locus-tag	class	description
CBG49_RS00020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CBG49_RS00030	COG0626	cystathionine gamma-synthase activity
CBG49_RS00085	COG1162	GTPase activity
CBG49_RS00095	COG1854	S-ribosylhomocysteine lyase activity
CBG49_RS00105	COG0006	proline dipeptidase activity
CBG49_RS00145	COG4774	siderophore transport
CBG49_RS00180	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CBG49_RS00185	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CBG49_RS00200	COG0489	protein tyrosine kinase activity
CBG49_RS00265	COG0702	epimerase
CBG49_RS00275	COG4771	TonB-dependent receptor
CBG49_RS00330	COG0702	epimerase
CBG49_RS00335	COG4771	TonB-dependent receptor
CBG49_RS00370	COG3250	beta-galactosidase activity
CBG49_RS00385	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CBG49_RS00390	COG1629	transport
CBG49_RS00390	COG4206	TonB-dependent receptor
CBG49_RS00400	COG1082	Xylose isomerase domain protein TIM barrel
CBG49_RS00410	COG3842	ATPase activity
CBG49_RS00425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CBG49_RS00460	COG1918	ferrous iron import across plasma membrane
CBG49_RS00460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CBG49_RS00485	COG0666	response to abiotic stimulus
CBG49_RS00495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CBG49_RS00510	COG0469	pyruvate kinase activity
CBG49_RS00525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CBG49_RS00555	COG1114	Component of the transport system for branched-chain amino acids
CBG49_RS00570	COG0756	dUTP diphosphatase activity
CBG49_RS00595	COG4152	abc transporter atp-binding protein
CBG49_RS00620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CBG49_RS00660	COG2373	Large extracellular alpha-helical protein
CBG49_RS00705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CBG49_RS00715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CBG49_RS00720	COG0288	reversible hydration of carbon dioxide
CBG49_RS00735	COG0596	Alpha beta hydrolase
CBG49_RS00740	COG2076	Multidrug Resistance protein
CBG49_RS00745	COG0564	pseudouridine synthase activity
CBG49_RS00760	COG1629	transport
CBG49_RS00760	COG4206	TonB-dependent receptor
CBG49_RS00815	COG2194	sulfuric ester hydrolase activity
CBG49_RS00820	COG0300	oxidoreductase activity
CBG49_RS00825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CBG49_RS00835	COG3340	Belongs to the peptidase S51 family
CBG49_RS00840	COG3340	Belongs to the peptidase S51 family
CBG49_RS00845	COG3340	Belongs to the peptidase S51 family
CBG49_RS00915	COG0247	lactate metabolic process
CBG49_RS00915	COG2181	nitrate reductase activity
CBG49_RS00930	COG2814	Major facilitator Superfamily
CBG49_RS00955	COG0563	adenylate kinase activity
CBG49_RS00960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CBG49_RS01025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CBG49_RS01040	COG5000	phosphorelay sensor kinase activity
CBG49_RS01050	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CBG49_RS01070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBG49_RS01085	COG0556	nucleotide-excision repair
CBG49_RS01095	COG0823	Involved in the tonB-independent uptake of proteins
CBG49_RS01095	COG1506	peptidase
CBG49_RS01100	COG3104	oligopeptide transport
CBG49_RS01130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBG49_RS01190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CBG49_RS01195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CBG49_RS01220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CBG49_RS01240	COG1960	acyl-CoA dehydrogenase activity
CBG49_RS01260	COG4206	TonB-dependent receptor
CBG49_RS01260	COG1629	transport
CBG49_RS01265	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CBG49_RS01270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CBG49_RS01300	COG0668	transmembrane transport
CBG49_RS01310	COG2966	Psort location CytoplasmicMembrane, score
CBG49_RS01345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBG49_RS01345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CBG49_RS01370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CBG49_RS01375	COG1575	Belongs to the MenA family. Type 1 subfamily
CBG49_RS01380	COG1214	PFAM Peptidase M22, glycoprotease
CBG49_RS01390	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CBG49_RS01400	COG3588	fructose-bisphosphate aldolase
CBG49_RS01405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CBG49_RS01450	COG3250	beta-galactosidase activity
CBG49_RS01485	COG0438	transferase activity, transferring glycosyl groups
CBG49_RS01705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CBG49_RS01710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CBG49_RS01715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CBG49_RS01720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CBG49_RS01745	COG1472	Belongs to the glycosyl hydrolase 3 family
CBG49_RS01775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CBG49_RS01820	COG0151	Belongs to the GarS family
CBG49_RS01825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CBG49_RS01840	COG2003	Belongs to the UPF0758 family
CBG49_RS01880	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CBG49_RS01900	COG3189	MarR family transcriptional regulator
CBG49_RS01920	COG0358	DNA primase activity
CBG49_RS01935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CBG49_RS01945	COG0393	Putative heavy-metal-binding
CBG49_RS02000	COG0629	single-stranded DNA binding
CBG49_RS02060	COG4771	TonB-dependent receptor
CBG49_RS02080	COG2066	Belongs to the glutaminase family
CBG49_RS02105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CBG49_RS02120	COG0484	heat shock protein binding
CBG49_RS02140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CBG49_RS02150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CBG49_RS02160	COG4771	TonB-dependent receptor
CBG49_RS02170	COG0584	glycerophosphoryl diester phosphodiesterase
CBG49_RS02175	COG2271	Major facilitator Superfamily
CBG49_RS02210	COG0123	including yeast histone deacetylase and acetoin utilization protein
CBG49_RS02220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CBG49_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
CBG49_RS02260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBG49_RS02285	COG1917	Cupin 2, conserved barrel domain protein
CBG49_RS02285	COG4977	sequence-specific DNA binding
CBG49_RS02300	COG4771	TonB-dependent receptor
CBG49_RS02305	COG0702	epimerase
CBG49_RS02325	COG1082	Xylose isomerase domain protein TIM barrel
CBG49_RS02500	COG0495	leucyl-tRNA aminoacylation
CBG49_RS02515	COG2166	iron-sulfur cluster assembly
CBG49_RS02520	COG2151	metal-sulfur cluster biosynthetic enzyme
CBG49_RS02565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CBG49_RS02585	COG1605	Chorismate mutase
CBG49_RS02585	COG0077	Prephenate dehydratase
CBG49_RS02595	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CBG49_RS02610	COG1690	Belongs to the RtcB family
CBG49_RS02630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CBG49_RS02660	COG1017	nitric oxide dioxygenase activity
CBG49_RS02660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CBG49_RS02760	COG0557	exoribonuclease II activity
CBG49_RS02765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CBG49_RS02860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CBG49_RS02895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CBG49_RS02895	COG1519	Transferase
