locus-tag	class	description
FOC45_RS00010	COG1505	serine-type exopeptidase activity
FOC45_RS00015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FOC45_RS00040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FOC45_RS00050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FOC45_RS00055	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FOC45_RS00060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FOC45_RS00075	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
FOC45_RS00110	COG4771	TonB-dependent receptor
FOC45_RS00115	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FOC45_RS00135	COG0022	dehydrogenase e1 component
FOC45_RS00135	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC45_RS00145	COG4771	TonB-dependent receptor
FOC45_RS00155	COG2194	sulfuric ester hydrolase activity
FOC45_RS00180	COG0456	acetyltransferase
FOC45_RS00210	COG1519	Transferase
FOC45_RS00210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FOC45_RS00230	COG0306	phosphate transporter
FOC45_RS00235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FOC45_RS00240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FOC45_RS00245	COG0823	Involved in the tonB-independent uptake of proteins
FOC45_RS00245	COG1506	peptidase
FOC45_RS00275	COG0562	UDP-galactopyranose mutase
FOC45_RS00285	COG2244	polysaccharide biosynthetic process
FOC45_RS00300	COG2244	polysaccharide biosynthetic process
FOC45_RS00310	COG1442	glycosyl transferase family 8
FOC45_RS00310	COG1216	Glycosyl transferase, family 2
FOC45_RS00315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FOC45_RS00320	COG0438	transferase activity, transferring glycosyl groups
FOC45_RS00330	COG1215	transferase activity, transferring glycosyl groups
FOC45_RS00335	COG1216	Glycosyl transferase, family 2
FOC45_RS00355	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FOC45_RS00380	COG0175	sulfate reduction
FOC45_RS00390	COG1620	l-lactate permease
FOC45_RS00395	COG1702	phosphate starvation-inducible protein PhoH
FOC45_RS00400	COG0516	GMP reductase activity
FOC45_RS00400	COG0517	IMP dehydrogenase activity
FOC45_RS00445	COG1629	transport
FOC45_RS00450	COG0594	ribonuclease P activity
FOC45_RS00460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FOC45_RS00490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FOC45_RS00495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FOC45_RS00500	COG0052	Belongs to the universal ribosomal protein uS2 family
FOC45_RS00505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FOC45_RS00555	COG0037	tRNA processing
FOC45_RS00595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FOC45_RS00600	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FOC45_RS00615	COG3588	fructose-bisphosphate aldolase
FOC45_RS00630	COG0193	aminoacyl-tRNA hydrolase activity
FOC45_RS00635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC45_RS00665	COG2373	Large extracellular alpha-helical protein
FOC45_RS00680	COG0596	Alpha beta hydrolase
FOC45_RS00685	COG1950	PFAM Membrane protein of
FOC45_RS00695	COG0564	pseudouridine synthase activity
FOC45_RS00700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FOC45_RS00730	COG3005	denitrification pathway
FOC45_RS00735	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FOC45_RS00745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FOC45_RS00755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FOC45_RS00760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FOC45_RS00830	COG1629	transport
FOC45_RS00830	COG4206	TonB-dependent receptor
FOC45_RS00835	COG0702	epimerase
FOC45_RS00840	COG0471	metal ion transport
FOC45_RS00850	COG1418	mRNA catabolic process
FOC45_RS00890	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FOC45_RS00895	COG4804	nuclease activity
FOC45_RS00905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FOC45_RS00930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FOC45_RS00935	COG0750	zinc metalloprotease
FOC45_RS00940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOC45_RS00945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOC45_RS00970	COG0463	Glycosyl transferase, family 2
FOC45_RS00975	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FOC45_RS00975	COG1918	ferrous iron import across plasma membrane
FOC45_RS01010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FOC45_RS01040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FOC45_RS01085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FOC45_RS01105	COG0445	tRNA wobble uridine modification
FOC45_RS01120	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FOC45_RS01155	COG4771	TonB-dependent receptor
FOC45_RS01175	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FOC45_RS01190	COG0469	pyruvate kinase activity
FOC45_RS01200	COG1114	Component of the transport system for branched-chain amino acids
FOC45_RS01295	COG0113	porphobilinogen synthase activity
FOC45_RS01305	COG0126	phosphoglycerate kinase activity
FOC45_RS01315	COG3059	membrane
FOC45_RS01325	COG1253	flavin adenine dinucleotide binding
FOC45_RS01330	COG2353	YceI-like domain
FOC45_RS01340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FOC45_RS01345	COG3530	Putative quorum-sensing-regulated virulence factor
FOC45_RS01360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FOC45_RS01370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FOC45_RS01385	COG1077	Cell shape determining protein MreB Mrl
FOC45_RS01390	COG1792	Involved in formation and maintenance of cell shape
FOC45_RS01405	COG0424	maF-like protein
FOC45_RS01415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FOC45_RS01420	COG0556	nucleotide-excision repair
FOC45_RS01445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FOC45_RS01450	COG2986	histidine ammonia-lyase
FOC45_RS01455	COG2706	6-phosphogluconolactonase activity
FOC45_RS01460	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FOC45_RS01470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOC45_RS01510	COG1490	D-aminoacyl-tRNA deacylase activity
FOC45_RS01515	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
FOC45_RS01515	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
FOC45_RS01520	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FOC45_RS01550	COG0259	pyridoxamine-phosphate oxidase activity
FOC45_RS01555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOC45_RS01575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FOC45_RS01580	COG0081	regulation of translation
FOC45_RS01585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FOC45_RS01590	COG0222	ribosome binding
FOC45_RS01600	COG0085	RNA polymerase activity
FOC45_RS01605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FOC45_RS01620	COG0653	protein targeting
FOC45_RS01630	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FOC45_RS01640	COG4717	serine-type aminopeptidase activity
