locus-tag	class	description
CGC58_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CGC58_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CGC58_RS00015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CGC58_RS00020	COG0688	phosphatidylethanolamine metabolic process
CGC58_RS00025	COG0217	transcriptional regulatory protein
CGC58_RS00035	COG0010	Belongs to the arginase family
CGC58_RS00045	COG1217	gtp-binding protein TYPA
CGC58_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CGC58_RS00060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CGC58_RS00080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CGC58_RS00085	COG1051	belongs to the nudix hydrolase family
CGC58_RS00095	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CGC58_RS00130	COG1136	(ABC) transporter
CGC58_RS00130	COG0577	efflux transmembrane transporter activity
CGC58_RS00150	COG0436	Aminotransferase
CGC58_RS00165	COG3264	Mechanosensitive ion channel
CGC58_RS00165	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CGC58_RS00170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CGC58_RS00185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CGC58_RS00205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CGC58_RS00205	COG0116	Belongs to the methyltransferase superfamily
CGC58_RS00210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CGC58_RS00225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CGC58_RS00235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CGC58_RS00255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CGC58_RS00275	COG2986	histidine ammonia-lyase
CGC58_RS00280	COG2270	Major facilitator Superfamily
CGC58_RS00295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CGC58_RS00300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CGC58_RS00305	COG1192	Involved in chromosome partitioning
CGC58_RS00310	COG1475	DNA binding
CGC58_RS00325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CGC58_RS00330	COG0438	transferase activity, transferring glycosyl groups
CGC58_RS00355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CGC58_RS00365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CGC58_RS00370	COG1522	sequence-specific DNA binding
CGC58_RS00385	COG0598	Magnesium transport protein CorA
CGC58_RS00390	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CGC58_RS00405	COG0433	COG0433 Predicted ATPase
CGC58_RS00415	COG0671	phosphoesterase, PA-phosphatase related
CGC58_RS00425	COG0191	fructose-bisphosphate aldolase activity
CGC58_RS00435	COG0793	Belongs to the peptidase S41A family
CGC58_RS00445	COG2326	polyphosphate kinase activity
CGC58_RS00455	COG0658	competence protein
CGC58_RS00455	COG2333	competence protein COMEC
CGC58_RS00460	COG0791	NLP P60 protein
CGC58_RS00465	COG0542	response to heat
CGC58_RS00470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CGC58_RS00475	COG0463	Glycosyl transferase, family 2
CGC58_RS00495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CGC58_RS00500	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CGC58_RS00505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CGC58_RS00510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CGC58_RS00520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CGC58_RS00545	COG1428	Deoxynucleoside kinase
CGC58_RS00550	COG1522	sequence-specific DNA binding
CGC58_RS00565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CGC58_RS00590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CGC58_RS00595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CGC58_RS00605	COG0564	pseudouridine synthase activity
CGC58_RS00615	COG0501	Belongs to the peptidase M48B family
CGC58_RS00645	COG2183	response to ionizing radiation
CGC58_RS00665	COG1132	(ABC) transporter
CGC58_RS00675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CGC58_RS00685	COG1136	(ABC) transporter
CGC58_RS00695	COG1301	dicarboxylic acid transport
CGC58_RS00715	COG1346	cytolysis
CGC58_RS00725	COG0442	prolyl-tRNA aminoacylation
CGC58_RS00745	COG0427	acetyl-CoA hydrolase
CGC58_RS00755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CGC58_RS00755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CGC58_RS00770	COG0596	Alpha beta hydrolase
CGC58_RS00775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CGC58_RS00790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CGC58_RS00805	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CGC58_RS00810	COG0252	asparaginase activity
CGC58_RS00825	COG2356	endonuclease I
CGC58_RS00840	COG1022	Amp-dependent synthetase and ligase
CGC58_RS00845	COG0196	riboflavin kinase activity
CGC58_RS00850	COG0183	Belongs to the thiolase family
CGC58_RS00860	COG0336	Belongs to the RNA methyltransferase TrmD family
CGC58_RS00865	COG0776	regulation of translation
CGC58_RS00870	COG1082	Xylose isomerase domain protein TIM barrel
CGC58_RS00875	COG0488	(ABC) transporter
CGC58_RS00885	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CGC58_RS00890	COG1755	Isoprenylcysteine carboxyl methyltransferase
CGC58_RS00895	COG0280	phosphate acetyltransferase
CGC58_RS00895	COG0857	belongs to the CobB CobQ family
CGC58_RS00900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CGC58_RS00910	COG0471	metal ion transport
CGC58_RS00920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CGC58_RS00925	COG1295	ribonuclease BN
CGC58_RS00935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CGC58_RS00975	COG0628	permease
CGC58_RS00980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CGC58_RS00995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CGC58_RS00995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CGC58_RS01005	COG1695	Transcriptional regulator
CGC58_RS01045	COG0179	Fumarylacetoacetate (FAA) hydrolase
CGC58_RS01060	COG1704	LemA family
CGC58_RS01070	COG0488	(ABC) transporter
CGC58_RS01090	COG0482	sulfurtransferase activity
CGC58_RS01100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CGC58_RS01110	COG2234	aminopeptidase activity
CGC58_RS01120	COG1028	Short-chain dehydrogenase reductase Sdr
CGC58_RS01145	COG4152	abc transporter atp-binding protein
CGC58_RS01155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CGC58_RS01160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CGC58_RS01165	COG0617	tRNA 3'-terminal CCA addition
CGC58_RS01165	COG0517	IMP dehydrogenase activity
CGC58_RS01165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CGC58_RS01170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CGC58_RS01180	COG2095	MarC family integral membrane protein
CGC58_RS01190	COG0859	PFAM glycosyl transferase family 9
CGC58_RS01195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CGC58_RS01205	COG1528	Iron-storage protein
CGC58_RS01220	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CGC58_RS01300	COG4948	Mandelate Racemase Muconate Lactonizing
CGC58_RS01305	COG1185	polyribonucleotide nucleotidyltransferase activity
CGC58_RS01310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CGC58_RS01315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CGC58_RS01320	COG3263	regulation of cellular component size
