locus-tag	class	description
FKL89_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FKL89_RS00010	COG0592	DNA-directed DNA polymerase activity
FKL89_RS00055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FKL89_RS00070	COG0387	Pfam Sodium calcium exchanger
FKL89_RS00090	COG0010	Belongs to the arginase family
FKL89_RS00125	COG2183	response to ionizing radiation
FKL89_RS00155	COG0445	tRNA wobble uridine modification
FKL89_RS00160	COG0357	Ribosomal RNA small subunit methyltransferase G
FKL89_RS00175	COG1192	Involved in chromosome partitioning
FKL89_RS00180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FKL89_RS00210	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FKL89_RS00215	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FKL89_RS00240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FKL89_RS00245	COG0121	glutamine amidotransferase
FKL89_RS00250	COG1393	Belongs to the ArsC family
FKL89_RS00260	COG3639	organic phosphonate transmembrane transporter activity
FKL89_RS00265	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FKL89_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FKL89_RS00300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FKL89_RS00325	COG1968	undecaprenyl-diphosphatase activity
FKL89_RS00340	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FKL89_RS00345	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FKL89_RS00355	COG0259	pyridoxamine-phosphate oxidase activity
FKL89_RS00360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FKL89_RS00380	COG0653	protein targeting
FKL89_RS00395	COG2326	polyphosphate kinase activity
FKL89_RS00410	COG2815	serine threonine protein kinase
FKL89_RS00410	COG0515	serine threonine protein kinase
FKL89_RS00415	COG5001	Diguanylate cyclase
FKL89_RS00450	COG0745	RESPONSE REGULATOR receiver
FKL89_RS00455	COG4251	negative regulation of phosphorylation
FKL89_RS00495	COG1187	pseudouridine synthase activity
FKL89_RS00525	COG0582	viral genome integration into host DNA
FKL89_RS00575	COG0629	single-stranded DNA binding
FKL89_RS00580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FKL89_RS00775	COG2003	Belongs to the UPF0758 family
FKL89_RS00830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FKL89_RS00870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FKL89_RS00935	COG3135	benzoate transporter
FKL89_RS00950	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FKL89_RS00955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FKL89_RS00960	COG0133	tryptophan synthase activity
FKL89_RS00965	COG0159	tryptophan synthase activity
FKL89_RS00970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FKL89_RS00975	COG0583	DNA-binding transcription factor activity
FKL89_RS01070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FKL89_RS01075	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FKL89_RS01090	COG3813	Protein conserved in bacteria
FKL89_RS01095	COG0067	glutamate synthase
FKL89_RS01095	COG0070	glutamate synthase
FKL89_RS01095	COG0069	glutamate synthase activity
FKL89_RS01200	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FKL89_RS01215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FKL89_RS01220	COG0698	ribose 5-phosphate isomerase
FKL89_RS01245	COG1673	EVE domain
FKL89_RS01255	COG0028	Belongs to the TPP enzyme family
FKL89_RS01270	COG0584	glycerophosphoryl diester phosphodiesterase
FKL89_RS01300	COG1175	transmembrane transport
FKL89_RS01305	COG0395	ABC-type sugar transport system, permease component
FKL89_RS01310	COG0861	Integral membrane protein TerC family
FKL89_RS01320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FKL89_RS01330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FKL89_RS01335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FKL89_RS01360	COG1132	(ABC) transporter
FKL89_RS01385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FKL89_RS01390	COG1116	anion transmembrane transporter activity
FKL89_RS01395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FKL89_RS01400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FKL89_RS01415	COG1216	Glycosyl transferase, family 2
FKL89_RS01420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FKL89_RS01430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FKL89_RS01445	COG4104	PAAR repeat-containing protein
FKL89_RS01455	COG0861	Integral membrane protein TerC family
FKL89_RS01460	COG0861	Integral membrane protein TerC family
FKL89_RS01470	COG1175	transmembrane transport
FKL89_RS01485	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FKL89_RS01490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FKL89_RS01500	COG0395	ABC-type sugar transport system, permease component
FKL89_RS01515	COG3842	ATPase activity
FKL89_RS01545	COG0676	glucose-6-phosphate 1-epimerase activity
FKL89_RS01550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FKL89_RS01565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FKL89_RS01575	COG0673	inositol 2-dehydrogenase activity
FKL89_RS01610	COG1522	sequence-specific DNA binding
FKL89_RS01635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FKL89_RS01640	COG0142	geranyltranstransferase activity
FKL89_RS01645	COG1722	exodeoxyribonuclease VII activity
FKL89_RS01660	COG2076	Multidrug Resistance protein
FKL89_RS01685	COG3046	protein related to deoxyribodipyrimidine photolyase
FKL89_RS01700	COG1469	GTP cyclohydrolase I activity
FKL89_RS01725	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FKL89_RS01770	COG0556	nucleotide-excision repair
FKL89_RS01810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FKL89_RS01815	COG1846	Transcriptional regulator
FKL89_RS01820	COG0179	Fumarylacetoacetate (FAA) hydrolase
FKL89_RS01830	COG1012	belongs to the aldehyde dehydrogenase family
FKL89_RS01840	COG3384	dioxygenase
FKL89_RS01850	COG3971	2-oxopent-4-enoate hydratase activity
FKL89_RS01860	COG0235	Class ii aldolase
FKL89_RS01875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FKL89_RS01910	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FKL89_RS01915	COG2937	Belongs to the GPAT DAPAT family
FKL89_RS01920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FKL89_RS01930	COG0066	3-isopropylmalate dehydratase activity
FKL89_RS01935	COG0473	3-isopropylmalate dehydrogenase activity
FKL89_RS01945	COG0101	tRNA pseudouridine synthase activity
FKL89_RS01950	COG0135	phosphoribosylanthranilate isomerase activity
FKL89_RS01955	COG0133	tryptophan synthase activity
FKL89_RS01960	COG0159	tryptophan synthase activity
FKL89_RS01975	COG0596	Alpha beta hydrolase
FKL89_RS01975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FKL89_RS01975	COG2226	methyltransferase
FKL89_RS01980	COG2267	carboxylic ester hydrolase activity
FKL89_RS02025	COG4456	Virulence-associated protein
FKL89_RS02030	COG1487	ribonuclease activity
FKL89_RS02040	COG3850	Histidine kinase
FKL89_RS02045	COG0745	RESPONSE REGULATOR receiver
FKL89_RS02085	COG0673	inositol 2-dehydrogenase activity
FKL89_RS02100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FKL89_RS02110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FKL89_RS02115	COG0006	proline dipeptidase activity
FKL89_RS02125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FKL89_RS02145	COG1024	Enoyl-CoA hydratase
FKL89_RS02145	COG1250	3-hydroxyacyl-CoA dehydrogenase
FKL89_RS02150	COG0456	acetyltransferase
FKL89_RS02245	COG0758	DNA mediated transformation
FKL89_RS02255	COG0242	peptide deformylase activity
FKL89_RS02260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FKL89_RS02270	COG2960	long-chain fatty acid transporting porin activity
FKL89_RS02285	COG0004	ammonium transporteR
FKL89_RS02310	COG0443	Heat shock 70 kDa protein
FKL89_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS02350	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FKL89_RS02350	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FKL89_RS02350	COG1703	isobutyryl-CoA mutase activity
FKL89_RS02355	COG0589	response to stress
FKL89_RS02360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FKL89_RS02365	COG4191	Histidine kinase
FKL89_RS02365	COG0784	Response regulator, receiver
FKL89_RS02390	COG3278	Belongs to the heme-copper respiratory oxidase family
FKL89_RS02405	COG2010	Cytochrome c
FKL89_RS02450	COG0181	hydroxymethylbilane synthase activity
FKL89_RS02460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FKL89_RS02465	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FKL89_RS02470	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FKL89_RS02480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FKL89_RS02520	COG0318	PFAM AMP-dependent synthetase and ligase
FKL89_RS02550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FKL89_RS02560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FKL89_RS02565	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FKL89_RS02570	COG0667	Aldo Keto reductase
FKL89_RS02575	COG2918	glutathione biosynthetic process
FKL89_RS02580	COG0427	acetyl-CoA hydrolase
FKL89_RS02600	COG0559	Belongs to the binding-protein-dependent transport system permease family
FKL89_RS02620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FKL89_RS02625	COG3706	GGDEF domain
FKL89_RS02630	COG4221	oxidoreductase activity
FKL89_RS02635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FKL89_RS02640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FKL89_RS02645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FKL89_RS02650	COG0741	lytic transglycosylase activity
FKL89_RS02655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FKL89_RS02670	COG0653	protein targeting
FKL89_RS02705	COG1040	competence protein
FKL89_RS02710	COG2267	carboxylic ester hydrolase activity
FKL89_RS02715	COG2226	methyltransferase
FKL89_RS02720	COG4953	penicillin-binding protein 1C
FKL89_RS02725	COG2373	Large extracellular alpha-helical protein
FKL89_RS02730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FKL89_RS02755	COG0284	orotidine-5'-phosphate decarboxylase activity
FKL89_RS02770	COG3150	esterase
FKL89_RS02775	COG0012	GTP binding
FKL89_RS02780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FKL89_RS02790	COG1560	Kdo2-lipid A biosynthetic process
FKL89_RS02795	COG0009	L-threonylcarbamoyladenylate synthase
FKL89_RS02800	COG1929	Belongs to the glycerate kinase type-1 family
FKL89_RS02805	COG0625	glutathione transferase activity
FKL89_RS02820	COG0754	glutathionylspermidine amidase activity
FKL89_RS02835	COG0318	PFAM AMP-dependent synthetase and ligase
FKL89_RS02840	COG1012	belongs to the aldehyde dehydrogenase family
FKL89_RS02855	COG1414	Transcriptional regulator
FKL89_RS02870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FKL89_RS02880	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FKL89_RS02905	COG0109	protoheme IX farnesyltransferase activity
FKL89_RS02910	COG1773	rubredoxin
FKL89_RS02915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FKL89_RS02920	COG1459	type II secretion system
FKL89_RS02965	COG1450	Type ii and iii secretion system protein
FKL89_RS03020	COG0126	phosphoglycerate kinase activity
FKL89_RS03030	COG1268	BioY protein
FKL89_RS03035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FKL89_RS03040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FKL89_RS03050	COG1538	Outer membrane efflux protein
FKL89_RS03060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKL89_RS03065	COG1309	transcriptional regulator
FKL89_RS03070	COG0646	methionine synthase
FKL89_RS03070	COG1410	methionine synthase
FKL89_RS03085	COG3181	Tripartite tricarboxylate transporter family receptor
FKL89_RS03090	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FKL89_RS03095	COG0508	dehydrogenase complex catalyzes the overall conversion of
FKL89_RS03100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FKL89_RS03120	COG2217	Heavy metal translocating P-type atpase
FKL89_RS03140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FKL89_RS03175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FKL89_RS03180	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FKL89_RS03190	COG5487	UPF0391 membrane protein
