locus-tag	class	description
GC089_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GC089_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GC089_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GC089_RS00030	COG0187	DNA topoisomerase II activity
GC089_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GC089_RS00040	COG3266	domain, Protein
GC089_RS00055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GC089_RS00095	COG0705	Rhomboid family
GC089_RS00110	COG3764	Sortase (surface protein transpeptidase)
GC089_RS00125	COG2815	serine threonine protein kinase
GC089_RS00125	COG0515	serine threonine protein kinase
GC089_RS00130	COG0515	serine threonine protein kinase
GC089_RS00135	COG0768	penicillin binding
GC089_RS00150	COG1716	ATPase activity
GC089_RS00185	COG2226	methyltransferase
GC089_RS00210	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GC089_RS00230	COG0024	Methionine aminopeptidase
GC089_RS00240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GC089_RS00245	COG0640	Transcriptional regulator
GC089_RS00250	COG2226	methyltransferase
GC089_RS00260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GC089_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS00300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GC089_RS00305	COG0436	Aminotransferase
GC089_RS00315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GC089_RS00320	COG4702	Belongs to the UPF0303 family
GC089_RS00345	COG0039	L-malate dehydrogenase activity
GC089_RS00375	COG0667	Aldo Keto reductase
GC089_RS00385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GC089_RS00385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GC089_RS00390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GC089_RS00395	COG0509	glycine decarboxylation via glycine cleavage system
GC089_RS00400	COG2197	response regulator
GC089_RS00405	COG0494	nUDIX hydrolase
GC089_RS00430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GC089_RS00445	COG0519	Catalyzes the synthesis of GMP from XMP
GC089_RS00520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GC089_RS00560	COG2197	response regulator
GC089_RS00565	COG0702	epimerase
GC089_RS00580	COG0545	Peptidyl-prolyl cis-trans isomerase
GC089_RS00600	COG2364	Membrane
GC089_RS00625	COG1136	(ABC) transporter
GC089_RS00655	COG0009	L-threonylcarbamoyladenylate synthase
GC089_RS00700	COG4085	toxin activity
GC089_RS00700	COG1525	nuclease
GC089_RS00700	COG0737	Belongs to the 5'-nucleotidase family
GC089_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS00740	COG2409	Drug exporters of the RND superfamily
GC089_RS00765	COG0477	Major facilitator Superfamily
GC089_RS00780	COG3537	Alpha-1,2-mannosidase
GC089_RS00805	COG0589	response to stress
GC089_RS00845	COG0395	ABC-type sugar transport system, permease component
GC089_RS00850	COG4209	transmembrane transport
GC089_RS00860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GC089_RS00865	COG1309	transcriptional regulator
GC089_RS00890	COG1017	nitric oxide dioxygenase activity
GC089_RS00890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GC089_RS00900	COG0534	Mate efflux family protein
GC089_RS01040	COG2223	nitrite transmembrane transporter activity
GC089_RS01070	COG1476	TRANSCRIPTIONal
GC089_RS01105	COG1501	Belongs to the glycosyl hydrolase 31 family
GC089_RS01120	COG0531	amino acid
GC089_RS01160	COG0419	ATPase involved in DNA repair
GC089_RS01165	COG0420	3'-5' exonuclease activity
GC089_RS01185	COG0488	(ABC) transporter
GC089_RS01220	COG1643	Atp-dependent helicase
GC089_RS01230	COG3268	Saccharopine dehydrogenase
GC089_RS01245	COG0531	amino acid
GC089_RS01265	COG3265	gluconokinase activity
GC089_RS01270	COG0598	Magnesium transport protein CorA
GC089_RS01295	COG3693	PFAM glycoside hydrolase, family 10
GC089_RS01295	COG2382	esterase
GC089_RS01310	COG1175	transmembrane transport
GC089_RS01315	COG0395	ABC-type sugar transport system, permease component
GC089_RS01360	COG1215	transferase activity, transferring glycosyl groups
GC089_RS01370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GC089_RS01375	COG1215	transferase activity, transferring glycosyl groups
GC089_RS01385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GC089_RS01405	COG1215	transferase activity, transferring glycosyl groups
GC089_RS01415	COG0077	Prephenate dehydratase
GC089_RS01420	COG0477	Major facilitator Superfamily
GC089_RS01425	COG1803	Methylglyoxal synthase
GC089_RS01425	COG1597	lipid kinase activity
GC089_RS01430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GC089_RS01440	COG1653	transport
GC089_RS01445	COG1175	transmembrane transport
GC089_RS01450	COG0395	ABC-type sugar transport system, permease component
GC089_RS01470	COG0604	alcohol dehydrogenase
GC089_RS01470	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS01470	COG3321	synthase
GC089_RS01480	COG2018	Roadblock/LC7 domain
GC089_RS01505	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS01575	COG1464	Belongs to the NlpA lipoprotein family
GC089_RS01580	COG2011	ABC-type metal ion transport system permease component
GC089_RS01585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GC089_RS01640	COG2233	PERMEase
GC089_RS01670	COG1695	Transcriptional regulator
GC089_RS01675	COG1278	Cold shock
GC089_RS01725	COG0501	Belongs to the peptidase M48B family
GC089_RS01745	COG1785	Belongs to the alkaline phosphatase family
GC089_RS01755	COG1609	Transcriptional regulator
GC089_RS01770	COG1129	ABC transporter
GC089_RS01775	COG1172	Belongs to the binding-protein-dependent transport system permease family
GC089_RS01795	COG1129	ABC transporter
GC089_RS01805	COG1136	(ABC) transporter
GC089_RS01830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GC089_RS01845	COG1131	(ABC) transporter
GC089_RS01925	COG2357	RelA SpoT domain protein
GC089_RS01935	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS01950	COG1131	(ABC) transporter
GC089_RS01965	COG1131	(ABC) transporter
GC089_RS01975	COG4733	cellulase activity
GC089_RS01975	COG5297	Belongs to the glycosyl hydrolase family 6
GC089_RS01985	COG2197	response regulator
GC089_RS02005	COG1408	metallophosphoesterase
GC089_RS02045	COG0596	Alpha beta hydrolase
GC089_RS02050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GC089_RS02055	COG0745	RESPONSE REGULATOR receiver
GC089_RS02095	COG1490	D-aminoacyl-tRNA deacylase activity
GC089_RS02115	COG0667	Aldo Keto reductase
GC089_RS02125	COG0561	phosphatase activity
GC089_RS02155	COG0714	Associated with various cellular activities
GC089_RS02165	COG0824	Thioesterase
GC089_RS02170	COG3619	membrane
GC089_RS02180	COG0542	response to heat
GC089_RS02185	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GC089_RS02240	COG0395	ABC-type sugar transport system, permease component
GC089_RS02245	COG1175	transmembrane transport
GC089_RS02255	COG0673	inositol 2-dehydrogenase activity
GC089_RS02265	COG3401	FG-GAP repeat protein
GC089_RS02280	COG1175	transmembrane transport
GC089_RS02285	COG0395	ABC-type sugar transport system, permease component
GC089_RS02315	COG1309	transcriptional regulator
GC089_RS02325	COG0673	inositol 2-dehydrogenase activity
GC089_RS02365	COG0673	inositol 2-dehydrogenase activity
GC089_RS02390	COG0673	inositol 2-dehydrogenase activity
GC089_RS02400	COG3254	rhamnose metabolic process
GC089_RS02405	COG4952	isomerase
GC089_RS02430	COG4608	Belongs to the ABC transporter superfamily
GC089_RS02435	COG0640	Transcriptional regulator
GC089_RS02455	COG0679	Auxin Efflux Carrier
GC089_RS02465	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GC089_RS02490	COG0673	inositol 2-dehydrogenase activity
GC089_RS02495	COG0246	Mannitol dehydrogenase
GC089_RS02500	COG1609	Transcriptional regulator
GC089_RS02505	COG1904	glucuronate isomerase
GC089_RS02510	COG0800	Aldolase
GC089_RS02515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GC089_RS02530	COG2186	Transcriptional regulator
GC089_RS02540	COG0405	Gamma-glutamyltransferase
GC089_RS02550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GC089_RS02555	COG1309	transcriptional regulator
GC089_RS02575	COG1609	Transcriptional regulator
GC089_RS02580	COG1472	Belongs to the glycosyl hydrolase 3 family
GC089_RS02585	COG4209	transmembrane transport
GC089_RS02590	COG0395	ABC-type sugar transport system, permease component
GC089_RS02625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GC089_RS02655	COG2274	protein secretion by the type I secretion system
GC089_RS02675	COG3629	intracellular signal transduction
GC089_RS02690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GC089_RS02715	COG1802	Transcriptional regulator
GC089_RS02720	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GC089_RS02725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GC089_RS02735	COG1335	isochorismatase
GC089_RS02745	COG0667	Aldo Keto reductase
GC089_RS02750	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GC089_RS02755	COG3693	PFAM glycoside hydrolase, family 10
GC089_RS02765	COG4948	Mandelate Racemase Muconate Lactonizing
GC089_RS02770	COG1609	Transcriptional regulator
GC089_RS02775	COG0514	ATP-dependent DNA helicase (RecQ)
GC089_RS02780	COG0300	oxidoreductase activity
GC089_RS02785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GC089_RS02800	COG1704	LemA family
GC089_RS02825	COG1175	transmembrane transport
GC089_RS02830	COG0395	ABC-type sugar transport system, permease component
GC089_RS02875	COG0191	fructose-bisphosphate aldolase activity