CGC58_RS01325	COG2195	Cleaves the N-terminal amino acid of tripeptides
CGC58_RS01440	COG1131	(ABC) transporter
CGC58_RS01445	COG0793	Belongs to the peptidase S41A family
CGC58_RS01450	COG2177	Part of the ABC transporter FtsEX involved in
CGC58_RS01460	COG1968	undecaprenyl-diphosphatase activity
CGC58_RS01470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CGC58_RS01475	COG0194	GDP metabolic process
CGC58_RS01480	COG1561	YicC-like family, N-terminal region
CGC58_RS01490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CGC58_RS01495	COG0653	protein targeting
CGC58_RS01505	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CGC58_RS01545	COG0463	Glycosyl transferase, family 2
CGC58_RS01560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CGC58_RS01580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CGC58_RS01595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CGC58_RS01600	COG0805	protein transport
CGC58_RS01610	COG1137	ATPase activity
CGC58_RS01615	COG2264	protein methyltransferase activity
CGC58_RS01625	COG0592	DNA-directed DNA polymerase activity
CGC58_RS01630	COG0768	penicillin binding
CGC58_RS01640	COG1792	Involved in formation and maintenance of cell shape
CGC58_RS01645	COG1077	Cell shape determining protein MreB Mrl
CGC58_RS01650	COG2205	protein histidine kinase activity
CGC58_RS01650	COG0784	Response regulator, receiver
CGC58_RS01655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CGC58_RS01660	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CGC58_RS01665	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CGC58_RS01665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CGC58_RS01670	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CGC58_RS01685	COG3842	ATPase activity
CGC58_RS01695	COG1523	belongs to the glycosyl hydrolase 13 family
CGC58_RS01775	COG3341	Caulimovirus viroplasmin
CGC58_RS01775	COG0328	RNA-DNA hybrid ribonuclease activity
CGC58_RS01785	COG2217	Heavy metal translocating P-type atpase
CGC58_RS01790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CGC58_RS01815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CGC58_RS01830	COG1774	PSP1 C-terminal conserved region
CGC58_RS01845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CGC58_RS01875	COG0045	succinate-CoA ligase (ADP-forming) activity
CGC58_RS01895	COG0072	phenylalanine-tRNA ligase activity
CGC58_RS01895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CGC58_RS01900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CGC58_RS01900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CGC58_RS01915	COG1595	DNA-templated transcription, initiation
CGC58_RS01920	COG0753	catalase activity
CGC58_RS01925	COG0133	tryptophan synthase activity
CGC58_RS01965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CGC58_RS01980	COG0268	Binds directly to 16S ribosomal RNA
CGC58_RS01995	COG1090	epimerase
CGC58_RS02000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CGC58_RS02005	COG1160	GTP binding
CGC58_RS02010	COG3537	Alpha-1,2-mannosidase
CGC58_RS02020	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CGC58_RS02055	COG1166	arginine decarboxylase activity
CGC58_RS02060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CGC58_RS02065	COG1752	Esterase of the alpha-beta hydrolase superfamily
CGC58_RS02070	COG1760	l-serine dehydratase
CGC58_RS02075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CGC58_RS02085	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CGC58_RS02095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CGC58_RS02100	COG0673	inositol 2-dehydrogenase activity
CGC58_RS02105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CGC58_RS02110	COG0534	Mate efflux family protein
CGC58_RS02115	COG0363	glucosamine-6-phosphate deaminase activity
CGC58_RS02125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CGC58_RS02145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CGC58_RS02160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CGC58_RS02165	COG4974	Belongs to the 'phage' integrase family
CGC58_RS02170	COG2234	aminopeptidase activity
CGC58_RS02175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CGC58_RS02190	COG0606	chelatase, subunit chli
CGC58_RS02205	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CGC58_RS02215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CGC58_RS02225	COG1663	tetraacyldisaccharide 4'-kinase activity
CGC58_RS02250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CGC58_RS02260	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CGC58_RS02265	COG2076	Multidrug Resistance protein
CGC58_RS02275	COG1629	transport
CGC58_RS02275	COG4206	TonB-dependent receptor
CGC58_RS02300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CGC58_RS02310	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CGC58_RS02310	COG0321	lipoyl(octanoyl) transferase activity
CGC58_RS02345	COG0772	Belongs to the SEDS family
CGC58_RS02350	COG2204	response regulator
CGC58_RS02360	COG2204	response regulator
CGC58_RS02365	COG0519	Catalyzes the synthesis of GMP from XMP
CGC58_RS02365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CGC58_RS02375	COG0335	large ribosomal subunit rRNA binding
CGC58_RS02380	COG2176	DNA-directed DNA polymerase activity
CGC58_RS02425	COG0443	Heat shock 70 kDa protein
CGC58_RS02435	COG1705	Flagellar rod assembly protein muramidase FlgJ
CGC58_RS02435	COG3951	Flagellar rod assembly protein muramidase FlgJ
CGC58_RS02440	COG2890	protein-(glutamine-N5) methyltransferase activity
CGC58_RS02460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CGC58_RS02465	COG0569	domain protein
CGC58_RS02465	COG2985	domain, Protein
CGC58_RS02475	COG0167	dihydroorotate dehydrogenase activity
CGC58_RS02480	COG0488	(ABC) transporter
CGC58_RS02500	COG0514	ATP-dependent DNA helicase (RecQ)
CGC58_RS02505	COG0517	IMP dehydrogenase activity
CGC58_RS02505	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CGC58_RS02520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CGC58_RS02525	COG0181	hydroxymethylbilane synthase activity
CGC58_RS02530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CGC58_RS02540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CGC58_RS02550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CGC58_RS02570	COG3119	arylsulfatase activity
CGC58_RS02575	COG0714	Associated with various cellular activities
CGC58_RS02595	COG4771	TonB-dependent receptor
CGC58_RS02615	COG4771	TonB-dependent receptor
CGC58_RS02680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CGC58_RS02690	COG1983	PspC domain protein
CGC58_RS02725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CGC58_RS02730	COG0359	binds to the 23S rRNA
CGC58_RS02735	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CGC58_RS02740	COG0360	Binds together with S18 to 16S ribosomal RNA
CGC58_RS02750	COG0357	Ribosomal RNA small subunit methyltransferase G
CGC58_RS02775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CGC58_RS02780	COG0561	phosphatase activity
CGC58_RS02785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CGC58_RS02790	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CGC58_RS02800	COG0552	protein localization to endoplasmic reticulum
