locus-tag	class	description
JHE06_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JHE06_RS00010	COG0592	DNA-directed DNA polymerase activity
JHE06_RS00015	COG2501	S4 domain
JHE06_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JHE06_RS00025	COG0187	DNA topoisomerase II activity
JHE06_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JHE06_RS00055	COG0359	binds to the 23S rRNA
JHE06_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
JHE06_RS00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JHE06_RS00070	COG0656	L-ascorbic acid biosynthetic process
JHE06_RS00090	COG2155	Conserved Protein
JHE06_RS00110	COG2190	(PTS) system
JHE06_RS00110	COG1263	PTS System
JHE06_RS00110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS00115	COG0745	RESPONSE REGULATOR receiver
JHE06_RS00130	COG4853	Protein conserved in bacteria
JHE06_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JHE06_RS00140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHE06_RS00150	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JHE06_RS00170	COG0625	glutathione transferase activity
JHE06_RS00175	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JHE06_RS00195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHE06_RS00205	COG1263	PTS System
JHE06_RS00205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS00205	COG2190	(PTS) system
JHE06_RS00210	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
JHE06_RS00230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHE06_RS00240	COG2233	PERMEase
JHE06_RS00245	COG4807	Protein conserved in bacteria
JHE06_RS00285	COG0583	DNA-binding transcription factor activity
JHE06_RS00290	COG0659	secondary active sulfate transmembrane transporter activity
JHE06_RS00295	COG1575	Belongs to the MenA family. Type 1 subfamily
JHE06_RS00305	COG0791	NLP P60 protein
JHE06_RS00310	COG4166	transmembrane transport
JHE06_RS00320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHE06_RS00325	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JHE06_RS00330	COG1461	Dihydroxyacetone kinase
JHE06_RS00335	COG2376	Dihydroxyacetone kinase
JHE06_RS00340	COG0772	Belongs to the SEDS family
JHE06_RS00350	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHE06_RS00375	COG1473	amidohydrolase
JHE06_RS00380	COG1473	amidohydrolase
JHE06_RS00385	COG0702	epimerase
JHE06_RS00415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHE06_RS00425	COG0561	phosphatase activity
JHE06_RS00430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHE06_RS00430	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHE06_RS00435	COG0084	hydrolase, TatD family'
JHE06_RS00445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JHE06_RS00450	COG4466	Protein conserved in bacteria
JHE06_RS00455	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JHE06_RS00460	COG1121	(ABC) transporter
JHE06_RS00465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHE06_RS00470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JHE06_RS00485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JHE06_RS00495	COG4166	transmembrane transport
JHE06_RS00500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHE06_RS00505	COG0039	L-malate dehydrogenase activity
JHE06_RS00510	COG0193	aminoacyl-tRNA hydrolase activity
JHE06_RS00515	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JHE06_RS00520	COG2244	polysaccharide biosynthetic process
JHE06_RS00525	COG3956	TIGRFAM MazG family protein
JHE06_RS00530	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JHE06_RS00535	COG2113	Glycine betaine
JHE06_RS00555	COG0071	Belongs to the small heat shock protein (HSP20) family
JHE06_RS00570	COG2814	Major facilitator Superfamily
JHE06_RS00575	COG0488	(ABC) transporter
JHE06_RS00610	COG1098	S1 RNA binding domain
JHE06_RS00615	COG0037	tRNA processing
JHE06_RS00630	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JHE06_RS00635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JHE06_RS00640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JHE06_RS00675	COG0135	phosphoribosylanthranilate isomerase activity
JHE06_RS00745	COG4463	regulation of RNA biosynthetic process
JHE06_RS00750	COG0542	response to heat
JHE06_RS00765	COG0590	tRNA wobble adenosine to inosine editing
JHE06_RS00770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JHE06_RS00780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JHE06_RS00785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHE06_RS00800	COG0516	GMP reductase activity
JHE06_RS00815	COG1131	(ABC) transporter
JHE06_RS00820	COG1725	Transcriptional regulator
JHE06_RS00825	COG2124	cytochrome p450
JHE06_RS00840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JHE06_RS00845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JHE06_RS00850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JHE06_RS00865	COG3870	Protein conserved in bacteria
JHE06_RS00870	COG0470	DNA polymerase III
JHE06_RS00890	COG1063	alcohol dehydrogenase
JHE06_RS00895	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JHE06_RS00900	COG2827	Endonuclease containing a URI domain
JHE06_RS00905	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JHE06_RS00910	COG2814	Major facilitator Superfamily
JHE06_RS00935	COG2244	polysaccharide biosynthetic process
JHE06_RS00975	COG0351	phosphomethylpyrimidine kinase
JHE06_RS01020	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHE06_RS01025	COG1132	(ABC) transporter
JHE06_RS01030	COG1132	(ABC) transporter
JHE06_RS01035	COG0300	oxidoreductase activity
JHE06_RS01040	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHE06_RS01055	COG1028	Short-chain dehydrogenase reductase Sdr
JHE06_RS01060	COG0456	acetyltransferase
JHE06_RS01065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHE06_RS01070	COG0739	heme binding
JHE06_RS01070	COG0741	lytic transglycosylase activity
JHE06_RS01070	COG1196	nuclear chromosome segregation
JHE06_RS01080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JHE06_RS01085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JHE06_RS01100	COG0693	protein deglycase activity
JHE06_RS01120	COG0431	NADPH-dependent FMN reductase
JHE06_RS01125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JHE06_RS01130	COG1737	Transcriptional regulator
JHE06_RS01135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JHE06_RS01145	COG3711	transcriptional antiterminator
JHE06_RS01160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHE06_RS01165	COG1428	Deoxynucleoside kinase
JHE06_RS01170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHE06_RS01180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JHE06_RS01180	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
JHE06_RS01185	COG4166	transmembrane transport
JHE06_RS01190	COG0371	Dehydrogenase
JHE06_RS01195	COG0667	Aldo Keto reductase
JHE06_RS01205	COG1473	amidohydrolase
JHE06_RS01210	COG1464	Belongs to the NlpA lipoprotein family
JHE06_RS01215	COG1464	Belongs to the NlpA lipoprotein family
JHE06_RS01220	COG2011	ABC-type metal ion transport system permease component
JHE06_RS01225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JHE06_RS01230	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
JHE06_RS01240	COG1764	response to oxidative stress
JHE06_RS01245	COG0367	asparagine synthase
JHE06_RS01250	COG1942	4-Oxalocrotonate Tautomerase
JHE06_RS01255	COG0561	phosphatase activity
JHE06_RS01260	COG1078	dGTPase activity
JHE06_RS01265	COG0095	Lipoate-protein ligase
JHE06_RS01270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JHE06_RS01275	COG0022	dehydrogenase e1 component
JHE06_RS01285	COG3343	RNA polymerase activity
JHE06_RS01290	COG0504	CTP synthase activity
JHE06_RS01300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JHE06_RS01305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JHE06_RS01310	COG0254	rRNA binding
JHE06_RS01315	COG1704	LemA family
JHE06_RS01320	COG0501	Belongs to the peptidase M48B family
JHE06_RS01330	COG1181	Belongs to the D-alanine--D-alanine ligase family
JHE06_RS01335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JHE06_RS01340	COG0670	Belongs to the BI1 family
JHE06_RS01345	COG0513	Belongs to the DEAD box helicase family
JHE06_RS01350	COG0736	holo-[acyl-carrier-protein] synthase activity
JHE06_RS01355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHE06_RS01365	COG2337	Toxic component of a toxin-antitoxin (TA) module
JHE06_RS01370	COG4708	membrane
JHE06_RS01415	COG0604	alcohol dehydrogenase
JHE06_RS01420	COG2388	GCN5-related N-acetyl-transferase
JHE06_RS01445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHE06_RS01450	COG1288	antiporter activity
JHE06_RS01470	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JHE06_RS01475	COG4856	YbbR-like protein
JHE06_RS01480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHE06_RS01485	COG0753	catalase activity
JHE06_RS01515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHE06_RS01545	COG3682	Transcriptional regulator
JHE06_RS01565	COG1268	BioY protein
JHE06_RS01575	COG0110	maltose O-acetyltransferase activity
JHE06_RS01580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JHE06_RS01585	COG2076	Multidrug Resistance protein
JHE06_RS01590	COG2076	Multidrug Resistance protein
JHE06_RS01600	COG0590	tRNA wobble adenosine to inosine editing
JHE06_RS01605	COG0803	Belongs to the bacterial solute-binding protein 9 family
JHE06_RS01620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JHE06_RS01625	COG1902	pentaerythritol trinitrate reductase activity
JHE06_RS01630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHE06_RS01645	COG1011	Hydrolase
JHE06_RS01655	COG2824	Alkylphosphonate utilization operon protein PhnA
JHE06_RS01660	COG0737	Belongs to the 5'-nucleotidase family
JHE06_RS01680	COG0628	permease
JHE06_RS01700	COG0702	epimerase
JHE06_RS01705	COG1757	Na H antiporter
JHE06_RS01710	COG0686	Belongs to the AlaDH PNT family
JHE06_RS01715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JHE06_RS01720	COG2213	PTS system mannitol-specific
JHE06_RS01725	COG3711	transcriptional antiterminator
JHE06_RS01730	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHE06_RS01735	COG0246	Mannitol dehydrogenase