CBG49_RS02905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CBG49_RS02915	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CBG49_RS02945	COG0105	UTP biosynthetic process
CBG49_RS02980	COG2375	cellular response to nickel ion
CBG49_RS02980	COG1132	(ABC) transporter
CBG49_RS02985	COG1132	(ABC) transporter
CBG49_RS02990	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CBG49_RS02995	COG4771	TonB-dependent receptor
CBG49_RS03000	COG4977	sequence-specific DNA binding
CBG49_RS03015	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CBG49_RS03025	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CBG49_RS03050	COG0022	dehydrogenase e1 component
CBG49_RS03050	COG0508	dehydrogenase complex catalyzes the overall conversion of
CBG49_RS03060	COG4771	TonB-dependent receptor
CBG49_RS03095	COG4974	Belongs to the 'phage' integrase family
CBG49_RS03105	COG0720	synthase
CBG49_RS03125	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CBG49_RS03140	COG0698	ribose 5-phosphate isomerase
CBG49_RS03160	COG1505	serine-type exopeptidase activity
CBG49_RS03165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CBG49_RS03190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CBG49_RS03260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CBG49_RS03270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CBG49_RS03275	COG0306	phosphate transporter
CBG49_RS03300	COG0450	alkyl hydroperoxide reductase
CBG49_RS03305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CBG49_RS03320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CBG49_RS03355	COG0166	Belongs to the GPI family
CBG49_RS03375	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CBG49_RS03450	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CBG49_RS03490	COG4771	TonB-dependent receptor
CBG49_RS03515	COG1620	l-lactate permease
CBG49_RS03530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBG49_RS03535	COG0175	sulfate reduction
CBG49_RS03550	COG0594	ribonuclease P activity
CBG49_RS03555	COG1629	transport
CBG49_RS03615	COG0517	IMP dehydrogenase activity
CBG49_RS03615	COG0516	GMP reductase activity
CBG49_RS03620	COG1702	phosphate starvation-inducible protein PhoH
CBG49_RS03645	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CBG49_RS03650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CBG49_RS03655	COG0052	Belongs to the universal ribosomal protein uS2 family
CBG49_RS03660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CBG49_RS03715	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CBG49_RS03750	COG1506	peptidase
CBG49_RS03750	COG0823	Involved in the tonB-independent uptake of proteins
CBG49_RS03755	COG0193	aminoacyl-tRNA hydrolase activity
CBG49_RS03765	COG1629	transport
CBG49_RS03765	COG4206	TonB-dependent receptor
CBG49_RS03780	COG0702	epimerase
CBG49_RS03805	COG3250	beta-galactosidase activity
CBG49_RS03820	COG3250	beta-galactosidase activity
CBG49_RS03825	COG3292	Two component regulator propeller
CBG49_RS03825	COG2205	protein histidine kinase activity
CBG49_RS03825	COG0745	RESPONSE REGULATOR receiver
CBG49_RS03835	COG0657	acetylesterase activity
CBG49_RS03835	COG2755	lipolytic protein G-D-S-L family
CBG49_RS03845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBG49_RS03875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CBG49_RS03875	COG0543	2 iron, 2 sulfur cluster binding
CBG49_RS03880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CBG49_RS03905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CBG49_RS03930	COG1215	transferase activity, transferring glycosyl groups
CBG49_RS03935	COG1216	Glycosyl transferase, family 2
CBG49_RS03940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CBG49_RS03950	COG1216	Glycosyl transferase, family 2
CBG49_RS03950	COG1442	glycosyl transferase family 8
CBG49_RS03965	COG0438	transferase activity, transferring glycosyl groups
CBG49_RS03995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CBG49_RS04005	COG3047	cAMP biosynthetic process
CBG49_RS04005	COG2885	chlorophyll binding
CBG49_RS04035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CBG49_RS04045	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CBG49_RS04165	COG3005	denitrification pathway
CBG49_RS04170	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CBG49_RS04180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CBG49_RS04240	COG3177	Filamentation induced by cAMP protein fic
CBG49_RS04255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CBG49_RS04260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CBG49_RS04260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CBG49_RS04280	COG1858	cytochrome C peroxidase
CBG49_RS04305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CBG49_RS04305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CBG49_RS04310	COG1234	tRNA 3'-trailer cleavage
CBG49_RS04390	COG0750	zinc metalloprotease
CBG49_RS04400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CBG49_RS04410	COG4206	TonB-dependent receptor
CBG49_RS04410	COG1629	transport
CBG49_RS04415	COG0702	epimerase
CBG49_RS04420	COG0028	Belongs to the TPP enzyme family
CBG49_RS04435	COG0501	Belongs to the peptidase M48B family
CBG49_RS04445	COG1476	TRANSCRIPTIONal
CBG49_RS04540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CBG49_RS04585	COG1418	mRNA catabolic process
CBG49_RS04595	COG0471	metal ion transport
CBG49_RS04635	COG2315	Protein conserved in bacteria
CBG49_RS04675	COG0346	lactoylglutathione lyase activity
CBG49_RS04695	COG5652	VanZ like family
CBG49_RS04740	COG0445	tRNA wobble uridine modification
CBG49_RS04815	COG0113	porphobilinogen synthase activity
CBG49_RS04825	COG0126	phosphoglycerate kinase activity
CBG49_RS04830	COG2207	Transcriptional regulator
CBG49_RS04830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CBG49_RS04835	COG3059	membrane
CBG49_RS04875	COG1981	membrane
CBG49_RS04880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CBG49_RS04890	COG1435	thymidine kinase activity
CBG49_RS04935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CBG49_RS04950	COG0424	maF-like protein
CBG49_RS04980	COG1792	Involved in formation and maintenance of cell shape
CBG49_RS04985	COG1077	Cell shape determining protein MreB Mrl
CBG49_RS05000	COG1082	Xylose isomerase domain protein TIM barrel
CBG49_RS05005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CBG49_RS05030	COG0420	3'-5' exonuclease activity
CBG49_RS05045	COG0116	Belongs to the methyltransferase superfamily
CBG49_RS05045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CBG49_RS05050	COG1012	belongs to the aldehyde dehydrogenase family
CBG49_RS05060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CBG49_RS05065	COG0772	Belongs to the SEDS family
CBG49_RS05075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CBG49_RS05080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CBG49_RS05085	COG3530	Putative quorum-sensing-regulated virulence factor
CBG49_RS05090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CBG49_RS05105	COG0745	RESPONSE REGULATOR receiver
CBG49_RS05110	COG4771	TonB-dependent receptor
CBG49_RS05155	COG0423	glycine-tRNA ligase activity
CBG49_RS05175	COG1610	YqeY-like protein
CBG49_RS05195	COG5557	Pfam Polysulphide reductase, NrfD
CBG49_RS05200	COG0437	4 iron, 4 sulfur cluster binding