FOC45_RS01645	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FOC45_RS01650	COG0708	Exodeoxyribonuclease III
FOC45_RS01655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC45_RS01660	COG1482	cell wall glycoprotein biosynthetic process
FOC45_RS01675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FOC45_RS01680	COG0484	heat shock protein binding
FOC45_RS01685	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FOC45_RS01695	COG1629	transport
FOC45_RS01695	COG4206	TonB-dependent receptor
FOC45_RS01700	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FOC45_RS01710	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FOC45_RS01745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FOC45_RS01780	COG0671	phosphoesterase, PA-phosphatase related
FOC45_RS01810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FOC45_RS01820	COG1472	Belongs to the glycosyl hydrolase 3 family
FOC45_RS01830	COG2204	response regulator
FOC45_RS01835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FOC45_RS01840	COG0776	regulation of translation
FOC45_RS01845	COG1530	ribonuclease E activity
FOC45_RS01855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FOC45_RS01855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FOC45_RS01860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOC45_RS01865	COG1216	Glycosyl transferase, family 2
FOC45_RS01865	COG0463	Glycosyl transferase, family 2
FOC45_RS01875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FOC45_RS01880	COG0719	Fe-S assembly protein
FOC45_RS01925	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FOC45_RS01960	COG1162	GTPase activity
FOC45_RS01975	COG1132	(ABC) transporter
FOC45_RS02000	COG0783	Belongs to the Dps family
FOC45_RS02020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOC45_RS02030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FOC45_RS02035	COG0124	histidyl-tRNA synthetase
FOC45_RS02040	COG2226	methyltransferase
FOC45_RS02045	COG3956	TIGRFAM MazG family protein
FOC45_RS02055	COG0527	aspartate kinase activity
FOC45_RS02060	COG3022	response to hydroperoxide
FOC45_RS02070	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FOC45_RS02075	COG0632	four-way junction helicase activity
FOC45_RS02080	COG0459	protein refolding
FOC45_RS02085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FOC45_RS02120	COG0045	succinate-CoA ligase (ADP-forming) activity
FOC45_RS02125	COG0405	Gamma-glutamyltransferase
FOC45_RS02130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FOC45_RS02150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FOC45_RS02175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FOC45_RS02175	COG0321	lipoyl(octanoyl) transferase activity
FOC45_RS02180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FOC45_RS02190	COG0148	phosphopyruvate hydratase activity
FOC45_RS02200	COG0505	Belongs to the CarA family
FOC45_RS02215	COG0366	Alpha amylase catalytic
FOC45_RS02310	COG0540	Belongs to the ATCase OTCase family
FOC45_RS02340	COG4676	Protein conserved in bacteria
FOC45_RS02350	COG0251	oxidation-reduction process
FOC45_RS02355	COG0739	heme binding
FOC45_RS02360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FOC45_RS02395	COG1739	Uncharacterized protein family UPF0029
FOC45_RS02400	COG0673	inositol 2-dehydrogenase activity
FOC45_RS02420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOC45_RS02425	COG0356	it plays a direct role in the translocation of protons across the membrane
FOC45_RS02430	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOC45_RS02435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FOC45_RS02440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOC45_RS02445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FOC45_RS02455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FOC45_RS02460	COG1187	pseudouridine synthase activity
FOC45_RS02465	COG2255	four-way junction helicase activity
FOC45_RS02470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FOC45_RS02475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC45_RS02480	COG0511	ligase activity, forming carbon-carbon bonds
FOC45_RS02485	COG0439	Biotin carboxylase
FOC45_RS02490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FOC45_RS02500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FOC45_RS02505	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC45_RS02520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOC45_RS02525	COG0840	transmembrane signaling receptor activity
FOC45_RS02530	COG0840	transmembrane signaling receptor activity
FOC45_RS02540	COG1022	Amp-dependent synthetase and ligase
FOC45_RS02545	COG0564	pseudouridine synthase activity
FOC45_RS02555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FOC45_RS02560	COG1428	Deoxynucleoside kinase
FOC45_RS02565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FOC45_RS02580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FOC45_RS02590	COG0442	prolyl-tRNA aminoacylation
FOC45_RS02595	COG0793	Belongs to the peptidase S41A family
FOC45_RS02605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOC45_RS02605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FOC45_RS02635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FOC45_RS02645	COG1185	polyribonucleotide nucleotidyltransferase activity
FOC45_RS02650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FOC45_RS02655	COG1217	gtp-binding protein TYPA
FOC45_RS02685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FOC45_RS02690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOC45_RS02700	COG0305	Participates in initiation and elongation during chromosome replication
FOC45_RS02715	COG0509	glycine decarboxylation via glycine cleavage system
FOC45_RS02735	COG0825	malonyl-CoA metabolic process
FOC45_RS02740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FOC45_RS02750	COG4772	TonB-dependent receptor
FOC45_RS02765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FOC45_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
FOC45_RS02800	COG0297	glycogen (starch) synthase activity
FOC45_RS02805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FOC45_RS02825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOC45_RS02850	COG1629	transport
FOC45_RS02860	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FOC45_RS02870	COG2885	chlorophyll binding
FOC45_RS02895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FOC45_RS02920	COG0802	atpase or kinase
FOC45_RS02925	COG4948	Mandelate Racemase Muconate Lactonizing
FOC45_RS02930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOC45_RS02930	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FOC45_RS02940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC45_RS02970	COG0275	rRNA processing
FOC45_RS02985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FOC45_RS02990	COG1196	nuclear chromosome segregation