FKL89_RS03200	COG2823	Periplasmic or secreted lipoprotein
FKL89_RS03225	COG4585	Histidine kinase
FKL89_RS03230	COG2197	response regulator
FKL89_RS03235	COG2201	protein-glutamate methylesterase activity
FKL89_RS03300	COG1522	sequence-specific DNA binding
FKL89_RS03315	COG4166	transmembrane transport
FKL89_RS03325	COG0386	Belongs to the glutathione peroxidase family
FKL89_RS03330	COG0626	cystathionine gamma-synthase activity
FKL89_RS03335	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FKL89_RS03355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKL89_RS03360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FKL89_RS03390	COG3645	SOS response
FKL89_RS03395	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FKL89_RS03430	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FKL89_RS03440	COG1538	Outer membrane efflux protein
FKL89_RS03465	COG2211	Major facilitator Superfamily
FKL89_RS03485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FKL89_RS03495	COG0564	pseudouridine synthase activity
FKL89_RS03500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FKL89_RS03510	COG0268	Binds directly to 16S ribosomal RNA
FKL89_RS03515	COG0728	peptidoglycan biosynthetic process
FKL89_RS03525	COG0735	belongs to the Fur family
FKL89_RS03530	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FKL89_RS03535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FKL89_RS03550	COG0505	Belongs to the CarA family
FKL89_RS03560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FKL89_RS03565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FKL89_RS03585	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FKL89_RS03600	COG0709	Synthesizes selenophosphate from selenide and ATP
FKL89_RS03605	COG0604	alcohol dehydrogenase
FKL89_RS03630	COG1404	Belongs to the peptidase S8 family
FKL89_RS03640	COG2358	TRAP transporter, solute receptor (TAXI family
FKL89_RS03650	COG0004	ammonium transporteR
FKL89_RS03685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FKL89_RS03690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FKL89_RS03695	COG3178	'Phosphotransferase
FKL89_RS03700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FKL89_RS03705	COG0339	signal peptide processing
FKL89_RS03715	COG0708	Exodeoxyribonuclease III
FKL89_RS03720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FKL89_RS03725	COG3706	GGDEF domain
FKL89_RS03740	COG0583	DNA-binding transcription factor activity
FKL89_RS03745	COG1741	Belongs to the pirin family
FKL89_RS03755	COG2032	superoxide dismutase activity
FKL89_RS03760	COG3291	Pkd domain containing protein
FKL89_RS03765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FKL89_RS03765	COG2813	Specifically methylates the guanine in position
FKL89_RS03770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FKL89_RS03775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FKL89_RS03790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FKL89_RS03795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FKL89_RS03805	COG0189	ligase activity
FKL89_RS03815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FKL89_RS03820	COG0708	Exodeoxyribonuclease III
FKL89_RS03830	COG0488	(ABC) transporter
FKL89_RS03845	COG1250	3-hydroxyacyl-CoA dehydrogenase
FKL89_RS03850	COG0697	spore germination
FKL89_RS03855	COG0418	dihydroorotase activity
FKL89_RS03895	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FKL89_RS03900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FKL89_RS03905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FKL89_RS03910	COG4260	virion core protein, lumpy skin disease virus
FKL89_RS03945	COG0469	pyruvate kinase activity
FKL89_RS03960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FKL89_RS03980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FKL89_RS03985	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FKL89_RS03990	COG0511	ligase activity, forming carbon-carbon bonds
FKL89_RS03995	COG0439	Biotin carboxylase
FKL89_RS04000	COG2264	protein methyltransferase activity
FKL89_RS04025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FKL89_RS04030	COG0602	queuosine metabolic process
FKL89_RS04060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FKL89_RS04065	COG3039	Transposase
FKL89_RS04080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FKL89_RS04095	COG0235	Class ii aldolase
FKL89_RS04100	COG3181	Tripartite tricarboxylate transporter family receptor
FKL89_RS04120	COG1716	ATPase activity
FKL89_RS04125	COG0631	protein serine/threonine phosphatase activity
FKL89_RS04145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKL89_RS04160	COG0583	DNA-binding transcription factor activity
FKL89_RS04165	COG4336	lyase activity
FKL89_RS04215	COG0482	sulfurtransferase activity
FKL89_RS04225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FKL89_RS04230	COG0628	permease
FKL89_RS04240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FKL89_RS04250	COG0583	DNA-binding transcription factor activity
FKL89_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS04270	COG4948	Mandelate Racemase Muconate Lactonizing
FKL89_RS04280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FKL89_RS04280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FKL89_RS04290	COG2755	lipolytic protein G-D-S-L family
FKL89_RS04290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FKL89_RS04330	COG3279	Response regulator of the LytR AlgR family
FKL89_RS04335	COG3275	phosphorelay sensor kinase activity
FKL89_RS04360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FKL89_RS04365	COG1940	carbohydrate kinase activity
FKL89_RS04370	COG2188	Transcriptional regulator
FKL89_RS04375	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS04380	COG2721	sulfolactate sulfo-lyase activity
FKL89_RS04385	COG2721	sulfolactate sulfo-lyase activity
FKL89_RS04390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FKL89_RS04395	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FKL89_RS04410	COG2001	Belongs to the MraZ family
FKL89_RS04415	COG0275	rRNA processing
FKL89_RS04430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FKL89_RS04435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FKL89_RS04440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FKL89_RS04445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FKL89_RS04450	COG0772	Belongs to the SEDS family
FKL89_RS04455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FKL89_RS04460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FKL89_RS04465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FKL89_RS04480	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FKL89_RS04490	COG0739	heme binding
FKL89_RS04495	COG0653	protein targeting
FKL89_RS04500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FKL89_RS04510	COG0494	nUDIX hydrolase
FKL89_RS04515	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FKL89_RS04520	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FKL89_RS04525	COG0237	dephospho-CoA kinase activity
FKL89_RS04530	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FKL89_RS04545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FKL89_RS04550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FKL89_RS04620	COG0081	regulation of translation
FKL89_RS04625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FKL89_RS04630	COG0222	ribosome binding
FKL89_RS04635	COG0085	RNA polymerase activity
FKL89_RS04640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FKL89_RS04645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FKL89_RS04650	COG0049	tRNA binding
FKL89_RS04655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FKL89_RS04665	COG0051	transcription antitermination factor activity, RNA binding
FKL89_RS04670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FKL89_RS04675	COG0088	Forms part of the polypeptide exit tunnel
FKL89_RS04680	COG0089	rRNA binding
FKL89_RS04685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FKL89_RS04690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FKL89_RS04695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FKL89_RS04700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FKL89_RS04705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FKL89_RS04710	COG0255	Belongs to the universal ribosomal protein uL29 family
FKL89_RS04715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FKL89_RS04720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FKL89_RS04725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FKL89_RS04730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FKL89_RS04735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FKL89_RS04740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FKL89_RS04745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FKL89_RS04750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FKL89_RS04755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FKL89_RS04760	COG1841	ribosomal large subunit assembly
FKL89_RS04765	COG0200	Binds to the 23S rRNA
FKL89_RS04770	COG0201	protein transport
FKL89_RS04775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FKL89_RS04780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FKL89_RS04785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FKL89_RS04790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FKL89_RS04795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FKL89_RS04800	COG0202	RNA polymerase activity
FKL89_RS04805	COG0203	ribosomal protein L17
FKL89_RS04810	COG2261	transglycosylase associated protein
FKL89_RS04860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FKL89_RS04860	COG0674	pyruvate-flavodoxin oxidoreductase activity
FKL89_RS04875	COG1793	dna ligase
FKL89_RS04900	COG0516	GMP reductase activity
FKL89_RS04910	COG1840	ABC-type Fe3 transport system, periplasmic component
FKL89_RS04915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FKL89_RS04915	COG2010	Cytochrome c
FKL89_RS04925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FKL89_RS04940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FKL89_RS04945	COG4139	cobalamin transport
FKL89_RS04950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FKL89_RS04955	COG1802	Transcriptional regulator
FKL89_RS04970	COG0318	PFAM AMP-dependent synthetase and ligase
FKL89_RS04985	COG4269	membrane
FKL89_RS05035	COG0436	Aminotransferase
FKL89_RS05040	COG3647	Membrane
FKL89_RS05070	COG2972	Histidine kinase
FKL89_RS05095	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FKL89_RS05100	COG3265	gluconokinase activity
FKL89_RS05105	COG1534	Rna-binding protein
FKL89_RS05110	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FKL89_RS05115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FKL89_RS05140	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FKL89_RS05145	COG1562	ergosterol biosynthetic process
FKL89_RS05150	COG1562	ergosterol biosynthetic process
FKL89_RS05160	COG0544	peptidyl-prolyl cis-trans isomerase activity
FKL89_RS05165	COG0740	serine-type endopeptidase activity
FKL89_RS05170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FKL89_RS05175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FKL89_RS05195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FKL89_RS05210	COG0519	Catalyzes the synthesis of GMP from XMP
FKL89_RS05210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FKL89_RS05220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FKL89_RS05230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FKL89_RS05235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FKL89_RS05240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FKL89_RS05250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FKL89_RS05275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FKL89_RS05280	COG0477	Major facilitator Superfamily
FKL89_RS05285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FKL89_RS05330	COG1666	GTP binding
FKL89_RS05335	COG1136	(ABC) transporter