GC089_RS02900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GC089_RS02905	COG0151	Belongs to the GarS family
GC089_RS02910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GC089_RS02915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GC089_RS02940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GC089_RS02945	COG0047	phosphoribosylformylglycinamidine synthase activity
GC089_RS02990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GC089_RS03005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GC089_RS03010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GC089_RS03035	COG2030	dehydratase
GC089_RS03045	COG0183	Belongs to the thiolase family
GC089_RS03075	COG4608	Belongs to the ABC transporter superfamily
GC089_RS03080	COG0444	Belongs to the ABC transporter superfamily
GC089_RS03095	COG0747	negative chemotaxis
GC089_RS03100	COG0596	Alpha beta hydrolase
GC089_RS03115	COG0351	phosphomethylpyrimidine kinase
GC089_RS03165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GC089_RS03185	COG1876	peptidase activity
GC089_RS03190	COG1162	GTPase activity
GC089_RS03215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GC089_RS03290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GC089_RS03295	COG0142	geranyltranstransferase activity
GC089_RS03330	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GC089_RS03360	COG1690	Belongs to the RtcB family
GC089_RS03370	COG3012	SEC-C Motif Domain Protein
GC089_RS03390	COG2258	MOSC domain
GC089_RS03395	COG1472	Belongs to the glycosyl hydrolase 3 family
GC089_RS03405	COG3507	Belongs to the glycosyl hydrolase 43 family
GC089_RS03420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GC089_RS03450	COG1136	(ABC) transporter
GC089_RS03490	COG2814	Major facilitator Superfamily
GC089_RS03535	COG1136	(ABC) transporter
GC089_RS03570	COG3693	PFAM glycoside hydrolase, family 10
GC089_RS03575	COG2354	Protein conserved in bacteria
GC089_RS03595	COG3386	PFAM SMP-30 Gluconolaconase
GC089_RS03625	COG2197	response regulator
GC089_RS03635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GC089_RS03640	COG2197	response regulator
GC089_RS03645	COG4585	Histidine kinase
GC089_RS03670	COG1902	pentaerythritol trinitrate reductase activity
GC089_RS03745	COG1309	transcriptional regulator
GC089_RS03750	COG1132	(ABC) transporter
GC089_RS03765	COG1126	abc transporter atp-binding protein
GC089_RS03775	COG2186	Transcriptional regulator
GC089_RS03800	COG0431	NADPH-dependent FMN reductase
GC089_RS03830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GC089_RS03850	COG0477	Major facilitator Superfamily
GC089_RS03865	COG0306	phosphate transporter
GC089_RS03870	COG0667	Aldo Keto reductase
GC089_RS03880	COG0494	nUDIX hydrolase
GC089_RS03880	COG0406	alpha-ribazole phosphatase activity
GC089_RS03885	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GC089_RS03915	COG2116	formate transmembrane transporter activity
GC089_RS03930	COG4209	transmembrane transport
GC089_RS03935	COG0395	ABC-type sugar transport system, permease component
GC089_RS04010	COG1205	dead DEAH box helicase
GC089_RS04010	COG1111	helicase
GC089_RS04015	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GC089_RS04020	COG1984	allophanate hydrolase subunit 2
GC089_RS04050	COG1366	Belongs to the anti-sigma-factor antagonist family
GC089_RS04070	COG2890	protein-(glutamine-N5) methyltransferase activity
GC089_RS04080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GC089_RS04085	COG1609	Transcriptional regulator
GC089_RS04100	COG2160	L-arabinose isomerase activity
GC089_RS04105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GC089_RS04105	COG4124	Belongs to the glycosyl hydrolase 26 family
GC089_RS04125	COG0569	domain protein
GC089_RS04130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GC089_RS04135	COG0123	including yeast histone deacetylase and acetoin utilization protein
GC089_RS04160	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GC089_RS04165	COG2353	YceI-like domain
GC089_RS04185	COG0785	Cytochrome C biogenesis protein
GC089_RS04195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GC089_RS04220	COG1470	cell adhesion involved in biofilm formation
GC089_RS04230	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GC089_RS04235	COG4948	Mandelate Racemase Muconate Lactonizing
GC089_RS04240	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GC089_RS04245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GC089_RS04270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GC089_RS04275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GC089_RS04280	COG0649	NAD binding
GC089_RS04290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GC089_RS04295	COG1034	ATP synthesis coupled electron transport
GC089_RS04300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GC089_RS04305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GC089_RS04315	COG0713	ATP synthesis coupled electron transport
GC089_RS04320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GC089_RS04330	COG1007	ATP synthesis coupled electron transport
GC089_RS04335	COG0142	geranyltranstransferase activity
GC089_RS04340	COG0631	protein serine/threonine phosphatase activity
GC089_RS04360	COG0501	Belongs to the peptidase M48B family
GC089_RS04370	COG1666	GTP binding
GC089_RS04395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GC089_RS04400	COG2030	dehydratase
GC089_RS04410	COG1609	Transcriptional regulator
GC089_RS04415	COG2223	nitrite transmembrane transporter activity
GC089_RS04430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GC089_RS04435	COG0745	RESPONSE REGULATOR receiver
GC089_RS04440	COG5002	protein histidine kinase activity
GC089_RS04445	COG2197	response regulator
GC089_RS04455	COG0842	Transport permease protein
GC089_RS04465	COG0436	Aminotransferase
GC089_RS04485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GC089_RS04490	COG0081	regulation of translation
GC089_RS04515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GC089_RS04520	COG0222	ribosome binding
GC089_RS04535	COG0085	RNA polymerase activity
GC089_RS04540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GC089_RS04545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GC089_RS04550	COG0049	tRNA binding
GC089_RS04555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GC089_RS04560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GC089_RS04585	COG0051	transcription antitermination factor activity, RNA binding
GC089_RS04590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GC089_RS04595	COG0088	Forms part of the polypeptide exit tunnel
GC089_RS04600	COG0089	rRNA binding
GC089_RS04605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GC089_RS04610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GC089_RS04615	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GC089_RS04620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GC089_RS04625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GC089_RS04630	COG0255	Belongs to the universal ribosomal protein uL29 family
GC089_RS04635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GC089_RS04640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GC089_RS04645	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GC089_RS04650	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GC089_RS04660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GC089_RS04665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GC089_RS04670	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GC089_RS04675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GC089_RS04680	COG1841	ribosomal large subunit assembly
GC089_RS04685	COG0200	Binds to the 23S rRNA
GC089_RS04695	COG0563	adenylate kinase activity
GC089_RS04705	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GC089_RS04710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GC089_RS04715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GC089_RS04720	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GC089_RS04725	COG0202	RNA polymerase activity
GC089_RS04730	COG0203	ribosomal protein L17
GC089_RS04755	COG0101	tRNA pseudouridine synthase activity
GC089_RS04770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GC089_RS04775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GC089_RS04780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GC089_RS04785	COG0242	peptide deformylase activity
GC089_RS04805	COG1072	(Pantothenic acid kinase))
GC089_RS04810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GC089_RS04815	COG0736	holo-[acyl-carrier-protein] synthase activity
GC089_RS04830	COG1072	(Pantothenic acid kinase))
GC089_RS04835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GC089_RS04840	COG0802	atpase or kinase
GC089_RS04845	COG1214	PFAM Peptidase M22, glycoprotease
GC089_RS04845	COG0456	acetyltransferase
GC089_RS04860	COG0778	Nitroreductase
GC089_RS04865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GC089_RS04885	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GC089_RS04895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GC089_RS04910	COG2197	response regulator
GC089_RS04920	COG0516	GMP reductase activity
GC089_RS04925	COG1120	ATPase activity
GC089_RS04930	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GC089_RS04935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GC089_RS04945	COG1349	DNA-binding transcription factor activity
GC089_RS04950	COG1105	Belongs to the carbohydrate kinase PfkB family