JHE06_RS01750	COG0405	Gamma-glutamyltransferase
JHE06_RS01755	COG1929	Belongs to the glycerate kinase type-1 family
JHE06_RS01765	COG0205	6-phosphofructokinase activity
JHE06_RS01770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JHE06_RS01775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHE06_RS01790	COG1609	Transcriptional regulator
JHE06_RS01795	COG0564	pseudouridine synthase activity
JHE06_RS01810	COG1214	PFAM Peptidase M22, glycoprotease
JHE06_RS01820	COG1214	PFAM Peptidase M22, glycoprotease
JHE06_RS01820	COG0456	acetyltransferase
JHE06_RS01825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JHE06_RS01835	COG0488	(ABC) transporter
JHE06_RS01850	COG1266	CAAX protease self-immunity
JHE06_RS01855	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JHE06_RS01860	COG0459	protein refolding
JHE06_RS01885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JHE06_RS01895	COG0463	Glycosyl transferase, family 2
JHE06_RS01900	COG1368	sulfuric ester hydrolase activity
JHE06_RS01905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JHE06_RS01915	COG2188	Transcriptional regulator
JHE06_RS01920	COG1316	TRANSCRIPTIONal
JHE06_RS01925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JHE06_RS01930	COG1316	TRANSCRIPTIONal
JHE06_RS01935	COG1739	Uncharacterized protein family UPF0029
JHE06_RS01940	COG1307	EDD domain protein, DegV family
JHE06_RS01945	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JHE06_RS01950	COG1040	competence protein
JHE06_RS01960	COG0653	protein targeting
JHE06_RS01970	COG2884	Cell division ATP-binding protein ftsE
JHE06_RS01975	COG2177	Part of the ABC transporter FtsEX involved in
JHE06_RS01980	COG3103	Sh3 type 3 domain protein
JHE06_RS01980	COG0791	NLP P60 protein
JHE06_RS01980	COG1388	LysM domain
JHE06_RS01985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHE06_RS01990	COG0745	RESPONSE REGULATOR receiver
JHE06_RS01995	COG5002	protein histidine kinase activity
JHE06_RS02000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JHE06_RS02005	COG0573	inorganic phosphate transmembrane transporter activity
JHE06_RS02010	COG0581	inorganic phosphate transmembrane transporter activity
JHE06_RS02015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHE06_RS02020	COG0704	Plays a role in the regulation of phosphate uptake
JHE06_RS02025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JHE06_RS02030	COG0573	inorganic phosphate transmembrane transporter activity
JHE06_RS02035	COG0581	inorganic phosphate transmembrane transporter activity
JHE06_RS02040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHE06_RS02045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHE06_RS02050	COG0704	Plays a role in the regulation of phosphate uptake
JHE06_RS02055	COG0640	Transcriptional regulator
JHE06_RS02065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JHE06_RS02075	COG1983	PspC domain protein
JHE06_RS02080	COG1950	PFAM Membrane protein of
JHE06_RS02090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JHE06_RS02095	COG0546	phosphoglycolate phosphatase activity
JHE06_RS02100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JHE06_RS02115	COG0492	ferredoxin-NADP+ reductase activity
JHE06_RS02120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHE06_RS02125	COG1660	Displays ATPase and GTPase activities
JHE06_RS02135	COG1481	regulation of sporulation
JHE06_RS02140	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
JHE06_RS02150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHE06_RS02155	COG0740	serine-type endopeptidase activity
JHE06_RS02175	COG0126	phosphoglycerate kinase activity
JHE06_RS02180	COG0149	triose-phosphate isomerase activity
JHE06_RS02195	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JHE06_RS02195	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JHE06_RS02200	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHE06_RS02200	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS02210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHE06_RS02220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JHE06_RS02230	COG0557	exoribonuclease II activity
JHE06_RS02235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JHE06_RS02240	COG0386	Belongs to the glutathione peroxidase family
JHE06_RS02245	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JHE06_RS02255	COG0561	phosphatase activity
JHE06_RS02280	COG4895	conserved protein (DUF2196)
JHE06_RS02285	COG0686	Belongs to the AlaDH PNT family
JHE06_RS02295	COG2390	Transcriptional regulator
JHE06_RS02300	COG0738	Major facilitator superfamily
JHE06_RS02315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JHE06_RS02325	COG1295	ribonuclease BN
JHE06_RS02330	COG0772	Belongs to the SEDS family
JHE06_RS02335	COG1393	Belongs to the ArsC family
JHE06_RS02345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JHE06_RS02350	COG2011	ABC-type metal ion transport system permease component
JHE06_RS02355	COG1464	Belongs to the NlpA lipoprotein family
JHE06_RS02360	COG3402	PFAM membrane-flanked domain
JHE06_RS02370	COG3402	PFAM membrane-flanked domain
JHE06_RS02375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JHE06_RS02385	COG0719	Fe-S assembly protein
JHE06_RS02390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JHE06_RS02400	COG0719	Fe-S assembly protein
JHE06_RS02435	COG1609	Transcriptional regulator
JHE06_RS02455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHE06_RS02490	COG3715	PTS system
JHE06_RS02495	COG3716	PTS system mannose fructose sorbose family IID component
JHE06_RS02540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHE06_RS02540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHE06_RS02545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JHE06_RS02555	COG3173	Aminoglycoside phosphotransferase
JHE06_RS02570	COG1129	ABC transporter
JHE06_RS02575	COG2135	peptidase activity
JHE06_RS02590	COG0656	L-ascorbic acid biosynthetic process
JHE06_RS02605	COG3588	fructose-bisphosphate aldolase
JHE06_RS02615	COG0765	amino acid transport
JHE06_RS02620	COG0765	amino acid transport
JHE06_RS02625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHE06_RS02630	COG1126	abc transporter atp-binding protein
JHE06_RS02635	COG0737	Belongs to the 5'-nucleotidase family
JHE06_RS02640	COG4470	Protein conserved in bacteria
JHE06_RS02645	COG0647	UMP catabolic process
JHE06_RS02660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JHE06_RS02665	COG0492	ferredoxin-NADP+ reductase activity
JHE06_RS02670	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
JHE06_RS02675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHE06_RS02680	COG1940	carbohydrate kinase activity
JHE06_RS02685	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JHE06_RS02690	COG1098	S1 RNA binding domain
JHE06_RS02700	COG0166	Belongs to the GPI family
JHE06_RS02855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JHE06_RS02860	COG0477	Major facilitator Superfamily
JHE06_RS02865	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JHE06_RS02870	COG0671	phosphoesterase, PA-phosphatase related
JHE06_RS02890	COG1388	LysM domain
JHE06_RS02890	COG1705	Flagellar rod assembly protein muramidase FlgJ
JHE06_RS02890	COG1388	LysM domain
JHE06_RS02890	COG1705	Flagellar rod assembly protein muramidase FlgJ
JHE06_RS02895	COG1263	PTS System
JHE06_RS02895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS02900	COG0495	leucyl-tRNA aminoacylation
JHE06_RS02905	COG2244	polysaccharide biosynthetic process
JHE06_RS02910	COG1187	pseudouridine synthase activity
JHE06_RS02915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JHE06_RS02920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHE06_RS02930	COG0577	efflux transmembrane transporter activity
JHE06_RS02935	COG1136	(ABC) transporter
JHE06_RS02945	COG1473	amidohydrolase
JHE06_RS02950	COG1473	amidohydrolase
JHE06_RS02955	COG0601	transmembrane transport
JHE06_RS02960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHE06_RS02970	COG0444	Belongs to the ABC transporter superfamily
JHE06_RS02975	COG4608	Belongs to the ABC transporter superfamily
JHE06_RS02980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHE06_RS03010	COG0419	ATPase involved in DNA repair
JHE06_RS03020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHE06_RS03035	COG0346	lactoylglutathione lyase activity
JHE06_RS03040	COG1733	regulation of RNA biosynthetic process
JHE06_RS03045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JHE06_RS03050	COG0072	phenylalanine-tRNA ligase activity
JHE06_RS03050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHE06_RS03055	COG0531	amino acid
JHE06_RS03060	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JHE06_RS03070	COG1286	toxin biosynthetic process
JHE06_RS03075	COG1193	negative regulation of DNA recombination
JHE06_RS03080	COG3118	belongs to the thioredoxin family
JHE06_RS03095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JHE06_RS03110	COG4152	abc transporter atp-binding protein
JHE06_RS03115	COG1668	transmembrane transport
JHE06_RS03120	COG1719	4-vinyl reductase, 4VR
JHE06_RS03135	COG0622	Phosphoesterase
JHE06_RS03140	COG0517	IMP dehydrogenase activity
JHE06_RS03145	COG2814	Major facilitator Superfamily
JHE06_RS03150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JHE06_RS03155	COG0668	transmembrane transport
JHE06_RS03165	COG4980	gas vesicle protein
JHE06_RS03170	COG0006	proline dipeptidase activity
JHE06_RS03175	COG1609	Transcriptional regulator
JHE06_RS03190	COG4120	Belongs to the binding-protein-dependent transport system permease family
JHE06_RS03195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JHE06_RS03200	COG1054	Belongs to the UPF0176 family
JHE06_RS03205	COG0519	Catalyzes the synthesis of GMP from XMP
JHE06_RS03210	COG3103	Sh3 type 3 domain protein
JHE06_RS03210	COG0791	NLP P60 protein
JHE06_RS03210	COG1388	LysM domain
JHE06_RS03215	COG1597	lipid kinase activity
JHE06_RS03225	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JHE06_RS03235	COG0217	transcriptional regulatory protein
