locus-tag	class	description
CCNA_00001	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CCNA_00002	COG0424	maF-like protein
CCNA_00004	COG0237	dephospho-CoA kinase activity
CCNA_00005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CCNA_00010	COG0443	Heat shock 70 kDa protein
CCNA_00011	COG0484	heat shock protein binding
CCNA_00012	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CCNA_00016	COG0314	molybdopterin synthase activity
CCNA_00018	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CCNA_00019	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CCNA_00024	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CCNA_00024	COG1648	precorrin-2 dehydrogenase activity
CCNA_00026	COG0784	Response regulator, receiver
CCNA_00026	COG2198	Histidine kinase
CCNA_00026	COG5002	protein histidine kinase activity
CCNA_00027	COG3128	pkhd-type hydroxylase
CCNA_00028	COG4774	siderophore transport
CCNA_00029	COG1280	lysine exporter protein (LysE YggA)
CCNA_00035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CCNA_00041	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CCNA_00045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CCNA_00048	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CCNA_00049	COG1396	sequence-specific DNA binding
CCNA_00050	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CCNA_00051	COG1253	flavin adenine dinucleotide binding
CCNA_00053	COG1702	phosphate starvation-inducible protein PhoH
CCNA_00054	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CCNA_00056	COG0456	acetyltransferase
CCNA_00060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CCNA_00062	COG0180	Tryptophanyl-tRNA synthetase
CCNA_00064	COG0840	transmembrane signaling receptor activity
CCNA_00068	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CCNA_00069	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CCNA_00074	COG1024	Enoyl-CoA hydratase
CCNA_00074	COG1250	3-hydroxyacyl-CoA dehydrogenase
CCNA_00075	COG0183	Belongs to the thiolase family
CCNA_00077	COG1960	acyl-CoA dehydrogenase activity
CCNA_00078	COG1960	acyl-CoA dehydrogenase activity
CCNA_00079	COG0789	Transcriptional regulator
CCNA_00083	COG0033	Phosphoglucomutase
CCNA_00084	COG0138	bifunctional purine biosynthesis protein purh
CCNA_00088	COG0433	COG0433 Predicted ATPase
CCNA_00089	COG5001	Diguanylate cyclase
CCNA_00089	COG3300	MHYT domain
CCNA_00091	COG0697	spore germination
CCNA_00100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CCNA_00101	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CCNA_00101	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CCNA_00105	COG2095	MarC family integral membrane protein
CCNA_00106	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCNA_00108	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CCNA_00115	COG1228	amidohydrolase
CCNA_00117	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CCNA_00125	COG1280	lysine exporter protein (LysE YggA)
CCNA_00132	COG0300	oxidoreductase activity
CCNA_00138	COG4772	TonB-dependent receptor
CCNA_00139	COG0606	chelatase, subunit chli
CCNA_00140	COG0189	ligase activity
CCNA_00143	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CCNA_00144	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CCNA_00145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CCNA_00146	COG0625	glutathione transferase activity
CCNA_00149	COG3655	Transcriptional regulator
CCNA_00150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCNA_00160	COG5278	phosphoserine phosphatase activity
CCNA_00160	COG0840	transmembrane signaling receptor activity
CCNA_00163	COG3206	protein involved in exopolysaccharide biosynthesis
CCNA_00163	COG0489	protein tyrosine kinase activity
CCNA_00165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CCNA_00175	COG2165	general secretion pathway protein
CCNA_00178	COG4795	General secretion pathway protein
CCNA_00183	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CCNA_00185	COG4771	TonB-dependent receptor
CCNA_00186	COG2252	PERMEase
CCNA_00188	COG1131	(ABC) transporter
CCNA_00190	COG1607	acyl-coa hydrolase
CCNA_00192	COG0318	PFAM AMP-dependent synthetase and ligase
CCNA_00193	COG0473	3-isopropylmalate dehydrogenase activity
CCNA_00194	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CCNA_00197	COG0335	large ribosomal subunit rRNA binding
CCNA_00198	COG0336	Belongs to the RNA methyltransferase TrmD family
CCNA_00205	COG2249	NAD(P)H dehydrogenase (quinone) activity
CCNA_00207	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CCNA_00209	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CCNA_00211	COG2957	Belongs to the agmatine deiminase family
CCNA_00217	COG4232	protein-disulfide reductase activity
CCNA_00223	COG2267	carboxylic ester hydrolase activity
CCNA_00227	COG0742	ribosomal rna small subunit methyltransferase
CCNA_00228	COG3548	integral membrane protein
CCNA_00230	COG1187	pseudouridine synthase activity
CCNA_00231	COG0590	tRNA wobble adenosine to inosine editing
CCNA_00233	COG1086	Polysaccharide biosynthesis protein
CCNA_00234	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CCNA_00237	COG0745	RESPONSE REGULATOR receiver
CCNA_00238	COG2205	protein histidine kinase activity
CCNA_00240	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCNA_00240	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCNA_00241	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCNA_00249	COG1999	signal sequence binding
CCNA_00252	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CCNA_00253	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CCNA_00255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CCNA_00257	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CCNA_00262	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CCNA_00264	COG1301	dicarboxylic acid transport
CCNA_00265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CCNA_00266	COG0183	Belongs to the thiolase family
CCNA_00267	COG2816	NAD+ diphosphatase activity
CCNA_00272	COG1322	Protein conserved in bacteria
CCNA_00283	COG2171	N-acyltransferase activity
CCNA_00286	COG0784	Response regulator, receiver
CCNA_00292	COG0573	inorganic phosphate transmembrane transporter activity
CCNA_00296	COG0745	RESPONSE REGULATOR receiver
CCNA_00299	COG0151	Belongs to the GarS family
CCNA_00302	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CCNA_00304	COG1519	Transferase
CCNA_00307	COG1132	(ABC) transporter
CCNA_00310	COG0483	inositol monophosphate 1-phosphatase activity
CCNA_00311	COG0312	modulator of DNA gyrase
CCNA_00315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CCNA_00321	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CCNA_00323	COG0523	cobalamin synthesis protein
CCNA_00324	COG0848	biopolymer transport protein
CCNA_00327	COG0778	Nitroreductase
CCNA_00339	COG2814	Major facilitator Superfamily
CCNA_00341	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CCNA_00342	COG0567	Dehydrogenase, E1 component
CCNA_00343	COG0508	dehydrogenase complex catalyzes the overall conversion of
CCNA_00346	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCNA_00348	COG0840	transmembrane signaling receptor activity
CCNA_00349	COG4974	Belongs to the 'phage' integrase family
CCNA_00352	COG1253	flavin adenine dinucleotide binding
CCNA_00353	COG2755	lipolytic protein G-D-S-L family
CCNA_00353	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CCNA_00356	COG3713	MltA-interacting MipA family protein
CCNA_00362	COG0735	belongs to the Fur family
CCNA_00363	COG0671	phosphoesterase, PA-phosphatase related
CCNA_00364	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CCNA_00366	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CCNA_00367	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CCNA_00368	COG3639	organic phosphonate transmembrane transporter activity
CCNA_00369	COG1253	flavin adenine dinucleotide binding
CCNA_00370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CCNA_00371	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CCNA_00372	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CCNA_00373	COG0356	it plays a direct role in the translocation of protons across the membrane
CCNA_00379	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CCNA_00381	COG1194	a g-specific adenine glycosylase
CCNA_00386	COG2818	Glycosylase
CCNA_00388	COG2267	carboxylic ester hydrolase activity
CCNA_00389	COG0354	folic acid binding
CCNA_00393	COG4941	Belongs to the sigma-70 factor family
CCNA_00394	COG3795	YCII-related domain
CCNA_00397	COG0028	Belongs to the TPP enzyme family
CCNA_00400	COG1846	Transcriptional regulator
CCNA_00401	COG1024	Enoyl-CoA hydratase
CCNA_00413	COG0617	tRNA 3'-terminal CCA addition
CCNA_00414	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CCNA_00414	COG0519	Catalyzes the synthesis of GMP from XMP
CCNA_00419	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CCNA_00432	COG1522	sequence-specific DNA binding
CCNA_00434	COG2855	membrane
CCNA_00435	COG0531	amino acid
CCNA_00436	COG1960	acyl-CoA dehydrogenase activity
CCNA_00437	COG0840	transmembrane signaling receptor activity
CCNA_00439	COG0840	transmembrane signaling receptor activity
CCNA_00441	COG0745	RESPONSE REGULATOR receiver
CCNA_00442	COG0643	Histidine kinase
CCNA_00442	COG2198	Histidine kinase
CCNA_00443	COG0835	chemotaxis
