locus-tag	class	description
HKK73_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HKK73_RS00010	COG0592	DNA-directed DNA polymerase activity
HKK73_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HKK73_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HKK73_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HKK73_RS00035	COG0187	DNA topoisomerase II activity
HKK73_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKK73_RS00085	COG3764	Sortase (surface protein transpeptidase)
HKK73_RS00105	COG0515	serine threonine protein kinase
HKK73_RS00110	COG0768	penicillin binding
HKK73_RS00125	COG1716	ATPase activity
HKK73_RS00165	COG1120	ATPase activity
HKK73_RS00170	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK73_RS00205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKK73_RS00235	COG0436	Aminotransferase
HKK73_RS00255	COG0039	L-malate dehydrogenase activity
HKK73_RS00260	COG2204	response regulator
HKK73_RS00265	COG5002	protein histidine kinase activity
HKK73_RS00275	COG1215	transferase activity, transferring glycosyl groups
HKK73_RS00285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HKK73_RS00285	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HKK73_RS00290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HKK73_RS00295	COG0509	glycine decarboxylation via glycine cleavage system
HKK73_RS00310	COG5002	protein histidine kinase activity
HKK73_RS00335	COG0494	nUDIX hydrolase
HKK73_RS00355	COG1473	amidohydrolase
HKK73_RS00365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HKK73_RS00370	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HKK73_RS00395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HKK73_RS00415	COG0318	PFAM AMP-dependent synthetase and ligase
HKK73_RS00425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKK73_RS00440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKK73_RS00550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HKK73_RS00560	COG1295	ribonuclease BN
HKK73_RS00565	COG0039	L-malate dehydrogenase activity
HKK73_RS00580	COG3119	arylsulfatase activity
HKK73_RS00610	COG0363	glucosamine-6-phosphate deaminase activity
HKK73_RS00615	COG0673	inositol 2-dehydrogenase activity
HKK73_RS00625	COG2186	Transcriptional regulator
HKK73_RS00630	COG0747	negative chemotaxis
HKK73_RS00635	COG0601	transmembrane transport
HKK73_RS00640	COG0444	Belongs to the ABC transporter superfamily
HKK73_RS00645	COG4608	Belongs to the ABC transporter superfamily
HKK73_RS00650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK73_RS00660	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HKK73_RS00700	COG2826	transposase and inactivated derivatives, IS30 family
HKK73_RS00745	COG2208	phosphoserine phosphatase activity
HKK73_RS00750	COG1215	transferase activity, transferring glycosyl groups
HKK73_RS00755	COG1366	Belongs to the anti-sigma-factor antagonist family
HKK73_RS00825	COG0789	Transcriptional regulator
HKK73_RS00830	COG1742	UPF0060 membrane protein
HKK73_RS00865	COG1960	acyl-CoA dehydrogenase activity
HKK73_RS00885	COG2382	esterase
HKK73_RS00890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKK73_RS00900	COG0640	Transcriptional regulator
HKK73_RS00905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HKK73_RS00910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKK73_RS00915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKK73_RS00920	COG0798	PFAM Bile acid sodium symporter
HKK73_RS00935	COG2197	response regulator
HKK73_RS00990	COG1595	DNA-templated transcription, initiation
HKK73_RS01000	COG0588	phosphoglycerate mutase activity
HKK73_RS01005	COG2197	response regulator
HKK73_RS01030	COG3250	beta-galactosidase activity
HKK73_RS01040	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HKK73_RS01055	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HKK73_RS01070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS01075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HKK73_RS01080	COG0586	Pfam SNARE associated Golgi protein
HKK73_RS01090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HKK73_RS01130	COG1823	symporter activity
HKK73_RS01140	COG2197	response regulator
HKK73_RS01145	COG4585	Histidine kinase
HKK73_RS01180	COG0076	glutamate decarboxylase activity
HKK73_RS01185	COG0531	amino acid
HKK73_RS01190	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HKK73_RS01190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HKK73_RS01205	COG0531	amino acid
HKK73_RS01210	COG1228	amidohydrolase
HKK73_RS01215	COG1278	Cold shock
HKK73_RS01250	COG1276	copper resistance
HKK73_RS01270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HKK73_RS01275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HKK73_RS01280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HKK73_RS01285	COG0254	rRNA binding
HKK73_RS01290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HKK73_RS01365	COG1472	Belongs to the glycosyl hydrolase 3 family
HKK73_RS01375	COG1216	Glycosyl transferase, family 2
HKK73_RS01390	COG0022	dehydrogenase e1 component
HKK73_RS01395	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKK73_RS01400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKK73_RS01410	COG1960	acyl-CoA dehydrogenase activity
HKK73_RS01430	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HKK73_RS01435	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HKK73_RS01445	COG1192	Involved in chromosome partitioning
HKK73_RS01465	COG0601	transmembrane transport
HKK73_RS01470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKK73_RS01505	COG1131	(ABC) transporter
HKK73_RS01525	COG1937	Protein conserved in bacteria
HKK73_RS01550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HKK73_RS01555	COG0113	porphobilinogen synthase activity
HKK73_RS01565	COG0181	hydroxymethylbilane synthase activity
HKK73_RS01575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HKK73_RS01580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HKK73_RS01585	COG3537	Alpha-1,2-mannosidase
HKK73_RS01590	COG0248	Ppx GppA phosphatase
HKK73_RS01595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK73_RS01600	COG0739	heme binding
HKK73_RS01610	COG0494	nUDIX hydrolase
HKK73_RS01615	COG1649	PFAM Uncharacterised BCR, COG1649
HKK73_RS01635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKK73_RS01650	COG1950	PFAM Membrane protein of
HKK73_RS01655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HKK73_RS01685	COG0022	dehydrogenase e1 component
HKK73_RS01690	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKK73_RS01705	COG2223	nitrite transmembrane transporter activity
HKK73_RS01715	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKK73_RS01720	COG2146	nitrite reductase [NAD(P)H] activity
HKK73_RS01720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKK73_RS01725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKK73_RS01725	COG2146	nitrite reductase [NAD(P)H] activity
HKK73_RS01730	COG1648	precorrin-2 dehydrogenase activity
HKK73_RS01730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HKK73_RS01795	COG0714	Associated with various cellular activities
HKK73_RS01800	COG3467	pyridoxamine 5'-phosphate
HKK73_RS01815	COG1506	peptidase
HKK73_RS01815	COG0823	Involved in the tonB-independent uptake of proteins
HKK73_RS01840	COG1309	transcriptional regulator
HKK73_RS01845	COG2409	Drug exporters of the RND superfamily
HKK73_RS01875	COG2608	mercury ion transmembrane transporter activity
HKK73_RS01900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK73_RS01900	COG2190	(PTS) system
HKK73_RS01900	COG1263	PTS System
HKK73_RS01905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK73_RS01910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK73_RS01915	COG2188	Transcriptional regulator
HKK73_RS01920	COG1263	PTS System
HKK73_RS01925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKK73_RS01930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKK73_RS01935	COG1082	Xylose isomerase domain protein TIM barrel
HKK73_RS01950	COG0477	Major facilitator Superfamily
HKK73_RS01965	COG2197	response regulator
HKK73_RS01970	COG4585	Histidine kinase
HKK73_RS01990	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HKK73_RS02000	COG0028	Belongs to the TPP enzyme family
HKK73_RS02005	COG3634	alkyl hydroperoxide reductase activity
HKK73_RS02035	COG1053	succinate dehydrogenase
HKK73_RS02090	COG2318	DinB family
HKK73_RS02105	COG1215	transferase activity, transferring glycosyl groups
HKK73_RS02125	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HKK73_RS02130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK73_RS02175	COG1215	transferase activity, transferring glycosyl groups
HKK73_RS02195	COG0477	Major facilitator Superfamily
HKK73_RS02210	COG4948	Mandelate Racemase Muconate Lactonizing
HKK73_RS02215	COG1802	Transcriptional regulator
HKK73_RS02235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HKK73_RS02255	COG1609	Transcriptional regulator
HKK73_RS02260	COG1653	transport
HKK73_RS02265	COG1175	transmembrane transport
HKK73_RS02270	COG0395	ABC-type sugar transport system, permease component
HKK73_RS02270	COG0395	ABC-type sugar transport system, permease component
HKK73_RS02275	COG5006	permease, DMT superfamily
HKK73_RS02285	COG0604	alcohol dehydrogenase
HKK73_RS02285	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS02285	COG3321	synthase
HKK73_RS02295	COG2018	Roadblock/LC7 domain
HKK73_RS02335	COG1136	(ABC) transporter
HKK73_RS02345	COG1309	transcriptional regulator
HKK73_RS02350	COG2267	carboxylic ester hydrolase activity
HKK73_RS02375	COG0395	ABC-type sugar transport system, permease component
HKK73_RS02380	COG1175	transmembrane transport
HKK73_RS02390	COG1940	carbohydrate kinase activity
HKK73_RS02395	COG4213	ABC transporter substrate-binding protein
HKK73_RS02405	COG4214	carbohydrate transport
HKK73_RS02410	COG1609	Transcriptional regulator
HKK73_RS02440	COG0717	Belongs to the dCTP deaminase family
HKK73_RS02450	COG2111	Na H antiporter
HKK73_RS02450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HKK73_RS02485	COG2340	Cysteine-rich secretory protein family
HKK73_RS02495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKK73_RS02495	COG2169	Transcriptional regulator
HKK73_RS02525	COG1597	lipid kinase activity
HKK73_RS02530	COG1573	uracil-dna glycosylase
HKK73_RS02540	COG2197	response regulator
HKK73_RS02545	COG4585	Histidine kinase
HKK73_RS02555	COG1131	(ABC) transporter
HKK73_RS02565	COG1309	transcriptional regulator
HKK73_RS02595	COG4565	transcriptional regulatory protein
HKK73_RS02600	COG3290	protein histidine kinase activity
HKK73_RS02620	COG0589	response to stress
HKK73_RS02625	COG4221	oxidoreductase activity
HKK73_RS02630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HKK73_RS02680	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HKK73_RS02685	COG0151	Belongs to the GarS family