JHE06_RS03240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHE06_RS03245	COG1459	type II secretion system
JHE06_RS03250	COG4537	Required for transformation and DNA binding
JHE06_RS03275	COG0006	proline dipeptidase activity
JHE06_RS03285	COG1302	Protein conserved in bacteria
JHE06_RS03290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHE06_RS03295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JHE06_RS03300	COG1570	exodeoxyribonuclease VII activity
JHE06_RS03305	COG1722	exodeoxyribonuclease VII activity
JHE06_RS03315	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
JHE06_RS03320	COG1438	arginine binding
JHE06_RS03325	COG0497	DNA recombination
JHE06_RS03340	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHE06_RS03345	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JHE06_RS03350	COG0745	RESPONSE REGULATOR receiver
JHE06_RS03355	COG5002	protein histidine kinase activity
JHE06_RS03360	COG0706	membrane insertase activity
JHE06_RS03365	COG1254	Belongs to the acylphosphatase family
JHE06_RS03375	COG0551	DNA topoisomerase type I activity
JHE06_RS03375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHE06_RS03380	COG1674	ftsk spoiiie
JHE06_RS03380	COG1280	lysine exporter protein (LysE YggA)
JHE06_RS03385	COG1744	ABC transporter substrate-binding protein PnrA-like
JHE06_RS03390	COG3845	ABC transporter
JHE06_RS03395	COG4603	Belongs to the binding-protein-dependent transport system permease family
JHE06_RS03400	COG1079	Belongs to the binding-protein-dependent transport system permease family
JHE06_RS03405	COG0612	Peptidase, M16
JHE06_RS03410	COG0612	Peptidase, M16
JHE06_RS03420	COG1426	Protein conserved in bacteria
JHE06_RS03425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JHE06_RS03435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JHE06_RS03440	COG1418	mRNA catabolic process
JHE06_RS03445	COG1692	metallophosphoesterase
JHE06_RS03450	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JHE06_RS03455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JHE06_RS03465	COG0632	four-way junction helicase activity
JHE06_RS03470	COG2255	four-way junction helicase activity
JHE06_RS03475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JHE06_RS03480	COG0343	queuine tRNA-ribosyltransferase activity
JHE06_RS03485	COG1862	Preprotein translocase
JHE06_RS03495	COG1454	alcohol dehydrogenase
JHE06_RS03495	COG1012	belongs to the aldehyde dehydrogenase family
JHE06_RS03510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JHE06_RS03515	COG4109	DRTGG domain
JHE06_RS03520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JHE06_RS03525	COG1253	flavin adenine dinucleotide binding
JHE06_RS03530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHE06_RS03535	COG3679	Belongs to the UPF0342 family
JHE06_RS03540	COG0420	3'-5' exonuclease activity
JHE06_RS03545	COG4717	serine-type aminopeptidase activity
JHE06_RS03565	COG0537	adenosine 5'-monophosphoramidase activity
JHE06_RS03570	COG1131	(ABC) transporter
JHE06_RS03575	COG4473	ABC transporter
JHE06_RS03585	COG2814	Major facilitator Superfamily
JHE06_RS03590	COG0510	thiamine kinase activity
JHE06_RS03595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JHE06_RS03605	COG1363	Peptidase, m42
JHE06_RS03610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JHE06_RS03615	COG0589	response to stress
JHE06_RS03620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHE06_RS03630	COG1674	ftsk spoiiie
JHE06_RS03635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHE06_RS03640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHE06_RS03640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHE06_RS03645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JHE06_RS03650	COG0237	dephospho-CoA kinase activity
JHE06_RS03665	COG1484	DNA-dependent DNA replication
JHE06_RS03670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JHE06_RS03675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JHE06_RS03680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JHE06_RS03685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JHE06_RS03690	COG4166	transmembrane transport
JHE06_RS03695	COG4166	transmembrane transport
JHE06_RS03700	COG1363	Peptidase, m42
JHE06_RS03705	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JHE06_RS03710	COG1234	tRNA 3'-trailer cleavage
JHE06_RS03715	COG0095	Lipoate-protein ligase
JHE06_RS03720	COG0180	Tryptophanyl-tRNA synthetase
JHE06_RS03730	COG0601	transmembrane transport
JHE06_RS03735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHE06_RS03740	COG0444	Belongs to the ABC transporter superfamily
JHE06_RS03745	COG4608	Belongs to the ABC transporter superfamily
JHE06_RS03750	COG1393	Belongs to the ArsC family
JHE06_RS03755	COG4862	establishment of competence for transformation
JHE06_RS03765	COG1164	Oligoendopeptidase f
JHE06_RS03775	COG4116	CYTH
JHE06_RS03780	COG2357	RelA SpoT domain protein
JHE06_RS03790	COG0564	pseudouridine synthase activity
JHE06_RS03795	COG2239	Acts as a magnesium transporter
JHE06_RS03800	COG2333	competence protein COMEC
JHE06_RS03800	COG0658	competence protein
JHE06_RS03815	COG1363	Peptidase, m42
JHE06_RS03820	COG0628	permease
JHE06_RS03825	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHE06_RS03835	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JHE06_RS03850	COG0542	response to heat
JHE06_RS03865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHE06_RS03870	COG0438	transferase activity, transferring glycosyl groups
JHE06_RS03875	COG0438	transferase activity, transferring glycosyl groups
JHE06_RS03880	COG2084	Dehydrogenase
JHE06_RS03885	COG4703	Protein of unknown function (DUF1797)
JHE06_RS03890	COG0460	homoserine dehydrogenase
JHE06_RS03900	COG0083	homoserine kinase activity
JHE06_RS03905	COG3142	Participates in the control of copper homeostasis
JHE06_RS03910	COG0527	aspartate kinase activity
JHE06_RS03915	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JHE06_RS03920	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JHE06_RS03925	COG1534	Rna-binding protein
JHE06_RS03930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JHE06_RS03935	COG1713	HD superfamily hydrolase involved in NAD metabolism
JHE06_RS03940	COG0799	negative regulation of ribosome biogenesis
JHE06_RS03945	COG2226	methyltransferase
JHE06_RS03950	COG0514	ATP-dependent DNA helicase (RecQ)
JHE06_RS03955	COG1323	Belongs to the UPF0348 family
JHE06_RS03965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JHE06_RS03975	COG2001	Belongs to the MraZ family
JHE06_RS03980	COG0275	rRNA processing
JHE06_RS03985	COG4839	cell division protein FtsL
JHE06_RS03990	COG0768	penicillin binding
JHE06_RS03995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JHE06_RS04005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JHE06_RS04010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JHE06_RS04025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JHE06_RS04030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JHE06_RS04040	COG0762	integral membrane protein
JHE06_RS04045	COG2302	S4 RNA-binding domain
JHE06_RS04050	COG3599	regulation of cell shape
JHE06_RS04055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JHE06_RS04075	COG2261	transglycosylase associated protein
JHE06_RS04085	COG1328	CTP reductase activity
JHE06_RS04090	COG3853	Toxic anion resistance protein (TelA)
JHE06_RS04100	COG0494	nUDIX hydrolase
JHE06_RS04110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHE06_RS04120	COG5506	Protein of unknown function (DUF1694)
JHE06_RS04125	COG4493	Belongs to the UPF0637 family
JHE06_RS04155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JHE06_RS04160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JHE06_RS04165	COG1956	GAF domain-containing protein
JHE06_RS04170	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JHE06_RS04175	COG1104	cysteine desulfurase activity
JHE06_RS04180	COG0301	tRNA thio-modification
JHE06_RS04185	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JHE06_RS04195	COG0525	valine-tRNA ligase activity
JHE06_RS04200	COG0285	dihydrofolate synthase activity
JHE06_RS04205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHE06_RS04210	COG2003	Belongs to the UPF0758 family
JHE06_RS04215	COG1278	Cold shock
JHE06_RS04220	COG1278	Cold shock
JHE06_RS04225	COG1278	Cold shock
JHE06_RS04235	COG1278	Cold shock
JHE06_RS04240	COG1077	Cell shape determining protein MreB Mrl
JHE06_RS04245	COG1792	Involved in formation and maintenance of cell shape
JHE06_RS04260	COG2894	cell division
JHE06_RS04270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHE06_RS04275	COG0765	amino acid transport
JHE06_RS04280	COG1126	abc transporter atp-binding protein
JHE06_RS04285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JHE06_RS04295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JHE06_RS04305	COG0827	DNA restriction-modification system
JHE06_RS04310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JHE06_RS04315	COG3973	AAA domain
JHE06_RS04335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JHE06_RS04345	COG1346	cytolysis
JHE06_RS04360	COG1181	Belongs to the D-alanine--D-alanine ligase family
JHE06_RS04360	COG2918	glutathione biosynthetic process
JHE06_RS04365	COG1104	cysteine desulfurase activity
JHE06_RS04375	COG0482	sulfurtransferase activity
JHE06_RS04385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JHE06_RS04390	COG1597	lipid kinase activity
JHE06_RS04395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JHE06_RS04400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHE06_RS04405	COG4472	Bacterial protein of unknown function (DUF965)
JHE06_RS04410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JHE06_RS04415	COG3906	Belongs to the UPF0473 family
JHE06_RS04420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JHE06_RS04425	COG0572	uridine kinase
JHE06_RS04430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHE06_RS04440	COG4585	Histidine kinase
JHE06_RS04445	COG2197	response regulator
JHE06_RS04450	COG4841	protein insertion into membrane
JHE06_RS04460	COG5503	Protein of unknown function (DUF1447)
JHE06_RS04470	COG1132	(ABC) transporter
