locus-tag	class	description
CAR_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CAR_RS00010	COG0592	DNA-directed DNA polymerase activity
CAR_RS00015	COG2501	S4 domain
CAR_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CAR_RS00025	COG0187	DNA topoisomerase II activity
CAR_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
CAR_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CAR_RS00055	COG0359	binds to the 23S rRNA
CAR_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
CAR_RS00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CAR_RS00080	COG2155	Conserved Protein
CAR_RS00095	COG0351	phosphomethylpyrimidine kinase
CAR_RS00105	COG4980	gas vesicle protein
CAR_RS00115	COG2190	(PTS) system
CAR_RS00120	COG0745	RESPONSE REGULATOR receiver
CAR_RS00125	COG5002	protein histidine kinase activity
CAR_RS00130	COG4863	YycH protein
CAR_RS00135	COG4853	Protein conserved in bacteria
CAR_RS00140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CAR_RS00145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAR_RS00160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CAR_RS00180	COG0625	glutathione transferase activity
CAR_RS00190	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAR_RS00195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAR_RS00205	COG0596	Alpha beta hydrolase
CAR_RS00210	COG1584	GPR1 FUN34 yaaH family protein
CAR_RS00220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAR_RS00240	COG3835	regulator
CAR_RS00245	COG1301	dicarboxylic acid transport
CAR_RS00270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CAR_RS00280	COG2233	PERMEase
CAR_RS00290	COG4807	Protein conserved in bacteria
CAR_RS00315	COG0791	NLP P60 protein
CAR_RS00320	COG4166	transmembrane transport
CAR_RS00335	COG1131	(ABC) transporter
CAR_RS00340	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CAR_RS00345	COG3576	pyridoxamine 5-phosphate
CAR_RS00395	COG1476	TRANSCRIPTIONal
CAR_RS00485	COG1136	(ABC) transporter
CAR_RS00490	COG1136	(ABC) transporter
CAR_RS00490	COG0577	efflux transmembrane transporter activity
CAR_RS00495	COG0582	viral genome integration into host DNA
CAR_RS00500	COG1051	belongs to the nudix hydrolase family
CAR_RS00550	COG2217	Heavy metal translocating P-type atpase
CAR_RS00560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CAR_RS00575	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CAR_RS00580	COG1461	Dihydroxyacetone kinase
CAR_RS00585	COG2376	Dihydroxyacetone kinase
CAR_RS00595	COG2249	NAD(P)H dehydrogenase (quinone) activity
CAR_RS00605	COG0488	(ABC) transporter
CAR_RS00615	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CAR_RS00620	COG0516	GMP reductase activity
CAR_RS00625	COG0702	epimerase
CAR_RS00630	COG1063	alcohol dehydrogenase
CAR_RS00650	COG0456	acetyltransferase
CAR_RS00670	COG0024	Methionine aminopeptidase
CAR_RS00675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS00675	COG2190	(PTS) system
CAR_RS00675	COG1263	PTS System
CAR_RS00680	COG2723	6-phospho-beta-galactosidase activity
CAR_RS00695	COG1215	transferase activity, transferring glycosyl groups
CAR_RS00700	COG1846	Transcriptional regulator
CAR_RS00705	COG0778	Nitroreductase
CAR_RS00755	COG0659	secondary active sulfate transmembrane transporter activity
CAR_RS00790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAR_RS00795	COG1733	regulation of RNA biosynthetic process
CAR_RS00815	COG0628	permease
CAR_RS00850	COG2610	gluconate transmembrane transporter activity
CAR_RS00855	COG1929	Belongs to the glycerate kinase type-1 family
CAR_RS00860	COG3835	regulator
CAR_RS00870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAR_RS00875	COG1126	abc transporter atp-binding protein
CAR_RS00880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAR_RS00885	COG0765	amino acid transport
CAR_RS00890	COG0765	amino acid transport
CAR_RS00895	COG1801	Protein of unknown function DUF72
CAR_RS00900	COG0561	phosphatase activity
CAR_RS00905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAR_RS00905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAR_RS00910	COG0084	hydrolase, TatD family'
CAR_RS00920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAR_RS00925	COG4466	Protein conserved in bacteria
CAR_RS00930	COG0346	lactoylglutathione lyase activity
CAR_RS00935	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CAR_RS00940	COG0803	Belongs to the bacterial solute-binding protein 9 family
CAR_RS00945	COG1121	(ABC) transporter
CAR_RS00950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAR_RS00955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CAR_RS00960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CAR_RS00965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAR_RS00975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAR_RS00980	COG0039	L-malate dehydrogenase activity
CAR_RS00985	COG0193	aminoacyl-tRNA hydrolase activity
CAR_RS00990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CAR_RS00995	COG2244	polysaccharide biosynthetic process
CAR_RS01000	COG3956	TIGRFAM MazG family protein
CAR_RS01005	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CAR_RS01015	COG1098	S1 RNA binding domain
CAR_RS01020	COG0037	tRNA processing
CAR_RS01035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CAR_RS01040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CAR_RS01045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CAR_RS01050	COG0628	permease
CAR_RS01070	COG3711	transcriptional antiterminator
CAR_RS01075	COG2190	(PTS) system
CAR_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS01075	COG1263	PTS System
CAR_RS01080	COG2723	6-phospho-beta-galactosidase activity
CAR_RS01160	COG4463	regulation of RNA biosynthetic process
CAR_RS01165	COG0542	response to heat
CAR_RS01175	COG2508	Transcriptional regulator
CAR_RS01180	COG0590	tRNA wobble adenosine to inosine editing
CAR_RS01185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CAR_RS01195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CAR_RS01200	COG1328	CTP reductase activity
CAR_RS01210	COG4895	conserved protein (DUF2196)
CAR_RS01215	COG1268	BioY protein
CAR_RS01225	COG0577	efflux transmembrane transporter activity
CAR_RS01225	COG1136	(ABC) transporter
CAR_RS01230	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CAR_RS01230	COG0456	acetyltransferase
CAR_RS01235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAR_RS01245	COG1649	PFAM Uncharacterised BCR, COG1649
CAR_RS01245	COG0726	polysaccharide deacetylase
CAR_RS01255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAR_RS01265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CAR_RS01270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CAR_RS01275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CAR_RS01285	COG1982	Orn Lys Arg decarboxylase major
CAR_RS01290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CAR_RS01295	COG3870	Protein conserved in bacteria
CAR_RS01300	COG0470	DNA polymerase III
CAR_RS01305	COG4467	Involved in initiation control of chromosome replication
CAR_RS01315	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CAR_RS01320	COG2827	Endonuclease containing a URI domain
CAR_RS01325	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CAR_RS01340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAR_RS01345	COG1027	Aspartate ammonia-lyase
CAR_RS01350	COG1522	sequence-specific DNA binding
CAR_RS01355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CAR_RS01360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CAR_RS01370	COG0693	protein deglycase activity
CAR_RS01375	COG1803	Methylglyoxal synthase
CAR_RS01380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAR_RS01385	COG1473	amidohydrolase
CAR_RS01390	COG1464	Belongs to the NlpA lipoprotein family
CAR_RS01395	COG2011	ABC-type metal ion transport system permease component
CAR_RS01400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAR_RS01405	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CAR_RS01415	COG1764	response to oxidative stress
CAR_RS01420	COG1942	4-Oxalocrotonate Tautomerase
CAR_RS01445	COG0395	ABC-type sugar transport system, permease component
CAR_RS01455	COG3507	Belongs to the glycosyl hydrolase 43 family
CAR_RS01460	COG3940	Belongs to the glycosyl hydrolase 43 family
CAR_RS01465	COG3534	alpha-L-arabinofuranosidase
CAR_RS01475	COG0235	Class ii aldolase
CAR_RS01480	COG2160	L-arabinose isomerase activity
CAR_RS01485	COG1609	Transcriptional regulator
CAR_RS01490	COG0561	phosphatase activity
CAR_RS01495	COG1078	dGTPase activity
CAR_RS01500	COG0095	Lipoate-protein ligase
CAR_RS01510	COG3343	RNA polymerase activity
CAR_RS01515	COG0504	CTP synthase activity
CAR_RS01525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAR_RS01530	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CAR_RS01535	COG0254	rRNA binding
CAR_RS01545	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAR_RS01550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CAR_RS01555	COG0670	Belongs to the BI1 family
CAR_RS01565	COG0736	holo-[acyl-carrier-protein] synthase activity
CAR_RS01575	COG2337	Toxic component of a toxin-antitoxin (TA) module
CAR_RS01580	COG4708	membrane
CAR_RS01625	COG0604	alcohol dehydrogenase
CAR_RS01630	COG2388	GCN5-related N-acetyl-transferase
CAR_RS01670	COG4856	YbbR-like protein
CAR_RS01675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAR_RS01685	COG1757	Na H antiporter
CAR_RS01695	COG2738	Putative neutral zinc metallopeptidase
CAR_RS01715	COG0577	efflux transmembrane transporter activity
CAR_RS01720	COG1136	(ABC) transporter
CAR_RS01735	COG0517	IMP dehydrogenase activity
CAR_RS01735	COG1125	glycine betaine transport
CAR_RS01740	COG1174	glycine betaine transport
CAR_RS01750	COG2183	response to ionizing radiation
CAR_RS01760	COG5434	Belongs to the glycosyl hydrolase 28 family
CAR_RS01765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CAR_RS01775	COG0463	Glycosyl transferase, family 2
CAR_RS01780	COG1368	sulfuric ester hydrolase activity
CAR_RS01790	COG0363	glucosamine-6-phosphate deaminase activity
CAR_RS01795	COG2188	Transcriptional regulator
CAR_RS01800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAR_RS01805	COG1316	TRANSCRIPTIONal
CAR_RS01810	COG1739	Uncharacterized protein family UPF0029
CAR_RS01815	COG1307	EDD domain protein, DegV family