HKK73_RS02695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKK73_RS02700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HKK73_RS02720	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKK73_RS02725	COG0047	phosphoribosylformylglycinamidine synthase activity
HKK73_RS02740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS02770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS02780	COG1074	ATP-dependent DNA helicase activity
HKK73_RS02790	COG2226	methyltransferase
HKK73_RS02805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKK73_RS02830	COG2030	dehydratase
HKK73_RS02865	COG1113	amino acid transport
HKK73_RS02870	COG0697	spore germination
HKK73_RS02875	COG0583	DNA-binding transcription factor activity
HKK73_RS02895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKK73_RS02905	COG2409	Drug exporters of the RND superfamily
HKK73_RS02915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS02920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS02940	COG1126	abc transporter atp-binding protein
HKK73_RS02945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK73_RS02950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK73_RS02955	COG0778	Nitroreductase
HKK73_RS02960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS02970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS02975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS02985	COG0747	negative chemotaxis
HKK73_RS02990	COG0601	transmembrane transport
HKK73_RS02995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKK73_RS03010	COG0667	Aldo Keto reductase
HKK73_RS03025	COG0431	NADPH-dependent FMN reductase
HKK73_RS03030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKK73_RS03045	COG1764	response to oxidative stress
HKK73_RS03055	COG3142	Participates in the control of copper homeostasis
HKK73_RS03060	COG0747	negative chemotaxis
HKK73_RS03065	COG0601	transmembrane transport
HKK73_RS03070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKK73_RS03075	COG0444	Belongs to the ABC transporter superfamily
HKK73_RS03080	COG4608	Belongs to the ABC transporter superfamily
HKK73_RS03085	COG0557	exoribonuclease II activity
HKK73_RS03095	COG4085	toxin activity
HKK73_RS03095	COG1525	nuclease
HKK73_RS03095	COG0737	Belongs to the 5'-nucleotidase family
HKK73_RS03105	COG3842	ATPase activity
HKK73_RS03110	COG4208	sulfate ABC transporter
HKK73_RS03130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HKK73_RS03185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKK73_RS03250	COG0584	glycerophosphoryl diester phosphodiesterase
HKK73_RS03260	COG1063	alcohol dehydrogenase
HKK73_RS03275	COG2226	methyltransferase
HKK73_RS03290	COG2318	DinB family
HKK73_RS03295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKK73_RS03340	COG0513	Belongs to the DEAD box helicase family
HKK73_RS03345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKK73_RS03375	COG0477	Major facilitator Superfamily
HKK73_RS03390	COG0306	phosphate transporter
HKK73_RS03400	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HKK73_RS03405	COG0456	acetyltransferase
HKK73_RS03420	COG0477	Major facilitator Superfamily
HKK73_RS03425	COG1357	PFAM Pentapeptide repeats (8 copies)
HKK73_RS03430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKK73_RS03505	COG1111	helicase
HKK73_RS03505	COG1205	dead DEAH box helicase
HKK73_RS03515	COG1362	aminopeptidase activity
HKK73_RS03525	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HKK73_RS03530	COG1472	Belongs to the glycosyl hydrolase 3 family
HKK73_RS03575	COG4942	peptidase
HKK73_RS03585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HKK73_RS03600	COG1754	DNA topoisomerase type I activity
HKK73_RS03600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKK73_RS03605	COG0371	Dehydrogenase
HKK73_RS03615	COG1695	Transcriptional regulator
HKK73_RS03630	COG0577	efflux transmembrane transporter activity
HKK73_RS03630	COG1136	(ABC) transporter
HKK73_RS03635	COG1136	(ABC) transporter
HKK73_RS03640	COG0673	inositol 2-dehydrogenase activity
HKK73_RS03650	COG1846	Transcriptional regulator
HKK73_RS03655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKK73_RS03660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HKK73_RS03670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS03715	COG2217	Heavy metal translocating P-type atpase
HKK73_RS03755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKK73_RS03770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS03775	COG2890	protein-(glutamine-N5) methyltransferase activity
HKK73_RS03795	COG1556	Lactate utilization protein
HKK73_RS03800	COG1139	Iron-sulfur cluster binding protein
HKK73_RS03805	COG0247	lactate metabolic process
HKK73_RS03810	COG2186	Transcriptional regulator
HKK73_RS03815	COG4941	Belongs to the sigma-70 factor family
HKK73_RS03835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKK73_RS03845	COG0667	Aldo Keto reductase
HKK73_RS03850	COG4941	Belongs to the sigma-70 factor family
HKK73_RS03860	COG4608	Belongs to the ABC transporter superfamily
HKK73_RS03865	COG4251	negative regulation of phosphorylation
HKK73_RS03895	COG0395	ABC-type sugar transport system, permease component
HKK73_RS03905	COG1609	Transcriptional regulator
HKK73_RS03915	COG1846	Transcriptional regulator
HKK73_RS03915	COG1940	carbohydrate kinase activity
HKK73_RS03920	COG2115	Belongs to the xylose isomerase family
HKK73_RS03925	COG1070	Carbohydrate kinase
HKK73_RS03930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HKK73_RS03935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HKK73_RS03950	COG0395	ABC-type sugar transport system, permease component
HKK73_RS03955	COG1175	transmembrane transport
HKK73_RS03990	COG1802	Transcriptional regulator
HKK73_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS04010	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS04040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKK73_RS04050	COG3386	PFAM SMP-30 Gluconolaconase
HKK73_RS04055	COG0180	Tryptophanyl-tRNA synthetase
HKK73_RS04070	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HKK73_RS04075	COG1396	sequence-specific DNA binding
HKK73_RS04095	COG2198	Histidine kinase
HKK73_RS04095	COG0784	Response regulator, receiver
HKK73_RS04095	COG0643	Histidine kinase
HKK73_RS04115	COG2201	protein-glutamate methylesterase activity
HKK73_RS04120	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HKK73_RS04125	COG0745	RESPONSE REGULATOR receiver
HKK73_RS04135	COG0745	RESPONSE REGULATOR receiver
HKK73_RS04155	COG4786	Flagellar basal body rod
HKK73_RS04155	COG1256	bacterial-type flagellum assembly
HKK73_RS04165	COG1191	sigma factor activity
HKK73_RS04170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HKK73_RS04175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HKK73_RS04180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HKK73_RS04200	COG1815	bacterial-type flagellum-dependent cell motility
HKK73_RS04210	COG1677	Flagellar hook-basal body complex protein FliE
HKK73_RS04215	COG1766	The M ring may be actively involved in energy transduction
HKK73_RS04230	COG1157	protein secretion by the type III secretion system
HKK73_RS04290	COG1338	Plays a role in the flagellum-specific transport system
HKK73_RS04295	COG1987	bacterial-type flagellum assembly
HKK73_RS04305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HKK73_RS04310	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HKK73_RS04320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HKK73_RS04340	COG2909	trisaccharide binding
HKK73_RS04340	COG2909	trisaccharide binding
HKK73_RS04360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HKK73_RS04365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HKK73_RS04370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HKK73_RS04380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HKK73_RS04385	COG1194	a g-specific adenine glycosylase
HKK73_RS04395	COG2226	methyltransferase
HKK73_RS04400	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HKK73_RS04405	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HKK73_RS04410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKK73_RS04420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HKK73_RS04425	COG1609	Transcriptional regulator
HKK73_RS04440	COG2160	L-arabinose isomerase activity
HKK73_RS04445	COG1879	ABC-type sugar transport system periplasmic component
HKK73_RS04455	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK73_RS04460	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK73_RS04475	COG3507	Belongs to the glycosyl hydrolase 43 family
HKK73_RS04480	COG3507	Belongs to the glycosyl hydrolase 43 family
HKK73_RS04485	COG3507	Belongs to the glycosyl hydrolase 43 family
HKK73_RS04510	COG0569	domain protein
HKK73_RS04515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HKK73_RS04520	COG0123	including yeast histone deacetylase and acetoin utilization protein
HKK73_RS04540	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HKK73_RS04555	COG0406	alpha-ribazole phosphatase activity
HKK73_RS04565	COG0785	Cytochrome C biogenesis protein
HKK73_RS04570	COG1333	cytochrome c biogenesis protein
HKK73_RS04575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HKK73_RS04590	COG1575	Belongs to the MenA family. Type 1 subfamily
HKK73_RS04600	COG1470	cell adhesion involved in biofilm formation
HKK73_RS04610	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HKK73_RS04620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK73_RS04635	COG4948	Mandelate Racemase Muconate Lactonizing
HKK73_RS04640	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HKK73_RS04645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKK73_RS04655	COG2226	methyltransferase
HKK73_RS04670	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKK73_RS04680	COG0649	NAD binding
HKK73_RS04690	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HKK73_RS04695	COG1034	ATP synthesis coupled electron transport
HKK73_RS04700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HKK73_RS04705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKK73_RS04715	COG0713	ATP synthesis coupled electron transport
HKK73_RS04720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HKK73_RS04730	COG1007	ATP synthesis coupled electron transport
HKK73_RS04745	COG0714	Associated with various cellular activities
HKK73_RS04760	COG1716	ATPase activity
HKK73_RS04765	COG0631	protein serine/threonine phosphatase activity
HKK73_RS04785	COG1674	ftsk spoiiie
HKK73_RS04805	COG0501	Belongs to the peptidase M48B family
HKK73_RS04810	COG0561	phosphatase activity
HKK73_RS04815	COG1666	GTP binding
HKK73_RS04840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HKK73_RS04845	COG2030	dehydratase