GC089_RS04960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GC089_RS04960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GC089_RS04960	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GC089_RS04965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GC089_RS04975	COG1012	belongs to the aldehyde dehydrogenase family
GC089_RS04985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GC089_RS04995	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GC089_RS05005	COG1132	(ABC) transporter
GC089_RS05010	COG1132	(ABC) transporter
GC089_RS05020	COG0519	Catalyzes the synthesis of GMP from XMP
GC089_RS05020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GC089_RS05085	COG2337	Toxic component of a toxin-antitoxin (TA) module
GC089_RS05090	COG0045	succinate-CoA ligase (ADP-forming) activity
GC089_RS05145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GC089_RS05155	COG0039	L-malate dehydrogenase activity
GC089_RS05160	COG1872	DUF167
GC089_RS05175	COG4213	ABC transporter substrate-binding protein
GC089_RS05185	COG4214	carbohydrate transport
GC089_RS05225	COG0697	spore germination
GC089_RS05230	COG1846	Transcriptional regulator
GC089_RS05235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GC089_RS05240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GC089_RS05250	COG0708	Exodeoxyribonuclease III
GC089_RS05260	COG0577	efflux transmembrane transporter activity
GC089_RS05260	COG1136	(ABC) transporter
GC089_RS05270	COG0577	efflux transmembrane transporter activity
GC089_RS05275	COG1136	(ABC) transporter
GC089_RS05275	COG0577	efflux transmembrane transporter activity
GC089_RS05290	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GC089_RS05300	COG1349	DNA-binding transcription factor activity
GC089_RS05315	COG2239	Acts as a magnesium transporter
GC089_RS05325	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GC089_RS05330	COG1122	ATPase activity
GC089_RS05345	COG0006	proline dipeptidase activity
GC089_RS05350	COG0613	PHP domain protein
GC089_RS05355	COG2095	MarC family integral membrane protein
GC089_RS05360	COG0513	Belongs to the DEAD box helicase family
GC089_RS05445	COG1615	UPF0182 protein
GC089_RS05450	COG0697	spore germination
GC089_RS05475	COG0500	methyltransferase
GC089_RS05480	COG0405	Gamma-glutamyltransferase
GC089_RS05530	COG0028	Belongs to the TPP enzyme family
GC089_RS05545	COG0543	2 iron, 2 sulfur cluster binding
GC089_RS05545	COG0633	Ferredoxin
GC089_RS05550	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GC089_RS05585	COG0494	nUDIX hydrolase
GC089_RS05595	COG2770	Histidine kinase
GC089_RS05595	COG2208	phosphoserine phosphatase activity
GC089_RS05640	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GC089_RS05655	COG2721	sulfolactate sulfo-lyase activity
GC089_RS05665	COG1609	Transcriptional regulator
GC089_RS05670	COG1609	Transcriptional regulator
GC089_RS05680	COG1074	ATP-dependent DNA helicase activity
GC089_RS05690	COG0584	glycerophosphoryl diester phosphodiesterase
GC089_RS05695	COG0584	glycerophosphoryl diester phosphodiesterase
GC089_RS05700	COG0789	Transcriptional regulator
GC089_RS05720	COG0726	polysaccharide deacetylase
GC089_RS05760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GC089_RS05800	COG0300	oxidoreductase activity
GC089_RS05815	COG0537	adenosine 5'-monophosphoramidase activity
GC089_RS05840	COG0515	serine threonine protein kinase
GC089_RS05840	COG2815	serine threonine protein kinase
GC089_RS05845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GC089_RS05850	COG3253	May function as heme-dependent peroxidase
GC089_RS05860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GC089_RS05920	COG1136	(ABC) transporter
GC089_RS05920	COG0577	efflux transmembrane transporter activity
GC089_RS05925	COG2197	response regulator
GC089_RS05930	COG4585	Histidine kinase
GC089_RS05935	COG0745	RESPONSE REGULATOR receiver
GC089_RS05940	COG2205	protein histidine kinase activity
GC089_RS05945	COG1482	cell wall glycoprotein biosynthetic process
GC089_RS05965	COG1316	TRANSCRIPTIONal
GC089_RS05970	COG1316	TRANSCRIPTIONal
GC089_RS05975	COG1088	dTDP-glucose 4,6-dehydratase activity
GC089_RS05985	COG0438	transferase activity, transferring glycosyl groups
GC089_RS05985	COG1216	Glycosyl transferase, family 2
GC089_RS06050	COG1216	Glycosyl transferase, family 2
GC089_RS06065	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GC089_RS06075	COG0463	Glycosyl transferase, family 2
GC089_RS06095	COG0673	inositol 2-dehydrogenase activity
GC089_RS06100	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GC089_RS06150	COG2835	tetraacyldisaccharide 4'-kinase activity
GC089_RS06170	COG0714	Associated with various cellular activities
GC089_RS06190	COG0745	RESPONSE REGULATOR receiver
GC089_RS06195	COG5002	protein histidine kinase activity
GC089_RS06200	COG5401	PFAM Sporulation and spore germination
GC089_RS06210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GC089_RS06215	COG3214	Protein conserved in bacteria
GC089_RS06280	COG1414	Transcriptional regulator
GC089_RS06285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GC089_RS06290	COG0066	3-isopropylmalate dehydratase activity
GC089_RS06295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GC089_RS06305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GC089_RS06315	COG1181	Belongs to the D-alanine--D-alanine ligase family
GC089_RS06335	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GC089_RS06340	COG1461	Dihydroxyacetone kinase
GC089_RS06360	COG0742	ribosomal rna small subunit methyltransferase
GC089_RS06370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GC089_RS06385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GC089_RS06390	COG0571	ribonuclease III activity
GC089_RS06415	COG1132	(ABC) transporter
GC089_RS06420	COG4988	ABC transporter
GC089_RS06425	COG1294	oxidase, subunit
GC089_RS06430	COG1271	oxidase subunit
GC089_RS06440	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GC089_RS06445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GC089_RS06450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GC089_RS06455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GC089_RS06460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GC089_RS06465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GC089_RS06475	COG0799	negative regulation of ribosome biogenesis
GC089_RS06500	COG0745	RESPONSE REGULATOR receiver
GC089_RS06505	COG2205	protein histidine kinase activity
GC089_RS06525	COG1136	(ABC) transporter
GC089_RS06525	COG0577	efflux transmembrane transporter activity
GC089_RS06540	COG0702	epimerase
GC089_RS06545	COG2514	catechol 2,3-dioxygenase activity
GC089_RS06550	COG2259	Doxx family
GC089_RS06575	COG4941	Belongs to the sigma-70 factor family
GC089_RS06580	COG3795	YCII-related domain
GC089_RS06595	COG2814	Major facilitator Superfamily
GC089_RS06600	COG1349	DNA-binding transcription factor activity
GC089_RS06605	COG1554	hydrolase, family 65, central catalytic
GC089_RS06615	COG0028	Belongs to the TPP enzyme family
GC089_RS06620	COG2315	Protein conserved in bacteria
GC089_RS06625	COG3279	Response regulator of the LytR AlgR family
GC089_RS06645	COG1472	Belongs to the glycosyl hydrolase 3 family
GC089_RS06660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GC089_RS06705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GC089_RS06715	COG2816	NAD+ diphosphatase activity
GC089_RS06730	COG3866	Pectate lyase
GC089_RS06740	COG2514	catechol 2,3-dioxygenase activity
GC089_RS06755	COG4721	ABC-type cobalt transport system, permease component
GC089_RS06775	COG0435	Glutathione S-transferase
GC089_RS06830	COG1307	EDD domain protein, DegV family
GC089_RS06835	COG1596	polysaccharide export
GC089_RS06835	COG1555	photosystem II stabilization
GC089_RS06865	COG0268	Binds directly to 16S ribosomal RNA
GC089_RS06880	COG1305	Transglutaminase-like
GC089_RS06890	COG0481	GTPase activity
GC089_RS06935	COG1420	regulation of RNA biosynthetic process
GC089_RS06940	COG0484	heat shock protein binding
GC089_RS06950	COG0574	Belongs to the PEP-utilizing enzyme family
GC089_RS06950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GC089_RS06960	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GC089_RS06970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GC089_RS06980	COG0631	protein serine/threonine phosphatase activity
GC089_RS07005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GC089_RS07010	COG1381	Involved in DNA repair and RecF pathway recombination
GC089_RS07015	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GC089_RS07035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GC089_RS07040	COG1121	(ABC) transporter
GC089_RS07045	COG0803	Belongs to the bacterial solute-binding protein 9 family
GC089_RS07050	COG0423	glycine-tRNA ligase activity
GC089_RS07055	COG3541	Predicted nucleotidyltransferase
GC089_RS07065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GC089_RS07065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GC089_RS07070	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GC089_RS07075	COG0366	Alpha amylase catalytic
GC089_RS07090	COG1175	transmembrane transport
GC089_RS07095	COG3833	ABC-type maltose transport systems, permease component
GC089_RS07100	COG0366	Alpha amylase catalytic
GC089_RS07110	COG3795	YCII-related domain
GC089_RS07120	COG0358	DNA primase activity
GC089_RS07125	COG1305	Transglutaminase-like
GC089_RS07150	COG0596	Alpha beta hydrolase