CAR_RS01820	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CAR_RS01835	COG0653	protein targeting
CAR_RS01840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CAR_RS01845	COG2884	Cell division ATP-binding protein ftsE
CAR_RS01850	COG2177	Part of the ABC transporter FtsEX involved in
CAR_RS01855	COG3103	Sh3 type 3 domain protein
CAR_RS01855	COG0791	NLP P60 protein
CAR_RS01855	COG1388	LysM domain
CAR_RS01860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAR_RS01865	COG0745	RESPONSE REGULATOR receiver
CAR_RS01870	COG5002	protein histidine kinase activity
CAR_RS01875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CAR_RS01885	COG0581	inorganic phosphate transmembrane transporter activity
CAR_RS01890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAR_RS01895	COG0704	Plays a role in the regulation of phosphate uptake
CAR_RS01900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CAR_RS01905	COG0573	inorganic phosphate transmembrane transporter activity
CAR_RS01910	COG0581	inorganic phosphate transmembrane transporter activity
CAR_RS01915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAR_RS01920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAR_RS01925	COG0704	Plays a role in the regulation of phosphate uptake
CAR_RS01935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAR_RS01945	COG1983	PspC domain protein
CAR_RS01950	COG1950	PFAM Membrane protein of
CAR_RS01960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAR_RS01965	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAR_RS01970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CAR_RS01980	COG0492	ferredoxin-NADP+ reductase activity
CAR_RS01985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAR_RS01990	COG1660	Displays ATPase and GTPase activities
CAR_RS02000	COG1481	regulation of sporulation
CAR_RS02010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CAR_RS02015	COG0740	serine-type endopeptidase activity
CAR_RS02025	COG2390	Transcriptional regulator
CAR_RS02035	COG0126	phosphoglycerate kinase activity
CAR_RS02045	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CAR_RS02055	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CAR_RS02055	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CAR_RS02060	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS02060	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS02065	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CAR_RS02070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAR_RS02080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CAR_RS02090	COG0557	exoribonuclease II activity
CAR_RS02095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CAR_RS02100	COG0386	Belongs to the glutathione peroxidase family
CAR_RS02105	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CAR_RS02110	COG0588	phosphoglycerate mutase activity
CAR_RS02115	COG0561	phosphatase activity
CAR_RS02120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CAR_RS02125	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CAR_RS02130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAR_RS02135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAR_RS02140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CAR_RS02160	COG1295	ribonuclease BN
CAR_RS02165	COG0772	Belongs to the SEDS family
CAR_RS02170	COG1393	Belongs to the ArsC family
CAR_RS02175	COG0509	glycine decarboxylation via glycine cleavage system
CAR_RS02180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAR_RS02185	COG2011	ABC-type metal ion transport system permease component
CAR_RS02190	COG1464	Belongs to the NlpA lipoprotein family
CAR_RS02195	COG1609	Transcriptional regulator
CAR_RS02200	COG1486	melibiose metabolic process
CAR_RS02205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CAR_RS02210	COG3402	PFAM membrane-flanked domain
CAR_RS02225	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CAR_RS02235	COG0719	Fe-S assembly protein
CAR_RS02240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAR_RS02245	COG0822	iron-sulfur transferase activity
CAR_RS02250	COG0719	Fe-S assembly protein
CAR_RS02265	COG0513	Belongs to the DEAD box helicase family
CAR_RS02275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAR_RS02280	COG1120	ATPase activity
CAR_RS02295	COG1132	(ABC) transporter
CAR_RS02300	COG1132	(ABC) transporter
CAR_RS02305	COG0789	Transcriptional regulator
CAR_RS02310	COG1024	Enoyl-CoA hydratase
CAR_RS02325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CAR_RS02325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CAR_RS02335	COG0546	phosphoglycolate phosphatase activity
CAR_RS02345	COG0402	S-adenosylhomocysteine deaminase activity
CAR_RS02350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CAR_RS02380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAR_RS02385	COG0765	amino acid transport
CAR_RS02390	COG1126	abc transporter atp-binding protein
CAR_RS02405	COG3842	ATPase activity
CAR_RS02415	COG0395	ABC-type sugar transport system, permease component
CAR_RS02430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CAR_RS02435	COG4166	transmembrane transport
CAR_RS02450	COG1131	(ABC) transporter
CAR_RS02455	COG3559	Exporter of polyketide antibiotics
CAR_RS02475	COG3626	phosphonate metabolism
CAR_RS02480	COG3627	carbon phosphorus lyase activity
CAR_RS02485	COG4107	phosphonate C-P lyase system protein PhnK
CAR_RS02490	COG3454	Phosphonate metabolism
CAR_RS02500	COG4778	phosphonate C-P lyase system protein PhnL
CAR_RS02505	COG0613	PHP domain protein
CAR_RS02515	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CAR_RS02535	COG4166	transmembrane transport
CAR_RS02555	COG3715	PTS system
CAR_RS02560	COG3716	PTS system mannose fructose sorbose family IID component
CAR_RS02570	COG0693	protein deglycase activity
CAR_RS02580	COG1131	(ABC) transporter
CAR_RS02605	COG0656	L-ascorbic acid biosynthetic process
CAR_RS02625	COG0765	amino acid transport
CAR_RS02630	COG0765	amino acid transport
CAR_RS02635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAR_RS02645	COG0737	Belongs to the 5'-nucleotidase family
CAR_RS02650	COG4470	Protein conserved in bacteria
CAR_RS02655	COG0647	UMP catabolic process
CAR_RS02665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CAR_RS02670	COG0492	ferredoxin-NADP+ reductase activity
CAR_RS02675	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CAR_RS02680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAR_RS02690	COG1098	S1 RNA binding domain
CAR_RS02700	COG0166	Belongs to the GPI family
CAR_RS02820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CAR_RS02825	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CAR_RS02830	COG0671	phosphoesterase, PA-phosphatase related
CAR_RS02835	COG1705	Flagellar rod assembly protein muramidase FlgJ
CAR_RS02835	COG1388	LysM domain
CAR_RS02840	COG0495	leucyl-tRNA aminoacylation
CAR_RS02845	COG2244	polysaccharide biosynthetic process
CAR_RS02850	COG1187	pseudouridine synthase activity
CAR_RS02860	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CAR_RS02865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAR_RS02870	COG1794	racemase activity, acting on amino acids and derivatives
CAR_RS02885	COG1216	Glycosyl transferase, family 2
CAR_RS02885	COG1442	glycosyl transferase family 8
CAR_RS02895	COG0038	chloride channel
CAR_RS02910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CAR_RS02915	COG0626	cystathionine gamma-synthase activity
CAR_RS02920	COG2226	methyltransferase
CAR_RS02935	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CAR_RS02960	COG0656	L-ascorbic acid biosynthetic process
CAR_RS02985	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CAR_RS03005	COG0741	lytic transglycosylase activity
CAR_RS03005	COG1196	nuclear chromosome segregation
CAR_RS03005	COG0739	heme binding
CAR_RS03010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAR_RS03045	COG1304	FMN binding
CAR_RS03050	COG1733	regulation of RNA biosynthetic process
CAR_RS03055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CAR_RS03060	COG0072	phenylalanine-tRNA ligase activity
CAR_RS03060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAR_RS03065	COG0531	amino acid
CAR_RS03070	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CAR_RS03080	COG1286	toxin biosynthetic process
CAR_RS03085	COG1193	negative regulation of DNA recombination
CAR_RS03090	COG3118	belongs to the thioredoxin family
CAR_RS03110	COG1272	protein, Hemolysin III
CAR_RS03130	COG4152	abc transporter atp-binding protein
CAR_RS03135	COG1668	transmembrane transport
CAR_RS03140	COG1719	4-vinyl reductase, 4VR
CAR_RS03150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CAR_RS03160	COG0517	IMP dehydrogenase activity
CAR_RS03165	COG2171	N-acyltransferase activity
CAR_RS03175	COG2814	Major facilitator Superfamily
CAR_RS03180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CAR_RS03185	COG0668	transmembrane transport
CAR_RS03195	COG4980	gas vesicle protein
CAR_RS03200	COG0006	proline dipeptidase activity
CAR_RS03205	COG1609	Transcriptional regulator
CAR_RS03220	COG4120	Belongs to the binding-protein-dependent transport system permease family
CAR_RS03230	COG1054	Belongs to the UPF0176 family
CAR_RS03235	COG0519	Catalyzes the synthesis of GMP from XMP
CAR_RS03245	COG1597	lipid kinase activity
CAR_RS03260	COG0217	transcriptional regulatory protein
CAR_RS03265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CAR_RS03275	COG4537	Required for transformation and DNA binding
CAR_RS03300	COG0006	proline dipeptidase activity
CAR_RS03305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAR_RS03310	COG1302	Protein conserved in bacteria
CAR_RS03315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAR_RS03320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAR_RS03325	COG1570	exodeoxyribonuclease VII activity
CAR_RS03330	COG1722	exodeoxyribonuclease VII activity
CAR_RS03340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CAR_RS03345	COG1438	arginine binding
CAR_RS03350	COG0497	DNA recombination
CAR_RS03365	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CAR_RS03370	COG0745	RESPONSE REGULATOR receiver
CAR_RS03375	COG5002	protein histidine kinase activity
CAR_RS03380	COG0706	membrane insertase activity