HKK73_RS04850	COG2030	dehydratase
HKK73_RS04860	COG1609	Transcriptional regulator
HKK73_RS04870	COG0738	Major facilitator superfamily
HKK73_RS04875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HKK73_RS04885	COG1725	Transcriptional regulator
HKK73_RS04905	COG0745	RESPONSE REGULATOR receiver
HKK73_RS04920	COG4106	trans-aconitate 2-methyltransferase activity
HKK73_RS04925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKK73_RS04930	COG2197	response regulator
HKK73_RS04935	COG4585	Histidine kinase
HKK73_RS04935	COG2203	Gaf domain
HKK73_RS04945	COG1131	(ABC) transporter
HKK73_RS04965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HKK73_RS04970	COG0081	regulation of translation
HKK73_RS05010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HKK73_RS05015	COG0222	ribosome binding
HKK73_RS05020	COG0085	RNA polymerase activity
HKK73_RS05025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HKK73_RS05030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HKK73_RS05035	COG0049	tRNA binding
HKK73_RS05040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HKK73_RS05045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HKK73_RS05050	COG0051	transcription antitermination factor activity, RNA binding
HKK73_RS05055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HKK73_RS05060	COG0088	Forms part of the polypeptide exit tunnel
HKK73_RS05065	COG0089	rRNA binding
HKK73_RS05070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HKK73_RS05075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HKK73_RS05080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HKK73_RS05085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HKK73_RS05090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HKK73_RS05095	COG0255	Belongs to the universal ribosomal protein uL29 family
HKK73_RS05100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HKK73_RS05105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HKK73_RS05110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HKK73_RS05115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HKK73_RS05120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HKK73_RS05125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HKK73_RS05130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HKK73_RS05135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HKK73_RS05140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HKK73_RS05150	COG0200	Binds to the 23S rRNA
HKK73_RS05155	COG0201	protein transport
HKK73_RS05160	COG0563	adenylate kinase activity
HKK73_RS05170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HKK73_RS05175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HKK73_RS05180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HKK73_RS05185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HKK73_RS05190	COG0202	RNA polymerase activity
HKK73_RS05195	COG0203	ribosomal protein L17
HKK73_RS05205	COG1940	carbohydrate kinase activity
HKK73_RS05210	COG0101	tRNA pseudouridine synthase activity
HKK73_RS05225	COG0488	(ABC) transporter
HKK73_RS05235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HKK73_RS05240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HKK73_RS05250	COG0242	peptide deformylase activity
HKK73_RS05260	COG1072	(Pantothenic acid kinase))
HKK73_RS05275	COG0736	holo-[acyl-carrier-protein] synthase activity
HKK73_RS05295	COG0564	pseudouridine synthase activity
HKK73_RS05300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HKK73_RS05305	COG0802	atpase or kinase
HKK73_RS05325	COG0778	Nitroreductase
HKK73_RS05330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HKK73_RS05335	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HKK73_RS05345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HKK73_RS05375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKK73_RS05385	COG0516	GMP reductase activity
HKK73_RS05400	COG1012	belongs to the aldehyde dehydrogenase family
HKK73_RS05415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HKK73_RS05425	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HKK73_RS05445	COG1132	(ABC) transporter
HKK73_RS05450	COG1132	(ABC) transporter
HKK73_RS05465	COG2022	thiamine diphosphate biosynthetic process
HKK73_RS05475	COG2022	thiamine diphosphate biosynthetic process
HKK73_RS05475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKK73_RS05480	COG0352	thiamine-phosphate diphosphorylase activity
HKK73_RS05485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HKK73_RS05485	COG0519	Catalyzes the synthesis of GMP from XMP
HKK73_RS05515	COG2197	response regulator
HKK73_RS05520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HKK73_RS05520	COG1648	precorrin-2 dehydrogenase activity
HKK73_RS05540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKK73_RS05555	COG0596	Alpha beta hydrolase
HKK73_RS05575	COG0542	response to heat
HKK73_RS05585	COG0045	succinate-CoA ligase (ADP-forming) activity
HKK73_RS05625	COG0138	bifunctional purine biosynthesis protein purh
HKK73_RS05630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKK73_RS05650	COG0039	L-malate dehydrogenase activity
HKK73_RS05675	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK73_RS05695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HKK73_RS05700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HKK73_RS05710	COG0708	Exodeoxyribonuclease III
HKK73_RS05715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HKK73_RS05725	COG0577	efflux transmembrane transporter activity
HKK73_RS05725	COG1136	(ABC) transporter
HKK73_RS05730	COG1136	(ABC) transporter
HKK73_RS05730	COG0577	efflux transmembrane transporter activity
HKK73_RS05740	COG2151	metal-sulfur cluster biosynthetic enzyme
HKK73_RS05740	COG0489	protein tyrosine kinase activity
HKK73_RS05755	COG2239	Acts as a magnesium transporter
HKK73_RS05765	COG0006	proline dipeptidase activity
HKK73_RS05775	COG0613	PHP domain protein
HKK73_RS05780	COG2095	MarC family integral membrane protein
HKK73_RS05790	COG2186	Transcriptional regulator
HKK73_RS05795	COG2807	transmembrane transport
HKK73_RS05800	COG0513	Belongs to the DEAD box helicase family
HKK73_RS05885	COG3480	Lon protease (S16) C-terminal proteolytic domain
HKK73_RS05895	COG1615	UPF0182 protein
HKK73_RS05915	COG0765	amino acid transport
HKK73_RS05925	COG0515	serine threonine protein kinase
HKK73_RS05925	COG2815	serine threonine protein kinase
HKK73_RS05930	COG1331	Highly conserved protein containing a thioredoxin domain
HKK73_RS05940	COG1254	Belongs to the acylphosphatase family
HKK73_RS05955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKK73_RS05955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HKK73_RS05960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HKK73_RS05965	COG0590	tRNA wobble adenosine to inosine editing
HKK73_RS05970	COG2252	PERMEase
HKK73_RS05990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HKK73_RS05995	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HKK73_RS05995	COG3608	succinylglutamate desuccinylase aspartoacylase
HKK73_RS06005	COG2080	2 iron, 2 sulfur cluster binding
HKK73_RS06005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKK73_RS06015	COG4260	virion core protein, lumpy skin disease virus
HKK73_RS06025	COG1733	regulation of RNA biosynthetic process
HKK73_RS06030	COG0702	epimerase
HKK73_RS06035	COG0589	response to stress
HKK73_RS06040	COG1414	Transcriptional regulator
HKK73_RS06045	COG0800	Aldolase
HKK73_RS06050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK73_RS06065	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS06090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKK73_RS06105	COG1012	belongs to the aldehyde dehydrogenase family
HKK73_RS06130	COG1733	regulation of RNA biosynthetic process
HKK73_RS06160	COG0183	Belongs to the thiolase family
HKK73_RS06165	COG2267	carboxylic ester hydrolase activity
HKK73_RS06185	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS06195	COG0318	PFAM AMP-dependent synthetase and ligase
HKK73_RS06230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HKK73_RS06255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HKK73_RS06270	COG0114	fumarate hydratase activity
HKK73_RS06305	COG1722	exodeoxyribonuclease VII activity
HKK73_RS06310	COG1570	exodeoxyribonuclease VII activity
HKK73_RS06320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HKK73_RS06325	COG1322	Protein conserved in bacteria
HKK73_RS06340	COG0012	GTP binding
HKK73_RS06350	COG0601	transmembrane transport
HKK73_RS06355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKK73_RS06380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HKK73_RS06405	COG0287	Prephenate dehydrogenase
HKK73_RS06440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKK73_RS06445	COG1611	Belongs to the LOG family
HKK73_RS06450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKK73_RS06465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HKK73_RS06470	COG4122	O-methyltransferase activity
HKK73_RS06475	COG1595	DNA-templated transcription, initiation
HKK73_RS06485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKK73_RS06495	COG0180	Tryptophanyl-tRNA synthetase
HKK73_RS06510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HKK73_RS06515	COG1053	succinate dehydrogenase
HKK73_RS06525	COG2009	succinate dehydrogenase
HKK73_RS06535	COG1473	amidohydrolase
HKK73_RS06535	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HKK73_RS06570	COG2149	membrane
HKK73_RS06590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKK73_RS06595	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HKK73_RS06600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKK73_RS06615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HKK73_RS06640	COG4770	biotin carboxylase activity
HKK73_RS06645	COG0424	maF-like protein
HKK73_RS06650	COG0679	Auxin Efflux Carrier
HKK73_RS06675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKK73_RS06690	COG2135	peptidase activity
HKK73_RS06695	COG2814	Major facilitator Superfamily
HKK73_RS06700	COG1316	TRANSCRIPTIONal
HKK73_RS06850	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HKK73_RS06855	COG2884	Cell division ATP-binding protein ftsE
HKK73_RS06860	COG2177	Part of the ABC transporter FtsEX involved in
HKK73_RS06865	COG4942	peptidase
HKK73_RS06870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HKK73_RS06900	COG1846	Transcriptional regulator
HKK73_RS06900	COG1940	carbohydrate kinase activity
HKK73_RS06910	COG1175	transmembrane transport
HKK73_RS06915	COG0395	ABC-type sugar transport system, permease component
HKK73_RS06920	COG1940	carbohydrate kinase activity
HKK73_RS06925	COG0363	glucosamine-6-phosphate deaminase activity
HKK73_RS06945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HKK73_RS06955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HKK73_RS06960	COG1234	tRNA 3'-trailer cleavage
HKK73_RS06965	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HKK73_RS06970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HKK73_RS06980	COG0488	(ABC) transporter
HKK73_RS07010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HKK73_RS07040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HKK73_RS07045	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS07050	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HKK73_RS07055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HKK73_RS07065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKK73_RS07085	COG1732	Glycine betaine
HKK73_RS07090	COG1174	glycine betaine transport
HKK73_RS07095	COG1174	glycine betaine transport
HKK73_RS07100	COG1125	glycine betaine transport
HKK73_RS07100	COG0517	IMP dehydrogenase activity
HKK73_RS07105	COG1280	lysine exporter protein (LysE YggA)
HKK73_RS07115	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HKK73_RS07125	COG0671	phosphoesterase, PA-phosphatase related
HKK73_RS07140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HKK73_RS07145	COG1122	ATPase activity
HKK73_RS07150	COG0183	Belongs to the thiolase family
HKK73_RS07155	COG0318	PFAM AMP-dependent synthetase and ligase
HKK73_RS07160	COG1268	BioY protein
HKK73_RS07170	COG1716	ATPase activity
HKK73_RS07195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK73_RS07235	COG1160	GTP binding
HKK73_RS07245	COG0629	single-stranded DNA binding
HKK73_RS07275	COG0702	epimerase
HKK73_RS07285	COG1946	Acyl-CoA thioesterase
HKK73_RS07295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKK73_RS07300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HKK73_RS07305	COG0668	transmembrane transport
HKK73_RS07320	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HKK73_RS07330	COG3590	peptidase
HKK73_RS07335	COG0698	ribose 5-phosphate isomerase
HKK73_RS07345	COG4552	Acetyltransferase involved in intracellular survival and related
HKK73_RS07355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS07360	COG1045	serine acetyltransferase
HKK73_RS07385	COG0544	peptidyl-prolyl cis-trans isomerase activity
HKK73_RS07395	COG0740	serine-type endopeptidase activity
HKK73_RS07400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HKK73_RS07410	COG0287	Prephenate dehydrogenase
HKK73_RS07410	COG1605	Chorismate mutase
HKK73_RS07430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS07435	COG0778	Nitroreductase
HKK73_RS07435	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HKK73_RS07450	COG0628	permease
HKK73_RS07485	COG1832	CoA-binding protein
HKK73_RS07495	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HKK73_RS07500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKK73_RS07515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HKK73_RS07525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HKK73_RS07530	COG0285	dihydrofolate synthase activity
HKK73_RS07535	COG2376	Dihydroxyacetone kinase
HKK73_RS07540	COG1461	Dihydroxyacetone kinase
HKK73_RS07555	COG0477	Major facilitator Superfamily
HKK73_RS07565	COG0105	UTP biosynthetic process
HKK73_RS07595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HKK73_RS07610	COG0228	four-way junction DNA binding
HKK73_RS07615	COG1837	Belongs to the UPF0109 family
HKK73_RS07620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HKK73_RS07625	COG0336	Belongs to the RNA methyltransferase TrmD family
HKK73_RS07630	COG0335	large ribosomal subunit rRNA binding
HKK73_RS07635	COG0681	Belongs to the peptidase S26 family
HKK73_RS07640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKK73_RS07650	COG0792	nuclease activity
HKK73_RS07665	COG4974	Belongs to the 'phage' integrase family
HKK73_RS07675	COG0052	Belongs to the universal ribosomal protein uS2 family
HKK73_RS07680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HKK73_RS07690	COG0233	cytoplasmic translational termination
HKK73_RS07695	COG0575	Belongs to the CDS family
HKK73_RS07700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HKK73_RS07715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HKK73_RS07720	COG0750	zinc metalloprotease
HKK73_RS07725	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HKK73_RS07735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HKK73_RS07740	COG0442	prolyl-tRNA aminoacylation
HKK73_RS07750	COG0779	Required for maturation of 30S ribosomal subunits
HKK73_RS07765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HKK73_RS07770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HKK73_RS07775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HKK73_RS07795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKK73_RS07810	COG2197	response regulator
HKK73_RS07820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HKK73_RS07825	COG1185	polyribonucleotide nucleotidyltransferase activity
HKK73_RS07830	COG0612	Peptidase, M16
HKK73_RS07835	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HKK73_RS07880	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HKK73_RS07910	COG1674	ftsk spoiiie
HKK73_RS07920	COG1058	Belongs to the CinA family
HKK73_RS07920	COG1546	Belongs to the CinA family
HKK73_RS07925	COG1396	sequence-specific DNA binding
HKK73_RS07930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HKK73_RS07935	COG1201	RNA secondary structure unwinding
HKK73_RS07955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HKK73_RS07960	COG2137	regulation of response to DNA damage stimulus
HKK73_RS07965	COG0765	amino acid transport
HKK73_RS07970	COG0765	amino acid transport
HKK73_RS07975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK73_RS07980	COG1126	abc transporter atp-binding protein
HKK73_RS07985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HKK73_RS08010	COG0326	Molecular chaperone. Has ATPase activity
HKK73_RS08020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HKK73_RS08025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HKK73_RS08030	COG2813	Specifically methylates the guanine in position
HKK73_RS08035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HKK73_RS08050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HKK73_RS08060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HKK73_RS08065	COG0667	Aldo Keto reductase
HKK73_RS08080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKK73_RS08095	COG4251	negative regulation of phosphorylation
HKK73_RS08100	COG0784	Response regulator, receiver
HKK73_RS08110	COG1278	Cold shock
HKK73_RS08125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKK73_RS08145	COG0714	Associated with various cellular activities
HKK73_RS08150	COG2001	Belongs to the MraZ family
HKK73_RS08155	COG0275	rRNA processing
HKK73_RS08165	COG0768	penicillin binding
HKK73_RS08170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKK73_RS08180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HKK73_RS08185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HKK73_RS08195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HKK73_RS08200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HKK73_RS08210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HKK73_RS08220	COG1799	cell septum assembly
HKK73_RS08240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HKK73_RS08255	COG0587	DNA-directed DNA polymerase activity
HKK73_RS08270	COG2501	S4 domain
HKK73_RS08275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HKK73_RS08300	COG0131	Imidazoleglycerol-phosphate dehydratase
HKK73_RS08310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKK73_RS08315	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HKK73_RS08330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKK73_RS08355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HKK73_RS08360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HKK73_RS08365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HKK73_RS08370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKK73_RS08380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HKK73_RS08390	COG0300	oxidoreductase activity
HKK73_RS08400	COG0351	phosphomethylpyrimidine kinase
HKK73_RS08400	COG0352	thiamine-phosphate diphosphorylase activity
HKK73_RS08400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HKK73_RS08425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HKK73_RS08430	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HKK73_RS08435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HKK73_RS08440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HKK73_RS08445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKK73_RS08455	COG1438	arginine binding
HKK73_RS08460	COG0137	argininosuccinate synthase activity
HKK73_RS08465	COG0165	Argininosuccinate lyase
HKK73_RS08475	COG2094	Belongs to the DNA glycosylase MPG family
HKK73_RS08480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HKK73_RS08525	COG0497	DNA recombination
HKK73_RS08550	COG0504	CTP synthase activity
HKK73_RS08575	COG1131	(ABC) transporter
HKK73_RS08590	COG0719	Fe-S assembly protein
HKK73_RS08600	COG0396	ATPase activity
HKK73_RS08615	COG2151	metal-sulfur cluster biosynthetic enzyme
HKK73_RS08625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKK73_RS08630	COG2146	nitrite reductase [NAD(P)H] activity
HKK73_RS08630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKK73_RS08635	COG2318	DinB family
HKK73_RS08670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HKK73_RS08690	COG1435	thymidine kinase activity
HKK73_RS08700	COG2860	membrane
HKK73_RS08720	COG0756	dUTP diphosphatase activity
HKK73_RS08745	COG0569	domain protein
HKK73_RS08750	COG0531	amino acid
HKK73_RS08755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HKK73_RS08765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HKK73_RS08790	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HKK73_RS08800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HKK73_RS08805	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HKK73_RS08825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HKK73_RS08830	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKK73_RS08830	COG1024	Enoyl-CoA hydratase
HKK73_RS08845	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HKK73_RS08855	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HKK73_RS08890	COG2326	polyphosphate kinase activity
HKK73_RS08960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKK73_RS08960	COG0512	Glutamine amidotransferase of anthranilate synthase
HKK73_RS09000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HKK73_RS09010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKK73_RS09020	COG0438	transferase activity, transferring glycosyl groups
HKK73_RS09030	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HKK73_RS09035	COG1051	belongs to the nudix hydrolase family
HKK73_RS09045	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HKK73_RS09050	COG0217	transcriptional regulatory protein
HKK73_RS09055	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HKK73_RS09060	COG0632	four-way junction helicase activity
HKK73_RS09065	COG2255	four-way junction helicase activity
HKK73_RS09075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKK73_RS09080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKK73_RS09085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HKK73_RS09090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKK73_RS09095	COG1793	dna ligase
HKK73_RS09110	COG1196	nuclear chromosome segregation
HKK73_RS09120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKK73_RS09125	COG0124	histidyl-tRNA synthetase
HKK73_RS09140	COG3845	ABC transporter
HKK73_RS09145	COG4721	ABC-type cobalt transport system, permease component
HKK73_RS09165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HKK73_RS09180	COG0745	RESPONSE REGULATOR receiver
HKK73_RS09185	COG2409	Drug exporters of the RND superfamily
HKK73_RS09195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HKK73_RS09210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HKK73_RS09215	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HKK73_RS09225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HKK73_RS09235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HKK73_RS09240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HKK73_RS09245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HKK73_RS09255	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HKK73_RS09270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HKK73_RS09275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HKK73_RS09280	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HKK73_RS09285	COG0540	Belongs to the ATCase OTCase family
HKK73_RS09290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKK73_RS09300	COG0505	Belongs to the CarA family
HKK73_RS09305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HKK73_RS09310	COG0284	orotidine-5'-phosphate decarboxylase activity
HKK73_RS09320	COG0322	excinuclease ABC activity
HKK73_RS09325	COG0194	GDP metabolic process
HKK73_RS09330	COG1758	RNA polymerase activity
HKK73_RS09340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HKK73_RS09345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKK73_RS09360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HKK73_RS09385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HKK73_RS09400	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKK73_RS09400	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKK73_RS09405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HKK73_RS09410	COG0140	phosphoribosyl-ATP diphosphatase activity
HKK73_RS09415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HKK73_RS09450	COG1716	ATPase activity
HKK73_RS09470	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HKK73_RS09475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HKK73_RS09480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKK73_RS09550	COG0431	NADPH-dependent FMN reductase
HKK73_RS09555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS09565	COG1216	Glycosyl transferase, family 2
HKK73_RS09575	COG1228	amidohydrolase
HKK73_RS09585	COG1597	lipid kinase activity
HKK73_RS09590	COG0805	protein transport
HKK73_RS09595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HKK73_RS09610	COG2378	regulation of single-species biofilm formation
HKK73_RS09625	COG0714	Associated with various cellular activities
HKK73_RS09640	COG0783	Belongs to the Dps family
HKK73_RS09655	COG0137	argininosuccinate synthase activity
HKK73_RS09660	COG1739	Uncharacterized protein family UPF0029
HKK73_RS09675	COG0009	L-threonylcarbamoyladenylate synthase
HKK73_RS09685	COG0583	DNA-binding transcription factor activity
HKK73_RS09700	COG1755	Isoprenylcysteine carboxyl methyltransferase
HKK73_RS09735	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HKK73_RS09800	COG0583	DNA-binding transcription factor activity
HKK73_RS09805	COG0488	(ABC) transporter
HKK73_RS09815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKK73_RS09825	COG0789	Transcriptional regulator
HKK73_RS09835	COG1216	Glycosyl transferase, family 2
HKK73_RS09875	COG0596	Alpha beta hydrolase
HKK73_RS09900	COG2066	Belongs to the glutaminase family
HKK73_RS09975	COG0154	amidase activity
HKK73_RS09985	COG1160	GTP binding
HKK73_RS10005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HKK73_RS10020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HKK73_RS10025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HKK73_RS10040	COG0109	protoheme IX farnesyltransferase activity
HKK73_RS10050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKK73_RS10065	COG0363	glucosamine-6-phosphate deaminase activity
HKK73_RS10070	COG4122	O-methyltransferase activity
HKK73_RS10080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HKK73_RS10085	COG0149	triose-phosphate isomerase activity
HKK73_RS10090	COG0126	phosphoglycerate kinase activity
HKK73_RS10100	COG1481	regulation of sporulation
HKK73_RS10115	COG0322	excinuclease ABC activity
HKK73_RS10130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKK73_RS10150	COG0556	nucleotide-excision repair
HKK73_RS10160	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HKK73_RS10165	COG0237	dephospho-CoA kinase activity
HKK73_RS10165	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HKK73_RS10175	COG1132	(ABC) transporter
HKK73_RS10180	COG0539	negative regulation of cytoplasmic translation
HKK73_RS10200	COG2050	protein possibly involved in aromatic compounds catabolism
HKK73_RS10230	COG3541	Predicted nucleotidyltransferase
HKK73_RS10245	COG0069	glutamate synthase activity
HKK73_RS10245	COG0067	glutamate synthase
HKK73_RS10245	COG0070	glutamate synthase
HKK73_RS10250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HKK73_RS10255	COG0159	tryptophan synthase activity
HKK73_RS10260	COG0133	tryptophan synthase activity
HKK73_RS10265	COG0134	indole-3-glycerol-phosphate synthase activity
HKK73_RS10295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HKK73_RS10300	COG1132	(ABC) transporter
HKK73_RS10305	COG1132	(ABC) transporter
HKK73_RS10310	COG0107	imidazoleglycerol-phosphate synthase activity
HKK73_RS10320	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HKK73_RS10325	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HKK73_RS10330	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HKK73_RS10340	COG4122	O-methyltransferase activity
HKK73_RS10345	COG1222	aaa ATPase
HKK73_RS10355	COG0517	IMP dehydrogenase activity
HKK73_RS10355	COG1994	Peptidase M50
HKK73_RS10360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKK73_RS10375	COG0215	cysteine-tRNA ligase activity
HKK73_RS10380	COG0598	Magnesium transport protein CorA
HKK73_RS10385	COG1968	undecaprenyl-diphosphatase activity
HKK73_RS10390	COG0667	Aldo Keto reductase
HKK73_RS10410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKK73_RS10415	COG2132	Multicopper oxidase
HKK73_RS10430	COG2197	response regulator
HKK73_RS10440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKK73_RS10475	COG0300	oxidoreductase activity
HKK73_RS10500	COG1131	(ABC) transporter
HKK73_RS10515	COG4585	Histidine kinase
HKK73_RS10520	COG2197	response regulator
HKK73_RS10525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HKK73_RS10570	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HKK73_RS10595	COG1175	transmembrane transport
HKK73_RS10600	COG0395	ABC-type sugar transport system, permease component
HKK73_RS10655	COG3546	catalase activity
HKK73_RS10665	COG0300	oxidoreductase activity
HKK73_RS10710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HKK73_RS10715	COG1012	belongs to the aldehyde dehydrogenase family
HKK73_RS10720	COG2192	nodulation
HKK73_RS10725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HKK73_RS10730	COG0859	PFAM glycosyl transferase family 9
HKK73_RS10740	COG0438	transferase activity, transferring glycosyl groups
HKK73_RS10745	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HKK73_RS10745	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HKK73_RS10750	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS10760	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS10770	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HKK73_RS10775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKK73_RS10780	COG0531	amino acid
HKK73_RS10785	COG1609	Transcriptional regulator
HKK73_RS10795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK73_RS10820	COG0745	RESPONSE REGULATOR receiver
HKK73_RS10825	COG2205	protein histidine kinase activity
HKK73_RS10830	COG1690	Belongs to the RtcB family
HKK73_RS10850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HKK73_RS10860	COG0673	inositol 2-dehydrogenase activity
HKK73_RS10875	COG0587	DNA-directed DNA polymerase activity
HKK73_RS10895	COG3973	AAA domain
HKK73_RS10915	COG1120	ATPase activity
HKK73_RS10985	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKK73_RS10995	COG1937	Protein conserved in bacteria
HKK73_RS11025	COG1119	ATPase activity
HKK73_RS11040	COG0297	glycogen (starch) synthase activity
HKK73_RS11050	COG3830	Belongs to the UPF0237 family
HKK73_RS11050	COG0560	Phosphoserine phosphatase
HKK73_RS11055	COG2062	phosphohistidine phosphatase, SixA
HKK73_RS11065	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS11085	COG0488	(ABC) transporter
HKK73_RS11110	COG0456	acetyltransferase
HKK73_RS11115	COG0646	methionine synthase
HKK73_RS11115	COG1410	methionine synthase
HKK73_RS11130	COG3655	Transcriptional regulator
HKK73_RS11165	COG0187	DNA topoisomerase II activity
HKK73_RS11180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HKK73_RS11185	COG0589	response to stress
HKK73_RS11210	COG2815	serine threonine protein kinase
HKK73_RS11210	COG0515	serine threonine protein kinase
HKK73_RS11215	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HKK73_RS11235	COG1940	carbohydrate kinase activity
HKK73_RS11260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HKK73_RS11270	COG1845	cytochrome c oxidase, subunit III
HKK73_RS11275	COG2010	Cytochrome c
HKK73_RS11280	COG0723	plastoquinol--plastocyanin reductase activity
HKK73_RS11285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HKK73_RS11300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKK73_RS11305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HKK73_RS11310	COG1104	cysteine desulfurase activity
HKK73_RS11315	COG0425	Belongs to the sulfur carrier protein TusA family
HKK73_RS11315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HKK73_RS11335	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HKK73_RS11345	COG2409	Drug exporters of the RND superfamily
HKK73_RS11355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HKK73_RS11365	COG0667	Aldo Keto reductase
HKK73_RS11385	COG0167	dihydroorotate dehydrogenase activity
HKK73_RS11400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HKK73_RS11410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKK73_RS11415	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKK73_RS11420	COG1090	epimerase
HKK73_RS11430	COG0673	inositol 2-dehydrogenase activity
HKK73_RS11440	COG2409	Drug exporters of the RND superfamily
HKK73_RS11445	COG1846	Transcriptional regulator
HKK73_RS11450	COG0321	lipoyl(octanoyl) transferase activity
HKK73_RS11460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HKK73_RS11475	COG0174	glutamine synthetase
HKK73_RS11485	COG2072	flavoprotein involved in K transport
HKK73_RS11490	COG0490	domain, Protein
HKK73_RS11490	COG0471	metal ion transport
HKK73_RS11500	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HKK73_RS11505	COG0174	glutamine synthetase
HKK73_RS11510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HKK73_RS11510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK73_RS11515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HKK73_RS11525	COG0860	N-Acetylmuramoyl-L-alanine amidase
HKK73_RS11550	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HKK73_RS11555	COG0351	phosphomethylpyrimidine kinase
HKK73_RS11575	COG3973	AAA domain
HKK73_RS11575	COG3973	AAA domain
HKK73_RS11580	COG0514	ATP-dependent DNA helicase (RecQ)
HKK73_RS11590	COG3022	response to hydroperoxide
HKK73_RS11610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HKK73_RS11620	COG0659	secondary active sulfate transmembrane transporter activity
HKK73_RS11635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKK73_RS11635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HKK73_RS11645	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HKK73_RS11650	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HKK73_RS11655	COG0714	Associated with various cellular activities
HKK73_RS11665	COG3831	ATPase activity
HKK73_RS11695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKK73_RS11715	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HKK73_RS11735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKK73_RS11740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKK73_RS11745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKK73_RS11795	COG0358	DNA primase activity
HKK73_RS11820	COG0366	Alpha amylase catalytic
HKK73_RS11825	COG3833	ABC-type maltose transport systems, permease component
HKK73_RS11830	COG1175	transmembrane transport
HKK73_RS11840	COG1609	Transcriptional regulator
HKK73_RS11845	COG0366	Alpha amylase catalytic
HKK73_RS11860	COG0423	glycine-tRNA ligase activity
HKK73_RS11865	COG3443	Belongs to the bacterial solute-binding protein 9 family
HKK73_RS11865	COG0803	Belongs to the bacterial solute-binding protein 9 family
HKK73_RS11870	COG1121	(ABC) transporter
HKK73_RS11875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKK73_RS11900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKK73_RS11905	COG1381	Involved in DNA repair and RecF pathway recombination
HKK73_RS11925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HKK73_RS11945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HKK73_RS11955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HKK73_RS11965	COG0537	adenosine 5'-monophosphoramidase activity
HKK73_RS11975	COG0484	heat shock protein binding
HKK73_RS11980	COG1420	regulation of RNA biosynthetic process
HKK73_RS11985	COG0477	Major facilitator Superfamily
HKK73_RS12005	COG0481	GTPase activity
HKK73_RS12020	COG0268	Binds directly to 16S ribosomal RNA
HKK73_RS12035	COG2183	response to ionizing radiation
HKK73_RS12040	COG1307	EDD domain protein, DegV family
HKK73_RS12055	COG0433	COG0433 Predicted ATPase
HKK73_RS12075	COG2814	Major facilitator Superfamily
HKK73_RS12095	COG0477	Major facilitator Superfamily
HKK73_RS12115	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HKK73_RS12125	COG2357	RelA SpoT domain protein
HKK73_RS12130	COG1793	dna ligase
HKK73_RS12130	COG3285	dna ligase
HKK73_RS12140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKK73_RS12155	COG0662	Cupin 2, conserved barrel domain protein
HKK73_RS12170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HKK73_RS12180	COG0259	pyridoxamine-phosphate oxidase activity
HKK73_RS12190	COG0579	oxidoreductase
HKK73_RS12230	COG4989	oxidoreductase activity
HKK73_RS12260	COG0588	phosphoglycerate mutase activity
HKK73_RS12265	COG0799	negative regulation of ribosome biogenesis
HKK73_RS12275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HKK73_RS12285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HKK73_RS12290	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HKK73_RS12295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HKK73_RS12300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HKK73_RS12305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HKK73_RS12315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HKK73_RS12320	COG1435	thymidine kinase activity
HKK73_RS12330	COG1530	ribonuclease E activity
HKK73_RS12335	COG1271	oxidase subunit
HKK73_RS12340	COG1294	oxidase, subunit
HKK73_RS12345	COG4988	ABC transporter
HKK73_RS12350	COG1132	(ABC) transporter
HKK73_RS12365	COG0531	amino acid
HKK73_RS12375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HKK73_RS12380	COG0571	ribonuclease III activity
HKK73_RS12385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HKK73_RS12400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HKK73_RS12410	COG0742	ribosomal rna small subunit methyltransferase
HKK73_RS12415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKK73_RS12420	COG1461	Dihydroxyacetone kinase
HKK73_RS12425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HKK73_RS12445	COG1181	Belongs to the D-alanine--D-alanine ligase family
HKK73_RS12485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HKK73_RS12495	COG2197	response regulator
HKK73_RS12500	COG4585	Histidine kinase
HKK73_RS12505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKK73_RS12510	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKK73_RS12515	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS12535	COG0495	leucyl-tRNA aminoacylation
HKK73_RS12540	COG2354	Protein conserved in bacteria
HKK73_RS12545	COG1253	flavin adenine dinucleotide binding
HKK73_RS12550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS12555	COG0066	3-isopropylmalate dehydratase activity
HKK73_RS12560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HKK73_RS12565	COG1414	Transcriptional regulator
HKK73_RS12605	COG2855	membrane
HKK73_RS12615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKK73_RS12625	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKK73_RS12640	COG0667	Aldo Keto reductase
HKK73_RS12755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKK73_RS12770	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HKK73_RS12775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HKK73_RS12780	COG1472	Belongs to the glycosyl hydrolase 3 family
HKK73_RS12785	COG0395	ABC-type sugar transport system, permease component
HKK73_RS12790	COG1175	transmembrane transport
HKK73_RS12795	COG2182	Extracellular solute-binding protein
HKK73_RS12800	COG0095	Lipoate-protein ligase
HKK73_RS12805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HKK73_RS12815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HKK73_RS12820	COG0473	3-isopropylmalate dehydrogenase activity
HKK73_RS12825	COG1940	carbohydrate kinase activity
HKK73_RS12835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HKK73_RS12840	COG0440	acetolactate synthase activity
HKK73_RS12850	COG0366	Alpha amylase catalytic
HKK73_RS12875	COG0463	Glycosyl transferase, family 2
HKK73_RS12885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HKK73_RS12890	COG2124	cytochrome p450
HKK73_RS12895	COG2154	pterin-4-alpha-carbinolamine dehydratase
HKK73_RS12900	COG0129	dihydroxy-acid dehydratase activity
HKK73_RS12910	COG0129	dihydroxy-acid dehydratase activity
HKK73_RS12920	COG3104	oligopeptide transport
HKK73_RS12940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HKK73_RS12945	COG3960	tartronate-semialdehyde synthase activity
HKK73_RS12950	COG2084	Dehydrogenase
HKK73_RS12955	COG3622	Belongs to the hyi family
HKK73_RS12960	COG3257	ureidoglycine aminohydrolase activity
HKK73_RS12980	COG1414	Transcriptional regulator
HKK73_RS13010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKK73_RS13015	COG0154	amidase activity
HKK73_RS13020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKK73_RS13040	COG1984	allophanate hydrolase subunit 2
HKK73_RS13045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HKK73_RS13075	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK73_RS13080	COG4211	Belongs to the binding-protein-dependent transport system permease family
HKK73_RS13085	COG1129	ABC transporter
HKK73_RS13090	COG0673	inositol 2-dehydrogenase activity
HKK73_RS13115	COG1879	ABC-type sugar transport system periplasmic component
HKK73_RS13120	COG1172	Belongs to the binding-protein-dependent transport system permease family
HKK73_RS13125	COG1129	ABC transporter
HKK73_RS13130	COG1940	carbohydrate kinase activity
HKK73_RS13140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKK73_RS13150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HKK73_RS13165	COG2197	response regulator
HKK73_RS13180	COG1454	alcohol dehydrogenase
HKK73_RS13180	COG1012	belongs to the aldehyde dehydrogenase family
HKK73_RS13185	COG1505	serine-type exopeptidase activity
HKK73_RS13210	COG0482	sulfurtransferase activity
HKK73_RS13265	COG0366	Alpha amylase catalytic
HKK73_RS13275	COG3281	Trehalose synthase
HKK73_RS13310	COG3833	ABC-type maltose transport systems, permease component
HKK73_RS13315	COG1175	transmembrane transport
HKK73_RS13325	COG1609	Transcriptional regulator
HKK73_RS13330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HKK73_RS13360	COG2267	carboxylic ester hydrolase activity
HKK73_RS13375	COG0545	Peptidyl-prolyl cis-trans isomerase
HKK73_RS13380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HKK73_RS13385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKK73_RS13395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKK73_RS13400	COG1780	Probably involved in ribonucleotide reductase function
HKK73_RS13415	COG1501	Belongs to the glycosyl hydrolase 31 family
HKK73_RS13425	COG1175	transmembrane transport
HKK73_RS13430	COG1653	transport
HKK73_RS13445	COG4762	Protein conserved in bacteria
HKK73_RS13460	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HKK73_RS13470	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HKK73_RS13475	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HKK73_RS13480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HKK73_RS13485	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HKK73_RS13490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HKK73_RS13505	COG0356	it plays a direct role in the translocation of protons across the membrane
HKK73_RS13520	COG0009	L-threonylcarbamoyladenylate synthase
HKK73_RS13530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HKK73_RS13535	COG0254	rRNA binding
HKK73_RS13545	COG0083	homoserine kinase activity
HKK73_RS13550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HKK73_RS13555	COG0460	homoserine dehydrogenase
HKK73_RS13560	COG0019	diaminopimelate decarboxylase activity
HKK73_RS13565	COG0018	arginyl-trna synthetase
HKK73_RS13595	COG1253	flavin adenine dinucleotide binding
HKK73_RS13600	COG0745	RESPONSE REGULATOR receiver
HKK73_RS13605	COG2205	protein histidine kinase activity
HKK73_RS13610	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKK73_RS13610	COG0567	Dehydrogenase, E1 component
HKK73_RS13645	COG5662	AntiSigma factor
HKK73_RS13660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HKK73_RS13670	COG0483	inositol monophosphate 1-phosphatase activity
HKK73_RS13710	COG0653	protein targeting
HKK73_RS13715	COG3214	Protein conserved in bacteria
HKK73_RS13720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HKK73_RS13730	COG5401	PFAM Sporulation and spore germination
HKK73_RS13735	COG5002	protein histidine kinase activity
HKK73_RS13735	COG5000	phosphorelay sensor kinase activity
HKK73_RS13740	COG0745	RESPONSE REGULATOR receiver
HKK73_RS13760	COG0714	Associated with various cellular activities
HKK73_RS13790	COG2197	response regulator
HKK73_RS13805	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HKK73_RS13815	COG4176	ABC-type proline glycine betaine transport system permease component
HKK73_RS13835	COG1216	Glycosyl transferase, family 2
HKK73_RS13850	COG1216	Glycosyl transferase, family 2
HKK73_RS13860	COG2835	tetraacyldisaccharide 4'-kinase activity
HKK73_RS13865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKK73_RS13900	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HKK73_RS13910	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HKK73_RS13915	COG1088	dTDP-glucose 4,6-dehydratase activity
HKK73_RS13930	COG1215	transferase activity, transferring glycosyl groups
HKK73_RS13950	COG1216	Glycosyl transferase, family 2
HKK73_RS13995	COG1316	TRANSCRIPTIONal
HKK73_RS14000	COG1316	TRANSCRIPTIONal
HKK73_RS14005	COG2755	lipolytic protein G-D-S-L family
HKK73_RS14005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HKK73_RS14020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HKK73_RS14035	COG2205	protein histidine kinase activity
HKK73_RS14040	COG0745	RESPONSE REGULATOR receiver
HKK73_RS14045	COG4585	Histidine kinase
HKK73_RS14050	COG2197	response regulator
HKK73_RS14055	COG4591	ABC-type transport system involved in lipoprotein release permease component
HKK73_RS14055	COG1136	(ABC) transporter
HKK73_RS14105	COG2723	6-phospho-beta-galactosidase activity
HKK73_RS14120	COG1012	belongs to the aldehyde dehydrogenase family
HKK73_RS14130	COG0656	L-ascorbic acid biosynthetic process
HKK73_RS14135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKK73_RS14165	COG0395	ABC-type sugar transport system, permease component
HKK73_RS14170	COG4209	transmembrane transport
HKK73_RS14180	COG0366	Alpha amylase catalytic
HKK73_RS14190	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HKK73_RS14195	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HKK73_RS14215	COG1929	Belongs to the glycerate kinase type-1 family
HKK73_RS14225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKK73_RS14235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKK73_RS14245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HKK73_RS14255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKK73_RS14260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKK73_RS14275	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS14280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HKK73_RS14305	COG0640	Transcriptional regulator
HKK73_RS14330	COG2813	Specifically methylates the guanine in position
HKK73_RS14380	COG4585	Histidine kinase
HKK73_RS14385	COG2197	response regulator
HKK73_RS14390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKK73_RS14430	COG0740	serine-type endopeptidase activity
HKK73_RS14435	COG0740	serine-type endopeptidase activity
HKK73_RS14445	COG1396	sequence-specific DNA binding
HKK73_RS14450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HKK73_RS14455	COG2514	catechol 2,3-dioxygenase activity
HKK73_RS14470	COG1252	NADH dehydrogenase
HKK73_RS14495	COG0148	phosphopyruvate hydratase activity
HKK73_RS14520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKK73_RS14535	COG0489	protein tyrosine kinase activity
HKK73_RS14565	COG0438	transferase activity, transferring glycosyl groups
HKK73_RS14590	COG0193	aminoacyl-tRNA hydrolase activity
HKK73_RS14595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HKK73_RS14610	COG2968	Membrane
HKK73_RS14625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HKK73_RS14635	COG1309	transcriptional regulator
HKK73_RS14645	COG4152	abc transporter atp-binding protein
HKK73_RS14650	COG1668	transmembrane transport
HKK73_RS14655	COG1846	Transcriptional regulator
HKK73_RS14660	COG2807	transmembrane transport
HKK73_RS14695	COG0488	(ABC) transporter
HKK73_RS14710	COG1175	transmembrane transport
HKK73_RS14735	COG3458	cephalosporin-C deacetylase activity
HKK73_RS14740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HKK73_RS14745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HKK73_RS14750	COG3583	domain protein
HKK73_RS14770	COG0084	hydrolase, TatD family'
HKK73_RS14775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKK73_RS14795	COG0436	Aminotransferase
HKK73_RS14805	COG1335	isochorismatase
HKK73_RS14840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HKK73_RS14865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKK73_RS14890	COG1970	mechanosensitive ion channel activity
HKK73_RS14910	COG3707	response regulator
HKK73_RS14930	COG1126	abc transporter atp-binding protein
HKK73_RS14935	COG0765	amino acid transport
HKK73_RS14940	COG0765	amino acid transport
HKK73_RS14945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKK73_RS14960	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HKK73_RS14985	COG1834	amidinotransferase
HKK73_RS14990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKK73_RS14995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK73_RS15015	COG0791	NLP P60 protein
HKK73_RS15015	COG1388	LysM domain
HKK73_RS15015	COG3103	Sh3 type 3 domain protein
HKK73_RS15025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HKK73_RS15030	COG2814	Major facilitator Superfamily
HKK73_RS15050	COG1316	TRANSCRIPTIONal
HKK73_RS15065	COG1316	TRANSCRIPTIONal
HKK73_RS15080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HKK73_RS15100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HKK73_RS15110	COG1482	cell wall glycoprotein biosynthetic process
HKK73_RS15115	COG2252	PERMEase
HKK73_RS15125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HKK73_RS15145	COG1278	Cold shock
HKK73_RS15170	COG1061	Type III restriction enzyme res subunit
HKK73_RS15180	COG1842	Phage shock protein A
HKK73_RS15200	COG0745	RESPONSE REGULATOR receiver
HKK73_RS15205	COG2205	protein histidine kinase activity
HKK73_RS15220	COG0459	protein refolding
HKK73_RS15250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HKK73_RS15275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKK73_RS15275	COG0515	serine threonine protein kinase
HKK73_RS15280	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HKK73_RS15290	COG3842	ATPase activity
HKK73_RS15305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKK73_RS15310	COG0215	cysteine-tRNA ligase activity
HKK73_RS15335	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HKK73_RS15340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HKK73_RS15345	COG1329	Transcriptional regulator
HKK73_RS15360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKK73_RS15365	COG0581	inorganic phosphate transmembrane transporter activity
HKK73_RS15385	COG5002	protein histidine kinase activity
HKK73_RS15390	COG0704	Plays a role in the regulation of phosphate uptake
HKK73_RS15395	COG0588	phosphoglycerate mutase activity
HKK73_RS15405	COG0297	glycogen (starch) synthase activity
HKK73_RS15425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HKK73_RS15435	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HKK73_RS15440	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HKK73_RS15475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKK73_RS15480	COG0302	gtp cyclohydrolase
HKK73_RS15485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKK73_RS15495	COG0037	tRNA processing
HKK73_RS15520	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HKK73_RS15530	COG2873	o-acetylhomoserine
HKK73_RS15535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKK73_RS15540	COG0604	alcohol dehydrogenase
HKK73_RS15590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HKK73_RS15595	COG1920	GTP binding
HKK73_RS15615	COG0667	Aldo Keto reductase
HKK73_RS15625	COG4716	Myosin-crossreactive antigen
HKK73_RS15630	COG0247	lactate metabolic process
HKK73_RS15630	COG0277	FAD linked oxidase domain protein
HKK73_RS15665	COG1404	Belongs to the peptidase S8 family
HKK73_RS15710	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HKK73_RS15760	COG0598	Magnesium transport protein CorA
HKK73_RS15770	COG1490	D-aminoacyl-tRNA deacylase activity
HKK73_RS15795	COG4129	membrane
HKK73_RS15800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HKK73_RS15805	COG3485	protocatechuate 3,4-dioxygenase
HKK73_RS15835	COG2267	carboxylic ester hydrolase activity
HKK73_RS15860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HKK73_RS15865	COG1408	metallophosphoesterase
HKK73_RS15885	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HKK73_RS15890	COG2079	MmgE PrpD family protein
HKK73_RS15895	COG1802	Transcriptional regulator
HKK73_RS15905	COG1595	DNA-templated transcription, initiation
HKK73_RS15935	COG1595	DNA-templated transcription, initiation
HKK73_RS15940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKK73_RS15955	COG0596	Alpha beta hydrolase
HKK73_RS15965	COG0730	response to heat
HKK73_RS15970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKK73_RS15980	COG1131	(ABC) transporter
HKK73_RS15990	COG3845	ABC transporter
HKK73_RS16020	COG2116	formate transmembrane transporter activity
HKK73_RS16050	COG0640	Transcriptional regulator
HKK73_RS16065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HKK73_RS16080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKK73_RS16085	COG1464	Belongs to the NlpA lipoprotein family
HKK73_RS16100	COG1309	transcriptional regulator
HKK73_RS16105	COG1131	(ABC) transporter
HKK73_RS16110	COG3559	Exporter of polyketide antibiotics
HKK73_RS16135	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HKK73_RS16140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HKK73_RS16145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HKK73_RS16175	COG2233	PERMEase
HKK73_RS16215	COG1132	(ABC) transporter
HKK73_RS16220	COG1309	transcriptional regulator
HKK73_RS16250	COG1960	acyl-CoA dehydrogenase activity
HKK73_RS16255	COG0183	Belongs to the thiolase family
HKK73_RS16270	COG0671	phosphoesterase, PA-phosphatase related
HKK73_RS16360	COG0037	tRNA processing
HKK73_RS16360	COG0590	tRNA wobble adenosine to inosine editing
HKK73_RS16365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HKK73_RS16370	COG0745	RESPONSE REGULATOR receiver
HKK73_RS16395	COG0789	Transcriptional regulator
HKK73_RS16400	COG0484	heat shock protein binding
HKK73_RS16410	COG0443	Heat shock 70 kDa protein
HKK73_RS16420	COG1278	Cold shock
HKK73_RS16445	COG1027	Aspartate ammonia-lyase
HKK73_RS16455	COG1472	Belongs to the glycosyl hydrolase 3 family
HKK73_RS16460	COG0395	ABC-type sugar transport system, permease component
HKK73_RS16465	COG1175	transmembrane transport
HKK73_RS16475	COG1609	Transcriptional regulator
HKK73_RS16495	COG3135	benzoate transporter
HKK73_RS16505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS16515	COG2211	Major facilitator Superfamily
HKK73_RS16525	COG1940	carbohydrate kinase activity
HKK73_RS16550	COG2261	transglycosylase associated protein
HKK73_RS16570	COG0166	Belongs to the GPI family
HKK73_RS16575	COG1366	Belongs to the anti-sigma-factor antagonist family
HKK73_RS16580	COG1366	Belongs to the anti-sigma-factor antagonist family
HKK73_RS16585	COG2172	sigma factor antagonist activity
HKK73_RS16595	COG5002	protein histidine kinase activity
HKK73_RS16595	COG2198	Histidine kinase
HKK73_RS16595	COG0784	Response regulator, receiver
HKK73_RS16600	COG0745	RESPONSE REGULATOR receiver
HKK73_RS16615	COG4585	Histidine kinase
HKK73_RS16620	COG2197	response regulator
HKK73_RS16630	COG3842	ATPase activity
HKK73_RS16635	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HKK73_RS16640	COG4143	(ABC) transporter
HKK73_RS16645	COG1136	(ABC) transporter
HKK73_RS16705	COG1028	Short-chain dehydrogenase reductase Sdr
HKK73_RS16725	COG0315	cyclic pyranopterin monophosphate synthase activity
HKK73_RS16730	COG0746	molybdenum cofactor guanylyltransferase activity
HKK73_RS16745	COG0521	Mo-molybdopterin cofactor biosynthetic process
HKK73_RS16745	COG0315	cyclic pyranopterin monophosphate synthase activity
HKK73_RS16780	COG0454	-acetyltransferase
HKK73_RS16800	COG3239	Fatty acid desaturase
HKK73_RS16815	COG3585	molybdate ion transport
HKK73_RS16835	COG3265	gluconokinase activity
HKK73_RS16840	COG2610	gluconate transmembrane transporter activity
HKK73_RS16860	COG0545	Peptidyl-prolyl cis-trans isomerase
HKK73_RS16870	COG0328	RNA-DNA hybrid ribonuclease activity
HKK73_RS16895	COG0588	phosphoglycerate mutase activity
HKK73_RS16905	COG2258	MOSC domain
HKK73_RS16910	COG1070	Carbohydrate kinase
HKK73_RS16945	COG1136	(ABC) transporter
HKK73_RS16955	COG0318	PFAM AMP-dependent synthetase and ligase
HKK73_RS16980	COG2234	aminopeptidase activity
HKK73_RS16985	COG1199	ATP-dependent helicase activity
HKK73_RS16985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKK73_RS17020	COG4702	Belongs to the UPF0303 family
HKK73_RS17060	COG3483	tryptophan 2,3-dioxygenase activity
HKK73_RS17065	COG0406	alpha-ribazole phosphatase activity
HKK73_RS17070	COG1234	tRNA 3'-trailer cleavage
HKK73_RS17085	COG0584	glycerophosphoryl diester phosphodiesterase
HKK73_RS17090	COG1653	transport
HKK73_RS17100	COG1175	transmembrane transport
HKK73_RS17120	COG4585	Histidine kinase
HKK73_RS17130	COG3663	DNA glycosylase
HKK73_RS17135	COG0235	Class ii aldolase
HKK73_RS17140	COG3395	kinase activity
HKK73_RS17145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HKK73_RS17150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HKK73_RS17155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HKK73_RS17160	COG1063	alcohol dehydrogenase
HKK73_RS17165	COG2186	Transcriptional regulator
HKK73_RS17170	COG2197	response regulator
HKK73_RS17175	COG0210	DNA helicase
HKK73_RS17180	COG1201	RNA secondary structure unwinding
HKK73_RS17190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HKK73_RS17220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HKK73_RS17345	COG0584	glycerophosphoryl diester phosphodiesterase
HKK73_RS17375	COG0252	asparaginase activity
HKK73_RS17390	COG2301	Belongs to the HpcH HpaI aldolase family
HKK73_RS17395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKK73_RS17400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HKK73_RS17405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKK73_RS17460	COG3012	SEC-C Motif Domain Protein
HKK73_RS17470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS17510	COG1472	Belongs to the glycosyl hydrolase 3 family
HKK73_RS17595	COG0683	leucine binding
HKK73_RS17600	COG1278	Cold shock
HKK73_RS17625	COG1126	abc transporter atp-binding protein
HKK73_RS17645	COG0733	neurotransmitter:sodium symporter activity
HKK73_RS17650	COG0277	FAD linked oxidase domain protein
HKK73_RS17705	COG0419	ATPase involved in DNA repair
HKK73_RS17710	COG0420	3'-5' exonuclease activity
HKK73_RS17715	COG1366	Belongs to the anti-sigma-factor antagonist family
HKK73_RS17720	COG0442	prolyl-tRNA aminoacylation
HKK73_RS17730	COG0488	(ABC) transporter
HKK73_RS17735	COG1876	peptidase activity
HKK73_RS17780	COG0010	Belongs to the arginase family
HKK73_RS17785	COG1228	amidohydrolase
HKK73_RS17790	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HKK73_RS17800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKK73_RS17825	COG1121	(ABC) transporter
HKK73_RS17830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKK73_RS17840	COG1597	lipid kinase activity
HKK73_RS17850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKK73_RS17875	COG0596	Alpha beta hydrolase
HKK73_RS17885	COG1487	ribonuclease activity
HKK73_RS17890	COG4691	Plasmid stability protein
HKK73_RS17895	COG1643	Atp-dependent helicase
HKK73_RS17905	COG1136	(ABC) transporter
HKK73_RS17935	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HKK73_RS17985	COG0519	Catalyzes the synthesis of GMP from XMP
HKK73_RS17990	COG1760	l-serine dehydratase
HKK73_RS17995	COG0110	maltose O-acetyltransferase activity
HKK73_RS18010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HKK73_RS18045	COG0656	L-ascorbic acid biosynthetic process
HKK73_RS18050	COG0789	Transcriptional regulator
HKK73_RS18065	COG2197	response regulator
HKK73_RS18070	COG4585	Histidine kinase
HKK73_RS18080	COG0204	Acyl-transferase
HKK73_RS18080	COG0318	PFAM AMP-dependent synthetase and ligase
HKK73_RS18085	COG1113	amino acid transport
HKK73_RS18100	COG0475	glutathione-regulated potassium exporter activity
HKK73_RS18125	COG0738	Major facilitator superfamily
HKK73_RS18130	COG0110	maltose O-acetyltransferase activity
HKK73_RS18135	COG3226	Transcriptional regulator
HKK73_RS18140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKK73_RS18145	COG1966	Carbon starvation protein
HKK73_RS18180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HKK73_RS18185	COG3275	phosphorelay sensor kinase activity
HKK73_RS18190	COG3279	Response regulator of the LytR AlgR family
HKK73_RS18200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKK73_RS18205	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HKK73_RS18210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HKK73_RS18230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HKK73_RS18245	COG2409	Drug exporters of the RND superfamily
HKK73_RS18260	COG0738	Major facilitator superfamily
HKK73_RS18305	COG0277	FAD linked oxidase domain protein
HKK73_RS18310	COG1737	Transcriptional regulator
HKK73_RS18315	COG2971	BadF BadG BcrA BcrD
HKK73_RS18320	COG2197	response regulator
HKK73_RS18325	COG3850	Histidine kinase
HKK73_RS18355	COG0386	Belongs to the glutathione peroxidase family
HKK73_RS18375	COG2258	MOSC domain
HKK73_RS18420	COG1793	dna ligase
HKK73_RS18460	COG3903	Transcriptional regulator
HKK73_RS18460	COG3629	intracellular signal transduction
HKK73_RS18465	COG0596	Alpha beta hydrolase
HKK73_RS18510	COG1914	H( )-stimulated, divalent metal cation uptake system
HKK73_RS18525	COG0655	NAD(P)H dehydrogenase (quinone) activity
HKK73_RS18530	COG0640	Transcriptional regulator
HKK73_RS18540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HKK73_RS18545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HKK73_RS18560	COG2235	arginine
HKK73_RS18575	COG1802	Transcriptional regulator
HKK73_RS18585	COG3459	Glycosyltransferase 36 associated
HKK73_RS18590	COG1309	transcriptional regulator
HKK73_RS18595	COG1653	transport
HKK73_RS18600	COG1175	transmembrane transport
HKK73_RS18605	COG0395	ABC-type sugar transport system, permease component
HKK73_RS18610	COG2723	6-phospho-beta-galactosidase activity
HKK73_RS18615	COG1609	Transcriptional regulator
HKK73_RS18620	COG3459	Glycosyltransferase 36 associated
HKK73_RS18630	COG0832	Belongs to the urease beta subunit family
HKK73_RS18635	COG0804	urea catabolic process
HKK73_RS18645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HKK73_RS18650	COG0829	nickel cation binding
HKK73_RS18655	COG0310	cobalt ion transport
HKK73_RS18685	COG1802	Transcriptional regulator
HKK73_RS18695	COG0305	Participates in initiation and elongation during chromosome replication
HKK73_RS18700	COG0534	Mate efflux family protein
HKK73_RS18705	COG0359	binds to the 23S rRNA
HKK73_RS18710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HKK73_RS18720	COG0360	Binds together with S18 to 16S ribosomal RNA
HKK73_RS18725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKK73_RS18735	COG1260	myo-inositol-1-phosphate synthase
HKK73_RS18745	COG0477	Major facilitator Superfamily
HKK73_RS18750	COG0617	tRNA 3'-terminal CCA addition
HKK73_RS18780	COG3118	belongs to the thioredoxin family
HKK73_RS18785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKK73_RS18790	COG1181	Belongs to the D-alanine--D-alanine ligase family
HKK73_RS18800	COG1192	Involved in chromosome partitioning
HKK73_RS18805	COG0357	Ribosomal RNA small subunit methyltransferase G
HKK73_RS18810	COG1847	R3H domain protein
HKK73_RS18815	COG0706	membrane insertase activity
HKK73_RS18820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HKK73_RS18825	COG0594	ribonuclease P activity
HKK73_RS18830	COG0230	Belongs to the bacterial ribosomal protein bL34 family