CBG49_RS05210	COG0237	dephospho-CoA kinase activity
CBG49_RS05225	COG0287	Prephenate dehydrogenase
CBG49_RS05270	COG1704	LemA family
CBG49_RS05285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CBG49_RS05305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CBG49_RS05315	COG2986	histidine ammonia-lyase
CBG49_RS05320	COG2706	6-phosphogluconolactonase activity
CBG49_RS05355	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CBG49_RS05360	COG2310	stress, protein
CBG49_RS05365	COG3853	Toxic anion resistance protein (TelA)
CBG49_RS05375	COG2310	stress, protein
CBG49_RS05385	COG4245	von Willebrand factor, type A
CBG49_RS05515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CBG49_RS05520	COG0484	heat shock protein binding
CBG49_RS05525	COG0363	glucosamine-6-phosphate deaminase activity
CBG49_RS05540	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CBG49_RS05560	COG1401	restriction endodeoxyribonuclease activity
CBG49_RS05725	COG0259	pyridoxamine-phosphate oxidase activity
CBG49_RS05730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CBG49_RS05750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CBG49_RS05755	COG0081	regulation of translation
CBG49_RS05760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CBG49_RS05765	COG0222	ribosome binding
CBG49_RS05775	COG0085	RNA polymerase activity
CBG49_RS05805	COG3104	oligopeptide transport
CBG49_RS05840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CBG49_RS05845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CBG49_RS05845	COG0758	DNA mediated transformation
CBG49_RS05890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CBG49_RS05895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CBG49_RS05900	COG0571	ribonuclease III activity
CBG49_RS05950	COG2885	chlorophyll binding
CBG49_RS05955	COG0322	excinuclease ABC activity
CBG49_RS05965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CBG49_RS05985	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CBG49_RS06010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CBG49_RS06040	COG0339	signal peptide processing
CBG49_RS06090	COG4771	TonB-dependent receptor
CBG49_RS06095	COG0702	epimerase
CBG49_RS06110	COG1472	Belongs to the glycosyl hydrolase 3 family
CBG49_RS06115	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CBG49_RS06120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CBG49_RS06125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CBG49_RS06130	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CBG49_RS06140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CBG49_RS06155	COG4206	TonB-dependent receptor
CBG49_RS06155	COG1629	transport
CBG49_RS06200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CBG49_RS06250	COG1501	Belongs to the glycosyl hydrolase 31 family
CBG49_RS06255	COG2205	protein histidine kinase activity
CBG49_RS06255	COG3292	Two component regulator propeller
CBG49_RS06255	COG0745	RESPONSE REGULATOR receiver
CBG49_RS06265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CBG49_RS06270	COG1629	transport
CBG49_RS06280	COG0133	tryptophan synthase activity
CBG49_RS06285	COG0135	phosphoribosylanthranilate isomerase activity
CBG49_RS06295	COG0134	indole-3-glycerol-phosphate synthase activity
CBG49_RS06300	COG0512	Glutamine amidotransferase of anthranilate synthase
CBG49_RS06300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CBG49_RS06315	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CBG49_RS06350	COG0719	Fe-S assembly protein
CBG49_RS06355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CBG49_RS06375	COG3022	response to hydroperoxide
CBG49_RS06385	COG0366	Alpha amylase catalytic
CBG49_RS06430	COG0540	Belongs to the ATCase OTCase family
CBG49_RS06435	COG0783	Belongs to the Dps family
CBG49_RS06455	COG0508	dehydrogenase complex catalyzes the overall conversion of
CBG49_RS06465	COG0187	DNA topoisomerase II activity
CBG49_RS06500	COG3118	belongs to the thioredoxin family
CBG49_RS06510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CBG49_RS06515	COG4771	TonB-dependent receptor
CBG49_RS06530	COG0084	hydrolase, TatD family'
CBG49_RS06540	COG0252	asparaginase activity
CBG49_RS06550	COG0811	peptide transport
CBG49_RS06575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CBG49_RS06585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CBG49_RS06605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CBG49_RS06620	COG2351	hydroxyisourate hydrolase activity
CBG49_RS06625	COG0463	Glycosyl transferase, family 2
CBG49_RS06635	COG0386	Belongs to the glutathione peroxidase family
CBG49_RS06660	COG1053	succinate dehydrogenase
CBG49_RS06685	COG0714	Associated with various cellular activities
CBG49_RS06715	COG1074	ATP-dependent DNA helicase activity
CBG49_RS06735	COG2837	iron assimilation
CBG49_RS06740	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CBG49_RS06745	COG2217	Heavy metal translocating P-type atpase
CBG49_RS06775	COG1629	transport
CBG49_RS06780	COG0702	epimerase
CBG49_RS06800	COG1621	beta-fructofuranosidase activity
CBG49_RS06810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CBG49_RS06815	COG0745	RESPONSE REGULATOR receiver
CBG49_RS06815	COG2205	protein histidine kinase activity
CBG49_RS06815	COG3292	Two component regulator propeller
CBG49_RS06915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CBG49_RS06995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CBG49_RS07000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CBG49_RS07010	COG1629	transport
CBG49_RS07040	COG0481	GTPase activity
CBG49_RS07045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CBG49_RS07050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CBG49_RS07055	COG3590	peptidase
CBG49_RS07070	COG2264	protein methyltransferase activity
CBG49_RS07080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CBG49_RS07090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CBG49_RS07095	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CBG49_RS07110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CBG49_RS07140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CBG49_RS07140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CBG49_RS07155	COG0793	Belongs to the peptidase S41A family
CBG49_RS07160	COG0442	prolyl-tRNA aminoacylation
CBG49_RS07185	COG2885	chlorophyll binding
CBG49_RS07210	COG4452	Inner membrane protein CreD
CBG49_RS07220	COG0758	DNA mediated transformation
CBG49_RS07235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CBG49_RS07255	COG0702	epimerase
CBG49_RS07260	COG1629	transport
CBG49_RS07265	COG0277	FAD linked oxidase domain protein
CBG49_RS07275	COG1475	DNA binding
CBG49_RS07280	COG1192	Involved in chromosome partitioning
CBG49_RS07285	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CBG49_RS07295	COG1012	belongs to the aldehyde dehydrogenase family
CBG49_RS07320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CBG49_RS07320	COG1333	cytochrome c biogenesis protein
CBG49_RS07360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CBG49_RS07415	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CBG49_RS07425	COG3119	arylsulfatase activity
CBG49_RS07430	COG3119	arylsulfatase activity
CBG49_RS07445	COG0259	pyridoxamine-phosphate oxidase activity
CBG49_RS07460	COG1490	D-aminoacyl-tRNA deacylase activity