GC089_RS07250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GC089_RS07255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GC089_RS07260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GC089_RS07280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GC089_RS07325	COG0346	lactoylglutathione lyase activity
GC089_RS07330	COG3022	response to hydroperoxide
GC089_RS07345	COG0346	lactoylglutathione lyase activity
GC089_RS07395	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GC089_RS07400	COG0174	glutamine synthetase
GC089_RS07405	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GC089_RS07425	COG0174	glutamine synthetase
GC089_RS07435	COG2267	carboxylic ester hydrolase activity
GC089_RS07445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GC089_RS07455	COG0321	lipoyl(octanoyl) transferase activity
GC089_RS07460	COG1846	Transcriptional regulator
GC089_RS07470	COG0673	inositol 2-dehydrogenase activity
GC089_RS07485	COG0508	dehydrogenase complex catalyzes the overall conversion of
GC089_RS07490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GC089_RS07500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GC089_RS07515	COG0167	dihydroorotate dehydrogenase activity
GC089_RS07555	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GC089_RS07570	COG0425	Belongs to the sulfur carrier protein TusA family
GC089_RS07580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GC089_RS07585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GC089_RS07605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GC089_RS07610	COG0723	plastoquinol--plastocyanin reductase activity
GC089_RS07615	COG2010	Cytochrome c
GC089_RS07620	COG1845	cytochrome c oxidase, subunit III
GC089_RS07650	COG1022	Amp-dependent synthetase and ligase
GC089_RS07675	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GC089_RS07680	COG2815	serine threonine protein kinase
GC089_RS07680	COG0515	serine threonine protein kinase
GC089_RS07685	COG0741	lytic transglycosylase activity
GC089_RS07695	COG0142	geranyltranstransferase activity
GC089_RS07710	COG0589	response to stress
GC089_RS07715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GC089_RS07725	COG0187	DNA topoisomerase II activity
GC089_RS07735	COG1119	ATPase activity
GC089_RS07790	COG2860	membrane
GC089_RS07810	COG0587	DNA-directed DNA polymerase activity
GC089_RS07835	COG1397	ADP-ribosylglycohydrolase
GC089_RS07870	COG0740	serine-type endopeptidase activity
GC089_RS07875	COG0740	serine-type endopeptidase activity
GC089_RS07880	COG2267	carboxylic ester hydrolase activity
GC089_RS07900	COG0686	Belongs to the AlaDH PNT family
GC089_RS07905	COG0339	signal peptide processing
GC089_RS07925	COG0667	Aldo Keto reductase
GC089_RS07935	COG0215	cysteine-tRNA ligase activity
GC089_RS07950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GC089_RS07965	COG1222	aaa ATPase
GC089_RS07970	COG4122	O-methyltransferase activity
GC089_RS07985	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GC089_RS07990	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GC089_RS07995	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GC089_RS08005	COG0107	imidazoleglycerol-phosphate synthase activity
GC089_RS08020	COG1132	(ABC) transporter
GC089_RS08060	COG0134	indole-3-glycerol-phosphate synthase activity
GC089_RS08065	COG0133	tryptophan synthase activity
GC089_RS08070	COG0159	tryptophan synthase activity
GC089_RS08075	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GC089_RS08080	COG0067	glutamate synthase
GC089_RS08080	COG0069	glutamate synthase activity
GC089_RS08080	COG0070	glutamate synthase
GC089_RS08120	COG1653	transport
GC089_RS08165	COG2050	protein possibly involved in aromatic compounds catabolism
GC089_RS08180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GC089_RS08185	COG2226	methyltransferase
GC089_RS08190	COG0747	negative chemotaxis
GC089_RS08195	COG0601	transmembrane transport
GC089_RS08200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GC089_RS08215	COG0539	negative regulation of cytoplasmic translation
GC089_RS08220	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GC089_RS08220	COG0237	dephospho-CoA kinase activity
GC089_RS08230	COG0556	nucleotide-excision repair
GC089_RS08260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GC089_RS08265	COG3387	PFAM Glycoside hydrolase 15-related
GC089_RS08280	COG0322	excinuclease ABC activity
GC089_RS08295	COG1481	regulation of sporulation
GC089_RS08300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GC089_RS08305	COG0126	phosphoglycerate kinase activity
GC089_RS08310	COG0149	triose-phosphate isomerase activity
GC089_RS08315	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GC089_RS08325	COG0363	glucosamine-6-phosphate deaminase activity
GC089_RS08340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GC089_RS08350	COG0109	protoheme IX farnesyltransferase activity
GC089_RS08365	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GC089_RS08370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GC089_RS08385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GC089_RS08395	COG1160	GTP binding
GC089_RS08415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GC089_RS08425	COG1309	transcriptional regulator
GC089_RS08430	COG4221	oxidoreductase activity
GC089_RS08450	COG3639	organic phosphonate transmembrane transporter activity
GC089_RS08475	COG1609	Transcriptional regulator
GC089_RS08485	COG1653	transport
GC089_RS08495	COG0395	ABC-type sugar transport system, permease component
GC089_RS08500	COG5578	integral membrane protein
GC089_RS08520	COG0753	catalase activity
GC089_RS08545	COG1609	Transcriptional regulator
GC089_RS08550	COG0366	Alpha amylase catalytic
GC089_RS08555	COG2223	nitrite transmembrane transporter activity
GC089_RS08565	COG0531	amino acid
GC089_RS08575	COG2235	arginine
GC089_RS08590	COG2197	response regulator
GC089_RS08605	COG1404	Belongs to the peptidase S8 family
GC089_RS08610	COG1404	Belongs to the peptidase S8 family
GC089_RS08625	COG1609	Transcriptional regulator
GC089_RS08630	COG1879	ABC-type sugar transport system periplasmic component
GC089_RS08640	COG1172	Belongs to the binding-protein-dependent transport system permease family
GC089_RS08660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GC089_RS08680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GC089_RS08710	COG0515	serine threonine protein kinase
GC089_RS08745	COG1595	DNA-templated transcription, initiation
GC089_RS08750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GC089_RS08750	COG2169	Transcriptional regulator
GC089_RS08765	COG0579	oxidoreductase
GC089_RS08785	COG0783	Belongs to the Dps family
GC089_RS08790	COG3285	dna ligase
GC089_RS08790	COG1793	dna ligase
GC089_RS08795	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GC089_RS08800	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GC089_RS08800	COG1796	DNA polymerase
GC089_RS08820	COG5297	Belongs to the glycosyl hydrolase family 6
GC089_RS08825	COG1609	Transcriptional regulator
GC089_RS08840	COG1832	CoA-binding protein
GC089_RS08890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GC089_RS08905	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS08920	COG0667	Aldo Keto reductase
GC089_RS08950	COG0805	protein transport
GC089_RS08955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GC089_RS08985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GC089_RS08990	COG0140	phosphoribosyl-ATP diphosphatase activity
GC089_RS09000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GC089_RS09005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GC089_RS09005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GC089_RS09020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GC089_RS09040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GC089_RS09050	COG1758	RNA polymerase activity
GC089_RS09055	COG0194	GDP metabolic process
GC089_RS09065	COG0284	orotidine-5'-phosphate decarboxylase activity
GC089_RS09070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GC089_RS09075	COG0505	Belongs to the CarA family
GC089_RS09085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GC089_RS09090	COG0540	Belongs to the ATCase OTCase family
GC089_RS09095	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GC089_RS09100	COG5001	Diguanylate cyclase
GC089_RS09105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GC089_RS09110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GC089_RS09130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GC089_RS09145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GC089_RS09180	COG2165	general secretion pathway protein
GC089_RS09185	COG1459	type II secretion system
GC089_RS09195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GC089_RS09200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GC089_RS09210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GC089_RS09215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GC089_RS09230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GC089_RS09240	COG2409	Drug exporters of the RND superfamily
GC089_RS09265	COG0124	histidyl-tRNA synthetase
GC089_RS09270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GC089_RS09280	COG1196	nuclear chromosome segregation
GC089_RS09295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GC089_RS09315	COG2255	four-way junction helicase activity
GC089_RS09320	COG0632	four-way junction helicase activity
GC089_RS09325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GC089_RS09330	COG0217	transcriptional regulatory protein
GC089_RS09335	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GC089_RS09340	COG0494	nUDIX hydrolase
GC089_RS09345	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GC089_RS09355	COG0438	transferase activity, transferring glycosyl groups
GC089_RS09360	COG1560	Kdo2-lipid A biosynthetic process
GC089_RS09365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GC089_RS09375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GC089_RS09430	COG2323	membrane
GC089_RS09455	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GC089_RS09465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GC089_RS09470	COG1132	(ABC) transporter
GC089_RS09475	COG1132	(ABC) transporter
GC089_RS09500	COG2326	polyphosphate kinase activity
GC089_RS09520	COG0577	efflux transmembrane transporter activity
GC089_RS09525	COG1136	(ABC) transporter
GC089_RS09590	COG1331	Highly conserved protein containing a thioredoxin domain
GC089_RS09610	COG1216	Glycosyl transferase, family 2
GC089_RS09615	COG3546	catalase activity
GC089_RS09660	COG0395	ABC-type sugar transport system, permease component
GC089_RS09665	COG1175	transmembrane transport
GC089_RS09690	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GC089_RS09700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GC089_RS09705	COG0859	PFAM glycosyl transferase family 9
GC089_RS09715	COG0438	transferase activity, transferring glycosyl groups
GC089_RS09725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GC089_RS09725	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GC089_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS09785	COG2223	nitrite transmembrane transporter activity
GC089_RS09800	COG0521	Mo-molybdopterin cofactor biosynthetic process
GC089_RS09800	COG0315	cyclic pyranopterin monophosphate synthase activity
GC089_RS09805	COG0315	cyclic pyranopterin monophosphate synthase activity
GC089_RS09815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GC089_RS09825	COG0314	molybdopterin synthase activity
GC089_RS09865	COG0463	Glycosyl transferase, family 2
GC089_RS09870	COG1305	Transglutaminase-like
GC089_RS09895	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GC089_RS09900	COG0175	sulfate reduction
GC089_RS09915	COG1648	precorrin-2 dehydrogenase activity
GC089_RS09915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GC089_RS09940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GC089_RS09950	COG2197	response regulator
GC089_RS09955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GC089_RS09960	COG0183	Belongs to the thiolase family
GC089_RS09965	COG1250	3-hydroxyacyl-CoA dehydrogenase
GC089_RS09965	COG1024	Enoyl-CoA hydratase
GC089_RS09975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GC089_RS09980	COG1882	Formate acetyltransferase
GC089_RS09985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GC089_RS10010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GC089_RS10010	COG0519	Catalyzes the synthesis of GMP from XMP
GC089_RS10030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GC089_RS10040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GC089_RS10045	COG0531	amino acid
GC089_RS10050	COG0569	domain protein
GC089_RS10075	COG0756	dUTP diphosphatase activity
GC089_RS10090	COG0483	inositol monophosphate 1-phosphatase activity
GC089_RS10100	COG1435	thymidine kinase activity
GC089_RS10115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GC089_RS10130	COG0297	glycogen (starch) synthase activity
GC089_RS10150	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GC089_RS10155	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS10175	COG0488	(ABC) transporter
GC089_RS10180	COG1268	BioY protein
GC089_RS10185	COG1122	ATPase activity
GC089_RS10200	COG2151	metal-sulfur cluster biosynthetic enzyme
GC089_RS10205	COG0822	iron-sulfur transferase activity
GC089_RS10215	COG0396	ATPase activity
GC089_RS10225	COG0719	Fe-S assembly protein
GC089_RS10260	COG0494	nUDIX hydrolase
GC089_RS10265	COG0504	CTP synthase activity
GC089_RS10295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GC089_RS10310	COG0647	UMP catabolic process
GC089_RS10335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GC089_RS10340	COG2094	Belongs to the DNA glycosylase MPG family
GC089_RS10350	COG0165	Argininosuccinate lyase
GC089_RS10355	COG0137	argininosuccinate synthase activity
GC089_RS10360	COG1438	arginine binding
GC089_RS10365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GC089_RS10380	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GC089_RS10385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GC089_RS10405	COG0352	thiamine-phosphate diphosphorylase activity
GC089_RS10410	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GC089_RS10440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GC089_RS10445	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GC089_RS10495	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GC089_RS10500	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GC089_RS10515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GC089_RS10520	COG0514	ATP-dependent DNA helicase (RecQ)
GC089_RS10525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GC089_RS10530	COG2501	S4 domain
GC089_RS10535	COG0587	DNA-directed DNA polymerase activity
GC089_RS10545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GC089_RS10550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GC089_RS10555	COG3599	regulation of cell shape
GC089_RS10565	COG1799	cell septum assembly
GC089_RS10575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GC089_RS10580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GC089_RS10585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GC089_RS10595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GC089_RS10600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GC089_RS10610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GC089_RS10615	COG0768	penicillin binding
GC089_RS10625	COG0275	rRNA processing
GC089_RS10630	COG2001	Belongs to the MraZ family
GC089_RS10635	COG0714	Associated with various cellular activities
GC089_RS10655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GC089_RS10665	COG1278	Cold shock
GC089_RS10675	COG0784	Response regulator, receiver
GC089_RS10680	COG4251	negative regulation of phosphorylation
GC089_RS10685	COG0745	RESPONSE REGULATOR receiver
GC089_RS10710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GC089_RS10720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GC089_RS10730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GC089_RS10745	COG4946	Tricorn protease homolog
GC089_RS10745	COG1506	peptidase
GC089_RS10745	COG0823	Involved in the tonB-independent uptake of proteins
GC089_RS10750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GC089_RS10755	COG2813	Specifically methylates the guanine in position
GC089_RS10770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GC089_RS10795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GC089_RS10800	COG1126	abc transporter atp-binding protein
GC089_RS10805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GC089_RS10810	COG0765	amino acid transport
GC089_RS10815	COG0765	amino acid transport
GC089_RS10820	COG1418	mRNA catabolic process
GC089_RS10830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GC089_RS10845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GC089_RS10850	COG1396	sequence-specific DNA binding
GC089_RS10855	COG1546	Belongs to the CinA family
GC089_RS10855	COG1058	Belongs to the CinA family
GC089_RS10895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GC089_RS10930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GC089_RS10935	COG0612	Peptidase, M16
GC089_RS10940	COG1185	polyribonucleotide nucleotidyltransferase activity
GC089_RS10945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GC089_RS10955	COG5297	Belongs to the glycosyl hydrolase family 6
GC089_RS10955	COG3250	beta-galactosidase activity
GC089_RS10960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GC089_RS10965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GC089_RS10985	COG0779	Required for maturation of 30S ribosomal subunits
GC089_RS11000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GC089_RS11010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GC089_RS11015	COG0750	zinc metalloprotease
GC089_RS11025	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GC089_RS11035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GC089_RS11045	COG0233	cytoplasmic translational termination
GC089_RS11055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GC089_RS11060	COG0052	Belongs to the universal ribosomal protein uS2 family
GC089_RS11070	COG1191	sigma factor activity
GC089_RS11090	COG0792	nuclease activity
GC089_RS11100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GC089_RS11105	COG0681	Belongs to the peptidase S26 family
GC089_RS11110	COG0335	large ribosomal subunit rRNA binding
GC089_RS11115	COG0336	Belongs to the RNA methyltransferase TrmD family
GC089_RS11120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GC089_RS11125	COG1837	Belongs to the UPF0109 family
GC089_RS11130	COG0228	four-way junction DNA binding
GC089_RS11145	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GC089_RS11170	COG1196	nuclear chromosome segregation
GC089_RS11175	COG0105	UTP biosynthetic process
GC089_RS11225	COG1461	Dihydroxyacetone kinase
GC089_RS11230	COG2376	Dihydroxyacetone kinase
GC089_RS11235	COG0285	dihydrofolate synthase activity
GC089_RS11240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GC089_RS11255	COG2116	formate transmembrane transporter activity
GC089_RS11295	COG0789	Transcriptional regulator
GC089_RS11315	COG2197	response regulator
GC089_RS11320	COG1132	(ABC) transporter
GC089_RS11340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GC089_RS11345	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GC089_RS11350	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GC089_RS11355	COG1920	GTP binding
GC089_RS11415	COG0778	Nitroreductase
GC089_RS11415	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GC089_RS11420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GC089_RS11430	COG1476	TRANSCRIPTIONal
GC089_RS11470	COG0525	valine-tRNA ligase activity
GC089_RS11480	COG0765	amino acid transport
GC089_RS11490	COG1022	Amp-dependent synthetase and ligase
GC089_RS11500	COG1605	Chorismate mutase
GC089_RS11500	COG0287	Prephenate dehydrogenase
GC089_RS11505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GC089_RS11510	COG0740	serine-type endopeptidase activity
GC089_RS11515	COG0740	serine-type endopeptidase activity
GC089_RS11520	COG0544	peptidyl-prolyl cis-trans isomerase activity
GC089_RS11550	COG1045	serine acetyltransferase
GC089_RS11575	COG1116	anion transmembrane transporter activity
GC089_RS11585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GC089_RS11590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GC089_RS11600	COG1832	CoA-binding protein
GC089_RS11615	COG4552	Acetyltransferase involved in intracellular survival and related
GC089_RS11625	COG3590	peptidase
GC089_RS11655	COG1505	serine-type exopeptidase activity
GC089_RS11660	COG0668	transmembrane transport
GC089_RS11665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GC089_RS11665	COG1263	PTS System
GC089_RS11665	COG2190	(PTS) system
GC089_RS11670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GC089_RS11675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GC089_RS11685	COG1946	Acyl-CoA thioesterase
GC089_RS11695	COG0702	epimerase
GC089_RS11705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GC089_RS11725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GC089_RS11730	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GC089_RS11775	COG1174	glycine betaine transport
GC089_RS11785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GC089_RS11805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GC089_RS11825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GC089_RS11840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GC089_RS11845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GC089_RS11855	COG1234	tRNA 3'-trailer cleavage
GC089_RS11860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GC089_RS11870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GC089_RS11900	COG1725	Transcriptional regulator
GC089_RS11905	COG0363	glucosamine-6-phosphate deaminase activity
GC089_RS11915	COG0395	ABC-type sugar transport system, permease component
GC089_RS11920	COG1175	transmembrane transport
GC089_RS11930	COG1940	carbohydrate kinase activity
GC089_RS11930	COG1846	Transcriptional regulator
GC089_RS11935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GC089_RS11940	COG5297	Belongs to the glycosyl hydrolase family 6
GC089_RS11950	COG0166	Belongs to the GPI family
GC089_RS11990	COG1854	S-ribosylhomocysteine lyase activity
GC089_RS11995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GC089_RS12000	COG2814	Major facilitator Superfamily
GC089_RS12010	COG2267	carboxylic ester hydrolase activity
GC089_RS12015	COG1012	belongs to the aldehyde dehydrogenase family
GC089_RS12020	COG2205	protein histidine kinase activity
GC089_RS12025	COG0745	RESPONSE REGULATOR receiver
GC089_RS12060	COG1254	Belongs to the acylphosphatase family
GC089_RS12080	COG2267	carboxylic ester hydrolase activity
GC089_RS12085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GC089_RS12090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GC089_RS12115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GC089_RS12130	COG5002	protein histidine kinase activity
GC089_RS12140	COG1215	transferase activity, transferring glycosyl groups
GC089_RS12145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GC089_RS12160	COG1823	symporter activity
GC089_RS12170	COG4585	Histidine kinase
GC089_RS12175	COG2197	response regulator
GC089_RS12195	COG0738	Major facilitator superfamily
GC089_RS12220	COG2409	Drug exporters of the RND superfamily
GC089_RS12235	COG4585	Histidine kinase
GC089_RS12240	COG2197	response regulator
GC089_RS12250	COG0604	alcohol dehydrogenase
GC089_RS12315	COG1793	dna ligase
GC089_RS12330	COG0514	ATP-dependent DNA helicase (RecQ)
GC089_RS12380	COG1609	Transcriptional regulator
GC089_RS12430	COG1132	(ABC) transporter
GC089_RS12440	COG1078	dGTPase activity
GC089_RS12445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GC089_RS12450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GC089_RS12455	COG0673	inositol 2-dehydrogenase activity
GC089_RS12460	COG1051	belongs to the nudix hydrolase family
GC089_RS12465	COG2017	converts alpha-aldose to the beta-anomer
GC089_RS12480	COG1253	flavin adenine dinucleotide binding
GC089_RS12485	COG0745	RESPONSE REGULATOR receiver
GC089_RS12490	COG2205	protein histidine kinase activity
GC089_RS12505	COG0508	dehydrogenase complex catalyzes the overall conversion of
GC089_RS12505	COG0567	Dehydrogenase, E1 component
GC089_RS12530	COG1595	DNA-templated transcription, initiation
GC089_RS12550	COG0483	inositol monophosphate 1-phosphatase activity
GC089_RS12565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GC089_RS12570	COG1115	amino acid carrier protein
GC089_RS12575	COG0179	Fumarylacetoacetate (FAA) hydrolase
GC089_RS12625	COG0259	pyridoxamine-phosphate oxidase activity
GC089_RS12640	COG0328	RNA-DNA hybrid ribonuclease activity
GC089_RS12645	COG0318	PFAM AMP-dependent synthetase and ligase
GC089_RS12670	COG3304	Inner membrane component domain
GC089_RS12675	COG1678	Uncharacterized ACR, COG1678
GC089_RS12705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GC089_RS12720	COG0473	3-isopropylmalate dehydrogenase activity
GC089_RS12730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GC089_RS12755	COG1755	Isoprenylcysteine carboxyl methyltransferase
GC089_RS12775	COG1131	(ABC) transporter
GC089_RS12780	COG0366	Alpha amylase catalytic
GC089_RS12790	COG0129	dihydroxy-acid dehydratase activity
GC089_RS12800	COG0129	dihydroxy-acid dehydratase activity
GC089_RS12805	COG1472	Belongs to the glycosyl hydrolase 3 family
GC089_RS12810	COG0395	ABC-type sugar transport system, permease component
GC089_RS12815	COG1175	transmembrane transport
GC089_RS12830	COG3104	oligopeptide transport
GC089_RS12845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GC089_RS12850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GC089_RS12855	COG0154	amidase activity
GC089_RS12860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GC089_RS12880	COG1879	ABC-type sugar transport system periplasmic component
GC089_RS12885	COG1172	Belongs to the binding-protein-dependent transport system permease family
GC089_RS12895	COG1129	ABC transporter
GC089_RS12900	COG1940	carbohydrate kinase activity
GC089_RS12935	COG1674	ftsk spoiiie
GC089_RS12955	COG1404	Belongs to the peptidase S8 family
GC089_RS12985	COG1404	Belongs to the peptidase S8 family
GC089_RS13015	COG0714	Associated with various cellular activities
GC089_RS13050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GC089_RS13075	COG0366	Alpha amylase catalytic
GC089_RS13080	COG0366	Alpha amylase catalytic
GC089_RS13085	COG3281	Trehalose synthase
GC089_RS13095	COG2182	Extracellular solute-binding protein
GC089_RS13100	COG1175	transmembrane transport
GC089_RS13105	COG0395	ABC-type sugar transport system, permease component
GC089_RS13115	COG1609	Transcriptional regulator
GC089_RS13170	COG0561	phosphatase activity
GC089_RS13185	COG1501	Belongs to the glycosyl hydrolase 31 family
GC089_RS13195	COG1609	Transcriptional regulator
GC089_RS13200	COG0395	ABC-type sugar transport system, permease component
GC089_RS13205	COG4209	transmembrane transport
GC089_RS13240	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GC089_RS13250	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GC089_RS13255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GC089_RS13260	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GC089_RS13265	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GC089_RS13270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GC089_RS13280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GC089_RS13285	COG0356	it plays a direct role in the translocation of protons across the membrane
GC089_RS13295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GC089_RS13305	COG2890	protein-(glutamine-N5) methyltransferase activity
GC089_RS13310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GC089_RS13315	COG0254	rRNA binding
GC089_RS13325	COG0083	homoserine kinase activity
GC089_RS13330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GC089_RS13335	COG0460	homoserine dehydrogenase
GC089_RS13340	COG0019	diaminopimelate decarboxylase activity
GC089_RS13345	COG0018	arginyl-trna synthetase
GC089_RS13350	COG2186	Transcriptional regulator
GC089_RS13375	COG1131	(ABC) transporter
GC089_RS13400	COG2197	response regulator
GC089_RS13405	COG2249	NAD(P)H dehydrogenase (quinone) activity
GC089_RS13415	COG2154	pterin-4-alpha-carbinolamine dehydratase
GC089_RS13430	COG1012	belongs to the aldehyde dehydrogenase family
GC089_RS13430	COG1454	alcohol dehydrogenase
GC089_RS13450	COG2814	Major facilitator Superfamily
GC089_RS13465	COG2135	peptidase activity
GC089_RS13485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GC089_RS13510	COG1742	UPF0060 membrane protein
GC089_RS13515	COG0424	maF-like protein
GC089_RS13520	COG4770	biotin carboxylase activity
GC089_RS13540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GC089_RS13565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GC089_RS13590	COG4603	Belongs to the binding-protein-dependent transport system permease family
GC089_RS13595	COG3845	ABC transporter
GC089_RS13600	COG1744	ABC transporter substrate-binding protein PnrA-like
GC089_RS13605	COG1473	amidohydrolase
GC089_RS13605	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GC089_RS13610	COG0662	Cupin 2, conserved barrel domain protein
GC089_RS13610	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GC089_RS13615	COG2009	succinate dehydrogenase
GC089_RS13625	COG1053	succinate dehydrogenase
GC089_RS13630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GC089_RS13650	COG0180	Tryptophanyl-tRNA synthetase
GC089_RS13655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GC089_RS13660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GC089_RS13670	COG1595	DNA-templated transcription, initiation
GC089_RS13675	COG4122	O-methyltransferase activity
GC089_RS13680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GC089_RS13695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GC089_RS13700	COG1611	Belongs to the LOG family
GC089_RS13705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GC089_RS13740	COG2720	vancomycin resistance protein
GC089_RS13765	COG1217	gtp-binding protein TYPA
GC089_RS13785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GC089_RS13790	COG0601	transmembrane transport
GC089_RS13795	COG0747	negative chemotaxis
GC089_RS13800	COG0012	GTP binding
GC089_RS13815	COG1322	Protein conserved in bacteria
GC089_RS13825	COG1570	exodeoxyribonuclease VII activity
GC089_RS13830	COG1722	exodeoxyribonuclease VII activity
GC089_RS13840	COG0288	reversible hydration of carbon dioxide
GC089_RS13870	COG0114	fumarate hydratase activity
GC089_RS13890	COG1136	(ABC) transporter
GC089_RS13890	COG0577	efflux transmembrane transporter activity
GC089_RS13895	COG0577	efflux transmembrane transporter activity
GC089_RS13895	COG1136	(ABC) transporter
GC089_RS13900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GC089_RS13905	COG1121	(ABC) transporter
GC089_RS13915	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GC089_RS13920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GC089_RS13930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GC089_RS13940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GC089_RS13950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GC089_RS13955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GC089_RS13970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GC089_RS13975	COG1793	dna ligase
GC089_RS13990	COG0277	FAD linked oxidase domain protein
GC089_RS13995	COG1794	racemase activity, acting on amino acids and derivatives
GC089_RS14015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GC089_RS14025	COG3458	cephalosporin-C deacetylase activity
GC089_RS14040	COG1131	(ABC) transporter
GC089_RS14050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GC089_RS14060	COG4604	ABC transporter, ATP-binding protein
GC089_RS14065	COG4605	iron ion homeostasis
GC089_RS14070	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GC089_RS14075	COG4607	ABC-type enterochelin transport system periplasmic component
GC089_RS14090	COG1252	NADH dehydrogenase
GC089_RS14095	COG1253	flavin adenine dinucleotide binding
GC089_RS14125	COG0148	phosphopyruvate hydratase activity
GC089_RS14130	COG2890	protein-(glutamine-N5) methyltransferase activity
GC089_RS14145	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GC089_RS14170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GC089_RS14175	COG1132	(ABC) transporter
GC089_RS14210	COG0438	transferase activity, transferring glycosyl groups
GC089_RS14255	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GC089_RS14265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GC089_RS14280	COG1309	transcriptional regulator
GC089_RS14285	COG1846	Transcriptional regulator
GC089_RS14290	COG2807	transmembrane transport
GC089_RS14295	COG0640	Transcriptional regulator
GC089_RS14300	COG0488	(ABC) transporter
GC089_RS14315	COG4152	abc transporter atp-binding protein
GC089_RS14320	COG2197	response regulator
GC089_RS14330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GC089_RS14335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GC089_RS14345	COG3583	domain protein
GC089_RS14355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GC089_RS14370	COG1335	isochorismatase
GC089_RS14415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GC089_RS14435	COG1970	mechanosensitive ion channel activity
GC089_RS14470	COG0384	phenazine biosynthesis protein PhzF
GC089_RS14505	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GC089_RS14565	COG1863	multisubunit Na H antiporter MnhE subunit
GC089_RS14570	COG0651	ATP synthesis coupled electron transport
GC089_RS14575	COG1006	Multisubunit Na H antiporter MnhC subunit
GC089_RS14585	COG3387	PFAM Glycoside hydrolase 15-related
GC089_RS14625	COG0243	molybdopterin cofactor binding
GC089_RS14640	COG0366	Alpha amylase catalytic
GC089_RS14645	COG0395	ABC-type sugar transport system, permease component
GC089_RS14650	COG1175	transmembrane transport
GC089_RS14660	COG1609	Transcriptional regulator
GC089_RS14665	COG1309	transcriptional regulator
GC089_RS14670	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS14680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GC089_RS14685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GC089_RS14690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GC089_RS14695	COG3693	PFAM glycoside hydrolase, family 10
GC089_RS14700	COG0667	Aldo Keto reductase
GC089_RS14705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GC089_RS14715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GC089_RS14790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GC089_RS14810	COG3265	gluconokinase activity
GC089_RS14835	COG0667	Aldo Keto reductase
GC089_RS14845	COG1834	amidinotransferase
GC089_RS14850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GC089_RS14860	COG1522	sequence-specific DNA binding
GC089_RS14875	COG0791	NLP P60 protein
GC089_RS14900	COG2814	Major facilitator Superfamily
GC089_RS14915	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GC089_RS14930	COG2252	PERMEase
GC089_RS14940	COG2089	acid synthase
GC089_RS14950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GC089_RS14955	COG1086	Polysaccharide biosynthesis protein
GC089_RS14960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GC089_RS14965	COG3754	Rhamnan synthesis protein F
GC089_RS14990	COG0489	protein tyrosine kinase activity
GC089_RS15005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GC089_RS15025	COG1966	Carbon starvation protein
GC089_RS15040	COG1278	Cold shock
GC089_RS15050	COG1473	amidohydrolase
GC089_RS15060	COG1061	Type III restriction enzyme res subunit
GC089_RS15080	COG1842	Phage shock protein A
GC089_RS15090	COG0745	RESPONSE REGULATOR receiver
GC089_RS15095	COG2205	protein histidine kinase activity
GC089_RS15125	COG1802	Transcriptional regulator
GC089_RS15165	COG0745	RESPONSE REGULATOR receiver
GC089_RS15175	COG0745	RESPONSE REGULATOR receiver
GC089_RS15185	COG2201	protein-glutamate methylesterase activity
GC089_RS15215	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GC089_RS15220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GC089_RS15225	COG1684	flagellar biosynthetic protein fliR
GC089_RS15235	COG1338	Plays a role in the flagellum-specific transport system
GC089_RS15245	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GC089_RS15245	COG1776	CheC inhibitor of MCP methylation
GC089_RS15310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GC089_RS15320	COG1677	Flagellar hook-basal body complex protein FliE
GC089_RS15345	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GC089_RS15350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GC089_RS15360	COG0463	Glycosyl transferase, family 2
GC089_RS15360	COG0457	Tetratricopeptide repeat
GC089_RS15365	COG1191	sigma factor activity
GC089_RS15375	COG4786	Flagellar basal body rod
GC089_RS15375	COG1256	bacterial-type flagellum assembly
GC089_RS15385	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GC089_RS15400	COG0459	protein refolding
GC089_RS15405	COG1278	Cold shock
GC089_RS15420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GC089_RS15455	COG2197	response regulator
GC089_RS15490	COG0561	phosphatase activity
GC089_RS15490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GC089_RS15495	COG3842	ATPase activity
GC089_RS15520	COG0215	cysteine-tRNA ligase activity
GC089_RS15530	COG0604	alcohol dehydrogenase
GC089_RS15545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GC089_RS15550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GC089_RS15555	COG1329	Transcriptional regulator
GC089_RS15565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GC089_RS15580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GC089_RS15585	COG0745	RESPONSE REGULATOR receiver
GC089_RS15590	COG5002	protein histidine kinase activity
GC089_RS15600	COG0588	phosphoglycerate mutase activity
GC089_RS15615	COG0438	transferase activity, transferring glycosyl groups
GC089_RS15630	COG2115	Belongs to the xylose isomerase family
GC089_RS15635	COG1070	Carbohydrate kinase
GC089_RS15645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GC089_RS15660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GC089_RS15665	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GC089_RS15670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GC089_RS15695	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GC089_RS15700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GC089_RS15705	COG0302	gtp cyclohydrolase
GC089_RS15710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GC089_RS15715	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GC089_RS15720	COG0037	tRNA processing
GC089_RS15730	COG2027	D-alanyl-D-alanine carboxypeptidase
GC089_RS15735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GC089_RS15745	COG2873	o-acetylhomoserine
GC089_RS15750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GC089_RS15765	COG0604	alcohol dehydrogenase
GC089_RS15785	COG0477	Major facilitator Superfamily
GC089_RS15800	COG0247	lactate metabolic process
GC089_RS15800	COG0277	FAD linked oxidase domain protein
GC089_RS15815	COG1876	peptidase activity
GC089_RS15835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GC089_RS15870	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GC089_RS15870	COG1672	PFAM Archaeal ATPase
GC089_RS15900	COG3973	AAA domain
GC089_RS15920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GC089_RS15955	COG0395	ABC-type sugar transport system, permease component
GC089_RS15960	COG1175	transmembrane transport
GC089_RS15965	COG2182	Extracellular solute-binding protein
GC089_RS15975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GC089_RS15975	COG1754	DNA topoisomerase type I activity
GC089_RS15985	COG0406	alpha-ribazole phosphatase activity
GC089_RS16000	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GC089_RS16010	COG1194	a g-specific adenine glycosylase
GC089_RS16015	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GC089_RS16025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GC089_RS16030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GC089_RS16035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GC089_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS16105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GC089_RS16120	COG0058	SHG alpha-glucan phosphorylase activity
GC089_RS16130	COG0745	RESPONSE REGULATOR receiver
GC089_RS16150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GC089_RS16155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GC089_RS16170	COG1846	Transcriptional regulator
GC089_RS16190	COG0588	phosphoglycerate mutase activity
GC089_RS16225	COG1175	transmembrane transport
GC089_RS16235	COG1653	transport
GC089_RS16240	COG0584	glycerophosphoryl diester phosphodiesterase
GC089_RS16275	COG1472	Belongs to the glycosyl hydrolase 3 family
GC089_RS16280	COG1472	Belongs to the glycosyl hydrolase 3 family
GC089_RS16295	COG1247	-acetyltransferase
GC089_RS16335	COG1472	Belongs to the glycosyl hydrolase 3 family
GC089_RS16360	COG1609	Transcriptional regulator
GC089_RS16395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GC089_RS16430	COG2267	carboxylic ester hydrolase activity
GC089_RS16435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GC089_RS16440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GC089_RS16445	COG1780	Probably involved in ribonucleotide reductase function
GC089_RS16460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GC089_RS16465	COG0789	Transcriptional regulator
GC089_RS16470	COG0484	heat shock protein binding
GC089_RS16475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GC089_RS16480	COG0443	Heat shock 70 kDa protein
GC089_RS16505	COG4585	Histidine kinase
GC089_RS16505	COG2203	Gaf domain
GC089_RS16555	COG2197	response regulator
GC089_RS16625	COG2267	carboxylic ester hydrolase activity
GC089_RS16655	COG3708	Transcriptional regulator
GC089_RS16655	COG2207	Transcriptional regulator
GC089_RS16675	COG3135	benzoate transporter
GC089_RS16740	COG3655	Transcriptional regulator
GC089_RS16795	COG2226	methyltransferase
GC089_RS16815	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS16840	COG1366	Belongs to the anti-sigma-factor antagonist family
GC089_RS16855	COG0693	protein deglycase activity
GC089_RS16865	COG3795	YCII-related domain
GC089_RS16905	COG3842	ATPase activity
GC089_RS16910	COG4149	molybdate abc transporter
GC089_RS16925	COG0659	secondary active sulfate transmembrane transporter activity
GC089_RS16930	COG0789	Transcriptional regulator
GC089_RS16950	COG0651	ATP synthesis coupled electron transport
GC089_RS16955	COG1006	Multisubunit Na H antiporter MnhC subunit
GC089_RS16960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GC089_RS16960	COG2111	Na H antiporter
GC089_RS16975	COG2181	nitrate reductase activity
GC089_RS16975	COG0247	lactate metabolic process
GC089_RS16985	COG1120	ATPase activity
GC089_RS16990	COG4585	Histidine kinase
GC089_RS16995	COG2197	response regulator
GC089_RS17005	COG1595	DNA-templated transcription, initiation
GC089_RS17055	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GC089_RS17095	COG1132	(ABC) transporter
GC089_RS17115	COG1132	(ABC) transporter
GC089_RS17125	COG3387	PFAM Glycoside hydrolase 15-related
GC089_RS17130	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS17145	COG0717	Belongs to the dCTP deaminase family
GC089_RS17150	COG2211	Major facilitator Superfamily
GC089_RS17160	COG2909	trisaccharide binding
GC089_RS17160	COG2909	trisaccharide binding
GC089_RS17180	COG3459	Glycosyltransferase 36 associated
GC089_RS17195	COG0456	acetyltransferase
GC089_RS17210	COG1309	transcriptional regulator
GC089_RS17215	COG1131	(ABC) transporter
GC089_RS17220	COG3559	Exporter of polyketide antibiotics
GC089_RS17240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GC089_RS17245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GC089_RS17250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GC089_RS17255	COG0254	rRNA binding
GC089_RS17260	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GC089_RS17375	COG0823	Involved in the tonB-independent uptake of proteins
GC089_RS17375	COG1506	peptidase
GC089_RS17380	COG1028	Short-chain dehydrogenase reductase Sdr
GC089_RS17435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GC089_RS17440	COG1950	PFAM Membrane protein of
GC089_RS17465	COG0714	Associated with various cellular activities
GC089_RS17500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GC089_RS17510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GC089_RS17515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GC089_RS17525	COG0181	hydroxymethylbilane synthase activity
GC089_RS17540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GC089_RS17545	COG0730	response to heat
GC089_RS17555	COG1937	Protein conserved in bacteria
GC089_RS17585	COG1131	(ABC) transporter
GC089_RS17635	COG4251	negative regulation of phosphorylation
GC089_RS17655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GC089_RS17670	COG0710	3-dehydroquinate dehydratase activity
GC089_RS17675	COG0628	permease
GC089_RS17685	COG0697	spore germination
GC089_RS17720	COG0205	6-phosphofructokinase activity
GC089_RS17735	COG0366	Alpha amylase catalytic
GC089_RS17790	COG1280	lysine exporter protein (LysE YggA)
GC089_RS17825	COG0789	Transcriptional regulator
GC089_RS17830	COG1113	amino acid transport
GC089_RS17860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GC089_RS17865	COG0477	Major facilitator Superfamily
GC089_RS17905	COG3534	alpha-L-arabinofuranosidase
GC089_RS17915	COG1175	transmembrane transport
GC089_RS17920	COG1653	transport
GC089_RS17925	COG1609	Transcriptional regulator
GC089_RS17950	COG1472	Belongs to the glycosyl hydrolase 3 family
GC089_RS17975	COG0564	pseudouridine synthase activity
GC089_RS17980	COG3693	PFAM glycoside hydrolase, family 10
GC089_RS18005	COG0702	epimerase
GC089_RS18010	COG1733	regulation of RNA biosynthetic process
GC089_RS18025	COG0596	Alpha beta hydrolase
GC089_RS18065	COG0513	Belongs to the DEAD box helicase family
GC089_RS18100	COG0305	Participates in initiation and elongation during chromosome replication
GC089_RS18105	COG0534	Mate efflux family protein
GC089_RS18120	COG0359	binds to the 23S rRNA
GC089_RS18125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GC089_RS18135	COG0360	Binds together with S18 to 16S ribosomal RNA
GC089_RS18140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GC089_RS18150	COG1260	myo-inositol-1-phosphate synthase
GC089_RS18170	COG1595	DNA-templated transcription, initiation
GC089_RS18210	COG0617	tRNA 3'-terminal CCA addition
GC089_RS18240	COG0492	ferredoxin-NADP+ reductase activity
GC089_RS18245	COG3118	belongs to the thioredoxin family
GC089_RS18255	COG1192	Involved in chromosome partitioning
GC089_RS18260	COG0357	Ribosomal RNA small subunit methyltransferase G
GC089_RS18265	COG0706	membrane insertase activity
GC089_RS18270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GC089_RS18275	COG0594	ribonuclease P activity
GC089_RS18280	COG0230	Belongs to the bacterial ribosomal protein bL34 family