locus-tag	class	description
CFLA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CFLA_RS00010	COG0592	DNA-directed DNA polymerase activity
CFLA_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CFLA_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CFLA_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CFLA_RS00030	COG0187	DNA topoisomerase II activity
CFLA_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CFLA_RS00065	COG1690	Belongs to the RtcB family
CFLA_RS00070	COG1278	Cold shock
CFLA_RS00100	COG0705	Rhomboid family
CFLA_RS00115	COG3764	Sortase (surface protein transpeptidase)
CFLA_RS00130	COG0515	serine threonine protein kinase
CFLA_RS00130	COG2815	serine threonine protein kinase
CFLA_RS00140	COG0768	penicillin binding
CFLA_RS00155	COG1716	ATPase activity
CFLA_RS00190	COG1185	polyribonucleotide nucleotidyltransferase activity
CFLA_RS00245	COG3842	ATPase activity
CFLA_RS00270	COG4682	membrane
CFLA_RS00275	COG1609	Transcriptional regulator
CFLA_RS00285	COG1739	Uncharacterized protein family UPF0029
CFLA_RS00295	COG1090	epimerase
CFLA_RS00305	COG3012	SEC-C Motif Domain Protein
CFLA_RS00385	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CFLA_RS00390	COG0024	Methionine aminopeptidase
CFLA_RS00410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFLA_RS00420	COG0436	Aminotransferase
CFLA_RS00425	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CFLA_RS00470	COG2382	esterase
CFLA_RS00470	COG3693	PFAM glycoside hydrolase, family 10
CFLA_RS00475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFLA_RS00475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CFLA_RS00480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CFLA_RS00485	COG0509	glycine decarboxylation via glycine cleavage system
CFLA_RS00490	COG2197	response regulator
CFLA_RS00495	COG0494	nUDIX hydrolase
CFLA_RS00505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CFLA_RS00515	COG1136	(ABC) transporter
CFLA_RS00550	COG2818	Glycosylase
CFLA_RS00575	COG1643	Atp-dependent helicase
CFLA_RS00625	COG0420	3'-5' exonuclease activity
CFLA_RS00630	COG0419	ATPase involved in DNA repair
CFLA_RS00660	COG0531	amino acid
CFLA_RS00700	COG1780	Probably involved in ribonucleotide reductase function
CFLA_RS00705	COG2234	aminopeptidase activity
CFLA_RS00710	COG1476	TRANSCRIPTIONal
CFLA_RS00725	COG0823	Involved in the tonB-independent uptake of proteins
CFLA_RS00725	COG1506	peptidase
CFLA_RS00735	COG0717	Belongs to the dCTP deaminase family
CFLA_RS00740	COG3459	Glycosyltransferase 36 associated
CFLA_RS00775	COG3177	Filamentation induced by cAMP protein fic
CFLA_RS00805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFLA_RS00810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFLA_RS00815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFLA_RS00820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CFLA_RS00915	COG1609	Transcriptional regulator
CFLA_RS00925	COG2084	Dehydrogenase
CFLA_RS00930	COG2376	Dihydroxyacetone kinase
CFLA_RS00935	COG0698	ribose 5-phosphate isomerase
CFLA_RS00945	COG1132	(ABC) transporter
CFLA_RS00950	COG1846	Transcriptional regulator
CFLA_RS00970	COG1988	membrane-bound metal-dependent
CFLA_RS00980	COG1595	DNA-templated transcription, initiation
CFLA_RS00995	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CFLA_RS01030	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFLA_RS01030	COG0456	acetyltransferase
CFLA_RS01045	COG0247	lactate metabolic process
CFLA_RS01045	COG2181	nitrate reductase activity
CFLA_RS01050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFLA_RS01050	COG2111	Na H antiporter
CFLA_RS01055	COG1006	Multisubunit Na H antiporter MnhC subunit
CFLA_RS01060	COG0651	ATP synthesis coupled electron transport
CFLA_RS01110	COG3842	ATPase activity
CFLA_RS01135	COG4941	Belongs to the sigma-70 factor family
CFLA_RS01140	COG3795	YCII-related domain
CFLA_RS01145	COG3795	YCII-related domain
CFLA_RS01150	COG0693	protein deglycase activity
CFLA_RS01175	COG2318	DinB family
CFLA_RS01190	COG3300	MHYT domain
CFLA_RS01190	COG5001	Diguanylate cyclase
CFLA_RS01195	COG1028	Short-chain dehydrogenase reductase Sdr
CFLA_RS01210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFLA_RS01215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFLA_RS01225	COG2808	Putative FMN-binding domain
CFLA_RS01265	COG3559	Exporter of polyketide antibiotics
CFLA_RS01270	COG1131	(ABC) transporter
CFLA_RS01285	COG0346	lactoylglutathione lyase activity
CFLA_RS01325	COG1309	transcriptional regulator
CFLA_RS01405	COG4585	Histidine kinase
CFLA_RS01425	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFLA_RS01440	COG0671	phosphoesterase, PA-phosphatase related
CFLA_RS01445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFLA_RS01445	COG1116	anion transmembrane transporter activity
CFLA_RS01455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFLA_RS01470	COG0318	PFAM AMP-dependent synthetase and ligase
CFLA_RS01475	COG0183	Belongs to the thiolase family
CFLA_RS01485	COG1028	Short-chain dehydrogenase reductase Sdr
CFLA_RS01495	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFLA_RS01535	COG0667	Aldo Keto reductase
CFLA_RS01580	COG1278	Cold shock
CFLA_RS01590	COG0110	maltose O-acetyltransferase activity
CFLA_RS01610	COG0406	alpha-ribazole phosphatase activity
CFLA_RS01620	COG1522	sequence-specific DNA binding
CFLA_RS01650	COG2267	carboxylic ester hydrolase activity
CFLA_RS01665	COG2207	Transcriptional regulator
CFLA_RS01665	COG3708	Transcriptional regulator
CFLA_RS01695	COG1309	transcriptional regulator
CFLA_RS01700	COG2226	methyltransferase
CFLA_RS01705	COG3655	Transcriptional regulator
CFLA_RS01725	COG3501	Rhs element vgr protein
CFLA_RS01725	COG3409	Peptidoglycan-binding domain 1 protein
CFLA_RS01785	COG2205	protein histidine kinase activity
CFLA_RS01825	COG2217	Heavy metal translocating P-type atpase
CFLA_RS01835	COG1937	Protein conserved in bacteria
CFLA_RS01840	COG0446	pyridine nucleotide-disulphide oxidoreductase
CFLA_RS01875	COG1733	regulation of RNA biosynthetic process
CFLA_RS01895	COG3387	PFAM Glycoside hydrolase 15-related
CFLA_RS01905	COG0463	Glycosyl transferase, family 2
CFLA_RS01915	COG4978	Transcriptional regulator
CFLA_RS01915	COG0789	Transcriptional regulator
CFLA_RS01935	COG0640	Transcriptional regulator
CFLA_RS01945	COG1247	-acetyltransferase
CFLA_RS01950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFLA_RS01955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFLA_RS01960	COG0798	PFAM Bile acid sodium symporter
CFLA_RS01990	COG1595	DNA-templated transcription, initiation
CFLA_RS01995	COG2146	nitrite reductase [NAD(P)H] activity
CFLA_RS02000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFLA_RS02005	COG0243	molybdopterin cofactor binding
CFLA_RS02030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFLA_RS02120	COG0789	Transcriptional regulator
CFLA_RS02155	COG1522	sequence-specific DNA binding
CFLA_RS02175	COG0572	uridine kinase
CFLA_RS02210	COG2826	transposase and inactivated derivatives, IS30 family
CFLA_RS02215	COG0443	Heat shock 70 kDa protein
CFLA_RS02220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CFLA_RS02225	COG0484	heat shock protein binding
CFLA_RS02230	COG0789	Transcriptional regulator
CFLA_RS02235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFLA_RS02250	COG1780	Probably involved in ribonucleotide reductase function
CFLA_RS02255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFLA_RS02290	COG3507	Belongs to the glycosyl hydrolase 43 family
CFLA_RS02295	COG3345	alpha-galactosidase
CFLA_RS02310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFLA_RS02310	COG0574	Belongs to the PEP-utilizing enzyme family
CFLA_RS02325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CFLA_RS02360	COG0640	Transcriptional regulator
CFLA_RS02365	COG0659	secondary active sulfate transmembrane transporter activity
CFLA_RS02375	COG1595	DNA-templated transcription, initiation
CFLA_RS02390	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CFLA_RS02420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CFLA_RS02460	COG3973	AAA domain
CFLA_RS02480	COG2022	thiamine diphosphate biosynthetic process
CFLA_RS02490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFLA_RS02490	COG2022	thiamine diphosphate biosynthetic process
CFLA_RS02495	COG0352	thiamine-phosphate diphosphorylase activity
CFLA_RS02505	COG0187	DNA topoisomerase II activity
CFLA_RS02510	COG0395	ABC-type sugar transport system, permease component
CFLA_RS02515	COG1175	transmembrane transport
CFLA_RS02520	COG1653	transport
CFLA_RS02530	COG0596	Alpha beta hydrolase
CFLA_RS02550	COG2226	methyltransferase
CFLA_RS02585	COG0494	nUDIX hydrolase
CFLA_RS02625	COG5183	chlorophyll binding
CFLA_RS02625	COG2133	pyrroloquinoline quinone binding
CFLA_RS02670	COG2755	lipolytic protein G-D-S-L family
CFLA_RS02670	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CFLA_RS02675	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFLA_RS02715	COG0058	SHG alpha-glucan phosphorylase activity
CFLA_RS02735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CFLA_RS02820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CFLA_RS02825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFLA_RS02830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CFLA_RS02840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CFLA_RS02845	COG1194	a g-specific adenine glycosylase
CFLA_RS02855	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CFLA_RS02860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CFLA_RS02875	COG0745	RESPONSE REGULATOR receiver
CFLA_RS02885	COG1754	DNA topoisomerase type I activity
CFLA_RS02885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFLA_RS02900	COG0673	inositol 2-dehydrogenase activity
CFLA_RS02905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CFLA_RS02910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CFLA_RS02955	COG1793	dna ligase