CBG49_RS07465	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CBG49_RS07480	COG0492	ferredoxin-NADP+ reductase activity
CBG49_RS07540	COG0326	Molecular chaperone. Has ATPase activity
CBG49_RS07555	COG2824	Alkylphosphonate utilization operon protein PhnA
CBG49_RS07575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBG49_RS07595	COG0544	peptidyl-prolyl cis-trans isomerase activity
CBG49_RS07605	COG0740	serine-type endopeptidase activity
CBG49_RS07610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CBG49_RS07625	COG0336	Belongs to the RNA methyltransferase TrmD family
CBG49_RS07630	COG0318	PFAM AMP-dependent synthetase and ligase
CBG49_RS07645	COG1252	NADH dehydrogenase
CBG49_RS07655	COG0142	geranyltranstransferase activity
CBG49_RS07660	COG0494	nUDIX hydrolase
CBG49_RS07665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CBG49_RS07670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CBG49_RS07765	COG0018	arginyl-trna synthetase
CBG49_RS07770	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CBG49_RS07805	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CBG49_RS07815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CBG49_RS07830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBG49_RS07845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CBG49_RS07865	COG1131	(ABC) transporter
CBG49_RS07880	COG3292	Two component regulator propeller
CBG49_RS07880	COG0745	RESPONSE REGULATOR receiver
CBG49_RS07880	COG3292	Two component regulator propeller
CBG49_RS07880	COG2205	protein histidine kinase activity
CBG49_RS07880	COG2205	protein histidine kinase activity
CBG49_RS07880	COG0745	RESPONSE REGULATOR receiver
CBG49_RS07885	COG4771	TonB-dependent receptor
CBG49_RS07910	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CBG49_RS07920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CBG49_RS07930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CBG49_RS07935	COG2321	neutral zinc metallopeptidase
CBG49_RS07940	COG0321	lipoyl(octanoyl) transferase activity
CBG49_RS07960	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CBG49_RS07970	COG2814	Major facilitator Superfamily
CBG49_RS07975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CBG49_RS07980	COG0772	Belongs to the SEDS family
CBG49_RS08000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CBG49_RS08010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CBG49_RS08035	COG2226	methyltransferase
CBG49_RS08045	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CBG49_RS08050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CBG49_RS08060	COG0488	(ABC) transporter
CBG49_RS08070	COG2095	MarC family integral membrane protein
CBG49_RS08075	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CBG49_RS08080	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CBG49_RS08080	COG0617	tRNA 3'-terminal CCA addition
CBG49_RS08080	COG0517	IMP dehydrogenase activity
CBG49_RS08085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CBG49_RS08090	COG3594	Acyltransferase
CBG49_RS08100	COG1169	isochorismate synthase
CBG49_RS08105	COG1132	(ABC) transporter
CBG49_RS08110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CBG49_RS08115	COG1295	ribonuclease BN
CBG49_RS08140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CBG49_RS08150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CBG49_RS08150	COG0519	Catalyzes the synthesis of GMP from XMP
CBG49_RS08155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CBG49_RS08160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CBG49_RS08170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CBG49_RS08175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CBG49_RS08195	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CBG49_RS08200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CBG49_RS08205	COG0596	Alpha beta hydrolase
CBG49_RS08210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CBG49_RS08210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CBG49_RS08220	COG0572	uridine kinase
CBG49_RS08225	COG0501	Belongs to the peptidase M48B family
CBG49_RS08235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CBG49_RS08240	COG0528	UMP kinase activity
CBG49_RS08260	COG0233	cytoplasmic translational termination
CBG49_RS08265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CBG49_RS08290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CBG49_RS08300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CBG49_RS08310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CBG49_RS08320	COG0343	queuine tRNA-ribosyltransferase activity
CBG49_RS08325	COG2733	membrane
CBG49_RS08335	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CBG49_RS08340	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CBG49_RS08350	COG4152	abc transporter atp-binding protein
CBG49_RS08380	COG0539	negative regulation of cytoplasmic translation
CBG49_RS08395	COG2217	Heavy metal translocating P-type atpase
CBG49_RS08410	COG0706	membrane insertase activity
CBG49_RS08415	COG0504	CTP synthase activity
CBG49_RS08425	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CBG49_RS08430	COG0824	Thioesterase
CBG49_RS08435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CBG49_RS08440	COG0686	Belongs to the AlaDH PNT family
CBG49_RS08445	COG0514	ATP-dependent DNA helicase (RecQ)
CBG49_RS08475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CBG49_RS08485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CBG49_RS08490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CBG49_RS08495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CBG49_RS08500	COG0194	GDP metabolic process
CBG49_RS08505	COG1561	YicC-like family, N-terminal region
CBG49_RS08510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CBG49_RS08515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CBG49_RS08520	COG0228	four-way junction DNA binding
CBG49_RS08530	COG1193	negative regulation of DNA recombination
CBG49_RS08535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CBG49_RS08540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CBG49_RS08545	COG0149	triose-phosphate isomerase activity
CBG49_RS08550	COG0012	GTP binding
CBG49_RS08555	COG0534	Mate efflux family protein
CBG49_RS08560	COG3591	Belongs to the peptidase S1B family
CBG49_RS08570	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CBG49_RS08595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CBG49_RS08635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CBG49_RS08640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CBG49_RS08645	COG0328	RNA-DNA hybrid ribonuclease activity
CBG49_RS08645	COG3341	Caulimovirus viroplasmin
CBG49_RS08650	COG0488	(ABC) transporter
CBG49_RS08660	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CBG49_RS08675	COG2239	Acts as a magnesium transporter
CBG49_RS08695	COG0811	peptide transport
CBG49_RS08720	COG0022	dehydrogenase e1 component
CBG49_RS08740	COG0658	competence protein
CBG49_RS08740	COG2333	competence protein COMEC
CBG49_RS08745	COG0791	NLP P60 protein
CBG49_RS08750	COG0542	response to heat
CBG49_RS08755	COG0514	ATP-dependent DNA helicase (RecQ)
CBG49_RS08760	COG2356	endonuclease I
CBG49_RS08770	COG0668	transmembrane transport
CBG49_RS08805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CBG49_RS08815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CBG49_RS08820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CBG49_RS08825	COG1304	FMN binding