CCNA_00444	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CCNA_00445	COG2201	protein-glutamate methylesterase activity
CCNA_00446	COG0745	RESPONSE REGULATOR receiver
CCNA_00452	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CCNA_00453	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CCNA_00454	COG2188	Transcriptional regulator
CCNA_00456	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CCNA_00457	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCNA_00457	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCNA_00458	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCNA_00458	COG1263	PTS System
CCNA_00459	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CCNA_00464	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CCNA_00466	COG0438	transferase activity, transferring glycosyl groups
CCNA_00467	COG2244	polysaccharide biosynthetic process
CCNA_00471	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CCNA_00480	COG0582	viral genome integration into host DNA
CCNA_00481	COG1396	sequence-specific DNA binding
CCNA_00482	COG3550	peptidyl-serine autophosphorylation
CCNA_00483	COG3453	Protein conserved in bacteria
CCNA_00483	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CCNA_00485	COG0564	pseudouridine synthase activity
CCNA_00486	COG4771	TonB-dependent receptor
CCNA_00488	COG1280	lysine exporter protein (LysE YggA)
CCNA_00490	COG3739	integral membrane protein
CCNA_00491	COG0302	gtp cyclohydrolase
CCNA_00502	COG0463	Glycosyl transferase, family 2
CCNA_00504	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CCNA_00506	COG2857	Cytochrome c1
CCNA_00506	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CCNA_00507	COG2857	Cytochrome c1
CCNA_00507	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CCNA_00512	COG0012	GTP binding
CCNA_00514	COG1741	Belongs to the pirin family
CCNA_00515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CCNA_00523	COG1496	oxidoreductase activity
CCNA_00537	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CCNA_00538	COG0840	transmembrane signaling receptor activity
CCNA_00543	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CCNA_00545	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_00549	COG2801	Transposase and inactivated derivatives
CCNA_00550	COG1609	Transcriptional regulator
CCNA_00553	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CCNA_00555	COG0347	Belongs to the P(II) protein family
CCNA_00558	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CCNA_00562	COG0167	dihydroorotate dehydrogenase activity
CCNA_00564	COG5000	phosphorelay sensor kinase activity
CCNA_00565	COG0405	Gamma-glutamyltransferase
CCNA_00566	COG4948	Mandelate Racemase Muconate Lactonizing
CCNA_00567	COG3537	Alpha-1,2-mannosidase
CCNA_00568	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CCNA_00569	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CCNA_00570	COG2188	Transcriptional regulator
CCNA_00571	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCNA_00571	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCNA_00572	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCNA_00572	COG1263	PTS System
CCNA_00579	COG1864	DNA RNA non-specific endonuclease
CCNA_00579	COG3591	Belongs to the peptidase S1B family
CCNA_00601	COG0714	Associated with various cellular activities
CCNA_00609	COG1609	Transcriptional regulator
CCNA_00614	COG1288	antiporter activity
CCNA_00616	COG1522	sequence-specific DNA binding
CCNA_00618	COG1012	belongs to the aldehyde dehydrogenase family
CCNA_00619	COG3724	N-succinylarginine dihydrolase activity
CCNA_00620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CCNA_00623	COG2205	protein histidine kinase activity
CCNA_00625	COG0745	RESPONSE REGULATOR receiver
CCNA_00626	COG0840	transmembrane signaling receptor activity
CCNA_00628	COG0745	RESPONSE REGULATOR receiver
CCNA_00630	COG2198	Histidine kinase
CCNA_00630	COG0643	Histidine kinase
CCNA_00630	COG0784	Response regulator, receiver
CCNA_00632	COG0745	RESPONSE REGULATOR receiver
CCNA_00633	COG2201	protein-glutamate methylesterase activity
CCNA_00634	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CCNA_00645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CCNA_00646	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CCNA_00647	COG1116	anion transmembrane transporter activity
CCNA_00649	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CCNA_00650	COG2223	nitrite transmembrane transporter activity
CCNA_00651	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CCNA_00653	COG0243	molybdopterin cofactor binding
CCNA_00654	COG1648	precorrin-2 dehydrogenase activity
CCNA_00654	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CCNA_00656	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CCNA_00660	COG2801	Transposase and inactivated derivatives
CCNA_00660	COG3415	Transposase
CCNA_00665	COG3920	Histidine kinase
CCNA_00665	COG2202	Pas domain
CCNA_00674	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CCNA_00675	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
CCNA_00681	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_00683	COG3046	protein related to deoxyribodipyrimidine photolyase
CCNA_00685	COG1595	DNA-templated transcription, initiation
CCNA_00689	COG2205	protein histidine kinase activity
CCNA_00689	COG2198	Histidine kinase
CCNA_00689	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCNA_00689	COG0784	Response regulator, receiver
CCNA_00691	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CCNA_00695	COG1228	amidohydrolase
CCNA_00701	COG1278	Cold shock
CCNA_00736	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CCNA_00737	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CCNA_00738	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCNA_00740	COG0196	riboflavin kinase activity
CCNA_00741	COG2030	dehydratase
CCNA_00746	COG2169	Transcriptional regulator
CCNA_00746	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CCNA_00747	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CCNA_00751	COG2311	Membrane
CCNA_00752	COG1250	3-hydroxyacyl-CoA dehydrogenase
CCNA_00753	COG1509	lysine 2,3-aminomutase activity
CCNA_00764	COG2086	electron transfer activity
CCNA_00769	COG1309	transcriptional regulator
CCNA_00770	COG1309	transcriptional regulator
CCNA_00773	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CCNA_00775	COG0436	Aminotransferase
CCNA_00777	COG3300	MHYT domain
CCNA_00777	COG5001	Diguanylate cyclase
CCNA_00778	COG1217	gtp-binding protein TYPA
CCNA_00782	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CCNA_00785	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CCNA_00785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CCNA_00789	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CCNA_00792	COG0438	transferase activity, transferring glycosyl groups
CCNA_00793	COG0438	transferase activity, transferring glycosyl groups
CCNA_00796	COG4191	Histidine kinase
CCNA_00798	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CCNA_00799	COG4988	ABC transporter
CCNA_00801	COG1294	oxidase, subunit
CCNA_00803	COG0835	chemotaxis
CCNA_00809	COG3321	synthase
CCNA_00809	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_00809	COG0604	alcohol dehydrogenase
CCNA_00810	COG0657	acetylesterase activity
CCNA_00813	COG0492	ferredoxin-NADP+ reductase activity
CCNA_00820	COG0183	Belongs to the thiolase family
CCNA_00824	COG2186	Transcriptional regulator
CCNA_00825	COG0800	Aldolase
CCNA_00826	COG3734	2-keto-3-deoxy-galactonokinase
CCNA_00830	COG1874	Beta-galactosidase
CCNA_00831	COG1501	Belongs to the glycosyl hydrolase 31 family
CCNA_00834	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCNA_00835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCNA_00836	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCNA_00838	COG4948	Mandelate Racemase Muconate Lactonizing
CCNA_00839	COG1472	Belongs to the glycosyl hydrolase 3 family
CCNA_00844	COG3668	Plasmid stabilization system
CCNA_00850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCNA_00853	COG1611	Belongs to the LOG family
CCNA_00854	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CCNA_00855	COG2755	lipolytic protein G-D-S-L family
CCNA_00856	COG3507	Belongs to the glycosyl hydrolase 43 family
CCNA_00857	COG0477	Major facilitator Superfamily
CCNA_00862	COG0129	dihydroxy-acid dehydratase activity
CCNA_00869	COG1002	Type II restriction enzyme, methylase subunits
CCNA_00871	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CCNA_00872	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CCNA_00878	COG0513	Belongs to the DEAD box helicase family
CCNA_00879	COG2202	Pas domain
CCNA_00879	COG3920	Histidine kinase
CCNA_00886	COG0527	aspartate kinase activity
CCNA_00891	COG0697	spore germination
CCNA_00894	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CCNA_00898	COG1187	pseudouridine synthase activity
CCNA_00899	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CCNA_00900	COG5001	Diguanylate cyclase
CCNA_00900	COG3300	MHYT domain
CCNA_00902	COG1879	ABC-type sugar transport system periplasmic component
CCNA_00903	COG1129	ABC transporter
CCNA_00904	COG1172	Belongs to the binding-protein-dependent transport system permease family
CCNA_00908	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CCNA_00916	COG3668	Plasmid stabilization system