JHE06_RS04475	COG0561	phosphatase activity
JHE06_RS04485	COG0242	peptide deformylase activity
JHE06_RS04490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JHE06_RS04505	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHE06_RS04515	COG0039	L-malate dehydrogenase activity
JHE06_RS04520	COG4476	Belongs to the UPF0223 family
JHE06_RS04525	COG0483	inositol monophosphate 1-phosphatase activity
JHE06_RS04530	COG1217	gtp-binding protein TYPA
JHE06_RS04535	COG0772	Belongs to the SEDS family
JHE06_RS04540	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JHE06_RS04550	COG4471	UPF0298 protein
JHE06_RS04555	COG0742	ribosomal rna small subunit methyltransferase
JHE06_RS04560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JHE06_RS04565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHE06_RS04575	COG1555	photosystem II stabilization
JHE06_RS04575	COG1596	polysaccharide export
JHE06_RS04580	COG2131	deaminase
JHE06_RS04585	COG0658	competence protein
JHE06_RS04585	COG2333	competence protein COMEC
JHE06_RS04590	COG1466	dna polymerase III delta subunit
JHE06_RS04595	COG0268	Binds directly to 16S ribosomal RNA
JHE06_RS04600	COG0556	nucleotide-excision repair
JHE06_RS04605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JHE06_RS04610	COG1185	polyribonucleotide nucleotidyltransferase activity
JHE06_RS04620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JHE06_RS04625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHE06_RS04645	COG0517	IMP dehydrogenase activity
JHE06_RS04645	COG4175	Glycine betaine
JHE06_RS04650	COG1418	mRNA catabolic process
JHE06_RS04655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHE06_RS04665	COG3859	Proton-coupled thiamine transporter YuaJ
JHE06_RS04710	COG1269	ATP hydrolysis coupled proton transport
JHE06_RS04715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JHE06_RS04725	COG1527	subunit (C
JHE06_RS04730	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
JHE06_RS04735	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
JHE06_RS04740	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
JHE06_RS04745	COG1394	ATPase activity, coupled to movement of substances
JHE06_RS04760	COG0194	GDP metabolic process
JHE06_RS04765	COG1758	RNA polymerase activity
JHE06_RS04770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JHE06_RS04775	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JHE06_RS04785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHE06_RS04790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHE06_RS04790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JHE06_RS04800	COG0515	serine threonine protein kinase
JHE06_RS04800	COG2815	serine threonine protein kinase
JHE06_RS04805	COG1162	GTPase activity
JHE06_RS04810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JHE06_RS04815	COG1564	THIamine pyrophosphokinase
JHE06_RS04820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JHE06_RS04830	COG1461	Dihydroxyacetone kinase
JHE06_RS04835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JHE06_RS04840	COG0416	fatty acid biosynthetic process
JHE06_RS04845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHE06_RS04855	COG4608	Belongs to the ABC transporter superfamily
JHE06_RS04860	COG0601	transmembrane transport
JHE06_RS04875	COG0571	ribonuclease III activity
JHE06_RS04880	COG1196	nuclear chromosome segregation
JHE06_RS04885	COG0561	phosphatase activity
JHE06_RS04890	COG0552	protein localization to endoplasmic reticulum
JHE06_RS04900	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JHE06_RS04905	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JHE06_RS04910	COG0228	four-way junction DNA binding
JHE06_RS04915	COG1837	Belongs to the UPF0109 family
JHE06_RS04920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JHE06_RS04925	COG0336	Belongs to the RNA methyltransferase TrmD family
JHE06_RS04930	COG0335	large ribosomal subunit rRNA binding
JHE06_RS04955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JHE06_RS04960	COG0561	phosphatase activity
JHE06_RS04965	COG1073	alpha beta
JHE06_RS04970	COG2151	metal-sulfur cluster biosynthetic enzyme
JHE06_RS04980	COG0542	response to heat
JHE06_RS04990	COG0587	DNA-directed DNA polymerase activity
JHE06_RS04995	COG0205	6-phosphofructokinase activity
JHE06_RS05005	COG2996	Protein conserved in bacteria
JHE06_RS05010	COG0735	belongs to the Fur family
JHE06_RS05020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JHE06_RS05040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JHE06_RS05045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JHE06_RS05050	COG1187	pseudouridine synthase activity
JHE06_RS05055	COG0745	RESPONSE REGULATOR receiver
JHE06_RS05060	COG5002	protein histidine kinase activity
JHE06_RS05065	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
JHE06_RS05075	COG0514	ATP-dependent DNA helicase (RecQ)
JHE06_RS05080	COG0791	NLP P60 protein
JHE06_RS05080	COG1388	LysM domain
JHE06_RS05080	COG3103	Sh3 type 3 domain protein
JHE06_RS05090	COG0539	negative regulation of cytoplasmic translation
JHE06_RS05095	COG1160	GTP binding
JHE06_RS05110	COG0457	Tetratricopeptide repeat
JHE06_RS05115	COG5582	Belongs to the UPF0302 family
JHE06_RS05120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JHE06_RS05125	COG0617	tRNA 3'-terminal CCA addition
JHE06_RS05140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHE06_RS05140	COG1199	ATP-dependent helicase activity
JHE06_RS05155	COG3935	DnaD domain protein
JHE06_RS05160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JHE06_RS05165	COG4499	WXG100 protein secretion system (Wss), protein YukC
JHE06_RS05165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHE06_RS05170	COG3331	DNA recombination
JHE06_RS05175	COG4474	Belongs to the UPF0398 family
JHE06_RS05180	COG3599	regulation of cell shape
JHE06_RS05190	COG0116	Belongs to the methyltransferase superfamily
JHE06_RS05205	COG0582	viral genome integration into host DNA
JHE06_RS05220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHE06_RS05390	COG0740	serine-type endopeptidase activity
JHE06_RS05485	COG1705	Flagellar rod assembly protein muramidase FlgJ
JHE06_RS05520	COG1846	Transcriptional regulator
JHE06_RS05525	COG0400	carboxylic ester hydrolase activity
JHE06_RS05540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHE06_RS05545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHE06_RS05555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JHE06_RS05565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHE06_RS05570	COG0511	ligase activity, forming carbon-carbon bonds
JHE06_RS05575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHE06_RS05580	COG0439	Biotin carboxylase
JHE06_RS05585	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JHE06_RS05590	COG0825	malonyl-CoA metabolic process
JHE06_RS05600	COG0544	peptidyl-prolyl cis-trans isomerase activity
JHE06_RS05605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JHE06_RS05610	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JHE06_RS05625	COG0765	amino acid transport
JHE06_RS05635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHE06_RS05635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHE06_RS05635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHE06_RS05640	COG1105	Belongs to the carbohydrate kinase PfkB family
JHE06_RS05645	COG1349	DNA-binding transcription factor activity
JHE06_RS05650	COG1725	Transcriptional regulator
JHE06_RS05660	COG0287	Prephenate dehydrogenase
JHE06_RS05665	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JHE06_RS05670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JHE06_RS05675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JHE06_RS05680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JHE06_RS05685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JHE06_RS05690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JHE06_RS05695	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JHE06_RS05700	COG1605	Chorismate mutase
JHE06_RS05700	COG0077	Prephenate dehydratase
JHE06_RS05705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHE06_RS05710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JHE06_RS05715	COG1234	tRNA 3'-trailer cleavage
JHE06_RS05720	COG0300	oxidoreductase activity
JHE06_RS05725	COG5416	Lipopolysaccharide assembly protein A domain
JHE06_RS05735	COG2239	Acts as a magnesium transporter
JHE06_RS05750	COG1307	EDD domain protein, DegV family
JHE06_RS05755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JHE06_RS05755	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JHE06_RS05760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JHE06_RS05765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHE06_RS05780	COG3763	UPF0154 protein
JHE06_RS05785	COG1132	(ABC) transporter
JHE06_RS05790	COG1132	(ABC) transporter
JHE06_RS05795	COG0204	Acyl-transferase
JHE06_RS05800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JHE06_RS05810	COG0052	Belongs to the universal ribosomal protein uS2 family
JHE06_RS05815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JHE06_RS05820	COG0528	UMP kinase activity
JHE06_RS05825	COG0233	cytoplasmic translational termination
JHE06_RS05835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JHE06_RS05840	COG4589	Belongs to the CDS family
JHE06_RS05845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JHE06_RS05850	COG0750	zinc metalloprotease
JHE06_RS05855	COG0442	prolyl-tRNA aminoacylation
JHE06_RS05860	COG2176	DNA-directed DNA polymerase activity
JHE06_RS05865	COG0779	Required for maturation of 30S ribosomal subunits
JHE06_RS05870	COG0195	Participates in both transcription termination and antitermination
JHE06_RS05875	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JHE06_RS05890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JHE06_RS05900	COG1307	EDD domain protein, DegV family
JHE06_RS05905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JHE06_RS05910	COG0196	riboflavin kinase activity
JHE06_RS05925	COG1420	regulation of RNA biosynthetic process
JHE06_RS05930	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JHE06_RS05935	COG0443	Heat shock 70 kDa protein