FOC45_RS02990	COG1674	ftsk spoiiie
FOC45_RS03000	COG4771	TonB-dependent receptor
FOC45_RS03010	COG3842	ATPase activity
FOC45_RS03025	COG1528	Iron-storage protein
FOC45_RS03035	COG1663	tetraacyldisaccharide 4'-kinase activity
FOC45_RS03045	COG2204	response regulator
FOC45_RS03050	COG2949	membrane
FOC45_RS03055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FOC45_RS03060	COG2304	oxidoreductase activity
FOC45_RS03070	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FOC45_RS03080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOC45_RS03095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOC45_RS03100	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FOC45_RS03105	COG0784	Response regulator, receiver
FOC45_RS03105	COG2205	protein histidine kinase activity
FOC45_RS03110	COG0813	purine-nucleoside phosphorylase activity
FOC45_RS03120	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FOC45_RS03125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FOC45_RS03180	COG1125	glycine betaine transport
FOC45_RS03185	COG1174	glycine betaine transport
FOC45_RS03205	COG3279	Response regulator of the LytR AlgR family
FOC45_RS03210	COG3275	phosphorelay sensor kinase activity
FOC45_RS03235	COG0463	Glycosyl transferase, family 2
FOC45_RS03240	COG0156	8-amino-7-oxononanoate synthase activity
FOC45_RS03250	COG1715	Restriction endonuclease
FOC45_RS03265	COG2885	chlorophyll binding
FOC45_RS03265	COG3047	cAMP biosynthetic process
FOC45_RS03275	COG4974	Belongs to the 'phage' integrase family
FOC45_RS03280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC45_RS03280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC45_RS03305	COG1288	antiporter activity
FOC45_RS03320	COG0481	GTPase activity
FOC45_RS03325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOC45_RS03330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC45_RS03335	COG4771	TonB-dependent receptor
FOC45_RS03340	COG0702	epimerase
FOC45_RS03370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOC45_RS03375	COG1629	transport
FOC45_RS03380	COG0702	epimerase
FOC45_RS03385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOC45_RS03410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FOC45_RS03445	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FOC45_RS03490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FOC45_RS03510	COG2304	oxidoreductase activity
FOC45_RS03515	COG0254	rRNA binding
FOC45_RS03535	COG1764	response to oxidative stress
FOC45_RS03545	COG0656	L-ascorbic acid biosynthetic process
FOC45_RS03560	COG1917	Cupin 2, conserved barrel domain protein
FOC45_RS03560	COG4977	sequence-specific DNA binding
FOC45_RS03585	COG4941	Belongs to the sigma-70 factor family
FOC45_RS03655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FOC45_RS03660	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FOC45_RS03670	COG0284	orotidine-5'-phosphate decarboxylase activity
FOC45_RS03680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOC45_RS03685	COG0776	regulation of translation
FOC45_RS03690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOC45_RS03695	COG1862	Preprotein translocase
FOC45_RS03700	COG0840	transmembrane signaling receptor activity
FOC45_RS03715	COG0009	L-threonylcarbamoyladenylate synthase
FOC45_RS03720	COG2050	protein possibly involved in aromatic compounds catabolism
FOC45_RS03730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FOC45_RS03755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOC45_RS03770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FOC45_RS03775	COG0228	four-way junction DNA binding
FOC45_RS03780	COG1136	(ABC) transporter
FOC45_RS03780	COG0577	efflux transmembrane transporter activity
FOC45_RS03790	COG3951	Flagellar rod assembly protein muramidase FlgJ
FOC45_RS03790	COG1705	Flagellar rod assembly protein muramidase FlgJ
FOC45_RS03795	COG2890	protein-(glutamine-N5) methyltransferase activity
FOC45_RS03800	COG0539	negative regulation of cytoplasmic translation
FOC45_RS03815	COG4152	abc transporter atp-binding protein
FOC45_RS03825	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FOC45_RS03830	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FOC45_RS03840	COG2733	membrane
FOC45_RS03845	COG0343	queuine tRNA-ribosyltransferase activity
FOC45_RS03855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FOC45_RS03860	COG2239	Acts as a magnesium transporter
FOC45_RS03870	COG0233	cytoplasmic translational termination
FOC45_RS03890	COG0528	UMP kinase activity
FOC45_RS03915	COG0714	Associated with various cellular activities
FOC45_RS03940	COG2304	oxidoreductase activity
FOC45_RS03945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FOC45_RS03965	COG1760	l-serine dehydratase
FOC45_RS03970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FOC45_RS03985	COG2843	Capsule synthesis protein
FOC45_RS03995	COG1266	CAAX protease self-immunity
FOC45_RS04000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FOC45_RS04005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FOC45_RS04010	COG0149	triose-phosphate isomerase activity
FOC45_RS04015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FOC45_RS04025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FOC45_RS04030	COG4206	TonB-dependent receptor
FOC45_RS04030	COG1629	transport
FOC45_RS04045	COG0084	hydrolase, TatD family'
FOC45_RS04055	COG0484	heat shock protein binding
FOC45_RS04065	COG0681	Belongs to the peptidase S26 family
FOC45_RS04070	COG0561	phosphatase activity
FOC45_RS04075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FOC45_RS04085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FOC45_RS04090	COG1295	ribonuclease BN
FOC45_RS04095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FOC45_RS04105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FOC45_RS04105	COG0519	Catalyzes the synthesis of GMP from XMP
FOC45_RS04110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FOC45_RS04120	COG0504	CTP synthase activity
FOC45_RS04125	COG0706	membrane insertase activity
FOC45_RS04130	COG0363	glucosamine-6-phosphate deaminase activity
FOC45_RS04145	COG0688	phosphatidylethanolamine metabolic process
FOC45_RS04155	COG0217	transcriptional regulatory protein
FOC45_RS04160	COG0517	IMP dehydrogenase activity
FOC45_RS04160	COG0516	GMP reductase activity
FOC45_RS04165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FOC45_RS04170	COG0569	domain protein
FOC45_RS04175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FOC45_RS04180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FOC45_RS04185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FOC45_RS04240	COG0612	Peptidase, M16
FOC45_RS04255	COG0492	ferredoxin-NADP+ reductase activity
FOC45_RS04260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FOC45_RS04275	COG0617	tRNA 3'-terminal CCA addition