FKL89_RS05340	COG4591	ABC-type transport system involved in lipoprotein release permease component
FKL89_RS05370	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FKL89_RS05375	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FKL89_RS05400	COG1760	l-serine dehydratase
FKL89_RS05405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FKL89_RS05410	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FKL89_RS05420	COG0316	Belongs to the HesB IscA family
FKL89_RS05435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FKL89_RS05440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FKL89_RS05445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FKL89_RS05460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FKL89_RS05465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FKL89_RS05500	COG0629	single-stranded DNA binding
FKL89_RS05505	COG2814	Major facilitator Superfamily
FKL89_RS05520	COG0659	secondary active sulfate transmembrane transporter activity
FKL89_RS05530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FKL89_RS05530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FKL89_RS05535	COG0489	protein tyrosine kinase activity
FKL89_RS05540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FKL89_RS05555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FKL89_RS05565	COG0210	DNA helicase
FKL89_RS05575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FKL89_RS05575	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FKL89_RS05580	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FKL89_RS05595	COG1999	signal sequence binding
FKL89_RS05600	COG3384	dioxygenase
FKL89_RS05655	COG1222	aaa ATPase
FKL89_RS05660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FKL89_RS05670	COG0463	Glycosyl transferase, family 2
FKL89_RS05680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FKL89_RS05690	COG1215	transferase activity, transferring glycosyl groups
FKL89_RS05695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FKL89_RS05705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FKL89_RS05715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FKL89_RS05720	COG0741	lytic transglycosylase activity
FKL89_RS05725	COG0442	prolyl-tRNA aminoacylation
FKL89_RS05735	COG3047	cAMP biosynthetic process
FKL89_RS05745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FKL89_RS05750	COG1505	serine-type exopeptidase activity
FKL89_RS05760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FKL89_RS05765	COG1185	polyribonucleotide nucleotidyltransferase activity
FKL89_RS05800	COG1185	polyribonucleotide nucleotidyltransferase activity
FKL89_RS05815	COG1960	acyl-CoA dehydrogenase activity
FKL89_RS05835	COG0433	COG0433 Predicted ATPase
FKL89_RS05855	COG0596	Alpha beta hydrolase
FKL89_RS05895	COG1280	lysine exporter protein (LysE YggA)
FKL89_RS05900	COG3739	integral membrane protein
FKL89_RS05910	COG1131	(ABC) transporter
FKL89_RS05935	COG4681	YaeQ
FKL89_RS05960	COG0071	Belongs to the small heat shock protein (HSP20) family
FKL89_RS05970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FKL89_RS06140	COG1652	LysM domain
FKL89_RS06145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FKL89_RS06145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FKL89_RS06155	COG3214	Protein conserved in bacteria
FKL89_RS06160	COG0717	Belongs to the dCTP deaminase family
FKL89_RS06185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FKL89_RS06200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FKL89_RS06205	COG0625	glutathione transferase activity
FKL89_RS06215	COG2863	cytochrome
FKL89_RS06220	COG0446	pyridine nucleotide-disulphide oxidoreductase
FKL89_RS06225	COG2224	Isocitrate lyase
FKL89_RS06240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FKL89_RS06245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FKL89_RS06260	COG1546	Belongs to the CinA family
FKL89_RS06265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FKL89_RS06270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FKL89_RS06270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FKL89_RS06280	COG1960	acyl-CoA dehydrogenase activity
FKL89_RS06290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FKL89_RS06295	COG0140	phosphoribosyl-ATP diphosphatase activity
FKL89_RS06305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FKL89_RS06310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FKL89_RS06315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FKL89_RS06320	COG0805	protein transport
FKL89_RS06325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FKL89_RS06330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FKL89_RS06340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FKL89_RS06350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKL89_RS06355	COG4948	Mandelate Racemase Muconate Lactonizing
FKL89_RS06360	COG0318	PFAM AMP-dependent synthetase and ligase
FKL89_RS06365	COG0246	Mannitol dehydrogenase
FKL89_RS06375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FKL89_RS06385	COG0723	plastoquinol--plastocyanin reductase activity
FKL89_RS06390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FKL89_RS06395	COG2857	Cytochrome c1
FKL89_RS06400	COG0625	glutathione transferase activity
FKL89_RS06405	COG2969	positive regulation of protein catabolic process
FKL89_RS06415	COG0513	Belongs to the DEAD box helicase family
FKL89_RS06430	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS06450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FKL89_RS06460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FKL89_RS06465	COG0166	Belongs to the GPI family
FKL89_RS06475	COG0436	Aminotransferase
FKL89_RS06490	COG3842	ATPase activity
FKL89_RS06560	COG0028	Belongs to the TPP enzyme family
FKL89_RS06565	COG0440	acetolactate synthase activity
FKL89_RS06570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FKL89_RS06580	COG0604	alcohol dehydrogenase
FKL89_RS06580	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS06580	COG3321	synthase
FKL89_RS06585	COG0601	transmembrane transport
FKL89_RS06590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FKL89_RS06595	COG4172	Belongs to the ABC transporter superfamily
FKL89_RS06600	COG1280	lysine exporter protein (LysE YggA)
FKL89_RS06635	COG2814	Major facilitator Superfamily
FKL89_RS06650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FKL89_RS06655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FKL89_RS06655	COG1116	anion transmembrane transporter activity
FKL89_RS06660	COG1715	Restriction endonuclease
FKL89_RS06665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FKL89_RS06670	COG1280	lysine exporter protein (LysE YggA)
FKL89_RS06675	COG1131	(ABC) transporter
FKL89_RS06690	COG2308	Evidence 4 Homologs of previously reported genes of
FKL89_RS06700	COG1136	(ABC) transporter
FKL89_RS06715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FKL89_RS06740	COG1012	belongs to the aldehyde dehydrogenase family
FKL89_RS06755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FKL89_RS06765	COG3842	ATPase activity
FKL89_RS06770	COG1840	ABC-type Fe3 transport system, periplasmic component
FKL89_RS06775	COG1802	Transcriptional regulator
FKL89_RS06785	COG1012	belongs to the aldehyde dehydrogenase family
FKL89_RS06820	COG2059	Chromate
FKL89_RS06865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FKL89_RS06875	COG2308	Evidence 4 Homologs of previously reported genes of
FKL89_RS06910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FKL89_RS06920	COG0402	S-adenosylhomocysteine deaminase activity
FKL89_RS06930	COG4603	Belongs to the binding-protein-dependent transport system permease family
FKL89_RS06940	COG1744	ABC transporter substrate-binding protein PnrA-like
FKL89_RS06945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FKL89_RS06960	COG0473	3-isopropylmalate dehydrogenase activity
FKL89_RS06970	COG0596	Alpha beta hydrolase
FKL89_RS07005	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FKL89_RS07025	COG0826	peptidase U32
FKL89_RS07065	COG1181	Belongs to the D-alanine--D-alanine ligase family
FKL89_RS07075	COG2715	membrane protein required for spore maturation
FKL89_RS07085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FKL89_RS07090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FKL89_RS07100	COG1649	PFAM Uncharacterised BCR, COG1649
FKL89_RS07110	COG3023	N-Acetylmuramoyl-L-alanine amidase
FKL89_RS07120	COG1619	proteins homologs of microcin C7 resistance protein MccF
FKL89_RS07140	COG1864	DNA RNA non-specific endonuclease
FKL89_RS07140	COG3591	Belongs to the peptidase S1B family
FKL89_RS07150	COG0789	Transcriptional regulator
FKL89_RS07160	COG1049	propionate catabolic process, 2-methylcitrate cycle
FKL89_RS07175	COG2828	Protein conserved in bacteria
FKL89_RS07200	COG0039	L-malate dehydrogenase activity
FKL89_RS07205	COG2188	Transcriptional regulator
FKL89_RS07210	COG2009	succinate dehydrogenase
FKL89_RS07220	COG1053	succinate dehydrogenase
FKL89_RS07225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FKL89_RS07230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FKL89_RS07235	COG0372	Belongs to the citrate synthase family
FKL89_RS07240	COG0567	Dehydrogenase, E1 component
FKL89_RS07245	COG0508	dehydrogenase complex catalyzes the overall conversion of
FKL89_RS07250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FKL89_RS07255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FKL89_RS07280	COG0330	HflC and HflK could
FKL89_RS07285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FKL89_RS07290	COG1923	regulation of RNA biosynthetic process
FKL89_RS07295	COG1160	GTP binding
FKL89_RS07300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FKL89_RS07310	COG0124	histidyl-tRNA synthetase
FKL89_RS07320	COG3447	MASE1 domain protein
FKL89_RS07320	COG5002	protein histidine kinase activity
FKL89_RS07320	COG5001	Diguanylate cyclase
FKL89_RS07325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FKL89_RS07335	COG3063	Type IV pilus biogenesis stability protein PilW
FKL89_RS07340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FKL89_RS07345	COG0105	UTP biosynthetic process
FKL89_RS07400	COG3744	PilT protein domain protein
FKL89_RS07410	COG2824	Alkylphosphonate utilization operon protein PhnA
FKL89_RS07415	COG0823	Involved in the tonB-independent uptake of proteins
FKL89_RS07415	COG1506	peptidase
FKL89_RS07430	COG0303	'Molybdopterin
FKL89_RS07435	COG1597	lipid kinase activity
FKL89_RS07450	COG0746	molybdenum cofactor guanylyltransferase activity
FKL89_RS07455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FKL89_RS07465	COG0494	nUDIX hydrolase
FKL89_RS07485	COG0395	ABC-type sugar transport system, permease component
FKL89_RS07490	COG1175	transmembrane transport
FKL89_RS07495	COG1653	transport
FKL89_RS07500	COG3842	ATPase activity
FKL89_RS07525	COG1459	type II secretion system
FKL89_RS07540	COG0405	Gamma-glutamyltransferase
FKL89_RS07565	COG0154	amidase activity
FKL89_RS07570	COG0747	negative chemotaxis
FKL89_RS07575	COG0154	amidase activity
FKL89_RS07595	COG0009	L-threonylcarbamoyladenylate synthase
FKL89_RS07600	COG0583	DNA-binding transcription factor activity
FKL89_RS07605	COG2814	Major facilitator Superfamily
FKL89_RS07635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FKL89_RS07640	COG0481	GTPase activity
FKL89_RS07655	COG0571	ribonuclease III activity
FKL89_RS07660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FKL89_RS07665	COG1381	Involved in DNA repair and RecF pathway recombination
FKL89_RS07670	COG0736	holo-[acyl-carrier-protein] synthase activity
FKL89_RS07675	COG1472	Belongs to the glycosyl hydrolase 3 family
FKL89_RS07680	COG0322	excinuclease ABC activity
FKL89_RS07715	COG3181	Tripartite tricarboxylate transporter family receptor
FKL89_RS07725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FKL89_RS07735	COG1309	transcriptional regulator
