locus-tag	class	description
EXT02_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXT02_RS00010	COG0592	DNA-directed DNA polymerase activity
EXT02_RS00035	COG0285	dihydrofolate synthase activity
EXT02_RS00050	COG0360	Binds together with S18 to 16S ribosomal RNA
EXT02_RS00060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EXT02_RS00065	COG0359	binds to the 23S rRNA
EXT02_RS00065	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXT02_RS00070	COG0305	Participates in initiation and elongation during chromosome replication
EXT02_RS00075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXT02_RS00080	COG0009	L-threonylcarbamoyladenylate synthase
EXT02_RS00090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXT02_RS00095	COG0525	valine-tRNA ligase activity
EXT02_RS00100	COG4720	Psort location CytoplasmicMembrane, score
EXT02_RS00105	COG1122	ATPase activity
EXT02_RS00110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXT02_RS00145	COG0601	transmembrane transport
EXT02_RS00165	COG1131	(ABC) transporter
EXT02_RS00175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXT02_RS00180	COG0071	Belongs to the small heat shock protein (HSP20) family
EXT02_RS00185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXT02_RS00260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXT02_RS00265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXT02_RS00290	COG1970	mechanosensitive ion channel activity
EXT02_RS00335	COG0281	malic enzyme
EXT02_RS00340	COG3493	citrate carrier protein
EXT02_RS00400	COG1420	regulation of RNA biosynthetic process
EXT02_RS00405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EXT02_RS00410	COG0443	Heat shock 70 kDa protein
EXT02_RS00415	COG0484	heat shock protein binding
EXT02_RS00425	COG0552	protein localization to endoplasmic reticulum
EXT02_RS00430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXT02_RS00450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EXT02_RS00490	COG1461	Dihydroxyacetone kinase
EXT02_RS00515	COG1177	transmembrane transport
EXT02_RS00520	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXT02_RS00525	COG3839	Belongs to the ABC transporter superfamily
EXT02_RS00535	COG0765	amino acid transport
EXT02_RS00540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXT02_RS00545	COG1307	EDD domain protein, DegV family
EXT02_RS00575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXT02_RS00580	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXT02_RS00585	COG0537	adenosine 5'-monophosphoramidase activity
EXT02_RS00595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXT02_RS00600	COG0358	DNA primase activity
EXT02_RS00610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXT02_RS00615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXT02_RS00620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXT02_RS00670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EXT02_RS00675	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EXT02_RS00680	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EXT02_RS00685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EXT02_RS00695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXT02_RS00710	COG1183	phosphatidylcholine synthase activity
EXT02_RS00715	COG0688	phosphatidylethanolamine metabolic process
EXT02_RS00720	COG0504	CTP synthase activity
EXT02_RS00735	COG0571	ribonuclease III activity
EXT02_RS00740	COG0416	fatty acid biosynthetic process
EXT02_RS00750	COG0084	hydrolase, TatD family'
EXT02_RS00780	COG1136	(ABC) transporter
EXT02_RS00785	COG0072	phenylalanine-tRNA ligase activity
EXT02_RS00790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXT02_RS00825	COG0587	DNA-directed DNA polymerase activity
EXT02_RS00830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXT02_RS00835	COG0765	amino acid transport
EXT02_RS00845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXT02_RS00850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXT02_RS00855	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXT02_RS00860	COG1307	EDD domain protein, DegV family
EXT02_RS00875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXT02_RS00880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EXT02_RS00885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXT02_RS00890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXT02_RS00895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXT02_RS00920	COG1214	PFAM Peptidase M22, glycoprotease
EXT02_RS00930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXT02_RS00935	COG0187	DNA topoisomerase II activity
EXT02_RS01110	COG0765	amino acid transport
EXT02_RS01115	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EXT02_RS01120	COG1126	abc transporter atp-binding protein
EXT02_RS01125	COG0765	amino acid transport
EXT02_RS01215	COG1051	belongs to the nudix hydrolase family
EXT02_RS01220	COG0653	protein targeting
EXT02_RS01225	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EXT02_RS01230	COG0228	four-way junction DNA binding
EXT02_RS01235	COG0336	Belongs to the RNA methyltransferase TrmD family
EXT02_RS01240	COG0335	large ribosomal subunit rRNA binding
EXT02_RS01245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EXT02_RS01250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXT02_RS01255	COG0822	iron-sulfur transferase activity
EXT02_RS01260	COG0180	Tryptophanyl-tRNA synthetase
EXT02_RS01265	COG2176	DNA-directed DNA polymerase activity
EXT02_RS01275	COG0765	amino acid transport
EXT02_RS01280	COG0765	amino acid transport
EXT02_RS01285	COG0018	arginyl-trna synthetase