CBG49_RS08830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CBG49_RS08830	COG0517	IMP dehydrogenase activity
CBG49_RS08835	COG0295	cytidine deaminase activity
CBG49_RS08875	COG1999	signal sequence binding
CBG49_RS08880	COG1217	gtp-binding protein TYPA
CBG49_RS08895	COG1480	7TM receptor with intracellular HD hydrolase
CBG49_RS08900	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CBG49_RS08905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CBG49_RS08910	COG0860	N-Acetylmuramoyl-L-alanine amidase
CBG49_RS08920	COG2181	nitrate reductase activity
CBG49_RS08920	COG0247	lactate metabolic process
CBG49_RS08925	COG2884	Cell division ATP-binding protein ftsE
CBG49_RS08930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CBG49_RS08955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CBG49_RS08960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CBG49_RS08965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBG49_RS09000	COG1215	transferase activity, transferring glycosyl groups
CBG49_RS09005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CBG49_RS09025	COG1408	metallophosphoesterase
CBG49_RS09030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CBG49_RS09040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CBG49_RS09045	COG0612	Peptidase, M16
CBG49_RS09055	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CBG49_RS09065	COG1506	peptidase
CBG49_RS09065	COG0823	Involved in the tonB-independent uptake of proteins
CBG49_RS09080	COG0427	acetyl-CoA hydrolase
CBG49_RS09095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CBG49_RS09100	COG0302	gtp cyclohydrolase
CBG49_RS09115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CBG49_RS09135	COG1522	sequence-specific DNA binding
CBG49_RS09140	COG1401	restriction endodeoxyribonuclease activity
CBG49_RS09170	COG0488	(ABC) transporter
CBG49_RS09200	COG2184	nucleotidyltransferase activity
CBG49_RS09235	COG0471	metal ion transport
CBG49_RS09250	COG1028	Short-chain dehydrogenase reductase Sdr
CBG49_RS09265	COG0598	Magnesium transport protein CorA
CBG49_RS09280	COG0357	Ribosomal RNA small subunit methyltransferase G
CBG49_RS09285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CBG49_RS09295	COG1136	(ABC) transporter
CBG49_RS09300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CBG49_RS09310	COG1104	cysteine desulfurase activity
CBG49_RS09320	COG0490	domain, Protein
CBG49_RS09320	COG0471	metal ion transport
CBG49_RS09325	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CBG49_RS09335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CBG49_RS09335	COG0116	Belongs to the methyltransferase superfamily
CBG49_RS09340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CBG49_RS09350	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CBG49_RS09355	COG0497	DNA recombination
CBG49_RS09365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBG49_RS09365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CBG49_RS09375	COG0433	COG0433 Predicted ATPase
CBG49_RS09385	COG1335	isochorismatase
CBG49_RS09410	COG0436	Aminotransferase
CBG49_RS09415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CBG49_RS09425	COG0010	Belongs to the arginase family
CBG49_RS09435	COG3340	Belongs to the peptidase S51 family
CBG49_RS09445	COG2017	converts alpha-aldose to the beta-anomer
CBG49_RS09500	COG0482	sulfurtransferase activity
CBG49_RS09510	COG0606	chelatase, subunit chli
CBG49_RS09530	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CBG49_RS09535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CBG49_RS09545	COG2195	Cleaves the N-terminal amino acid of tripeptides
CBG49_RS09550	COG1752	Esterase of the alpha-beta hydrolase superfamily
CBG49_RS09565	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CBG49_RS09570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CBG49_RS09580	COG0335	large ribosomal subunit rRNA binding
CBG49_RS09585	COG2176	DNA-directed DNA polymerase activity
CBG49_RS09595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBG49_RS09600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CBG49_RS09615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CBG49_RS09630	COG0668	transmembrane transport
CBG49_RS09635	COG0517	IMP dehydrogenase activity
CBG49_RS09635	COG0516	GMP reductase activity
CBG49_RS09645	COG1393	Belongs to the ArsC family
CBG49_RS09650	COG1349	DNA-binding transcription factor activity
CBG49_RS09660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CBG49_RS09680	COG0492	ferredoxin-NADP+ reductase activity
CBG49_RS09690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CBG49_RS09705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CBG49_RS09720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CBG49_RS09725	COG0191	fructose-bisphosphate aldolase activity
CBG49_RS09740	COG2843	Capsule synthesis protein
CBG49_RS09750	COG1266	CAAX protease self-immunity
CBG49_RS09755	COG0569	domain protein
CBG49_RS09760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CBG49_RS09765	COG0857	belongs to the CobB CobQ family
CBG49_RS09765	COG0280	phosphate acetyltransferase
CBG49_RS09770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CBG49_RS09940	COG0305	Participates in initiation and elongation during chromosome replication
CBG49_RS09995	COG1166	arginine decarboxylase activity
CBG49_RS10000	COG0588	phosphoglycerate mutase activity
CBG49_RS10020	COG0359	binds to the 23S rRNA
CBG49_RS10025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CBG49_RS10030	COG0360	Binds together with S18 to 16S ribosomal RNA
CBG49_RS10050	COG2226	methyltransferase
CBG49_RS10065	COG0438	transferase activity, transferring glycosyl groups
CBG49_RS10090	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CBG49_RS10105	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CBG49_RS10105	COG0662	Cupin 2, conserved barrel domain protein
CBG49_RS10115	COG1538	Outer membrane efflux protein
CBG49_RS10145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CBG49_RS10150	COG0628	permease
CBG49_RS10165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CBG49_RS10170	COG0463	Glycosyl transferase, family 2
CBG49_RS10175	COG0215	cysteine-tRNA ligase activity
CBG49_RS10180	COG0167	dihydroorotate dehydrogenase activity
CBG49_RS10185	COG1970	mechanosensitive ion channel activity
CBG49_RS10190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CBG49_RS10200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CBG49_RS10205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CBG49_RS10225	COG1346	cytolysis
CBG49_RS10230	COG1380	Effector of murein hydrolase LrgA
CBG49_RS10245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CBG49_RS10265	COG1289	transmembrane transporter activity
CBG49_RS10275	COG1381	Involved in DNA repair and RecF pathway recombination
CBG49_RS10280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CBG49_RS10285	COG0508	dehydrogenase complex catalyzes the overall conversion of
CBG49_RS10290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CBG49_RS10295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CBG49_RS10300	COG0714	Associated with various cellular activities
CBG49_RS10320	COG2304	oxidoreductase activity
CBG49_RS10325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CBG49_RS10330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CBG49_RS10335	COG2989	Protein conserved in bacteria