CCNA_00917	COG3609	addiction module antidote protein, CC2985 family
CCNA_00918	COG2890	protein-(glutamine-N5) methyltransferase activity
CCNA_00922	COG0542	response to heat
CCNA_00930	COG0307	riboflavin synthase, alpha
CCNA_00931	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CCNA_00931	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CCNA_00932	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CCNA_00940	COG5001	Diguanylate cyclase
CCNA_00940	COG3300	MHYT domain
CCNA_00941	COG0482	sulfurtransferase activity
CCNA_00947	COG1749	Flagellar hook protein flgE
CCNA_00950	COG1766	The M ring may be actively involved in energy transduction
CCNA_00951	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCNA_00952	COG1317	bacterial-type flagellum organization
CCNA_00953	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCNA_00954	COG2204	response regulator
CCNA_00956	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CCNA_00957	COG3746	phosphate-selective porin O and P
CCNA_00962	COG1846	Transcriptional regulator
CCNA_00963	COG1764	response to oxidative stress
CCNA_00965	COG0484	heat shock protein binding
CCNA_00970	COG0318	PFAM AMP-dependent synthetase and ligase
CCNA_00971	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CCNA_00976	COG0616	signal peptide processing
CCNA_00977	COG3293	Transposase
CCNA_00981	COG1136	(ABC) transporter
CCNA_00982	COG4957	zinc ion binding
CCNA_00983	COG2205	protein histidine kinase activity
CCNA_00983	COG2198	Histidine kinase
CCNA_00983	COG0784	Response regulator, receiver
CCNA_00987	COG3237	CsbD-like
CCNA_00996	COG1024	Enoyl-CoA hydratase
CCNA_00998	COG4957	zinc ion binding
CCNA_01001	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCNA_01002	COG1338	Plays a role in the flagellum-specific transport system
CCNA_01003	COG3190	flagellar
CCNA_01005	COG1558	bacterial-type flagellum-dependent cell motility
CCNA_01006	COG1677	Flagellar hook-basal body complex protein FliE
CCNA_01014	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CCNA_01015	COG2132	Multicopper oxidase
CCNA_01016	COG3667	copper resistance
CCNA_01019	COG1472	Belongs to the glycosyl hydrolase 3 family
CCNA_01020	COG1609	Transcriptional regulator
CCNA_01028	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CCNA_01029	COG3250	beta-galactosidase activity
CCNA_01030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CCNA_01034	COG4206	TonB-dependent receptor
CCNA_01035	COG0405	Gamma-glutamyltransferase
CCNA_01037	COG2186	Transcriptional regulator
CCNA_01039	COG2271	Major facilitator Superfamily
CCNA_01040	COG3507	Belongs to the glycosyl hydrolase 43 family
CCNA_01042	COG4771	TonB-dependent receptor
CCNA_01046	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CCNA_01050	COG0488	(ABC) transporter
CCNA_01056	COG0275	rRNA processing
CCNA_01059	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CCNA_01061	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCNA_01064	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CCNA_01069	COG0500	methyltransferase
CCNA_01071	COG0477	Major facilitator Superfamily
CCNA_01078	COG2226	methyltransferase
CCNA_01083	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CCNA_01088	COG2862	Uncharacterized protein family, UPF0114
CCNA_01091	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CCNA_01095	COG0072	phenylalanine-tRNA ligase activity
CCNA_01095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CCNA_01106	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CCNA_01110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCNA_01114	COG2166	iron-sulfur cluster assembly
CCNA_01116	COG2205	protein histidine kinase activity
CCNA_01123	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CCNA_01124	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CCNA_01129	COG1987	bacterial-type flagellum assembly
CCNA_01130	COG1684	flagellar biosynthetic protein fliR
CCNA_01131	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CCNA_01140	COG5001	Diguanylate cyclase
CCNA_01140	COG5002	protein histidine kinase activity
CCNA_01149	COG4206	TonB-dependent receptor
CCNA_01152	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CCNA_01157	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CCNA_01157	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CCNA_01161	COG1823	symporter activity
CCNA_01166	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CCNA_01167	COG1960	acyl-CoA dehydrogenase activity
CCNA_01168	COG0183	Belongs to the thiolase family
CCNA_01174	COG0583	DNA-binding transcription factor activity
CCNA_01175	COG1648	precorrin-2 dehydrogenase activity
CCNA_01175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CCNA_01177	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CCNA_01179	COG0175	sulfate reduction
CCNA_01187	COG1595	DNA-templated transcription, initiation
CCNA_01192	COG1940	carbohydrate kinase activity
CCNA_01195	COG1609	Transcriptional regulator
CCNA_01198	COG1091	dTDP-4-dehydrorhamnose reductase activity
CCNA_01199	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CCNA_01205	COG1131	(ABC) transporter
CCNA_01207	COG4585	Histidine kinase
CCNA_01208	COG2197	response regulator
CCNA_01210	COG1213	nucleotidyl transferase
CCNA_01212	COG0456	acetyltransferase
CCNA_01216	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CCNA_01220	COG0156	8-amino-7-oxononanoate synthase activity
CCNA_01221	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CCNA_01223	COG0318	PFAM AMP-dependent synthetase and ligase
CCNA_01227	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCNA_01228	COG1335	isochorismatase
CCNA_01230	COG3119	arylsulfatase activity
CCNA_01231	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CCNA_01234	COG1234	tRNA 3'-trailer cleavage
CCNA_01239	COG2205	protein histidine kinase activity
CCNA_01241	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CCNA_01242	COG0531	amino acid
CCNA_01243	COG1643	Atp-dependent helicase
CCNA_01245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CCNA_01246	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CCNA_01246	COG0116	Belongs to the methyltransferase superfamily
CCNA_01250	COG4139	cobalamin transport
CCNA_01251	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CCNA_01252	COG0741	lytic transglycosylase activity
CCNA_01253	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CCNA_01259	COG0235	Class ii aldolase
CCNA_01262	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCNA_01268	COG3474	cytochrome
CCNA_01272	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CCNA_01274	COG1012	belongs to the aldehyde dehydrogenase family
CCNA_01279	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CCNA_01281	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CCNA_01282	COG3386	PFAM SMP-30 Gluconolaconase
CCNA_01283	COG0673	inositol 2-dehydrogenase activity
CCNA_01287	COG2267	carboxylic ester hydrolase activity
CCNA_01288	COG2814	Major facilitator Superfamily
CCNA_01289	COG2363	Small membrane protein
CCNA_01295	COG0861	Integral membrane protein TerC family
CCNA_01298	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CCNA_01300	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CCNA_01301	COG0243	molybdopterin cofactor binding
CCNA_01305	COG0051	transcription antitermination factor activity, RNA binding
CCNA_01306	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CCNA_01311	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CCNA_01319	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CCNA_01326	COG0201	protein transport
CCNA_01335	COG1131	(ABC) transporter
CCNA_01342	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CCNA_01345	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_01349	COG3293	Transposase
CCNA_01352	COG2205	protein histidine kinase activity
CCNA_01353	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
CCNA_01354	COG0673	inositol 2-dehydrogenase activity
CCNA_01356	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCNA_01357	COG3962	Belongs to the TPP enzyme family
CCNA_01359	COG3718	enzyme involved in inositol metabolism
CCNA_01364	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CCNA_01367	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CCNA_01368	COG1960	acyl-CoA dehydrogenase activity
CCNA_01374	COG5265	(ABC) transporter
CCNA_01375	COG0346	lactoylglutathione lyase activity
CCNA_01376	COG0625	glutathione transferase activity
CCNA_01381	COG0525	valine-tRNA ligase activity
CCNA_01382	COG0318	PFAM AMP-dependent synthetase and ligase
CCNA_01387	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CCNA_01390	COG4941	Belongs to the sigma-70 factor family
CCNA_01393	COG0741	lytic transglycosylase activity
CCNA_01394	COG1573	uracil-dna glycosylase
CCNA_01399	COG0004	ammonium transporteR
CCNA_01400	COG0347	Belongs to the P(II) protein family
CCNA_01404	COG0751	glycine-tRNA ligase activity
CCNA_01409	COG0113	porphobilinogen synthase activity
CCNA_01410	COG2072	flavoprotein involved in K transport
CCNA_01412	COG1960	acyl-CoA dehydrogenase activity
CCNA_01413	COG0406	alpha-ribazole phosphatase activity
CCNA_01414	COG1024	Enoyl-CoA hydratase
CCNA_01417	COG0156	8-amino-7-oxononanoate synthase activity
CCNA_01418	COG4957	zinc ion binding
CCNA_01419	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CCNA_01421	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CCNA_01423	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CCNA_01425	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CCNA_01426	COG2201	protein-glutamate methylesterase activity
CCNA_01431	COG0416	fatty acid biosynthetic process
CCNA_01432	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CCNA_01440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CCNA_01444	COG3243	poly(R)-hydroxyalkanoic acid synthase
CCNA_01446	COG0436	Aminotransferase
CCNA_01449	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CCNA_01450	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CCNA_01450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CCNA_01451	COG1278	Cold shock
CCNA_01463	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCNA_01470	COG2010	Cytochrome c
CCNA_01473	COG2217	Heavy metal translocating P-type atpase
CCNA_01475	COG3047	cAMP biosynthetic process
CCNA_01477	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CCNA_01487	COG2186	Transcriptional regulator
CCNA_01488	COG0129	dihydroxy-acid dehydratase activity
CCNA_01490	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CCNA_01491	COG0626	cystathionine gamma-synthase activity
CCNA_01492	COG2897	thiosulfate sulfurtransferase activity
CCNA_01494	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CCNA_01495	COG0415	Belongs to the DNA photolyase family
CCNA_01499	COG0183	Belongs to the thiolase family
CCNA_01502	COG2354	Protein conserved in bacteria
CCNA_01506	COG1126	abc transporter atp-binding protein
CCNA_01507	COG0765	amino acid transport
CCNA_01508	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCNA_01513	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CCNA_01516	COG0778	Nitroreductase
CCNA_01522	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CCNA_01524	COG0859	PFAM glycosyl transferase family 9
CCNA_01524	COG0457	Tetratricopeptide repeat
CCNA_01526	COG5442	Flagellar protein FlaF
CCNA_01527	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCNA_01528	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCNA_01532	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCNA_01535	COG0629	single-stranded DNA binding
CCNA_01538	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCNA_01538	COG0574	Belongs to the PEP-utilizing enzyme family
CCNA_01539	COG1741	Belongs to the pirin family
CCNA_01541	COG0583	DNA-binding transcription factor activity
CCNA_01543	COG0443	Heat shock 70 kDa protein
CCNA_01545	COG2081	HI0933 family
CCNA_01550	COG0175	sulfate reduction
CCNA_01553	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CCNA_01554	COG0246	Mannitol dehydrogenase
CCNA_01555	COG2721	sulfolactate sulfo-lyase activity
CCNA_01556	COG1609	Transcriptional regulator
CCNA_01559	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_01560	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CCNA_01563	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCNA_01568	COG0475	glutathione-regulated potassium exporter activity
CCNA_01574	COG0431	NADPH-dependent FMN reductase
CCNA_01575	COG2133	pyrroloquinoline quinone binding
CCNA_01576	COG2271	Major facilitator Superfamily
CCNA_01578	COG3682	Transcriptional regulator
CCNA_01579	COG2989	Protein conserved in bacteria
CCNA_01580	COG3108	Peptidase M15
CCNA_01583	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CCNA_01584	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CCNA_01586	COG1131	(ABC) transporter
CCNA_01593	COG0006	proline dipeptidase activity
CCNA_01594	COG2264	protein methyltransferase activity
CCNA_01596	COG0210	DNA helicase
CCNA_01602	COG0625	glutathione transferase activity
CCNA_01606	COG0455	bacterial-type flagellum organization
CCNA_01608	COG1309	transcriptional regulator
CCNA_01609	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CCNA_01616	COG0772	Belongs to the SEDS family
CCNA_01618	COG1573	uracil-dna glycosylase
CCNA_01620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CCNA_01629	COG0681	Belongs to the peptidase S26 family
CCNA_01634	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CCNA_01635	COG1381	Involved in DNA repair and RecF pathway recombination
CCNA_01636	COG3540	Alkaline phosphatase
CCNA_01637	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CCNA_01639	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CCNA_01640	COG3321	synthase
CCNA_01640	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_01640	COG0604	alcohol dehydrogenase
CCNA_01644	COG1360	Flagellar Motor Protein
CCNA_01645	COG2084	Dehydrogenase
CCNA_01648	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CCNA_01650	COG2032	superoxide dismutase activity
CCNA_01651	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CCNA_01653	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CCNA_01659	COG0343	queuine tRNA-ribosyltransferase activity
CCNA_01664	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CCNA_01666	COG2205	protein histidine kinase activity
CCNA_01667	COG0745	RESPONSE REGULATOR receiver
CCNA_01669	COG4208	sulfate ABC transporter
CCNA_01670	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CCNA_01674	COG2308	Evidence 4 Homologs of previously reported genes of
CCNA_01679	COG1012	belongs to the aldehyde dehydrogenase family
CCNA_01680	COG3724	N-succinylarginine dihydrolase activity
CCNA_01684	COG3186	Phenylalanine-4-hydroxylase
CCNA_01686	COG0248	Ppx GppA phosphatase
CCNA_01687	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CCNA_01696	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CCNA_01699	COG1609	Transcriptional regulator
CCNA_01700	COG2211	Major facilitator Superfamily
CCNA_01702	COG0673	inositol 2-dehydrogenase activity
CCNA_01704	COG3474	cytochrome
CCNA_01714	COG1393	Belongs to the ArsC family
CCNA_01715	COG0546	phosphoglycolate phosphatase activity
CCNA_01721	COG1595	DNA-templated transcription, initiation
CCNA_01726	COG1160	GTP binding
CCNA_01728	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_01730	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CCNA_01733	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CCNA_01736	COG1309	transcriptional regulator
CCNA_01740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CCNA_01746	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CCNA_01750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CCNA_01751	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CCNA_01752	COG1561	YicC-like family, N-terminal region
CCNA_01753	COG0194	GDP metabolic process
CCNA_01755	COG3920	Histidine kinase
CCNA_01757	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CCNA_01758	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CCNA_01759	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCNA_01763	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CCNA_01769	COG0488	(ABC) transporter
CCNA_01774	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CCNA_01775	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CCNA_01776	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CCNA_01777	COG2205	protein histidine kinase activity
CCNA_01777	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCNA_01782	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CCNA_01794	COG1024	Enoyl-CoA hydratase
CCNA_01799	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CCNA_01800	COG0022	dehydrogenase e1 component
CCNA_01800	COG0508	dehydrogenase complex catalyzes the overall conversion of
CCNA_01803	COG0508	dehydrogenase complex catalyzes the overall conversion of
CCNA_01804	COG0386	Belongs to the glutathione peroxidase family
CCNA_01805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCNA_01807	COG0318	PFAM AMP-dependent synthetase and ligase
CCNA_01807	COG0204	Acyl-transferase
CCNA_01808	COG2267	carboxylic ester hydrolase activity
CCNA_01810	COG2867	negative regulation of translational initiation
CCNA_01811	COG1058	Belongs to the CinA family
CCNA_01811	COG1546	Belongs to the CinA family
CCNA_01813	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CCNA_01814	COG3852	Histidine kinase
CCNA_01815	COG2204	response regulator
CCNA_01816	COG5000	phosphorelay sensor kinase activity
CCNA_01817	COG2204	response regulator
CCNA_01820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CCNA_01821	COG3956	TIGRFAM MazG family protein
CCNA_01826	COG4206	TonB-dependent receptor
CCNA_01827	COG1492	cobalamin metabolic process
CCNA_01832	COG1472	Belongs to the glycosyl hydrolase 3 family
CCNA_01835	COG1136	(ABC) transporter
CCNA_01837	COG2826	transposase and inactivated derivatives, IS30 family
CCNA_01843	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CCNA_01845	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CCNA_01848	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CCNA_01849	COG1845	cytochrome c oxidase, subunit III
CCNA_01850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CCNA_01851	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CCNA_01852	COG0477	Major facilitator Superfamily
CCNA_01855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CCNA_01875	COG1960	acyl-CoA dehydrogenase activity
CCNA_01876	COG2072	flavoprotein involved in K transport
CCNA_01883	COG1960	acyl-CoA dehydrogenase activity
CCNA_01884	COG1960	acyl-CoA dehydrogenase activity
CCNA_01886	COG4771	TonB-dependent receptor
CCNA_01891	COG1024	Enoyl-CoA hydratase
CCNA_01892	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_01893	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CCNA_01894	COG2072	flavoprotein involved in K transport
CCNA_01895	COG2814	Major facilitator Superfamily
CCNA_01898	COG0084	hydrolase, TatD family'
CCNA_01900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CCNA_01902	COG0864	Transcriptional regulator
CCNA_01905	COG4770	biotin carboxylase activity
CCNA_01908	COG1174	glycine betaine transport
CCNA_01913	COG1733	regulation of RNA biosynthetic process
CCNA_01914	COG2813	Specifically methylates the guanine in position
CCNA_01915	COG1187	pseudouridine synthase activity
CCNA_01917	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CCNA_01920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CCNA_01922	COG2226	methyltransferase
CCNA_01923	COG0513	Belongs to the DEAD box helicase family
CCNA_01925	COG1012	belongs to the aldehyde dehydrogenase family
CCNA_01926	COG3706	GGDEF domain
CCNA_01927	COG1024	Enoyl-CoA hydratase
CCNA_01931	COG1309	transcriptional regulator
CCNA_01934	COG0316	Belongs to the HesB IscA family
CCNA_01936	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CCNA_01937	COG0719	Fe-S assembly protein
CCNA_01938	COG0396	ATPase activity
CCNA_01940	COG0719	Fe-S assembly protein
CCNA_01942	COG1959	2 iron, 2 sulfur cluster binding
CCNA_01943	COG2945	thiolester hydrolase activity
CCNA_01945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CCNA_01947	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CCNA_01948	COG0739	heme binding
CCNA_01951	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CCNA_01952	COG0860	N-Acetylmuramoyl-L-alanine amidase
CCNA_01954	COG1530	ribonuclease E activity
CCNA_01960	COG0511	ligase activity, forming carbon-carbon bonds
CCNA_01961	COG0439	Biotin carboxylase
CCNA_01966	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCNA_01969	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CCNA_01970	COG0149	triose-phosphate isomerase activity
CCNA_01971	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCNA_01972	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CCNA_01978	COG2226	methyltransferase
CCNA_01979	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CCNA_01980	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CCNA_01981	COG0658	competence protein
CCNA_01981	COG2333	competence protein COMEC
CCNA_01982	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CCNA_01983	COG0372	Belongs to the citrate synthase family
CCNA_01986	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CCNA_01987	COG3494	Protein of unknown function (DUF1009)
CCNA_01992	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCNA_01993	COG0750	zinc metalloprotease
CCNA_01995	COG0575	Belongs to the CDS family
CCNA_01996	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CCNA_01998	COG0528	UMP kinase activity
CCNA_02006	COG1136	(ABC) transporter
CCNA_02011	COG0346	lactoylglutathione lyase activity
CCNA_02013	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CCNA_02015	COG1007	ATP synthesis coupled electron transport
CCNA_02020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCNA_02022	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CCNA_02024	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CCNA_02029	COG0649	NAD binding
CCNA_02031	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCNA_02034	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCNA_02035	COG0297	glycogen (starch) synthase activity
CCNA_02043	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CCNA_02043	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CCNA_02044	COG0406	alpha-ribazole phosphatase activity
CCNA_02045	COG0183	Belongs to the thiolase family
CCNA_02046	COG0347	Belongs to the P(II) protein family
CCNA_02047	COG0174	glutamine synthetase
CCNA_02048	COG4771	TonB-dependent receptor
CCNA_02050	COG1228	amidohydrolase
CCNA_02051	COG0402	S-adenosylhomocysteine deaminase activity
CCNA_02052	COG0187	DNA topoisomerase II activity
CCNA_02054	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CCNA_02062	COG0497	DNA recombination
CCNA_02063	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCNA_02064	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CCNA_02065	COG0823	Involved in the tonB-independent uptake of proteins
CCNA_02065	COG1506	peptidase
CCNA_02068	COG3737	Protein of unknown function (DUF498/DUF598)
CCNA_02069	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCNA_02070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCNA_02071	COG1862	Preprotein translocase
CCNA_02074	COG0454	-acetyltransferase
CCNA_02080	COG0805	protein transport
CCNA_02083	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CCNA_02084	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CCNA_02085	COG1472	Belongs to the glycosyl hydrolase 3 family
CCNA_02088	COG0316	Belongs to the HesB IscA family
CCNA_02092	COG1280	lysine exporter protein (LysE YggA)
CCNA_02094	COG0673	inositol 2-dehydrogenase activity
CCNA_02095	COG2130	NADP-dependent
CCNA_02099	COG0534	Mate efflux family protein
CCNA_02101	COG0346	lactoylglutathione lyase activity
CCNA_02112	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CCNA_02113	COG1794	racemase activity, acting on amino acids and derivatives
CCNA_02118	COG1199	ATP-dependent helicase activity
CCNA_02118	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CCNA_02121	COG1201	RNA secondary structure unwinding
CCNA_02127	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CCNA_02127	COG0392	lysyltransferase activity
CCNA_02128	COG1960	acyl-CoA dehydrogenase activity
CCNA_02130	COG0469	pyruvate kinase activity
CCNA_02131	COG1472	Belongs to the glycosyl hydrolase 3 family
CCNA_02135	COG0363	glucosamine-6-phosphate deaminase activity
CCNA_02136	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CCNA_02142	COG4786	Flagellar basal body rod
CCNA_02143	COG4786	Flagellar basal body rod
CCNA_02144	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CCNA_02145	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CCNA_02150	COG0142	geranyltranstransferase activity
CCNA_02153	COG0123	including yeast histone deacetylase and acetoin utilization protein
CCNA_02166	COG1573	uracil-dna glycosylase
CCNA_02170	COG0625	glutathione transferase activity
CCNA_02171	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CCNA_02173	COG1136	(ABC) transporter
CCNA_02173	COG0577	efflux transmembrane transporter activity
CCNA_02178	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_02180	COG0489	protein tyrosine kinase activity
CCNA_02181	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CCNA_02182	COG3830	Belongs to the UPF0237 family
CCNA_02182	COG0560	Phosphoserine phosphatase
CCNA_02184	COG1546	Belongs to the CinA family
CCNA_02184	COG1058	Belongs to the CinA family
CCNA_02185	COG0028	Belongs to the TPP enzyme family
CCNA_02194	COG0114	fumarate hydratase activity
CCNA_02198	COG0142	geranyltranstransferase activity
CCNA_02203	COG2353	YceI-like domain
CCNA_02208	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CCNA_02210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CCNA_02215	COG1960	acyl-CoA dehydrogenase activity
CCNA_02220	COG2723	6-phospho-beta-galactosidase activity
CCNA_02221	COG0646	methionine synthase
CCNA_02221	COG1410	methionine synthase
CCNA_02222	COG0646	methionine synthase
CCNA_02222	COG1410	methionine synthase
CCNA_02225	COG2226	methyltransferase
CCNA_02230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CCNA_02231	COG0488	(ABC) transporter
CCNA_02233	COG0681	Belongs to the peptidase S26 family
CCNA_02243	COG1686	Belongs to the peptidase S11 family
CCNA_02244	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CCNA_02247	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CCNA_02251	COG1024	Enoyl-CoA hydratase
CCNA_02252	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CCNA_02254	COG1960	acyl-CoA dehydrogenase activity
CCNA_02256	COG2239	Acts as a magnesium transporter
CCNA_02258	COG0321	lipoyl(octanoyl) transferase activity
CCNA_02260	COG3152	Membrane
CCNA_02261	COG4770	biotin carboxylase activity
CCNA_02264	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CCNA_02277	COG4771	TonB-dependent receptor
CCNA_02280	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CCNA_02285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CCNA_02288	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CCNA_02292	COG0454	-acetyltransferase
CCNA_02292	COG0456	acetyltransferase
CCNA_02293	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CCNA_02294	COG0165	Argininosuccinate lyase
CCNA_02296	COG0019	diaminopimelate decarboxylase activity
CCNA_02297	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CCNA_02299	COG2884	Cell division ATP-binding protein ftsE
CCNA_02306	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CCNA_02307	COG0287	Prephenate dehydrogenase
CCNA_02310	COG2273	Hydrolase Family 16
CCNA_02310	COG5297	Belongs to the glycosyl hydrolase family 6
CCNA_02320	COG0717	Belongs to the dCTP deaminase family
CCNA_02322	COG2967	ApaG domain
CCNA_02325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CCNA_02326	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CCNA_02327	COG0842	Transport permease protein