EXT02_RS01290	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXT02_RS01295	COG0513	Belongs to the DEAD box helicase family
EXT02_RS01325	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXT02_RS01330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EXT02_RS01340	COG0312	modulator of DNA gyrase
EXT02_RS01345	COG0481	GTPase activity
EXT02_RS01360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXT02_RS01365	COG0446	pyridine nucleotide-disulphide oxidoreductase
EXT02_RS01370	COG0736	holo-[acyl-carrier-protein] synthase activity
EXT02_RS01375	COG1481	regulation of sporulation
EXT02_RS01380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXT02_RS01385	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EXT02_RS01390	COG0778	Nitroreductase
EXT02_RS01395	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EXT02_RS01400	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EXT02_RS01405	COG0322	excinuclease ABC activity
EXT02_RS01410	COG0556	nucleotide-excision repair
EXT02_RS01415	COG0095	Lipoate-protein ligase
EXT02_RS01425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXT02_RS01430	COG2226	methyltransferase
EXT02_RS01435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXT02_RS01440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXT02_RS01445	COG4122	O-methyltransferase activity
EXT02_RS01450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXT02_RS01465	COG0742	ribosomal rna small subunit methyltransferase
EXT02_RS01470	COG3763	UPF0154 protein
EXT02_RS01495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EXT02_RS01505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXT02_RS01510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXT02_RS01515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXT02_RS01520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXT02_RS01535	COG0469	pyruvate kinase activity
EXT02_RS01545	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EXT02_RS01550	COG0148	phosphopyruvate hydratase activity
EXT02_RS01555	COG0166	Belongs to the GPI family
EXT02_RS01590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXT02_RS01595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXT02_RS01600	COG1692	metallophosphoesterase
EXT02_RS01605	COG1418	mRNA catabolic process
EXT02_RS01635	COG0445	tRNA wobble uridine modification
EXT02_RS01640	COG0357	Ribosomal RNA small subunit methyltransferase G
EXT02_RS01650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXT02_RS01655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXT02_RS01660	COG0049	tRNA binding
EXT02_RS01665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXT02_RS01670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXT02_RS01675	COG0085	RNA polymerase activity
EXT02_RS01680	COG0222	ribosome binding
EXT02_RS01685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXT02_RS01690	COG0081	regulation of translation
EXT02_RS01695	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXT02_RS01700	COG0250	Participates in transcription elongation, termination and antitermination
EXT02_RS01710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXT02_RS01715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXT02_RS01720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXT02_RS01725	COG1185	polyribonucleotide nucleotidyltransferase activity
EXT02_RS01765	COG0706	membrane insertase activity
EXT02_RS01770	COG0594	ribonuclease P activity
EXT02_RS01775	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXT02_RS01780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXT02_RS01795	COG0006	proline dipeptidase activity
EXT02_RS01800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXT02_RS01815	COG0776	regulation of translation
EXT02_RS01820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXT02_RS01825	COG1160	GTP binding
EXT02_RS01830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXT02_RS01835	COG1187	pseudouridine synthase activity
EXT02_RS01840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EXT02_RS01845	COG3118	belongs to the thioredoxin family
EXT02_RS01855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXT02_RS01865	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXT02_RS01870	COG0470	DNA polymerase III
EXT02_RS01875	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXT02_RS01880	COG0101	tRNA pseudouridine synthase activity
EXT02_RS01885	COG0203	ribosomal protein L17
EXT02_RS01890	COG0202	RNA polymerase activity
EXT02_RS01895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXT02_RS01900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXT02_RS01905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXT02_RS01910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EXT02_RS01915	COG0024	Methionine aminopeptidase
EXT02_RS01920	COG0563	adenylate kinase activity
EXT02_RS01925	COG0201	protein transport
EXT02_RS01930	COG0200	Binds to the 23S rRNA
EXT02_RS01935	COG1841	ribosomal large subunit assembly
EXT02_RS01940	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EXT02_RS01945	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXT02_RS01950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EXT02_RS01955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXT02_RS01960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EXT02_RS01965	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXT02_RS01970	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXT02_RS01975	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EXT02_RS01980	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXT02_RS01985	COG0255	Belongs to the universal ribosomal protein uL29 family