JHE06_RS05940	COG0484	heat shock protein binding
JHE06_RS05945	COG0481	GTPase activity
JHE06_RS05965	COG0436	Aminotransferase
JHE06_RS05970	COG2094	Belongs to the DNA glycosylase MPG family
JHE06_RS05980	COG2264	protein methyltransferase activity
JHE06_RS05985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JHE06_RS05990	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JHE06_RS05995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHE06_RS06000	COG1490	D-aminoacyl-tRNA deacylase activity
JHE06_RS06005	COG0860	N-Acetylmuramoyl-L-alanine amidase
JHE06_RS06005	COG3103	Sh3 type 3 domain protein
JHE06_RS06005	COG4991	sh3 domain protein
JHE06_RS06010	COG0124	histidyl-tRNA synthetase
JHE06_RS06015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JHE06_RS06025	COG1714	RDD family
JHE06_RS06030	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JHE06_RS06040	COG1704	LemA family
JHE06_RS06050	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JHE06_RS06055	COG0735	belongs to the Fur family
JHE06_RS06065	COG1610	YqeY-like protein
JHE06_RS06070	COG1702	phosphate starvation-inducible protein PhoH
JHE06_RS06080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JHE06_RS06085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JHE06_RS06095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JHE06_RS06100	COG1381	Involved in DNA repair and RecF pathway recombination
JHE06_RS06105	COG0752	glycyl-tRNA synthetase alpha subunit
JHE06_RS06110	COG0751	glycine-tRNA ligase activity
JHE06_RS06115	COG3189	MarR family transcriptional regulator
JHE06_RS06120	COG1132	(ABC) transporter
JHE06_RS06130	COG1827	regulation of RNA biosynthetic process
JHE06_RS06140	COG0358	DNA primase activity
JHE06_RS06145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JHE06_RS06155	COG2384	SAM-dependent methyltransferase
JHE06_RS06160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JHE06_RS06165	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHE06_RS06175	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JHE06_RS06180	COG1074	ATP-dependent DNA helicase activity
JHE06_RS06210	COG0564	pseudouridine synthase activity
JHE06_RS06220	COG0540	Belongs to the ATCase OTCase family
JHE06_RS06225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JHE06_RS06230	COG0505	Belongs to the CarA family
JHE06_RS06235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JHE06_RS06255	COG2807	transmembrane transport
JHE06_RS06280	COG4120	Belongs to the binding-protein-dependent transport system permease family
JHE06_RS06285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHE06_RS06285	COG1116	anion transmembrane transporter activity
JHE06_RS06300	COG0693	protein deglycase activity
JHE06_RS06325	COG2321	neutral zinc metallopeptidase
JHE06_RS06330	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JHE06_RS06335	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JHE06_RS06340	COG1227	inorganic diphosphatase activity
JHE06_RS06345	COG0583	DNA-binding transcription factor activity
JHE06_RS06350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHE06_RS06355	COG1882	Formate acetyltransferase
JHE06_RS06360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JHE06_RS06365	COG0187	DNA topoisomerase II activity
JHE06_RS06380	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JHE06_RS06385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JHE06_RS06390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JHE06_RS06395	COG4974	Belongs to the 'phage' integrase family
JHE06_RS06400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHE06_RS06405	COG0758	DNA mediated transformation
JHE06_RS06420	COG0681	Belongs to the peptidase S26 family
JHE06_RS06425	COG0681	Belongs to the peptidase S26 family
JHE06_RS06430	COG3409	Peptidoglycan-binding domain 1 protein
JHE06_RS06430	COG0793	Belongs to the peptidase S41A family
JHE06_RS06440	COG4479	Belongs to the UPF0346 family
JHE06_RS06445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHE06_RS06455	COG2755	lipolytic protein G-D-S-L family
JHE06_RS06460	COG1307	EDD domain protein, DegV family
JHE06_RS06465	COG1272	protein, Hemolysin III
JHE06_RS06475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JHE06_RS06480	COG0488	(ABC) transporter
JHE06_RS06490	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JHE06_RS06495	COG1278	Cold shock
JHE06_RS06505	COG0328	RNA-DNA hybrid ribonuclease activity
JHE06_RS06515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHE06_RS06520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHE06_RS06525	COG1780	Probably involved in ribonucleotide reductase function
JHE06_RS06540	COG1395	domain, Protein
JHE06_RS06550	COG0789	Transcriptional regulator
JHE06_RS06560	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JHE06_RS06565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JHE06_RS06570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JHE06_RS06575	COG0584	glycerophosphoryl diester phosphodiesterase
JHE06_RS06580	COG0166	Belongs to the GPI family
JHE06_RS06595	COG1940	carbohydrate kinase activity
JHE06_RS06605	COG0457	Tetratricopeptide repeat
JHE06_RS06605	COG0705	Rhomboid family
JHE06_RS06615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JHE06_RS06620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JHE06_RS06635	COG0768	penicillin binding
JHE06_RS06650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JHE06_RS06660	COG0513	Belongs to the DEAD box helicase family
JHE06_RS06665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JHE06_RS06680	COG1438	arginine binding
JHE06_RS06685	COG0018	arginyl-trna synthetase
JHE06_RS06690	COG1744	ABC transporter substrate-binding protein PnrA-like
JHE06_RS06695	COG2252	PERMEase
JHE06_RS06700	COG1937	Protein conserved in bacteria
JHE06_RS06705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHE06_RS06710	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHE06_RS06715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHE06_RS06720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JHE06_RS06725	COG1132	(ABC) transporter
JHE06_RS06730	COG1132	(ABC) transporter
JHE06_RS06735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JHE06_RS06740	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JHE06_RS06755	COG4876	unkown
JHE06_RS06780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHE06_RS06785	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JHE06_RS06790	COG4770	biotin carboxylase activity
JHE06_RS06800	COG0511	ligase activity, forming carbon-carbon bonds
JHE06_RS06800	COG5016	pyruvate
JHE06_RS06885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHE06_RS06890	COG2188	Transcriptional regulator
JHE06_RS06895	COG2723	6-phospho-beta-galactosidase activity
JHE06_RS06900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS06910	COG0583	DNA-binding transcription factor activity
JHE06_RS06990	COG0366	Alpha amylase catalytic
JHE06_RS06995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHE06_RS07010	COG3833	ABC-type maltose transport systems, permease component
JHE06_RS07015	COG1175	transmembrane transport
JHE06_RS07020	COG2182	Extracellular solute-binding protein
JHE06_RS07025	COG2182	Extracellular solute-binding protein
JHE06_RS07035	COG0366	Alpha amylase catalytic
JHE06_RS07040	COG0366	Alpha amylase catalytic
JHE06_RS07050	COG1597	lipid kinase activity
JHE06_RS07055	COG1609	Transcriptional regulator
JHE06_RS07060	COG0735	belongs to the Fur family
JHE06_RS07065	COG4129	membrane
JHE06_RS07075	COG3557	Belongs to the UPF0374 family
JHE06_RS07080	COG1194	a g-specific adenine glycosylase
JHE06_RS07085	COG2137	regulation of response to DNA damage stimulus
JHE06_RS07090	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
JHE06_RS07095	COG1028	Short-chain dehydrogenase reductase Sdr
JHE06_RS07105	COG1428	Deoxynucleoside kinase
JHE06_RS07120	COG1215	transferase activity, transferring glycosyl groups
JHE06_RS07125	COG1216	Glycosyl transferase, family 2
JHE06_RS07130	COG0489	protein tyrosine kinase activity
JHE06_RS07135	COG3944	biosynthesis protein
JHE06_RS07165	COG1215	transferase activity, transferring glycosyl groups
JHE06_RS07175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHE06_RS07185	COG0438	transferase activity, transferring glycosyl groups
JHE06_RS07190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JHE06_RS07200	COG2723	6-phospho-beta-galactosidase activity
JHE06_RS07205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS07210	COG2188	Transcriptional regulator
JHE06_RS07215	COG1879	ABC-type sugar transport system periplasmic component
JHE06_RS07220	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHE06_RS07225	COG1129	ABC transporter
JHE06_RS07235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHE06_RS07240	COG1609	Transcriptional regulator
JHE06_RS07250	COG0383	alpha-mannosidase activity
JHE06_RS07255	COG2723	6-phospho-beta-galactosidase activity
JHE06_RS07265	COG1609	Transcriptional regulator
JHE06_RS07270	COG2207	Transcriptional regulator
JHE06_RS07270	COG4753	response regulator
JHE06_RS07275	COG2972	Histidine kinase
JHE06_RS07290	COG1653	transport
JHE06_RS07295	COG0395	ABC-type sugar transport system, permease component
JHE06_RS07300	COG1175	transmembrane transport
JHE06_RS07305	COG3250	beta-galactosidase activity
JHE06_RS07335	COG1301	dicarboxylic acid transport
JHE06_RS07340	COG1953	Uracil, thiamine, allantoin
JHE06_RS07345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JHE06_RS07350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JHE06_RS07355	COG2508	Transcriptional regulator
JHE06_RS07360	COG0549	Belongs to the carbamate kinase family
JHE06_RS07365	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JHE06_RS07370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JHE06_RS07375	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
JHE06_RS07380	COG3257	ureidoglycine aminohydrolase activity
JHE06_RS07385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHE06_RS07400	COG1620	l-lactate permease
JHE06_RS07405	COG3835	regulator