FOC45_RS04275	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FOC45_RS04275	COG0517	IMP dehydrogenase activity
FOC45_RS04280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FOC45_RS04285	COG2095	MarC family integral membrane protein
FOC45_RS04290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FOC45_RS04290	COG1333	cytochrome c biogenesis protein
FOC45_RS04315	COG2226	methyltransferase
FOC45_RS04385	COG0542	response to heat
FOC45_RS04395	COG3501	Rhs element vgr protein
FOC45_RS04440	COG3501	Rhs element vgr protein
FOC45_RS04710	COG4974	Belongs to the 'phage' integrase family
FOC45_RS04735	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FOC45_RS04740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOC45_RS04750	COG0488	(ABC) transporter
FOC45_RS04770	COG2885	chlorophyll binding
FOC45_RS04775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FOC45_RS04785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOC45_RS04805	COG0295	cytidine deaminase activity
FOC45_RS04810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FOC45_RS04815	COG1506	peptidase
FOC45_RS04815	COG0823	Involved in the tonB-independent uptake of proteins
FOC45_RS04830	COG1970	mechanosensitive ion channel activity
FOC45_RS04835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FOC45_RS04840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FOC45_RS04845	COG0328	RNA-DNA hybrid ribonuclease activity
FOC45_RS04845	COG3341	Caulimovirus viroplasmin
FOC45_RS04860	COG0488	(ABC) transporter
FOC45_RS04915	COG1131	(ABC) transporter
FOC45_RS04925	COG1131	(ABC) transporter
FOC45_RS04930	COG1129	ABC transporter
FOC45_RS04930	COG0842	Transport permease protein
FOC45_RS04935	COG0842	Transport permease protein
FOC45_RS04945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC45_RS04950	COG3586	endonuclease activity
FOC45_RS04965	COG0544	peptidyl-prolyl cis-trans isomerase activity
FOC45_RS04970	COG0740	serine-type endopeptidase activity
FOC45_RS04975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FOC45_RS04990	COG0336	Belongs to the RNA methyltransferase TrmD family
FOC45_RS04995	COG0318	PFAM AMP-dependent synthetase and ligase
FOC45_RS05010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FOC45_RS05030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FOC45_RS05035	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FOC45_RS05055	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FOC45_RS05065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FOC45_RS05070	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FOC45_RS05090	COG1252	NADH dehydrogenase
FOC45_RS05105	COG1752	Esterase of the alpha-beta hydrolase superfamily
FOC45_RS05110	COG2195	Cleaves the N-terminal amino acid of tripeptides
FOC45_RS05130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOC45_RS05145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FOC45_RS05160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FOC45_RS05185	COG0628	permease
FOC45_RS05195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOC45_RS05200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FOC45_RS05205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FOC45_RS05220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC45_RS05235	COG1380	Effector of murein hydrolase LrgA
FOC45_RS05240	COG1346	cytolysis
FOC45_RS05270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC45_RS05285	COG1335	isochorismatase
FOC45_RS05300	COG2223	nitrite transmembrane transporter activity
FOC45_RS05305	COG0010	Belongs to the arginase family
FOC45_RS05310	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FOC45_RS05330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FOC45_RS05335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FOC45_RS05335	COG0116	Belongs to the methyltransferase superfamily
FOC45_RS05345	COG2226	methyltransferase
FOC45_RS05370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FOC45_RS05380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOC45_RS05390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FOC45_RS05395	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FOC45_RS05400	COG0490	domain, Protein
FOC45_RS05400	COG0471	metal ion transport
FOC45_RS05410	COG1104	cysteine desulfurase activity
FOC45_RS05420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FOC45_RS05425	COG1136	(ABC) transporter
FOC45_RS05430	COG1215	transferase activity, transferring glycosyl groups
FOC45_RS05435	COG0335	large ribosomal subunit rRNA binding
FOC45_RS05440	COG2176	DNA-directed DNA polymerase activity
FOC45_RS05450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FOC45_RS05455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FOC45_RS05465	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FOC45_RS05465	COG0517	IMP dehydrogenase activity
FOC45_RS05475	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FOC45_RS05485	COG0824	Thioesterase
FOC45_RS05490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FOC45_RS05495	COG0686	Belongs to the AlaDH PNT family
FOC45_RS05500	COG0514	ATP-dependent DNA helicase (RecQ)
FOC45_RS05510	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FOC45_RS05515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC45_RS05520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FOC45_RS05525	COG0194	GDP metabolic process
FOC45_RS05530	COG1561	YicC-like family, N-terminal region
FOC45_RS05560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FOC45_RS05590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FOC45_RS05600	COG0450	alkyl hydroperoxide reductase
FOC45_RS05605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FOC45_RS05615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC45_RS05620	COG0242	peptide deformylase activity
FOC45_RS05625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FOC45_RS05625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC45_RS05665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC45_RS05670	COG1230	cation diffusion facilitator family transporter
FOC45_RS05675	COG0798	PFAM Bile acid sodium symporter
FOC45_RS05685	COG4974	Belongs to the 'phage' integrase family
FOC45_RS05710	COG0482	sulfurtransferase activity
FOC45_RS05730	COG0101	tRNA pseudouridine synthase activity
FOC45_RS05740	COG0357	Ribosomal RNA small subunit methyltransferase G
FOC45_RS05750	COG0598	Magnesium transport protein CorA
FOC45_RS05770	COG0471	metal ion transport
FOC45_RS05815	COG0488	(ABC) transporter
FOC45_RS05830	COG1401	restriction endodeoxyribonuclease activity
FOC45_RS05835	COG1522	sequence-specific DNA binding
FOC45_RS05855	COG0497	DNA recombination
FOC45_RS05865	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOC45_RS05865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOC45_RS05875	COG0433	COG0433 Predicted ATPase
FOC45_RS05890	COG0827	DNA restriction-modification system
FOC45_RS05895	COG1381	Involved in DNA repair and RecF pathway recombination
FOC45_RS05900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FOC45_RS05905	COG0009	L-threonylcarbamoyladenylate synthase
FOC45_RS05910	COG1289	transmembrane transporter activity
FOC45_RS05925	COG0359	binds to the 23S rRNA
FOC45_RS05930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FOC45_RS05935	COG0360	Binds together with S18 to 16S ribosomal RNA
FOC45_RS05940	COG0612	Peptidase, M16
FOC45_RS05945	COG0612	Peptidase, M16
FOC45_RS05950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC45_RS05955	COG0167	dihydroorotate dehydrogenase activity
FOC45_RS05970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC45_RS05975	COG1120	ATPase activity
FOC45_RS05980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FOC45_RS05980	COG1648	precorrin-2 dehydrogenase activity
FOC45_RS06010	COG0521	Mo-molybdopterin cofactor biosynthetic process
FOC45_RS06010	COG0315	cyclic pyranopterin monophosphate synthase activity
FOC45_RS06015	COG0314	molybdopterin synthase activity
FOC45_RS06025	COG1193	negative regulation of DNA recombination
FOC45_RS06040	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FOC45_RS06045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FOC45_RS06055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FOC45_RS06060	COG3340	Belongs to the peptidase S51 family
FOC45_RS06065	COG2017	converts alpha-aldose to the beta-anomer
FOC45_RS06070	COG2356	endonuclease I
FOC45_RS06075	COG0514	ATP-dependent DNA helicase (RecQ)
FOC45_RS06080	COG0542	response to heat
FOC45_RS06085	COG0791	NLP P60 protein
FOC45_RS06090	COG0658	competence protein
FOC45_RS06090	COG2333	competence protein COMEC
FOC45_RS06110	COG0022	dehydrogenase e1 component
FOC45_RS06115	COG0179	Fumarylacetoacetate (FAA) hydrolase
FOC45_RS06130	COG0191	fructose-bisphosphate aldolase activity
FOC45_RS06135	COG0280	phosphate acetyltransferase
FOC45_RS06135	COG0857	belongs to the CobB CobQ family
FOC45_RS06140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FOC45_RS06145	COG1166	arginine decarboxylase activity
FOC45_RS06185	COG1404	Belongs to the peptidase S8 family
FOC45_RS06225	COG3591	Belongs to the peptidase S1B family
FOC45_RS06235	COG0012	GTP binding
FOC45_RS06240	COG3594	Acyltransferase
FOC45_RS06250	COG1169	isochorismate synthase
FOC45_RS06255	COG1132	(ABC) transporter
FOC45_RS06270	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FOC45_RS06285	COG0588	phosphoglycerate mutase activity
FOC45_RS06290	COG0438	transferase activity, transferring glycosyl groups
FOC45_RS06310	COG0243	molybdopterin cofactor binding
FOC45_RS06315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FOC45_RS06375	COG1999	signal sequence binding
FOC45_RS06380	COG0303	'Molybdopterin
FOC45_RS06390	COG0746	molybdenum cofactor guanylyltransferase activity
FOC45_RS06395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FOC45_RS06400	COG0302	gtp cyclohydrolase
FOC45_RS06405	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FOC45_RS06410	COG1304	FMN binding
FOC45_RS06415	COG2183	response to ionizing radiation
FOC45_RS06420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOC45_RS06435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOC45_RS06445	COG0737	Belongs to the 5'-nucleotidase family
FOC45_RS06450	COG0737	Belongs to the 5'-nucleotidase family
FOC45_RS06460	COG1538	Outer membrane efflux protein
FOC45_RS06465	COG1309	transcriptional regulator
FOC45_RS06480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FOC45_RS06485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FOC45_RS06490	COG4771	TonB-dependent receptor
FOC45_RS06510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FOC45_RS06515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC45_RS06520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FOC45_RS06525	COG2814	Major facilitator Superfamily
FOC45_RS06535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FOC45_RS06540	COG4452	Inner membrane protein CreD
FOC45_RS06570	COG0427	acetyl-CoA hydrolase
FOC45_RS06575	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FOC45_RS06580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FOC45_RS06585	COG0626	cystathionine gamma-synthase activity
FOC45_RS06590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FOC45_RS06600	COG1393	Belongs to the ArsC family
FOC45_RS06605	COG1349	DNA-binding transcription factor activity
FOC45_RS06615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FOC45_RS06635	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOC45_RS06640	COG1215	transferase activity, transferring glycosyl groups
FOC45_RS06655	COG1696	Membrane protein involved in D-alanine export
FOC45_RS06675	COG0501	Belongs to the peptidase M48B family
FOC45_RS06680	COG3757	hydrolase, family 25
FOC45_RS06685	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FOC45_RS06695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FOC45_RS06700	COG0138	bifunctional purine biosynthesis protein purh
FOC45_RS06750	COG1045	serine acetyltransferase
FOC45_RS06755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOC45_RS06765	COG0792	nuclease activity
FOC45_RS06780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FOC45_RS06790	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FOC45_RS06790	COG0662	Cupin 2, conserved barrel domain protein
FOC45_RS06985	COG4974	Belongs to the 'phage' integrase family
FOC45_RS06995	COG1899	peptidyl-lysine modification to peptidyl-hypusine
FOC45_RS07000	COG0215	cysteine-tRNA ligase activity
FOC45_RS07010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FOC45_RS07025	COG1395	domain, Protein
FOC45_RS07215	COG0606	chelatase, subunit chli
FOC45_RS07235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FOC45_RS07240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FOC45_RS07270	COG0326	Molecular chaperone. Has ATPase activity
FOC45_RS07275	COG2824	Alkylphosphonate utilization operon protein PhnA
FOC45_RS07290	COG1523	belongs to the glycosyl hydrolase 13 family
FOC45_RS07315	COG0339	signal peptide processing
FOC45_RS07320	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FOC45_RS07325	COG0786	glutamate:sodium symporter activity
FOC45_RS07330	COG0285	dihydrofolate synthase activity
FOC45_RS07345	COG0811	peptide transport
FOC45_RS07365	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FOC45_RS07370	COG2502	aspartate--ammonia ligase
FOC45_RS07380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FOC45_RS07385	COG3590	peptidase
FOC45_RS07390	COG0644	oxidoreductase
FOC45_RS07395	COG5434	Belongs to the glycosyl hydrolase 28 family
FOC45_RS07405	COG2264	protein methyltransferase activity
FOC45_RS07440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FOC45_RS07455	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FOC45_RS07460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FOC45_RS07470	COG0492	ferredoxin-NADP+ reductase activity
FOC45_RS07485	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FOC45_RS07525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FOC45_RS07540	COG0726	polysaccharide deacetylase
FOC45_RS07555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FOC45_RS07580	COG0826	peptidase U32
FOC45_RS07585	COG3876	Protein conserved in bacteria
FOC45_RS07600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FOC45_RS07605	COG0542	response to heat
FOC45_RS07610	COG0443	Heat shock 70 kDa protein
FOC45_RS07615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FOC45_RS07620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FOC45_RS07630	COG0552	protein localization to endoplasmic reticulum
FOC45_RS07650	COG1805	sodium ion transport
FOC45_RS07655	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FOC45_RS07660	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FOC45_RS07665	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FOC45_RS07680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC45_RS07685	COG3119	arylsulfatase activity
FOC45_RS07690	COG3250	beta-galactosidase activity
FOC45_RS07700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FOC45_RS07720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FOC45_RS07725	COG1477	protein flavinylation
FOC45_RS07730	COG1477	protein flavinylation
FOC45_RS07735	COG2226	methyltransferase
FOC45_RS07740	COG0671	phosphoesterase, PA-phosphatase related
FOC45_RS07745	COG1968	undecaprenyl-diphosphatase activity
FOC45_RS07755	COG2177	Part of the ABC transporter FtsEX involved in
FOC45_RS07765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOC45_RS07770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOC45_RS07790	COG0772	Belongs to the SEDS family
FOC45_RS07795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FOC45_RS07800	COG2321	neutral zinc metallopeptidase
FOC45_RS07805	COG0321	lipoyl(octanoyl) transferase activity
FOC45_RS07810	COG0563	adenylate kinase activity
FOC45_RS07855	COG1012	belongs to the aldehyde dehydrogenase family
FOC45_RS07860	COG0569	domain protein
FOC45_RS07860	COG2985	domain, Protein
FOC45_RS07865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FOC45_RS07870	COG1192	Involved in chromosome partitioning
FOC45_RS07875	COG1475	DNA binding
FOC45_RS07885	COG0277	FAD linked oxidase domain protein
FOC45_RS07910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FOC45_RS07925	COG0196	riboflavin kinase activity
FOC45_RS07930	COG1022	Amp-dependent synthetase and ligase
FOC45_RS07935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FOC45_RS07940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FOC45_RS07945	COG1181	Belongs to the D-alanine--D-alanine ligase family
FOC45_RS07960	COG1160	GTP binding
FOC45_RS07965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FOC45_RS07970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOC45_RS07975	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOC45_RS07980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FOC45_RS07985	COG0247	lactate metabolic process
FOC45_RS07985	COG2181	nitrate reductase activity
FOC45_RS08000	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FOC45_RS08005	COG0018	arginyl-trna synthetase
FOC45_RS08025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC45_RS08055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FOC45_RS08065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FOC45_RS08075	COG0019	diaminopimelate decarboxylase activity
FOC45_RS08095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FOC45_RS08105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FOC45_RS08115	COG4771	TonB-dependent receptor
FOC45_RS08135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOC45_RS08140	COG0799	negative regulation of ribosome biogenesis
FOC45_RS08150	COG0590	tRNA wobble adenosine to inosine editing
FOC45_RS08160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FOC45_RS08165	COG2884	Cell division ATP-binding protein ftsE
FOC45_RS08175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FOC45_RS08180	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FOC45_RS08185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FOC45_RS08185	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FOC45_RS08190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FOC45_RS08195	COG1078	dGTPase activity
FOC45_RS08200	COG1368	sulfuric ester hydrolase activity
FOC45_RS08205	COG0592	DNA-directed DNA polymerase activity
FOC45_RS08220	COG1132	(ABC) transporter
FOC45_RS08230	COG1522	sequence-specific DNA binding
FOC45_RS08235	COG1428	Deoxynucleoside kinase
FOC45_RS08250	COG0205	6-phosphofructokinase activity
FOC45_RS08260	COG2195	Cleaves the N-terminal amino acid of tripeptides
FOC45_RS08265	COG1137	ATPase activity
FOC45_RS08275	COG0805	protein transport
FOC45_RS08280	COG2885	chlorophyll binding
FOC45_RS08295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FOC45_RS08305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FOC45_RS08315	COG4589	Belongs to the CDS family
FOC45_RS08340	COG0252	asparaginase activity
FOC45_RS08345	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FOC45_RS08355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FOC45_RS08365	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FOC45_RS08375	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
FOC45_RS08400	COG0268	Binds directly to 16S ribosomal RNA
FOC45_RS08415	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC45_RS08420	COG1629	transport
FOC45_RS08425	COG0567	Dehydrogenase, E1 component
FOC45_RS08435	COG0242	peptide deformylase activity
FOC45_RS08445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FOC45_RS08475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FOC45_RS08500	COG0745	RESPONSE REGULATOR receiver
FOC45_RS08500	COG2205	protein histidine kinase activity
FOC45_RS08500	COG3292	Two component regulator propeller
FOC45_RS08515	COG1621	beta-fructofuranosidase activity
FOC45_RS08530	COG0702	epimerase
FOC45_RS08535	COG1629	transport
FOC45_RS08545	COG2837	iron assimilation
FOC45_RS08550	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FOC45_RS08555	COG2217	Heavy metal translocating P-type atpase
FOC45_RS08570	COG0714	Associated with various cellular activities
FOC45_RS08580	COG0673	inositol 2-dehydrogenase activity
FOC45_RS08600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FOC45_RS08610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FOC45_RS08645	COG2351	hydroxyisourate hydrolase activity
FOC45_RS08650	COG0463	Glycosyl transferase, family 2
FOC45_RS08660	COG0386	Belongs to the glutathione peroxidase family
FOC45_RS08675	COG1053	succinate dehydrogenase
FOC45_RS08695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FOC45_RS08720	COG0811	peptide transport
FOC45_RS08730	COG0252	asparaginase activity
FOC45_RS08740	COG0084	hydrolase, TatD family'
FOC45_RS08745	COG0702	epimerase
FOC45_RS08750	COG4206	TonB-dependent receptor
FOC45_RS08750	COG1629	transport
FOC45_RS08755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FOC45_RS08790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FOC45_RS08805	COG0187	DNA topoisomerase II activity
FOC45_RS08815	COG1271	oxidase subunit
FOC45_RS08820	COG1294	oxidase, subunit
FOC45_RS08835	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FOC45_RS08840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FOC45_RS08860	COG1774	PSP1 C-terminal conserved region
FOC45_RS08870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FOC45_RS08905	COG3275	phosphorelay sensor kinase activity
FOC45_RS08910	COG1136	(ABC) transporter
FOC45_RS08910	COG0577	efflux transmembrane transporter activity
FOC45_RS08965	COG1136	(ABC) transporter
FOC45_RS08970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FOC45_RS08980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FOC45_RS08985	COG1674	ftsk spoiiie
FOC45_RS09005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOC45_RS09010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FOC45_RS09020	COG1136	(ABC) transporter
FOC45_RS09045	COG0488	(ABC) transporter
FOC45_RS09055	COG1696	Membrane protein involved in D-alanine export
FOC45_RS09060	COG0017	Asparaginyl-tRNA synthetase
FOC45_RS09085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FOC45_RS09085	COG0512	Glutamine amidotransferase of anthranilate synthase
FOC45_RS09100	COG0134	indole-3-glycerol-phosphate synthase activity
FOC45_RS09115	COG0135	phosphoribosylanthranilate isomerase activity
FOC45_RS09120	COG0133	tryptophan synthase activity
FOC45_RS09140	COG0602	queuosine metabolic process
FOC45_RS09155	COG0180	Tryptophanyl-tRNA synthetase
FOC45_RS09165	COG0339	signal peptide processing
FOC45_RS09205	COG0025	NhaP-type Na H and K H
FOC45_RS09245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FOC45_RS09250	COG0322	excinuclease ABC activity
FOC45_RS09295	COG3119	arylsulfatase activity
FOC45_RS09340	COG3104	oligopeptide transport
FOC45_RS09345	COG0758	DNA mediated transformation
FOC45_RS09345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOC45_RS09350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FOC45_RS09370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC45_RS09385	COG0571	ribonuclease III activity
FOC45_RS09390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOC45_RS09395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOC45_RS09415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FOC45_RS09420	COG0456	acetyltransferase
FOC45_RS09420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FOC45_RS09425	COG0460	homoserine dehydrogenase
FOC45_RS09425	COG0527	aspartate kinase activity
FOC45_RS09430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOC45_RS09435	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FOC45_RS09450	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FOC45_RS09485	COG2171	N-acyltransferase activity
FOC45_RS09490	COG0525	valine-tRNA ligase activity
FOC45_RS09495	COG2954	triphosphatase activity
FOC45_RS09525	COG0420	3'-5' exonuclease activity
FOC45_RS09530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FOC45_RS09530	COG0116	Belongs to the methyltransferase superfamily
FOC45_RS09535	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
FOC45_RS09545	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FOC45_RS09550	COG0772	Belongs to the SEDS family
FOC45_RS09555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FOC45_RS09560	COG1981	membrane
FOC45_RS09565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FOC45_RS09575	COG1435	thymidine kinase activity
FOC45_RS09585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOC45_RS09590	COG1012	belongs to the aldehyde dehydrogenase family
FOC45_RS09595	COG3279	Response regulator of the LytR AlgR family
FOC45_RS09605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FOC45_RS09610	COG0195	Participates in both transcription termination and antitermination
FOC45_RS09610	COG2251	uridine kinase activity
FOC45_RS09615	COG0779	Required for maturation of 30S ribosomal subunits
FOC45_RS09675	COG1629	transport
FOC45_RS09740	COG0396	ATPase activity
FOC45_RS09750	COG0719	Fe-S assembly protein
FOC45_RS09755	COG4221	oxidoreductase activity
FOC45_RS09765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOC45_RS09775	COG0616	signal peptide processing
FOC45_RS09780	COG0175	sulfate reduction
FOC45_RS09815	COG0470	DNA polymerase III
FOC45_RS09820	COG0861	Integral membrane protein TerC family
FOC45_RS09845	COG4206	TonB-dependent receptor
FOC45_RS09845	COG1629	transport
FOC45_RS09855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FOC45_RS09895	COG0237	dephospho-CoA kinase activity
FOC45_RS09920	COG1610	YqeY-like protein
FOC45_RS09945	COG2010	Cytochrome c
FOC45_RS09980	COG0423	glycine-tRNA ligase activity
FOC45_RS10055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FOC45_RS10065	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FOC45_RS10080	COG5000	phosphorelay sensor kinase activity
FOC45_RS10095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC45_RS10100	COG0203	ribosomal protein L17
FOC45_RS10105	COG0202	RNA polymerase activity
FOC45_RS10110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FOC45_RS10115	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FOC45_RS10120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FOC45_RS10125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FOC45_RS10130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FOC45_RS10135	COG0201	protein transport
FOC45_RS10140	COG0200	Binds to the 23S rRNA
FOC45_RS10145	COG1841	ribosomal large subunit assembly
FOC45_RS10150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FOC45_RS10155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FOC45_RS10160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FOC45_RS10165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FOC45_RS10170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FOC45_RS10175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FOC45_RS10180	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FOC45_RS10185	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FOC45_RS10190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FOC45_RS10195	COG0255	Belongs to the universal ribosomal protein uL29 family
FOC45_RS10200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FOC45_RS10205	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FOC45_RS10210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FOC45_RS10215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FOC45_RS10220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FOC45_RS10230	COG0088	Forms part of the polypeptide exit tunnel