EXT02_RS01990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EXT02_RS02005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXT02_RS02010	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXT02_RS02015	COG0089	rRNA binding
EXT02_RS02020	COG0088	Forms part of the polypeptide exit tunnel
EXT02_RS02025	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXT02_RS02030	COG0051	transcription antitermination factor activity, RNA binding
EXT02_RS02040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXT02_RS02070	COG0210	DNA helicase
EXT02_RS02075	COG0210	DNA helicase
EXT02_RS02085	COG4608	Belongs to the ABC transporter superfamily
EXT02_RS02090	COG0444	Belongs to the ABC transporter superfamily
EXT02_RS02110	COG0601	transmembrane transport
EXT02_RS02115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXT02_RS02120	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXT02_RS02135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXT02_RS02140	COG0012	GTP binding
EXT02_RS02145	COG1162	GTPase activity
EXT02_RS02150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXT02_RS02155	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXT02_RS02160	COG1122	ATPase activity
EXT02_RS02165	COG1122	ATPase activity
EXT02_RS02190	COG0126	phosphoglycerate kinase activity
EXT02_RS02210	COG0149	triose-phosphate isomerase activity
EXT02_RS02215	COG4589	Belongs to the CDS family
EXT02_RS02220	COG0233	cytoplasmic translational termination
EXT02_RS02225	COG0528	UMP kinase activity
EXT02_RS02230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXT02_RS02235	COG0052	Belongs to the universal ribosomal protein uS2 family
EXT02_RS02240	COG0756	dUTP diphosphatase activity
EXT02_RS02295	COG1272	protein, Hemolysin III
EXT02_RS02330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXT02_RS02340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXT02_RS02345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXT02_RS02350	COG1253	flavin adenine dinucleotide binding
EXT02_RS02355	COG0193	aminoacyl-tRNA hydrolase activity
EXT02_RS02360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXT02_RS02365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXT02_RS02385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXT02_RS02395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXT02_RS02400	COG0301	tRNA thio-modification
EXT02_RS02410	COG0215	cysteine-tRNA ligase activity
EXT02_RS02415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXT02_RS02420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXT02_RS02425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXT02_RS02435	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EXT02_RS02440	COG3870	Protein conserved in bacteria
EXT02_RS02455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXT02_RS02460	COG0564	pseudouridine synthase activity
EXT02_RS02470	COG0037	tRNA processing
EXT02_RS02475	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXT02_RS02480	COG0124	histidyl-tRNA synthetase
EXT02_RS02485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXT02_RS02490	COG0482	sulfurtransferase activity
EXT02_RS02505	COG0459	protein refolding
EXT02_RS02510	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXT02_RS02530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXT02_RS02570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EXT02_RS02575	COG0254	rRNA binding
EXT02_RS02580	COG1435	thymidine kinase activity
EXT02_RS02585	COG0590	tRNA wobble adenosine to inosine editing
EXT02_RS02590	COG0617	tRNA 3'-terminal CCA addition
EXT02_RS02595	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXT02_RS02610	COG0577	efflux transmembrane transporter activity
EXT02_RS02610	COG1136	(ABC) transporter
EXT02_RS02620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXT02_RS02625	COG1321	iron dependent repressor
EXT02_RS02625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXT02_RS02630	COG1121	(ABC) transporter
EXT02_RS02635	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXT02_RS02650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXT02_RS02655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EXT02_RS02665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EXT02_RS02670	COG1054	Belongs to the UPF0176 family
EXT02_RS02680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EXT02_RS02690	COG0268	Binds directly to 16S ribosomal RNA
EXT02_RS02725	COG4869	propanediol catabolic process
EXT02_RS02730	COG1078	dGTPase activity
EXT02_RS02735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXT02_RS02740	COG2088	sporulation resulting in formation of a cellular spore
EXT02_RS02745	COG2217	Heavy metal translocating P-type atpase
EXT02_RS02755	COG0275	rRNA processing
EXT02_RS02760	COG1758	RNA polymerase activity
EXT02_RS02765	COG0194	GDP metabolic process
EXT02_RS02770	COG0495	leucyl-tRNA aminoacylation
EXT02_RS02775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXT02_RS02780	COG1363	Peptidase, m42
EXT02_RS02790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXT02_RS02795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EXT02_RS02800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EXT02_RS02805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXT02_RS02810	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXT02_RS02815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXT02_RS02835	COG1175	transmembrane transport
EXT02_RS02840	COG3842	ATPase activity
EXT02_RS02845	COG0017	Asparaginyl-tRNA synthetase