CAR_RS03385	COG1254	Belongs to the acylphosphatase family
CAR_RS03395	COG1280	lysine exporter protein (LysE YggA)
CAR_RS03395	COG1674	ftsk spoiiie
CAR_RS03400	COG1744	ABC transporter substrate-binding protein PnrA-like
CAR_RS03405	COG3845	ABC transporter
CAR_RS03410	COG4603	Belongs to the binding-protein-dependent transport system permease family
CAR_RS03415	COG1079	Belongs to the binding-protein-dependent transport system permease family
CAR_RS03420	COG0612	Peptidase, M16
CAR_RS03425	COG0612	Peptidase, M16
CAR_RS03435	COG1426	Protein conserved in bacteria
CAR_RS03440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAR_RS03445	COG1546	Belongs to the CinA family
CAR_RS03445	COG1058	Belongs to the CinA family
CAR_RS03455	COG1418	mRNA catabolic process
CAR_RS03460	COG1692	metallophosphoesterase
CAR_RS03465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CAR_RS03480	COG0632	four-way junction helicase activity
CAR_RS03485	COG2255	four-way junction helicase activity
CAR_RS03490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CAR_RS03495	COG1309	transcriptional regulator
CAR_RS03500	COG0343	queuine tRNA-ribosyltransferase activity
CAR_RS03505	COG1862	Preprotein translocase
CAR_RS03515	COG1454	alcohol dehydrogenase
CAR_RS03515	COG1012	belongs to the aldehyde dehydrogenase family
CAR_RS03525	COG0803	Belongs to the bacterial solute-binding protein 9 family
CAR_RS03530	COG1121	(ABC) transporter
CAR_RS03535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAR_RS03540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAR_RS03550	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CAR_RS03555	COG4109	DRTGG domain
CAR_RS03560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CAR_RS03565	COG1253	flavin adenine dinucleotide binding
CAR_RS03570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAR_RS03575	COG3679	Belongs to the UPF0342 family
CAR_RS03580	COG0420	3'-5' exonuclease activity
CAR_RS03585	COG4717	serine-type aminopeptidase activity
CAR_RS03590	COG3481	metal-dependent phosphohydrolase, HD sub domain
CAR_RS03595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAR_RS03605	COG0537	adenosine 5'-monophosphoramidase activity
CAR_RS03610	COG1131	(ABC) transporter
CAR_RS03615	COG4473	ABC transporter
CAR_RS03625	COG0510	thiamine kinase activity
CAR_RS03630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CAR_RS03640	COG1363	Peptidase, m42
CAR_RS03645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAR_RS03650	COG0589	response to stress
CAR_RS03655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAR_RS03660	COG1674	ftsk spoiiie
CAR_RS03665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAR_RS03670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAR_RS03670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAR_RS03675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAR_RS03680	COG0237	dephospho-CoA kinase activity
CAR_RS03690	COG3611	Membrane attachment protein
CAR_RS03695	COG1484	DNA-dependent DNA replication
CAR_RS03700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CAR_RS03705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CAR_RS03710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CAR_RS03715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CAR_RS03720	COG4166	transmembrane transport
CAR_RS03725	COG4166	transmembrane transport
CAR_RS03730	COG1363	Peptidase, m42
CAR_RS03735	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CAR_RS03740	COG1234	tRNA 3'-trailer cleavage
CAR_RS03745	COG0095	Lipoate-protein ligase
CAR_RS03750	COG0180	Tryptophanyl-tRNA synthetase
CAR_RS03760	COG0601	transmembrane transport
CAR_RS03765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAR_RS03770	COG0444	Belongs to the ABC transporter superfamily
CAR_RS03775	COG4608	Belongs to the ABC transporter superfamily
CAR_RS03780	COG1393	Belongs to the ArsC family
CAR_RS03785	COG4862	establishment of competence for transformation
CAR_RS03795	COG1164	Oligoendopeptidase f
CAR_RS03805	COG4116	CYTH
CAR_RS03810	COG2357	RelA SpoT domain protein
CAR_RS03820	COG0564	pseudouridine synthase activity
CAR_RS03825	COG2239	Acts as a magnesium transporter
CAR_RS03845	COG1363	Peptidase, m42
CAR_RS03850	COG0628	permease
CAR_RS03855	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAR_RS03865	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CAR_RS03875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CAR_RS03880	COG0542	response to heat
CAR_RS03895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAR_RS03900	COG2084	Dehydrogenase
CAR_RS03905	COG0436	Aminotransferase
CAR_RS03910	COG4703	Protein of unknown function (DUF1797)
CAR_RS03915	COG0460	homoserine dehydrogenase
CAR_RS03925	COG0083	homoserine kinase activity
CAR_RS03930	COG3142	Participates in the control of copper homeostasis
CAR_RS03935	COG0527	aspartate kinase activity
CAR_RS03940	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CAR_RS03945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CAR_RS03950	COG1534	Rna-binding protein
CAR_RS03955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CAR_RS03960	COG1713	HD superfamily hydrolase involved in NAD metabolism
CAR_RS03965	COG0799	negative regulation of ribosome biogenesis
CAR_RS03970	COG2226	methyltransferase
CAR_RS03975	COG0514	ATP-dependent DNA helicase (RecQ)
CAR_RS03980	COG1323	Belongs to the UPF0348 family
CAR_RS03990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CAR_RS04000	COG2001	Belongs to the MraZ family
CAR_RS04005	COG0275	rRNA processing
CAR_RS04015	COG0768	penicillin binding
CAR_RS04020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAR_RS04025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAR_RS04030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CAR_RS04035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CAR_RS04060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CAR_RS04065	COG1799	cell septum assembly
CAR_RS04070	COG0762	integral membrane protein
CAR_RS04075	COG2302	S4 RNA-binding domain
CAR_RS04080	COG3599	regulation of cell shape
CAR_RS04085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CAR_RS04090	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CAR_RS04110	COG1132	(ABC) transporter
CAR_RS04120	COG3853	Toxic anion resistance protein (TelA)
CAR_RS04140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CAR_RS04160	COG4493	Belongs to the UPF0637 family
CAR_RS04170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CAR_RS04175	COG1956	GAF domain-containing protein
CAR_RS04180	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CAR_RS04185	COG1104	cysteine desulfurase activity
CAR_RS04190	COG0301	tRNA thio-modification
CAR_RS04195	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CAR_RS04200	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CAR_RS04205	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CAR_RS04210	COG0525	valine-tRNA ligase activity
CAR_RS04215	COG0285	dihydrofolate synthase activity
CAR_RS04220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAR_RS04225	COG2003	Belongs to the UPF0758 family
CAR_RS04230	COG1278	Cold shock
CAR_RS04235	COG1278	Cold shock
CAR_RS04240	COG1077	Cell shape determining protein MreB Mrl
CAR_RS04245	COG1792	Involved in formation and maintenance of cell shape
CAR_RS04250	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CAR_RS04260	COG2894	cell division
CAR_RS04265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAR_RS04275	COG0765	amino acid transport
CAR_RS04280	COG1126	abc transporter atp-binding protein
CAR_RS04285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CAR_RS04295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CAR_RS04300	COG0827	DNA restriction-modification system
CAR_RS04305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CAR_RS04310	COG0589	response to stress
CAR_RS04320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CAR_RS04340	COG1104	cysteine desulfurase activity
CAR_RS04350	COG0482	sulfurtransferase activity
CAR_RS04360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CAR_RS04370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CAR_RS04375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CAR_RS04380	COG4472	Bacterial protein of unknown function (DUF965)
CAR_RS04385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CAR_RS04390	COG3906	Belongs to the UPF0473 family
CAR_RS04395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CAR_RS04400	COG0572	uridine kinase
CAR_RS04405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAR_RS04415	COG4585	Histidine kinase
CAR_RS04420	COG2197	response regulator
CAR_RS04425	COG0569	domain protein
CAR_RS04430	COG4841	protein insertion into membrane
CAR_RS04440	COG5503	Protein of unknown function (DUF1447)
CAR_RS04455	COG0561	phosphatase activity
CAR_RS04465	COG0582	viral genome integration into host DNA
CAR_RS04600	COG0028	Belongs to the TPP enzyme family
CAR_RS04610	COG2188	Transcriptional regulator
CAR_RS04620	COG2723	6-phospho-beta-galactosidase activity
CAR_RS04625	COG0242	peptide deformylase activity
CAR_RS04630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CAR_RS04655	COG0039	L-malate dehydrogenase activity
CAR_RS04665	COG0483	inositol monophosphate 1-phosphatase activity
CAR_RS04670	COG1217	gtp-binding protein TYPA
CAR_RS04675	COG0772	Belongs to the SEDS family
CAR_RS04680	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CAR_RS04690	COG4471	UPF0298 protein
CAR_RS04695	COG0742	ribosomal rna small subunit methyltransferase
CAR_RS04700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CAR_RS04705	COG3480	Lon protease (S16) C-terminal proteolytic domain
CAR_RS04720	COG2131	deaminase
CAR_RS04725	COG2333	competence protein COMEC
CAR_RS04725	COG0658	competence protein
CAR_RS04735	COG0268	Binds directly to 16S ribosomal RNA
CAR_RS04740	COG0556	nucleotide-excision repair
CAR_RS04745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CAR_RS04750	COG1185	polyribonucleotide nucleotidyltransferase activity
CAR_RS04760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CAR_RS04765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAR_RS04790	COG1418	mRNA catabolic process
CAR_RS04805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAR_RS04845	COG1269	ATP hydrolysis coupled proton transport