JHE06_RS07410	COG1121	(ABC) transporter
JHE06_RS07415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHE06_RS07425	COG0549	Belongs to the carbamate kinase family
JHE06_RS07440	COG2235	arginine
JHE06_RS07450	COG3764	Sortase (surface protein transpeptidase)
JHE06_RS07455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS07465	COG0577	efflux transmembrane transporter activity
JHE06_RS07465	COG1136	(ABC) transporter
JHE06_RS07470	COG0577	efflux transmembrane transporter activity
JHE06_RS07470	COG1136	(ABC) transporter
JHE06_RS07480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHE06_RS07495	COG0561	phosphatase activity
JHE06_RS07505	COG3579	cysteine-type endopeptidase activity
JHE06_RS07520	COG1175	transmembrane transport
JHE06_RS07530	COG2207	Transcriptional regulator
JHE06_RS07535	COG3279	Response regulator of the LytR AlgR family
JHE06_RS07540	COG3275	phosphorelay sensor kinase activity
JHE06_RS07545	COG4166	transmembrane transport
JHE06_RS07555	COG1136	(ABC) transporter
JHE06_RS07560	COG0642	Histidine kinase
JHE06_RS07565	COG0745	RESPONSE REGULATOR receiver
JHE06_RS07570	COG0697	spore germination
JHE06_RS07575	COG1473	amidohydrolase
JHE06_RS07580	COG1966	Carbon starvation protein
JHE06_RS07585	COG1131	(ABC) transporter
JHE06_RS07595	COG0737	Belongs to the 5'-nucleotidase family
JHE06_RS07665	COG3842	ATPase activity
JHE06_RS07695	COG1737	Transcriptional regulator
JHE06_RS07705	COG1447	Phosphotransferase system cellobiose-specific component IIA
JHE06_RS07725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS07730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS07740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS07745	COG0363	glucosamine-6-phosphate deaminase activity
JHE06_RS07750	COG1486	melibiose metabolic process
JHE06_RS07765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHE06_RS07770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JHE06_RS07775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JHE06_RS07795	COG1705	Flagellar rod assembly protein muramidase FlgJ
JHE06_RS07795	COG1388	LysM domain
JHE06_RS07805	COG3711	transcriptional antiterminator
JHE06_RS07810	COG2723	6-phospho-beta-galactosidase activity
JHE06_RS07830	COG0741	lytic transglycosylase activity
JHE06_RS07830	COG0791	NLP P60 protein
JHE06_RS07835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS07835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHE06_RS07845	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS07850	COG3716	PTS system mannose fructose sorbose family IID component
JHE06_RS07860	COG0371	Dehydrogenase
JHE06_RS07865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHE06_RS07870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JHE06_RS07875	COG1737	Transcriptional regulator
JHE06_RS07880	COG0561	phosphatase activity
JHE06_RS07895	COG4464	protein tyrosine phosphatase activity
JHE06_RS07905	COG4372	Transposase
JHE06_RS07935	COG4584	PFAM Integrase catalytic
JHE06_RS07935	COG2390	Transcriptional regulator
JHE06_RS07940	COG1484	DNA-dependent DNA replication
JHE06_RS07950	COG1216	Glycosyl transferase, family 2
JHE06_RS07950	COG1442	glycosyl transferase family 8
JHE06_RS07965	COG1086	Polysaccharide biosynthesis protein
JHE06_RS07980	COG0438	transferase activity, transferring glycosyl groups
JHE06_RS07995	COG0438	transferase activity, transferring glycosyl groups
JHE06_RS08000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHE06_RS08005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHE06_RS08020	COG0489	protein tyrosine kinase activity
JHE06_RS08025	COG3944	biosynthesis protein
JHE06_RS08035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JHE06_RS08040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHE06_RS08055	COG1368	sulfuric ester hydrolase activity
JHE06_RS08060	COG1316	TRANSCRIPTIONal
JHE06_RS08065	COG0438	transferase activity, transferring glycosyl groups
JHE06_RS08075	COG1705	Flagellar rod assembly protein muramidase FlgJ
JHE06_RS08075	COG1388	LysM domain
JHE06_RS08080	COG1083	cytidylyl-transferase
JHE06_RS08110	COG1216	Glycosyl transferase, family 2
JHE06_RS08110	COG1442	glycosyl transferase family 8
JHE06_RS08115	COG1216	Glycosyl transferase, family 2
JHE06_RS08125	COG1368	sulfuric ester hydrolase activity
JHE06_RS08130	COG0463	Glycosyl transferase, family 2
JHE06_RS08140	COG0463	Glycosyl transferase, family 2
JHE06_RS08150	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JHE06_RS08155	COG2089	acid synthase
JHE06_RS08165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHE06_RS08170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JHE06_RS08175	COG1088	dTDP-glucose 4,6-dehydratase activity
JHE06_RS08180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHE06_RS08190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JHE06_RS08195	COG1216	Glycosyl transferase, family 2
JHE06_RS08195	COG1442	glycosyl transferase family 8
JHE06_RS08200	COG2244	polysaccharide biosynthetic process
JHE06_RS08205	COG1216	Glycosyl transferase, family 2
JHE06_RS08205	COG1442	glycosyl transferase family 8
JHE06_RS08215	COG3274	enterobacterial common antigen metabolic process
JHE06_RS08220	COG0024	Methionine aminopeptidase
JHE06_RS08225	COG0716	FMN binding
JHE06_RS08235	COG2309	aminopeptidase activity
JHE06_RS08245	COG1126	abc transporter atp-binding protein
JHE06_RS08250	COG0765	amino acid transport
JHE06_RS08255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHE06_RS08260	COG1309	transcriptional regulator
JHE06_RS08280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS08290	COG1940	carbohydrate kinase activity
JHE06_RS08315	COG1447	Phosphotransferase system cellobiose-specific component IIA
JHE06_RS08320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS08325	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JHE06_RS08325	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JHE06_RS08330	COG0513	Belongs to the DEAD box helicase family
JHE06_RS08335	COG0673	inositol 2-dehydrogenase activity
JHE06_RS08345	COG0656	L-ascorbic acid biosynthetic process
JHE06_RS08350	COG1408	metallophosphoesterase
JHE06_RS08360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHE06_RS08395	COG0668	transmembrane transport
JHE06_RS08400	COG0534	Mate efflux family protein
JHE06_RS08405	COG0561	phosphatase activity
JHE06_RS08435	COG1442	glycosyl transferase family 8
JHE06_RS08440	COG1550	Protein conserved in bacteria
JHE06_RS08455	COG0726	polysaccharide deacetylase
JHE06_RS08460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHE06_RS08465	COG1597	lipid kinase activity
JHE06_RS08470	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JHE06_RS08475	COG0154	amidase activity
JHE06_RS08490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JHE06_RS08495	COG0210	DNA helicase
JHE06_RS08515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JHE06_RS08520	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JHE06_RS08525	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
JHE06_RS08530	COG2233	PERMEase
JHE06_RS08535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JHE06_RS08540	COG1253	flavin adenine dinucleotide binding
JHE06_RS08545	COG0768	penicillin binding
JHE06_RS08555	COG1705	Flagellar rod assembly protein muramidase FlgJ
JHE06_RS08580	COG0251	oxidation-reduction process
JHE06_RS08590	COG0410	ABC transporter
JHE06_RS08625	COG1476	TRANSCRIPTIONal
JHE06_RS08635	COG0561	phosphatase activity
JHE06_RS08660	COG3684	Belongs to the aldolase LacD family
JHE06_RS08670	COG2222	sugar isomerase
JHE06_RS08680	COG3716	PTS system mannose fructose sorbose family IID component
JHE06_RS08690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS08690	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHE06_RS08705	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
JHE06_RS08725	COG0531	amino acid
JHE06_RS08730	COG4975	Glucose uptake
JHE06_RS08735	COG2081	HI0933 family
JHE06_RS08740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JHE06_RS08745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHE06_RS08755	COG1368	sulfuric ester hydrolase activity
JHE06_RS08760	COG5002	protein histidine kinase activity
JHE06_RS08760	COG3850	Histidine kinase
JHE06_RS08765	COG0745	RESPONSE REGULATOR receiver
JHE06_RS08770	COG0629	single-stranded DNA binding
JHE06_RS08780	COG1077	Cell shape determining protein MreB Mrl
JHE06_RS08785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JHE06_RS08795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JHE06_RS08800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JHE06_RS08805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JHE06_RS08810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JHE06_RS08815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JHE06_RS08820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JHE06_RS08825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JHE06_RS08830	COG0356	it plays a direct role in the translocation of protons across the membrane
JHE06_RS08835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JHE06_RS08845	COG0009	L-threonylcarbamoyladenylate synthase
JHE06_RS08850	COG2890	protein-(glutamine-N5) methyltransferase activity
JHE06_RS08855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JHE06_RS08860	COG1435	thymidine kinase activity
JHE06_RS08865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JHE06_RS08870	COG3442	glutamine amidotransferase
JHE06_RS08875	COG1482	cell wall glycoprotein biosynthetic process
JHE06_RS08885	COG2514	catechol 2,3-dioxygenase activity
JHE06_RS08910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JHE06_RS08915	COG0628	permease
JHE06_RS08930	COG2706	6-phosphogluconolactonase activity
JHE06_RS08935	COG0346	lactoylglutathione lyase activity
JHE06_RS08940	COG0346	lactoylglutathione lyase activity
JHE06_RS08945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JHE06_RS08950	COG2190	(PTS) system
JHE06_RS08950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS08950	COG1263	PTS System
JHE06_RS08955	COG2855	membrane
JHE06_RS08960	COG1968	undecaprenyl-diphosphatase activity
JHE06_RS08965	COG1737	Transcriptional regulator
JHE06_RS08970	COG1263	PTS System
JHE06_RS08970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS08975	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JHE06_RS08985	COG0588	phosphoglycerate mutase activity
JHE06_RS08990	COG2217	Heavy metal translocating P-type atpase
JHE06_RS08995	COG0527	aspartate kinase activity
JHE06_RS09005	COG4166	transmembrane transport
JHE06_RS09010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JHE06_RS09020	COG3103	Sh3 type 3 domain protein
JHE06_RS09020	COG0366	Alpha amylase catalytic
JHE06_RS09025	COG0058	SHG alpha-glucan phosphorylase activity
JHE06_RS09035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHE06_RS09040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHE06_RS09065	COG1030	water channel activity
JHE06_RS09070	COG4864	UPF0365 protein
JHE06_RS09095	COG2096	Adenosyltransferase
JHE06_RS09100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHE06_RS09115	COG0586	Pfam SNARE associated Golgi protein
JHE06_RS09135	COG1253	flavin adenine dinucleotide binding
JHE06_RS09140	COG1653	transport
JHE06_RS09145	COG1175	transmembrane transport
JHE06_RS09150	COG0395	ABC-type sugar transport system, permease component
JHE06_RS09175	COG1511	domain protein
JHE06_RS09175	COG1511	domain protein
JHE06_RS09180	COG1959	2 iron, 2 sulfur cluster binding
JHE06_RS09185	COG0277	FAD linked oxidase domain protein
JHE06_RS09195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHE06_RS09200	COG0509	glycine decarboxylation via glycine cleavage system
JHE06_RS09205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JHE06_RS09220	COG1263	PTS System
JHE06_RS09220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS09225	COG1737	Transcriptional regulator
JHE06_RS09245	COG1737	Transcriptional regulator
JHE06_RS09250	COG0038	chloride channel
JHE06_RS09255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHE06_RS09260	COG0569	domain protein
JHE06_RS09265	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
JHE06_RS09270	COG2190	(PTS) system
JHE06_RS09270	COG1263	PTS System
JHE06_RS09270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS09275	COG4166	transmembrane transport
JHE06_RS09280	COG1272	protein, Hemolysin III
JHE06_RS09285	COG1393	Belongs to the ArsC family
JHE06_RS09290	COG2832	Protein of unknown function (DUF454)
JHE06_RS09300	COG0170	dolichyl monophosphate biosynthetic process
JHE06_RS09320	COG0346	lactoylglutathione lyase activity
JHE06_RS09325	COG0346	lactoylglutathione lyase activity
JHE06_RS09330	COG0667	Aldo Keto reductase
JHE06_RS09360	COG1309	transcriptional regulator
JHE06_RS09365	COG0577	efflux transmembrane transporter activity
JHE06_RS09370	COG1388	LysM domain
JHE06_RS09380	COG0765	amino acid transport
JHE06_RS09385	COG1126	abc transporter atp-binding protein
JHE06_RS09390	COG0436	Aminotransferase
JHE06_RS09410	COG5434	Belongs to the glycosyl hydrolase 28 family
JHE06_RS09420	COG2183	response to ionizing radiation
JHE06_RS09430	COG1174	glycine betaine transport
JHE06_RS09435	COG1125	glycine betaine transport
JHE06_RS09435	COG0517	IMP dehydrogenase activity
JHE06_RS09440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JHE06_RS09450	COG1136	(ABC) transporter
JHE06_RS09455	COG0577	efflux transmembrane transporter activity
JHE06_RS09460	COG1823	symporter activity
JHE06_RS09475	COG2252	PERMEase
JHE06_RS09490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHE06_RS09495	COG2860	membrane
JHE06_RS09505	COG2059	Chromate
JHE06_RS09510	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHE06_RS09515	COG1177	transmembrane transport
JHE06_RS09520	COG3842	ATPase activity
JHE06_RS09525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JHE06_RS09530	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JHE06_RS09535	COG0402	S-adenosylhomocysteine deaminase activity
JHE06_RS09540	COG1285	pathogenesis
JHE06_RS09555	COG1609	Transcriptional regulator
JHE06_RS09560	COG2017	converts alpha-aldose to the beta-anomer
JHE06_RS09565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHE06_RS09570	COG1554	hydrolase, family 65, central catalytic
JHE06_RS09575	COG1263	PTS System
JHE06_RS09575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS09575	COG2190	(PTS) system
JHE06_RS09590	COG2246	polysaccharide biosynthetic process
JHE06_RS09595	COG0463	Glycosyl transferase, family 2
JHE06_RS09600	COG0588	phosphoglycerate mutase activity
JHE06_RS09615	COG1263	PTS System
JHE06_RS09615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS09615	COG2190	(PTS) system
JHE06_RS09620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JHE06_RS09635	COG0105	UTP biosynthetic process
JHE06_RS09640	COG1028	Short-chain dehydrogenase reductase Sdr
JHE06_RS09655	COG0519	Catalyzes the synthesis of GMP from XMP
JHE06_RS09655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JHE06_RS09660	COG1072	(Pantothenic acid kinase))
JHE06_RS09675	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JHE06_RS09690	COG1304	FMN binding
JHE06_RS09700	COG1607	acyl-coa hydrolase
JHE06_RS09720	COG2116	formate transmembrane transporter activity
JHE06_RS09725	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JHE06_RS09730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JHE06_RS09745	COG1177	transmembrane transport
JHE06_RS09750	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHE06_RS09755	COG3842	ATPase activity
JHE06_RS09765	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JHE06_RS09770	COG0564	pseudouridine synthase activity
JHE06_RS09775	COG0569	domain protein
JHE06_RS09780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHE06_RS09790	COG0708	Exodeoxyribonuclease III
JHE06_RS09795	COG2188	Transcriptional regulator
JHE06_RS09800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS09805	COG2723	6-phospho-beta-galactosidase activity
JHE06_RS09810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JHE06_RS09815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS09820	COG1486	melibiose metabolic process
JHE06_RS09825	COG0583	DNA-binding transcription factor activity
JHE06_RS09835	COG1346	cytolysis
JHE06_RS09840	COG1304	FMN binding
JHE06_RS09850	COG2176	DNA-directed DNA polymerase activity
JHE06_RS09860	COG0802	atpase or kinase
JHE06_RS09865	COG2910	NAD(P)H-binding
JHE06_RS09870	COG0280	phosphate acetyltransferase
JHE06_RS09875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JHE06_RS09880	COG0561	phosphatase activity
JHE06_RS09890	COG2848	UPF0210 protein
JHE06_RS09895	COG3830	Belongs to the UPF0237 family
JHE06_RS09910	COG0765	amino acid transport
JHE06_RS09915	COG1126	abc transporter atp-binding protein
JHE06_RS09925	COG0475	glutathione-regulated potassium exporter activity
JHE06_RS09940	COG3584	3D domain protein
JHE06_RS09940	COG1388	LysM domain
JHE06_RS09960	COG0789	Transcriptional regulator
JHE06_RS09965	COG1114	Component of the transport system for branched-chain amino acids
JHE06_RS09970	COG1609	Transcriptional regulator
JHE06_RS09975	COG0765	amino acid transport
JHE06_RS09980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHE06_RS09985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHE06_RS10000	COG0488	(ABC) transporter
JHE06_RS10025	COG1621	beta-fructofuranosidase activity
JHE06_RS10035	COG1609	Transcriptional regulator
JHE06_RS10045	COG1132	(ABC) transporter
JHE06_RS10050	COG1132	(ABC) transporter
JHE06_RS10055	COG2207	Transcriptional regulator
JHE06_RS10055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHE06_RS10060	COG1442	glycosyl transferase family 8
JHE06_RS10065	COG1442	glycosyl transferase family 8
JHE06_RS10075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JHE06_RS10080	COG0824	Thioesterase
JHE06_RS10085	COG1252	NADH dehydrogenase
JHE06_RS10090	COG0142	geranyltranstransferase activity
JHE06_RS10095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JHE06_RS10100	COG4988	ABC transporter
JHE06_RS10105	COG1294	oxidase, subunit
JHE06_RS10110	COG1271	oxidase subunit
JHE06_RS10115	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JHE06_RS10120	COG1136	(ABC) transporter
JHE06_RS10130	COG1309	transcriptional regulator
JHE06_RS10135	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
JHE06_RS10140	COG0783	Belongs to the Dps family
JHE06_RS10160	COG4989	oxidoreductase activity
JHE06_RS10165	COG3425	synthase
JHE06_RS10170	COG0183	Belongs to the thiolase family
JHE06_RS10175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JHE06_RS10180	COG0628	permease
JHE06_RS10185	COG0432	Pfam Uncharacterised protein family UPF0047
JHE06_RS10195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JHE06_RS10200	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
JHE06_RS10240	COG3871	stress protein (general stress protein 26)
JHE06_RS10250	COG1028	Short-chain dehydrogenase reductase Sdr
JHE06_RS10255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JHE06_RS10260	COG1695	Transcriptional regulator
JHE06_RS10270	COG0346	lactoylglutathione lyase activity
JHE06_RS10275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHE06_RS10290	COG4166	transmembrane transport
JHE06_RS10295	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHE06_RS10305	COG1854	S-ribosylhomocysteine lyase activity
JHE06_RS10310	COG2226	methyltransferase
JHE06_RS10315	COG0626	cystathionine gamma-synthase activity
JHE06_RS10320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JHE06_RS10345	COG1442	glycosyl transferase family 8
JHE06_RS10355	COG4894	glucomannan catabolic process
JHE06_RS10375	COG0583	DNA-binding transcription factor activity
JHE06_RS10380	COG3426	butyrate kinase activity
JHE06_RS10385	COG0280	phosphate acetyltransferase
JHE06_RS10410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JHE06_RS10420	COG1028	Short-chain dehydrogenase reductase Sdr
JHE06_RS10445	COG0390	transport system, permease component
JHE06_RS10450	COG4619	ABC transporter
JHE06_RS10455	COG0574	Belongs to the PEP-utilizing enzyme family
JHE06_RS10455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHE06_RS10460	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JHE06_RS10465	COG0517	IMP dehydrogenase activity