CBG49_RS10340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CBG49_RS10350	COG0737	Belongs to the 5'-nucleotidase family
CBG49_RS10355	COG0737	Belongs to the 5'-nucleotidase family
CBG49_RS10380	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CBG49_RS10390	COG0681	Belongs to the peptidase S26 family
CBG49_RS10395	COG0561	phosphatase activity
CBG49_RS10400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CBG49_RS10410	COG4974	Belongs to the 'phage' integrase family
CBG49_RS10550	COG0758	DNA mediated transformation
CBG49_RS10725	COG3501	Rhs element vgr protein
CBG49_RS10735	COG3501	Rhs element vgr protein
CBG49_RS10745	COG0542	response to heat
CBG49_RS10850	COG1131	(ABC) transporter
CBG49_RS10855	COG1131	(ABC) transporter
CBG49_RS10860	COG0842	Transport permease protein
CBG49_RS10865	COG1129	ABC transporter
CBG49_RS10865	COG0842	Transport permease protein
CBG49_RS10890	COG2223	nitrite transmembrane transporter activity
CBG49_RS10895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CBG49_RS10900	COG0138	bifunctional purine biosynthesis protein purh
CBG49_RS10935	COG2268	Band 7 protein
CBG49_RS10955	COG1045	serine acetyltransferase
CBG49_RS10960	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CBG49_RS10960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CBG49_RS10970	COG0792	nuclease activity
CBG49_RS11000	COG0009	L-threonylcarbamoyladenylate synthase
CBG49_RS11005	COG2050	protein possibly involved in aromatic compounds catabolism
CBG49_RS11010	COG0339	signal peptide processing
CBG49_RS11030	COG0786	glutamate:sodium symporter activity
CBG49_RS11035	COG0217	transcriptional regulatory protein
CBG49_RS11045	COG0688	phosphatidylethanolamine metabolic process
CBG49_RS11060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBG49_RS11065	COG0612	Peptidase, M16
CBG49_RS11070	COG0612	Peptidase, M16
CBG49_RS11090	COG1696	Membrane protein involved in D-alanine export
CBG49_RS11105	COG0484	heat shock protein binding
CBG49_RS11135	COG2177	Part of the ABC transporter FtsEX involved in
CBG49_RS11165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CBG49_RS11175	COG3876	Protein conserved in bacteria
CBG49_RS11190	COG0826	peptidase U32
CBG49_RS11195	COG1968	undecaprenyl-diphosphatase activity
CBG49_RS11200	COG0671	phosphoesterase, PA-phosphatase related
CBG49_RS11205	COG2226	methyltransferase
CBG49_RS11210	COG1477	protein flavinylation
CBG49_RS11215	COG1477	protein flavinylation
CBG49_RS11220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CBG49_RS11240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CBG49_RS11250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CBG49_RS11260	COG1114	Component of the transport system for branched-chain amino acids
CBG49_RS11270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CBG49_RS11285	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CBG49_RS11290	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CBG49_RS11295	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CBG49_RS11300	COG1805	sodium ion transport
CBG49_RS11325	COG0552	protein localization to endoplasmic reticulum
CBG49_RS11335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CBG49_RS11340	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CBG49_RS11355	COG0443	Heat shock 70 kDa protein
CBG49_RS11360	COG0542	response to heat
CBG49_RS11390	COG0840	transmembrane signaling receptor activity
CBG49_RS11395	COG1862	Preprotein translocase
CBG49_RS11400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CBG49_RS11405	COG0776	regulation of translation
CBG49_RS11410	COG4848	Belongs to the UPF0354 family
CBG49_RS11420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CBG49_RS11430	COG0284	orotidine-5'-phosphate decarboxylase activity
CBG49_RS11440	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CBG49_RS11445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CBG49_RS11460	COG0254	rRNA binding
CBG49_RS11475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CBG49_RS11490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CBG49_RS11505	COG0463	Glycosyl transferase, family 2
CBG49_RS11510	COG0156	8-amino-7-oxononanoate synthase activity
CBG49_RS11530	COG0813	purine-nucleoside phosphorylase activity
CBG49_RS11535	COG3437	response regulator, receiver
CBG49_RS11535	COG3850	Histidine kinase
CBG49_RS11535	COG3437	response regulator, receiver
CBG49_RS11535	COG2205	protein histidine kinase activity
CBG49_RS11535	COG2205	protein histidine kinase activity
CBG49_RS11535	COG4999	Histidine kinase
CBG49_RS11535	COG4999	Histidine kinase
CBG49_RS11535	COG3850	Histidine kinase
CBG49_RS11600	COG2304	oxidoreductase activity
CBG49_RS11620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CBG49_RS11645	COG4206	TonB-dependent receptor
CBG49_RS11645	COG1629	transport
CBG49_RS11670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CBG49_RS11675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CBG49_RS11695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CBG49_RS11700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBG49_RS11720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CBG49_RS11735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CBG49_RS11745	COG0019	diaminopimelate decarboxylase activity
CBG49_RS11755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CBG49_RS11800	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CBG49_RS11805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CBG49_RS11810	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CBG49_RS11815	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CBG49_RS11815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CBG49_RS11820	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CBG49_RS11825	COG1078	dGTPase activity
CBG49_RS11830	COG1368	sulfuric ester hydrolase activity
CBG49_RS11835	COG0592	DNA-directed DNA polymerase activity
CBG49_RS11845	COG1132	(ABC) transporter
CBG49_RS11855	COG1522	sequence-specific DNA binding
CBG49_RS11860	COG1428	Deoxynucleoside kinase
CBG49_RS11875	COG0205	6-phosphofructokinase activity
CBG49_RS11885	COG2195	Cleaves the N-terminal amino acid of tripeptides
CBG49_RS11900	COG1137	ATPase activity
CBG49_RS11910	COG0805	protein transport
CBG49_RS11915	COG2885	chlorophyll binding
CBG49_RS11925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CBG49_RS11940	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CBG49_RS11945	COG4589	Belongs to the CDS family
CBG49_RS11970	COG0252	asparaginase activity
CBG49_RS11975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CBG49_RS11985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CBG49_RS11995	COG2267	carboxylic ester hydrolase activity
CBG49_RS12000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CBG49_RS12010	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CBG49_RS12035	COG0268	Binds directly to 16S ribosomal RNA
CBG49_RS12060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CBG49_RS12065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CBG49_RS12070	COG1181	Belongs to the D-alanine--D-alanine ligase family
CBG49_RS12085	COG1160	GTP binding
CBG49_RS12100	COG2184	nucleotidyltransferase activity
CBG49_RS12130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CBG49_RS12150	COG0275	rRNA processing