CAR_RS04850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAR_RS04855	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CAR_RS04860	COG1527	subunit (C
CAR_RS04865	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
CAR_RS04870	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CAR_RS04875	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CAR_RS04880	COG1394	ATPase activity, coupled to movement of substances
CAR_RS04885	COG4443	Transcriptional Coactivator p15 (PC4)
CAR_RS04890	COG0194	GDP metabolic process
CAR_RS04895	COG1758	RNA polymerase activity
CAR_RS04900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CAR_RS04905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CAR_RS04915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CAR_RS04920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAR_RS04920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CAR_RS04925	COG0631	protein serine/threonine phosphatase activity
CAR_RS04930	COG2815	serine threonine protein kinase
CAR_RS04930	COG0515	serine threonine protein kinase
CAR_RS04935	COG1162	GTPase activity
CAR_RS04940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CAR_RS04945	COG1564	THIamine pyrophosphokinase
CAR_RS04950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CAR_RS04960	COG1461	Dihydroxyacetone kinase
CAR_RS04965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CAR_RS04970	COG0416	fatty acid biosynthetic process
CAR_RS04975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAR_RS04980	COG0571	ribonuclease III activity
CAR_RS04985	COG1196	nuclear chromosome segregation
CAR_RS04990	COG0561	phosphatase activity
CAR_RS04995	COG0552	protein localization to endoplasmic reticulum
CAR_RS05000	COG1263	PTS System
CAR_RS05000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS05000	COG2190	(PTS) system
CAR_RS05005	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CAR_RS05010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CAR_RS05015	COG0228	four-way junction DNA binding
CAR_RS05020	COG1837	Belongs to the UPF0109 family
CAR_RS05025	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CAR_RS05030	COG0336	Belongs to the RNA methyltransferase TrmD family
CAR_RS05035	COG0335	large ribosomal subunit rRNA binding
CAR_RS05055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CAR_RS05060	COG0561	phosphatase activity
CAR_RS05070	COG2151	metal-sulfur cluster biosynthetic enzyme
CAR_RS05075	COG0542	response to heat
CAR_RS05085	COG0587	DNA-directed DNA polymerase activity
CAR_RS05090	COG0205	6-phosphofructokinase activity
CAR_RS05100	COG2996	Protein conserved in bacteria
CAR_RS05110	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CAR_RS05130	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CAR_RS05135	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CAR_RS05140	COG1187	pseudouridine synthase activity
CAR_RS05145	COG0745	RESPONSE REGULATOR receiver
CAR_RS05150	COG5002	protein histidine kinase activity
CAR_RS05155	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CAR_RS05165	COG0514	ATP-dependent DNA helicase (RecQ)
CAR_RS05180	COG0539	negative regulation of cytoplasmic translation
CAR_RS05185	COG1160	GTP binding
CAR_RS05205	COG0457	Tetratricopeptide repeat
CAR_RS05210	COG5582	Belongs to the UPF0302 family
CAR_RS05215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CAR_RS05220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CAR_RS05225	COG0617	tRNA 3'-terminal CCA addition
CAR_RS05240	COG1199	ATP-dependent helicase activity
CAR_RS05240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAR_RS05250	COG0017	Asparaginyl-tRNA synthetase
CAR_RS05255	COG3935	DnaD domain protein
CAR_RS05260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CAR_RS05270	COG3331	DNA recombination
CAR_RS05275	COG4474	Belongs to the UPF0398 family
CAR_RS05280	COG3599	regulation of cell shape
CAR_RS05285	COG0116	Belongs to the methyltransferase superfamily
CAR_RS05290	COG0328	RNA-DNA hybrid ribonuclease activity
CAR_RS05310	COG0488	(ABC) transporter
CAR_RS05325	COG2755	lipolytic protein G-D-S-L family
CAR_RS05335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAR_RS05340	COG4479	Belongs to the UPF0346 family
CAR_RS05345	COG0813	purine-nucleoside phosphorylase activity
CAR_RS05350	COG0793	Belongs to the peptidase S41A family
CAR_RS05350	COG3409	Peptidoglycan-binding domain 1 protein
CAR_RS05370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CAR_RS05375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CAR_RS05390	COG3763	UPF0154 protein
CAR_RS05395	COG1132	(ABC) transporter
CAR_RS05400	COG1132	(ABC) transporter
CAR_RS05405	COG0204	Acyl-transferase
CAR_RS05410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CAR_RS05415	COG0052	Belongs to the universal ribosomal protein uS2 family
CAR_RS05420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CAR_RS05425	COG0528	UMP kinase activity
CAR_RS05430	COG0233	cytoplasmic translational termination
CAR_RS05435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAR_RS05440	COG4589	Belongs to the CDS family
CAR_RS05445	COG0750	zinc metalloprotease
CAR_RS05450	COG0442	prolyl-tRNA aminoacylation
CAR_RS05455	COG2176	DNA-directed DNA polymerase activity
CAR_RS05460	COG0779	Required for maturation of 30S ribosomal subunits
CAR_RS05465	COG0195	Participates in both transcription termination and antitermination
CAR_RS05470	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CAR_RS05485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CAR_RS05490	COG0726	polysaccharide deacetylase
CAR_RS05500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CAR_RS05505	COG0196	riboflavin kinase activity
CAR_RS05525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CAR_RS05530	COG0443	Heat shock 70 kDa protein
CAR_RS05535	COG0484	heat shock protein binding
CAR_RS05540	COG0481	GTPase activity
CAR_RS05545	COG4974	Belongs to the 'phage' integrase family
CAR_RS05610	COG0583	DNA-binding transcription factor activity
CAR_RS05615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CAR_RS05665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAR_RS05670	COG0667	Aldo Keto reductase
CAR_RS05675	COG0656	L-ascorbic acid biosynthetic process
CAR_RS05685	COG1132	(ABC) transporter
CAR_RS05690	COG1132	(ABC) transporter
CAR_RS05700	COG2094	Belongs to the DNA glycosylase MPG family
CAR_RS05710	COG2264	protein methyltransferase activity
CAR_RS05715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CAR_RS05720	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CAR_RS05725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAR_RS05730	COG1490	D-aminoacyl-tRNA deacylase activity
CAR_RS05735	COG4991	sh3 domain protein
CAR_RS05735	COG0860	N-Acetylmuramoyl-L-alanine amidase
CAR_RS05735	COG3103	Sh3 type 3 domain protein
CAR_RS05740	COG0124	histidyl-tRNA synthetase
CAR_RS05745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CAR_RS05750	COG0616	signal peptide processing
CAR_RS05755	COG1714	RDD family
CAR_RS05760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CAR_RS05765	COG1704	LemA family
CAR_RS05780	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CAR_RS05785	COG0735	belongs to the Fur family
CAR_RS05795	COG1610	YqeY-like protein
CAR_RS05800	COG1702	phosphate starvation-inducible protein PhoH
CAR_RS05810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CAR_RS05825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CAR_RS05830	COG1381	Involved in DNA repair and RecF pathway recombination
CAR_RS05835	COG0752	glycyl-tRNA synthetase alpha subunit
CAR_RS05840	COG0751	glycine-tRNA ligase activity
CAR_RS05845	COG3189	MarR family transcriptional regulator
CAR_RS05850	COG1132	(ABC) transporter
CAR_RS05855	COG1408	metallophosphoesterase
CAR_RS05860	COG1827	regulation of RNA biosynthetic process
CAR_RS05870	COG0358	DNA primase activity
CAR_RS05875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAR_RS05885	COG2384	SAM-dependent methyltransferase
CAR_RS05890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CAR_RS05895	COG2195	Cleaves the N-terminal amino acid of tripeptides
CAR_RS05905	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CAR_RS05910	COG1074	ATP-dependent DNA helicase activity
CAR_RS05920	COG0583	DNA-binding transcription factor activity
CAR_RS05925	COG1304	FMN binding
CAR_RS05930	COG1620	l-lactate permease
CAR_RS05935	COG0596	Alpha beta hydrolase
CAR_RS05940	COG2315	Protein conserved in bacteria
CAR_RS05945	COG0640	Transcriptional regulator
CAR_RS05950	COG2217	Heavy metal translocating P-type atpase
CAR_RS05960	COG0492	ferredoxin-NADP+ reductase activity
CAR_RS06035	COG3507	Belongs to the glycosyl hydrolase 43 family
CAR_RS06040	COG1595	DNA-templated transcription, initiation
CAR_RS06070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CAR_RS06075	COG0564	pseudouridine synthase activity
CAR_RS06080	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CAR_RS06090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAR_RS06095	COG0505	Belongs to the CarA family
CAR_RS06100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAR_RS06135	COG4120	Belongs to the binding-protein-dependent transport system permease family
CAR_RS06140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAR_RS06155	COG0693	protein deglycase activity
CAR_RS06165	COG2011	ABC-type metal ion transport system permease component
CAR_RS06170	COG1464	Belongs to the NlpA lipoprotein family
CAR_RS06190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CAR_RS06215	COG0346	lactoylglutathione lyase activity
CAR_RS06220	COG1227	inorganic diphosphatase activity
CAR_RS06225	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CAR_RS06230	COG1882	Formate acetyltransferase
CAR_RS06240	COG0187	DNA topoisomerase II activity
CAR_RS06255	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CAR_RS06260	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CAR_RS06265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CAR_RS06280	COG0758	DNA mediated transformation
CAR_RS06285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CAR_RS06290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CAR_RS06290	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CAR_RS06300	COG1307	EDD domain protein, DegV family