JHE06_RS10485	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JHE06_RS10485	COG3291	Pkd domain containing protein
JHE06_RS10495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHE06_RS10510	COG3716	PTS system mannose fructose sorbose family IID component
JHE06_RS10515	COG3715	PTS system
JHE06_RS10520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS10525	COG2188	Transcriptional regulator
JHE06_RS10540	COG1131	(ABC) transporter
JHE06_RS10550	COG2160	L-arabinose isomerase activity
JHE06_RS10555	COG0235	Class ii aldolase
JHE06_RS10565	COG1609	Transcriptional regulator
JHE06_RS10575	COG4214	carbohydrate transport
JHE06_RS10585	COG4213	ABC transporter substrate-binding protein
JHE06_RS10590	COG2723	6-phospho-beta-galactosidase activity
JHE06_RS10605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHE06_RS10635	COG4172	Belongs to the ABC transporter superfamily
JHE06_RS10640	COG0601	transmembrane transport
JHE06_RS10645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHE06_RS10670	COG1464	Belongs to the NlpA lipoprotein family
JHE06_RS10680	COG1854	S-ribosylhomocysteine lyase activity
JHE06_RS10685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JHE06_RS10695	COG1464	Belongs to the NlpA lipoprotein family
JHE06_RS10700	COG0436	Aminotransferase
JHE06_RS10705	COG0371	Dehydrogenase
JHE06_RS10710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHE06_RS10715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JHE06_RS10720	COG1609	Transcriptional regulator
JHE06_RS10725	COG3775	system Galactitol-specific IIC component
JHE06_RS10730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JHE06_RS10735	COG0134	indole-3-glycerol-phosphate synthase activity
JHE06_RS10745	COG0133	tryptophan synthase activity
JHE06_RS10750	COG0159	tryptophan synthase activity
JHE06_RS10755	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JHE06_RS10765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS10780	COG3655	Transcriptional regulator
JHE06_RS10805	COG3684	Belongs to the aldolase LacD family
JHE06_RS10825	COG1349	DNA-binding transcription factor activity
JHE06_RS10830	COG1447	Phosphotransferase system cellobiose-specific component IIA
JHE06_RS10835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS10835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS10870	COG3012	SEC-C Motif Domain Protein
JHE06_RS10950	COG0346	lactoylglutathione lyase activity
JHE06_RS10955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHE06_RS10960	COG0431	NADPH-dependent FMN reductase
JHE06_RS10965	COG0655	NAD(P)H dehydrogenase (quinone) activity
JHE06_RS10970	COG2239	Acts as a magnesium transporter
JHE06_RS10990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHE06_RS10995	COG1940	carbohydrate kinase activity
JHE06_RS10995	COG1846	Transcriptional regulator
JHE06_RS11000	COG0656	L-ascorbic acid biosynthetic process
JHE06_RS11010	COG0789	Transcriptional regulator
JHE06_RS11035	COG1132	(ABC) transporter
JHE06_RS11040	COG1132	(ABC) transporter
JHE06_RS11050	COG2264	protein methyltransferase activity
JHE06_RS11060	COG1349	DNA-binding transcription factor activity
JHE06_RS11070	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JHE06_RS11075	COG0456	acetyltransferase
JHE06_RS11080	COG1846	Transcriptional regulator
JHE06_RS11090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHE06_RS11105	COG0431	NADPH-dependent FMN reductase
JHE06_RS11115	COG0435	Glutathione S-transferase
JHE06_RS11120	COG0673	inositol 2-dehydrogenase activity
JHE06_RS11125	COG0673	inositol 2-dehydrogenase activity
JHE06_RS11135	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JHE06_RS11145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHE06_RS11150	COG0702	epimerase
JHE06_RS11155	COG0656	L-ascorbic acid biosynthetic process
JHE06_RS11170	COG0110	maltose O-acetyltransferase activity
JHE06_RS11205	COG2217	Heavy metal translocating P-type atpase
JHE06_RS11210	COG3408	Glycogen debranching enzyme
JHE06_RS11210	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
JHE06_RS11215	COG3250	beta-galactosidase activity
JHE06_RS11220	COG0531	amino acid
JHE06_RS11235	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
JHE06_RS11240	COG0028	Belongs to the TPP enzyme family
JHE06_RS11250	COG2723	6-phospho-beta-galactosidase activity
JHE06_RS11255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS11255	COG1263	PTS System
JHE06_RS11255	COG2190	(PTS) system
JHE06_RS11260	COG1737	Transcriptional regulator
JHE06_RS11295	COG1063	alcohol dehydrogenase
JHE06_RS11310	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JHE06_RS11320	COG1733	regulation of RNA biosynthetic process
JHE06_RS11325	COG3791	Glutathione-dependent formaldehyde-activating
JHE06_RS11365	COG0662	Cupin 2, conserved barrel domain protein
JHE06_RS11390	COG1846	Transcriptional regulator
JHE06_RS11395	COG0778	Nitroreductase
JHE06_RS11425	COG2186	Transcriptional regulator
JHE06_RS11430	COG2814	Major facilitator Superfamily
JHE06_RS11435	COG2723	6-phospho-beta-galactosidase activity
JHE06_RS11440	COG1263	PTS System
JHE06_RS11440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS11440	COG2190	(PTS) system
JHE06_RS11445	COG1263	PTS System
JHE06_RS11445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS11460	COG2723	6-phospho-beta-galactosidase activity
JHE06_RS11485	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JHE06_RS11505	COG2390	Transcriptional regulator
JHE06_RS11505	COG4584	PFAM Integrase catalytic
JHE06_RS11510	COG1484	DNA-dependent DNA replication
JHE06_RS11555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JHE06_RS11570	COG0101	tRNA pseudouridine synthase activity
JHE06_RS11580	COG1122	ATPase activity
JHE06_RS11585	COG1122	ATPase activity
JHE06_RS11590	COG0203	ribosomal protein L17
JHE06_RS11595	COG0202	RNA polymerase activity
JHE06_RS11600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JHE06_RS11605	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JHE06_RS11610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JHE06_RS11615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JHE06_RS11620	COG0563	adenylate kinase activity
JHE06_RS11635	COG1841	ribosomal large subunit assembly
JHE06_RS11640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JHE06_RS11645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JHE06_RS11650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JHE06_RS11655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JHE06_RS11660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JHE06_RS11665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JHE06_RS11675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JHE06_RS11680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JHE06_RS11690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JHE06_RS11695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JHE06_RS11700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JHE06_RS11710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JHE06_RS11715	COG0089	rRNA binding
JHE06_RS11720	COG0088	Forms part of the polypeptide exit tunnel
JHE06_RS11725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JHE06_RS11730	COG0051	transcription antitermination factor activity, RNA binding
JHE06_RS11735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JHE06_RS11745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHE06_RS11750	COG0049	tRNA binding
JHE06_RS11755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JHE06_RS11765	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JHE06_RS11775	COG1012	belongs to the aldehyde dehydrogenase family
JHE06_RS11780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JHE06_RS11790	COG2813	Specifically methylates the guanine in position
JHE06_RS11795	COG0222	ribosome binding
JHE06_RS11800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JHE06_RS11805	COG0081	regulation of translation
JHE06_RS11810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JHE06_RS11825	COG0250	Participates in transcription elongation, termination and antitermination
JHE06_RS11835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JHE06_RS11845	COG1477	protein flavinylation
JHE06_RS11875	COG3688	RNA-binding protein containing a PIN domain
JHE06_RS11880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHE06_RS11885	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JHE06_RS11890	COG0215	cysteine-tRNA ligase activity
JHE06_RS11895	COG1045	serine acetyltransferase
JHE06_RS11900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHE06_RS11905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JHE06_RS11915	COG4956	integral membrane protein (PIN domain superfamily)
JHE06_RS11920	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JHE06_RS11925	COG0756	dUTP diphosphatase activity
JHE06_RS11930	COG3842	ATPase activity
JHE06_RS11935	COG0110	maltose O-acetyltransferase activity
JHE06_RS11940	COG1070	Carbohydrate kinase
JHE06_RS11970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHE06_RS11995	COG0517	IMP dehydrogenase activity
JHE06_RS11995	COG0516	GMP reductase activity
JHE06_RS12005	COG0012	GTP binding
JHE06_RS12010	COG4481	Protein conserved in bacteria
JHE06_RS12015	COG1475	DNA binding
JHE06_RS12020	COG1192	Involved in chromosome partitioning
JHE06_RS12025	COG0357	Ribosomal RNA small subunit methyltransferase G
JHE06_RS12040	COG0445	tRNA wobble uridine modification
JHE06_RS12045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JHE06_RS12050	COG1388	LysM domain
JHE06_RS12050	COG3584	3D domain protein
JHE06_RS12055	COG2188	Transcriptional regulator
JHE06_RS12060	COG0366	Alpha amylase catalytic
JHE06_RS12065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHE06_RS12065	COG1263	PTS System
JHE06_RS12070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JHE06_RS12075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JHE06_RS12085	COG1847	R3H domain protein
JHE06_RS12090	COG0706	membrane insertase activity
JHE06_RS12095	COG0594	ribonuclease P activity
JHE06_RS12100	COG0230	Belongs to the bacterial ribosomal protein bL34 family