CFLA_RS02955	COG3285	dna ligase
CFLA_RS02985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CFLA_RS03000	COG1404	Belongs to the peptidase S8 family
CFLA_RS03015	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CFLA_RS03015	COG1672	PFAM Archaeal ATPase
CFLA_RS03040	COG0277	FAD linked oxidase domain protein
CFLA_RS03040	COG0247	lactate metabolic process
CFLA_RS03070	COG0604	alcohol dehydrogenase
CFLA_RS03080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CFLA_RS03085	COG2873	o-acetylhomoserine
CFLA_RS03100	COG3883	PFAM NLP P60 protein
CFLA_RS03100	COG0791	NLP P60 protein
CFLA_RS03125	COG3654	unkown
CFLA_RS03135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CFLA_RS03140	COG2027	D-alanyl-D-alanine carboxypeptidase
CFLA_RS03150	COG0037	tRNA processing
CFLA_RS03160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFLA_RS03165	COG0302	gtp cyclohydrolase
CFLA_RS03170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CFLA_RS03175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CFLA_RS03200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CFLA_RS03210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CFLA_RS03230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CFLA_RS03240	COG1070	Carbohydrate kinase
CFLA_RS03245	COG2115	Belongs to the xylose isomerase family
CFLA_RS03255	COG2706	6-phosphogluconolactonase activity
CFLA_RS03260	COG2197	response regulator
CFLA_RS03285	COG0438	transferase activity, transferring glycosyl groups
CFLA_RS03290	COG0588	phosphoglycerate mutase activity
CFLA_RS03300	COG5002	protein histidine kinase activity
CFLA_RS03305	COG0745	RESPONSE REGULATOR receiver
CFLA_RS03320	COG0581	inorganic phosphate transmembrane transporter activity
CFLA_RS03325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CFLA_RS03340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CFLA_RS03345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CFLA_RS03355	COG1063	alcohol dehydrogenase
CFLA_RS03365	COG3226	Transcriptional regulator
CFLA_RS03375	COG0215	cysteine-tRNA ligase activity
CFLA_RS03380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFLA_RS03390	COG3842	ATPase activity
CFLA_RS03445	COG4585	Histidine kinase
CFLA_RS03460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CFLA_RS03480	COG0459	protein refolding
CFLA_RS03510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CFLA_RS03530	COG0831	urea catabolic process
CFLA_RS03575	COG0733	neurotransmitter:sodium symporter activity
CFLA_RS03610	COG2205	protein histidine kinase activity
CFLA_RS03615	COG0745	RESPONSE REGULATOR receiver
CFLA_RS03625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFLA_RS03655	COG1061	Type III restriction enzyme res subunit
CFLA_RS03670	COG1473	amidohydrolase
CFLA_RS03675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFLA_RS03725	COG0463	Glycosyl transferase, family 2
CFLA_RS03750	COG2244	polysaccharide biosynthetic process
CFLA_RS03755	COG0438	transferase activity, transferring glycosyl groups
CFLA_RS03770	COG1278	Cold shock
CFLA_RS03795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFLA_RS03815	COG2826	transposase and inactivated derivatives, IS30 family
CFLA_RS03820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CFLA_RS03840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFLA_RS03865	COG2814	Major facilitator Superfamily
CFLA_RS03890	COG3103	Sh3 type 3 domain protein
CFLA_RS03890	COG1388	LysM domain
CFLA_RS03890	COG0791	NLP P60 protein
CFLA_RS03910	COG1522	sequence-specific DNA binding
CFLA_RS03920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFLA_RS03925	COG1834	amidinotransferase
CFLA_RS03935	COG0667	Aldo Keto reductase
CFLA_RS03950	COG2610	gluconate transmembrane transporter activity
CFLA_RS03955	COG3265	gluconokinase activity
CFLA_RS04025	COG2319	Wd-40 repeat
CFLA_RS04025	COG5635	Nacht domain
CFLA_RS04035	COG2801	Transposase and inactivated derivatives
CFLA_RS04040	COG2801	Transposase and inactivated derivatives
CFLA_RS04075	COG3693	PFAM glycoside hydrolase, family 10
CFLA_RS04080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFLA_RS04095	COG4941	Belongs to the sigma-70 factor family
CFLA_RS04100	COG3795	YCII-related domain
CFLA_RS04115	COG1295	ribonuclease BN
CFLA_RS04120	COG1609	Transcriptional regulator
CFLA_RS04130	COG4585	Histidine kinase
CFLA_RS04135	COG2197	response regulator
CFLA_RS04140	COG4585	Histidine kinase
CFLA_RS04150	COG1266	CAAX protease self-immunity
CFLA_RS04180	COG1970	mechanosensitive ion channel activity
CFLA_RS04200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CFLA_RS04230	COG2261	transglycosylase associated protein
CFLA_RS04270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFLA_RS04275	COG0084	hydrolase, TatD family'
CFLA_RS04290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CFLA_RS04295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CFLA_RS04305	COG2197	response regulator
CFLA_RS04310	COG4152	abc transporter atp-binding protein
CFLA_RS04325	COG0745	RESPONSE REGULATOR receiver
CFLA_RS04330	COG2205	protein histidine kinase activity
CFLA_RS04345	COG0488	(ABC) transporter
CFLA_RS04350	COG0640	Transcriptional regulator
CFLA_RS04355	COG2807	transmembrane transport
CFLA_RS04380	COG1309	transcriptional regulator
CFLA_RS04405	COG3265	gluconokinase activity
CFLA_RS04410	COG4948	Mandelate Racemase Muconate Lactonizing
CFLA_RS04415	COG1904	glucuronate isomerase
CFLA_RS04420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CFLA_RS04435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CFLA_RS04440	COG0193	aminoacyl-tRNA hydrolase activity
CFLA_RS04445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFLA_RS04450	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CFLA_RS04450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CFLA_RS04505	COG0489	protein tyrosine kinase activity
CFLA_RS04515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CFLA_RS04535	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CFLA_RS04540	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CFLA_RS04550	COG2890	protein-(glutamine-N5) methyltransferase activity
CFLA_RS04555	COG0148	phosphopyruvate hydratase activity
CFLA_RS04595	COG1253	flavin adenine dinucleotide binding
CFLA_RS04600	COG1252	NADH dehydrogenase
CFLA_RS04620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CFLA_RS04630	COG1131	(ABC) transporter
CFLA_RS04650	COG3458	cephalosporin-C deacetylase activity
CFLA_RS04685	COG1793	dna ligase
CFLA_RS04700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFLA_RS04715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CFLA_RS04720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFLA_RS04730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CFLA_RS04740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFLA_RS04750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFLA_RS04755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CFLA_RS04760	COG2133	pyrroloquinoline quinone binding
CFLA_RS04760	COG5183	chlorophyll binding
CFLA_RS04810	COG0577	efflux transmembrane transporter activity
CFLA_RS04810	COG1136	(ABC) transporter
CFLA_RS04830	COG0114	fumarate hydratase activity
CFLA_RS04860	COG0288	reversible hydration of carbon dioxide
CFLA_RS04870	COG1722	exodeoxyribonuclease VII activity
CFLA_RS04875	COG1570	exodeoxyribonuclease VII activity
CFLA_RS04880	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CFLA_RS04890	COG1322	Protein conserved in bacteria
CFLA_RS04920	COG0012	GTP binding
CFLA_RS04930	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CFLA_RS04935	COG2154	pterin-4-alpha-carbinolamine dehydratase
CFLA_RS04940	COG0747	negative chemotaxis
CFLA_RS04950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFLA_RS04970	COG1217	gtp-binding protein TYPA
CFLA_RS04975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CFLA_RS05025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFLA_RS05030	COG0535	radical SAM domain protein
CFLA_RS05035	COG1611	Belongs to the LOG family
CFLA_RS05040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CFLA_RS05055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CFLA_RS05060	COG4122	O-methyltransferase activity
CFLA_RS05065	COG1595	DNA-templated transcription, initiation
CFLA_RS05075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFLA_RS05080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFLA_RS05105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFLA_RS05110	COG1053	succinate dehydrogenase
CFLA_RS05120	COG2009	succinate dehydrogenase
CFLA_RS05125	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CFLA_RS05125	COG0662	Cupin 2, conserved barrel domain protein
CFLA_RS05130	COG1473	amidohydrolase
CFLA_RS05130	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CFLA_RS05135	COG1744	ABC transporter substrate-binding protein PnrA-like
CFLA_RS05140	COG3845	ABC transporter
CFLA_RS05145	COG4603	Belongs to the binding-protein-dependent transport system permease family
CFLA_RS05150	COG1079	Belongs to the binding-protein-dependent transport system permease family
CFLA_RS05170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CFLA_RS05185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFLA_RS05205	COG4770	biotin carboxylase activity
CFLA_RS05210	COG0424	maF-like protein
CFLA_RS05220	COG2182	Extracellular solute-binding protein
CFLA_RS05240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CFLA_RS05255	COG2135	peptidase activity
CFLA_RS05280	COG1454	alcohol dehydrogenase
CFLA_RS05280	COG1012	belongs to the aldehyde dehydrogenase family
CFLA_RS05295	COG2186	Transcriptional regulator
CFLA_RS05300	COG0018	arginyl-trna synthetase
CFLA_RS05305	COG0019	diaminopimelate decarboxylase activity
CFLA_RS05315	COG0460	homoserine dehydrogenase
CFLA_RS05320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CFLA_RS05325	COG0083	homoserine kinase activity