CGC58_RS02805	COG2356	endonuclease I
CGC58_RS02815	COG1333	cytochrome c biogenesis protein
CGC58_RS02815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CGC58_RS02840	COG0811	peptide transport
CGC58_RS02850	COG0252	asparaginase activity
CGC58_RS02860	COG0084	hydrolase, TatD family'
CGC58_RS02870	COG0248	Ppx GppA phosphatase
CGC58_RS02875	COG1803	Methylglyoxal synthase
CGC58_RS02885	COG0516	GMP reductase activity
CGC58_RS02885	COG0517	IMP dehydrogenase activity
CGC58_RS02925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CGC58_RS02935	COG2239	Acts as a magnesium transporter
CGC58_RS02940	COG0504	CTP synthase activity
CGC58_RS02945	COG0706	membrane insertase activity
CGC58_RS02995	COG4585	Histidine kinase
CGC58_RS03015	COG0138	bifunctional purine biosynthesis protein purh
CGC58_RS03030	COG2885	chlorophyll binding
CGC58_RS03045	COG0348	domain, Protein
CGC58_RS03060	COG3278	Belongs to the heme-copper respiratory oxidase family
CGC58_RS03070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CGC58_RS03075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CGC58_RS03085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CGC58_RS03090	COG4452	Inner membrane protein CreD
CGC58_RS03130	COG0556	nucleotide-excision repair
CGC58_RS03145	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CGC58_RS03160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CGC58_RS03170	COG0085	RNA polymerase activity
CGC58_RS03175	COG0222	ribosome binding
CGC58_RS03180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CGC58_RS03185	COG0081	regulation of translation
CGC58_RS03190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CGC58_RS03235	COG0366	Alpha amylase catalytic
CGC58_RS03260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CGC58_RS03265	COG3537	Alpha-1,2-mannosidase
CGC58_RS03275	COG2226	methyltransferase
CGC58_RS03290	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CGC58_RS03300	COG0424	maF-like protein
CGC58_RS03305	COG1480	7TM receptor with intracellular HD hydrolase
CGC58_RS03315	COG3059	membrane
CGC58_RS03330	COG0826	peptidase U32
CGC58_RS03370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CGC58_RS03375	COG1428	Deoxynucleoside kinase
CGC58_RS03390	COG0175	sulfate reduction
CGC58_RS03400	COG0175	sulfate reduction
CGC58_RS03435	COG0124	histidyl-tRNA synthetase
CGC58_RS03445	COG1187	pseudouridine synthase activity
CGC58_RS03450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CGC58_RS03460	COG0616	signal peptide processing
CGC58_RS03470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CGC58_RS03480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CGC58_RS03485	COG0423	glycine-tRNA ligase activity
CGC58_RS03490	COG1040	competence protein
CGC58_RS03505	COG0287	Prephenate dehydrogenase
CGC58_RS03510	COG0287	Prephenate dehydrogenase
CGC58_RS03510	COG1605	Chorismate mutase
CGC58_RS03515	COG0460	homoserine dehydrogenase
CGC58_RS03515	COG0527	aspartate kinase activity
CGC58_RS03530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CGC58_RS03540	COG0116	Belongs to the methyltransferase superfamily
CGC58_RS03550	COG3594	Acyltransferase
CGC58_RS03565	COG1082	Xylose isomerase domain protein TIM barrel
CGC58_RS03580	COG0629	single-stranded DNA binding
CGC58_RS03585	COG1194	a g-specific adenine glycosylase
CGC58_RS03590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CGC58_RS03600	COG1696	Membrane protein involved in D-alanine export
CGC58_RS03605	COG1388	LysM domain
CGC58_RS03605	COG0791	NLP P60 protein
CGC58_RS03615	COG1215	transferase activity, transferring glycosyl groups
CGC58_RS03620	COG0512	Glutamine amidotransferase of anthranilate synthase
CGC58_RS03635	COG2255	four-way junction helicase activity
CGC58_RS03645	COG0321	lipoyl(octanoyl) transferase activity
CGC58_RS03675	COG0612	Peptidase, M16
CGC58_RS03705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CGC58_RS03710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CGC58_RS03715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CGC58_RS03720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CGC58_RS03735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CGC58_RS03740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CGC58_RS03750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CGC58_RS03755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CGC58_RS03785	COG0259	pyridoxamine-phosphate oxidase activity
CGC58_RS03790	COG1234	tRNA 3'-trailer cleavage
CGC58_RS03805	COG0540	Belongs to the ATCase OTCase family
CGC58_RS03840	COG0673	inositol 2-dehydrogenase activity
CGC58_RS03855	COG1162	GTPase activity
CGC58_RS03865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CGC58_RS03890	COG1193	negative regulation of DNA recombination
CGC58_RS03895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CGC58_RS03905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CGC58_RS03930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CGC58_RS03940	COG5433	transposase activity
CGC58_RS03945	COG1074	ATP-dependent DNA helicase activity
CGC58_RS03950	COG0488	(ABC) transporter
CGC58_RS03960	COG1696	Membrane protein involved in D-alanine export
CGC58_RS03975	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CGC58_RS03985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CGC58_RS03990	COG3118	belongs to the thioredoxin family
CGC58_RS04000	COG0813	purine-nucleoside phosphorylase activity
CGC58_RS04015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CGC58_RS04025	COG1012	belongs to the aldehyde dehydrogenase family
CGC58_RS04030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CGC58_RS04050	COG1418	mRNA catabolic process
CGC58_RS04055	COG2081	HI0933 family
CGC58_RS04060	COG0633	Ferredoxin
CGC58_RS04070	COG0492	ferredoxin-NADP+ reductase activity
CGC58_RS04085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CGC58_RS04095	COG4717	serine-type aminopeptidase activity
CGC58_RS04105	COG1611	Belongs to the LOG family
CGC58_RS04115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CGC58_RS04120	COG0708	Exodeoxyribonuclease III
CGC58_RS04130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CGC58_RS04135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CGC58_RS04160	COG2223	nitrite transmembrane transporter activity
CGC58_RS04165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CGC58_RS04170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CGC58_RS04190	COG0018	arginyl-trna synthetase
CGC58_RS04205	COG0129	dihydroxy-acid dehydratase activity
CGC58_RS04225	COG0028	Belongs to the TPP enzyme family
CGC58_RS04230	COG0440	acetolactate synthase activity
CGC58_RS04235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CGC58_RS04240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CGC58_RS04255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CGC58_RS04265	COG5000	phosphorelay sensor kinase activity
CGC58_RS04275	COG0738	Major facilitator superfamily
CGC58_RS04280	COG0702	epimerase
CGC58_RS04285	COG4771	TonB-dependent receptor
CGC58_RS04295	COG1070	Carbohydrate kinase
CGC58_RS04300	COG0235	Class ii aldolase
CGC58_RS04305	COG1917	Cupin 2, conserved barrel domain protein
CGC58_RS04305	COG2207	Transcriptional regulator
CGC58_RS04320	COG0105	UTP biosynthetic process
CGC58_RS04325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CGC58_RS04335	COG0254	rRNA binding
CGC58_RS04355	COG0006	proline dipeptidase activity
CGC58_RS04360	COG1530	ribonuclease E activity
CGC58_RS04365	COG0776	regulation of translation
CGC58_RS04435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CGC58_RS04455	COG0668	transmembrane transport
CGC58_RS04460	COG5002	protein histidine kinase activity
CGC58_RS04465	COG0745	RESPONSE REGULATOR receiver
CGC58_RS04485	COG2885	chlorophyll binding
CGC58_RS04490	COG0156	8-amino-7-oxononanoate synthase activity
CGC58_RS04495	COG0470	DNA polymerase III
CGC58_RS04520	COG2197	response regulator
CGC58_RS04525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CGC58_RS04540	COG0471	metal ion transport
CGC58_RS04550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CGC58_RS04555	COG2244	polysaccharide biosynthetic process
CGC58_RS04565	COG1216	Glycosyl transferase, family 2
CGC58_RS04575	COG1215	transferase activity, transferring glycosyl groups
CGC58_RS04585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CGC58_RS04585	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CGC58_RS04610	COG1091	dTDP-4-dehydrorhamnose reductase activity
CGC58_RS04615	COG0346	lactoylglutathione lyase activity
CGC58_RS04645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CGC58_RS04690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CGC58_RS04690	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CGC58_RS04695	COG0686	Belongs to the AlaDH PNT family
CGC58_RS04710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CGC58_RS04715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CGC58_RS04720	COG1575	Belongs to the MenA family. Type 1 subfamily
CGC58_RS04725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CGC58_RS04740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CGC58_RS04745	COG0156	8-amino-7-oxononanoate synthase activity
CGC58_RS04750	COG0037	tRNA processing
CGC58_RS04755	COG0527	aspartate kinase activity
CGC58_RS04760	COG2363	Small membrane protein
CGC58_RS04790	COG0437	4 iron, 4 sulfur cluster binding
CGC58_RS04795	COG4654	Cytochrome c, class I
CGC58_RS04805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CGC58_RS04815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CGC58_RS04820	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CGC58_RS04835	COG2244	polysaccharide biosynthetic process
CGC58_RS04850	COG0463	Glycosyl transferase, family 2
CGC58_RS04850	COG1216	Glycosyl transferase, family 2
CGC58_RS04860	COG1216	Glycosyl transferase, family 2
CGC58_RS04880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CGC58_RS04885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CGC58_RS04890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CGC58_RS04900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CGC58_RS04920	COG0459	protein refolding
CGC58_RS04930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CGC58_RS04950	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CGC58_RS04955	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CGC58_RS04980	COG4771	TonB-dependent receptor
CGC58_RS05005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CGC58_RS05010	COG1214	PFAM Peptidase M22, glycoprotease
CGC58_RS05025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CGC58_RS05040	COG2731	YhcH YjgK YiaL family protein
CGC58_RS05225	COG4282	regulation of fungal-type cell wall biogenesis
CGC58_RS05440	COG1288	antiporter activity
CGC58_RS05455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CGC58_RS05475	COG0393	Putative heavy-metal-binding
CGC58_RS05480	COG0358	DNA primase activity
CGC58_RS05490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CGC58_RS05495	COG1854	S-ribosylhomocysteine lyase activity
CGC58_RS05520	COG3561	AntA/AntB antirepressor
CGC58_RS05535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CGC58_RS05540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CGC58_RS05550	COG3586	endonuclease activity
CGC58_RS05575	COG0495	leucyl-tRNA aminoacylation
CGC58_RS05640	COG0756	dUTP diphosphatase activity
CGC58_RS05660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CGC58_RS05700	COG3738	Protein conserved in bacteria
CGC58_RS05740	COG4771	TonB-dependent receptor
CGC58_RS05745	COG0702	epimerase
CGC58_RS05760	COG1472	Belongs to the glycosyl hydrolase 3 family
CGC58_RS05790	COG2274	protein secretion by the type I secretion system
CGC58_RS05820	COG4124	Belongs to the glycosyl hydrolase 26 family
CGC58_RS05825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CGC58_RS05835	COG1757	Na H antiporter
CGC58_RS05850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CGC58_RS05865	COG0492	ferredoxin-NADP+ reductase activity
CGC58_RS05895	COG0481	GTPase activity
CGC58_RS05905	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CGC58_RS05915	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CGC58_RS05920	COG0720	synthase
CGC58_RS05935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CGC58_RS05960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CGC58_RS05965	COG1505	serine-type exopeptidase activity
CGC58_RS05975	COG3842	ATPase activity
CGC58_RS05985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CGC58_RS06000	COG0861	Integral membrane protein TerC family
CGC58_RS06025	COG1554	hydrolase, family 65, central catalytic
CGC58_RS06045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CGC58_RS06055	COG0463	Glycosyl transferase, family 2
CGC58_RS06060	COG1215	transferase activity, transferring glycosyl groups
CGC58_RS06065	COG1216	Glycosyl transferase, family 2
CGC58_RS06065	COG1442	glycosyl transferase family 8
CGC58_RS06085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CGC58_RS06090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CGC58_RS06095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CGC58_RS06105	COG0288	reversible hydration of carbon dioxide
CGC58_RS06120	COG4804	nuclease activity
CGC58_RS06165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CGC58_RS06180	COG0450	alkyl hydroperoxide reductase
CGC58_RS06210	COG0750	zinc metalloprotease
CGC58_RS06215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CGC58_RS06220	COG3118	belongs to the thioredoxin family
CGC58_RS06225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CGC58_RS06325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CGC58_RS06330	COG0594	ribonuclease P activity
CGC58_RS06340	COG1629	transport
CGC58_RS06340	COG4206	TonB-dependent receptor
CGC58_RS06345	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CGC58_RS06375	COG3340	Belongs to the peptidase S51 family
CGC58_RS06395	COG3250	beta-galactosidase activity
CGC58_RS06410	COG4942	peptidase
CGC58_RS06420	COG0489	protein tyrosine kinase activity
CGC58_RS06430	COG2223	nitrite transmembrane transporter activity
CGC58_RS06440	COG2194	sulfuric ester hydrolase activity
CGC58_RS06490	COG0557	exoribonuclease II activity
CGC58_RS06495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CGC58_RS06535	COG4804	nuclease activity
CGC58_RS06540	COG0438	transferase activity, transferring glycosyl groups
CGC58_RS06575	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CGC58_RS06585	COG0126	phosphoglycerate kinase activity
CGC58_RS06590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CGC58_RS06610	COG4206	TonB-dependent receptor
CGC58_RS06610	COG1629	transport
CGC58_RS06620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CGC58_RS06625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CGC58_RS06640	COG3206	protein involved in exopolysaccharide biosynthesis
CGC58_RS06640	COG0489	protein tyrosine kinase activity
CGC58_RS06645	COG4206	TonB-dependent receptor
CGC58_RS06645	COG1629	transport
CGC58_RS06655	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CGC58_RS06665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CGC58_RS06685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CGC58_RS06705	COG0632	four-way junction helicase activity
CGC58_RS06710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CGC58_RS06710	COG0515	serine threonine protein kinase
CGC58_RS06720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CGC58_RS06740	COG2205	protein histidine kinase activity
CGC58_RS06740	COG3292	Two component regulator propeller
CGC58_RS06740	COG0745	RESPONSE REGULATOR receiver
CGC58_RS06745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CGC58_RS06765	COG0445	tRNA wobble uridine modification
CGC58_RS06775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CGC58_RS06785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CGC58_RS06835	COG1114	Component of the transport system for branched-chain amino acids
CGC58_RS06865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CGC58_RS06865	COG0617	tRNA 3'-terminal CCA addition
CGC58_RS06865	COG3620	sequence-specific DNA binding
CGC58_RS06905	COG4771	TonB-dependent receptor
CGC58_RS06935	COG4771	TonB-dependent receptor
CGC58_RS06940	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CGC58_RS06970	COG0469	pyruvate kinase activity
CGC58_RS06990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CGC58_RS06995	COG2373	Large extracellular alpha-helical protein
CGC58_RS07000	COG4771	TonB-dependent receptor
CGC58_RS07010	COG1629	transport
CGC58_RS07010	COG4206	TonB-dependent receptor
CGC58_RS07015	COG0322	excinuclease ABC activity
CGC58_RS07020	COG1131	(ABC) transporter
CGC58_RS07030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CGC58_RS07045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CGC58_RS07100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CGC58_RS07145	COG1490	D-aminoacyl-tRNA deacylase activity
CGC58_RS07165	COG0778	Nitroreductase
CGC58_RS07175	COG1629	transport
CGC58_RS07190	COG0823	Involved in the tonB-independent uptake of proteins
CGC58_RS07190	COG1506	peptidase
CGC58_RS07200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CGC58_RS07215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CGC58_RS07220	COG0151	Belongs to the GarS family
CGC58_RS07225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CGC58_RS07240	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CGC58_RS07245	COG1253	flavin adenine dinucleotide binding
CGC58_RS07280	COG0193	aminoacyl-tRNA hydrolase activity
CGC58_RS07325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CGC58_RS07330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CGC58_RS07335	COG1629	transport
CGC58_RS07345	COG4771	TonB-dependent receptor
CGC58_RS07375	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CGC58_RS07405	COG0509	glycine decarboxylation via glycine cleavage system
CGC58_RS07420	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CGC58_RS07430	COG1519	Transferase
CGC58_RS07565	COG3177	Filamentation induced by cAMP protein fic
CGC58_RS07610	COG0429	hydrolase of the alpha beta-hydrolase fold
CGC58_RS07615	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CGC58_RS07620	COG2824	Alkylphosphonate utilization operon protein PhnA
CGC58_RS07625	COG1999	signal sequence binding
CGC58_RS07635	COG0563	adenylate kinase activity
CGC58_RS07640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CGC58_RS07650	COG0571	ribonuclease III activity
CGC58_RS07655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CGC58_RS07660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CGC58_RS07665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CGC58_RS07680	COG4771	TonB-dependent receptor
CGC58_RS07695	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CGC58_RS07700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CGC58_RS07725	COG0825	malonyl-CoA metabolic process
CGC58_RS07735	COG0305	Participates in initiation and elongation during chromosome replication
CGC58_RS07740	COG0488	(ABC) transporter
CGC58_RS07745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CGC58_RS07770	COG0596	Alpha beta hydrolase
CGC58_RS07775	COG1950	PFAM Membrane protein of
CGC58_RS07785	COG0564	pseudouridine synthase activity
CGC58_RS07790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CGC58_RS07795	COG0628	permease
CGC58_RS07805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CGC58_RS07815	COG0300	oxidoreductase activity
CGC58_RS07825	COG5433	transposase activity
CGC58_RS07840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CGC58_RS07850	COG0356	it plays a direct role in the translocation of protons across the membrane
CGC58_RS07855	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CGC58_RS07860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CGC58_RS07865	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CGC58_RS07870	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CGC58_RS07875	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CGC58_RS07880	COG0047	phosphoribosylformylglycinamidine synthase activity
CGC58_RS07880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CGC58_RS07885	COG5433	transposase activity
CGC58_RS07900	COG0166	Belongs to the GPI family
CGC58_RS07935	COG3119	arylsulfatase activity
CGC58_RS07975	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CGC58_RS08000	COG2217	Heavy metal translocating P-type atpase
CGC58_RS08005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CGC58_RS08015	COG1446	asparaginase
CGC58_RS08020	COG1396	sequence-specific DNA binding
CGC58_RS08040	COG0113	porphobilinogen synthase activity
CGC58_RS08055	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CGC58_RS08075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CGC58_RS08090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CGC58_RS08100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CGC58_RS08105	COG0772	Belongs to the SEDS family
CGC58_RS08110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CGC58_RS08130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CGC58_RS08145	COG1943	Transposase
CGC58_RS08165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CGC58_RS08205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CGC58_RS08255	COG0275	rRNA processing
CGC58_RS08260	COG2001	Belongs to the MraZ family
CGC58_RS08265	COG1131	(ABC) transporter
CGC58_RS08275	COG1725	Transcriptional regulator
CGC58_RS08285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CGC58_RS08295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CGC58_RS08305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CGC58_RS08310	COG0242	peptide deformylase activity
CGC58_RS08320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CGC58_RS08335	COG0668	transmembrane transport
CGC58_RS08340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CGC58_RS08345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CGC58_RS08345	COG0758	DNA mediated transformation
CGC58_RS08365	COG2151	metal-sulfur cluster biosynthetic enzyme
CGC58_RS08370	COG2166	iron-sulfur cluster assembly
CGC58_RS08395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CGC58_RS08405	COG3655	Transcriptional regulator
CGC58_RS08420	COG2502	aspartate--ammonia ligase
CGC58_RS08425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CGC58_RS08430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CGC58_RS08435	COG0326	Molecular chaperone. Has ATPase activity
CGC58_RS08460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CGC58_RS08460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CGC58_RS08480	COG0779	Required for maturation of 30S ribosomal subunits
CGC58_RS08485	COG0195	Participates in both transcription termination and antitermination
CGC58_RS08485	COG2251	uridine kinase activity
CGC58_RS08490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CGC58_RS08495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CGC58_RS08555	COG3250	beta-galactosidase activity
CGC58_RS08585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CGC58_RS08595	COG2321	neutral zinc metallopeptidase
CGC58_RS08610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CGC58_RS08615	COG1702	phosphate starvation-inducible protein PhoH
CGC58_RS08645	COG0017	Asparaginyl-tRNA synthetase
CGC58_RS08650	COG1012	belongs to the aldehyde dehydrogenase family
CGC58_RS08655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CGC58_RS08665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CGC58_RS08670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CGC58_RS08675	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CGC58_RS08680	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CGC58_RS08685	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CGC58_RS08690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CGC58_RS08710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CGC58_RS08715	COG0049	tRNA binding
CGC58_RS08720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CGC58_RS08725	COG0051	transcription antitermination factor activity, RNA binding
CGC58_RS08730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CGC58_RS08735	COG0088	Forms part of the polypeptide exit tunnel
CGC58_RS08740	COG0089	rRNA binding
CGC58_RS08745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CGC58_RS08750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CGC58_RS08755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CGC58_RS08760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CGC58_RS08765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CGC58_RS08770	COG0255	Belongs to the universal ribosomal protein uL29 family
CGC58_RS08775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CGC58_RS08780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CGC58_RS08785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CGC58_RS08790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CGC58_RS08795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CGC58_RS08800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CGC58_RS08805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CGC58_RS08810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CGC58_RS08815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CGC58_RS08820	COG1841	ribosomal large subunit assembly
CGC58_RS08825	COG0200	Binds to the 23S rRNA
CGC58_RS08835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CGC58_RS08840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CGC58_RS08845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CGC58_RS08850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CGC58_RS08855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CGC58_RS08860	COG0202	RNA polymerase activity
CGC58_RS08865	COG0203	ribosomal protein L17
CGC58_RS08870	COG1757	Na H antiporter
CGC58_RS08900	COG3250	beta-galactosidase activity
CGC58_RS08920	COG2304	oxidoreductase activity
CGC58_RS08925	COG2304	oxidoreductase activity
CGC58_RS08955	COG0714	Associated with various cellular activities
CGC58_RS08960	COG1078	dGTPase activity
CGC58_RS08970	COG3250	beta-galactosidase activity
CGC58_RS08985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CGC58_RS08990	COG0596	Alpha beta hydrolase
CGC58_RS09000	COG2195	Cleaves the N-terminal amino acid of tripeptides
CGC58_RS09015	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CGC58_RS09025	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CGC58_RS09030	COG3876	Protein conserved in bacteria
CGC58_RS09045	COG1132	(ABC) transporter
CGC58_RS09050	COG0719	Fe-S assembly protein
CGC58_RS09075	COG0582	viral genome integration into host DNA
CGC58_RS09080	COG4974	Belongs to the 'phage' integrase family
CGC58_RS09105	COG1846	Transcriptional regulator
CGC58_RS09150	COG0396	ATPase activity
CGC58_RS09170	COG0719	Fe-S assembly protein
CGC58_RS09180	COG0316	Belongs to the HesB IscA family
CGC58_RS09190	COG0508	dehydrogenase complex catalyzes the overall conversion of
CGC58_RS09210	COG0567	Dehydrogenase, E1 component
CGC58_RS09225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CGC58_RS09235	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CGC58_RS09240	COG4771	TonB-dependent receptor
CGC58_RS09245	COG0702	epimerase
CGC58_RS09250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CGC58_RS09300	COG0284	orotidine-5'-phosphate decarboxylase activity
CGC58_RS09305	COG0302	gtp cyclohydrolase
CGC58_RS09315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CGC58_RS09325	COG4206	TonB-dependent receptor
CGC58_RS09325	COG1629	transport
CGC58_RS09335	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CGC58_RS09340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CGC58_RS09340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CGC58_RS09345	COG1739	Uncharacterized protein family UPF0029
CGC58_RS09360	COG1136	(ABC) transporter
CGC58_RS09365	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CGC58_RS09385	COG0148	phosphopyruvate hydratase activity
CGC58_RS09390	COG0505	Belongs to the CarA family
CGC58_RS09395	COG3119	arylsulfatase activity
CGC58_RS09405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CGC58_RS09415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CGC58_RS09420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CGC58_RS09425	COG0052	Belongs to the universal ribosomal protein uS2 family
CGC58_RS09430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CGC58_RS09445	COG1335	isochorismatase
CGC58_RS09450	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CGC58_RS09455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CGC58_RS09460	COG3104	oligopeptide transport
CGC58_RS09480	COG1506	peptidase
CGC58_RS09480	COG0823	Involved in the tonB-independent uptake of proteins
CGC58_RS09485	COG0149	triose-phosphate isomerase activity
CGC58_RS09490	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CGC58_RS09500	COG1595	DNA-templated transcription, initiation
CGC58_RS09510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CGC58_RS09515	COG0386	Belongs to the glutathione peroxidase family
CGC58_RS09545	COG3561	AntA/AntB antirepressor
CGC58_RS09565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CGC58_RS09570	COG0508	dehydrogenase complex catalyzes the overall conversion of
CGC58_RS09575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CGC58_RS09620	COG0339	signal peptide processing
CGC58_RS09630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CGC58_RS09645	COG0215	cysteine-tRNA ligase activity
CGC58_RS09660	COG1053	succinate dehydrogenase
CGC58_RS09675	COG2706	6-phosphogluconolactonase activity
CGC58_RS09680	COG4771	TonB-dependent receptor
CGC58_RS09760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CGC58_RS09765	COG3022	response to hydroperoxide
CGC58_RS09780	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CGC58_RS09785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CGC58_RS09825	COG4977	sequence-specific DNA binding
CGC58_RS09825	COG1917	Cupin 2, conserved barrel domain protein
CGC58_RS09855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CGC58_RS09860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CGC58_RS09865	COG2022	thiamine diphosphate biosynthetic process
CGC58_RS09870	COG0352	thiamine-phosphate diphosphorylase activity
CGC58_RS09875	COG0351	phosphomethylpyrimidine kinase
CGC58_RS09880	COG0352	thiamine-phosphate diphosphorylase activity
CGC58_RS09885	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CGC58_RS09920	COG1917	Cupin 2, conserved barrel domain protein
CGC58_RS09920	COG4977	sequence-specific DNA binding
CGC58_RS09955	COG1733	regulation of RNA biosynthetic process
CGC58_RS10030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CGC58_RS10035	COG1230	cation diffusion facilitator family transporter
CGC58_RS10135	COG1621	beta-fructofuranosidase activity
CGC58_RS10140	COG0702	epimerase
CGC58_RS10145	COG1629	transport
CGC58_RS10155	COG0745	RESPONSE REGULATOR receiver
CGC58_RS10155	COG2205	protein histidine kinase activity
CGC58_RS10155	COG3292	Two component regulator propeller
CGC58_RS10170	COG4974	Belongs to the 'phage' integrase family
CGC58_RS10185	COG2249	NAD(P)H dehydrogenase (quinone) activity
CGC58_RS10190	COG0799	negative regulation of ribosome biogenesis
CGC58_RS10195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CGC58_RS10205	COG4589	Belongs to the CDS family
CGC58_RS10210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CGC58_RS10220	COG0840	transmembrane signaling receptor activity
CGC58_RS10225	COG0840	transmembrane signaling receptor activity
CGC58_RS10230	COG1250	3-hydroxyacyl-CoA dehydrogenase
CGC58_RS10230	COG1024	Enoyl-CoA hydratase
CGC58_RS10235	COG0295	cytidine deaminase activity
CGC58_RS10245	COG1408	metallophosphoesterase
CGC58_RS10250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CGC58_RS10260	COG0737	Belongs to the 5'-nucleotidase family
CGC58_RS10265	COG0737	Belongs to the 5'-nucleotidase family
CGC58_RS10290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CGC58_RS10290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CGC58_RS10295	COG0187	DNA topoisomerase II activity
CGC58_RS10305	COG0508	dehydrogenase complex catalyzes the overall conversion of
CGC58_RS10305	COG0022	dehydrogenase e1 component
CGC58_RS10310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CGC58_RS10335	COG0525	valine-tRNA ligase activity
CGC58_RS10355	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CGC58_RS10380	COG0237	dephospho-CoA kinase activity
CGC58_RS10410	COG2860	membrane
CGC58_RS10430	COG4771	TonB-dependent receptor
CGC58_RS10460	COG2181	nitrate reductase activity
CGC58_RS10460	COG0247	lactate metabolic process
CGC58_RS10465	COG0247	lactate metabolic process
CGC58_RS10465	COG2181	nitrate reductase activity
CGC58_RS10475	COG0860	N-Acetylmuramoyl-L-alanine amidase
CGC58_RS10490	COG0463	Glycosyl transferase, family 2
CGC58_RS10505	COG2226	methyltransferase
CGC58_RS10515	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CGC58_RS10525	COG0494	nUDIX hydrolase
CGC58_RS10530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CGC58_RS10585	COG0827	DNA restriction-modification system
CGC58_RS10665	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CGC58_RS10670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CGC58_RS10670	COG0463	Glycosyl transferase, family 2
CGC58_RS10675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CGC58_RS10680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CGC58_RS10715	COG2843	Capsule synthesis protein
CGC58_RS10745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CGC58_RS10750	COG0542	response to heat
CGC58_RS10755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CGC58_RS10770	COG0156	8-amino-7-oxononanoate synthase activity
CGC58_RS10795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CGC58_RS10810	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CGC58_RS10815	COG1690	Belongs to the RtcB family
CGC58_RS10835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CGC58_RS10845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CGC58_RS10865	COG0009	L-threonylcarbamoyladenylate synthase
CGC58_RS10875	COG0544	peptidyl-prolyl cis-trans isomerase activity
CGC58_RS10880	COG0740	serine-type endopeptidase activity
CGC58_RS10885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CGC58_RS10890	COG1482	cell wall glycoprotein biosynthetic process
CGC58_RS10895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CGC58_RS10925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CGC58_RS10930	COG0569	domain protein
CGC58_RS10935	COG4206	TonB-dependent receptor
CGC58_RS10935	COG1629	transport
CGC58_RS10940	COG2827	Endonuclease containing a URI domain
CGC58_RS11000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CGC58_RS11005	COG0511	ligase activity, forming carbon-carbon bonds
CGC58_RS11010	COG0439	Biotin carboxylase
CGC58_RS11040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CGC58_RS11045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CGC58_RS11050	COG0019	diaminopimelate decarboxylase activity
CGC58_RS11055	COG2268	Band 7 protein
CGC58_RS11075	COG1104	cysteine desulfurase activity
CGC58_RS11085	COG0205	6-phosphofructokinase activity
CGC58_RS11090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CGC58_RS11100	COG3103	Sh3 type 3 domain protein
CGC58_RS11100	COG1388	LysM domain
CGC58_RS11100	COG0791	NLP P60 protein
CGC58_RS11105	COG1393	Belongs to the ArsC family
CGC58_RS11115	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CGC58_RS11120	COG0561	phosphatase activity
CGC58_RS11150	COG0686	Belongs to the AlaDH PNT family
CGC58_RS11160	COG0514	ATP-dependent DNA helicase (RecQ)
CGC58_RS11170	COG0285	dihydrofolate synthase activity
CGC58_RS11180	COG0848	biopolymer transport protein
CGC58_RS11185	COG0811	peptide transport
CGC58_RS11190	COG1132	(ABC) transporter
CGC58_RS11195	COG0588	phosphoglycerate mutase activity
CGC58_RS11205	COG3591	Belongs to the peptidase S1B family
CGC58_RS11210	COG2304	oxidoreductase activity
CGC58_RS11225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CGC58_RS11255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CGC58_RS11265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CGC58_RS11270	COG0228	four-way junction DNA binding
CGC58_RS11275	COG3852	Histidine kinase
CGC58_RS11280	COG2204	response regulator
CGC58_RS11290	COG1271	oxidase subunit
CGC58_RS11295	COG1294	oxidase, subunit
CGC58_RS11300	COG0339	signal peptide processing
CGC58_RS11305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CGC58_RS11315	COG3956	TIGRFAM MazG family protein
CGC58_RS11325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CGC58_RS11330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CGC58_RS11350	COG0297	glycogen (starch) synthase activity
CGC58_RS11355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CGC58_RS11360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CGC58_RS11375	COG1022	Amp-dependent synthetase and ligase
CGC58_RS11385	COG1960	acyl-CoA dehydrogenase activity
CGC58_RS11410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CGC58_RS11425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CGC58_RS11680	COG0542	response to heat
CGC58_RS11765	COG0629	single-stranded DNA binding
CGC58_RS11780	COG4974	Belongs to the 'phage' integrase family
CGC58_RS11790	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CGC58_RS11795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CGC58_RS11795	COG0515	serine threonine protein kinase
CGC58_RS11820	COG1805	sodium ion transport
CGC58_RS11825	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CGC58_RS11830	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CGC58_RS11835	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CGC58_RS11855	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CGC58_RS11860	COG1381	Involved in DNA repair and RecF pathway recombination
CGC58_RS11875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CGC58_RS11880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CGC58_RS11885	COG1970	mechanosensitive ion channel activity
CGC58_RS11890	COG0484	heat shock protein binding
CGC58_RS11905	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CGC58_RS11920	COG1674	ftsk spoiiie
CGC58_RS11925	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CGC58_RS11930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CGC58_RS11935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CGC58_RS11940	COG1862	Preprotein translocase
CGC58_RS11945	COG0792	nuclease activity
CGC58_RS11955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CGC58_RS11955	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CGC58_RS11960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CGC58_RS11970	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CGC58_RS11975	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CGC58_RS11985	COG0681	Belongs to the peptidase S26 family
CGC58_RS11995	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CGC58_RS12000	COG2884	Cell division ATP-binding protein ftsE
CGC58_RS12025	COG0251	oxidation-reduction process
CGC58_RS12030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CGC58_RS12035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CGC58_RS12050	COG0528	UMP kinase activity
CGC58_RS12055	COG0233	cytoplasmic translational termination
CGC58_RS12060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CGC58_RS12070	COG3005	denitrification pathway
CGC58_RS12075	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CGC58_RS12085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CGC58_RS12095	COG1960	acyl-CoA dehydrogenase activity
CGC58_RS12100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CGC58_RS12105	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CGC58_RS12115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CGC58_RS12130	COG0840	transmembrane signaling receptor activity
CGC58_RS12145	COG0783	Belongs to the Dps family
CGC58_RS12160	COG0343	queuine tRNA-ribosyltransferase activity
CGC58_RS12170	COG0602	queuosine metabolic process
CGC58_RS12175	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CGC58_RS12195	COG5434	Belongs to the glycosyl hydrolase 28 family
CGC58_RS12215	COG2050	protein possibly involved in aromatic compounds catabolism
CGC58_RS12225	COG0497	DNA recombination
CGC58_RS12235	COG5002	protein histidine kinase activity
CGC58_RS12240	COG0745	RESPONSE REGULATOR receiver
CGC58_RS12245	COG3119	arylsulfatase activity
CGC58_RS12255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CGC58_RS12280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CGC58_RS12285	COG0490	domain, Protein
CGC58_RS12285	COG0471	metal ion transport
CGC58_RS12290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CGC58_RS12295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CGC58_RS12300	COG0484	heat shock protein binding
CGC58_RS12315	COG0501	Belongs to the peptidase M48B family
CGC58_RS12320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CGC58_RS12325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CGC58_RS12330	COG0673	inositol 2-dehydrogenase activity
CGC58_RS12335	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CGC58_RS12335	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CGC58_RS12345	COG1396	sequence-specific DNA binding
CGC58_RS12350	COG1252	NADH dehydrogenase
CGC58_RS12355	COG2733	membrane
CGC58_RS12360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CGC58_RS12365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CGC58_RS12370	COG1181	Belongs to the D-alanine--D-alanine ligase family
CGC58_RS12375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CGC58_RS12430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CGC58_RS12435	COG1349	DNA-binding transcription factor activity
CGC58_RS12440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CGC58_RS12450	COG3340	Belongs to the peptidase S51 family
CGC58_RS12480	COG0009	L-threonylcarbamoyladenylate synthase
CGC58_RS12495	COG3119	arylsulfatase activity
CGC58_RS12505	COG0823	Involved in the tonB-independent uptake of proteins
CGC58_RS12505	COG1506	peptidase
CGC58_RS12545	COG0802	atpase or kinase
CGC58_RS12550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CGC58_RS12560	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CGC58_RS12565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CGC58_RS12585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CGC58_RS12590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CGC58_RS12595	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CGC58_RS12605	COG0824	Thioesterase