CAR_RS06310	COG5416	Lipopolysaccharide assembly protein A domain
CAR_RS06315	COG0300	oxidoreductase activity
CAR_RS06320	COG1234	tRNA 3'-trailer cleavage
CAR_RS06325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CAR_RS06330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAR_RS06335	COG1349	DNA-binding transcription factor activity
CAR_RS06340	COG1105	Belongs to the carbohydrate kinase PfkB family
CAR_RS06345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS06345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAR_RS06345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAR_RS06350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CAR_RS06355	COG1126	abc transporter atp-binding protein
CAR_RS06360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAR_RS06370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CAR_RS06375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CAR_RS06380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CAR_RS06385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CAR_RS06390	COG0544	peptidyl-prolyl cis-trans isomerase activity
CAR_RS06405	COG0825	malonyl-CoA metabolic process
CAR_RS06410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CAR_RS06415	COG0439	Biotin carboxylase
CAR_RS06420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAR_RS06425	COG0511	ligase activity, forming carbon-carbon bonds
CAR_RS06430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAR_RS06440	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CAR_RS06450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAR_RS06455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAR_RS06460	COG1846	Transcriptional regulator
CAR_RS06470	COG1846	Transcriptional regulator
CAR_RS06510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAR_RS06515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAR_RS06545	COG0789	Transcriptional regulator
CAR_RS06555	COG0789	Transcriptional regulator
CAR_RS06560	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CAR_RS06565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CAR_RS06575	COG0584	glycerophosphoryl diester phosphodiesterase
CAR_RS06580	COG0166	Belongs to the GPI family
CAR_RS06595	COG1940	carbohydrate kinase activity
CAR_RS06605	COG0705	Rhomboid family
CAR_RS06605	COG0457	Tetratricopeptide repeat
CAR_RS06615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CAR_RS06630	COG0768	penicillin binding
CAR_RS06635	COG4485	Bacterial membrane protein, YfhO
CAR_RS06650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CAR_RS06660	COG0513	Belongs to the DEAD box helicase family
CAR_RS06665	COG3158	transport of potassium into the cell
CAR_RS06670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CAR_RS06675	COG0656	L-ascorbic acid biosynthetic process
CAR_RS06680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAR_RS06685	COG1438	arginine binding
CAR_RS06690	COG0018	arginyl-trna synthetase
CAR_RS06695	COG1607	acyl-coa hydrolase
CAR_RS06700	COG0183	Belongs to the thiolase family
CAR_RS06705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CAR_RS06710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CAR_RS06720	COG4876	unkown
CAR_RS06730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAR_RS06735	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CAR_RS06740	COG4770	biotin carboxylase activity
CAR_RS06755	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CAR_RS06835	COG2188	Transcriptional regulator
CAR_RS06840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CAR_RS06845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CAR_RS06935	COG0366	Alpha amylase catalytic
CAR_RS06940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAR_RS06950	COG5521	maltodextrose utilization protein MalA
CAR_RS06955	COG3833	ABC-type maltose transport systems, permease component
CAR_RS06960	COG1175	transmembrane transport
CAR_RS06965	COG2182	Extracellular solute-binding protein
CAR_RS06970	COG2182	Extracellular solute-binding protein
CAR_RS06980	COG0366	Alpha amylase catalytic
CAR_RS06995	COG1597	lipid kinase activity
CAR_RS07000	COG1609	Transcriptional regulator
CAR_RS07005	COG0735	belongs to the Fur family
CAR_RS07010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CAR_RS07015	COG4129	membrane
CAR_RS07025	COG3557	Belongs to the UPF0374 family
CAR_RS07035	COG2137	regulation of response to DNA damage stimulus
CAR_RS07045	COG1028	Short-chain dehydrogenase reductase Sdr
CAR_RS07070	COG1705	Flagellar rod assembly protein muramidase FlgJ
CAR_RS07070	COG1388	LysM domain
CAR_RS07075	COG1428	Deoxynucleoside kinase
CAR_RS07080	COG0246	Mannitol dehydrogenase
CAR_RS07085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS07090	COG3711	transcriptional antiterminator
CAR_RS07095	COG2213	PTS system mannitol-specific
CAR_RS07100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAR_RS07115	COG1442	glycosyl transferase family 8
CAR_RS07115	COG1216	Glycosyl transferase, family 2
CAR_RS07125	COG0489	protein tyrosine kinase activity
CAR_RS07130	COG3944	biosynthesis protein
CAR_RS07140	COG1442	glycosyl transferase family 8
CAR_RS07140	COG1216	Glycosyl transferase, family 2
CAR_RS07145	COG1215	transferase activity, transferring glycosyl groups
CAR_RS07155	COG0438	transferase activity, transferring glycosyl groups
CAR_RS07160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CAR_RS07165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAR_RS07195	COG3732	PTS system glucitol sorbitol-specific
CAR_RS07200	COG3730	PTS system glucitol sorbitol-specific
CAR_RS07220	COG0561	phosphatase activity
CAR_RS07230	COG1737	Transcriptional regulator
CAR_RS07235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS07235	COG1263	PTS System
CAR_RS07240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CAR_RS07265	COG1609	Transcriptional regulator
CAR_RS07270	COG3459	Glycosyltransferase 36 associated
CAR_RS07280	COG0395	ABC-type sugar transport system, permease component
CAR_RS07285	COG1175	transmembrane transport
CAR_RS07290	COG1653	transport
CAR_RS07295	COG3711	transcriptional antiterminator
CAR_RS07295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS07300	COG1879	ABC-type sugar transport system periplasmic component
CAR_RS07305	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAR_RS07310	COG1129	ABC transporter
CAR_RS07315	COG1869	D-ribose catabolic process
CAR_RS07320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAR_RS07325	COG1609	Transcriptional regulator
CAR_RS07330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CAR_RS07355	COG0371	Dehydrogenase
CAR_RS07395	COG0281	malic enzyme
CAR_RS07435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS07435	COG2190	(PTS) system
CAR_RS07435	COG1263	PTS System
CAR_RS07445	COG0698	ribose 5-phosphate isomerase
CAR_RS07450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CAR_RS07475	COG0800	Aldolase
CAR_RS07480	COG2190	(PTS) system
CAR_RS07480	COG1263	PTS System
CAR_RS07480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS07495	COG1737	Transcriptional regulator
CAR_RS07505	COG1447	Phosphotransferase system cellobiose-specific component IIA
CAR_RS07525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CAR_RS07545	COG4464	protein tyrosine phosphatase activity
CAR_RS07550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CAR_RS07555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CAR_RS07560	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CAR_RS07565	COG3764	Sortase (surface protein transpeptidase)
CAR_RS07575	COG3711	transcriptional antiterminator
CAR_RS07585	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAR_RS07605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS07615	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CAR_RS07620	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CAR_RS07625	COG3457	Alanine racemase
CAR_RS07635	COG2188	Transcriptional regulator
CAR_RS07640	COG0626	cystathionine gamma-synthase activity
CAR_RS07645	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CAR_RS07665	COG4464	protein tyrosine phosphatase activity
CAR_RS07670	COG1091	dTDP-4-dehydrorhamnose reductase activity
CAR_RS07675	COG1088	dTDP-glucose 4,6-dehydratase activity
CAR_RS07680	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CAR_RS07685	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CAR_RS07730	COG0489	protein tyrosine kinase activity
CAR_RS07735	COG3944	biosynthesis protein
CAR_RS07750	COG1316	TRANSCRIPTIONal
CAR_RS07755	COG1388	LysM domain
CAR_RS07755	COG1705	Flagellar rod assembly protein muramidase FlgJ
CAR_RS07760	COG1442	glycosyl transferase family 8
CAR_RS07760	COG1216	Glycosyl transferase, family 2
CAR_RS07770	COG1442	glycosyl transferase family 8
CAR_RS07770	COG1216	Glycosyl transferase, family 2
CAR_RS07790	COG1216	Glycosyl transferase, family 2
CAR_RS07795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAR_RS07805	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CAR_RS07810	COG1216	Glycosyl transferase, family 2
CAR_RS07815	COG2244	polysaccharide biosynthetic process
CAR_RS07820	COG1216	Glycosyl transferase, family 2
CAR_RS07820	COG1442	glycosyl transferase family 8
CAR_RS07825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CAR_RS07835	COG3274	enterobacterial common antigen metabolic process
CAR_RS07840	COG0024	Methionine aminopeptidase
CAR_RS07845	COG0564	pseudouridine synthase activity
CAR_RS07860	COG0716	FMN binding
CAR_RS07870	COG2309	aminopeptidase activity
CAR_RS07900	COG1131	(ABC) transporter
CAR_RS07905	COG1725	Transcriptional regulator
CAR_RS07920	COG0513	Belongs to the DEAD box helicase family
CAR_RS07925	COG0673	inositol 2-dehydrogenase activity
CAR_RS07935	COG0656	L-ascorbic acid biosynthetic process
CAR_RS07940	COG1408	metallophosphoesterase
CAR_RS07965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAR_RS07965	COG1522	sequence-specific DNA binding
CAR_RS07970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAR_RS07985	COG0668	transmembrane transport
CAR_RS07990	COG0534	Mate efflux family protein
CAR_RS07995	COG1307	EDD domain protein, DegV family
CAR_RS08015	COG1442	glycosyl transferase family 8
CAR_RS08020	COG1550	Protein conserved in bacteria
CAR_RS08025	COG1187	pseudouridine synthase activity
CAR_RS08065	COG2133	pyrroloquinoline quinone binding
CAR_RS08085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAR_RS08090	COG1597	lipid kinase activity
CAR_RS08095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAR_RS08100	COG0154	amidase activity
CAR_RS08105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAR_RS08110	COG1073	alpha beta
CAR_RS08125	COG0583	DNA-binding transcription factor activity
CAR_RS08130	COG0183	Belongs to the thiolase family
CAR_RS08135	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAR_RS08135	COG1024	Enoyl-CoA hydratase
CAR_RS08140	COG0427	acetyl-CoA hydrolase
CAR_RS08145	COG1960	acyl-CoA dehydrogenase activity
CAR_RS08155	COG4851	CamS sex pheromone cAM373 precursor
CAR_RS08160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CAR_RS08165	COG0210	DNA helicase
CAR_RS08175	COG0697	spore germination
CAR_RS08180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CAR_RS08185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CAR_RS08190	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CAR_RS08205	COG1253	flavin adenine dinucleotide binding
CAR_RS08220	COG1705	Flagellar rod assembly protein muramidase FlgJ
CAR_RS08225	COG1876	peptidase activity
CAR_RS08280	COG0410	ABC transporter
CAR_RS08305	COG4129	membrane
CAR_RS08325	COG0531	amino acid
CAR_RS08330	COG4975	Glucose uptake
CAR_RS08335	COG2081	HI0933 family
CAR_RS08345	COG0431	NADPH-dependent FMN reductase
CAR_RS08350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAR_RS08360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CAR_RS08365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CAR_RS08375	COG1368	sulfuric ester hydrolase activity
CAR_RS08395	COG0745	RESPONSE REGULATOR receiver
CAR_RS08400	COG3584	3D domain protein
CAR_RS08400	COG1388	LysM domain
CAR_RS08405	COG0629	single-stranded DNA binding
CAR_RS08420	COG1077	Cell shape determining protein MreB Mrl
CAR_RS08425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAR_RS08435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CAR_RS08440	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CAR_RS08445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CAR_RS08450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CAR_RS08455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAR_RS08460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CAR_RS08465	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAR_RS08470	COG0356	it plays a direct role in the translocation of protons across the membrane
CAR_RS08475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CAR_RS08485	COG0009	L-threonylcarbamoyladenylate synthase
CAR_RS08490	COG2890	protein-(glutamine-N5) methyltransferase activity
CAR_RS08495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CAR_RS08500	COG1435	thymidine kinase activity
CAR_RS08505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CAR_RS08510	COG3442	glutamine amidotransferase
CAR_RS08515	COG1482	cell wall glycoprotein biosynthetic process
CAR_RS08525	COG2514	catechol 2,3-dioxygenase activity
CAR_RS08535	COG1132	(ABC) transporter
CAR_RS08545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAR_RS08550	COG0628	permease
CAR_RS08555	COG3731	PTS system glucitol sorbitol-specific IIA component
CAR_RS08565	COG2706	6-phosphogluconolactonase activity
CAR_RS08570	COG0346	lactoylglutathione lyase activity
CAR_RS08575	COG0346	lactoylglutathione lyase activity
CAR_RS08580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CAR_RS08590	COG1131	(ABC) transporter
CAR_RS08595	COG2190	(PTS) system
CAR_RS08595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS08595	COG1263	PTS System
CAR_RS08610	COG1968	undecaprenyl-diphosphatase activity
CAR_RS08615	COG0527	aspartate kinase activity
CAR_RS08630	COG4166	transmembrane transport
CAR_RS08635	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CAR_RS08655	COG0058	SHG alpha-glucan phosphorylase activity
CAR_RS08665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CAR_RS08690	COG4864	UPF0365 protein
CAR_RS08700	COG0004	ammonium transporteR
CAR_RS08705	COG1940	carbohydrate kinase activity
CAR_RS08710	COG1196	nuclear chromosome segregation
CAR_RS08710	COG0741	lytic transglycosylase activity
CAR_RS08710	COG0739	heme binding
CAR_RS08725	COG2096	Adenosyltransferase
CAR_RS08740	COG1011	Hydrolase
CAR_RS08745	COG0277	FAD linked oxidase domain protein
CAR_RS08760	COG0509	glycine decarboxylation via glycine cleavage system
CAR_RS08765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAR_RS08770	COG1393	Belongs to the ArsC family
CAR_RS08775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAR_RS08780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAR_RS08785	COG1301	dicarboxylic acid transport
CAR_RS08795	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CAR_RS08800	COG2508	Transcriptional regulator
CAR_RS08815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAR_RS08820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAR_RS08825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CAR_RS08830	COG3257	ureidoglycine aminohydrolase activity
CAR_RS08835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAR_RS08845	COG1737	Transcriptional regulator
CAR_RS08850	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CAR_RS08855	COG2190	(PTS) system
CAR_RS08855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS08855	COG1263	PTS System
CAR_RS08865	COG4166	transmembrane transport
CAR_RS08875	COG2270	Major facilitator Superfamily
CAR_RS08880	COG1368	sulfuric ester hydrolase activity
CAR_RS08895	COG0346	lactoylglutathione lyase activity
CAR_RS08940	COG0459	protein refolding
CAR_RS08945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CAR_RS08950	COG1266	CAAX protease self-immunity
CAR_RS08960	COG0488	(ABC) transporter
CAR_RS08965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CAR_RS08970	COG0456	acetyltransferase
CAR_RS08980	COG1214	PFAM Peptidase M22, glycoprotease
CAR_RS08995	COG0628	permease
CAR_RS09000	COG2252	PERMEase
CAR_RS09015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAR_RS09020	COG1442	glycosyl transferase family 8
CAR_RS09030	COG2059	Chromate
CAR_RS09035	COG1285	pathogenesis
CAR_RS09040	COG4485	Bacterial membrane protein, YfhO
CAR_RS09045	COG2246	polysaccharide biosynthetic process
CAR_RS09050	COG0463	Glycosyl transferase, family 2
CAR_RS09060	COG0588	phosphoglycerate mutase activity
CAR_RS09080	COG1733	regulation of RNA biosynthetic process
CAR_RS09085	COG1902	pentaerythritol trinitrate reductase activity
CAR_RS09090	COG1609	Transcriptional regulator
CAR_RS09095	COG2017	converts alpha-aldose to the beta-anomer
CAR_RS09100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAR_RS09105	COG1554	hydrolase, family 65, central catalytic
CAR_RS09110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS09110	COG1263	PTS System
CAR_RS09110	COG2190	(PTS) system
CAR_RS09130	COG0488	(ABC) transporter
CAR_RS09150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAR_RS09150	COG0519	Catalyzes the synthesis of GMP from XMP
CAR_RS09155	COG1072	(Pantothenic acid kinase))
CAR_RS09170	COG0083	homoserine kinase activity
CAR_RS09185	COG1304	FMN binding
CAR_RS09210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CAR_RS09215	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CAR_RS09220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAR_RS09225	COG1177	transmembrane transport
CAR_RS09230	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAR_RS09235	COG3842	ATPase activity
CAR_RS09245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CAR_RS09250	COG0569	domain protein
CAR_RS09255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CAR_RS09265	COG0708	Exodeoxyribonuclease III
CAR_RS09270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CAR_RS09280	COG0765	amino acid transport
CAR_RS09285	COG1126	abc transporter atp-binding protein
CAR_RS09295	COG0802	atpase or kinase
CAR_RS09300	COG2910	NAD(P)H-binding
CAR_RS09305	COG0280	phosphate acetyltransferase
CAR_RS09310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CAR_RS09315	COG0561	phosphatase activity
CAR_RS09335	COG0765	amino acid transport
CAR_RS09340	COG1126	abc transporter atp-binding protein
CAR_RS09345	COG1511	domain protein
CAR_RS09375	COG1388	LysM domain
CAR_RS09375	COG3584	3D domain protein
CAR_RS09385	COG1114	Component of the transport system for branched-chain amino acids
CAR_RS09390	COG0765	amino acid transport
CAR_RS09395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAR_RS09410	COG0783	Belongs to the Dps family
CAR_RS09415	COG0488	(ABC) transporter
CAR_RS09420	COG3706	GGDEF domain
CAR_RS09440	COG1132	(ABC) transporter
CAR_RS09445	COG1132	(ABC) transporter
CAR_RS09450	COG1442	glycosyl transferase family 8
CAR_RS09455	COG1442	glycosyl transferase family 8
CAR_RS09465	COG0419	ATPase involved in DNA repair
CAR_RS09475	COG0824	Thioesterase
CAR_RS09480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CAR_RS09500	COG1136	(ABC) transporter
CAR_RS09515	COG3579	cysteine-type endopeptidase activity
CAR_RS09520	COG2608	mercury ion transmembrane transporter activity
CAR_RS09525	COG2217	Heavy metal translocating P-type atpase
CAR_RS09530	COG3682	Transcriptional regulator
CAR_RS09535	COG1360	Flagellar Motor Protein
CAR_RS09540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CAR_RS09560	COG1233	COG1233 Phytoene dehydrogenase and related
CAR_RS09570	COG1233	COG1233 Phytoene dehydrogenase and related
CAR_RS09580	COG1136	(ABC) transporter
CAR_RS09585	COG0577	efflux transmembrane transporter activity
CAR_RS09590	COG0494	nUDIX hydrolase
CAR_RS09620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS09620	COG1263	PTS System
CAR_RS09635	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CAR_RS09645	COG3425	synthase
CAR_RS09655	COG2723	6-phospho-beta-galactosidase activity
CAR_RS09660	COG1447	Phosphotransferase system cellobiose-specific component IIA
CAR_RS09665	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CAR_RS09670	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CAR_RS09670	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CAR_RS09675	COG2188	Transcriptional regulator
CAR_RS09680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CAR_RS09685	COG2723	6-phospho-beta-galactosidase activity