CFLA_RS05340	COG0254	rRNA binding
CFLA_RS05345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CFLA_RS05350	COG2890	protein-(glutamine-N5) methyltransferase activity
CFLA_RS05360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFLA_RS05370	COG0356	it plays a direct role in the translocation of protons across the membrane
CFLA_RS05375	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFLA_RS05380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CFLA_RS05385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFLA_RS05390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CFLA_RS05395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CFLA_RS05400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CFLA_RS05405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CFLA_RS05415	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CFLA_RS05455	COG1609	Transcriptional regulator
CFLA_RS05520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CFLA_RS05530	COG3281	Trehalose synthase
CFLA_RS05540	COG0366	Alpha amylase catalytic
CFLA_RS05565	COG2086	electron transfer activity
CFLA_RS05570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CFLA_RS05585	COG0482	sulfurtransferase activity
CFLA_RS05620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CFLA_RS05630	COG0456	acetyltransferase
CFLA_RS05645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFLA_RS05650	COG0154	amidase activity
CFLA_RS05655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFLA_RS05660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFLA_RS05685	COG1609	Transcriptional regulator
CFLA_RS05695	COG1175	transmembrane transport
CFLA_RS05700	COG0395	ABC-type sugar transport system, permease component
CFLA_RS05705	COG1472	Belongs to the glycosyl hydrolase 3 family
CFLA_RS05710	COG0129	dihydroxy-acid dehydratase activity
CFLA_RS05730	COG0129	dihydroxy-acid dehydratase activity
CFLA_RS05805	COG0714	Associated with various cellular activities
CFLA_RS05820	COG2815	serine threonine protein kinase
CFLA_RS05820	COG0515	serine threonine protein kinase
CFLA_RS05830	COG0366	Alpha amylase catalytic
CFLA_RS05840	COG1131	(ABC) transporter
CFLA_RS05850	COG0644	oxidoreductase
CFLA_RS05885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CFLA_RS05895	COG0473	3-isopropylmalate dehydrogenase activity
CFLA_RS05900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFLA_RS05910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFLA_RS05920	COG0095	Lipoate-protein ligase
CFLA_RS05935	COG1136	(ABC) transporter
CFLA_RS05955	COG1678	Uncharacterized ACR, COG1678
CFLA_RS05960	COG3304	Inner membrane component domain
CFLA_RS05965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CFLA_RS05985	COG0318	PFAM AMP-dependent synthetase and ligase
CFLA_RS06000	COG0328	RNA-DNA hybrid ribonuclease activity
CFLA_RS06015	COG0673	inositol 2-dehydrogenase activity
CFLA_RS06040	COG0259	pyridoxamine-phosphate oxidase activity
CFLA_RS06060	COG1115	amino acid carrier protein
CFLA_RS06065	COG2357	RelA SpoT domain protein
CFLA_RS06070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFLA_RS06085	COG0483	inositol monophosphate 1-phosphatase activity
CFLA_RS06105	COG1595	DNA-templated transcription, initiation
CFLA_RS06150	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFLA_RS06150	COG0567	Dehydrogenase, E1 component
CFLA_RS06155	COG2205	protein histidine kinase activity
CFLA_RS06160	COG0745	RESPONSE REGULATOR receiver
CFLA_RS06165	COG1253	flavin adenine dinucleotide binding
CFLA_RS06220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CFLA_RS06260	COG0589	response to stress
CFLA_RS06265	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CFLA_RS06270	COG2884	Cell division ATP-binding protein ftsE
CFLA_RS06275	COG2177	Part of the ABC transporter FtsEX involved in
CFLA_RS06285	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CFLA_RS06295	COG0514	ATP-dependent DNA helicase (RecQ)
CFLA_RS06310	COG1793	dna ligase
CFLA_RS06400	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFLA_RS06405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFLA_RS06410	COG1215	transferase activity, transferring glycosyl groups
CFLA_RS06415	COG5002	protein histidine kinase activity
CFLA_RS06430	COG0714	Associated with various cellular activities
CFLA_RS06440	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CFLA_RS06470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFLA_RS06475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFLA_RS06480	COG2267	carboxylic ester hydrolase activity
CFLA_RS06515	COG0745	RESPONSE REGULATOR receiver
CFLA_RS06520	COG2205	protein histidine kinase activity
CFLA_RS06535	COG2814	Major facilitator Superfamily
CFLA_RS06540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CFLA_RS06545	COG1854	S-ribosylhomocysteine lyase activity
CFLA_RS06550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CFLA_RS06600	COG0166	Belongs to the GPI family
CFLA_RS06615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFLA_RS06620	COG1725	Transcriptional regulator
CFLA_RS06645	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CFLA_RS06655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CFLA_RS06665	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CFLA_RS06670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CFLA_RS06675	COG0488	(ABC) transporter
CFLA_RS06690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFLA_RS06715	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CFLA_RS06730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFLA_RS06740	COG1174	glycine betaine transport
CFLA_RS06745	COG1174	glycine betaine transport
CFLA_RS06765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CFLA_RS06790	COG1335	isochorismatase
CFLA_RS06800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CFLA_RS06835	COG0702	epimerase
CFLA_RS06845	COG1946	Acyl-CoA thioesterase
CFLA_RS06855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFLA_RS06860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFLA_RS06865	COG2190	(PTS) system
CFLA_RS06865	COG1263	PTS System
CFLA_RS06865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CFLA_RS06870	COG0668	transmembrane transport
CFLA_RS06875	COG1505	serine-type exopeptidase activity
CFLA_RS06915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CFLA_RS06925	COG3590	peptidase
CFLA_RS06930	COG0698	ribose 5-phosphate isomerase
CFLA_RS06935	COG4552	Acetyltransferase involved in intracellular survival and related
CFLA_RS06950	COG1832	CoA-binding protein
CFLA_RS06960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFLA_RS06965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFLA_RS06975	COG1116	anion transmembrane transporter activity
CFLA_RS06985	COG2755	lipolytic protein G-D-S-L family
CFLA_RS06985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CFLA_RS06990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFLA_RS07005	COG1045	serine acetyltransferase
CFLA_RS07030	COG0544	peptidyl-prolyl cis-trans isomerase activity
CFLA_RS07035	COG0740	serine-type endopeptidase activity
CFLA_RS07040	COG0740	serine-type endopeptidase activity
CFLA_RS07045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CFLA_RS07050	COG0287	Prephenate dehydrogenase
CFLA_RS07050	COG1605	Chorismate mutase
CFLA_RS07075	COG0765	amino acid transport
CFLA_RS07085	COG0525	valine-tRNA ligase activity
CFLA_RS07115	COG1476	TRANSCRIPTIONal
CFLA_RS07120	COG1063	alcohol dehydrogenase
CFLA_RS07130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFLA_RS07135	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CFLA_RS07135	COG0778	Nitroreductase
CFLA_RS07160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFLA_RS07165	COG1674	ftsk spoiiie
CFLA_RS07205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFLA_RS07230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFLA_RS07235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFLA_RS07240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFLA_RS07250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFLA_RS07255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFLA_RS07260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFLA_RS07275	COG1132	(ABC) transporter
CFLA_RS07320	COG1619	proteins homologs of microcin C7 resistance protein MccF
CFLA_RS07330	COG0546	phosphoglycolate phosphatase activity
CFLA_RS07350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CFLA_RS07355	COG0285	dihydrofolate synthase activity
CFLA_RS07360	COG2376	Dihydroxyacetone kinase
CFLA_RS07365	COG1461	Dihydroxyacetone kinase
CFLA_RS07385	COG1196	nuclear chromosome segregation
CFLA_RS07410	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CFLA_RS07425	COG0228	four-way junction DNA binding
CFLA_RS07430	COG1837	Belongs to the UPF0109 family
CFLA_RS07435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CFLA_RS07440	COG0336	Belongs to the RNA methyltransferase TrmD family
CFLA_RS07445	COG0335	large ribosomal subunit rRNA binding
CFLA_RS07450	COG0681	Belongs to the peptidase S26 family
CFLA_RS07455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CFLA_RS07465	COG0792	nuclease activity
CFLA_RS07480	COG4974	Belongs to the 'phage' integrase family
CFLA_RS07485	COG1191	sigma factor activity
CFLA_RS07490	COG4942	peptidase
CFLA_RS07495	COG0052	Belongs to the universal ribosomal protein uS2 family
CFLA_RS07500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CFLA_RS07510	COG0233	cytoplasmic translational termination
CFLA_RS07515	COG0575	Belongs to the CDS family
CFLA_RS07520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CFLA_RS07530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CFLA_RS07535	COG0723	plastoquinol--plastocyanin reductase activity
CFLA_RS07535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFLA_RS07540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFLA_RS07560	COG3842	ATPase activity
CFLA_RS07565	COG1176	ABC-type spermidine putrescine transport system, permease component I
CFLA_RS07570	COG1177	transmembrane transport
CFLA_RS07575	COG0750	zinc metalloprotease
CFLA_RS07580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CFLA_RS07595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFLA_RS07600	COG0442	prolyl-tRNA aminoacylation
CFLA_RS07610	COG0779	Required for maturation of 30S ribosomal subunits
CFLA_RS07625	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CFLA_RS07630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CFLA_RS07640	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CFLA_RS07645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CFLA_RS07650	COG5297	Belongs to the glycosyl hydrolase family 6
CFLA_RS07650	COG3250	beta-galactosidase activity
CFLA_RS07660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CFLA_RS07665	COG1185	polyribonucleotide nucleotidyltransferase activity
CFLA_RS07670	COG0612	Peptidase, M16
CFLA_RS07680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CFLA_RS07710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CFLA_RS07720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFLA_RS07725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CFLA_RS07730	COG4977	sequence-specific DNA binding
CFLA_RS07745	COG1674	ftsk spoiiie
CFLA_RS07765	COG1058	Belongs to the CinA family
CFLA_RS07765	COG1546	Belongs to the CinA family
CFLA_RS07770	COG1396	sequence-specific DNA binding
CFLA_RS07775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFLA_RS07780	COG1201	RNA secondary structure unwinding
CFLA_RS07800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CFLA_RS07805	COG2137	regulation of response to DNA damage stimulus
CFLA_RS07810	COG1418	mRNA catabolic process
CFLA_RS07815	COG0765	amino acid transport
CFLA_RS07820	COG0765	amino acid transport
CFLA_RS07825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFLA_RS07830	COG1126	abc transporter atp-binding protein
CFLA_RS07835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFLA_RS07840	COG2985	domain, Protein
CFLA_RS07840	COG0569	domain protein
CFLA_RS07865	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CFLA_RS07880	COG2813	Specifically methylates the guanine in position
CFLA_RS07885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CFLA_RS07905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CFLA_RS07915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CFLA_RS07925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFLA_RS07955	COG4251	negative regulation of phosphorylation
CFLA_RS07960	COG0784	Response regulator, receiver
CFLA_RS07970	COG1278	Cold shock
CFLA_RS08000	COG0714	Associated with various cellular activities
CFLA_RS08005	COG2001	Belongs to the MraZ family
CFLA_RS08010	COG0275	rRNA processing
CFLA_RS08020	COG0768	penicillin binding
CFLA_RS08025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFLA_RS08030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CFLA_RS08035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFLA_RS08040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CFLA_RS08050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CFLA_RS08060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CFLA_RS08065	COG1496	oxidoreductase activity
CFLA_RS08070	COG1799	cell septum assembly
CFLA_RS08080	COG3599	regulation of cell shape
CFLA_RS08090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CFLA_RS08100	COG0587	DNA-directed DNA polymerase activity
CFLA_RS08125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CFLA_RS08135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFLA_RS08140	COG0131	Imidazoleglycerol-phosphate dehydratase
CFLA_RS08155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CFLA_RS08195	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CFLA_RS08200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CFLA_RS08205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CFLA_RS08220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CFLA_RS08240	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CFLA_RS08245	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CFLA_RS08250	COG0352	thiamine-phosphate diphosphorylase activity
CFLA_RS08255	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CFLA_RS08255	COG0351	phosphomethylpyrimidine kinase
CFLA_RS08255	COG0352	thiamine-phosphate diphosphorylase activity
CFLA_RS08280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CFLA_RS08285	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CFLA_RS08290	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CFLA_RS08305	COG1438	arginine binding
CFLA_RS08310	COG0137	argininosuccinate synthase activity
CFLA_RS08315	COG0165	Argininosuccinate lyase
CFLA_RS08330	COG2094	Belongs to the DNA glycosylase MPG family
CFLA_RS08335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFLA_RS08380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CFLA_RS08385	COG0497	DNA recombination
CFLA_RS08410	COG0504	CTP synthase activity
CFLA_RS08415	COG0494	nUDIX hydrolase
CFLA_RS08450	COG0719	Fe-S assembly protein
CFLA_RS08460	COG0396	ATPase activity
CFLA_RS08470	COG0822	iron-sulfur transferase activity
CFLA_RS08475	COG2151	metal-sulfur cluster biosynthetic enzyme
CFLA_RS08490	COG1122	ATPase activity
CFLA_RS08495	COG1268	BioY protein
CFLA_RS08500	COG0488	(ABC) transporter
CFLA_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
CFLA_RS08545	COG0297	glycogen (starch) synthase activity
CFLA_RS08555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CFLA_RS08575	COG1435	thymidine kinase activity
CFLA_RS08585	COG2860	membrane
CFLA_RS08605	COG0756	dUTP diphosphatase activity
CFLA_RS08630	COG0569	domain protein
CFLA_RS08635	COG0531	amino acid
CFLA_RS08640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFLA_RS08650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CFLA_RS08675	COG0519	Catalyzes the synthesis of GMP from XMP
CFLA_RS08675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFLA_RS08700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CFLA_RS08710	COG1024	Enoyl-CoA hydratase
CFLA_RS08710	COG1250	3-hydroxyacyl-CoA dehydrogenase
CFLA_RS08715	COG0183	Belongs to the thiolase family
CFLA_RS08720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CFLA_RS08725	COG2197	response regulator
CFLA_RS08735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CFLA_RS08760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CFLA_RS08760	COG1648	precorrin-2 dehydrogenase activity
CFLA_RS08775	COG0175	sulfate reduction
CFLA_RS08780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFLA_RS08805	COG1305	Transglutaminase-like
CFLA_RS08810	COG0463	Glycosyl transferase, family 2
CFLA_RS08850	COG0314	molybdopterin synthase activity
CFLA_RS08870	COG0315	cyclic pyranopterin monophosphate synthase activity
CFLA_RS08875	COG0315	cyclic pyranopterin monophosphate synthase activity
CFLA_RS08875	COG0521	Mo-molybdopterin cofactor biosynthetic process
CFLA_RS08895	COG1140	nitrate reductase beta subunit
CFLA_RS08930	COG2223	nitrite transmembrane transporter activity
CFLA_RS08935	COG0243	molybdopterin cofactor binding
CFLA_RS08945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFLA_RS08955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CFLA_RS08955	COG1648	precorrin-2 dehydrogenase activity
CFLA_RS08970	COG1216	Glycosyl transferase, family 2
CFLA_RS08995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFLA_RS08995	COG0512	Glutamine amidotransferase of anthranilate synthase
CFLA_RS09000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFLA_RS09020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFLA_RS09030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CFLA_RS09035	COG1560	Kdo2-lipid A biosynthetic process
CFLA_RS09050	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CFLA_RS09055	COG1051	belongs to the nudix hydrolase family
CFLA_RS09065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CFLA_RS09070	COG0217	transcriptional regulatory protein
CFLA_RS09080	COG0632	four-way junction helicase activity
CFLA_RS09085	COG2255	four-way junction helicase activity
CFLA_RS09095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFLA_RS09100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFLA_RS09105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFLA_RS09110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CFLA_RS09120	COG1196	nuclear chromosome segregation
CFLA_RS09130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFLA_RS09135	COG0124	histidyl-tRNA synthetase
CFLA_RS09150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CFLA_RS09170	COG2409	Drug exporters of the RND superfamily
CFLA_RS09180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CFLA_RS09200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CFLA_RS09205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CFLA_RS09215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CFLA_RS09220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CFLA_RS09230	COG1459	type II secretion system
CFLA_RS09235	COG4968	Prepilin-type N-terminal cleavage methylation domain
CFLA_RS09255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CFLA_RS09275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CFLA_RS09280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CFLA_RS09285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CFLA_RS09305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CFLA_RS09310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFLA_RS09315	COG5001	Diguanylate cyclase
CFLA_RS09320	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CFLA_RS09325	COG0540	Belongs to the ATCase OTCase family
CFLA_RS09330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFLA_RS09340	COG0505	Belongs to the CarA family
CFLA_RS09345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFLA_RS09350	COG0284	orotidine-5'-phosphate decarboxylase activity
CFLA_RS09365	COG0194	GDP metabolic process
CFLA_RS09370	COG1758	RNA polymerase activity
CFLA_RS09380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CFLA_RS09390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CFLA_RS09400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CFLA_RS09415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFLA_RS09415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFLA_RS09420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CFLA_RS09425	COG0140	phosphoribosyl-ATP diphosphatase activity
CFLA_RS09430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CFLA_RS09460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFLA_RS09465	COG0805	protein transport
CFLA_RS09475	COG4581	dead DEAH box helicase
CFLA_RS09480	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CFLA_RS09495	COG0667	Aldo Keto reductase
CFLA_RS09510	COG0456	acetyltransferase
CFLA_RS09525	COG1192	Involved in chromosome partitioning
CFLA_RS09545	COG1716	ATPase activity
CFLA_RS09580	COG1609	Transcriptional regulator
CFLA_RS09590	COG5297	Belongs to the glycosyl hydrolase family 6
CFLA_RS09615	COG1796	DNA polymerase
CFLA_RS09615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFLA_RS09620	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CFLA_RS09630	COG0783	Belongs to the Dps family
CFLA_RS09650	COG0579	oxidoreductase
CFLA_RS09665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFLA_RS09690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFLA_RS09695	COG1053	succinate dehydrogenase
CFLA_RS09710	COG0589	response to stress
CFLA_RS09745	COG1160	GTP binding
CFLA_RS09755	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CFLA_RS09770	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CFLA_RS09775	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CFLA_RS09790	COG0109	protoheme IX farnesyltransferase activity
CFLA_RS09800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CFLA_RS09815	COG0363	glucosamine-6-phosphate deaminase activity
CFLA_RS09825	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFLA_RS09830	COG0149	triose-phosphate isomerase activity
CFLA_RS09835	COG0126	phosphoglycerate kinase activity
CFLA_RS09840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CFLA_RS09845	COG1481	regulation of sporulation
CFLA_RS09855	COG1660	Displays ATPase and GTPase activities
CFLA_RS09860	COG0322	excinuclease ABC activity
CFLA_RS09875	COG3387	PFAM Glycoside hydrolase 15-related
CFLA_RS09880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFLA_RS09905	COG0556	nucleotide-excision repair
CFLA_RS09915	COG0237	dephospho-CoA kinase activity
CFLA_RS09915	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CFLA_RS09920	COG0539	negative regulation of cytoplasmic translation
CFLA_RS09935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFLA_RS09940	COG0601	transmembrane transport
CFLA_RS09945	COG0747	negative chemotaxis
CFLA_RS09950	COG2226	methyltransferase
CFLA_RS09955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFLA_RS09970	COG2050	protein possibly involved in aromatic compounds catabolism
CFLA_RS10000	COG0683	leucine binding
CFLA_RS10035	COG0070	glutamate synthase
CFLA_RS10035	COG0067	glutamate synthase
CFLA_RS10035	COG0069	glutamate synthase activity
CFLA_RS10040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CFLA_RS10045	COG0159	tryptophan synthase activity
CFLA_RS10050	COG0133	tryptophan synthase activity
CFLA_RS10055	COG0134	indole-3-glycerol-phosphate synthase activity
CFLA_RS10095	COG1132	(ABC) transporter
CFLA_RS10100	COG1132	(ABC) transporter
CFLA_RS10110	COG0107	imidazoleglycerol-phosphate synthase activity
CFLA_RS10120	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CFLA_RS10125	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CFLA_RS10130	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CFLA_RS10140	COG4122	O-methyltransferase activity
CFLA_RS10145	COG1222	aaa ATPase
CFLA_RS10155	COG0517	IMP dehydrogenase activity
CFLA_RS10155	COG1994	Peptidase M50
CFLA_RS10175	COG0215	cysteine-tRNA ligase activity
CFLA_RS10185	COG0667	Aldo Keto reductase
CFLA_RS10205	COG0339	signal peptide processing
CFLA_RS10210	COG0686	Belongs to the AlaDH PNT family
CFLA_RS10215	COG1522	sequence-specific DNA binding
CFLA_RS10235	COG2267	carboxylic ester hydrolase activity
CFLA_RS10240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFLA_RS10320	COG0587	DNA-directed DNA polymerase activity
CFLA_RS10340	COG0659	secondary active sulfate transmembrane transporter activity
CFLA_RS10345	COG1881	PFAM PEBP family protein
CFLA_RS10395	COG1119	ATPase activity
CFLA_RS10405	COG0187	DNA topoisomerase II activity
CFLA_RS10415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CFLA_RS10420	COG0589	response to stress
CFLA_RS10435	COG0142	geranyltranstransferase activity
CFLA_RS10445	COG0741	lytic transglycosylase activity
CFLA_RS10450	COG2815	serine threonine protein kinase
CFLA_RS10450	COG0515	serine threonine protein kinase
CFLA_RS10455	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CFLA_RS10475	COG1940	carbohydrate kinase activity
CFLA_RS10480	COG1022	Amp-dependent synthetase and ligase
CFLA_RS10495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFLA_RS10505	COG1845	cytochrome c oxidase, subunit III
CFLA_RS10510	COG2010	Cytochrome c
CFLA_RS10515	COG0723	plastoquinol--plastocyanin reductase activity
CFLA_RS10520	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CFLA_RS10535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CFLA_RS10540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CFLA_RS10545	COG1104	cysteine desulfurase activity
CFLA_RS10560	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CFLA_RS10570	COG0824	Thioesterase
CFLA_RS10600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CFLA_RS10610	COG0167	dihydroorotate dehydrogenase activity
CFLA_RS10625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CFLA_RS10635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFLA_RS10640	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFLA_RS10655	COG0673	inositol 2-dehydrogenase activity
CFLA_RS10660	COG2409	Drug exporters of the RND superfamily
CFLA_RS10670	COG0321	lipoyl(octanoyl) transferase activity
CFLA_RS10680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CFLA_RS10695	COG0174	glutamine synthetase
CFLA_RS10710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CFLA_RS10725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CFLA_RS10730	COG0174	glutamine synthetase
CFLA_RS10735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CFLA_RS10765	COG0492	ferredoxin-NADP+ reductase activity
CFLA_RS10770	COG2986	histidine ammonia-lyase
CFLA_RS10790	COG0475	glutathione-regulated potassium exporter activity
CFLA_RS10795	COG0745	RESPONSE REGULATOR receiver
CFLA_RS10825	COG3022	response to hydroperoxide
CFLA_RS10830	COG0406	alpha-ribazole phosphatase activity
CFLA_RS10840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CFLA_RS10840	COG3323	Protein of unknown function (DUF1653)
CFLA_RS10865	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CFLA_RS10885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFLA_RS10890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFLA_RS10985	COG1305	Transglutaminase-like
CFLA_RS10990	COG0358	DNA primase activity
CFLA_RS10995	COG3795	YCII-related domain
CFLA_RS11005	COG3833	ABC-type maltose transport systems, permease component
CFLA_RS11010	COG1175	transmembrane transport
CFLA_RS11025	COG0366	Alpha amylase catalytic
CFLA_RS11030	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CFLA_RS11050	COG0423	glycine-tRNA ligase activity
CFLA_RS11055	COG0803	Belongs to the bacterial solute-binding protein 9 family
CFLA_RS11060	COG1121	(ABC) transporter
CFLA_RS11065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFLA_RS11080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFLA_RS11085	COG1381	Involved in DNA repair and RecF pathway recombination
CFLA_RS11090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFLA_RS11125	COG0714	Associated with various cellular activities
CFLA_RS11155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CFLA_RS11165	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CFLA_RS11175	COG0574	Belongs to the PEP-utilizing enzyme family
CFLA_RS11175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CFLA_RS11185	COG0484	heat shock protein binding
CFLA_RS11190	COG1420	regulation of RNA biosynthetic process
CFLA_RS11200	COG5473	translation initiation factor activity
CFLA_RS11220	COG0481	GTPase activity
CFLA_RS11230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CFLA_RS11235	COG1305	Transglutaminase-like
CFLA_RS11255	COG0268	Binds directly to 16S ribosomal RNA
CFLA_RS11285	COG1596	polysaccharide export
CFLA_RS11285	COG1555	photosystem II stabilization
CFLA_RS11300	COG1307	EDD domain protein, DegV family
CFLA_RS11305	COG0495	leucyl-tRNA aminoacylation
CFLA_RS11310	COG0433	COG0433 Predicted ATPase
CFLA_RS11340	COG0435	Glutathione S-transferase
CFLA_RS11350	COG0513	Belongs to the DEAD box helicase family
CFLA_RS11370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFLA_RS11375	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CFLA_RS11425	COG1222	aaa ATPase
CFLA_RS11505	COG0799	negative regulation of ribosome biogenesis
CFLA_RS11520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CFLA_RS11525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CFLA_RS11530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CFLA_RS11535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CFLA_RS11540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CFLA_RS11545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CFLA_RS11550	COG1530	ribonuclease E activity
CFLA_RS11555	COG1271	oxidase subunit
CFLA_RS11560	COG1294	oxidase, subunit
CFLA_RS11565	COG4988	ABC transporter
CFLA_RS11570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CFLA_RS11585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFLA_RS11590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CFLA_RS11595	COG0571	ribonuclease III activity
CFLA_RS11600	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CFLA_RS11605	COG1399	metal-binding, possibly nucleic acid-binding protein
CFLA_RS11630	COG3268	Saccharopine dehydrogenase
CFLA_RS11635	COG0742	ribosomal rna small subunit methyltransferase
CFLA_RS11645	COG4133	protoheme IX ABC transporter activity
CFLA_RS11660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFLA_RS11680	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFLA_RS11690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CFLA_RS11700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFLA_RS11705	COG0066	3-isopropylmalate dehydratase activity
CFLA_RS11710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFLA_RS11715	COG1414	Transcriptional regulator
CFLA_RS11765	COG0653	protein targeting
CFLA_RS11770	COG3214	Protein conserved in bacteria
CFLA_RS11780	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CFLA_RS11785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFLA_RS11795	COG5000	phosphorelay sensor kinase activity
CFLA_RS11795	COG5002	protein histidine kinase activity
CFLA_RS11800	COG0745	RESPONSE REGULATOR receiver
CFLA_RS11820	COG0714	Associated with various cellular activities
CFLA_RS11840	COG2835	tetraacyldisaccharide 4'-kinase activity
CFLA_RS11885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CFLA_RS11895	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CFLA_RS11915	COG1216	Glycosyl transferase, family 2
CFLA_RS12010	COG0438	transferase activity, transferring glycosyl groups
CFLA_RS12020	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CFLA_RS12025	COG0671	phosphoesterase, PA-phosphatase related
CFLA_RS12050	COG1088	dTDP-glucose 4,6-dehydratase activity
CFLA_RS12055	COG1316	TRANSCRIPTIONal
CFLA_RS12060	COG1316	TRANSCRIPTIONal
CFLA_RS12075	COG1482	cell wall glycoprotein biosynthetic process
CFLA_RS12080	COG2205	protein histidine kinase activity
CFLA_RS12085	COG0745	RESPONSE REGULATOR receiver
CFLA_RS12090	COG4585	Histidine kinase
CFLA_RS12095	COG2197	response regulator
CFLA_RS12100	COG1136	(ABC) transporter
CFLA_RS12100	COG0577	efflux transmembrane transporter activity
CFLA_RS12145	COG0395	ABC-type sugar transport system, permease component
CFLA_RS12160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFLA_RS12170	COG3253	May function as heme-dependent peroxidase
CFLA_RS12175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CFLA_RS12180	COG0515	serine threonine protein kinase
CFLA_RS12205	COG0537	adenosine 5'-monophosphoramidase activity
CFLA_RS12210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CFLA_RS12215	COG0300	oxidoreductase activity
CFLA_RS12220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CFLA_RS12220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CFLA_RS12230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CFLA_RS12275	COG0584	glycerophosphoryl diester phosphodiesterase
CFLA_RS12285	COG1074	ATP-dependent DNA helicase activity
CFLA_RS12290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFLA_RS12310	COG2826	transposase and inactivated derivatives, IS30 family
CFLA_RS12340	COG1012	belongs to the aldehyde dehydrogenase family
CFLA_RS12350	COG2354	Protein conserved in bacteria
CFLA_RS12375	COG0583	DNA-binding transcription factor activity
CFLA_RS12380	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CFLA_RS12395	COG3409	Peptidoglycan-binding domain 1 protein
CFLA_RS12400	COG3409	Peptidoglycan-binding domain 1 protein
CFLA_RS12410	COG1136	(ABC) transporter
CFLA_RS12410	COG0577	efflux transmembrane transporter activity
CFLA_RS12430	COG0697	spore germination
CFLA_RS12435	COG1615	UPF0182 protein
CFLA_RS12445	COG3480	Lon protease (S16) C-terminal proteolytic domain
CFLA_RS12490	COG0210	DNA helicase
CFLA_RS12490	COG0210	DNA helicase
CFLA_RS12515	COG0513	Belongs to the DEAD box helicase family
CFLA_RS12520	COG2095	MarC family integral membrane protein
CFLA_RS12525	COG0613	PHP domain protein
CFLA_RS12530	COG0006	proline dipeptidase activity
CFLA_RS12540	COG2239	Acts as a magnesium transporter
CFLA_RS12555	COG0489	protein tyrosine kinase activity
CFLA_RS12555	COG2151	metal-sulfur cluster biosynthetic enzyme
CFLA_RS12570	COG1349	DNA-binding transcription factor activity
CFLA_RS12580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CFLA_RS12590	COG0577	efflux transmembrane transporter activity
CFLA_RS12590	COG1136	(ABC) transporter
CFLA_RS12610	COG0577	efflux transmembrane transporter activity
CFLA_RS12610	COG1136	(ABC) transporter
CFLA_RS12615	COG0577	efflux transmembrane transporter activity
CFLA_RS12630	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CFLA_RS12635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFLA_RS12675	COG3509	depolymerase
CFLA_RS12690	COG1940	carbohydrate kinase activity
CFLA_RS12695	COG4214	carbohydrate transport
CFLA_RS12705	COG4213	ABC transporter substrate-binding protein
CFLA_RS12715	COG1940	carbohydrate kinase activity
CFLA_RS12720	COG4214	carbohydrate transport
CFLA_RS12730	COG4213	ABC transporter substrate-binding protein
CFLA_RS12740	COG0039	L-malate dehydrogenase activity
CFLA_RS12775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CFLA_RS12790	COG0138	bifunctional purine biosynthesis protein purh
CFLA_RS12815	COG0045	succinate-CoA ligase (ADP-forming) activity
CFLA_RS12845	COG2197	response regulator
CFLA_RS12885	COG0519	Catalyzes the synthesis of GMP from XMP
CFLA_RS12885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFLA_RS12995	COG1132	(ABC) transporter
CFLA_RS13000	COG1132	(ABC) transporter
CFLA_RS13020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CFLA_RS13025	COG1012	belongs to the aldehyde dehydrogenase family
CFLA_RS13035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFLA_RS13040	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFLA_RS13045	COG1120	ATPase activity
CFLA_RS13050	COG0516	GMP reductase activity
CFLA_RS13060	COG2197	response regulator
CFLA_RS13075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CFLA_RS13085	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CFLA_RS13100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CFLA_RS13105	COG0778	Nitroreductase
CFLA_RS13125	COG0802	atpase or kinase
CFLA_RS13130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CFLA_RS13140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CFLA_RS13140	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CFLA_RS13145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFLA_RS13150	COG0736	holo-[acyl-carrier-protein] synthase activity
CFLA_RS13155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFLA_RS13160	COG1072	(Pantothenic acid kinase))
CFLA_RS13180	COG0242	peptide deformylase activity
CFLA_RS13185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFLA_RS13190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CFLA_RS13195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CFLA_RS13200	COG0488	(ABC) transporter
CFLA_RS13210	COG1366	Belongs to the anti-sigma-factor antagonist family
CFLA_RS13220	COG2208	phosphoserine phosphatase activity
CFLA_RS13230	COG0101	tRNA pseudouridine synthase activity
CFLA_RS13255	COG0203	ribosomal protein L17
CFLA_RS13260	COG0202	RNA polymerase activity
CFLA_RS13265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CFLA_RS13270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CFLA_RS13275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CFLA_RS13280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CFLA_RS13290	COG0563	adenylate kinase activity
CFLA_RS13330	COG0200	Binds to the 23S rRNA
CFLA_RS13335	COG1841	ribosomal large subunit assembly
CFLA_RS13340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CFLA_RS13345	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CFLA_RS13350	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CFLA_RS13355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CFLA_RS13365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CFLA_RS13370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CFLA_RS13375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CFLA_RS13380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CFLA_RS13385	COG0255	Belongs to the universal ribosomal protein uL29 family
CFLA_RS13390	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CFLA_RS13395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CFLA_RS13400	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CFLA_RS13405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CFLA_RS13410	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CFLA_RS13415	COG0089	rRNA binding
CFLA_RS13420	COG0088	Forms part of the polypeptide exit tunnel
CFLA_RS13425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CFLA_RS13430	COG0051	transcription antitermination factor activity, RNA binding
CFLA_RS13435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CFLA_RS13440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CFLA_RS13445	COG0049	tRNA binding
CFLA_RS13450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CFLA_RS13460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CFLA_RS13465	COG0085	RNA polymerase activity
CFLA_RS13470	COG0222	ribosome binding
CFLA_RS13475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CFLA_RS13505	COG0081	regulation of translation
CFLA_RS13510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CFLA_RS13530	COG0436	Aminotransferase
CFLA_RS13535	COG1131	(ABC) transporter
CFLA_RS13550	COG2197	response regulator
CFLA_RS13555	COG5002	protein histidine kinase activity
CFLA_RS13560	COG0745	RESPONSE REGULATOR receiver
CFLA_RS13565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CFLA_RS13580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CFLA_RS13590	COG0738	Major facilitator superfamily
CFLA_RS13595	COG1609	Transcriptional regulator
CFLA_RS13605	COG2030	dehydratase
CFLA_RS13610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFLA_RS13635	COG1666	GTP binding
CFLA_RS13640	COG0501	Belongs to the peptidase M48B family
CFLA_RS13660	COG0631	protein serine/threonine phosphatase activity
CFLA_RS13665	COG0142	geranyltranstransferase activity
CFLA_RS13670	COG1007	ATP synthesis coupled electron transport
CFLA_RS13680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFLA_RS13685	COG0713	ATP synthesis coupled electron transport
CFLA_RS13695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFLA_RS13700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CFLA_RS13705	COG1034	ATP synthesis coupled electron transport
CFLA_RS13720	COG0649	NAD binding
CFLA_RS13725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFLA_RS13730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFLA_RS13745	COG2226	methyltransferase
CFLA_RS13755	COG1169	isochorismate synthase
CFLA_RS13760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CFLA_RS13765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CFLA_RS13770	COG4948	Mandelate Racemase Muconate Lactonizing
CFLA_RS13775	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CFLA_RS13810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFLA_RS13815	COG1333	cytochrome c biogenesis protein
CFLA_RS13820	COG0785	Cytochrome C biogenesis protein
CFLA_RS13830	COG0406	alpha-ribazole phosphatase activity
CFLA_RS13840	COG2353	YceI-like domain
CFLA_RS13845	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CFLA_RS13865	COG3345	alpha-galactosidase
CFLA_RS13875	COG0123	including yeast histone deacetylase and acetoin utilization protein
CFLA_RS13880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFLA_RS13885	COG0569	domain protein
CFLA_RS13890	COG2326	polyphosphate kinase activity
CFLA_RS13910	COG2160	L-arabinose isomerase activity
CFLA_RS13930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CFLA_RS13935	COG2890	protein-(glutamine-N5) methyltransferase activity
CFLA_RS13950	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CFLA_RS13955	COG1366	Belongs to the anti-sigma-factor antagonist family
CFLA_RS14000	COG1984	allophanate hydrolase subunit 2
CFLA_RS14005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CFLA_RS14010	COG1205	dead DEAH box helicase
CFLA_RS14010	COG1111	helicase
CFLA_RS14060	COG0154	amidase activity
CFLA_RS14070	COG2351	hydroxyisourate hydrolase activity
CFLA_RS14080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CFLA_RS14085	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CFLA_RS14105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CFLA_RS14125	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CFLA_RS14125	COG3608	succinylglutamate desuccinylase aspartoacylase
CFLA_RS14130	COG0590	tRNA wobble adenosine to inosine editing
CFLA_RS14135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFLA_RS14150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFLA_RS14180	COG0395	ABC-type sugar transport system, permease component
CFLA_RS14185	COG4209	transmembrane transport
CFLA_RS14205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CFLA_RS14225	COG0456	acetyltransferase
CFLA_RS14230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CFLA_RS14240	COG0306	phosphate transporter
CFLA_RS14255	COG0477	Major facilitator Superfamily
CFLA_RS14275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CFLA_RS14335	COG1063	alcohol dehydrogenase
CFLA_RS14360	COG3795	YCII-related domain
CFLA_RS14365	COG2197	response regulator
CFLA_RS14370	COG4585	Histidine kinase
CFLA_RS14385	COG1131	(ABC) transporter
CFLA_RS14395	COG3693	PFAM glycoside hydrolase, family 10
CFLA_RS14460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CFLA_RS14460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFLA_RS14475	COG1272	protein, Hemolysin III
CFLA_RS14515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFLA_RS14525	COG1902	pentaerythritol trinitrate reductase activity
CFLA_RS14535	COG0456	acetyltransferase
CFLA_RS14550	COG2116	formate transmembrane transporter activity
CFLA_RS14570	COG1086	Polysaccharide biosynthesis protein
CFLA_RS14575	COG2258	MOSC domain
CFLA_RS14585	COG2197	response regulator
CFLA_RS14610	COG1233	COG1233 Phytoene dehydrogenase and related
CFLA_RS14640	COG0583	DNA-binding transcription factor activity
CFLA_RS14705	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CFLA_RS14725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFLA_RS14745	COG0557	exoribonuclease II activity
CFLA_RS14750	COG2146	nitrite reductase [NAD(P)H] activity
CFLA_RS14750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFLA_RS14755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CFLA_RS14760	COG0431	NADPH-dependent FMN reductase
CFLA_RS14770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFLA_RS14795	COG0596	Alpha beta hydrolase
CFLA_RS14805	COG0351	phosphomethylpyrimidine kinase
CFLA_RS14840	COG1960	acyl-CoA dehydrogenase activity
CFLA_RS14860	COG2030	dehydratase
CFLA_RS14895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CFLA_RS14910	COG0667	Aldo Keto reductase
CFLA_RS14935	COG0047	phosphoribosylformylglycinamidine synthase activity
CFLA_RS14940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFLA_RS14945	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CFLA_RS14950	COG3591	Belongs to the peptidase S1B family
CFLA_RS14950	COG1864	DNA RNA non-specific endonuclease
CFLA_RS14955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CFLA_RS14960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFLA_RS14965	COG0151	Belongs to the GarS family
CFLA_RS14980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CFLA_RS15035	COG1704	LemA family
CFLA_RS15045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CFLA_RS15060	COG1028	Short-chain dehydrogenase reductase Sdr
CFLA_RS15070	COG0514	ATP-dependent DNA helicase (RecQ)
CFLA_RS15075	COG1609	Transcriptional regulator
CFLA_RS15080	COG4948	Mandelate Racemase Muconate Lactonizing
CFLA_RS15090	COG0667	Aldo Keto reductase
CFLA_RS15100	COG0326	Molecular chaperone. Has ATPase activity
CFLA_RS15160	COG0395	ABC-type sugar transport system, permease component
CFLA_RS15165	COG4209	transmembrane transport
CFLA_RS15170	COG1609	Transcriptional regulator
CFLA_RS15180	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CFLA_RS15195	COG2186	Transcriptional regulator
CFLA_RS15215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CFLA_RS15220	COG0800	Aldolase
CFLA_RS15225	COG1904	glucuronate isomerase
CFLA_RS15235	COG0246	Mannitol dehydrogenase
CFLA_RS15250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFLA_RS15255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CFLA_RS15265	COG0492	ferredoxin-NADP+ reductase activity
CFLA_RS15280	COG1124	(ABC) transporter
CFLA_RS15285	COG3693	PFAM glycoside hydrolase, family 10
CFLA_RS15290	COG1609	Transcriptional regulator
CFLA_RS15320	COG5297	Belongs to the glycosyl hydrolase family 6
CFLA_RS15320	COG3250	beta-galactosidase activity
CFLA_RS15325	COG0110	maltose O-acetyltransferase activity
CFLA_RS15345	COG2409	Drug exporters of the RND superfamily
CFLA_RS15355	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFLA_RS15360	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFLA_RS15370	COG1879	ABC-type sugar transport system periplasmic component
CFLA_RS15375	COG1609	Transcriptional regulator
CFLA_RS15380	COG3401	FG-GAP repeat protein
CFLA_RS15390	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CFLA_RS15400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFLA_RS15410	COG1472	Belongs to the glycosyl hydrolase 3 family
CFLA_RS15415	COG0395	ABC-type sugar transport system, permease component
CFLA_RS15420	COG1175	transmembrane transport
CFLA_RS15435	COG0542	response to heat
CFLA_RS15445	COG2002	toxin-antitoxin pair type II binding
CFLA_RS15470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFLA_RS15495	COG1716	ATPase activity
CFLA_RS15515	COG0824	Thioesterase
CFLA_RS15525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CFLA_RS15535	COG0714	Associated with various cellular activities
CFLA_RS15565	COG0561	phosphatase activity
CFLA_RS15575	COG1490	D-aminoacyl-tRNA deacylase activity
CFLA_RS15590	COG4129	membrane
CFLA_RS15595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CFLA_RS15600	COG3485	protocatechuate 3,4-dioxygenase
CFLA_RS15610	COG0745	RESPONSE REGULATOR receiver
CFLA_RS15615	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CFLA_RS15620	COG0596	Alpha beta hydrolase
CFLA_RS15670	COG2197	response regulator
CFLA_RS15680	COG4733	cellulase activity
CFLA_RS15680	COG5297	Belongs to the glycosyl hydrolase family 6
CFLA_RS15690	COG1131	(ABC) transporter
CFLA_RS15705	COG1131	(ABC) transporter
CFLA_RS15720	COG1028	Short-chain dehydrogenase reductase Sdr
CFLA_RS15760	COG1131	(ABC) transporter
CFLA_RS15775	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CFLA_RS15790	COG1136	(ABC) transporter
CFLA_RS15800	COG1228	amidohydrolase
CFLA_RS15810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CFLA_RS15865	COG1278	Cold shock
CFLA_RS15890	COG4589	Belongs to the CDS family
CFLA_RS15910	COG2233	PERMEase
CFLA_RS15950	COG2365	Tyrosine phosphatase family
CFLA_RS15955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFLA_RS15960	COG2011	ABC-type metal ion transport system permease component
CFLA_RS15965	COG1464	Belongs to the NlpA lipoprotein family
CFLA_RS16005	COG2755	lipolytic protein G-D-S-L family
CFLA_RS16030	COG2018	Roadblock/LC7 domain
CFLA_RS16040	COG2130	NADP-dependent
CFLA_RS16060	COG0395	ABC-type sugar transport system, permease component
CFLA_RS16065	COG1175	transmembrane transport
CFLA_RS16070	COG1653	transport
CFLA_RS16080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CFLA_RS16085	COG1597	lipid kinase activity
CFLA_RS16100	COG1215	transferase activity, transferring glycosyl groups
CFLA_RS16115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CFLA_RS16120	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CFLA_RS16120	COG4124	Belongs to the glycosyl hydrolase 26 family
CFLA_RS16125	COG1215	transferase activity, transferring glycosyl groups
CFLA_RS16135	COG0028	Belongs to the TPP enzyme family
CFLA_RS16145	COG3265	gluconokinase activity
CFLA_RS16160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFLA_RS16175	COG2208	phosphoserine phosphatase activity
CFLA_RS16175	COG2770	Histidine kinase
CFLA_RS16225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFLA_RS16245	COG0702	epimerase
CFLA_RS16260	COG2197	response regulator
CFLA_RS16280	COG0545	Peptidyl-prolyl cis-trans isomerase
CFLA_RS16300	COG1136	(ABC) transporter
CFLA_RS16305	COG0009	L-threonylcarbamoyladenylate synthase
CFLA_RS16325	COG0702	epimerase
CFLA_RS16330	COG1028	Short-chain dehydrogenase reductase Sdr
CFLA_RS16355	COG0477	Major facilitator Superfamily
CFLA_RS16530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFLA_RS16535	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CFLA_RS16555	COG2801	Transposase and inactivated derivatives
CFLA_RS16570	COG2801	Transposase and inactivated derivatives
CFLA_RS16610	COG1111	helicase
CFLA_RS16610	COG1205	dead DEAH box helicase
CFLA_RS16620	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CFLA_RS16625	COG1401	restriction endodeoxyribonuclease activity
CFLA_RS16705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CFLA_RS16760	COG0531	amino acid
CFLA_RS16765	COG1113	amino acid transport
CFLA_RS16775	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CFLA_RS16805	COG2867	negative regulation of translational initiation
CFLA_RS16815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFLA_RS16820	COG4585	Histidine kinase
CFLA_RS16825	COG2197	response regulator
CFLA_RS16840	COG0745	RESPONSE REGULATOR receiver
CFLA_RS16845	COG2205	protein histidine kinase activity
CFLA_RS16850	COG2032	superoxide dismutase activity
CFLA_RS16865	COG0640	Transcriptional regulator
CFLA_RS16885	COG3537	Alpha-1,2-mannosidase
CFLA_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
CFLA_RS16945	COG0395	ABC-type sugar transport system, permease component
CFLA_RS16950	COG1175	transmembrane transport
CFLA_RS16975	COG2223	nitrite transmembrane transporter activity
CFLA_RS16985	COG0534	Mate efflux family protein
CFLA_RS17005	COG0640	Transcriptional regulator
CFLA_RS17010	COG2226	methyltransferase
CFLA_RS17030	COG0508	dehydrogenase complex catalyzes the overall conversion of
CFLA_RS17035	COG0022	dehydrogenase e1 component
CFLA_RS17050	COG1902	pentaerythritol trinitrate reductase activity
CFLA_RS17080	COG1674	ftsk spoiiie
CFLA_RS17100	COG3903	Transcriptional regulator
CFLA_RS17100	COG3629	intracellular signal transduction
CFLA_RS17105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFLA_RS17110	COG1950	PFAM Membrane protein of
CFLA_RS17120	COG0022	dehydrogenase e1 component
CFLA_RS17130	COG1621	beta-fructofuranosidase activity
CFLA_RS17140	COG1172	Belongs to the binding-protein-dependent transport system permease family
CFLA_RS17145	COG4213	ABC transporter substrate-binding protein
CFLA_RS17150	COG1621	beta-fructofuranosidase activity
CFLA_RS17160	COG1950	PFAM Membrane protein of
CFLA_RS17190	COG0714	Associated with various cellular activities
CFLA_RS17205	COG2813	Specifically methylates the guanine in position
CFLA_RS17230	COG2826	transposase and inactivated derivatives, IS30 family
CFLA_RS17270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFLA_RS17280	COG1331	Highly conserved protein containing a thioredoxin domain
CFLA_RS17295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CFLA_RS17300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CFLA_RS17310	COG0181	hydroxymethylbilane synthase activity
CFLA_RS17320	COG0113	porphobilinogen synthase activity
CFLA_RS17325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFLA_RS17330	COG0730	response to heat
CFLA_RS17340	COG1937	Protein conserved in bacteria
CFLA_RS17370	COG1131	(ABC) transporter
CFLA_RS17400	COG3237	CsbD-like
CFLA_RS17410	COG4251	negative regulation of phosphorylation
CFLA_RS17430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFLA_RS17440	COG0710	3-dehydroquinate dehydratase activity
CFLA_RS17445	COG1695	Transcriptional regulator
CFLA_RS17450	COG0628	permease
CFLA_RS17470	COG0697	spore germination
CFLA_RS17490	COG1742	UPF0060 membrane protein
CFLA_RS17495	COG0205	6-phosphofructokinase activity
CFLA_RS17510	COG3655	Transcriptional regulator
CFLA_RS17525	COG1309	transcriptional regulator
CFLA_RS17530	COG1136	(ABC) transporter
CFLA_RS17595	COG0584	glycerophosphoryl diester phosphodiesterase
CFLA_RS17625	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CFLA_RS17640	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CFLA_RS17650	COG0431	NADPH-dependent FMN reductase
CFLA_RS17755	COG0596	Alpha beta hydrolase
CFLA_RS17760	COG3534	alpha-L-arabinofuranosidase
CFLA_RS17765	COG1609	Transcriptional regulator
CFLA_RS17795	COG2205	protein histidine kinase activity
CFLA_RS17800	COG0745	RESPONSE REGULATOR receiver
CFLA_RS17850	COG2382	esterase
CFLA_RS17850	COG3507	Belongs to the glycosyl hydrolase 43 family
CFLA_RS17850	COG3693	PFAM glycoside hydrolase, family 10
CFLA_RS17855	COG1309	transcriptional regulator
CFLA_RS17860	COG1131	(ABC) transporter
CFLA_RS17865	COG3559	Exporter of polyketide antibiotics
CFLA_RS17910	COG0564	pseudouridine synthase activity
CFLA_RS18040	COG1660	Displays ATPase and GTPase activities
CFLA_RS18050	COG0488	(ABC) transporter
CFLA_RS18065	COG0572	uridine kinase
CFLA_RS18080	COG1216	Glycosyl transferase, family 2
CFLA_RS18095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CFLA_RS18130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CFLA_RS18140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFLA_RS18145	COG0275	rRNA processing
CFLA_RS18160	COG0529	Catalyzes the synthesis of activated sulfate
CFLA_RS18230	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CFLA_RS18240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFLA_RS18240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFLA_RS18260	COG0277	FAD linked oxidase domain protein
CFLA_RS18280	COG2271	Major facilitator Superfamily
CFLA_RS18300	COG2304	oxidoreductase activity
CFLA_RS18315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CFLA_RS18325	COG0483	inositol monophosphate 1-phosphatase activity
CFLA_RS18330	COG0667	Aldo Keto reductase
CFLA_RS18335	COG2801	Transposase and inactivated derivatives
CFLA_RS18355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFLA_RS18360	COG0492	ferredoxin-NADP+ reductase activity
CFLA_RS18370	COG0798	PFAM Bile acid sodium symporter
CFLA_RS18375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFLA_RS18380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CFLA_RS18385	COG1247	-acetyltransferase
CFLA_RS18395	COG0640	Transcriptional regulator
CFLA_RS18400	COG0640	Transcriptional regulator
CFLA_RS18415	COG3328	transposase activity
CFLA_RS18430	COG3328	transposase activity
CFLA_RS18435	COG2217	Heavy metal translocating P-type atpase
CFLA_RS18455	COG1937	Protein conserved in bacteria
CFLA_RS18480	COG0745	RESPONSE REGULATOR receiver
CFLA_RS18485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CFLA_RS18495	COG2086	electron transfer activity
CFLA_RS18500	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CFLA_RS18545	COG0534	Mate efflux family protein
CFLA_RS18585	COG0359	binds to the 23S rRNA
CFLA_RS18590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CFLA_RS18600	COG0360	Binds together with S18 to 16S ribosomal RNA
CFLA_RS18605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CFLA_RS18615	COG1260	myo-inositol-1-phosphate synthase
CFLA_RS18645	COG0784	Response regulator, receiver
CFLA_RS18645	COG4191	Histidine kinase
CFLA_RS18660	COG0617	tRNA 3'-terminal CCA addition
CFLA_RS18675	COG0728	peptidoglycan biosynthetic process
CFLA_RS18685	COG0492	ferredoxin-NADP+ reductase activity
CFLA_RS18690	COG3118	belongs to the thioredoxin family
CFLA_RS18700	COG1192	Involved in chromosome partitioning
CFLA_RS18710	COG0357	Ribosomal RNA small subunit methyltransferase G
CFLA_RS18720	COG0706	membrane insertase activity
CFLA_RS18725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CFLA_RS18730	COG0594	ribonuclease P activity
CFLA_RS18735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CFLA_RS18760	COG0515	serine threonine protein kinase
CFLA_RS18775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CFLA_RS18835	COG1876	peptidase activity
CFLA_RS18850	COG0829	nickel cation binding
CFLA_RS18860	COG0830	nickel cation binding
CFLA_RS18885	COG2340	Cysteine-rich secretory protein family
CFLA_RS18915	COG5297	Belongs to the glycosyl hydrolase family 6
CFLA_RS18915	COG4733	cellulase activity
CFLA_RS18960	COG0629	single-stranded DNA binding
CFLA_RS18965	COG5001	Diguanylate cyclase
CFLA_RS18985	COG1388	LysM domain
CFLA_RS18995	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CFLA_RS19010	COG0456	acetyltransferase
CFLA_RS19040	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CFLA_RS19060	COG1461	Dihydroxyacetone kinase
CFLA_RS19075	COG0438	transferase activity, transferring glycosyl groups
CFLA_RS19090	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CFLA_RS19090	COG5479	isomerase activity
CFLA_RS19105	COG3047	cAMP biosynthetic process
CFLA_RS19105	COG2885	chlorophyll binding
CFLA_RS19195	COG1309	transcriptional regulator
CFLA_RS19210	COG4124	Belongs to the glycosyl hydrolase 26 family
CFLA_RS19210	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CFLA_RS19260	COG2226	methyltransferase
CFLA_RS19270	COG0542	response to heat
CFLA_RS19280	COG2304	oxidoreductase activity
CFLA_RS19300	COG0494	nUDIX hydrolase