FOC45_RS10235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FOC45_RS10240	COG0051	transcription antitermination factor activity, RNA binding
FOC45_RS10245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FOC45_RS10250	COG0049	tRNA binding
FOC45_RS10255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FOC45_RS10280	COG0288	reversible hydration of carbon dioxide
FOC45_RS10355	COG2814	Major facilitator Superfamily
FOC45_RS10365	COG2181	nitrate reductase activity
FOC45_RS10365	COG0247	lactate metabolic process
FOC45_RS10395	COG3340	Belongs to the peptidase S51 family
FOC45_RS10400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FOC45_RS10405	COG0300	oxidoreductase activity
FOC45_RS10435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FOC45_RS10475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FOC45_RS10480	COG1575	Belongs to the MenA family. Type 1 subfamily
FOC45_RS10500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOC45_RS10505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOC45_RS10510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FOC45_RS10525	COG0756	dUTP diphosphatase activity
FOC45_RS10540	COG3645	SOS response
FOC45_RS10545	COG3189	MarR family transcriptional regulator
FOC45_RS10550	COG0366	Alpha amylase catalytic
FOC45_RS10560	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FOC45_RS10565	COG1629	transport
FOC45_RS10565	COG4206	TonB-dependent receptor
FOC45_RS10570	COG1082	Xylose isomerase domain protein TIM barrel
FOC45_RS10575	COG0028	Belongs to the TPP enzyme family
FOC45_RS10615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FOC45_RS10620	COG0673	inositol 2-dehydrogenase activity
FOC45_RS10625	COG1234	tRNA 3'-trailer cleavage
FOC45_RS10645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FOC45_RS10655	COG1959	2 iron, 2 sulfur cluster binding
FOC45_RS10660	COG1960	acyl-CoA dehydrogenase activity
FOC45_RS10670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOC45_RS10685	COG3250	beta-galactosidase activity
FOC45_RS10705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FOC45_RS10710	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FOC45_RS10710	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FOC45_RS10755	COG0484	heat shock protein binding
FOC45_RS10765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FOC45_RS10780	COG3104	oligopeptide transport
FOC45_RS10785	COG1506	peptidase
FOC45_RS10785	COG0823	Involved in the tonB-independent uptake of proteins
FOC45_RS10790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FOC45_RS10800	COG2966	Psort location CytoplasmicMembrane, score
FOC45_RS10805	COG3537	Alpha-1,2-mannosidase
FOC45_RS10810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC45_RS10810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC45_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
FOC45_RS10835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOC45_RS10835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOC45_RS10860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FOC45_RS10860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FOC45_RS10925	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FOC45_RS10930	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FOC45_RS10940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FOC45_RS10955	COG0489	protein tyrosine kinase activity
FOC45_RS10960	COG1854	S-ribosylhomocysteine lyase activity
FOC45_RS10965	COG0006	proline dipeptidase activity
FOC45_RS11015	COG0501	Belongs to the peptidase M48B family
FOC45_RS11020	COG1704	LemA family
FOC45_RS11050	COG1091	dTDP-4-dehydrorhamnose reductase activity
FOC45_RS11085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FOC45_RS11115	COG0358	DNA primase activity
FOC45_RS11145	COG2003	Belongs to the UPF0758 family
FOC45_RS11175	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FOC45_RS11180	COG0151	Belongs to the GarS family
FOC45_RS11185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOC45_RS11195	COG0123	including yeast histone deacetylase and acetoin utilization protein
FOC45_RS11210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC45_RS11210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC45_RS11255	COG2137	regulation of response to DNA damage stimulus
FOC45_RS11285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FOC45_RS11290	COG3250	beta-galactosidase activity
FOC45_RS11305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FOC45_RS11315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FOC45_RS11320	COG0563	adenylate kinase activity
FOC45_RS11370	COG1027	Aspartate ammonia-lyase
FOC45_RS11385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FOC45_RS11390	COG0393	Putative heavy-metal-binding
FOC45_RS11400	COG0629	single-stranded DNA binding
FOC45_RS11410	COG2066	Belongs to the glutaminase family
FOC45_RS11415	COG2166	iron-sulfur cluster assembly
FOC45_RS11420	COG2151	metal-sulfur cluster biosynthetic enzyme
FOC45_RS11445	COG0438	transferase activity, transferring glycosyl groups
FOC45_RS11460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FOC45_RS11465	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FOC45_RS11470	COG3041	Addiction module toxin RelE StbE family
FOC45_RS11505	COG1216	Glycosyl transferase, family 2
FOC45_RS11515	COG0463	Glycosyl transferase, family 2
FOC45_RS11535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FOC45_RS11540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FOC45_RS11545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FOC45_RS11550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FOC45_RS11580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FOC45_RS11585	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FOC45_RS11590	COG0668	transmembrane transport
FOC45_RS11610	COG3878	Protein conserved in bacteria
FOC45_RS11615	COG3645	SOS response
FOC45_RS11625	COG1082	Xylose isomerase domain protein TIM barrel
FOC45_RS11640	COG0702	epimerase
FOC45_RS11645	COG4771	TonB-dependent receptor
FOC45_RS11680	COG0495	leucyl-tRNA aminoacylation
FOC45_RS11710	COG0557	exoribonuclease II activity
FOC45_RS11720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FOC45_RS11760	COG0778	Nitroreductase
FOC45_RS11775	COG4771	TonB-dependent receptor
FOC45_RS11795	COG0450	alkyl hydroperoxide reductase
FOC45_RS11860	COG0698	ribose 5-phosphate isomerase
FOC45_RS11865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FOC45_RS11885	COG0166	Belongs to the GPI family
FOC45_RS11900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FOC45_RS11915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins