RS09880	COG2050	protein possibly involved in aromatic compounds catabolism
CGC53_RS09900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CGC53_RS09910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CGC53_RS09925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CGC53_RS09930	COG0228	four-way junction DNA binding
CGC53_RS09935	COG1136	(ABC) transporter
CGC53_RS09935	COG0577	efflux transmembrane transporter activity
CGC53_RS09945	COG3951	Flagellar rod assembly protein muramidase FlgJ
CGC53_RS09945	COG1705	Flagellar rod assembly protein muramidase FlgJ
CGC53_RS09950	COG2890	protein-(glutamine-N5) methyltransferase activity
CGC53_RS09955	COG0539	negative regulation of cytoplasmic translation
CGC53_RS09960	COG4152	abc transporter atp-binding protein
CGC53_RS09970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CGC53_RS09975	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CGC53_RS09985	COG2733	membrane
CGC53_RS09990	COG0343	queuine tRNA-ribosyltransferase activity
CGC53_RS10000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CGC53_RS10005	COG2239	Acts as a magnesium transporter
CGC53_RS10010	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CGC53_RS10015	COG0233	cytoplasmic translational termination
CGC53_RS10035	COG0528	UMP kinase activity
CGC53_RS10060	COG0714	Associated with various cellular activities
CGC53_RS10085	COG2304	oxidoreductase activity
CGC53_RS10090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CGC53_RS10110	COG3209	COG3209 Rhs family protein
CGC53_RS10110	COG4104	PAAR repeat-containing protein
CGC53_RS10120	COG3209	COG3209 Rhs family protein
CGC53_RS10135	COG1760	l-serine dehydratase
CGC53_RS10140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CGC53_RS10155	COG2843	Capsule synthesis protein
CGC53_RS10165	COG1266	CAAX protease self-immunity
CGC53_RS10170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CGC53_RS10175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CGC53_RS10180	COG0149	triose-phosphate isomerase activity
CGC53_RS10185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CGC53_RS10195	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CGC53_RS10200	COG1629	transport
CGC53_RS10200	COG4206	TonB-dependent receptor
CGC53_RS10215	COG0084	hydrolase, TatD family'
CGC53_RS10235	COG0681	Belongs to the peptidase S26 family
CGC53_RS10240	COG0561	phosphatase activity
CGC53_RS10245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CGC53_RS10255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CGC53_RS10260	COG1295	ribonuclease BN
CGC53_RS10270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CGC53_RS10280	COG0519	Catalyzes the synthesis of GMP from XMP
CGC53_RS10280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CGC53_RS10285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CGC53_RS10290	COG0504	CTP synthase activity
CGC53_RS10295	COG0706	membrane insertase activity
CGC53_RS10300	COG0363	glucosamine-6-phosphate deaminase activity
CGC53_RS10315	COG0688	phosphatidylethanolamine metabolic process
CGC53_RS10325	COG0217	transcriptional regulatory protein
CGC53_RS10330	COG0517	IMP dehydrogenase activity
CGC53_RS10330	COG0516	GMP reductase activity
CGC53_RS10335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CGC53_RS10340	COG0569	domain protein
CGC53_RS10345	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CGC53_RS10350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CGC53_RS10355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CGC53_RS10360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CGC53_RS10375	COG0668	transmembrane transport
CGC53_RS10410	COG0612	Peptidase, M16
CGC53_RS10415	COG0633	Ferredoxin
CGC53_RS10425	COG0492	ferredoxin-NADP+ reductase activity
CGC53_RS10430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CGC53_RS10445	COG0617	tRNA 3'-terminal CCA addition
CGC53_RS10445	COG0517	IMP dehydrogenase activity
CGC53_RS10445	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CGC53_RS10450	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CGC53_RS10455	COG2095	MarC family integral membrane protein
CGC53_RS10460	COG1333	cytochrome c biogenesis protein
CGC53_RS10460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CGC53_RS10485	COG2226	methyltransferase
CGC53_RS10525	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CGC53_RS10530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CGC53_RS10540	COG0488	(ABC) transporter
CGC53_RS10565	COG2885	chlorophyll binding
CGC53_RS10570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CGC53_RS10580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CGC53_RS10605	COG0295	cytidine deaminase activity
CGC53_RS10610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CGC53_RS10615	COG1506	peptidase
CGC53_RS10615	COG0823	Involved in the tonB-independent uptake of proteins
CGC53_RS10630	COG1970	mechanosensitive ion channel activity
CGC53_RS10635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CGC53_RS10640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CGC53_RS10645	COG3341	Caulimovirus viroplasmin
CGC53_RS10645	COG0328	RNA-DNA hybrid ribonuclease activity
CGC53_RS10650	COG0488	(ABC) transporter
CGC53_RS10695	COG1131	(ABC) transporter
CGC53_RS10705	COG1131	(ABC) transporter
CGC53_RS10710	COG0842	Transport permease protein
CGC53_RS10715	COG0842	Transport permease protein
CGC53_RS10725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CGC53_RS10745	COG0544	peptidyl-prolyl cis-trans isomerase activity
CGC53_RS10750	COG0740	serine-type endopeptidase activity
CGC53_RS10755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CGC53_RS10770	COG0336	Belongs to the RNA methyltransferase TrmD family
CGC53_RS10775	COG0318	PFAM AMP-dependent synthetase and ligase
CGC53_RS10790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CGC53_RS10815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CGC53_RS10820	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CGC53_RS10840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CGC53_RS10850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CGC53_RS10855	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CGC53_RS10875	COG1252	NADH dehydrogenase
CGC53_RS10890	COG1752	Esterase of the alpha-beta hydrolase superfamily
CGC53_RS10895	COG2195	Cleaves the N-terminal amino acid of tripeptides
CGC53_RS10915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CGC53_RS10930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CGC53_RS10945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CGC53_RS10950	COG0628	permease
CGC53_RS10960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CGC53_RS10965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CGC53_RS10970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CGC53_RS10985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CGC53_RS11005	COG1346	cytolysis
CGC53_RS11035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CGC53_RS11050	COG1335	isochorismatase
CGC53_RS11060	COG2223	nitrite transmembrane transporter activity
CGC53_RS11065	COG0010	Belongs to the arginase family
CGC53_RS11070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CGC53_RS11095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CGC53_RS11100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CGC53_RS11100	COG0116	Belongs to the methyltransferase superfamily
CGC53_RS11110	COG2226	methyltransferase
CGC53_RS11130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CGC53_RS11140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CGC53_RS11150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CGC53_RS11155	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CGC53_RS11160	COG0471	metal ion transport
CGC53_RS11160	COG0490	domain, Protein
CGC53_RS11170	COG1104	cysteine desulfurase activity
CGC53_RS11180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CGC53_RS11185	COG1136	(ABC) transporter
CGC53_RS11190	COG1216	Glycosyl transferase, family 2
CGC53_RS11195	COG0335	large ribosomal subunit rRNA binding
CGC53_RS11200	COG2176	DNA-directed DNA polymerase activity
CGC53_RS11210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CGC53_RS11215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CGC53_RS11225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CGC53_RS11225	COG0517	IMP dehydrogenase activity
CGC53_RS11235	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CGC53_RS11245	COG0824	Thioesterase