CAR_RS09690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CAR_RS09710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAR_RS09715	COG1621	beta-fructofuranosidase activity
CAR_RS09725	COG1874	Beta-galactosidase
CAR_RS09730	COG3833	ABC-type maltose transport systems, permease component
CAR_RS09735	COG1175	transmembrane transport
CAR_RS09740	COG2182	Extracellular solute-binding protein
CAR_RS09745	COG1609	Transcriptional regulator
CAR_RS09750	COG1609	Transcriptional regulator
CAR_RS09755	COG1940	carbohydrate kinase activity
CAR_RS09760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAR_RS09780	COG2235	arginine
CAR_RS09785	COG1438	arginine binding
CAR_RS09790	COG1764	response to oxidative stress
CAR_RS09795	COG1846	Transcriptional regulator
CAR_RS09800	COG0432	Pfam Uncharacterised protein family UPF0047
CAR_RS09810	COG0840	transmembrane signaling receptor activity
CAR_RS09815	COG0840	transmembrane signaling receptor activity
CAR_RS09820	COG2884	Cell division ATP-binding protein ftsE
CAR_RS09825	COG4786	Flagellar basal body rod
CAR_RS09830	COG4786	Flagellar basal body rod
CAR_RS09835	COG1191	sigma factor activity
CAR_RS09840	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAR_RS09845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAR_RS09850	COG1684	flagellar biosynthetic protein fliR
CAR_RS09855	COG1987	bacterial-type flagellum assembly
CAR_RS09860	COG1338	Plays a role in the flagellum-specific transport system
CAR_RS09890	COG4786	Flagellar basal body rod
CAR_RS09915	COG1157	protein secretion by the type III secretion system
CAR_RS09925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CAR_RS09935	COG1677	Flagellar hook-basal body complex protein FliE
CAR_RS09940	COG1558	bacterial-type flagellum-dependent cell motility
CAR_RS09945	COG1815	bacterial-type flagellum-dependent cell motility
CAR_RS09950	COG1516	flagellar protein fliS
CAR_RS09970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAR_RS09975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAR_RS09980	COG4786	Flagellar basal body rod
CAR_RS09980	COG1256	bacterial-type flagellum assembly
CAR_RS09995	COG1776	CheC inhibitor of MCP methylation
CAR_RS09995	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CAR_RS10000	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CAR_RS10005	COG0835	chemotaxis
CAR_RS10010	COG2201	protein-glutamate methylesterase activity
CAR_RS10015	COG1776	CheC inhibitor of MCP methylation
CAR_RS10020	COG2198	Histidine kinase
CAR_RS10020	COG0643	Histidine kinase
CAR_RS10025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAR_RS10030	COG2201	protein-glutamate methylesterase activity
CAR_RS10035	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CAR_RS10040	COG0835	chemotaxis
CAR_RS10045	COG0840	transmembrane signaling receptor activity
CAR_RS10050	COG4989	oxidoreductase activity
CAR_RS10065	COG1902	pentaerythritol trinitrate reductase activity
CAR_RS10070	COG0071	Belongs to the small heat shock protein (HSP20) family
CAR_RS10095	COG1695	Transcriptional regulator
CAR_RS10110	COG1164	Oligoendopeptidase f
CAR_RS10115	COG2195	Cleaves the N-terminal amino acid of tripeptides
CAR_RS10120	COG4166	transmembrane transport
CAR_RS10130	COG3973	AAA domain
CAR_RS10135	COG3871	stress protein (general stress protein 26)
CAR_RS10140	COG2326	polyphosphate kinase activity
CAR_RS10145	COG2910	NAD(P)H-binding
CAR_RS10150	COG1393	Belongs to the ArsC family
CAR_RS10165	COG0657	acetylesterase activity
CAR_RS10175	COG0456	acetyltransferase
CAR_RS10190	COG4166	transmembrane transport
CAR_RS10195	COG1307	EDD domain protein, DegV family
CAR_RS10205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAR_RS10210	COG0390	transport system, permease component
CAR_RS10215	COG4619	ABC transporter
CAR_RS10225	COG0045	succinate-CoA ligase (ADP-forming) activity
CAR_RS10230	COG1301	dicarboxylic acid transport
CAR_RS10235	COG1105	Belongs to the carbohydrate kinase PfkB family
CAR_RS10240	COG1388	LysM domain
CAR_RS10245	COG2217	Heavy metal translocating P-type atpase
CAR_RS10265	COG3639	organic phosphonate transmembrane transporter activity
CAR_RS10270	COG0737	Belongs to the 5'-nucleotidase family
CAR_RS10275	COG2814	Major facilitator Superfamily
CAR_RS10280	COG3588	fructose-bisphosphate aldolase
CAR_RS10290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS10295	COG3711	transcriptional antiterminator
CAR_RS10305	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CAR_RS10310	COG1737	Transcriptional regulator
CAR_RS10315	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CAR_RS10320	COG1028	Short-chain dehydrogenase reductase Sdr
CAR_RS10325	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAR_RS10330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAR_RS10340	COG1216	Glycosyl transferase, family 2
CAR_RS10360	COG1028	Short-chain dehydrogenase reductase Sdr
CAR_RS10365	COG1312	Catalyzes the dehydration of D-mannonate
CAR_RS10370	COG1904	glucuronate isomerase
CAR_RS10375	COG0800	Aldolase
CAR_RS10390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAR_RS10395	COG3250	beta-galactosidase activity
CAR_RS10400	COG4753	response regulator
CAR_RS10400	COG2207	Transcriptional regulator
CAR_RS10410	COG0402	S-adenosylhomocysteine deaminase activity
CAR_RS10415	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CAR_RS10420	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAR_RS10425	COG3842	ATPase activity
CAR_RS10430	COG1177	transmembrane transport
CAR_RS10435	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAR_RS10455	COG1028	Short-chain dehydrogenase reductase Sdr
CAR_RS10475	COG2086	electron transfer activity
CAR_RS10480	COG1960	acyl-CoA dehydrogenase activity
CAR_RS10485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAR_RS10505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAR_RS10520	COG0346	lactoylglutathione lyase activity
CAR_RS10525	COG0110	maltose O-acetyltransferase activity
CAR_RS10530	COG2211	Major facilitator Superfamily
CAR_RS10540	COG1473	amidohydrolase
CAR_RS10560	COG1132	(ABC) transporter
CAR_RS10565	COG1132	(ABC) transporter
CAR_RS10570	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAR_RS10580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAR_RS10605	COG0673	inositol 2-dehydrogenase activity
CAR_RS10620	COG4297	protein containing double-stranded beta helix domain
CAR_RS10640	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CAR_RS10645	COG2115	Belongs to the xylose isomerase family
CAR_RS10655	COG1070	Carbohydrate kinase
CAR_RS10660	COG3507	Belongs to the glycosyl hydrolase 43 family
CAR_RS10665	COG2115	Belongs to the xylose isomerase family
CAR_RS10670	COG0395	ABC-type sugar transport system, permease component
CAR_RS10675	COG1175	transmembrane transport
CAR_RS10685	COG1940	carbohydrate kinase activity
CAR_RS10685	COG1846	Transcriptional regulator
CAR_RS10695	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CAR_RS10705	COG0251	oxidation-reduction process
CAR_RS10710	COG2964	Protein conserved in bacteria
CAR_RS10715	COG3775	system Galactitol-specific IIC component
CAR_RS10720	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS10725	COG3414	Phosphotransferase system galactitol-specific IIB component
CAR_RS10730	COG3711	transcriptional antiterminator
CAR_RS10730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS10735	COG1201	RNA secondary structure unwinding
CAR_RS10750	COG1307	EDD domain protein, DegV family
CAR_RS10755	COG3443	Belongs to the bacterial solute-binding protein 9 family
CAR_RS10760	COG0803	Belongs to the bacterial solute-binding protein 9 family
CAR_RS10760	COG3443	Belongs to the bacterial solute-binding protein 9 family
CAR_RS10780	COG3684	Belongs to the aldolase LacD family
CAR_RS10790	COG2222	sugar isomerase
CAR_RS10795	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS10795	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS10800	COG3716	PTS system mannose fructose sorbose family IID component
CAR_RS10820	COG2188	Transcriptional regulator
CAR_RS10835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CAR_RS10850	COG1609	Transcriptional regulator
CAR_RS10855	COG0427	acetyl-CoA hydrolase
CAR_RS10860	COG1024	Enoyl-CoA hydratase
CAR_RS10865	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAR_RS10870	COG1960	acyl-CoA dehydrogenase activity
CAR_RS10875	COG0183	Belongs to the thiolase family
CAR_RS10880	COG0583	DNA-binding transcription factor activity
CAR_RS10885	COG1960	acyl-CoA dehydrogenase activity
CAR_RS10890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAR_RS10910	COG1966	Carbon starvation protein
CAR_RS10915	COG3279	Response regulator of the LytR AlgR family
CAR_RS10920	COG3275	phosphorelay sensor kinase activity
CAR_RS10925	COG3655	Transcriptional regulator
CAR_RS10935	COG5646	InterPro IPR014922
CAR_RS10940	COG1476	TRANSCRIPTIONal
CAR_RS10960	COG1609	Transcriptional regulator
CAR_RS10965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CAR_RS10970	COG4214	carbohydrate transport
CAR_RS10985	COG2207	Transcriptional regulator
CAR_RS10985	COG1917	Cupin 2, conserved barrel domain protein
CAR_RS10990	COG2211	Major facilitator Superfamily
CAR_RS11005	COG0300	oxidoreductase activity
CAR_RS11055	COG0346	lactoylglutathione lyase activity
CAR_RS11060	COG0346	lactoylglutathione lyase activity
CAR_RS11065	COG0400	carboxylic ester hydrolase activity
CAR_RS11095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CAR_RS11100	COG1428	Deoxynucleoside kinase
CAR_RS11110	COG1917	Cupin 2, conserved barrel domain protein
CAR_RS11110	COG2207	Transcriptional regulator
CAR_RS11115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAR_RS11115	COG3320	Male sterility
CAR_RS11140	COG2860	membrane
CAR_RS11155	COG1349	DNA-binding transcription factor activity
CAR_RS11200	COG2195	Cleaves the N-terminal amino acid of tripeptides
CAR_RS11210	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CAR_RS11230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CAR_RS11235	COG2188	Transcriptional regulator
CAR_RS11240	COG2723	6-phospho-beta-galactosidase activity
CAR_RS11245	COG0667	Aldo Keto reductase
CAR_RS11255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAR_RS11260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAR_RS11265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAR_RS11270	COG0667	Aldo Keto reductase
CAR_RS11285	COG1129	ABC transporter
CAR_RS11300	COG2972	Histidine kinase
CAR_RS11305	COG2207	Transcriptional regulator
CAR_RS11305	COG4753	response regulator
CAR_RS11310	COG0456	acetyltransferase
CAR_RS11315	COG1846	Transcriptional regulator
CAR_RS11320	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAR_RS11325	COG2814	Major facilitator Superfamily
CAR_RS11330	COG0745	RESPONSE REGULATOR receiver
CAR_RS11335	COG2205	protein histidine kinase activity
CAR_RS11345	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CAR_RS11350	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CAR_RS11365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CAR_RS11370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAR_RS11375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CAR_RS11385	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CAR_RS11390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CAR_RS11400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CAR_RS11410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CAR_RS11425	COG1937	Protein conserved in bacteria
CAR_RS11430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAR_RS11430	COG0425	Belongs to the sulfur carrier protein TusA family
CAR_RS11435	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAR_RS11440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAR_RS11445	COG0662	Cupin 2, conserved barrel domain protein
CAR_RS11450	COG4619	ABC transporter
CAR_RS11455	COG0390	transport system, permease component
CAR_RS11460	COG2217	Heavy metal translocating P-type atpase
CAR_RS11470	COG0435	Glutathione S-transferase
CAR_RS11480	COG1733	regulation of RNA biosynthetic process
CAR_RS11490	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CAR_RS11495	COG0673	inositol 2-dehydrogenase activity
CAR_RS11500	COG0673	inositol 2-dehydrogenase activity
CAR_RS11510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CAR_RS11520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAR_RS11525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS11530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAR_RS11535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS11535	COG3711	transcriptional antiterminator
CAR_RS11545	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CAR_RS11570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CAR_RS11580	COG0574	Belongs to the PEP-utilizing enzyme family
CAR_RS11580	COG3848	Pyruvate phosphate dikinase
CAR_RS11585	COG1183	phosphatidylcholine synthase activity
CAR_RS11590	COG0688	phosphatidylethanolamine metabolic process
CAR_RS11610	COG0702	epimerase
CAR_RS11615	COG0656	L-ascorbic acid biosynthetic process
CAR_RS11620	COG0110	maltose O-acetyltransferase activity
CAR_RS11625	COG0583	DNA-binding transcription factor activity
CAR_RS11630	COG0383	alpha-mannosidase activity
CAR_RS11635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAR_RS11640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAR_RS11645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAR_RS11645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CAR_RS11645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS11650	COG3711	transcriptional antiterminator
CAR_RS11650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAR_RS11655	COG1473	amidohydrolase
CAR_RS11660	COG4608	Belongs to the ABC transporter superfamily
CAR_RS11665	COG0444	Belongs to the ABC transporter superfamily
CAR_RS11680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAR_RS11685	COG0601	transmembrane transport
CAR_RS11705	COG1028	Short-chain dehydrogenase reductase Sdr
CAR_RS11710	COG3775	system Galactitol-specific IIC component
CAR_RS11715	COG0800	Aldolase
CAR_RS11720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAR_RS11730	COG1454	alcohol dehydrogenase
CAR_RS11735	COG3254	rhamnose metabolic process
CAR_RS11745	COG0235	Class ii aldolase
CAR_RS11755	COG1070	Carbohydrate kinase
CAR_RS11780	COG3791	Glutathione-dependent formaldehyde-activating
CAR_RS11795	COG1733	regulation of RNA biosynthetic process
CAR_RS11805	COG1053	succinate dehydrogenase
CAR_RS11810	COG1902	pentaerythritol trinitrate reductase activity
CAR_RS11815	COG2832	Protein of unknown function (DUF454)
CAR_RS11820	COG1053	succinate dehydrogenase
CAR_RS11820	COG3976	FMN-binding domain protein
CAR_RS11820	COG0431	NADPH-dependent FMN reductase
CAR_RS11830	COG0151	Belongs to the GarS family
CAR_RS11835	COG0138	bifunctional purine biosynthesis protein purh
CAR_RS11840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CAR_RS11845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CAR_RS11855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAR_RS11865	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAR_RS11870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CAR_RS11875	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CAR_RS11880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CAR_RS11890	COG2268	Band 7 protein
CAR_RS11910	COG0438	transferase activity, transferring glycosyl groups
CAR_RS11920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CAR_RS11930	COG2153	protein acetylation
CAR_RS11980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CAR_RS11985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CAR_RS11990	COG0101	tRNA pseudouridine synthase activity
CAR_RS12000	COG1122	ATPase activity
CAR_RS12005	COG1122	ATPase activity
CAR_RS12010	COG0203	ribosomal protein L17
CAR_RS12015	COG0202	RNA polymerase activity
CAR_RS12020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CAR_RS12025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CAR_RS12030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CAR_RS12035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CAR_RS12040	COG0563	adenylate kinase activity
CAR_RS12055	COG1841	ribosomal large subunit assembly
CAR_RS12060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CAR_RS12065	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CAR_RS12075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CAR_RS12085	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CAR_RS12095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CAR_RS12100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CAR_RS12110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CAR_RS12115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CAR_RS12120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CAR_RS12130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CAR_RS12135	COG0089	rRNA binding
CAR_RS12140	COG0088	Forms part of the polypeptide exit tunnel
CAR_RS12145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CAR_RS12150	COG0051	transcription antitermination factor activity, RNA binding
CAR_RS12155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAR_RS12165	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAR_RS12170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAR_RS12175	COG0049	tRNA binding
CAR_RS12180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CAR_RS12185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CAR_RS12190	COG1012	belongs to the aldehyde dehydrogenase family
CAR_RS12195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CAR_RS12205	COG2813	Specifically methylates the guanine in position
CAR_RS12210	COG0222	ribosome binding
CAR_RS12215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CAR_RS12220	COG0081	regulation of translation
CAR_RS12225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CAR_RS12240	COG2113	Glycine betaine
CAR_RS12245	COG0250	Participates in transcription elongation, termination and antitermination
CAR_RS12250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CAR_RS12255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CAR_RS12295	COG3688	RNA-binding protein containing a PIN domain
CAR_RS12300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAR_RS12305	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CAR_RS12310	COG0215	cysteine-tRNA ligase activity
CAR_RS12315	COG1045	serine acetyltransferase
CAR_RS12320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAR_RS12330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CAR_RS12335	COG4956	integral membrane protein (PIN domain superfamily)
CAR_RS12340	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CAR_RS12345	COG0756	dUTP diphosphatase activity
CAR_RS12350	COG3842	ATPase activity
CAR_RS12370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAR_RS12375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CAR_RS12395	COG0517	IMP dehydrogenase activity
CAR_RS12395	COG0516	GMP reductase activity
CAR_RS12405	COG0012	GTP binding
CAR_RS12410	COG4481	Protein conserved in bacteria
CAR_RS12415	COG1475	DNA binding
CAR_RS12420	COG1192	Involved in chromosome partitioning
CAR_RS12425	COG1475	DNA binding
CAR_RS12430	COG0357	Ribosomal RNA small subunit methyltransferase G
CAR_RS12445	COG0445	tRNA wobble uridine modification
CAR_RS12450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CAR_RS12470	COG3583	domain protein
CAR_RS12470	COG3584	3D domain protein
CAR_RS12480	COG2188	Transcriptional regulator
CAR_RS12490	COG0366	Alpha amylase catalytic
CAR_RS12495	COG1263	PTS System
CAR_RS12495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAR_RS12500	COG0577	efflux transmembrane transporter activity
CAR_RS12505	COG1136	(ABC) transporter
CAR_RS12510	COG2205	protein histidine kinase activity
CAR_RS12520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CAR_RS12525	COG0706	membrane insertase activity
CAR_RS12535	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CAR_RS12545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CAR_RS12570	COG0187	DNA topoisomerase II activity
CAR_RS12575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CAR_RS12675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CAR_RS12800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAR_RS12805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAR_RS12825	COG3655	Transcriptional regulator
CAR_RS12850	COG2199	diguanylate cyclase activity
CAR_RS12850	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain