locus-tag	class	description
DSM104635_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DSM104635_RS00010	COG0592	DNA-directed DNA polymerase activity
DSM104635_RS00020	COG4999	Histidine kinase
DSM104635_RS00020	COG3850	Histidine kinase
DSM104635_RS00020	COG2205	protein histidine kinase activity
DSM104635_RS00020	COG3437	response regulator, receiver
DSM104635_RS00040	COG0187	DNA topoisomerase II activity
DSM104635_RS00190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DSM104635_RS00210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DSM104635_RS00220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSM104635_RS00225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DSM104635_RS00260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DSM104635_RS00275	COG1509	lysine 2,3-aminomutase activity
DSM104635_RS00290	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DSM104635_RS00295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DSM104635_RS00325	COG4139	cobalamin transport
DSM104635_RS00330	COG1120	ATPase activity
DSM104635_RS00335	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104635_RS00390	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DSM104635_RS00435	COG0668	transmembrane transport
DSM104635_RS00445	COG0667	Aldo Keto reductase
DSM104635_RS00455	COG0833	amino acid
DSM104635_RS00465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM104635_RS00470	COG1522	sequence-specific DNA binding
DSM104635_RS00475	COG0686	Belongs to the AlaDH PNT family
DSM104635_RS00510	COG3811	Belongs to the UPF0386 family
DSM104635_RS00515	COG4638	Rieske (2fe-2S)
DSM104635_RS00525	COG2827	Endonuclease containing a URI domain
DSM104635_RS00535	COG0589	response to stress
DSM104635_RS00545	COG0542	response to heat
DSM104635_RS00555	COG0671	phosphoesterase, PA-phosphatase related
DSM104635_RS00560	COG1741	Belongs to the pirin family
DSM104635_RS00565	COG2226	methyltransferase
DSM104635_RS00580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DSM104635_RS00585	COG0612	Peptidase, M16
DSM104635_RS00615	COG1024	Enoyl-CoA hydratase
DSM104635_RS00710	COG1024	Enoyl-CoA hydratase
DSM104635_RS00720	COG1024	Enoyl-CoA hydratase
DSM104635_RS00760	COG1021	2,3-dihydroxybenzoate-AMP ligase
DSM104635_RS00875	COG3307	-O-antigen
DSM104635_RS00885	COG1596	polysaccharide export
DSM104635_RS00895	COG3206	protein involved in exopolysaccharide biosynthesis
DSM104635_RS00895	COG0489	protein tyrosine kinase activity
DSM104635_RS00920	COG1596	polysaccharide export
DSM104635_RS00945	COG0367	asparagine synthase
DSM104635_RS00970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DSM104635_RS00995	COG2192	nodulation
DSM104635_RS01000	COG0463	Glycosyl transferase, family 2
DSM104635_RS01005	COG0297	glycogen (starch) synthase activity
DSM104635_RS01020	COG0297	glycogen (starch) synthase activity
DSM104635_RS01035	COG0275	rRNA processing
DSM104635_RS01040	COG2244	polysaccharide biosynthetic process
DSM104635_RS01050	COG0367	asparagine synthase
DSM104635_RS01110	COG2201	protein-glutamate methylesterase activity
DSM104635_RS01120	COG1858	cytochrome C peroxidase
DSM104635_RS01130	COG4771	TonB-dependent receptor
DSM104635_RS01170	COG0582	viral genome integration into host DNA
DSM104635_RS01180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM104635_RS01185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DSM104635_RS01200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DSM104635_RS01210	COG2962	Rard protein
DSM104635_RS01215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DSM104635_RS01230	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DSM104635_RS01235	COG2301	Belongs to the HpcH HpaI aldolase family
DSM104635_RS01250	COG3011	Protein conserved in bacteria
DSM104635_RS01260	COG2030	dehydratase
DSM104635_RS01290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DSM104635_RS01320	COG0674	pyruvate-flavodoxin oxidoreductase activity
DSM104635_RS01320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DSM104635_RS01335	COG1013	pyruvate-flavodoxin oxidoreductase activity
DSM104635_RS01350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM104635_RS01395	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DSM104635_RS01400	COG0583	DNA-binding transcription factor activity
DSM104635_RS01405	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS01410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM104635_RS01430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM104635_RS01435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DSM104635_RS01450	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DSM104635_RS01455	COG1137	ATPase activity
DSM104635_RS01480	COG2133	pyrroloquinoline quinone binding
DSM104635_RS01500	COG1446	asparaginase
DSM104635_RS01510	COG0346	lactoylglutathione lyase activity
DSM104635_RS01520	COG0625	glutathione transferase activity
DSM104635_RS01540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM104635_RS01575	COG0481	GTPase activity
DSM104635_RS01620	COG5507	3-demethylubiquinone-9 3-methyltransferase
DSM104635_RS01625	COG4771	TonB-dependent receptor
DSM104635_RS01635	COG0339	signal peptide processing
DSM104635_RS01695	COG4771	TonB-dependent receptor
DSM104635_RS01730	COG0673	inositol 2-dehydrogenase activity
DSM104635_RS01735	COG0673	inositol 2-dehydrogenase activity
DSM104635_RS01745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM104635_RS01750	COG3962	Belongs to the TPP enzyme family
DSM104635_RS01760	COG3718	enzyme involved in inositol metabolism
DSM104635_RS01765	COG2271	Major facilitator Superfamily
DSM104635_RS01770	COG0483	inositol monophosphate 1-phosphatase activity
DSM104635_RS01785	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS01800	COG4774	siderophore transport
DSM104635_RS01805	COG2130	NADP-dependent
DSM104635_RS01810	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS01835	COG0863	Belongs to the N(4) N(6)-methyltransferase family
DSM104635_RS01850	COG1538	Outer membrane efflux protein
DSM104635_RS01865	COG1309	transcriptional regulator
DSM104635_RS01880	COG1309	transcriptional regulator
DSM104635_RS01890	COG4774	siderophore transport
DSM104635_RS01910	COG0009	L-threonylcarbamoyladenylate synthase
DSM104635_RS01925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DSM104635_RS01940	COG0457	Tetratricopeptide repeat
DSM104635_RS01940	COG0859	PFAM glycosyl transferase family 9
DSM104635_RS01945	COG3507	Belongs to the glycosyl hydrolase 43 family
DSM104635_RS01955	COG0859	PFAM glycosyl transferase family 9
DSM104635_RS01955	COG0457	Tetratricopeptide repeat
DSM104635_RS01970	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS01975	COG1157	protein secretion by the type III secretion system
DSM104635_RS01985	COG0455	bacterial-type flagellum organization
DSM104635_RS02000	COG0667	Aldo Keto reductase
DSM104635_RS02010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DSM104635_RS02015	COG2204	response regulator
DSM104635_RS02020	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM104635_RS02030	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM104635_RS02035	COG1766	The M ring may be actively involved in energy transduction
DSM104635_RS02045	COG1749	Flagellar hook protein flgE
DSM104635_RS02050	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DSM104635_RS02070	COG0482	sulfurtransferase activity
DSM104635_RS02080	COG0183	Belongs to the thiolase family
DSM104635_RS02090	COG0529	Catalyzes the synthesis of activated sulfate
DSM104635_RS02090	COG2895	sulfate adenylyltransferase (ATP) activity
DSM104635_RS02095	COG0175	sulfate reduction
DSM104635_RS02130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSM104635_RS02135	COG0473	3-isopropylmalate dehydrogenase activity
DSM104635_RS02140	COG0066	3-isopropylmalate dehydratase activity
DSM104635_RS02145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSM104635_RS02150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM104635_RS02170	COG0129	dihydroxy-acid dehydratase activity
DSM104635_RS02180	COG0583	DNA-binding transcription factor activity
DSM104635_RS02185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DSM104635_RS02200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DSM104635_RS02210	COG0140	phosphoribosyl-ATP diphosphatase activity
DSM104635_RS02210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DSM104635_RS02215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM104635_RS02235	COG1476	TRANSCRIPTIONal
DSM104635_RS02260	COG3591	Belongs to the peptidase S1B family
DSM104635_RS02260	COG1864	DNA RNA non-specific endonuclease
DSM104635_RS02315	COG2816	NAD+ diphosphatase activity
DSM104635_RS02320	COG0667	Aldo Keto reductase
DSM104635_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS02330	COG1304	FMN binding
DSM104635_RS02350	COG2124	cytochrome p450
DSM104635_RS02370	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS02375	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
DSM104635_RS02380	COG2301	Belongs to the HpcH HpaI aldolase family
DSM104635_RS02385	COG0183	Belongs to the thiolase family
DSM104635_RS02390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM104635_RS02390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM104635_RS02400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM104635_RS02405	COG1024	Enoyl-CoA hydratase
DSM104635_RS02410	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS02415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DSM104635_RS02420	COG0045	succinate-CoA ligase (ADP-forming) activity
DSM104635_RS02425	COG2814	Major facilitator Superfamily
DSM104635_RS02435	COG1063	alcohol dehydrogenase
DSM104635_RS02440	COG0583	DNA-binding transcription factor activity
DSM104635_RS02445	COG2814	Major facilitator Superfamily
DSM104635_RS02450	COG0431	NADPH-dependent FMN reductase
DSM104635_RS02475	COG1024	Enoyl-CoA hydratase
DSM104635_RS02495	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS02500	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS02510	COG1024	Enoyl-CoA hydratase
DSM104635_RS02520	COG3618	amidohydrolase
DSM104635_RS02535	COG1012	belongs to the aldehyde dehydrogenase family
DSM104635_RS02540	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DSM104635_RS02545	COG2124	cytochrome p450
DSM104635_RS02550	COG5507	3-demethylubiquinone-9 3-methyltransferase
DSM104635_RS02560	COG0667	Aldo Keto reductase
DSM104635_RS02565	COG4221	oxidoreductase activity
DSM104635_RS02575	COG2267	carboxylic ester hydrolase activity
DSM104635_RS02590	COG2197	response regulator
DSM104635_RS02595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM104635_RS02625	COG2814	Major facilitator Superfamily
DSM104635_RS02650	COG1335	isochorismatase
DSM104635_RS02655	COG0667	Aldo Keto reductase
DSM104635_RS02665	COG0656	L-ascorbic acid biosynthetic process
DSM104635_RS02675	COG0583	DNA-binding transcription factor activity
DSM104635_RS02680	COG4977	sequence-specific DNA binding
DSM104635_RS02680	COG1917	Cupin 2, conserved barrel domain protein
DSM104635_RS02685	COG1741	Belongs to the pirin family
DSM104635_RS02730	COG1476	TRANSCRIPTIONal
DSM104635_RS02770	COG2204	response regulator
DSM104635_RS02775	COG4191	Histidine kinase
DSM104635_RS02780	COG1301	dicarboxylic acid transport
DSM104635_RS02795	COG4771	TonB-dependent receptor
DSM104635_RS02800	COG2124	cytochrome p450
DSM104635_RS02810	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104635_RS02835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM104635_RS02845	COG2207	Transcriptional regulator
DSM104635_RS02855	COG1024	Enoyl-CoA hydratase
DSM104635_RS02860	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS02865	COG1309	transcriptional regulator
DSM104635_RS02880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104635_RS02885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM104635_RS02895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DSM104635_RS02900	COG0022	dehydrogenase e1 component
DSM104635_RS02905	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM104635_RS02910	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DSM104635_RS02930	COG2267	carboxylic ester hydrolase activity
DSM104635_RS02935	COG1024	Enoyl-CoA hydratase
DSM104635_RS02945	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS02990	COG4771	TonB-dependent receptor
DSM104635_RS02995	COG0066	3-isopropylmalate dehydratase activity
DSM104635_RS03000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSM104635_RS03005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM104635_RS03010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104635_RS03015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM104635_RS03040	COG0431	NADPH-dependent FMN reductase
DSM104635_RS03045	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS03060	COG1902	pentaerythritol trinitrate reductase activity
DSM104635_RS03075	COG4771	TonB-dependent receptor
DSM104635_RS03080	COG0633	Ferredoxin
DSM104635_RS03100	COG1846	Transcriptional regulator
DSM104635_RS03110	COG4771	TonB-dependent receptor
DSM104635_RS03135	COG2814	Major facilitator Superfamily
DSM104635_RS03140	COG0129	dihydroxy-acid dehydratase activity
DSM104635_RS03150	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM104635_RS03160	COG2186	Transcriptional regulator
DSM104635_RS03165	COG2084	Dehydrogenase
DSM104635_RS03175	COG4771	TonB-dependent receptor
DSM104635_RS03190	COG1522	sequence-specific DNA binding
DSM104635_RS03255	COG2205	protein histidine kinase activity
DSM104635_RS03255	COG3437	response regulator, receiver
DSM104635_RS03255	COG3850	Histidine kinase
DSM104635_RS03255	COG4999	Histidine kinase
DSM104635_RS03260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DSM104635_RS03265	COG2151	metal-sulfur cluster biosynthetic enzyme
DSM104635_RS03270	COG3396	Phenylacetate-CoA oxygenase
DSM104635_RS03275	COG3460	Phenylacetate-CoA oxygenase
DSM104635_RS03285	COG3396	Phenylacetate-CoA oxygenase
DSM104635_RS03290	COG2050	protein possibly involved in aromatic compounds catabolism
DSM104635_RS03295	COG1024	Enoyl-CoA hydratase
DSM104635_RS03300	COG1012	belongs to the aldehyde dehydrogenase family
DSM104635_RS03300	COG2030	dehydratase
DSM104635_RS03305	COG1448	Aminotransferase
DSM104635_RS03310	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM104635_RS03315	COG0022	dehydrogenase e1 component
DSM104635_RS03325	COG2203	Gaf domain
DSM104635_RS03325	COG4251	negative regulation of phosphorylation
DSM104635_RS03325	COG3706	GGDEF domain
DSM104635_RS03325	COG5001	Diguanylate cyclase
DSM104635_RS03340	COG0784	Response regulator, receiver
DSM104635_RS03380	COG5487	UPF0391 membrane protein
DSM104635_RS03395	COG1024	Enoyl-CoA hydratase
DSM104635_RS03410	COG2197	response regulator
DSM104635_RS03420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DSM104635_RS03425	COG0602	queuosine metabolic process
DSM104635_RS03435	COG2197	response regulator
DSM104635_RS03440	COG1741	Belongs to the pirin family
DSM104635_RS03460	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS03465	COG2814	Major facilitator Superfamily
DSM104635_RS03490	COG0714	Associated with various cellular activities
DSM104635_RS03510	COG0494	nUDIX hydrolase
DSM104635_RS03515	COG4977	sequence-specific DNA binding
DSM104635_RS03515	COG1917	Cupin 2, conserved barrel domain protein
DSM104635_RS03520	COG0346	lactoylglutathione lyase activity
DSM104635_RS03545	COG0617	tRNA 3'-terminal CCA addition
DSM104635_RS03560	COG0408	coproporphyrinogen oxidase activity
DSM104635_RS03565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DSM104635_RS03575	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DSM104635_RS03575	COG2857	Cytochrome c1
DSM104635_RS03580	COG2857	Cytochrome c1
DSM104635_RS03580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DSM104635_RS03605	COG0740	serine-type endopeptidase activity
DSM104635_RS03610	COG1297	OPT oligopeptide transporter protein
DSM104635_RS03620	COG0352	thiamine-phosphate diphosphorylase activity
DSM104635_RS03630	COG3588	fructose-bisphosphate aldolase
DSM104635_RS03635	COG0126	phosphoglycerate kinase activity
DSM104635_RS03680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DSM104635_RS03700	COG0217	transcriptional regulatory protein
DSM104635_RS03730	COG2824	Alkylphosphonate utilization operon protein PhnA
DSM104635_RS03735	COG1968	undecaprenyl-diphosphatase activity
DSM104635_RS03755	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DSM104635_RS03760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DSM104635_RS03800	COG0438	transferase activity, transferring glycosyl groups
DSM104635_RS03810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DSM104635_RS03825	COG3485	protocatechuate 3,4-dioxygenase
DSM104635_RS03830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DSM104635_RS03835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DSM104635_RS03840	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DSM104635_RS03845	COG0072	phenylalanine-tRNA ligase activity
DSM104635_RS03845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM104635_RS03885	COG2301	Belongs to the HpcH HpaI aldolase family
DSM104635_RS03890	COG0825	malonyl-CoA metabolic process
DSM104635_RS03920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104635_RS03925	COG2076	Multidrug Resistance protein
DSM104635_RS03945	COG4974	Belongs to the 'phage' integrase family
DSM104635_RS03965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DSM104635_RS03970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DSM104635_RS03975	COG1253	flavin adenine dinucleotide binding
DSM104635_RS04005	COG0405	Gamma-glutamyltransferase
DSM104635_RS04010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DSM104635_RS04015	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS04025	COG0475	glutathione-regulated potassium exporter activity
DSM104635_RS04025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSM104635_RS04040	COG0783	Belongs to the Dps family
DSM104635_RS04045	COG0076	glutamate decarboxylase activity
DSM104635_RS04060	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104635_RS04065	COG2373	Large extracellular alpha-helical protein
DSM104635_RS04075	COG4953	penicillin-binding protein 1C
DSM104635_RS04115	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS04120	COG2205	protein histidine kinase activity
DSM104635_RS04130	COG1404	Belongs to the peptidase S8 family
DSM104635_RS04155	COG4172	Belongs to the ABC transporter superfamily
DSM104635_RS04165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM104635_RS04185	COG0545	Peptidyl-prolyl cis-trans isomerase
DSM104635_RS04225	COG0739	heme binding
DSM104635_RS04255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DSM104635_RS04255	COG2755	lipolytic protein G-D-S-L family
DSM104635_RS04270	COG0438	transferase activity, transferring glycosyl groups
DSM104635_RS04295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DSM104635_RS04300	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS04305	COG2244	polysaccharide biosynthetic process
DSM104635_RS04310	COG1215	transferase activity, transferring glycosyl groups
DSM104635_RS04320	COG3206	protein involved in exopolysaccharide biosynthesis
DSM104635_RS04320	COG0489	protein tyrosine kinase activity
DSM104635_RS04325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DSM104635_RS04330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DSM104635_RS04335	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DSM104635_RS04350	COG4310	Domain of unknown function (DUF2172)
DSM104635_RS04400	COG0489	protein tyrosine kinase activity
DSM104635_RS04400	COG3206	protein involved in exopolysaccharide biosynthesis
DSM104635_RS04405	COG1596	polysaccharide export
DSM104635_RS04420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DSM104635_RS04440	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DSM104635_RS04450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DSM104635_RS04460	COG1073	alpha beta
DSM104635_RS04470	COG3590	peptidase
DSM104635_RS04480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104635_RS04495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DSM104635_RS04500	COG0704	Plays a role in the regulation of phosphate uptake
DSM104635_RS04505	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS04540	COG2267	carboxylic ester hydrolase activity
DSM104635_RS04545	COG0183	Belongs to the thiolase family
DSM104635_RS04580	COG4106	trans-aconitate 2-methyltransferase activity
DSM104635_RS04585	COG4152	abc transporter atp-binding protein
DSM104635_RS04605	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DSM104635_RS04620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DSM104635_RS04630	COG5001	Diguanylate cyclase
DSM104635_RS04630	COG3447	MASE1 domain protein
DSM104635_RS04630	COG5002	protein histidine kinase activity
DSM104635_RS04665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104635_RS04700	COG0254	rRNA binding
DSM104635_RS04720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSM104635_RS04720	COG4651	solute:proton antiporter activity
DSM104635_RS04735	COG2204	response regulator
DSM104635_RS04760	COG3750	Belongs to the UPF0335 family
DSM104635_RS04770	COG0457	Tetratricopeptide repeat
DSM104635_RS04775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DSM104635_RS04785	COG2814	Major facilitator Superfamily
DSM104635_RS04790	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DSM104635_RS04800	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DSM104635_RS04800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM104635_RS04815	COG0483	inositol monophosphate 1-phosphatase activity
DSM104635_RS04830	COG0412	Dienelactone hydrolase
DSM104635_RS04845	COG2814	Major facilitator Superfamily
DSM104635_RS04850	COG0012	GTP binding
DSM104635_RS04870	COG0193	aminoacyl-tRNA hydrolase activity
DSM104635_RS04875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DSM104635_RS04885	COG3158	transport of potassium into the cell
DSM104635_RS04890	COG2205	protein histidine kinase activity
DSM104635_RS04920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DSM104635_RS04935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DSM104635_RS04945	COG2813	Specifically methylates the guanine in position
DSM104635_RS04985	COG2175	clavaminate synthase activity
DSM104635_RS05000	COG2205	protein histidine kinase activity
DSM104635_RS05010	COG0463	Glycosyl transferase, family 2
DSM104635_RS05015	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS05020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSM104635_RS05055	COG2201	protein-glutamate methylesterase activity
DSM104635_RS05075	COG1201	RNA secondary structure unwinding
DSM104635_RS05085	COG0513	Belongs to the DEAD box helicase family
DSM104635_RS05090	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DSM104635_RS05110	COG0730	response to heat
DSM104635_RS05125	COG0789	Transcriptional regulator
DSM104635_RS05130	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS05135	COG2852	Protein conserved in bacteria
DSM104635_RS05145	COG0183	Belongs to the thiolase family
DSM104635_RS05155	COG1024	Enoyl-CoA hydratase
DSM104635_RS05155	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM104635_RS05170	COG1902	pentaerythritol trinitrate reductase activity
DSM104635_RS05185	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DSM104635_RS05210	COG0513	Belongs to the DEAD box helicase family
DSM104635_RS05265	COG3047	cAMP biosynthetic process
DSM104635_RS05265	COG2885	chlorophyll binding
DSM104635_RS05325	COG0183	Belongs to the thiolase family
DSM104635_RS05350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DSM104635_RS05375	COG1272	protein, Hemolysin III
DSM104635_RS05395	COG0735	belongs to the Fur family
DSM104635_RS05410	COG2304	oxidoreductase activity
DSM104635_RS05440	COG2986	histidine ammonia-lyase
DSM104635_RS05445	COG0124	histidyl-tRNA synthetase
DSM104635_RS05450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DSM104635_RS05475	COG0459	protein refolding
DSM104635_RS05480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DSM104635_RS05505	COG1309	transcriptional regulator
DSM104635_RS05510	COG0386	Belongs to the glutathione peroxidase family
DSM104635_RS05515	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DSM104635_RS05530	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DSM104635_RS05540	COG0612	Peptidase, M16
DSM104635_RS05545	COG0612	Peptidase, M16
DSM104635_RS05565	COG1690	Belongs to the RtcB family
DSM104635_RS05575	COG1611	Belongs to the LOG family
DSM104635_RS05580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DSM104635_RS05590	COG0346	lactoylglutathione lyase activity
DSM104635_RS05595	COG0494	nUDIX hydrolase
DSM104635_RS05600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DSM104635_RS05605	COG0351	phosphomethylpyrimidine kinase
DSM104635_RS05605	COG0352	thiamine-phosphate diphosphorylase activity
DSM104635_RS05615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DSM104635_RS05625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM104635_RS05645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSM104635_RS05670	COG2982	Protein involved in outer membrane biogenesis
DSM104635_RS05680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DSM104635_RS05690	COG0564	pseudouridine synthase activity
DSM104635_RS05715	COG3739	integral membrane protein
DSM104635_RS05720	COG2852	Protein conserved in bacteria
DSM104635_RS05760	COG0215	cysteine-tRNA ligase activity
DSM104635_RS05765	COG0302	gtp cyclohydrolase
DSM104635_RS05810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DSM104635_RS05815	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DSM104635_RS05820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DSM104635_RS05825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DSM104635_RS05825	COG1017	nitric oxide dioxygenase activity
DSM104635_RS05860	COG0154	amidase activity
DSM104635_RS05865	COG2226	methyltransferase
DSM104635_RS05870	COG2226	methyltransferase
DSM104635_RS05880	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DSM104635_RS05910	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS05935	COG1322	Protein conserved in bacteria
DSM104635_RS05955	COG2816	NAD+ diphosphatase activity
DSM104635_RS05990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM104635_RS06015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DSM104635_RS06040	COG1794	racemase activity, acting on amino acids and derivatives
DSM104635_RS06045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM104635_RS06075	COG0006	proline dipeptidase activity
DSM104635_RS06105	COG2259	Doxx family
DSM104635_RS06110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DSM104635_RS06125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DSM104635_RS06135	COG0784	Response regulator, receiver
DSM104635_RS06135	COG2205	protein histidine kinase activity
DSM104635_RS06170	COG0242	peptide deformylase activity
DSM104635_RS06175	COG1295	ribonuclease BN
DSM104635_RS06180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM104635_RS06190	COG0101	tRNA pseudouridine synthase activity
DSM104635_RS06195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM104635_RS06200	COG2311	Membrane
DSM104635_RS06210	COG2171	N-acyltransferase activity
DSM104635_RS06225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DSM104635_RS06230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DSM104635_RS06235	COG0706	membrane insertase activity
DSM104635_RS06240	COG0594	ribonuclease P activity
DSM104635_RS06245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DSM104635_RS06250	COG4191	Histidine kinase
DSM104635_RS06260	COG0405	Gamma-glutamyltransferase
DSM104635_RS06265	COG3191	aminopeptidase activity
DSM104635_RS06320	COG0742	ribosomal rna small subunit methyltransferase
DSM104635_RS06325	COG0861	Integral membrane protein TerC family
DSM104635_RS06330	COG1187	pseudouridine synthase activity
DSM104635_RS06340	COG0590	tRNA wobble adenosine to inosine editing
DSM104635_RS06345	COG2030	dehydratase
DSM104635_RS06350	COG0196	riboflavin kinase activity
DSM104635_RS06355	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS06375	COG0572	uridine kinase
DSM104635_RS06385	COG3300	MHYT domain
DSM104635_RS06385	COG5001	Diguanylate cyclase
DSM104635_RS06400	COG3655	Transcriptional regulator
DSM104635_RS06430	COG0598	Magnesium transport protein CorA
DSM104635_RS06435	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DSM104635_RS06445	COG0151	Belongs to the GarS family
DSM104635_RS06450	COG0308	aminopeptidase N
DSM104635_RS06460	COG1570	exodeoxyribonuclease VII activity
DSM104635_RS06495	COG1663	tetraacyldisaccharide 4'-kinase activity
DSM104635_RS06500	COG1519	Transferase
DSM104635_RS06520	COG1132	(ABC) transporter
DSM104635_RS06535	COG0312	modulator of DNA gyrase
DSM104635_RS06555	COG2264	protein methyltransferase activity
DSM104635_RS06570	COG0640	Transcriptional regulator
DSM104635_RS06590	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DSM104635_RS06595	COG5265	(ABC) transporter
DSM104635_RS06605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DSM104635_RS06640	COG0312	modulator of DNA gyrase
DSM104635_RS06655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSM104635_RS06660	COG0109	protoheme IX farnesyltransferase activity
DSM104635_RS06670	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DSM104635_RS06685	COG3346	SURF1 family
DSM104635_RS06690	COG0612	Peptidase, M16
DSM104635_RS06695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSM104635_RS06700	COG1678	Uncharacterized ACR, COG1678
DSM104635_RS06710	COG0330	HflC and HflK could
DSM104635_RS06730	COG0328	RNA-DNA hybrid ribonuclease activity
DSM104635_RS06740	COG0572	uridine kinase
DSM104635_RS06745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DSM104635_RS06755	COG0018	arginyl-trna synthetase
DSM104635_RS06800	COG0494	nUDIX hydrolase
DSM104635_RS06815	COG0277	FAD linked oxidase domain protein
DSM104635_RS06825	COG2353	YceI-like domain
DSM104635_RS06835	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS06845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104635_RS06880	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS06910	COG1793	dna ligase
DSM104635_RS06920	COG1131	(ABC) transporter
DSM104635_RS06925	COG0842	Transport permease protein
DSM104635_RS06965	COG1722	exodeoxyribonuclease VII activity
DSM104635_RS06970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM104635_RS07000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104635_RS07000	COG1752	Esterase of the alpha-beta hydrolase superfamily
DSM104635_RS07010	COG1024	Enoyl-CoA hydratase
DSM104635_RS07050	COG3609	addiction module antidote protein, CC2985 family
DSM104635_RS07065	COG3483	tryptophan 2,3-dioxygenase activity
DSM104635_RS07075	COG0778	Nitroreductase
DSM104635_RS07085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM104635_RS07090	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DSM104635_RS07115	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DSM104635_RS07130	COG0537	adenosine 5'-monophosphoramidase activity
DSM104635_RS07165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DSM104635_RS07175	COG1058	Belongs to the CinA family
DSM104635_RS07175	COG1546	Belongs to the CinA family
DSM104635_RS07185	COG0456	acetyltransferase
DSM104635_RS07195	COG1063	alcohol dehydrogenase
DSM104635_RS07205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM104635_RS07220	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS07240	COG1051	belongs to the nudix hydrolase family
DSM104635_RS07245	COG1045	serine acetyltransferase
DSM104635_RS07255	COG1462	curli production assembly transport component CsgG
DSM104635_RS07275	COG0517	IMP dehydrogenase activity
DSM104635_RS07310	COG0438	transferase activity, transferring glycosyl groups
DSM104635_RS07330	COG3275	phosphorelay sensor kinase activity
DSM104635_RS07335	COG3279	Response regulator of the LytR AlgR family
DSM104635_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS07345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSM104635_RS07350	COG0730	response to heat
DSM104635_RS07370	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS07395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSM104635_RS07415	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS07445	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS07465	COG1573	uracil-dna glycosylase
DSM104635_RS07490	COG1840	ABC-type Fe3 transport system, periplasmic component
DSM104635_RS07505	COG0546	phosphoglycolate phosphatase activity
DSM104635_RS07510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DSM104635_RS07515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DSM104635_RS07550	COG0616	signal peptide processing
DSM104635_RS07565	COG0047	phosphoribosylformylglycinamidine synthase activity
DSM104635_RS07570	COG2124	cytochrome p450
DSM104635_RS07580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DSM104635_RS07600	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM104635_RS07605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DSM104635_RS07630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DSM104635_RS07640	COG2271	Major facilitator Superfamily
DSM104635_RS07645	COG2003	Belongs to the UPF0758 family
DSM104635_RS07650	COG0024	Methionine aminopeptidase
DSM104635_RS07665	COG3706	GGDEF domain
DSM104635_RS07665	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS07670	COG0784	Response regulator, receiver
DSM104635_RS07675	COG1940	carbohydrate kinase activity
DSM104635_RS07680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSM104635_RS07705	COG0557	exoribonuclease II activity
DSM104635_RS07710	COG1754	DNA topoisomerase type I activity
DSM104635_RS07710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DSM104635_RS07725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DSM104635_RS07750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DSM104635_RS07755	COG0540	Belongs to the ATCase OTCase family
DSM104635_RS07770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DSM104635_RS07775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM104635_RS07785	COG0154	amidase activity
DSM104635_RS07830	COG3108	Peptidase M15
DSM104635_RS07850	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DSM104635_RS07860	COG2885	chlorophyll binding
DSM104635_RS07885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM104635_RS07905	COG0625	glutathione transferase activity
DSM104635_RS07930	COG2308	Evidence 4 Homologs of previously reported genes of
DSM104635_RS07935	COG0848	biopolymer transport protein
DSM104635_RS07975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DSM104635_RS07985	COG2723	6-phospho-beta-galactosidase activity
DSM104635_RS07990	COG1609	Transcriptional regulator
DSM104635_RS08010	COG1175	transmembrane transport
DSM104635_RS08015	COG0395	ABC-type sugar transport system, permease component
DSM104635_RS08035	COG3119	arylsulfatase activity
DSM104635_RS08040	COG0596	Alpha beta hydrolase
DSM104635_RS08050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DSM104635_RS08075	COG0714	Associated with various cellular activities
DSM104635_RS08100	COG0492	ferredoxin-NADP+ reductase activity
DSM104635_RS08110	COG0625	glutathione transferase activity
DSM104635_RS08115	COG0730	response to heat
DSM104635_RS08120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM104635_RS08135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DSM104635_RS08145	COG5328	Belongs to the UPF0262 family
DSM104635_RS08155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DSM104635_RS08160	COG0300	oxidoreductase activity
DSM104635_RS08165	COG0424	maF-like protein
DSM104635_RS08170	COG1530	ribonuclease E activity
DSM104635_RS08175	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DSM104635_RS08205	COG0778	Nitroreductase
DSM104635_RS08215	COG0316	Belongs to the HesB IscA family
DSM104635_RS08220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DSM104635_RS08230	COG1472	Belongs to the glycosyl hydrolase 3 family
DSM104635_RS08235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DSM104635_RS08240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DSM104635_RS08245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM104635_RS08250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM104635_RS08255	COG0805	protein transport
DSM104635_RS08260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DSM104635_RS08265	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DSM104635_RS08320	COG0439	Biotin carboxylase
DSM104635_RS08325	COG0511	ligase activity, forming carbon-carbon bonds
DSM104635_RS08330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DSM104635_RS08350	COG2022	thiamine diphosphate biosynthetic process
DSM104635_RS08360	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DSM104635_RS08370	COG0534	Mate efflux family protein
DSM104635_RS08380	COG2130	NADP-dependent
DSM104635_RS08385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM104635_RS08400	COG2070	2-Nitropropane dioxygenase
DSM104635_RS08410	COG5265	(ABC) transporter
DSM104635_RS08505	COG0582	viral genome integration into host DNA
DSM104635_RS08525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM104635_RS08535	COG0525	valine-tRNA ligase activity
DSM104635_RS08550	COG2272	Belongs to the type-B carboxylesterase lipase family
DSM104635_RS08580	COG4783	chaperone-mediated protein folding
DSM104635_RS08630	COG2205	protein histidine kinase activity
DSM104635_RS08630	COG2198	Histidine kinase
DSM104635_RS08630	COG0784	Response regulator, receiver
DSM104635_RS08650	COG0300	oxidoreductase activity
DSM104635_RS08660	COG4952	isomerase
DSM104635_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS08665	COG3347	Dehydrogenase
DSM104635_RS08675	COG1304	FMN binding
DSM104635_RS08700	COG0277	FAD linked oxidase domain protein
DSM104635_RS08720	COG1304	FMN binding
DSM104635_RS08725	COG0583	DNA-binding transcription factor activity
DSM104635_RS08735	COG2814	Major facilitator Superfamily
DSM104635_RS08770	COG1802	Transcriptional regulator
DSM104635_RS08775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM104635_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS08795	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS08800	COG3345	alpha-galactosidase
DSM104635_RS08810	COG2771	luxR family
DSM104635_RS08825	COG4962	Type ii secretion system protein e
DSM104635_RS08830	COG3838	Conjugal transfer protein Trbc
DSM104635_RS08840	COG3451	type IV secretory pathway VirB4
DSM104635_RS08865	COG2948	multi-organism process
DSM104635_RS08875	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
DSM104635_RS08880	COG1431	PFAM Stem cell self-renewal protein Piwi
DSM104635_RS08900	COG0758	DNA mediated transformation
DSM104635_RS08920	COG4974	Belongs to the 'phage' integrase family
DSM104635_RS08930	COG0189	ligase activity
DSM104635_RS08930	COG2918	glutathione biosynthetic process
DSM104635_RS08950	COG2022	thiamine diphosphate biosynthetic process
DSM104635_RS08950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM104635_RS08985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DSM104635_RS08990	COG0235	Class ii aldolase
DSM104635_RS09000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104635_RS09005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM104635_RS09010	COG3474	cytochrome
DSM104635_RS09015	COG1404	Belongs to the peptidase S8 family
DSM104635_RS09020	COG1595	DNA-templated transcription, initiation
DSM104635_RS09050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM104635_RS09055	COG0456	acetyltransferase
DSM104635_RS09065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSM104635_RS09080	COG3360	Dodecin
DSM104635_RS09085	COG4206	TonB-dependent receptor
DSM104635_RS09090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DSM104635_RS09105	COG0051	transcription antitermination factor activity, RNA binding
DSM104635_RS09110	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DSM104635_RS09115	COG0088	Forms part of the polypeptide exit tunnel
DSM104635_RS09120	COG0089	rRNA binding
DSM104635_RS09125	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DSM104635_RS09130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DSM104635_RS09135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DSM104635_RS09140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DSM104635_RS09145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DSM104635_RS09150	COG0255	Belongs to the universal ribosomal protein uL29 family
DSM104635_RS09155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DSM104635_RS09160	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DSM104635_RS09165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DSM104635_RS09170	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DSM104635_RS09175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DSM104635_RS09180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DSM104635_RS09185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DSM104635_RS09190	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DSM104635_RS09195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DSM104635_RS09200	COG1841	ribosomal large subunit assembly
DSM104635_RS09205	COG0200	Binds to the 23S rRNA
DSM104635_RS09210	COG0201	protein transport
DSM104635_RS09215	COG0563	adenylate kinase activity
DSM104635_RS09225	COG1733	regulation of RNA biosynthetic process
DSM104635_RS09230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DSM104635_RS09235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DSM104635_RS09240	COG0202	RNA polymerase activity
DSM104635_RS09245	COG0203	ribosomal protein L17
DSM104635_RS09265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM104635_RS09275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DSM104635_RS09280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DSM104635_RS09290	COG0564	pseudouridine synthase activity
DSM104635_RS09300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DSM104635_RS09325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM104635_RS09355	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DSM104635_RS09365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104635_RS09375	COG1192	Involved in chromosome partitioning
DSM104635_RS09385	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DSM104635_RS09395	COG0189	ligase activity
DSM104635_RS09400	COG0302	gtp cyclohydrolase
DSM104635_RS09405	COG0471	metal ion transport
DSM104635_RS09445	COG1040	competence protein
DSM104635_RS09455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSM104635_RS09470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM104635_RS09475	COG0527	aspartate kinase activity
DSM104635_RS09490	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DSM104635_RS09500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DSM104635_RS09505	COG2890	protein-(glutamine-N5) methyltransferase activity
DSM104635_RS09515	COG2945	thiolester hydrolase activity
DSM104635_RS09520	COG1959	2 iron, 2 sulfur cluster binding
DSM104635_RS09525	COG1104	cysteine desulfurase activity
DSM104635_RS09530	COG0719	Fe-S assembly protein
DSM104635_RS09540	COG0396	ATPase activity
DSM104635_RS09545	COG0719	Fe-S assembly protein
DSM104635_RS09550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DSM104635_RS09560	COG0316	Belongs to the HesB IscA family
DSM104635_RS09570	COG1024	Enoyl-CoA hydratase
DSM104635_RS09575	COG3706	GGDEF domain
DSM104635_RS09580	COG1012	belongs to the aldehyde dehydrogenase family
DSM104635_RS09590	COG0513	Belongs to the DEAD box helicase family
DSM104635_RS09595	COG0187	DNA topoisomerase II activity
DSM104635_RS09610	COG2378	regulation of single-species biofilm formation
DSM104635_RS09615	COG0174	glutamine synthetase
DSM104635_RS09620	COG0347	Belongs to the P(II) protein family
DSM104635_RS09625	COG0406	alpha-ribazole phosphatase activity
DSM104635_RS09630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DSM104635_RS09630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DSM104635_RS09645	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSM104635_RS09650	COG0740	serine-type endopeptidase activity
DSM104635_RS09655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DSM104635_RS09660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM104635_RS09690	COG2897	thiosulfate sulfurtransferase activity
DSM104635_RS09695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSM104635_RS09700	COG0463	Glycosyl transferase, family 2
DSM104635_RS09705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DSM104635_RS09710	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DSM104635_RS09715	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DSM104635_RS09740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DSM104635_RS09755	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DSM104635_RS09760	COG1686	Belongs to the peptidase S11 family
DSM104635_RS09765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DSM104635_RS09775	COG0084	hydrolase, TatD family'
DSM104635_RS09790	COG3956	TIGRFAM MazG family protein
DSM104635_RS09810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DSM104635_RS09815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DSM104635_RS09820	COG1923	regulation of RNA biosynthetic process
DSM104635_RS09830	COG2204	response regulator
DSM104635_RS09835	COG5000	phosphorelay sensor kinase activity
DSM104635_RS09840	COG2204	response regulator
DSM104635_RS09845	COG3852	Histidine kinase
DSM104635_RS09850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSM104635_RS09855	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DSM104635_RS09855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DSM104635_RS09865	COG1058	Belongs to the CinA family
DSM104635_RS09865	COG1546	Belongs to the CinA family
DSM104635_RS09875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DSM104635_RS09880	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104635_RS09880	COG0204	Acyl-transferase
DSM104635_RS09895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM104635_RS09900	COG2095	MarC family integral membrane protein
DSM104635_RS09920	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM104635_RS09945	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM104635_RS09945	COG0022	dehydrogenase e1 component
DSM104635_RS09960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DSM104635_RS09970	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DSM104635_RS09980	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM104635_RS09990	COG0659	secondary active sulfate transmembrane transporter activity
DSM104635_RS09995	COG0148	phosphopyruvate hydratase activity
DSM104635_RS10005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DSM104635_RS10010	COG0517	IMP dehydrogenase activity
DSM104635_RS10050	COG0149	triose-phosphate isomerase activity
DSM104635_RS10060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DSM104635_RS10075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM104635_RS10080	COG0134	indole-3-glycerol-phosphate synthase activity
DSM104635_RS10085	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DSM104635_RS10095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM104635_RS10100	COG0372	Belongs to the citrate synthase family
DSM104635_RS10105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM104635_RS10110	COG3494	Protein of unknown function (DUF1009)
DSM104635_RS10115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM104635_RS10120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM104635_RS10125	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM104635_RS10140	COG0750	zinc metalloprotease
DSM104635_RS10145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DSM104635_RS10150	COG0575	Belongs to the CDS family
DSM104635_RS10155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DSM104635_RS10160	COG0233	cytoplasmic translational termination
DSM104635_RS10165	COG0528	UMP kinase activity
DSM104635_RS10170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DSM104635_RS10175	COG0052	Belongs to the universal ribosomal protein uS2 family
DSM104635_RS10195	COG0587	DNA-directed DNA polymerase activity
DSM104635_RS10200	COG1136	(ABC) transporter
DSM104635_RS10205	COG4591	ABC-type transport system involved in lipoprotein release permease component
DSM104635_RS10220	COG0346	lactoylglutathione lyase activity
DSM104635_RS10230	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DSM104635_RS10240	COG1007	ATP synthesis coupled electron transport
DSM104635_RS10255	COG0713	ATP synthesis coupled electron transport
DSM104635_RS10265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104635_RS10275	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DSM104635_RS10290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DSM104635_RS10300	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DSM104635_RS10320	COG0649	NAD binding
DSM104635_RS10335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104635_RS10340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104635_RS10370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104635_RS10400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSM104635_RS10440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DSM104635_RS10440	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DSM104635_RS10445	COG1494	fructose-1,6-bisphosphatase
DSM104635_RS10450	COG0436	Aminotransferase
DSM104635_RS10460	COG3243	poly(R)-hydroxyalkanoic acid synthase
DSM104635_RS10465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DSM104635_RS10475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DSM104635_RS10480	COG1612	heme a metabolic process
DSM104635_RS10495	COG1877	trehalose-phosphatase activity
DSM104635_RS10500	COG3387	PFAM Glycoside hydrolase 15-related
DSM104635_RS10505	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DSM104635_RS10520	COG0776	regulation of translation
DSM104635_RS10525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM104635_RS10530	COG0416	fatty acid biosynthetic process
DSM104635_RS10545	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DSM104635_RS10555	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DSM104635_RS10560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM104635_RS10565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DSM104635_RS10570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM104635_RS10570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM104635_RS10580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM104635_RS10580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM104635_RS10585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DSM104635_RS10590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSM104635_RS10595	COG4957	zinc ion binding
DSM104635_RS10605	COG0156	8-amino-7-oxononanoate synthase activity
DSM104635_RS10610	COG0113	porphobilinogen synthase activity
DSM104635_RS10635	COG2084	Dehydrogenase
DSM104635_RS10645	COG1360	Flagellar Motor Protein
DSM104635_RS10660	COG3590	peptidase
DSM104635_RS10680	COG0501	Belongs to the peptidase M48B family
DSM104635_RS10685	COG1704	LemA family
DSM104635_RS10690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSM104635_RS10695	COG1381	Involved in DNA repair and RecF pathway recombination
DSM104635_RS10705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DSM104635_RS10710	COG0571	ribonuclease III activity
DSM104635_RS10715	COG0681	Belongs to the peptidase S26 family
DSM104635_RS10720	COG0736	holo-[acyl-carrier-protein] synthase activity
DSM104635_RS10725	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DSM104635_RS10730	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DSM104635_RS10745	COG1758	RNA polymerase activity
DSM104635_RS10750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DSM104635_RS10755	COG1573	uracil-dna glycosylase
DSM104635_RS10760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DSM104635_RS10765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM104635_RS10780	COG1643	Atp-dependent helicase
DSM104635_RS10790	COG0343	queuine tRNA-ribosyltransferase activity
DSM104635_RS10795	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DSM104635_RS10800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DSM104635_RS10805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DSM104635_RS10810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DSM104635_RS10815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSM104635_RS10820	COG2032	superoxide dismutase activity
DSM104635_RS10830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM104635_RS10835	COG0629	single-stranded DNA binding
DSM104635_RS10840	COG3384	dioxygenase
DSM104635_RS10850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DSM104635_RS10870	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DSM104635_RS10875	COG1505	serine-type exopeptidase activity
DSM104635_RS10890	COG2202	Pas domain
DSM104635_RS10890	COG2205	protein histidine kinase activity
DSM104635_RS10895	COG0579	oxidoreductase
DSM104635_RS10900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DSM104635_RS10905	COG0228	four-way junction DNA binding
DSM104635_RS10910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DSM104635_RS10920	COG0336	Belongs to the RNA methyltransferase TrmD family
DSM104635_RS10935	COG0335	large ribosomal subunit rRNA binding
DSM104635_RS10945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM104635_RS10950	COG0552	protein localization to endoplasmic reticulum
DSM104635_RS10965	COG2917	probably involved in intracellular septation
DSM104635_RS10975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104635_RS10985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM104635_RS10990	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM104635_RS10995	COG4133	protoheme IX ABC transporter activity
DSM104635_RS11010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DSM104635_RS11045	COG0670	Belongs to the BI1 family
DSM104635_RS11050	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DSM104635_RS11070	COG1999	signal sequence binding
DSM104635_RS11095	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DSM104635_RS11110	COG3876	Protein conserved in bacteria
DSM104635_RS11120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DSM104635_RS11135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSM104635_RS11160	COG1309	transcriptional regulator
DSM104635_RS11180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DSM104635_RS11185	COG0860	N-Acetylmuramoyl-L-alanine amidase
DSM104635_RS11195	COG1530	ribonuclease E activity
DSM104635_RS11200	COG4783	chaperone-mediated protein folding
DSM104635_RS11220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM104635_RS11225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM104635_RS11240	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM104635_RS11245	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DSM104635_RS11270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM104635_RS11285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DSM104635_RS11300	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DSM104635_RS11315	COG0248	Ppx GppA phosphatase
DSM104635_RS11320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DSM104635_RS11335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DSM104635_RS11340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DSM104635_RS11360	COG0105	UTP biosynthetic process
DSM104635_RS11390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM104635_RS11410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104635_RS11415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DSM104635_RS11420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DSM104635_RS11425	COG2353	YceI-like domain
DSM104635_RS11430	COG0194	GDP metabolic process
DSM104635_RS11435	COG1561	YicC-like family, N-terminal region
DSM104635_RS11445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DSM104635_RS11450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM104635_RS11455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DSM104635_RS11475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DSM104635_RS11505	COG0360	Binds together with S18 to 16S ribosomal RNA
DSM104635_RS11510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DSM104635_RS11515	COG0359	binds to the 23S rRNA
DSM104635_RS11530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DSM104635_RS11540	COG1127	ABC transporter
DSM104635_RS11550	COG0386	Belongs to the glutathione peroxidase family
DSM104635_RS11570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DSM104635_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS11585	COG2081	HI0933 family
DSM104635_RS11595	COG1160	GTP binding
DSM104635_RS11610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DSM104635_RS11620	COG1595	DNA-templated transcription, initiation
DSM104635_RS11630	COG0640	Transcriptional regulator
DSM104635_RS11670	COG1393	Belongs to the ArsC family
DSM104635_RS11710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DSM104635_RS11710	COG0519	Catalyzes the synthesis of GMP from XMP
DSM104635_RS11720	COG2818	Glycosylase
DSM104635_RS11730	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DSM104635_RS11750	COG3657	addiction module killer protein
DSM104635_RS11755	COG3724	N-succinylarginine dihydrolase activity
DSM104635_RS11760	COG1012	belongs to the aldehyde dehydrogenase family
DSM104635_RS11790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DSM104635_RS11850	COG0514	ATP-dependent DNA helicase (RecQ)
DSM104635_RS11865	COG3743	rRNA binding
DSM104635_RS11865	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM104635_RS11870	COG2885	chlorophyll binding
DSM104635_RS11880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSM104635_RS11885	COG0116	Belongs to the methyltransferase superfamily
DSM104635_RS11885	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DSM104635_RS11890	COG1024	Enoyl-CoA hydratase
DSM104635_RS11895	COG0587	DNA-directed DNA polymerase activity
DSM104635_RS11900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSM104635_RS11910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSM104635_RS11930	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS11945	COG0308	aminopeptidase N
DSM104635_RS11950	COG2205	protein histidine kinase activity
DSM104635_RS11950	COG2202	Pas domain
DSM104635_RS11970	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DSM104635_RS11975	COG3850	Histidine kinase
DSM104635_RS11975	COG0642	Histidine kinase
DSM104635_RS11985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM104635_RS11990	COG3088	subunit of a heme lyase
DSM104635_RS11995	COG1138	Cytochrome C-type biogenesis protein
DSM104635_RS12000	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DSM104635_RS12015	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS12045	COG4695	Portal protein
DSM104635_RS12060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DSM104635_RS12080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DSM104635_RS12095	COG2205	protein histidine kinase activity
DSM104635_RS12105	COG2166	iron-sulfur cluster assembly
DSM104635_RS12135	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104635_RS12205	COG0848	biopolymer transport protein
DSM104635_RS12210	COG0848	biopolymer transport protein
DSM104635_RS12220	COG0271	Belongs to the BolA IbaG family
DSM104635_RS12225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DSM104635_RS12230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM104635_RS12240	COG2326	polyphosphate kinase activity
DSM104635_RS12285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM104635_RS12295	COG2205	protein histidine kinase activity
DSM104635_RS12295	COG4999	Histidine kinase
DSM104635_RS12295	COG3850	Histidine kinase
DSM104635_RS12295	COG3437	response regulator, receiver
DSM104635_RS12300	COG0346	lactoylglutathione lyase activity
DSM104635_RS12320	COG0538	isocitrate dehydrogenase activity
DSM104635_RS12335	COG1024	Enoyl-CoA hydratase
DSM104635_RS12345	COG0456	acetyltransferase
DSM104635_RS12350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSM104635_RS12355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DSM104635_RS12375	COG0667	Aldo Keto reductase
DSM104635_RS12395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DSM104635_RS12400	COG1684	flagellar biosynthetic protein fliR
DSM104635_RS12405	COG1987	bacterial-type flagellum assembly
DSM104635_RS12410	COG1338	Plays a role in the flagellum-specific transport system
DSM104635_RS12415	COG3190	flagellar
DSM104635_RS12425	COG1558	bacterial-type flagellum-dependent cell motility
DSM104635_RS12430	COG1677	Flagellar hook-basal body complex protein FliE
DSM104635_RS12440	COG5487	UPF0391 membrane protein
DSM104635_RS12480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DSM104635_RS12500	COG2239	Acts as a magnesium transporter
DSM104635_RS12505	COG1937	Protein conserved in bacteria
DSM104635_RS12540	COG0321	lipoyl(octanoyl) transferase activity
DSM104635_RS12560	COG1671	Belongs to the UPF0178 family
DSM104635_RS12575	COG1234	tRNA 3'-trailer cleavage
DSM104635_RS12595	COG1192	Involved in chromosome partitioning
DSM104635_RS12610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM104635_RS12645	COG4166	transmembrane transport
DSM104635_RS12650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM104635_RS12655	COG0601	transmembrane transport
DSM104635_RS12670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104635_RS12680	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104635_RS12685	COG0259	pyridoxamine-phosphate oxidase activity
DSM104635_RS12690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DSM104635_RS12700	COG0154	amidase activity
DSM104635_RS12705	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DSM104635_RS12730	COG1024	Enoyl-CoA hydratase
DSM104635_RS12740	COG2983	Belongs to the UPF0260 family
DSM104635_RS12745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DSM104635_RS12760	COG0154	amidase activity
DSM104635_RS12780	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DSM104635_RS12785	COG0418	dihydroorotase activity
DSM104635_RS12810	COG0438	transferase activity, transferring glycosyl groups
DSM104635_RS12850	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DSM104635_RS12880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DSM104635_RS12890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DSM104635_RS12900	COG3813	Protein conserved in bacteria
DSM104635_RS12915	COG4221	oxidoreductase activity
DSM104635_RS12925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM104635_RS12925	COG0574	Belongs to the PEP-utilizing enzyme family
DSM104635_RS12930	COG0751	glycine-tRNA ligase activity
DSM104635_RS12940	COG0752	glycyl-tRNA synthetase alpha subunit
DSM104635_RS12945	COG2267	carboxylic ester hydrolase activity
DSM104635_RS12960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DSM104635_RS12975	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DSM104635_RS12995	COG1194	a g-specific adenine glycosylase
DSM104635_RS13030	COG0356	it plays a direct role in the translocation of protons across the membrane
DSM104635_RS13035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM104635_RS13040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DSM104635_RS13045	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DSM104635_RS13065	COG1215	transferase activity, transferring glycosyl groups
DSM104635_RS13070	COG0384	phenazine biosynthesis protein PhzF
DSM104635_RS13075	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM104635_RS13085	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSM104635_RS13090	COG0509	glycine decarboxylation via glycine cleavage system
DSM104635_RS13095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM104635_RS13105	COG0142	geranyltranstransferase activity
DSM104635_RS13110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM104635_RS13115	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DSM104635_RS13135	COG1573	uracil-dna glycosylase
DSM104635_RS13140	COG0741	lytic transglycosylase activity
DSM104635_RS13170	COG4786	Flagellar basal body rod
DSM104635_RS13175	COG4786	Flagellar basal body rod
DSM104635_RS13185	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DSM104635_RS13210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DSM104635_RS13220	COG1706	bacterial-type flagellum-dependent cell motility
DSM104635_RS13225	COG3951	Flagellar rod assembly protein muramidase FlgJ
DSM104635_RS13250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSM104635_RS13255	COG5442	Flagellar protein FlaF
DSM104635_RS13260	COG5443	negative regulation of bacterial-type flagellum assembly
DSM104635_RS13270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM104635_RS13280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM104635_RS13305	COG0494	nUDIX hydrolase
DSM104635_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS13355	COG3300	MHYT domain
DSM104635_RS13355	COG5001	Diguanylate cyclase
DSM104635_RS13365	COG3300	MHYT domain
DSM104635_RS13365	COG5001	Diguanylate cyclase
DSM104635_RS13370	COG0784	Response regulator, receiver
DSM104635_RS13405	COG1127	ABC transporter
DSM104635_RS13410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DSM104635_RS13425	COG0772	Belongs to the SEDS family
DSM104635_RS13430	COG0768	penicillin binding
DSM104635_RS13475	COG2208	phosphoserine phosphatase activity
DSM104635_RS13475	COG2770	Histidine kinase
DSM104635_RS13480	COG1366	Belongs to the anti-sigma-factor antagonist family
DSM104635_RS13485	COG2205	protein histidine kinase activity
DSM104635_RS13485	COG0784	Response regulator, receiver
DSM104635_RS13500	COG3239	Fatty acid desaturase
DSM104635_RS13510	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DSM104635_RS13520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DSM104635_RS13555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DSM104635_RS13560	COG0560	Phosphoserine phosphatase
DSM104635_RS13580	COG0330	HflC and HflK could
DSM104635_RS13585	COG0330	HflC and HflK could
DSM104635_RS13590	COG0489	protein tyrosine kinase activity
DSM104635_RS13615	COG0469	pyruvate kinase activity
DSM104635_RS13625	COG3386	PFAM SMP-30 Gluconolaconase
DSM104635_RS13635	COG4589	Belongs to the CDS family
DSM104635_RS13675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DSM104635_RS13685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DSM104635_RS13715	COG0114	fumarate hydratase activity
DSM104635_RS13735	COG3152	Membrane
DSM104635_RS13745	COG0640	Transcriptional regulator
DSM104635_RS13770	COG2264	protein methyltransferase activity
DSM104635_RS13780	COG0006	proline dipeptidase activity
DSM104635_RS13780	COG0006	proline dipeptidase activity
DSM104635_RS13800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DSM104635_RS13805	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM104635_RS13810	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DSM104635_RS13835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DSM104635_RS13845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM104635_RS13880	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DSM104635_RS13885	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM104635_RS13900	COG0626	cystathionine gamma-synthase activity
DSM104635_RS13910	COG0025	NhaP-type Na H and K H
DSM104635_RS13915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DSM104635_RS13950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DSM104635_RS13970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DSM104635_RS13980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DSM104635_RS13985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM104635_RS13995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSM104635_RS14010	COG0275	rRNA processing
DSM104635_RS14030	COG3023	N-Acetylmuramoyl-L-alanine amidase
DSM104635_RS14040	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DSM104635_RS14045	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DSM104635_RS14125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DSM104635_RS14160	COG4964	Belongs to the GSP D family
DSM104635_RS14195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM104635_RS14220	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DSM104635_RS14230	COG0657	acetylesterase activity
DSM104635_RS14235	COG0077	Prephenate dehydratase
DSM104635_RS14235	COG1605	Chorismate mutase
DSM104635_RS14240	COG1595	DNA-templated transcription, initiation
DSM104635_RS14265	COG2086	electron transfer activity
DSM104635_RS14270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DSM104635_RS14280	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM104635_RS14295	COG3128	pkhd-type hydroxylase
DSM104635_RS14310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104635_RS14315	COG0165	Argininosuccinate lyase
DSM104635_RS14325	COG0019	diaminopimelate decarboxylase activity
DSM104635_RS14375	COG0287	Prephenate dehydrogenase
DSM104635_RS14385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM104635_RS14410	COG1595	DNA-templated transcription, initiation
DSM104635_RS14435	COG2226	methyltransferase
DSM104635_RS14440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104635_RS14460	COG1410	methionine synthase
DSM104635_RS14460	COG0646	methionine synthase
DSM104635_RS14465	COG1410	methionine synthase
DSM104635_RS14465	COG0646	methionine synthase
DSM104635_RS14470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DSM104635_RS14480	COG2853	Lipoprotein
DSM104635_RS14490	COG0167	dihydroorotate dehydrogenase activity
DSM104635_RS14510	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DSM104635_RS14550	COG1252	NADH dehydrogenase
DSM104635_RS14555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DSM104635_RS14560	COG0083	homoserine kinase activity
DSM104635_RS14565	COG0527	aspartate kinase activity
DSM104635_RS14565	COG0460	homoserine dehydrogenase
DSM104635_RS14570	COG0626	cystathionine gamma-synthase activity
DSM104635_RS14590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DSM104635_RS14600	COG1136	(ABC) transporter
DSM104635_RS14600	COG0577	efflux transmembrane transporter activity
DSM104635_RS14605	COG1136	(ABC) transporter
DSM104635_RS14625	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS14630	COG2205	protein histidine kinase activity
DSM104635_RS14640	COG0717	Belongs to the dCTP deaminase family
DSM104635_RS14650	COG2967	ApaG domain
DSM104635_RS14660	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DSM104635_RS14665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DSM104635_RS14670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSM104635_RS14680	COG2852	Protein conserved in bacteria
DSM104635_RS14685	COG0842	Transport permease protein
DSM104635_RS14740	COG1733	regulation of RNA biosynthetic process
DSM104635_RS14780	COG2814	Major facilitator Superfamily
DSM104635_RS14795	COG4771	TonB-dependent receptor
DSM104635_RS14795	COG4771	TonB-dependent receptor
DSM104635_RS14805	COG2814	Major facilitator Superfamily
DSM104635_RS14815	COG1024	Enoyl-CoA hydratase
DSM104635_RS14840	COG1218	3'(2'),5'-bisphosphate nucleotidase
DSM104635_RS14845	COG0175	sulfate reduction
DSM104635_RS14855	COG0457	Tetratricopeptide repeat
DSM104635_RS14865	COG0596	Alpha beta hydrolase
DSM104635_RS14875	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS14885	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS14910	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS14920	COG4774	siderophore transport
DSM104635_RS14925	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DSM104635_RS14950	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS14955	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS14990	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS15000	COG0183	Belongs to the thiolase family
DSM104635_RS15015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104635_RS15020	COG1024	Enoyl-CoA hydratase
DSM104635_RS15025	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS15030	COG1024	Enoyl-CoA hydratase
DSM104635_RS15040	COG2169	Transcriptional regulator
DSM104635_RS15065	COG2186	Transcriptional regulator
DSM104635_RS15090	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104635_RS15100	COG1024	Enoyl-CoA hydratase
DSM104635_RS15105	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS15110	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS15115	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS15120	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM104635_RS15120	COG1024	Enoyl-CoA hydratase
DSM104635_RS15125	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS15130	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS15135	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS15145	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS15150	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS15155	COG1024	Enoyl-CoA hydratase
DSM104635_RS15160	COG0183	Belongs to the thiolase family
DSM104635_RS15170	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS15195	COG2188	Transcriptional regulator
DSM104635_RS15215	COG2124	cytochrome p450
DSM104635_RS15220	COG0667	Aldo Keto reductase
DSM104635_RS15235	COG1022	Amp-dependent synthetase and ligase
DSM104635_RS15235	COG3320	Male sterility
DSM104635_RS15245	COG1959	2 iron, 2 sulfur cluster binding
DSM104635_RS15265	COG0730	response to heat
DSM104635_RS15270	COG1648	precorrin-2 dehydrogenase activity
DSM104635_RS15275	COG1648	precorrin-2 dehydrogenase activity
DSM104635_RS15275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DSM104635_RS15290	COG0175	sulfate reduction
DSM104635_RS15305	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DSM104635_RS15315	COG3250	beta-galactosidase activity
DSM104635_RS15335	COG0129	dihydroxy-acid dehydratase activity
DSM104635_RS15345	COG3734	2-keto-3-deoxy-galactonokinase
DSM104635_RS15350	COG0800	Aldolase
DSM104635_RS15355	COG2186	Transcriptional regulator
DSM104635_RS15375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM104635_RS15405	COG1956	GAF domain-containing protein
DSM104635_RS15415	COG0505	Belongs to the CarA family
DSM104635_RS15420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM104635_RS15455	COG0358	DNA primase activity
DSM104635_RS15460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DSM104635_RS15510	COG1309	transcriptional regulator
DSM104635_RS15560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DSM104635_RS15565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSM104635_RS15575	COG0784	Response regulator, receiver
DSM104635_RS15580	COG0492	ferredoxin-NADP+ reductase activity
DSM104635_RS15585	COG1196	nuclear chromosome segregation
DSM104635_RS15585	COG3264	Mechanosensitive ion channel
DSM104635_RS15590	COG0583	DNA-binding transcription factor activity
DSM104635_RS15600	COG2321	neutral zinc metallopeptidase
DSM104635_RS15640	COG3268	Saccharopine dehydrogenase
DSM104635_RS15655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DSM104635_RS15660	COG0085	RNA polymerase activity
DSM104635_RS15665	COG0222	ribosome binding
DSM104635_RS15670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DSM104635_RS15710	COG1064	alcohol dehydrogenase
DSM104635_RS15720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DSM104635_RS15730	COG3920	Histidine kinase
DSM104635_RS15735	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS15740	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DSM104635_RS15740	COG0392	lysyltransferase activity
DSM104635_RS15765	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DSM104635_RS15800	COG0640	Transcriptional regulator
DSM104635_RS15815	COG0625	glutathione transferase activity
DSM104635_RS15825	COG0625	glutathione transferase activity
DSM104635_RS15835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DSM104635_RS15840	COG0049	tRNA binding
DSM104635_RS15845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DSM104635_RS15865	COG0556	nucleotide-excision repair
DSM104635_RS15915	COG4941	Belongs to the sigma-70 factor family
DSM104635_RS15920	COG3795	YCII-related domain
DSM104635_RS15930	COG1187	pseudouridine synthase activity
DSM104635_RS15940	COG0450	alkyl hydroperoxide reductase
DSM104635_RS15945	COG3453	Protein conserved in bacteria
DSM104635_RS15945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104635_RS15960	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DSM104635_RS15975	COG1278	Cold shock
DSM104635_RS15990	COG0322	excinuclease ABC activity
DSM104635_RS15995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DSM104635_RS16015	COG0037	tRNA processing
DSM104635_RS16025	COG2885	chlorophyll binding
DSM104635_RS16030	COG0823	Involved in the tonB-independent uptake of proteins
DSM104635_RS16050	COG0824	Thioesterase
DSM104635_RS16060	COG0640	Transcriptional regulator
DSM104635_RS16100	COG0667	Aldo Keto reductase
DSM104635_RS16125	COG2255	four-way junction helicase activity
DSM104635_RS16135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSM104635_RS16155	COG0632	four-way junction helicase activity
DSM104635_RS16175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DSM104635_RS16200	COG0653	protein targeting
DSM104635_RS16205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104635_RS16210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DSM104635_RS16260	COG1278	Cold shock
DSM104635_RS16285	COG0494	nUDIX hydrolase
DSM104635_RS16310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM104635_RS16345	COG0438	transferase activity, transferring glycosyl groups
DSM104635_RS16360	COG0573	inorganic phosphate transmembrane transporter activity
DSM104635_RS16365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DSM104635_RS16375	COG0019	diaminopimelate decarboxylase activity
DSM104635_RS16405	COG0534	Mate efflux family protein
DSM104635_RS16410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DSM104635_RS16415	COG1899	peptidyl-lysine modification to peptidyl-hypusine
DSM104635_RS16460	COG2226	methyltransferase
DSM104635_RS16465	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DSM104635_RS16485	COG3795	YCII-related domain
DSM104635_RS16490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DSM104635_RS16510	COG0071	Belongs to the small heat shock protein (HSP20) family
DSM104635_RS16525	COG1278	Cold shock
DSM104635_RS16535	COG0517	IMP dehydrogenase activity
DSM104635_RS16535	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DSM104635_RS16550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DSM104635_RS16560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DSM104635_RS16575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM104635_RS16575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM104635_RS16580	COG0588	phosphoglycerate mutase activity
DSM104635_RS16595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DSM104635_RS16605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM104635_RS16610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DSM104635_RS16615	COG0166	Belongs to the GPI family
DSM104635_RS16640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSM104635_RS16645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DSM104635_RS16650	COG0673	inositol 2-dehydrogenase activity
DSM104635_RS16755	COG4122	O-methyltransferase activity
DSM104635_RS16830	COG0546	phosphoglycolate phosphatase activity
DSM104635_RS16830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DSM104635_RS16835	COG0277	FAD linked oxidase domain protein
DSM104635_RS16865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM104635_RS16895	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DSM104635_RS16900	COG1091	dTDP-4-dehydrorhamnose reductase activity
DSM104635_RS16905	COG1088	dTDP-glucose 4,6-dehydratase activity
DSM104635_RS16910	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DSM104635_RS16935	COG2942	2-epimerase
DSM104635_RS16945	COG1404	Belongs to the peptidase S8 family
DSM104635_RS16955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DSM104635_RS16965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DSM104635_RS16970	COG0363	glucosamine-6-phosphate deaminase activity
DSM104635_RS16990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM104635_RS17055	COG4964	Belongs to the GSP D family
DSM104635_RS17160	COG2124	cytochrome p450
DSM104635_RS17195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM104635_RS17210	COG0436	Aminotransferase
DSM104635_RS17220	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DSM104635_RS17230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DSM104635_RS17240	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DSM104635_RS17260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DSM104635_RS17280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DSM104635_RS17285	COG0784	Response regulator, receiver
DSM104635_RS17285	COG2205	protein histidine kinase activity
DSM104635_RS17300	COG2072	flavoprotein involved in K transport
DSM104635_RS17305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DSM104635_RS17310	COG0539	negative regulation of cytoplasmic translation
DSM104635_RS17325	COG1970	mechanosensitive ion channel activity
DSM104635_RS17330	COG0135	phosphoribosylanthranilate isomerase activity
DSM104635_RS17335	COG0133	tryptophan synthase activity
DSM104635_RS17345	COG0159	tryptophan synthase activity
DSM104635_RS17350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DSM104635_RS17355	COG0285	dihydrofolate synthase activity
DSM104635_RS17370	COG2887	Belongs to the helicase family. UvrD subfamily
DSM104635_RS17375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DSM104635_RS17380	COG3178	'Phosphotransferase
DSM104635_RS17390	COG0633	Ferredoxin
DSM104635_RS17405	COG2205	protein histidine kinase activity
DSM104635_RS17410	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DSM104635_RS17415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DSM104635_RS17445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM104635_RS17455	COG2205	protein histidine kinase activity
DSM104635_RS17460	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS17490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM104635_RS17490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM104635_RS17510	COG1131	(ABC) transporter
DSM104635_RS17515	COG0667	Aldo Keto reductase
DSM104635_RS17525	COG1942	4-Oxalocrotonate Tautomerase
DSM104635_RS17595	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DSM104635_RS17600	COG1228	amidohydrolase
DSM104635_RS17615	COG0604	alcohol dehydrogenase
DSM104635_RS17615	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS17615	COG3321	synthase
DSM104635_RS17660	COG0697	spore germination
DSM104635_RS17670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DSM104635_RS17725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DSM104635_RS17740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DSM104635_RS17740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM104635_RS17745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DSM104635_RS17765	COG0138	bifunctional purine biosynthesis protein purh
DSM104635_RS17775	COG0386	Belongs to the glutathione peroxidase family
DSM104635_RS17785	COG2902	Dehydrogenase
DSM104635_RS17790	COG0628	permease
DSM104635_RS17795	COG0433	COG0433 Predicted ATPase
DSM104635_RS17805	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DSM104635_RS17820	COG2353	YceI-like domain
DSM104635_RS17860	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DSM104635_RS17875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DSM104635_RS17915	COG1309	transcriptional regulator
DSM104635_RS17925	COG1131	(ABC) transporter
DSM104635_RS17930	COG0842	Transport permease protein
DSM104635_RS17935	COG1086	Polysaccharide biosynthesis protein
DSM104635_RS17970	COG1960	acyl-CoA dehydrogenase activity
DSM104635_RS18005	COG0697	spore germination
DSM104635_RS18010	COG2050	protein possibly involved in aromatic compounds catabolism
DSM104635_RS18045	COG1396	sequence-specific DNA binding
DSM104635_RS18075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DSM104635_RS18085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DSM104635_RS18100	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS18110	COG0800	Aldolase
DSM104635_RS18115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM104635_RS18125	COG0174	glutamine synthetase
DSM104635_RS18130	COG1802	Transcriptional regulator
DSM104635_RS18140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DSM104635_RS18145	COG3842	ATPase activity
DSM104635_RS18150	COG1177	transmembrane transport
DSM104635_RS18155	COG1176	ABC-type spermidine putrescine transport system, permease component I
DSM104635_RS18170	COG0174	glutamine synthetase
DSM104635_RS18175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DSM104635_RS18210	COG3706	GGDEF domain
DSM104635_RS18230	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DSM104635_RS18235	COG2948	multi-organism process
DSM104635_RS18250	COG3451	type IV secretory pathway VirB4
DSM104635_RS18285	COG1872	DUF167
DSM104635_RS18290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DSM104635_RS18300	COG0531	amino acid
DSM104635_RS18305	COG2154	pterin-4-alpha-carbinolamine dehydratase
DSM104635_RS18310	COG2852	Protein conserved in bacteria
DSM104635_RS18320	COG1294	oxidase, subunit
DSM104635_RS18325	COG1271	oxidase subunit
DSM104635_RS18330	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS18345	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS18360	COG0284	orotidine-5'-phosphate decarboxylase activity
DSM104635_RS18375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DSM104635_RS18390	COG0181	hydroxymethylbilane synthase activity
DSM104635_RS18420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104635_RS18455	COG5425	PFAM Usg family protein
DSM104635_RS18465	COG1272	protein, Hemolysin III
DSM104635_RS18475	COG4249	Peptidase C14 caspase catalytic subunit p20
DSM104635_RS18490	COG0137	argininosuccinate synthase activity
DSM104635_RS18500	COG3158	transport of potassium into the cell
DSM104635_RS18515	COG0729	surface antigen
DSM104635_RS18525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DSM104635_RS18540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DSM104635_RS18545	COG0799	negative regulation of ribosome biogenesis
DSM104635_RS18550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DSM104635_RS18560	COG0793	Belongs to the peptidase S41A family
DSM104635_RS18570	COG0494	nUDIX hydrolase
DSM104635_RS18585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DSM104635_RS18600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DSM104635_RS18610	COG1764	response to oxidative stress
DSM104635_RS18615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DSM104635_RS18620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DSM104635_RS18625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM104635_RS18640	COG0861	Integral membrane protein TerC family
DSM104635_RS18650	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104635_RS18670	COG4974	Belongs to the 'phage' integrase family
DSM104635_RS18715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM104635_RS18745	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM104635_RS18765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DSM104635_RS18805	COG0045	succinate-CoA ligase (ADP-forming) activity
DSM104635_RS18810	COG2059	Chromate
DSM104635_RS18850	COG0039	L-malate dehydrogenase activity
DSM104635_RS18870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DSM104635_RS18875	COG1396	sequence-specific DNA binding
DSM104635_RS18880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DSM104635_RS18885	COG1253	flavin adenine dinucleotide binding
DSM104635_RS18895	COG1702	phosphate starvation-inducible protein PhoH
DSM104635_RS18900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM104635_RS18915	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DSM104635_RS18925	COG0180	Tryptophanyl-tRNA synthetase
DSM104635_RS18935	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DSM104635_RS18945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DSM104635_RS18950	COG0280	phosphate acetyltransferase
DSM104635_RS18950	COG0281	malic enzyme
DSM104635_RS18955	COG2223	nitrite transmembrane transporter activity
DSM104635_RS18965	COG0606	chelatase, subunit chli
DSM104635_RS19005	COG0792	nuclease activity
DSM104635_RS19010	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DSM104635_RS19020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DSM104635_RS19025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DSM104635_RS19035	COG3655	Transcriptional regulator
DSM104635_RS19050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DSM104635_RS19055	COG1420	regulation of RNA biosynthetic process
DSM104635_RS19060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DSM104635_RS19070	COG0667	Aldo Keto reductase
DSM104635_RS19075	COG0412	Dienelactone hydrolase
DSM104635_RS19085	COG3145	DNA-N1-methyladenine dioxygenase activity
DSM104635_RS19090	COG0443	Heat shock 70 kDa protein
DSM104635_RS19095	COG0484	heat shock protein binding
DSM104635_RS19110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DSM104635_RS19120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DSM104635_RS19135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM104635_RS19140	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DSM104635_RS19145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DSM104635_RS19150	COG5001	Diguanylate cyclase
DSM104635_RS19150	COG3300	MHYT domain
DSM104635_RS19165	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DSM104635_RS19170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DSM104635_RS19175	COG0237	dephospho-CoA kinase activity
DSM104635_RS19180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DSM104635_RS19185	COG0424	maF-like protein
DSM104635_RS19190	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DSM104635_RS19195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DSM104635_RS19200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DSM104635_RS19210	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DSM104635_RS19230	COG0584	glycerophosphoryl diester phosphodiesterase
DSM104635_RS19245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DSM104635_RS19250	COG0445	tRNA wobble uridine modification
DSM104635_RS19260	COG0357	Ribosomal RNA small subunit methyltransferase G
DSM104635_RS19265	COG1192	Involved in chromosome partitioning
DSM104635_RS19270	COG1475	DNA binding
DSM104635_RS19275	COG0436	Aminotransferase
DSM104635_RS19290	COG1301	dicarboxylic acid transport
DSM104635_RS19310	COG0495	leucyl-tRNA aminoacylation
DSM104635_RS19325	COG0352	thiamine-phosphate diphosphorylase activity
DSM104635_RS19335	COG0745	RESPONSE REGULATOR receiver
DSM104635_RS19345	COG1024	Enoyl-CoA hydratase
DSM104635_RS19350	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DSM104635_RS19400	COG0004	ammonium transporteR
DSM104635_RS19405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM104635_RS19410	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DSM104635_RS19430	COG4774	siderophore transport
DSM104635_RS19440	COG2835	tetraacyldisaccharide 4'-kinase activity
DSM104635_RS19445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM104635_RS19470	COG0681	Belongs to the peptidase S26 family
DSM104635_RS19485	COG1946	Acyl-CoA thioesterase
DSM104635_RS19500	COG2766	serine protein kinase
DSM104635_RS19505	COG2718	Belongs to the UPF0229 family
DSM104635_RS19510	COG2719	SpoVR family
DSM104635_RS19520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DSM104635_RS19540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DSM104635_RS19555	COG0779	Required for maturation of 30S ribosomal subunits
DSM104635_RS19570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DSM104635_RS19570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DSM104635_RS19580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DSM104635_RS19585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DSM104635_RS19590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DSM104635_RS19595	COG1185	polyribonucleotide nucleotidyltransferase activity
DSM104635_RS19615	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DSM104635_RS19635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM104635_RS19660	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DSM104635_RS19660	COG2885	chlorophyll binding
DSM104635_RS19675	COG0366	Alpha amylase catalytic
DSM104635_RS19680	COG3237	CsbD-like
DSM104635_RS19700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSM104635_RS19715	COG0756	dUTP diphosphatase activity
DSM104635_RS19725	COG0640	Transcriptional regulator
DSM104635_RS19735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DSM104635_RS19740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DSM104635_RS19745	COG2226	methyltransferase
DSM104635_RS19750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DSM104635_RS19765	COG1024	Enoyl-CoA hydratase
DSM104635_RS19770	COG0268	Binds directly to 16S ribosomal RNA