CBG49_RS12165	COG1482	cell wall glycoprotein biosynthetic process
CBG49_RS12170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBG49_RS12175	COG0708	Exodeoxyribonuclease III
CBG49_RS12205	COG4717	serine-type aminopeptidase activity
CBG49_RS12210	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CBG49_RS12230	COG5434	Belongs to the glycosyl hydrolase 28 family
CBG49_RS12235	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CBG49_RS12240	COG1022	Amp-dependent synthetase and ligase
CBG49_RS12245	COG0196	riboflavin kinase activity
CBG49_RS12255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CBG49_RS12260	COG1185	polyribonucleotide nucleotidyltransferase activity
CBG49_RS12275	COG3177	Filamentation induced by cAMP protein fic
CBG49_RS12290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CBG49_RS12320	COG1288	antiporter activity
CBG49_RS12340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CBG49_RS12340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CBG49_RS12345	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CBG49_RS12350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CBG49_RS12365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CBG49_RS12405	COG2304	oxidoreductase activity
CBG49_RS12415	COG2304	oxidoreductase activity
CBG49_RS12420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CBG49_RS12425	COG2949	membrane
CBG49_RS12430	COG2204	response regulator
CBG49_RS12440	COG1663	tetraacyldisaccharide 4'-kinase activity
CBG49_RS12455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CBG49_RS12470	COG1528	Iron-storage protein
CBG49_RS12505	COG1028	Short-chain dehydrogenase reductase Sdr
CBG49_RS12520	COG0297	glycogen (starch) synthase activity
CBG49_RS12525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CBG49_RS12535	COG2304	oxidoreductase activity
CBG49_RS12540	COG2304	oxidoreductase activity
CBG49_RS12545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CBG49_RS12585	COG1629	transport
CBG49_RS12585	COG4206	TonB-dependent receptor
CBG49_RS12600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CBG49_RS12615	COG0825	malonyl-CoA metabolic process
CBG49_RS12625	COG0509	glycine decarboxylation via glycine cleavage system
CBG49_RS12700	COG0305	Participates in initiation and elongation during chromosome replication
CBG49_RS12705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CBG49_RS12715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CBG49_RS12720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CBG49_RS12720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CBG49_RS12765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CBG49_RS12800	COG0673	inositol 2-dehydrogenase activity
CBG49_RS12805	COG1739	Uncharacterized protein family UPF0029
CBG49_RS12820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CBG49_RS12825	COG0356	it plays a direct role in the translocation of protons across the membrane
CBG49_RS12830	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBG49_RS12835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CBG49_RS12840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CBG49_RS12845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CBG49_RS12855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CBG49_RS12860	COG1187	pseudouridine synthase activity
CBG49_RS12865	COG2255	four-way junction helicase activity
CBG49_RS12885	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CBG49_RS12895	COG0242	peptide deformylase activity
CBG49_RS12900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CBG49_RS12905	COG0739	heme binding
CBG49_RS12910	COG0251	oxidation-reduction process
CBG49_RS12940	COG2226	methyltransferase
CBG49_RS12945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CBG49_RS12950	COG0045	succinate-CoA ligase (ADP-forming) activity
CBG49_RS12955	COG0405	Gamma-glutamyltransferase
CBG49_RS12965	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CBG49_RS12990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CBG49_RS12995	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CBG49_RS13005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CBG49_RS13030	COG1428	Deoxynucleoside kinase
CBG49_RS13035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CBG49_RS13050	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CBG49_RS13055	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CBG49_RS13060	COG1760	l-serine dehydratase
CBG49_RS13070	COG0840	transmembrane signaling receptor activity
CBG49_RS13075	COG0840	transmembrane signaling receptor activity
CBG49_RS13080	COG1022	Amp-dependent synthetase and ligase
CBG49_RS13085	COG0564	pseudouridine synthase activity
CBG49_RS13095	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CBG49_RS13115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CBG49_RS13140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CBG49_RS13150	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CBG49_RS13175	COG0439	Biotin carboxylase
CBG49_RS13180	COG0511	ligase activity, forming carbon-carbon bonds
CBG49_RS13185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBG49_RS13190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CBG49_RS13210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CBG49_RS13215	COG4771	TonB-dependent receptor
CBG49_RS13240	COG0527	aspartate kinase activity
CBG49_RS13255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CBG49_RS13255	COG0321	lipoyl(octanoyl) transferase activity
CBG49_RS13260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CBG49_RS13270	COG0148	phosphopyruvate hydratase activity
CBG49_RS13280	COG0505	Belongs to the CarA family
CBG49_RS13295	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CBG49_RS13300	COG4953	penicillin-binding protein 1C
CBG49_RS13320	COG0632	four-way junction helicase activity
CBG49_RS13340	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CBG49_RS13345	COG0459	protein refolding
CBG49_RS13380	COG3956	TIGRFAM MazG family protein
CBG49_RS13465	COG0124	histidyl-tRNA synthetase
CBG49_RS13475	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CBG49_RS13495	COG0017	Asparaginyl-tRNA synthetase
CBG49_RS13500	COG0181	hydroxymethylbilane synthase activity
CBG49_RS13510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CBG49_RS13515	COG1136	(ABC) transporter
CBG49_RS13575	COG0577	efflux transmembrane transporter activity
CBG49_RS13575	COG1136	(ABC) transporter
CBG49_RS13590	COG3275	phosphorelay sensor kinase activity
CBG49_RS13635	COG3279	Response regulator of the LytR AlgR family
CBG49_RS13640	COG3275	phosphorelay sensor kinase activity
CBG49_RS13650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CBG49_RS13655	COG1834	amidinotransferase
CBG49_RS13660	COG1271	oxidase subunit
CBG49_RS13665	COG1294	oxidase, subunit
CBG49_RS13680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CBG49_RS13685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CBG49_RS13690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CBG49_RS13700	COG4974	Belongs to the 'phage' integrase family
CBG49_RS13710	COG1132	(ABC) transporter
CBG49_RS13715	COG4676	Protein conserved in bacteria
CBG49_RS13755	COG0511	ligase activity, forming carbon-carbon bonds
CBG49_RS13765	COG3584	3D domain protein
CBG49_RS13765	COG1388	LysM domain
CBG49_RS13770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CBG49_RS13780	COG1774	PSP1 C-terminal conserved region
CBG49_RS13785	COG1696	Membrane protein involved in D-alanine export
CBG49_RS13795	COG0488	(ABC) transporter
CBG49_RS13840	COG1566	PFAM secretion protein HlyD family protein
CBG49_RS13860	COG2204	response regulator
CBG49_RS13875	COG1472	Belongs to the glycosyl hydrolase 3 family
CBG49_RS13885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CBG49_RS13890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CBG49_RS13900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CBG49_RS13920	COG1674	ftsk spoiiie
CBG49_RS13925	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CBG49_RS13930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CBG49_RS13930	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CBG49_RS13940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CBG49_RS13960	COG1136	(ABC) transporter
CBG49_RS13975	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CBG49_RS13990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CBG49_RS14040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CBG49_RS14050	COG0671	phosphoesterase, PA-phosphatase related
CBG49_RS14065	COG0653	protein targeting
CBG49_RS14095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CBG49_RS14100	COG0776	regulation of translation
CBG49_RS14105	COG1530	ribonuclease E activity
CBG49_RS14130	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CBG49_RS14155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CBG49_RS14160	COG4589	Belongs to the CDS family
CBG49_RS14175	COG2267	carboxylic ester hydrolase activity
CBG49_RS14180	COG2226	methyltransferase
CBG49_RS14215	COG0456	acetyltransferase
CBG49_RS14305	COG0602	queuosine metabolic process
CBG49_RS14320	COG0180	Tryptophanyl-tRNA synthetase
CBG49_RS14325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CBG49_RS14345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CBG49_RS14350	COG0460	homoserine dehydrogenase
CBG49_RS14350	COG0527	aspartate kinase activity
CBG49_RS14355	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CBG49_RS14355	COG0456	acetyltransferase
CBG49_RS14360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CBG49_RS14365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CBG49_RS14390	COG2954	triphosphatase activity
CBG49_RS14395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CBG49_RS14410	COG0525	valine-tRNA ligase activity
CBG49_RS14415	COG2171	N-acyltransferase activity
CBG49_RS14430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBG49_RS14440	COG0616	signal peptide processing
CBG49_RS14445	COG0175	sulfate reduction
CBG49_RS14460	COG1607	acyl-coa hydrolase
CBG49_RS14475	COG2890	protein-(glutamine-N5) methyltransferase activity
CBG49_RS14480	COG1705	Flagellar rod assembly protein muramidase FlgJ
CBG49_RS14480	COG3951	Flagellar rod assembly protein muramidase FlgJ
CBG49_RS14490	COG0577	efflux transmembrane transporter activity
CBG49_RS14530	COG0305	Participates in initiation and elongation during chromosome replication
CBG49_RS14550	COG3179	chitinase
CBG49_RS14625	COG0542	response to heat
CBG49_RS14675	COG0739	heme binding
CBG49_RS14730	COG0484	heat shock protein binding
CBG49_RS14780	COG0589	response to stress
CBG49_RS14795	COG0779	Required for maturation of 30S ribosomal subunits
CBG49_RS14800	COG2251	uridine kinase activity
CBG49_RS14800	COG0195	Participates in both transcription termination and antitermination
CBG49_RS14805	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CBG49_RS14810	COG3279	Response regulator of the LytR AlgR family
CBG49_RS14820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CBG49_RS14890	COG0470	DNA polymerase III
CBG49_RS14935	COG0861	Integral membrane protein TerC family
CBG49_RS14950	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CBG49_RS14990	COG4221	oxidoreductase activity
CBG49_RS15015	COG0396	ATPase activity
CBG49_RS15030	COG0719	Fe-S assembly protein
CBG49_RS15035	COG1253	flavin adenine dinucleotide binding
CBG49_RS15045	COG0203	ribosomal protein L17
CBG49_RS15050	COG0202	RNA polymerase activity
CBG49_RS15055	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CBG49_RS15060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CBG49_RS15065	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CBG49_RS15070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CBG49_RS15075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CBG49_RS15080	COG0201	protein transport
CBG49_RS15085	COG0200	Binds to the 23S rRNA
CBG49_RS15090	COG1841	ribosomal large subunit assembly
CBG49_RS15095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CBG49_RS15100	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CBG49_RS15105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CBG49_RS15110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CBG49_RS15115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CBG49_RS15120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CBG49_RS15125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CBG49_RS15130	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CBG49_RS15135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CBG49_RS15140	COG0255	Belongs to the universal ribosomal protein uL29 family
CBG49_RS15145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CBG49_RS15150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CBG49_RS15155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CBG49_RS15160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CBG49_RS15165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CBG49_RS15170	COG0089	rRNA binding
CBG49_RS15175	COG0088	Forms part of the polypeptide exit tunnel
CBG49_RS15180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CBG49_RS15185	COG0051	transcription antitermination factor activity, RNA binding
CBG49_RS15190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CBG49_RS15195	COG0049	tRNA binding
CBG49_RS15200	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CBG49_RS15225	COG1764	response to oxidative stress
CBG49_RS15255	COG4941	Belongs to the sigma-70 factor family
CBG49_RS15330	COG0656	L-ascorbic acid biosynthetic process
CBG49_RS15355	COG0789	Transcriptional regulator
CBG49_RS15360	COG1028	Short-chain dehydrogenase reductase Sdr
CBG49_RS15365	COG2207	Transcriptional regulator
CBG49_RS15415	COG3275	phosphorelay sensor kinase activity
CBG49_RS15420	COG3279	Response regulator of the LytR AlgR family
CBG49_RS15430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CBG49_RS15445	COG0517	IMP dehydrogenase activity
CBG49_RS15445	COG1125	glycine betaine transport
CBG49_RS15450	COG1063	alcohol dehydrogenase
CBG49_RS15465	COG2176	DNA-directed DNA polymerase activity
CBG49_RS15475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CBG49_RS15500	COG2249	NAD(P)H dehydrogenase (quinone) activity
CBG49_RS15515	COG1733	regulation of RNA biosynthetic process
CBG49_RS15520	COG2249	NAD(P)H dehydrogenase (quinone) activity
CBG49_RS15525	COG1733	regulation of RNA biosynthetic process
CBG49_RS15600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CBG49_RS15605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CBG49_RS15630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CBG49_RS15640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CBG49_RS15675	COG4974	Belongs to the 'phage' integrase family