FKL89_RS07740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FKL89_RS07745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FKL89_RS07755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKL89_RS07765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FKL89_RS07775	COG0446	pyridine nucleotide-disulphide oxidoreductase
FKL89_RS07800	COG0640	Transcriptional regulator
FKL89_RS07810	COG0745	RESPONSE REGULATOR receiver
FKL89_RS07815	COG2205	protein histidine kinase activity
FKL89_RS07820	COG4452	Inner membrane protein CreD
FKL89_RS07830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FKL89_RS07835	COG1414	Transcriptional regulator
FKL89_RS07870	COG0683	leucine binding
FKL89_RS07880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FKL89_RS07885	COG0183	Belongs to the thiolase family
FKL89_RS07895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FKL89_RS07915	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FKL89_RS07920	COG3657	addiction module killer protein
FKL89_RS07925	COG1794	racemase activity, acting on amino acids and derivatives
FKL89_RS07940	COG0280	phosphate acetyltransferase
FKL89_RS07940	COG0281	malic enzyme
FKL89_RS07950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FKL89_RS07955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FKL89_RS07980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FKL89_RS07995	COG1840	ABC-type Fe3 transport system, periplasmic component
FKL89_RS08000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FKL89_RS08015	COG2264	protein methyltransferase activity
FKL89_RS08020	COG0367	asparagine synthase
FKL89_RS08060	COG0484	heat shock protein binding
FKL89_RS08075	COG4464	protein tyrosine phosphatase activity
FKL89_RS08095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FKL89_RS08100	COG0367	asparagine synthase
FKL89_RS08125	COG1216	Glycosyl transferase, family 2
FKL89_RS08125	COG1442	glycosyl transferase family 8
FKL89_RS08130	COG0438	transferase activity, transferring glycosyl groups
FKL89_RS08140	COG0438	transferase activity, transferring glycosyl groups
FKL89_RS08145	COG0110	maltose O-acetyltransferase activity
FKL89_RS08155	COG0463	Glycosyl transferase, family 2
FKL89_RS08185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FKL89_RS08190	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FKL89_RS08195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FKL89_RS08200	COG0354	folic acid binding
FKL89_RS08205	COG0052	Belongs to the universal ribosomal protein uS2 family
FKL89_RS08210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FKL89_RS08215	COG0528	UMP kinase activity
FKL89_RS08220	COG0233	cytoplasmic translational termination
FKL89_RS08225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FKL89_RS08255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FKL89_RS08260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FKL89_RS08265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FKL89_RS08270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FKL89_RS08275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FKL89_RS08280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FKL89_RS08290	COG0667	Aldo Keto reductase
FKL89_RS08310	COG3181	Tripartite tricarboxylate transporter family receptor
FKL89_RS08315	COG3447	MASE1 domain protein
FKL89_RS08315	COG5002	protein histidine kinase activity
FKL89_RS08315	COG5001	Diguanylate cyclase
FKL89_RS08325	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FKL89_RS08330	COG1477	protein flavinylation
FKL89_RS08345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FKL89_RS08370	COG1570	exodeoxyribonuclease VII activity
FKL89_RS08380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FKL89_RS08390	COG0811	peptide transport
FKL89_RS08400	COG1663	tetraacyldisaccharide 4'-kinase activity
FKL89_RS08405	COG2835	tetraacyldisaccharide 4'-kinase activity
FKL89_RS08410	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FKL89_RS08430	COG0037	tRNA processing
FKL89_RS08435	COG0825	malonyl-CoA metabolic process
FKL89_RS08455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FKL89_RS08470	COG1595	DNA-templated transcription, initiation
FKL89_RS08505	COG2165	general secretion pathway protein
FKL89_RS08510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FKL89_RS08515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FKL89_RS08530	COG0084	hydrolase, TatD family'
FKL89_RS08540	COG0791	NLP P60 protein
FKL89_RS08545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FKL89_RS08550	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FKL89_RS08560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FKL89_RS08580	COG2850	peptidyl-arginine hydroxylation
FKL89_RS08590	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FKL89_RS08595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FKL89_RS08600	COG4942	peptidase
FKL89_RS08620	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FKL89_RS08625	COG1994	Peptidase M50
FKL89_RS08630	COG0180	Tryptophanyl-tRNA synthetase
FKL89_RS08640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FKL89_RS08645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FKL89_RS08660	COG0697	spore germination
FKL89_RS08670	COG0590	tRNA wobble adenosine to inosine editing
FKL89_RS08690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FKL89_RS08695	COG0726	polysaccharide deacetylase
FKL89_RS08700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FKL89_RS08700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FKL89_RS08705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FKL89_RS08705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FKL89_RS08715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FKL89_RS08720	COG2076	Multidrug Resistance protein
FKL89_RS08725	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FKL89_RS08735	COG1538	Outer membrane efflux protein
FKL89_RS08740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKL89_RS08755	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS08805	COG0642	Histidine kinase
FKL89_RS08810	COG0745	RESPONSE REGULATOR receiver
FKL89_RS08825	COG1858	cytochrome C peroxidase
FKL89_RS08830	COG0436	Aminotransferase
FKL89_RS08840	COG1404	Belongs to the peptidase S8 family
FKL89_RS08855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FKL89_RS08865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FKL89_RS08890	COG1846	Transcriptional regulator
FKL89_RS08915	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FKL89_RS08920	COG0424	maF-like protein
FKL89_RS08930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FKL89_RS08935	COG0416	fatty acid biosynthetic process
FKL89_RS08940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FKL89_RS09010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FKL89_RS09015	COG0527	aspartate kinase activity
FKL89_RS09025	COG1846	Transcriptional regulator
FKL89_RS09050	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FKL89_RS09065	COG0318	PFAM AMP-dependent synthetase and ligase
FKL89_RS09075	COG0725	ABC transporter, periplasmic molybdate-binding protein
FKL89_RS09080	COG4149	molybdate abc transporter
FKL89_RS09085	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FKL89_RS09090	COG0318	PFAM AMP-dependent synthetase and ligase
FKL89_RS09120	COG1175	transmembrane transport
FKL89_RS09125	COG0395	ABC-type sugar transport system, permease component
FKL89_RS09130	COG3842	ATPase activity
FKL89_RS09170	COG0589	response to stress
FKL89_RS09195	COG0656	L-ascorbic acid biosynthetic process
FKL89_RS09215	COG1943	Transposase
FKL89_RS09225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FKL89_RS09260	COG0154	amidase activity
FKL89_RS09265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FKL89_RS09270	COG1803	Methylglyoxal synthase
FKL89_RS09275	COG1024	Enoyl-CoA hydratase
FKL89_RS09280	COG0123	including yeast histone deacetylase and acetoin utilization protein
FKL89_RS09295	COG2826	transposase and inactivated derivatives, IS30 family
FKL89_RS09305	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS09315	COG1024	Enoyl-CoA hydratase
FKL89_RS09320	COG1960	acyl-CoA dehydrogenase activity
FKL89_RS09335	COG0347	Belongs to the P(II) protein family
FKL89_RS09340	COG1970	mechanosensitive ion channel activity
FKL89_RS09375	COG0312	modulator of DNA gyrase
FKL89_RS09395	COG0302	gtp cyclohydrolase
FKL89_RS09400	COG2233	PERMEase
FKL89_RS09405	COG2161	toxin-antitoxin pair type II binding
FKL89_RS09415	COG0556	nucleotide-excision repair
FKL89_RS09420	COG2095	MarC family integral membrane protein
FKL89_RS09435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKL89_RS09445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FKL89_RS09450	COG2186	Transcriptional regulator
FKL89_RS09465	COG4677	pectinesterase activity
FKL89_RS09470	COG1175	transmembrane transport
FKL89_RS09475	COG0395	ABC-type sugar transport system, permease component
FKL89_RS09480	COG3842	ATPase activity
FKL89_RS09490	COG0823	Involved in the tonB-independent uptake of proteins
FKL89_RS09495	COG3866	Pectate lyase
FKL89_RS09500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKL89_RS09505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FKL89_RS09510	COG1609	Transcriptional regulator
FKL89_RS09535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FKL89_RS09540	COG1012	belongs to the aldehyde dehydrogenase family
FKL89_RS09555	COG0156	8-amino-7-oxononanoate synthase activity
FKL89_RS09595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FKL89_RS09605	COG1752	Esterase of the alpha-beta hydrolase superfamily
FKL89_RS09645	COG1253	flavin adenine dinucleotide binding
FKL89_RS09650	COG0436	Aminotransferase
FKL89_RS09675	COG3128	pkhd-type hydroxylase
FKL89_RS09685	COG0625	glutathione transferase activity
FKL89_RS09720	COG0667	Aldo Keto reductase
FKL89_RS09725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FKL89_RS09730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FKL89_RS09735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FKL89_RS09745	COG0254	rRNA binding
FKL89_RS09750	COG0501	Belongs to the peptidase M48B family
FKL89_RS09770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FKL89_RS09780	COG2154	pterin-4-alpha-carbinolamine dehydratase
FKL89_RS09785	COG0501	Belongs to the peptidase M48B family
FKL89_RS09790	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FKL89_RS09795	COG2816	NAD+ diphosphatase activity
FKL89_RS09820	COG2914	Belongs to the UPF0125 (RnfH) family
FKL89_RS09825	COG2867	negative regulation of translational initiation
FKL89_RS09830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FKL89_RS09865	COG0583	DNA-binding transcription factor activity
FKL89_RS09875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FKL89_RS09890	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FKL89_RS09890	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FKL89_RS09895	COG0523	cobalamin synthesis protein
FKL89_RS09955	COG1250	3-hydroxyacyl-CoA dehydrogenase
FKL89_RS09960	COG1024	Enoyl-CoA hydratase
FKL89_RS09980	COG3396	Phenylacetate-CoA oxygenase
FKL89_RS09985	COG3460	Phenylacetate-CoA oxygenase
FKL89_RS09995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FKL89_RS10000	COG1309	transcriptional regulator
FKL89_RS10005	COG1024	Enoyl-CoA hydratase
FKL89_RS10010	COG1763	Mo-molybdopterin cofactor biosynthetic process
FKL89_RS10020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FKL89_RS10025	COG0314	molybdopterin synthase activity
FKL89_RS10035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FKL89_RS10035	COG1042	CoA-binding domain protein
FKL89_RS10035	COG0045	succinate-CoA ligase (ADP-forming) activity
FKL89_RS10050	COG0714	Associated with various cellular activities
FKL89_RS10060	COG1131	(ABC) transporter
FKL89_RS10070	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FKL89_RS10100	COG1012	belongs to the aldehyde dehydrogenase family
FKL89_RS10105	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FKL89_RS10110	COG1349	DNA-binding transcription factor activity
FKL89_RS10125	COG3842	ATPase activity
FKL89_RS10140	COG0494	nUDIX hydrolase
FKL89_RS10150	COG4290	ribonuclease
FKL89_RS10155	COG1832	CoA-binding protein
FKL89_RS10165	COG0601	transmembrane transport
FKL89_RS10170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FKL89_RS10175	COG0444	Belongs to the ABC transporter superfamily
FKL89_RS10180	COG4608	Belongs to the ABC transporter superfamily
FKL89_RS10185	COG0149	triose-phosphate isomerase activity
FKL89_RS10190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FKL89_RS10200	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FKL89_RS10205	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FKL89_RS10210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FKL89_RS10215	COG0649	NAD binding
FKL89_RS10220	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FKL89_RS10230	COG1034	ATP synthesis coupled electron transport
FKL89_RS10235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FKL89_RS10240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FKL89_RS10245	COG0839	Belongs to the complex I subunit 6 family
FKL89_RS10250	COG0713	ATP synthesis coupled electron transport
FKL89_RS10265	COG1007	ATP synthesis coupled electron transport
FKL89_RS10270	COG0583	DNA-binding transcription factor activity
FKL89_RS10275	COG1304	FMN binding
FKL89_RS10290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FKL89_RS10300	COG0739	heme binding
FKL89_RS10310	COG0492	ferredoxin-NADP+ reductase activity
FKL89_RS10330	COG0697	spore germination
FKL89_RS10355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FKL89_RS10360	COG0802	atpase or kinase
FKL89_RS10365	COG0860	N-Acetylmuramoyl-L-alanine amidase
FKL89_RS10370	COG0183	Belongs to the thiolase family
FKL89_RS10445	COG4644	lycopene metabolic process
FKL89_RS10460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FKL89_RS10465	COG1538	Outer membrane efflux protein
FKL89_RS10470	COG0842	Transport permease protein
FKL89_RS10475	COG0842	Transport permease protein
FKL89_RS10480	COG1131	(ABC) transporter
FKL89_RS10490	COG1309	transcriptional regulator
FKL89_RS10510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FKL89_RS10520	COG0776	regulation of translation
FKL89_RS10525	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FKL89_RS10575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FKL89_RS10580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FKL89_RS10585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FKL89_RS10595	COG0196	riboflavin kinase activity
FKL89_RS10600	COG1074	ATP-dependent DNA helicase activity
FKL89_RS10640	COG3501	Rhs element vgr protein
FKL89_RS10660	COG2815	serine threonine protein kinase
FKL89_RS10660	COG0515	serine threonine protein kinase
FKL89_RS10670	COG2226	methyltransferase
FKL89_RS10785	COG0613	PHP domain protein
FKL89_RS10790	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FKL89_RS10795	COG0642	Histidine kinase
FKL89_RS10810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FKL89_RS10815	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FKL89_RS10820	COG0148	phosphopyruvate hydratase activity
FKL89_RS10825	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FKL89_RS10830	COG0504	CTP synthase activity
FKL89_RS10855	COG1136	(ABC) transporter
FKL89_RS10860	COG1840	ABC-type Fe3 transport system, periplasmic component
FKL89_RS10870	COG2378	regulation of single-species biofilm formation
FKL89_RS10890	COG2130	NADP-dependent
FKL89_RS10895	COG0515	serine threonine protein kinase
FKL89_RS10895	COG2815	serine threonine protein kinase
FKL89_RS10905	COG2226	methyltransferase
FKL89_RS10910	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FKL89_RS10935	COG2197	response regulator
FKL89_RS10965	COG2703	oxygen carrier activity
FKL89_RS10970	COG2974	May be involved in recombination
FKL89_RS10985	COG2354	Protein conserved in bacteria
FKL89_RS10995	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FKL89_RS11000	COG0732	type I restriction modification DNA specificity domain
FKL89_RS11015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FKL89_RS11030	COG0776	regulation of translation
FKL89_RS11035	COG0072	phenylalanine-tRNA ligase activity
FKL89_RS11035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FKL89_RS11040	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FKL89_RS11045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FKL89_RS11050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FKL89_RS11055	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FKL89_RS11060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FKL89_RS11100	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FKL89_RS11105	COG3437	response regulator, receiver
FKL89_RS11105	COG0784	Response regulator, receiver
FKL89_RS11110	COG0494	nUDIX hydrolase
FKL89_RS11125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FKL89_RS11130	COG0287	Prephenate dehydrogenase
FKL89_RS11140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FKL89_RS11145	COG0859	PFAM glycosyl transferase family 9
FKL89_RS11175	COG4608	Belongs to the ABC transporter superfamily
FKL89_RS11180	COG0444	Belongs to the ABC transporter superfamily
FKL89_RS11190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FKL89_RS11195	COG1473	amidohydrolase
FKL89_RS11205	COG1473	amidohydrolase
FKL89_RS11240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FKL89_RS11255	COG0402	S-adenosylhomocysteine deaminase activity
FKL89_RS11260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FKL89_RS11280	COG2171	N-acyltransferase activity
FKL89_RS11285	COG0024	Methionine aminopeptidase
FKL89_RS11290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FKL89_RS11295	COG0242	peptide deformylase activity
FKL89_RS11300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FKL89_RS11310	COG2890	protein-(glutamine-N5) methyltransferase activity
FKL89_RS11330	COG2130	NADP-dependent
FKL89_RS11335	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS11345	COG1960	acyl-CoA dehydrogenase activity
FKL89_RS11355	COG0183	Belongs to the thiolase family
FKL89_RS11365	COG1250	3-hydroxyacyl-CoA dehydrogenase
FKL89_RS11365	COG1024	Enoyl-CoA hydratase
FKL89_RS11375	COG5001	Diguanylate cyclase
FKL89_RS11375	COG5002	protein histidine kinase activity
FKL89_RS11420	COG3706	GGDEF domain
FKL89_RS11430	COG0583	DNA-binding transcription factor activity
FKL89_RS11440	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS11495	COG3181	Tripartite tricarboxylate transporter family receptor
FKL89_RS11515	COG0305	Participates in initiation and elongation during chromosome replication
FKL89_RS11520	COG0543	2 iron, 2 sulfur cluster binding
FKL89_RS11520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FKL89_RS11525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FKL89_RS11535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FKL89_RS11550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FKL89_RS11560	COG1612	heme a metabolic process
FKL89_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS11595	COG2186	Transcriptional regulator
FKL89_RS11630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FKL89_RS11635	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FKL89_RS11640	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS11645	COG3243	poly(R)-hydroxyalkanoic acid synthase
FKL89_RS11685	COG1764	response to oxidative stress
FKL89_RS11690	COG1846	Transcriptional regulator
FKL89_RS11695	COG2917	probably involved in intracellular septation
FKL89_RS11705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FKL89_RS11730	COG1959	2 iron, 2 sulfur cluster binding
FKL89_RS11750	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FKL89_RS11770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FKL89_RS11780	COG1183	phosphatidylcholine synthase activity
FKL89_RS11785	COG1737	Transcriptional regulator
FKL89_RS11790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FKL89_RS11795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FKL89_RS11805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FKL89_RS11810	COG0123	including yeast histone deacetylase and acetoin utilization protein
FKL89_RS11820	COG0697	spore germination
FKL89_RS11845	COG0747	negative chemotaxis
FKL89_RS11860	COG0515	serine threonine protein kinase
FKL89_RS11860	COG2815	serine threonine protein kinase
FKL89_RS11865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FKL89_RS11875	COG0429	hydrolase of the alpha beta-hydrolase fold
FKL89_RS11880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FKL89_RS11900	COG1280	lysine exporter protein (LysE YggA)
FKL89_RS11905	COG1404	Belongs to the peptidase S8 family
FKL89_RS11915	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FKL89_RS11925	COG2721	sulfolactate sulfo-lyase activity
FKL89_RS11930	COG2814	Major facilitator Superfamily
FKL89_RS11940	COG0047	phosphoribosylformylglycinamidine synthase activity
FKL89_RS11940	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FKL89_RS11945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FKL89_RS11950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FKL89_RS11955	COG1053	succinate dehydrogenase
FKL89_RS11960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FKL89_RS11995	COG3275	phosphorelay sensor kinase activity
FKL89_RS12000	COG0306	phosphate transporter
FKL89_RS12035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FKL89_RS12040	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
FKL89_RS12075	COG0542	response to heat
FKL89_RS12090	COG0596	Alpha beta hydrolase
FKL89_RS12095	COG4555	ABC transporter
FKL89_RS12105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FKL89_RS12110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FKL89_RS12125	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FKL89_RS12130	COG2951	lytic endotransglycosylase activity
FKL89_RS12135	COG0167	dihydroorotate dehydrogenase activity
FKL89_RS12150	COG1643	Atp-dependent helicase
FKL89_RS12155	COG0747	negative chemotaxis
FKL89_RS12175	COG0446	pyridine nucleotide-disulphide oxidoreductase
FKL89_RS12175	COG1902	pentaerythritol trinitrate reductase activity
FKL89_RS12190	COG1595	DNA-templated transcription, initiation
FKL89_RS12210	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FKL89_RS12215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FKL89_RS12220	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FKL89_RS12230	COG0625	glutathione transferase activity
FKL89_RS12255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FKL89_RS12265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FKL89_RS12270	COG0714	Associated with various cellular activities
FKL89_RS12280	COG2304	oxidoreductase activity
FKL89_RS12315	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FKL89_RS12325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FKL89_RS12325	COG0473	3-isopropylmalate dehydrogenase activity
FKL89_RS12345	COG1522	sequence-specific DNA binding
FKL89_RS12350	COG2423	ornithine cyclodeaminase activity
FKL89_RS12365	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
FKL89_RS12370	COG0668	transmembrane transport
FKL89_RS12385	COG0557	exoribonuclease II activity
FKL89_RS12400	COG0560	Phosphoserine phosphatase
FKL89_RS12415	COG0616	signal peptide processing
FKL89_RS12430	COG1530	ribonuclease E activity
FKL89_RS12440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKL89_RS12445	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FKL89_RS12475	COG2132	Multicopper oxidase
FKL89_RS12500	COG0633	Ferredoxin
FKL89_RS12510	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FKL89_RS12520	COG0316	Belongs to the HesB IscA family
FKL89_RS12525	COG0822	iron-sulfur transferase activity
FKL89_RS12530	COG1104	cysteine desulfurase activity
FKL89_RS12545	COG1999	signal sequence binding
FKL89_RS12570	COG0625	glutathione transferase activity
FKL89_RS12585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FKL89_RS12620	COG3284	Transcriptional regulator
FKL89_RS12645	COG0300	oxidoreductase activity
FKL89_RS12650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FKL89_RS12660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FKL89_RS12660	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FKL89_RS12665	COG1309	transcriptional regulator
FKL89_RS12690	COG3608	succinylglutamate desuccinylase aspartoacylase
FKL89_RS12690	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FKL89_RS12695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FKL89_RS12700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FKL89_RS12710	COG1175	transmembrane transport
FKL89_RS12715	COG0395	ABC-type sugar transport system, permease component
FKL89_RS12730	COG1073	alpha beta
FKL89_RS12735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FKL89_RS12740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FKL89_RS12745	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FKL89_RS12750	COG2251	uridine kinase activity
FKL89_RS12750	COG0195	Participates in both transcription termination and antitermination
FKL89_RS12755	COG0779	Required for maturation of 30S ribosomal subunits
FKL89_RS12795	COG0318	PFAM AMP-dependent synthetase and ligase
FKL89_RS12805	COG0730	response to heat
FKL89_RS12815	COG0175	sulfate reduction
FKL89_RS12835	COG3383	formate dehydrogenase (NAD+) activity
FKL89_RS12860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FKL89_RS12880	COG2860	membrane
FKL89_RS12945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FKL89_RS12980	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FKL89_RS12995	COG4208	sulfate ABC transporter
FKL89_RS13000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FKL89_RS13005	COG0583	DNA-binding transcription factor activity
FKL89_RS13025	COG0277	FAD linked oxidase domain protein
FKL89_RS13025	COG0247	lactate metabolic process
FKL89_RS13035	COG0346	lactoylglutathione lyase activity
FKL89_RS13040	COG0339	signal peptide processing
FKL89_RS13045	COG2096	Adenosyltransferase
FKL89_RS13050	COG1024	Enoyl-CoA hydratase
FKL89_RS13080	COG1960	acyl-CoA dehydrogenase activity
FKL89_RS13085	COG0625	glutathione transferase activity
FKL89_RS13135	COG1914	H( )-stimulated, divalent metal cation uptake system
FKL89_RS13140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FKL89_RS13145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKL89_RS13150	COG1309	transcriptional regulator
FKL89_RS13155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FKL89_RS13160	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FKL89_RS13185	COG2972	Histidine kinase
FKL89_RS13200	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FKL89_RS13215	COG1428	Deoxynucleoside kinase
FKL89_RS13225	COG3040	lipid binding
FKL89_RS13250	COG4771	TonB-dependent receptor
FKL89_RS13275	COG4239	(ABC) transporter, permease
FKL89_RS13280	COG0601	transmembrane transport
FKL89_RS13285	COG4166	transmembrane transport
FKL89_RS13295	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FKL89_RS13295	COG0662	Cupin 2, conserved barrel domain protein
FKL89_RS13300	COG3118	belongs to the thioredoxin family
FKL89_RS13315	COG2259	Doxx family
FKL89_RS13320	COG2910	NAD(P)H-binding
FKL89_RS13325	COG0583	DNA-binding transcription factor activity
FKL89_RS13330	COG0563	adenylate kinase activity
FKL89_RS13335	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FKL89_RS13345	COG0477	Major facilitator Superfamily
FKL89_RS13350	COG0546	phosphoglycolate phosphatase activity
FKL89_RS13360	COG1126	abc transporter atp-binding protein
FKL89_RS13375	COG1910	domain protein
FKL89_RS13385	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS13400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FKL89_RS13405	COG3945	hemerythrin HHE cation binding domain
FKL89_RS13410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FKL89_RS13420	COG2070	2-Nitropropane dioxygenase
FKL89_RS13425	COG4771	TonB-dependent receptor
FKL89_RS13445	COG0288	reversible hydration of carbon dioxide
FKL89_RS13450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FKL89_RS13455	COG2181	nitrate reductase activity
FKL89_RS13460	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FKL89_RS13465	COG1140	nitrate reductase beta subunit
FKL89_RS13470	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FKL89_RS13485	COG2197	response regulator
FKL89_RS13490	COG3850	Histidine kinase
FKL89_RS13495	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FKL89_RS13500	COG0830	nickel cation binding
FKL89_RS13505	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FKL89_RS13510	COG0804	urea catabolic process
FKL89_RS13520	COG0831	urea catabolic process
FKL89_RS13525	COG0829	nickel cation binding
FKL89_RS13530	COG3135	benzoate transporter
FKL89_RS13540	COG1024	Enoyl-CoA hydratase
FKL89_RS13555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FKL89_RS13570	COG2186	Transcriptional regulator
FKL89_RS13590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKL89_RS13620	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FKL89_RS13625	COG1846	Transcriptional regulator
FKL89_RS13630	COG1215	transferase activity, transferring glycosyl groups
FKL89_RS13640	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FKL89_RS13645	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FKL89_RS13650	COG1187	pseudouridine synthase activity
FKL89_RS13655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FKL89_RS13665	COG0312	modulator of DNA gyrase
FKL89_RS13670	COG3028	Belongs to the UPF0307 family
FKL89_RS13675	COG0521	Mo-molybdopterin cofactor biosynthetic process
FKL89_RS13685	COG1612	heme a metabolic process
FKL89_RS13690	COG3706	GGDEF domain
FKL89_RS13695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FKL89_RS13700	COG0277	FAD linked oxidase domain protein
FKL89_RS13705	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS13710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FKL89_RS13720	COG3201	nicotinamide mononucleotide transporter
FKL89_RS13730	COG1238	metal cluster binding
FKL89_RS13765	COG0028	Belongs to the TPP enzyme family
FKL89_RS13775	COG2814	Major facilitator Superfamily
FKL89_RS13795	COG0247	lactate metabolic process
FKL89_RS13800	COG1592	Rubrerythrin
FKL89_RS13815	COG0513	Belongs to the DEAD box helicase family
FKL89_RS13850	COG1619	proteins homologs of microcin C7 resistance protein MccF
FKL89_RS13860	COG0525	valine-tRNA ligase activity
FKL89_RS13875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FKL89_RS13880	COG0795	lipopolysaccharide-transporting ATPase activity
FKL89_RS13885	COG0795	lipopolysaccharide-transporting ATPase activity
FKL89_RS13890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FKL89_RS13895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FKL89_RS13900	COG0142	geranyltranstransferase activity
FKL89_RS13920	COG0583	DNA-binding transcription factor activity
FKL89_RS13960	COG2159	amidohydrolase
FKL89_RS13970	COG0583	DNA-binding transcription factor activity
FKL89_RS13975	COG0583	DNA-binding transcription factor activity
FKL89_RS13980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKL89_RS14020	COG0513	Belongs to the DEAD box helicase family
FKL89_RS14060	COG2020	methyltransferase activity
FKL89_RS14065	COG2081	HI0933 family
FKL89_RS14145	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS14155	COG1063	alcohol dehydrogenase
FKL89_RS14175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FKL89_RS14175	COG2755	lipolytic protein G-D-S-L family
FKL89_RS14200	COG0411	ABC transporter
FKL89_RS14215	COG3706	GGDEF domain
FKL89_RS14225	COG0625	glutathione transferase activity
FKL89_RS14235	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FKL89_RS14270	COG1201	RNA secondary structure unwinding
FKL89_RS14280	COG0824	Thioesterase
FKL89_RS14285	COG0247	lactate metabolic process
FKL89_RS14290	COG0277	FAD linked oxidase domain protein
FKL89_RS14300	COG0277	FAD linked oxidase domain protein
FKL89_RS14305	COG0277	FAD linked oxidase domain protein
FKL89_RS14320	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS14330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FKL89_RS14340	COG0564	pseudouridine synthase activity
FKL89_RS14355	COG1199	ATP-dependent helicase activity
FKL89_RS14390	COG0587	DNA-directed DNA polymerase activity
FKL89_RS14395	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FKL89_RS14415	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FKL89_RS14420	COG0582	viral genome integration into host DNA
FKL89_RS14490	COG0437	4 iron, 4 sulfur cluster binding
FKL89_RS14495	COG0243	molybdopterin cofactor binding
FKL89_RS14495	COG3383	formate dehydrogenase (NAD+) activity
FKL89_RS14525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FKL89_RS14545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FKL89_RS14565	COG0492	ferredoxin-NADP+ reductase activity
FKL89_RS14570	COG1045	serine acetyltransferase
FKL89_RS14575	COG1473	amidohydrolase
FKL89_RS14605	COG0346	lactoylglutathione lyase activity
FKL89_RS14615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKL89_RS14645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FKL89_RS14655	COG1218	3'(2'),5'-bisphosphate nucleotidase
FKL89_RS14670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FKL89_RS14680	COG2271	Major facilitator Superfamily
FKL89_RS14685	COG2197	response regulator
FKL89_RS14690	COG2198	Histidine kinase
FKL89_RS14690	COG2205	protein histidine kinase activity
FKL89_RS14690	COG0784	Response regulator, receiver
FKL89_RS14695	COG3039	Transposase
FKL89_RS14705	COG0484	heat shock protein binding
FKL89_RS14710	COG0563	adenylate kinase activity
FKL89_RS14735	COG0243	molybdopterin cofactor binding
FKL89_RS14740	COG0437	4 iron, 4 sulfur cluster binding
FKL89_RS14760	COG5001	Diguanylate cyclase
FKL89_RS14760	COG3300	MHYT domain
FKL89_RS14780	COG0577	efflux transmembrane transporter activity
FKL89_RS14780	COG1136	(ABC) transporter
FKL89_RS14785	COG1136	(ABC) transporter
FKL89_RS14785	COG0577	efflux transmembrane transporter activity
FKL89_RS14805	COG1595	DNA-templated transcription, initiation
FKL89_RS14815	COG0251	oxidation-reduction process
FKL89_RS14820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FKL89_RS14825	COG1943	Transposase
FKL89_RS14830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FKL89_RS14845	COG0519	Catalyzes the synthesis of GMP from XMP
FKL89_RS14870	COG2137	regulation of response to DNA damage stimulus
FKL89_RS14875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FKL89_RS14955	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FKL89_RS14965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FKL89_RS15020	COG0612	Peptidase, M16
FKL89_RS15030	COG1346	cytolysis
FKL89_RS15050	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS15070	COG2119	membrane
FKL89_RS15085	COG1793	dna ligase
FKL89_RS15100	COG2203	Gaf domain
FKL89_RS15100	COG3706	GGDEF domain
FKL89_RS15100	COG4251	negative regulation of phosphorylation
FKL89_RS15100	COG5001	Diguanylate cyclase
FKL89_RS15115	COG5507	3-demethylubiquinone-9 3-methyltransferase
FKL89_RS15120	COG1309	transcriptional regulator
FKL89_RS15155	COG3258	Cytochrome c
FKL89_RS15170	COG1546	Belongs to the CinA family
FKL89_RS15170	COG1058	Belongs to the CinA family
FKL89_RS15195	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FKL89_RS15205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FKL89_RS15230	COG0724	RNA recognition motif
FKL89_RS15235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FKL89_RS15280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKL89_RS15285	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FKL89_RS15340	COG0789	Transcriptional regulator
FKL89_RS15360	COG3039	Transposase
FKL89_RS15380	COG0360	Binds together with S18 to 16S ribosomal RNA
FKL89_RS15385	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FKL89_RS15390	COG0359	binds to the 23S rRNA
FKL89_RS15400	COG2814	Major facilitator Superfamily
FKL89_RS15410	COG3088	subunit of a heme lyase
FKL89_RS15415	COG4235	cytochrome complex assembly
FKL89_RS15435	COG0174	glutamine synthetase
FKL89_RS15445	COG3852	Histidine kinase
FKL89_RS15485	COG2878	Part of a membrane complex involved in electron transport
FKL89_RS15490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FKL89_RS15515	COG0515	serine threonine protein kinase
FKL89_RS15515	COG2815	serine threonine protein kinase
FKL89_RS15525	COG1872	DUF167
FKL89_RS15555	COG2226	methyltransferase
FKL89_RS15610	COG4221	oxidoreductase activity
FKL89_RS15620	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FKL89_RS15625	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FKL89_RS15655	COG3245	cytochrome
FKL89_RS15660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FKL89_RS15695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FKL89_RS15750	COG3275	phosphorelay sensor kinase activity
FKL89_RS15755	COG0165	Argininosuccinate lyase
FKL89_RS15765	COG2084	Dehydrogenase
FKL89_RS15770	COG0542	response to heat
FKL89_RS15775	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FKL89_RS15780	COG1278	Cold shock
FKL89_RS15790	COG2885	chlorophyll binding
FKL89_RS15795	COG1752	Esterase of the alpha-beta hydrolase superfamily
FKL89_RS15800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FKL89_RS15810	COG1131	(ABC) transporter
FKL89_RS15825	COG3275	phosphorelay sensor kinase activity
FKL89_RS15835	COG0488	(ABC) transporter
FKL89_RS15855	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS15870	COG1902	pentaerythritol trinitrate reductase activity
FKL89_RS15880	COG0583	DNA-binding transcription factor activity
FKL89_RS15900	COG0107	imidazoleglycerol-phosphate synthase activity
FKL89_RS15910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FKL89_RS15915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FKL89_RS15920	COG0131	Imidazoleglycerol-phosphate dehydratase
FKL89_RS15925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FKL89_RS15930	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FKL89_RS15935	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FKL89_RS15940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FKL89_RS15945	COG0271	Belongs to the BolA IbaG family
FKL89_RS15950	COG0842	Transport permease protein
FKL89_RS15955	COG1131	(ABC) transporter
FKL89_RS15970	COG2853	Lipoprotein
FKL89_RS15980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FKL89_RS15985	COG1127	ABC transporter
FKL89_RS16000	COG0792	nuclease activity
FKL89_RS16005	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FKL89_RS16010	COG2823	Periplasmic or secreted lipoprotein
FKL89_RS16015	COG0425	Belongs to the sulfur carrier protein TusA family
FKL89_RS16025	COG0335	large ribosomal subunit rRNA binding
FKL89_RS16030	COG0336	Belongs to the RNA methyltransferase TrmD family
FKL89_RS16035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FKL89_RS16040	COG0228	four-way junction DNA binding
FKL89_RS16045	COG0243	molybdopterin cofactor binding
FKL89_RS16050	COG2146	nitrite reductase [NAD(P)H] activity
FKL89_RS16055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FKL89_RS16060	COG1116	anion transmembrane transporter activity
FKL89_RS16070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FKL89_RS16080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FKL89_RS16085	COG1214	PFAM Peptidase M22, glycoprotease
FKL89_RS16095	COG1573	uracil-dna glycosylase
FKL89_RS16100	COG1704	LemA family
FKL89_RS16120	COG3181	Tripartite tricarboxylate transporter family receptor
FKL89_RS16140	COG3220	belongs to the UPF0276 family
FKL89_RS16150	COG1595	DNA-templated transcription, initiation
FKL89_RS16155	COG4944	Protein of unknown function (DUF1109)
FKL89_RS16170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FKL89_RS16175	COG1943	Transposase
FKL89_RS16195	COG3181	Tripartite tricarboxylate transporter family receptor
FKL89_RS16205	COG2326	polyphosphate kinase activity
FKL89_RS16235	COG0402	S-adenosylhomocysteine deaminase activity
FKL89_RS16245	COG1228	amidohydrolase
FKL89_RS16260	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FKL89_RS16265	COG2986	histidine ammonia-lyase
FKL89_RS16275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FKL89_RS16285	COG3706	GGDEF domain
FKL89_RS16315	COG3501	Rhs element vgr protein
FKL89_RS16325	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FKL89_RS16340	COG0579	oxidoreductase
FKL89_RS16350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FKL89_RS16370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FKL89_RS16395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FKL89_RS16405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FKL89_RS16410	COG0326	Molecular chaperone. Has ATPase activity
FKL89_RS16420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FKL89_RS16430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FKL89_RS16435	COG1674	ftsk spoiiie
FKL89_RS16460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FKL89_RS16465	COG2815	serine threonine protein kinase
FKL89_RS16465	COG0515	serine threonine protein kinase
FKL89_RS16495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKL89_RS16515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FKL89_RS16530	COG2816	NAD+ diphosphatase activity
FKL89_RS16535	COG3063	Type IV pilus biogenesis stability protein PilW
FKL89_RS16555	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FKL89_RS16565	COG0753	catalase activity
FKL89_RS16570	COG0688	phosphatidylethanolamine metabolic process
FKL89_RS16600	COG1283	sodium-dependent phosphate transmembrane transporter activity
FKL89_RS16605	COG0586	Pfam SNARE associated Golgi protein
FKL89_RS16615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FKL89_RS16620	COG1862	Preprotein translocase
FKL89_RS16630	COG3181	Tripartite tricarboxylate transporter family receptor
FKL89_RS16635	COG0343	queuine tRNA-ribosyltransferase activity
FKL89_RS16640	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FKL89_RS16650	COG1024	Enoyl-CoA hydratase
FKL89_RS16685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FKL89_RS16690	COG1305	Transglutaminase-like
FKL89_RS16720	COG0737	Belongs to the 5'-nucleotidase family
FKL89_RS16755	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FKL89_RS16765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FKL89_RS16775	COG0495	leucyl-tRNA aminoacylation
FKL89_RS16790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FKL89_RS16795	COG2267	carboxylic ester hydrolase activity
FKL89_RS16820	COG2721	sulfolactate sulfo-lyase activity
FKL89_RS16825	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS16840	COG2239	Acts as a magnesium transporter
FKL89_RS16845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FKL89_RS16850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FKL89_RS16860	COG0557	exoribonuclease II activity
FKL89_RS16870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FKL89_RS16875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FKL89_RS16880	COG2833	Protein of unknown function (DUF455)
FKL89_RS16885	COG3181	Tripartite tricarboxylate transporter family receptor
FKL89_RS16895	COG0583	DNA-binding transcription factor activity
FKL89_RS16920	COG0824	Thioesterase
FKL89_RS16925	COG2255	four-way junction helicase activity
FKL89_RS16935	COG0632	four-way junction helicase activity
FKL89_RS16940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FKL89_RS16945	COG0393	Putative heavy-metal-binding
FKL89_RS16950	COG0217	transcriptional regulatory protein
FKL89_RS16960	COG1660	Displays ATPase and GTPase activities
FKL89_RS16965	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FKL89_RS16980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FKL89_RS16985	COG1137	ATPase activity
FKL89_RS16990	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FKL89_RS17000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FKL89_RS17010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FKL89_RS17015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FKL89_RS17030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FKL89_RS17035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FKL89_RS17065	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FKL89_RS17075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FKL89_RS17085	COG3181	Tripartite tricarboxylate transporter family receptor
FKL89_RS17095	COG3158	transport of potassium into the cell
FKL89_RS17100	COG0385	Bile acid
FKL89_RS17110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FKL89_RS17115	COG4597	amino acid ABC transporter
FKL89_RS17120	COG0765	amino acid transport
FKL89_RS17125	COG1126	abc transporter atp-binding protein
FKL89_RS17135	COG1454	alcohol dehydrogenase
FKL89_RS17140	COG2329	Antibiotic biosynthesis monooxygenase
FKL89_RS17160	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FKL89_RS17170	COG1022	Amp-dependent synthetase and ligase
FKL89_RS17215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FKL89_RS17220	COG0277	FAD linked oxidase domain protein
FKL89_RS17225	COG5001	Diguanylate cyclase
FKL89_RS17225	COG5002	protein histidine kinase activity
FKL89_RS17225	COG3447	MASE1 domain protein
FKL89_RS17230	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FKL89_RS17285	COG3483	tryptophan 2,3-dioxygenase activity
FKL89_RS17295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FKL89_RS17300	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FKL89_RS17315	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FKL89_RS17320	COG4133	protoheme IX ABC transporter activity
FKL89_RS17330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKL89_RS17335	COG1136	(ABC) transporter
FKL89_RS17350	COG1136	(ABC) transporter
FKL89_RS17350	COG0577	efflux transmembrane transporter activity
FKL89_RS17355	COG0612	Peptidase, M16
FKL89_RS17360	COG5265	(ABC) transporter
FKL89_RS17370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FKL89_RS17375	COG3568	Endonuclease Exonuclease Phosphatase
FKL89_RS17385	COG2133	pyrroloquinoline quinone binding
FKL89_RS17390	COG0724	RNA recognition motif
FKL89_RS17400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FKL89_RS17405	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FKL89_RS17410	COG4521	taurine ABC transporter
FKL89_RS17420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FKL89_RS17425	COG1519	Transferase
FKL89_RS17455	COG0633	Ferredoxin
FKL89_RS17455	COG3217	Mosc domain protein beta barrel domain protein
FKL89_RS17465	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FKL89_RS17470	COG0606	chelatase, subunit chli
FKL89_RS17490	COG1840	ABC-type Fe3 transport system, periplasmic component
FKL89_RS17495	COG1840	ABC-type Fe3 transport system, periplasmic component
FKL89_RS17505	COG1490	D-aminoacyl-tRNA deacylase activity
FKL89_RS17515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FKL89_RS17530	COG1960	acyl-CoA dehydrogenase activity
FKL89_RS17535	COG2003	Belongs to the UPF0758 family
FKL89_RS17540	COG0328	RNA-DNA hybrid ribonuclease activity
FKL89_RS17545	COG2226	methyltransferase
FKL89_RS17550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FKL89_RS17570	COG0019	diaminopimelate decarboxylase activity
FKL89_RS17580	COG1965	Belongs to the frataxin family
FKL89_RS17595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FKL89_RS17600	COG0751	glycine-tRNA ligase activity
FKL89_RS17605	COG0752	glycyl-tRNA synthetase alpha subunit
FKL89_RS17610	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FKL89_RS17615	COG4535	Mg2 and Co2 transporter CorC
FKL89_RS17620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FKL89_RS17625	COG1702	phosphate starvation-inducible protein PhoH
FKL89_RS17640	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FKL89_RS17650	COG0583	DNA-binding transcription factor activity
FKL89_RS17675	COG0584	glycerophosphoryl diester phosphodiesterase
FKL89_RS17690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FKL89_RS17695	COG0730	response to heat
FKL89_RS17725	COG4206	TonB-dependent receptor
FKL89_RS17730	COG1132	(ABC) transporter
FKL89_RS17740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FKL89_RS17745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FKL89_RS17755	COG0084	hydrolase, TatD family'
FKL89_RS17765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FKL89_RS17775	COG4770	biotin carboxylase activity
FKL89_RS17780	COG1024	Enoyl-CoA hydratase
FKL89_RS17785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FKL89_RS17800	COG1960	acyl-CoA dehydrogenase activity
FKL89_RS17805	COG0662	Cupin 2, conserved barrel domain protein
FKL89_RS17815	COG0183	Belongs to the thiolase family
FKL89_RS17825	COG0288	reversible hydration of carbon dioxide
FKL89_RS17830	COG1960	acyl-CoA dehydrogenase activity
FKL89_RS17840	COG0789	Transcriptional regulator
FKL89_RS17850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FKL89_RS17860	COG0243	molybdopterin cofactor binding
FKL89_RS17875	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FKL89_RS17880	COG3706	GGDEF domain
FKL89_RS17890	COG0459	protein refolding
FKL89_RS17895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FKL89_RS17910	COG1063	alcohol dehydrogenase
FKL89_RS17915	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS17920	COG1404	Belongs to the peptidase S8 family
FKL89_RS17920	COG4412	M6 family metalloprotease domain protein
FKL89_RS17960	COG1451	nucleotide metabolic process
FKL89_RS17985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FKL89_RS18010	COG1846	Transcriptional regulator
FKL89_RS18035	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FKL89_RS18045	COG2967	ApaG domain
FKL89_RS18050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FKL89_RS18060	COG0546	phosphoglycolate phosphatase activity
FKL89_RS18070	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FKL89_RS18075	COG0512	Glutamine amidotransferase of anthranilate synthase
FKL89_RS18080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FKL89_RS18085	COG0134	indole-3-glycerol-phosphate synthase activity
FKL89_RS18120	COG0583	DNA-binding transcription factor activity
FKL89_RS18140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FKL89_RS18155	COG0129	dihydroxy-acid dehydratase activity
FKL89_RS18210	COG0386	Belongs to the glutathione peroxidase family
FKL89_RS18215	COG3842	ATPase activity
FKL89_RS18230	COG0742	ribosomal rna small subunit methyltransferase
FKL89_RS18235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FKL89_RS18245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FKL89_RS18260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FKL89_RS18265	COG2391	methyltransferase activity
FKL89_RS18290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FKL89_RS18295	COG4181	ATPase activity
FKL89_RS18305	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FKL89_RS18310	COG2311	Membrane
FKL89_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS18330	COG0069	glutamate synthase activity
FKL89_RS18350	COG1280	lysine exporter protein (LysE YggA)
FKL89_RS18355	COG3300	MHYT domain
FKL89_RS18355	COG5001	Diguanylate cyclase
FKL89_RS18370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FKL89_RS18375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FKL89_RS18380	COG0546	phosphoglycolate phosphatase activity
FKL89_RS18395	COG1132	(ABC) transporter
FKL89_RS18400	COG2814	Major facilitator Superfamily
FKL89_RS18435	COG0515	serine threonine protein kinase
FKL89_RS18435	COG2815	serine threonine protein kinase
FKL89_RS18450	COG2815	serine threonine protein kinase
FKL89_RS18450	COG0515	serine threonine protein kinase
FKL89_RS18455	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FKL89_RS18470	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FKL89_RS18495	COG2205	protein histidine kinase activity
FKL89_RS18500	COG0745	RESPONSE REGULATOR receiver
FKL89_RS18510	COG0577	efflux transmembrane transporter activity
FKL89_RS18510	COG1136	(ABC) transporter
FKL89_RS18515	COG1136	(ABC) transporter
FKL89_RS18525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKL89_RS18540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FKL89_RS18550	COG4783	chaperone-mediated protein folding
FKL89_RS18555	COG0315	cyclic pyranopterin monophosphate synthase activity
FKL89_RS18575	COG1012	belongs to the aldehyde dehydrogenase family
FKL89_RS18580	COG2205	protein histidine kinase activity
FKL89_RS18590	COG2204	response regulator
FKL89_RS18595	COG0756	dUTP diphosphatase activity
FKL89_RS18600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FKL89_RS18605	COG0793	Belongs to the peptidase S41A family
FKL89_RS18615	COG1309	transcriptional regulator
FKL89_RS18635	COG0653	protein targeting
FKL89_RS18645	COG0321	lipoyl(octanoyl) transferase activity
FKL89_RS18650	COG2921	Belongs to the UPF0250 family
FKL89_RS18655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FKL89_RS18660	COG1686	Belongs to the peptidase S11 family
FKL89_RS18665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FKL89_RS18675	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FKL89_RS18685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FKL89_RS18715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FKL89_RS18720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FKL89_RS18725	COG3181	Tripartite tricarboxylate transporter family receptor
FKL89_RS18730	COG1686	Belongs to the peptidase S11 family
FKL89_RS18735	COG0497	DNA recombination
FKL89_RS18740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FKL89_RS18745	COG1420	regulation of RNA biosynthetic process
FKL89_RS18760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FKL89_RS18805	COG1943	Transposase
FKL89_RS18835	COG0300	oxidoreductase activity
FKL89_RS18845	COG1960	acyl-CoA dehydrogenase activity
FKL89_RS18850	COG1960	acyl-CoA dehydrogenase activity
FKL89_RS18860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FKL89_RS18870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FKL89_RS18885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FKL89_RS18890	COG0513	Belongs to the DEAD box helicase family
FKL89_RS18905	COG1595	DNA-templated transcription, initiation
FKL89_RS18915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FKL89_RS18915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FKL89_RS18925	COG0509	glycine decarboxylation via glycine cleavage system
FKL89_RS18930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FKL89_RS18935	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FKL89_RS18985	COG0706	membrane insertase activity
FKL89_RS18995	COG0594	ribonuclease P activity
FKL89_RS19000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FKL89_RS19030	COG0617	tRNA 3'-terminal CCA addition
FKL89_RS19045	COG0402	S-adenosylhomocysteine deaminase activity
FKL89_RS19090	COG3339	Conserved Protein
FKL89_RS19115	COG0408	coproporphyrinogen oxidase activity
FKL89_RS19120	COG0151	Belongs to the GarS family
FKL89_RS19125	COG0138	bifunctional purine biosynthesis protein purh
FKL89_RS19130	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FKL89_RS19145	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS19150	COG0415	Belongs to the DNA photolyase family
FKL89_RS19155	COG1678	Uncharacterized ACR, COG1678
FKL89_RS19160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FKL89_RS19165	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FKL89_RS19170	COG0540	Belongs to the ATCase OTCase family
FKL89_RS19180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FKL89_RS19195	COG3622	Belongs to the hyi family
FKL89_RS19200	COG2233	PERMEase
FKL89_RS19210	COG2351	hydroxyisourate hydrolase activity
FKL89_RS19225	COG0643	Histidine kinase
FKL89_RS19225	COG2198	Histidine kinase
FKL89_RS19230	COG0840	transmembrane signaling receptor activity
FKL89_RS19250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FKL89_RS19255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FKL89_RS19260	COG0631	protein serine/threonine phosphatase activity
FKL89_RS19265	COG1357	PFAM Pentapeptide repeats (8 copies)
FKL89_RS19265	COG0515	serine threonine protein kinase
FKL89_RS19270	COG1758	RNA polymerase activity
FKL89_RS19275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FKL89_RS19280	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FKL89_RS19345	COG0285	dihydrofolate synthase activity
FKL89_RS19350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FKL89_RS19360	COG1982	Orn Lys Arg decarboxylase major
FKL89_RS19370	COG2066	Belongs to the glutaminase family
FKL89_RS19375	COG0412	Dienelactone hydrolase
FKL89_RS19425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FKL89_RS19440	COG0308	aminopeptidase N
FKL89_RS19450	COG2176	DNA-directed DNA polymerase activity
FKL89_RS19465	COG2198	Histidine kinase
FKL89_RS19465	COG2205	protein histidine kinase activity
FKL89_RS19465	COG0784	Response regulator, receiver
FKL89_RS19525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FKL89_RS19545	COG0765	amino acid transport
FKL89_RS19550	COG0765	amino acid transport
FKL89_RS19555	COG1252	NADH dehydrogenase
FKL89_RS19565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FKL89_RS19580	COG1024	Enoyl-CoA hydratase
FKL89_RS19580	COG1250	3-hydroxyacyl-CoA dehydrogenase
FKL89_RS19585	COG0183	Belongs to the thiolase family
FKL89_RS19595	COG0588	phosphoglycerate mutase activity
FKL89_RS19630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FKL89_RS19635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FKL89_RS19640	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FKL89_RS19645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FKL89_RS19655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FKL89_RS19660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FKL89_RS19670	COG0356	it plays a direct role in the translocation of protons across the membrane
FKL89_RS19690	COG0483	inositol monophosphate 1-phosphatase activity
FKL89_RS19695	COG0678	peroxiredoxin activity
FKL89_RS19725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FKL89_RS19730	COG0154	amidase activity
FKL89_RS19735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FKL89_RS19740	COG1077	Cell shape determining protein MreB Mrl
FKL89_RS19755	COG0768	penicillin binding
FKL89_RS19760	COG0772	Belongs to the SEDS family
FKL89_RS19770	COG0823	Involved in the tonB-independent uptake of proteins
FKL89_RS19780	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FKL89_RS19785	COG1194	a g-specific adenine glycosylase
FKL89_RS19800	COG0515	serine threonine protein kinase
FKL89_RS19800	COG2815	serine threonine protein kinase
FKL89_RS19825	COG3186	Phenylalanine-4-hydroxylase
FKL89_RS19830	COG1272	protein, Hemolysin III
FKL89_RS19835	COG2116	formate transmembrane transporter activity
FKL89_RS19850	COG1028	Short-chain dehydrogenase reductase Sdr
FKL89_RS19855	COG0531	amino acid
FKL89_RS19860	COG2133	pyrroloquinoline quinone binding
FKL89_RS19885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FKL89_RS19890	COG0799	negative regulation of ribosome biogenesis
FKL89_RS19895	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FKL89_RS19900	COG0424	maF-like protein
FKL89_RS19905	COG1530	ribonuclease E activity
FKL89_RS19910	COG2863	cytochrome
FKL89_RS19945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FKL89_RS19960	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FKL89_RS19970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FKL89_RS19980	COG0683	leucine binding
FKL89_RS19990	COG0248	Ppx GppA phosphatase
FKL89_RS20005	COG3158	transport of potassium into the cell
FKL89_RS20010	COG0745	RESPONSE REGULATOR receiver
FKL89_RS20015	COG2205	protein histidine kinase activity
FKL89_RS20100	COG0581	inorganic phosphate transmembrane transporter activity
FKL89_RS20105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FKL89_RS20110	COG0704	Plays a role in the regulation of phosphate uptake
FKL89_RS20115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FKL89_RS20125	COG5000	phosphorelay sensor kinase activity
FKL89_RS20130	COG2204	response regulator