CCNA_02332	COG0745	RESPONSE REGULATOR receiver
CCNA_02334	COG1396	sequence-specific DNA binding
CCNA_02341	COG0071	Belongs to the small heat shock protein (HSP20) family
CCNA_02346	COG0517	IMP dehydrogenase activity
CCNA_02346	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CCNA_02348	COG0456	acetyltransferase
CCNA_02355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CCNA_02358	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CCNA_02360	COG1215	transferase activity, transferring glycosyl groups
CCNA_02362	COG1956	GAF domain-containing protein
CCNA_02364	COG0840	transmembrane signaling receptor activity
CCNA_02367	COG1609	Transcriptional regulator
CCNA_02368	COG0366	Alpha amylase catalytic
CCNA_02373	COG2801	Transposase and inactivated derivatives
CCNA_02384	COG0318	PFAM AMP-dependent synthetase and ligase
CCNA_02385	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CCNA_02390	COG0546	phosphoglycolate phosphatase activity
CCNA_02394	COG0625	glutathione transferase activity
CCNA_02402	COG0840	transmembrane signaling receptor activity
CCNA_02403	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CCNA_02404	COG1127	ABC transporter
CCNA_02415	COG1396	sequence-specific DNA binding
CCNA_02416	COG0776	regulation of translation
CCNA_02420	COG0848	biopolymer transport protein
CCNA_02422	COG0300	oxidoreductase activity
CCNA_02426	COG1530	ribonuclease E activity
CCNA_02427	COG0424	maF-like protein
CCNA_02428	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CCNA_02431	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CCNA_02432	COG1953	Uracil, thiamine, allantoin
CCNA_02444	COG1446	asparaginase
CCNA_02446	COG0754	glutathionylspermidine amidase activity
CCNA_02448	COG3789	protein conserved in bacteria
CCNA_02453	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CCNA_02455	COG2119	membrane
CCNA_02464	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CCNA_02465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CCNA_02467	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CCNA_02469	COG3550	peptidyl-serine autophosphorylation
CCNA_02475	COG1802	Transcriptional regulator
CCNA_02481	COG4771	TonB-dependent receptor
CCNA_02482	COG2207	Transcriptional regulator
CCNA_02484	COG1024	Enoyl-CoA hydratase
CCNA_02485	COG1012	belongs to the aldehyde dehydrogenase family
CCNA_02490	COG0183	Belongs to the thiolase family
CCNA_02491	COG3485	protocatechuate 3,4-dioxygenase
CCNA_02492	COG3485	protocatechuate 3,4-dioxygenase
CCNA_02493	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CCNA_02494	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CCNA_02495	COG2814	Major facilitator Superfamily
CCNA_02498	COG0741	lytic transglycosylase activity
CCNA_02501	COG3451	type IV secretory pathway VirB4
CCNA_02504	COG2948	multi-organism process
CCNA_02505	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CCNA_02516	COG0625	glutathione transferase activity
CCNA_02518	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CCNA_02525	COG0540	Belongs to the ATCase OTCase family
CCNA_02526	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CCNA_02529	COG0758	DNA mediated transformation
CCNA_02530	COG2226	methyltransferase
CCNA_02535	COG1754	DNA topoisomerase type I activity
CCNA_02535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CCNA_02537	COG0557	exoribonuclease II activity
CCNA_02538	COG2755	lipolytic protein G-D-S-L family
CCNA_02539	COG0436	Aminotransferase
CCNA_02540	COG1473	amidohydrolase
CCNA_02547	COG0784	Response regulator, receiver
CCNA_02549	COG1940	carbohydrate kinase activity
CCNA_02550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CCNA_02555	COG0537	adenosine 5'-monophosphoramidase activity
CCNA_02558	COG0154	amidase activity
CCNA_02563	COG1960	acyl-CoA dehydrogenase activity
CCNA_02566	COG0308	aminopeptidase N
CCNA_02567	COG2202	Pas domain
CCNA_02567	COG2205	protein histidine kinase activity
CCNA_02568	COG1703	isobutyryl-CoA mutase activity
CCNA_02570	COG2814	Major facilitator Superfamily
CCNA_02571	COG2814	Major facilitator Superfamily
CCNA_02572	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CCNA_02576	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CCNA_02577	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CCNA_02580	COG1773	rubredoxin
CCNA_02583	COG0047	phosphoribosylformylglycinamidine synthase activity
CCNA_02586	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CCNA_02588	COG2234	aminopeptidase activity
CCNA_02589	COG0271	Belongs to the BolA IbaG family
CCNA_02591	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CCNA_02598	COG3668	Plasmid stabilization system
CCNA_02599	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CCNA_02600	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CCNA_02601	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CCNA_02602	COG0583	DNA-binding transcription factor activity
CCNA_02606	COG2198	Histidine kinase
CCNA_02606	COG2205	protein histidine kinase activity
CCNA_02606	COG0784	Response regulator, receiver
CCNA_02607	COG0538	isocitrate dehydrogenase activity
CCNA_02612	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CCNA_02617	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CCNA_02624	COG0849	cell division
CCNA_02626	COG1181	Belongs to the D-alanine--D-alanine ligase family
CCNA_02642	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CCNA_02650	COG3023	N-Acetylmuramoyl-L-alanine amidase
CCNA_02651	COG0697	spore germination
CCNA_02659	COG0784	Response regulator, receiver
CCNA_02665	COG1706	bacterial-type flagellum-dependent cell motility
CCNA_02666	COG3951	Flagellar rod assembly protein muramidase FlgJ
CCNA_02670	COG0488	(ABC) transporter
CCNA_02673	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CCNA_02674	COG3293	Transposase
CCNA_02677	COG0625	glutathione transferase activity
CCNA_02681	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CCNA_02683	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CCNA_02684	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CCNA_02687	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CCNA_02692	COG2353	YceI-like domain
CCNA_02699	COG0402	S-adenosylhomocysteine deaminase activity
CCNA_02701	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CCNA_02703	COG2351	hydroxyisourate hydrolase activity
CCNA_02705	COG1278	Cold shock
CCNA_02708	COG1959	2 iron, 2 sulfur cluster binding
CCNA_02709	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CCNA_02709	COG0617	tRNA 3'-terminal CCA addition
CCNA_02709	COG3620	sequence-specific DNA binding
CCNA_02712	COG1462	curli production assembly transport component CsgG
CCNA_02714	COG0488	(ABC) transporter
CCNA_02715	COG2205	protein histidine kinase activity
CCNA_02715	COG2198	Histidine kinase
CCNA_02715	COG0784	Response regulator, receiver
CCNA_02717	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CCNA_02717	COG1116	anion transmembrane transporter activity
CCNA_02718	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CCNA_02721	COG0612	Peptidase, M16
CCNA_02724	COG0667	Aldo Keto reductase
CCNA_02725	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CCNA_02727	COG1702	phosphate starvation-inducible protein PhoH
CCNA_02729	COG1297	OPT oligopeptide transporter protein
CCNA_02730	COG0625	glutathione transferase activity
CCNA_02734	COG1045	serine acetyltransferase
CCNA_02739	COG2801	Transposase and inactivated derivatives
CCNA_02739	COG3415	Transposase
CCNA_02750	COG2011	ABC-type metal ion transport system permease component
CCNA_02751	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CCNA_02752	COG0784	Response regulator, receiver
CCNA_02752	COG2205	protein histidine kinase activity
CCNA_02754	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CCNA_02755	COG1396	sequence-specific DNA binding
CCNA_02756	COG1546	Belongs to the CinA family
CCNA_02756	COG1058	Belongs to the CinA family
CCNA_02759	COG0024	Methionine aminopeptidase
CCNA_02762	COG2003	Belongs to the UPF0758 family
CCNA_02767	COG2948	multi-organism process
CCNA_02770	COG3846	protein secretion by the type IV secretion system
CCNA_02772	COG2801	Transposase and inactivated derivatives
CCNA_02773	COG0840	transmembrane signaling receptor activity
CCNA_02776	COG1492	cobalamin metabolic process
CCNA_02790	COG1595	DNA-templated transcription, initiation
CCNA_02792	COG4206	TonB-dependent receptor
CCNA_02810	COG1993	acr, cog1993
CCNA_02812	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CCNA_02814	COG3415	Transposase
CCNA_02814	COG2801	Transposase and inactivated derivatives
CCNA_02821	COG3550	peptidyl-serine autophosphorylation
CCNA_02822	COG1396	sequence-specific DNA binding
CCNA_02826	COG3547	Transposase (IS116 IS110 IS902 family)
CCNA_02828	COG2801	Transposase and inactivated derivatives
CCNA_02830	COG2003	Belongs to the UPF0758 family
CCNA_02833	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CCNA_02834	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CCNA_02837	COG1595	DNA-templated transcription, initiation
CCNA_02839	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CCNA_02843	COG3668	Plasmid stabilization system
CCNA_02847	COG3088	subunit of a heme lyase
CCNA_02848	COG1138	Cytochrome C-type biogenesis protein
CCNA_02850	COG4235	cytochrome complex assembly
CCNA_02860	COG0484	heat shock protein binding
CCNA_02877	COG4695	Portal protein
CCNA_02883	COG1231	oxidoreductase activity
CCNA_02884	COG1309	transcriptional regulator
CCNA_02889	COG0545	Peptidyl-prolyl cis-trans isomerase
CCNA_02893	COG3507	Belongs to the glycosyl hydrolase 43 family
CCNA_02902	COG3661	Belongs to the glycosyl hydrolase 67 family
CCNA_02903	COG4948	Mandelate Racemase Muconate Lactonizing
CCNA_02904	COG2186	Transcriptional regulator
CCNA_02917	COG0714	Associated with various cellular activities
CCNA_02924	COG3813	Protein conserved in bacteria
CCNA_02925	COG0505	Belongs to the CarA family
CCNA_02927	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_02929	COG1063	alcohol dehydrogenase
CCNA_02930	COG2852	Protein conserved in bacteria
CCNA_02935	COG0840	transmembrane signaling receptor activity
CCNA_02938	COG2885	chlorophyll binding
CCNA_02940	COG0840	transmembrane signaling receptor activity
CCNA_02942	COG3660	Nucleoside-diphosphate-sugar epimerase
CCNA_02945	COG2205	protein histidine kinase activity
CCNA_02945	COG0784	Response regulator, receiver
CCNA_02946	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CCNA_02954	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_02955	COG0730	response to heat
CCNA_02956	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CCNA_02957	COG0640	Transcriptional regulator
CCNA_02961	COG2089	acid synthase
CCNA_02964	COG0492	ferredoxin-NADP+ reductase activity
CCNA_02967	COG4191	Histidine kinase
CCNA_02967	COG0784	Response regulator, receiver
CCNA_02974	COG3668	Plasmid stabilization system
CCNA_02975	COG0322	excinuclease ABC activity
CCNA_02978	COG0642	Histidine kinase
CCNA_02980	COG3483	tryptophan 2,3-dioxygenase activity
CCNA_02981	COG1522	sequence-specific DNA binding
CCNA_02983	COG0463	Glycosyl transferase, family 2
CCNA_02994	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CCNA_02995	COG0625	glutathione transferase activity
CCNA_02997	COG1278	Cold shock
CCNA_03002	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CCNA_03004	COG0572	uridine kinase
CCNA_03007	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CCNA_03026	COG0745	RESPONSE REGULATOR receiver
CCNA_03029	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CCNA_03032	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CCNA_03040	COG4964	Belongs to the GSP D family
CCNA_03050	COG2365	Tyrosine phosphatase family
CCNA_03053	COG3384	dioxygenase
CCNA_03056	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
CCNA_03060	COG3422	double-strand break repair
CCNA_03070	COG1942	4-Oxalocrotonate Tautomerase
CCNA_03071	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCNA_03074	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_03076	COG0556	nucleotide-excision repair
CCNA_03079	COG3668	Plasmid stabilization system
CCNA_03080	COG3609	addiction module antidote protein, CC2985 family
CCNA_03083	COG2205	protein histidine kinase activity
CCNA_03083	COG0784	Response regulator, receiver
CCNA_03083	COG5002	protein histidine kinase activity
CCNA_03092	COG2124	cytochrome p450
CCNA_03094	COG2301	Belongs to the HpcH HpaI aldolase family
CCNA_03095	COG3264	Mechanosensitive ion channel
CCNA_03095	COG1196	nuclear chromosome segregation
CCNA_03097	COG0667	Aldo Keto reductase
CCNA_03100	COG2824	Alkylphosphonate utilization operon protein PhnA
CCNA_03101	COG4974	Belongs to the 'phage' integrase family
CCNA_03108	COG4206	TonB-dependent receptor
CCNA_03112	COG4536	flavin adenine dinucleotide binding
CCNA_03113	COG0671	phosphoesterase, PA-phosphatase related
CCNA_03120	COG0835	chemotaxis
CCNA_03124	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CCNA_03128	COG0697	spore germination
CCNA_03129	COG0739	heme binding
CCNA_03133	COG3657	addiction module killer protein
CCNA_03138	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CCNA_03140	COG0583	DNA-binding transcription factor activity
CCNA_03142	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CCNA_03143	COG3920	Histidine kinase
CCNA_03143	COG2202	Pas domain
CCNA_03144	COG0358	DNA primase activity
CCNA_03149	COG1472	Belongs to the glycosyl hydrolase 3 family
CCNA_03154	COG2202	Pas domain
CCNA_03154	COG3920	Histidine kinase
CCNA_03158	COG1477	protein flavinylation
CCNA_03160	COG0746	molybdenum cofactor guanylyltransferase activity
CCNA_03161	COG1609	Transcriptional regulator
CCNA_03162	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CCNA_03165	COG0477	Major facilitator Superfamily
CCNA_03171	COG0784	Response regulator, receiver
CCNA_03171	COG2205	protein histidine kinase activity
CCNA_03177	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CCNA_03177	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CCNA_03179	COG0446	pyridine nucleotide-disulphide oxidoreductase
CCNA_03179	COG1902	pentaerythritol trinitrate reductase activity
CCNA_03180	COG1024	Enoyl-CoA hydratase
CCNA_03181	COG0604	alcohol dehydrogenase
CCNA_03188	COG0596	Alpha beta hydrolase
CCNA_03191	COG5001	Diguanylate cyclase
CCNA_03191	COG3300	MHYT domain
CCNA_03193	COG0346	lactoylglutathione lyase activity
CCNA_03197	COG0596	Alpha beta hydrolase
CCNA_03204	COG3616	Alanine racemase, N-terminal domain
CCNA_03206	COG1760	l-serine dehydratase
CCNA_03209	COG0183	Belongs to the thiolase family
CCNA_03211	COG4948	Mandelate Racemase Muconate Lactonizing
CCNA_03217	COG1309	transcriptional regulator
CCNA_03222	COG4638	Rieske (2fe-2S)
CCNA_03223	COG1309	transcriptional regulator
CCNA_03225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CCNA_03226	COG0531	amino acid
CCNA_03228	COG0457	Tetratricopeptide repeat
CCNA_03229	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CCNA_03230	COG0174	glutamine synthetase
CCNA_03232	COG3668	Plasmid stabilization system
CCNA_03234	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CCNA_03235	COG3842	ATPase activity
CCNA_03236	COG1177	transmembrane transport
CCNA_03240	COG0174	glutamine synthetase
CCNA_03241	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CCNA_03242	COG1012	belongs to the aldehyde dehydrogenase family
CCNA_03243	COG1012	belongs to the aldehyde dehydrogenase family
CCNA_03244	COG2186	Transcriptional regulator
CCNA_03245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CCNA_03247	COG0840	transmembrane signaling receptor activity
CCNA_03250	COG2200	EAL domain
CCNA_03260	COG0720	synthase
CCNA_03261	COG0602	queuosine metabolic process
CCNA_03263	COG4771	TonB-dependent receptor
CCNA_03267	COG1396	sequence-specific DNA binding
CCNA_03269	COG0837	glucose binding
CCNA_03272	COG2202	Pas domain
CCNA_03272	COG3920	Histidine kinase
CCNA_03278	COG0579	oxidoreductase
CCNA_03281	COG1522	sequence-specific DNA binding
CCNA_03282	COG1741	Belongs to the pirin family
CCNA_03285	COG0598	Magnesium transport protein CorA
CCNA_03293	COG1024	Enoyl-CoA hydratase
CCNA_03293	COG1250	3-hydroxyacyl-CoA dehydrogenase
CCNA_03298	COG4771	TonB-dependent receptor
CCNA_03299	COG1538	Outer membrane efflux protein
CCNA_03303	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CCNA_03309	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CCNA_03320	COG4770	biotin carboxylase activity
CCNA_03322	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CCNA_03323	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CCNA_03326	COG0784	Response regulator, receiver
CCNA_03326	COG2198	Histidine kinase
CCNA_03326	COG2205	protein histidine kinase activity
CCNA_03328	COG0384	phenazine biosynthesis protein PhzF
CCNA_03331	COG0351	phosphomethylpyrimidine kinase
CCNA_03332	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CCNA_03333	COG4191	Histidine kinase
CCNA_03333	COG0784	Response regulator, receiver
CCNA_03335	COG0037	tRNA processing
CCNA_03337	COG2885	chlorophyll binding
CCNA_03338	COG0823	Involved in the tonB-independent uptake of proteins
CCNA_03342	COG0824	Thioesterase
CCNA_03346	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CCNA_03351	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CCNA_03353	COG1692	metallophosphoesterase
CCNA_03354	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CCNA_03367	COG0745	RESPONSE REGULATOR receiver
CCNA_03373	COG0352	thiamine-phosphate diphosphorylase activity
CCNA_03375	COG1595	DNA-templated transcription, initiation
CCNA_03378	COG0483	inositol monophosphate 1-phosphatase activity
CCNA_03379	COG3655	Transcriptional regulator
CCNA_03381	COG0584	glycerophosphoryl diester phosphodiesterase
CCNA_03383	COG1132	(ABC) transporter
CCNA_03387	COG1794	racemase activity, acting on amino acids and derivatives
CCNA_03391	COG3655	Transcriptional regulator
CCNA_03392	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CCNA_03393	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CCNA_03394	COG3706	GGDEF domain
CCNA_03402	COG3321	synthase
CCNA_03402	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_03402	COG0604	alcohol dehydrogenase
CCNA_03406	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CCNA_03407	COG1668	transmembrane transport
CCNA_03408	COG4152	abc transporter atp-binding protein
CCNA_03410	COG0739	heme binding
CCNA_03422	COG1122	ATPase activity
CCNA_03424	COG2204	response regulator
CCNA_03431	COG2951	lytic endotransglycosylase activity
CCNA_03436	COG2205	protein histidine kinase activity
CCNA_03440	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CCNA_03442	COG3293	Transposase
CCNA_03443	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CCNA_03444	COG4771	TonB-dependent receptor
CCNA_03446	COG0318	PFAM AMP-dependent synthetase and ligase
CCNA_03449	COG0500	methyltransferase
CCNA_03453	COG1309	transcriptional regulator
CCNA_03456	COG0657	acetylesterase activity
CCNA_03462	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CCNA_03465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CCNA_03468	COG0840	transmembrane signaling receptor activity
CCNA_03471	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CCNA_03479	COG1733	regulation of RNA biosynthetic process
CCNA_03480	COG0702	epimerase
CCNA_03482	COG0842	Transport permease protein
CCNA_03483	COG1131	(ABC) transporter
CCNA_03485	COG0330	HflC and HflK could
CCNA_03491	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_03492	COG1994	Peptidase M50
CCNA_03495	COG1028	Short-chain dehydrogenase reductase Sdr
CCNA_03501	COG0009	L-threonylcarbamoyladenylate synthase
CCNA_03502	COG3038	cytochrome b561
CCNA_03503	COG2353	YceI-like domain
CCNA_03504	COG1960	acyl-CoA dehydrogenase activity
CCNA_03505	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CCNA_03505	COG0678	peroxiredoxin activity
CCNA_03509	COG0612	Peptidase, M16
CCNA_03511	COG3346	SURF1 family
CCNA_03514	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CCNA_03516	COG0109	protoheme IX farnesyltransferase activity
CCNA_03517	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CCNA_03522	COG0312	modulator of DNA gyrase
CCNA_03524	COG3104	oligopeptide transport
CCNA_03529	COG2326	polyphosphate kinase activity
CCNA_03533	COG5265	(ABC) transporter
CCNA_03534	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CCNA_03536	COG2264	protein methyltransferase activity
CCNA_03543	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CCNA_03544	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CCNA_03545	COG0799	negative regulation of ribosome biogenesis
CCNA_03546	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CCNA_03548	COG0793	Belongs to the peptidase S41A family
CCNA_03549	COG4772	TonB-dependent receptor
CCNA_03556	COG2076	Multidrug Resistance protein
CCNA_03558	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CCNA_03560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CCNA_03567	COG1960	acyl-CoA dehydrogenase activity
CCNA_03569	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CCNA_03574	COG4771	TonB-dependent receptor
CCNA_03575	COG0183	Belongs to the thiolase family
CCNA_03577	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CCNA_03577	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CCNA_03578	COG0514	ATP-dependent DNA helicase (RecQ)
CCNA_03581	COG5006	permease, DMT superfamily
CCNA_03585	COG0745	RESPONSE REGULATOR receiver
CCNA_03591	COG0784	Response regulator, receiver
CCNA_03592	COG3040	lipid binding
CCNA_03594	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CCNA_03595	COG2226	methyltransferase
CCNA_03598	COG2205	protein histidine kinase activity
CCNA_03601	COG1272	protein, Hemolysin III
CCNA_03603	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CCNA_03607	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCNA_03607	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CCNA_03610	COG2226	methyltransferase
CCNA_03613	COG2030	dehydratase
CCNA_03619	COG3590	peptidase
CCNA_03625	COG0583	DNA-binding transcription factor activity
CCNA_03628	COG0124	histidyl-tRNA synthetase
CCNA_03637	COG3025	triphosphatase activity
CCNA_03639	COG0633	Ferredoxin
CCNA_03642	COG1053	succinate dehydrogenase
CCNA_03646	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CCNA_03648	COG0802	atpase or kinase
CCNA_03649	COG3178	'Phosphotransferase
CCNA_03650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CCNA_03658	COG0133	tryptophan synthase activity
CCNA_03659	COG0135	phosphoribosylanthranilate isomerase activity
CCNA_03660	COG5425	PFAM Usg family protein
CCNA_03663	COG0280	phosphate acetyltransferase
CCNA_03663	COG0281	malic enzyme
CCNA_03664	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CCNA_03672	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CCNA_03675	COG3920	Histidine kinase
CCNA_03677	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CCNA_03681	COG1131	(ABC) transporter
CCNA_03684	COG0288	reversible hydration of carbon dioxide
CCNA_03685	COG4953	penicillin-binding protein 1C
CCNA_03686	COG2373	Large extracellular alpha-helical protein
CCNA_03688	COG1522	sequence-specific DNA binding
CCNA_03689	COG0686	Belongs to the AlaDH PNT family
CCNA_03690	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CCNA_03695	COG1012	belongs to the aldehyde dehydrogenase family
CCNA_03696	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CCNA_03698	COG3011	Protein conserved in bacteria
CCNA_03699	COG0612	Peptidase, M16
CCNA_03702	COG0539	negative regulation of cytoplasmic translation
CCNA_03706	COG0071	Belongs to the small heat shock protein (HSP20) family
CCNA_03709	COG3293	Transposase
CCNA_03710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCNA_03711	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CCNA_03713	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CCNA_03714	COG1137	ATPase activity
CCNA_03717	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CCNA_03718	COG0702	epimerase
CCNA_03725	COG1793	dna ligase
CCNA_03727	COG0668	transmembrane transport
CCNA_03731	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CCNA_03732	COG2942	2-epimerase
CCNA_03738	COG0784	Response regulator, receiver
CCNA_03738	COG2205	protein histidine kinase activity
CCNA_03744	COG1088	dTDP-glucose 4,6-dehydratase activity
CCNA_03746	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CCNA_03749	COG0596	Alpha beta hydrolase
CCNA_03750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CCNA_03751	COG0545	Peptidyl-prolyl cis-trans isomerase
CCNA_03752	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CCNA_03753	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CCNA_03755	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CCNA_03755	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CCNA_03756	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CCNA_03757	COG0372	Belongs to the citrate synthase family
CCNA_03763	COG0123	including yeast histone deacetylase and acetoin utilization protein
CCNA_03764	COG1946	Acyl-CoA thioesterase
CCNA_03766	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CCNA_03768	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CCNA_03771	COG2030	dehydratase
CCNA_03774	COG2301	Belongs to the HpcH HpaI aldolase family
CCNA_03777	COG0667	Aldo Keto reductase
CCNA_03778	COG0670	Belongs to the BI1 family
CCNA_03781	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CCNA_03782	COG4133	protoheme IX ABC transporter activity
CCNA_03783	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CCNA_03786	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CCNA_03788	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CCNA_03792	COG2917	probably involved in intracellular septation
CCNA_03793	COG0552	protein localization to endoplasmic reticulum
CCNA_03798	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CCNA_03801	COG1505	serine-type exopeptidase activity
CCNA_03802	COG1505	serine-type exopeptidase activity
CCNA_03805	COG1695	Transcriptional regulator
CCNA_03806	COG2853	Lipoprotein
CCNA_03808	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CCNA_03809	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CCNA_03810	COG1127	ABC transporter
CCNA_03816	COG0339	signal peptide processing
CCNA_03817	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CCNA_03819	COG1674	ftsk spoiiie
CCNA_03824	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CCNA_03827	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CCNA_03832	COG1309	transcriptional regulator
CCNA_03833	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CCNA_03841	COG2267	carboxylic ester hydrolase activity
CCNA_03842	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CCNA_03843	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CCNA_03845	COG2169	Transcriptional regulator
CCNA_03845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CCNA_03847	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CCNA_03849	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCNA_03851	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CCNA_03852	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CCNA_03859	COG0745	RESPONSE REGULATOR receiver
CCNA_03861	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CCNA_03862	COG0352	thiamine-phosphate diphosphorylase activity
CCNA_03876	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CCNA_03877	COG1981	membrane
CCNA_03892	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CCNA_03903	COG3293	Transposase
CCNA_03905	COG4944	Protein of unknown function (DUF1109)
CCNA_03921	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CCNA_03989	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CCNA_03989	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CCNA_03998	COG0297	glycogen (starch) synthase activity
CCNA_R0096	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity