locus-tag	class	description
GWR21_RS00025	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GWR21_RS00030	COG4974	Belongs to the 'phage' integrase family
GWR21_RS00055	COG4974	Belongs to the 'phage' integrase family
GWR21_RS00060	COG4974	Belongs to the 'phage' integrase family
GWR21_RS00065	COG4974	Belongs to the 'phage' integrase family
GWR21_RS00090	COG4974	Belongs to the 'phage' integrase family
GWR21_RS00095	COG4974	Belongs to the 'phage' integrase family
GWR21_RS00120	COG4974	Belongs to the 'phage' integrase family
GWR21_RS00125	COG4974	Belongs to the 'phage' integrase family
GWR21_RS00195	COG0583	DNA-binding transcription factor activity
GWR21_RS00210	COG3693	PFAM glycoside hydrolase, family 10
GWR21_RS00225	COG1629	transport
GWR21_RS00230	COG0702	epimerase
GWR21_RS00250	COG4251	negative regulation of phosphorylation
GWR21_RS00275	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GWR21_RS00280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWR21_RS00285	COG1174	glycine betaine transport
GWR21_RS00290	COG0517	IMP dehydrogenase activity
GWR21_RS00290	COG1125	glycine betaine transport
GWR21_RS00330	COG3850	Histidine kinase
GWR21_RS00330	COG2205	protein histidine kinase activity
GWR21_RS00330	COG3437	response regulator, receiver
GWR21_RS00330	COG4999	Histidine kinase
GWR21_RS00355	COG2217	Heavy metal translocating P-type atpase
GWR21_RS00385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWR21_RS00400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWR21_RS00405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWR21_RS00410	COG4251	negative regulation of phosphorylation
GWR21_RS00425	COG3347	Dehydrogenase
GWR21_RS00425	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS00430	COG4952	isomerase
GWR21_RS00440	COG0247	lactate metabolic process
GWR21_RS00445	COG1139	Iron-sulfur cluster binding protein
GWR21_RS00450	COG1556	Lactate utilization protein
GWR21_RS00455	COG3254	rhamnose metabolic process
GWR21_RS00520	COG0367	asparagine synthase
GWR21_RS00525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWR21_RS00525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWR21_RS00545	COG1309	transcriptional regulator
GWR21_RS00550	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS00590	COG0420	3'-5' exonuclease activity
GWR21_RS00615	COG0745	RESPONSE REGULATOR receiver
GWR21_RS00625	COG1611	Belongs to the LOG family
GWR21_RS00630	COG1063	alcohol dehydrogenase
GWR21_RS00670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWR21_RS00670	COG0574	Belongs to the PEP-utilizing enzyme family
GWR21_RS00675	COG0745	RESPONSE REGULATOR receiver
GWR21_RS00680	COG0071	Belongs to the small heat shock protein (HSP20) family
GWR21_RS00700	COG2823	Periplasmic or secreted lipoprotein
GWR21_RS00705	COG1994	Peptidase M50
GWR21_RS00705	COG0517	IMP dehydrogenase activity
GWR21_RS00725	COG0438	transferase activity, transferring glycosyl groups
GWR21_RS00765	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GWR21_RS00765	COG2755	lipolytic protein G-D-S-L family
GWR21_RS00770	COG0596	Alpha beta hydrolase
GWR21_RS00775	COG3604	Transcriptional regulator
GWR21_RS00800	COG4771	TonB-dependent receptor
GWR21_RS00825	COG1609	Transcriptional regulator
GWR21_RS00830	COG1312	Catalyzes the dehydration of D-mannonate
GWR21_RS00835	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS00935	COG2076	Multidrug Resistance protein
GWR21_RS00945	COG1595	DNA-templated transcription, initiation
GWR21_RS00955	COG1629	transport
GWR21_RS00960	COG0702	epimerase
GWR21_RS00975	COG3537	Alpha-1,2-mannosidase
GWR21_RS00980	COG0702	epimerase
GWR21_RS00995	COG4771	TonB-dependent receptor
GWR21_RS01000	COG0702	epimerase
GWR21_RS01005	COG1629	transport
GWR21_RS01035	COG0456	acetyltransferase
GWR21_RS01045	COG4221	oxidoreductase activity
GWR21_RS01045	COG0604	alcohol dehydrogenase
GWR21_RS01045	COG3321	synthase
GWR21_RS01045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWR21_RS01065	COG0489	protein tyrosine kinase activity
GWR21_RS01070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWR21_RS01085	COG2089	acid synthase
GWR21_RS01090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWR21_RS01190	COG3604	Transcriptional regulator
GWR21_RS01195	COG0745	RESPONSE REGULATOR receiver
GWR21_RS01200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GWR21_RS01210	COG1956	GAF domain-containing protein
GWR21_RS01215	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GWR21_RS01220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWR21_RS01240	COG0277	FAD linked oxidase domain protein
GWR21_RS01240	COG0247	lactate metabolic process
GWR21_RS01245	COG1801	Protein of unknown function DUF72
GWR21_RS01250	COG0297	glycogen (starch) synthase activity
GWR21_RS01255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GWR21_RS01260	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GWR21_RS01265	COG1289	transmembrane transporter activity
GWR21_RS01270	COG1196	nuclear chromosome segregation
GWR21_RS01280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GWR21_RS01300	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GWR21_RS01315	COG3118	belongs to the thioredoxin family
GWR21_RS01325	COG0791	NLP P60 protein
GWR21_RS01340	COG1216	Glycosyl transferase, family 2
GWR21_RS01380	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWR21_RS01400	COG0477	Major facilitator Superfamily
GWR21_RS01450	COG0456	acetyltransferase
GWR21_RS01460	COG1131	(ABC) transporter
GWR21_RS01475	COG0673	inositol 2-dehydrogenase activity
GWR21_RS01505	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GWR21_RS01510	COG0300	oxidoreductase activity
GWR21_RS01585	COG4771	TonB-dependent receptor
GWR21_RS01595	COG3118	belongs to the thioredoxin family
GWR21_RS01660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWR21_RS01700	COG3851	Histidine kinase
GWR21_RS01715	COG4948	Mandelate Racemase Muconate Lactonizing
GWR21_RS01720	COG1070	Carbohydrate kinase
GWR21_RS01730	COG1629	transport
GWR21_RS01730	COG4206	TonB-dependent receptor
GWR21_RS01740	COG0129	dihydroxy-acid dehydratase activity
GWR21_RS01755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWR21_RS01780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWR21_RS01810	COG1484	DNA-dependent DNA replication
GWR21_RS01815	COG4584	PFAM Integrase catalytic
GWR21_RS01925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GWR21_RS01945	COG1629	transport
GWR21_RS01945	COG4206	TonB-dependent receptor
GWR21_RS01960	COG1131	(ABC) transporter
GWR21_RS01970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWR21_RS01975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWR21_RS01980	COG0612	Peptidase, M16
GWR21_RS01985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWR21_RS01990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWR21_RS02000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GWR21_RS02070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWR21_RS02075	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GWR21_RS02080	COG0402	S-adenosylhomocysteine deaminase activity
GWR21_RS02125	COG1595	DNA-templated transcription, initiation
GWR21_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS02165	COG2070	2-Nitropropane dioxygenase
GWR21_RS02180	COG2267	carboxylic ester hydrolase activity
GWR21_RS02190	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GWR21_RS02190	COG2755	lipolytic protein G-D-S-L family
GWR21_RS02195	COG3292	Two component regulator propeller
GWR21_RS02195	COG2205	protein histidine kinase activity
GWR21_RS02195	COG0745	RESPONSE REGULATOR receiver
GWR21_RS02195	COG3292	Two component regulator propeller
GWR21_RS02195	COG2205	protein histidine kinase activity
GWR21_RS02195	COG0745	RESPONSE REGULATOR receiver
GWR21_RS02200	COG4771	TonB-dependent receptor
GWR21_RS02250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS02260	COG1629	transport
GWR21_RS02380	COG1629	transport
GWR21_RS02420	COG4771	TonB-dependent receptor
GWR21_RS02430	COG1940	carbohydrate kinase activity
GWR21_RS02465	COG1629	transport
GWR21_RS02470	COG0702	epimerase
GWR21_RS02495	COG1629	transport
GWR21_RS02495	COG4206	TonB-dependent receptor
GWR21_RS02510	COG1136	(ABC) transporter
GWR21_RS02510	COG0577	efflux transmembrane transporter activity
GWR21_RS02540	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GWR21_RS02545	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
GWR21_RS02565	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GWR21_RS02590	COG1648	precorrin-2 dehydrogenase activity
GWR21_RS02590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWR21_RS02625	COG1492	cobalamin metabolic process
GWR21_RS02630	COG1797	cobyrinic acid a,c-diamide synthase activity
GWR21_RS02640	COG0110	maltose O-acetyltransferase activity
GWR21_RS02645	COG1064	alcohol dehydrogenase
GWR21_RS02675	COG0300	oxidoreductase activity
GWR21_RS02680	COG0028	Belongs to the TPP enzyme family
GWR21_RS02695	COG3384	dioxygenase
GWR21_RS02715	COG3250	beta-galactosidase activity
GWR21_RS02720	COG2814	Major facilitator Superfamily
GWR21_RS02755	COG4206	TonB-dependent receptor
GWR21_RS02755	COG1629	transport
GWR21_RS02775	COG1201	RNA secondary structure unwinding
GWR21_RS02820	COG1858	cytochrome C peroxidase
GWR21_RS02825	COG2197	response regulator
GWR21_RS02835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWR21_RS02850	COG4977	sequence-specific DNA binding
GWR21_RS02850	COG1917	Cupin 2, conserved barrel domain protein
GWR21_RS02855	COG1012	belongs to the aldehyde dehydrogenase family
GWR21_RS02910	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWR21_RS02920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWR21_RS02925	COG2005	Transcriptional regulator
GWR21_RS02955	COG4895	conserved protein (DUF2196)
GWR21_RS02960	COG4251	negative regulation of phosphorylation
GWR21_RS03085	COG0628	permease
GWR21_RS03090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS03095	COG2197	response regulator
GWR21_RS03140	COG1253	flavin adenine dinucleotide binding
GWR21_RS03145	COG1733	regulation of RNA biosynthetic process
GWR21_RS03150	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS03165	COG4206	TonB-dependent receptor
GWR21_RS03165	COG1629	transport
GWR21_RS03175	COG4251	negative regulation of phosphorylation
GWR21_RS03190	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GWR21_RS03210	COG2204	response regulator
GWR21_RS03220	COG2204	response regulator
GWR21_RS03225	COG0513	Belongs to the DEAD box helicase family
GWR21_RS03245	COG2885	chlorophyll binding
GWR21_RS03255	COG3537	Alpha-1,2-mannosidase
GWR21_RS03270	COG0745	RESPONSE REGULATOR receiver
GWR21_RS03295	COG1309	transcriptional regulator
GWR21_RS03305	COG0626	cystathionine gamma-synthase activity
GWR21_RS03310	COG0402	S-adenosylhomocysteine deaminase activity
GWR21_RS03320	COG1301	dicarboxylic acid transport
GWR21_RS03325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWR21_RS03345	COG2160	L-arabinose isomerase activity
GWR21_RS03355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GWR21_RS03370	COG0542	response to heat
GWR21_RS03375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GWR21_RS03385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWR21_RS03390	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS03395	COG1733	regulation of RNA biosynthetic process
GWR21_RS03405	COG4682	membrane
GWR21_RS03420	COG0590	tRNA wobble adenosine to inosine editing
GWR21_RS03430	COG5002	protein histidine kinase activity
GWR21_RS03430	COG0784	Response regulator, receiver
GWR21_RS03445	COG3279	Response regulator of the LytR AlgR family
GWR21_RS03460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWR21_RS03475	COG0671	phosphoesterase, PA-phosphatase related
GWR21_RS03480	COG0038	chloride channel
GWR21_RS03485	COG0604	alcohol dehydrogenase
GWR21_RS03490	COG0667	Aldo Keto reductase
GWR21_RS03500	COG3387	PFAM Glycoside hydrolase 15-related
GWR21_RS03540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWR21_RS03550	COG0481	GTPase activity
GWR21_RS03565	COG0792	nuclease activity
GWR21_RS03575	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GWR21_RS03590	COG0747	negative chemotaxis
GWR21_RS03620	COG0277	FAD linked oxidase domain protein
GWR21_RS03625	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWR21_RS03635	COG0697	spore germination
GWR21_RS03650	COG1515	deoxyribonuclease V activity
GWR21_RS03680	COG1132	(ABC) transporter
GWR21_RS03685	COG1607	acyl-coa hydrolase
GWR21_RS03710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWR21_RS03715	COG2321	neutral zinc metallopeptidase
GWR21_RS03725	COG2205	protein histidine kinase activity
GWR21_RS03805	COG2124	cytochrome p450
GWR21_RS03810	COG2198	Histidine kinase
GWR21_RS03810	COG0784	Response regulator, receiver
GWR21_RS03810	COG5002	protein histidine kinase activity
GWR21_RS03830	COG2205	protein histidine kinase activity
GWR21_RS03835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWR21_RS03850	COG1902	pentaerythritol trinitrate reductase activity
GWR21_RS03855	COG1278	Cold shock
GWR21_RS03940	COG1741	Belongs to the pirin family
GWR21_RS03945	COG2860	membrane
GWR21_RS03980	COG0561	phosphatase activity
GWR21_RS03990	COG3831	ATPase activity
GWR21_RS03990	COG4884	unkown
GWR21_RS04025	COG4221	oxidoreductase activity
GWR21_RS04050	COG2194	sulfuric ester hydrolase activity
GWR21_RS04105	COG0328	RNA-DNA hybrid ribonuclease activity
GWR21_RS04185	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GWR21_RS04200	COG0702	epimerase
GWR21_RS04205	COG1629	transport
GWR21_RS04205	COG4206	TonB-dependent receptor
GWR21_RS04230	COG0673	inositol 2-dehydrogenase activity
GWR21_RS04250	COG2130	NADP-dependent
GWR21_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS04260	COG3321	synthase
GWR21_RS04260	COG0604	alcohol dehydrogenase
GWR21_RS04270	COG3604	Transcriptional regulator
GWR21_RS04275	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GWR21_RS04295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWR21_RS04305	COG2989	Protein conserved in bacteria
GWR21_RS04385	COG1388	LysM domain
GWR21_RS04385	COG3858	chitin binding
GWR21_RS04410	COG0517	IMP dehydrogenase activity
GWR21_RS04415	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWR21_RS04420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWR21_RS04425	COG0649	NAD binding
GWR21_RS04425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWR21_RS04440	COG1034	ATP synthesis coupled electron transport
GWR21_RS04445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWR21_RS04450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWR21_RS04460	COG0713	ATP synthesis coupled electron transport
GWR21_RS04465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWR21_RS04475	COG1007	ATP synthesis coupled electron transport
GWR21_RS04500	COG4771	TonB-dependent receptor
GWR21_RS04525	COG3250	beta-galactosidase activity
GWR21_RS04535	COG0251	oxidation-reduction process
GWR21_RS04550	COG1136	(ABC) transporter
GWR21_RS04600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWR21_RS04600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWR21_RS04640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWR21_RS04655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GWR21_RS04665	COG1366	Belongs to the anti-sigma-factor antagonist family
GWR21_RS04670	COG1366	Belongs to the anti-sigma-factor antagonist family
GWR21_RS04675	COG2172	sigma factor antagonist activity
GWR21_RS04685	COG4251	negative regulation of phosphorylation
GWR21_RS04690	COG3292	Two component regulator propeller
GWR21_RS04690	COG2205	protein histidine kinase activity
GWR21_RS04690	COG0745	RESPONSE REGULATOR receiver
GWR21_RS04695	COG0037	tRNA processing
GWR21_RS04705	COG2086	electron transfer activity
GWR21_RS04710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GWR21_RS04720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GWR21_RS04730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GWR21_RS04735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GWR21_RS04745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWR21_RS04750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWR21_RS04755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GWR21_RS04760	COG4206	TonB-dependent receptor
GWR21_RS04760	COG1629	transport
GWR21_RS04780	COG3292	Two component regulator propeller
GWR21_RS04780	COG2205	protein histidine kinase activity
GWR21_RS04780	COG0745	RESPONSE REGULATOR receiver
GWR21_RS04785	COG0745	RESPONSE REGULATOR receiver
GWR21_RS04790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GWR21_RS04795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GWR21_RS04805	COG0488	(ABC) transporter
GWR21_RS04810	COG0745	RESPONSE REGULATOR receiver
GWR21_RS04815	COG2205	protein histidine kinase activity
GWR21_RS04830	COG1054	Belongs to the UPF0176 family
GWR21_RS04860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWR21_RS04875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWR21_RS04885	COG4206	TonB-dependent receptor
GWR21_RS04885	COG1629	transport
GWR21_RS04900	COG0012	GTP binding
GWR21_RS04905	COG0700	Nucleoside recognition
GWR21_RS04910	COG2855	membrane
GWR21_RS04920	COG3153	acetyltransferase
GWR21_RS04920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWR21_RS04930	COG0110	maltose O-acetyltransferase activity
GWR21_RS04955	COG0367	asparagine synthase
GWR21_RS04960	COG1216	Glycosyl transferase, family 2
GWR21_RS04970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWR21_RS04975	COG0745	RESPONSE REGULATOR receiver
GWR21_RS05025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GWR21_RS05030	COG0297	glycogen (starch) synthase activity
GWR21_RS05035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GWR21_RS05040	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GWR21_RS05050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWR21_RS05055	COG0248	Ppx GppA phosphatase
GWR21_RS05060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWR21_RS05070	COG1012	belongs to the aldehyde dehydrogenase family
GWR21_RS05100	COG0531	amino acid
GWR21_RS05105	COG0142	geranyltranstransferase activity
GWR21_RS05110	COG0557	exoribonuclease II activity
GWR21_RS05115	COG1663	tetraacyldisaccharide 4'-kinase activity
GWR21_RS05120	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWR21_RS05125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GWR21_RS05135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWR21_RS05140	COG0191	fructose-bisphosphate aldolase activity
GWR21_RS05145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GWR21_RS05150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GWR21_RS05180	COG2353	YceI-like domain
GWR21_RS05190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWR21_RS05195	COG1733	regulation of RNA biosynthetic process
GWR21_RS05200	COG0300	oxidoreductase activity
GWR21_RS05225	COG1846	Transcriptional regulator
GWR21_RS05225	COG0456	acetyltransferase
GWR21_RS05245	COG4771	TonB-dependent receptor
GWR21_RS05260	COG2201	protein-glutamate methylesterase activity
GWR21_RS05280	COG0523	cobalamin synthesis protein
GWR21_RS05285	COG1404	Belongs to the peptidase S8 family
GWR21_RS05290	COG3279	Response regulator of the LytR AlgR family
GWR21_RS05295	COG3275	phosphorelay sensor kinase activity
GWR21_RS05320	COG2204	response regulator
GWR21_RS05325	COG1764	response to oxidative stress
GWR21_RS05345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GWR21_RS05350	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GWR21_RS05355	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GWR21_RS05365	COG2205	protein histidine kinase activity
GWR21_RS05370	COG5002	protein histidine kinase activity
GWR21_RS05400	COG1629	transport
GWR21_RS05405	COG0702	epimerase
GWR21_RS05415	COG0457	Tetratricopeptide repeat
GWR21_RS05425	COG2814	Major facilitator Superfamily
GWR21_RS05445	COG0702	epimerase
GWR21_RS05450	COG4771	TonB-dependent receptor
GWR21_RS05510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWR21_RS05515	COG1309	transcriptional regulator
GWR21_RS05550	COG1858	cytochrome C peroxidase
GWR21_RS05565	COG1629	transport
GWR21_RS05590	COG4771	TonB-dependent receptor
GWR21_RS05600	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GWR21_RS05605	COG0657	acetylesterase activity
GWR21_RS05605	COG2755	lipolytic protein G-D-S-L family
GWR21_RS05610	COG3291	Pkd domain containing protein
GWR21_RS05620	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
GWR21_RS05625	COG0028	Belongs to the TPP enzyme family
GWR21_RS05645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWR21_RS05655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWR21_RS05675	COG2814	Major facilitator Superfamily
GWR21_RS05725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS05730	COG2755	lipolytic protein G-D-S-L family
GWR21_RS05770	COG4251	negative regulation of phosphorylation
GWR21_RS05800	COG0720	synthase
GWR21_RS05850	COG1477	protein flavinylation
GWR21_RS05855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS05885	COG1733	regulation of RNA biosynthetic process
GWR21_RS05915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWR21_RS06015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWR21_RS06020	COG2226	methyltransferase
GWR21_RS06035	COG2133	pyrroloquinoline quinone binding
GWR21_RS06040	COG3291	Pkd domain containing protein
GWR21_RS06075	COG0583	DNA-binding transcription factor activity
GWR21_RS06095	COG0564	pseudouridine synthase activity
GWR21_RS06100	COG4106	trans-aconitate 2-methyltransferase activity
GWR21_RS06120	COG5520	Belongs to the glycosyl hydrolase 30 family
GWR21_RS06170	COG2010	Cytochrome c
GWR21_RS06170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWR21_RS06190	COG5520	Belongs to the glycosyl hydrolase 30 family
GWR21_RS06190	COG4447	cellulose binding
GWR21_RS06190	COG3291	Pkd domain containing protein
GWR21_RS06220	COG3158	transport of potassium into the cell
GWR21_RS06280	COG3279	Response regulator of the LytR AlgR family
GWR21_RS06305	COG0563	adenylate kinase activity
GWR21_RS06320	COG2226	methyltransferase
GWR21_RS06340	COG3250	beta-galactosidase activity
GWR21_RS06350	COG4771	TonB-dependent receptor
GWR21_RS06355	COG1609	Transcriptional regulator
GWR21_RS06395	COG1234	tRNA 3'-trailer cleavage
GWR21_RS06425	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GWR21_RS06440	COG0346	lactoylglutathione lyase activity
GWR21_RS06445	COG1349	DNA-binding transcription factor activity
GWR21_RS06475	COG1733	regulation of RNA biosynthetic process
GWR21_RS06480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWR21_RS06490	COG2814	Major facilitator Superfamily
GWR21_RS06525	COG0519	Catalyzes the synthesis of GMP from XMP
GWR21_RS06535	COG0493	'glutamate synthase
GWR21_RS06535	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWR21_RS06550	COG1953	Uracil, thiamine, allantoin
GWR21_RS06555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GWR21_RS06560	COG1012	belongs to the aldehyde dehydrogenase family
GWR21_RS06580	COG1902	pentaerythritol trinitrate reductase activity
GWR21_RS06605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWR21_RS06620	COG2814	Major facilitator Superfamily
GWR21_RS06625	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GWR21_RS06635	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS06655	COG0587	DNA-directed DNA polymerase activity
GWR21_RS06665	COG0708	Exodeoxyribonuclease III
GWR21_RS06690	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GWR21_RS06695	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWR21_RS06700	COG0577	efflux transmembrane transporter activity
GWR21_RS06700	COG1136	(ABC) transporter
GWR21_RS06705	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GWR21_RS06715	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GWR21_RS06730	COG2207	Transcriptional regulator
GWR21_RS06745	COG1247	-acetyltransferase
GWR21_RS06760	COG0431	NADPH-dependent FMN reductase
GWR21_RS06765	COG0316	Belongs to the HesB IscA family
GWR21_RS06770	COG0719	Fe-S assembly protein
GWR21_RS06775	COG0396	ATPase activity
GWR21_RS06780	COG0719	Fe-S assembly protein
GWR21_RS06790	COG2166	iron-sulfur cluster assembly
GWR21_RS06795	COG2151	metal-sulfur cluster biosynthetic enzyme
GWR21_RS06840	COG4251	negative regulation of phosphorylation
GWR21_RS06850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWR21_RS06865	COG4651	solute:proton antiporter activity
GWR21_RS06865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWR21_RS06880	COG4221	oxidoreductase activity
GWR21_RS06890	COG1733	regulation of RNA biosynthetic process
GWR21_RS06895	COG2353	YceI-like domain
GWR21_RS06910	COG1960	acyl-CoA dehydrogenase activity
GWR21_RS06920	COG2205	protein histidine kinase activity
GWR21_RS06940	COG1063	alcohol dehydrogenase
GWR21_RS06950	COG1127	ABC transporter
GWR21_RS06955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWR21_RS06970	COG2186	Transcriptional regulator
GWR21_RS06975	COG0730	response to heat
GWR21_RS06985	COG1132	(ABC) transporter
GWR21_RS06990	COG1132	(ABC) transporter
GWR21_RS06995	COG0300	oxidoreductase activity
GWR21_RS07025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS07060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWR21_RS07065	COG2226	methyltransferase
GWR21_RS07080	COG0604	alcohol dehydrogenase
GWR21_RS07085	COG3340	Belongs to the peptidase S51 family
GWR21_RS07135	COG0577	efflux transmembrane transporter activity
GWR21_RS07145	COG1621	beta-fructofuranosidase activity
GWR21_RS07160	COG1473	amidohydrolase
GWR21_RS07245	COG0300	oxidoreductase activity
GWR21_RS07290	COG0488	(ABC) transporter
GWR21_RS07300	COG3511	phospholipase C
GWR21_RS07320	COG1187	pseudouridine synthase activity
GWR21_RS07330	COG0724	RNA recognition motif
GWR21_RS07345	COG1132	(ABC) transporter
GWR21_RS07370	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GWR21_RS07380	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS07390	COG1215	transferase activity, transferring glycosyl groups
GWR21_RS07405	COG4771	TonB-dependent receptor
GWR21_RS07425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWR21_RS07435	COG0463	Glycosyl transferase, family 2
GWR21_RS07460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GWR21_RS07495	COG2197	response regulator
GWR21_RS07530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GWR21_RS07540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWR21_RS07550	COG0552	protein localization to endoplasmic reticulum
GWR21_RS07560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GWR21_RS07565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GWR21_RS07570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWR21_RS07575	COG0450	alkyl hydroperoxide reductase
GWR21_RS07580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GWR21_RS07600	COG1138	Cytochrome C-type biogenesis protein
GWR21_RS07610	COG0010	Belongs to the arginase family
GWR21_RS07625	COG2814	Major facilitator Superfamily
GWR21_RS07625	COG0477	Major facilitator Superfamily
GWR21_RS07640	COG0285	dihydrofolate synthase activity
GWR21_RS07645	COG0494	nUDIX hydrolase
GWR21_RS07650	COG2318	DinB family
GWR21_RS07655	COG1131	(ABC) transporter
GWR21_RS07665	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GWR21_RS07670	COG0527	aspartate kinase activity
GWR21_RS07685	COG0517	IMP dehydrogenase activity
GWR21_RS07685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GWR21_RS07695	COG4948	Mandelate Racemase Muconate Lactonizing
GWR21_RS07730	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GWR21_RS07735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS07740	COG1309	transcriptional regulator
GWR21_RS07755	COG0667	Aldo Keto reductase
GWR21_RS07770	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GWR21_RS07775	COG0527	aspartate kinase activity
GWR21_RS07775	COG0460	homoserine dehydrogenase
GWR21_RS07780	COG0083	homoserine kinase activity
GWR21_RS07785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWR21_RS07795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWR21_RS07800	COG2198	Histidine kinase
GWR21_RS07800	COG0784	Response regulator, receiver
GWR21_RS07800	COG0643	Histidine kinase
GWR21_RS07805	COG4251	negative regulation of phosphorylation
GWR21_RS07810	COG1702	phosphate starvation-inducible protein PhoH
GWR21_RS07865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWR21_RS07885	COG0247	lactate metabolic process
GWR21_RS07890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWR21_RS07900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GWR21_RS07905	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWR21_RS07935	COG1595	DNA-templated transcription, initiation
GWR21_RS07940	COG0601	transmembrane transport
GWR21_RS07950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWR21_RS07955	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GWR21_RS07960	COG0545	Peptidyl-prolyl cis-trans isomerase
GWR21_RS07970	COG0105	UTP biosynthetic process
GWR21_RS07975	COG4974	Belongs to the 'phage' integrase family
GWR21_RS08050	COG4771	TonB-dependent receptor
GWR21_RS08055	COG0540	Belongs to the ATCase OTCase family
GWR21_RS08060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GWR21_RS08065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWR21_RS08070	COG1012	belongs to the aldehyde dehydrogenase family
GWR21_RS08085	COG0166	Belongs to the GPI family
GWR21_RS08095	COG1132	(ABC) transporter
GWR21_RS08100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWR21_RS08105	COG1199	ATP-dependent helicase activity
GWR21_RS08105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWR21_RS08115	COG1309	transcriptional regulator
GWR21_RS08125	COG1904	glucuronate isomerase
GWR21_RS08130	COG2721	sulfolactate sulfo-lyase activity
GWR21_RS08135	COG0246	Mannitol dehydrogenase
GWR21_RS08140	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GWR21_RS08145	COG2755	lipolytic protein G-D-S-L family
GWR21_RS08150	COG0702	epimerase
GWR21_RS08155	COG1629	transport
GWR21_RS08165	COG1609	Transcriptional regulator
GWR21_RS08170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWR21_RS08210	COG0561	phosphatase activity
GWR21_RS08215	COG1629	transport
GWR21_RS08240	COG2706	6-phosphogluconolactonase activity
GWR21_RS08250	COG0432	Pfam Uncharacterised protein family UPF0047
GWR21_RS08260	COG3852	Histidine kinase
GWR21_RS08280	COG1073	alpha beta
GWR21_RS08305	COG0745	RESPONSE REGULATOR receiver
GWR21_RS08305	COG2205	protein histidine kinase activity
GWR21_RS08305	COG3292	Two component regulator propeller
GWR21_RS08325	COG1501	Belongs to the glycosyl hydrolase 31 family
GWR21_RS08330	COG1629	transport
GWR21_RS08360	COG2205	protein histidine kinase activity
GWR21_RS08390	COG1629	transport
GWR21_RS08410	COG0784	Response regulator, receiver
GWR21_RS08410	COG2205	protein histidine kinase activity
GWR21_RS08435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWR21_RS08440	COG3938	Belongs to the proline racemase family
GWR21_RS08470	COG0745	RESPONSE REGULATOR receiver
GWR21_RS08475	COG2308	Evidence 4 Homologs of previously reported genes of
GWR21_RS08485	COG1305	Transglutaminase-like
GWR21_RS08490	COG0531	amino acid
GWR21_RS08500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWR21_RS08510	COG0667	Aldo Keto reductase
GWR21_RS08540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWR21_RS08545	COG2198	Histidine kinase
GWR21_RS08545	COG0643	Histidine kinase
GWR21_RS08545	COG0784	Response regulator, receiver
GWR21_RS08555	COG3275	phosphorelay sensor kinase activity
GWR21_RS08560	COG3279	Response regulator of the LytR AlgR family
GWR21_RS08595	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GWR21_RS08600	COG1917	Cupin 2, conserved barrel domain protein
GWR21_RS08600	COG2169	Transcriptional regulator
GWR21_RS08650	COG1233	COG1233 Phytoene dehydrogenase and related
GWR21_RS08655	COG0789	Transcriptional regulator
GWR21_RS08660	COG0604	alcohol dehydrogenase
GWR21_RS08660	COG3321	synthase
GWR21_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS08665	COG2201	protein-glutamate methylesterase activity
GWR21_RS08675	COG2207	Transcriptional regulator
GWR21_RS08710	COG1678	Uncharacterized ACR, COG1678
GWR21_RS08715	COG1733	regulation of RNA biosynthetic process
GWR21_RS08740	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWR21_RS08765	COG4771	TonB-dependent receptor
GWR21_RS08780	COG3604	Transcriptional regulator
GWR21_RS08785	COG3604	Transcriptional regulator
GWR21_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS08835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWR21_RS08850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWR21_RS08890	COG0604	alcohol dehydrogenase
GWR21_RS08895	COG4977	sequence-specific DNA binding
GWR21_RS08915	COG1506	peptidase
GWR21_RS08970	COG0024	Methionine aminopeptidase
GWR21_RS09025	COG3275	phosphorelay sensor kinase activity
GWR21_RS09035	COG3842	ATPase activity
GWR21_RS09065	COG3201	nicotinamide mononucleotide transporter
GWR21_RS09085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS09140	COG1082	Xylose isomerase domain protein TIM barrel
GWR21_RS09145	COG0366	Alpha amylase catalytic
GWR21_RS09160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWR21_RS09170	COG2197	response regulator
GWR21_RS09175	COG0671	phosphoesterase, PA-phosphatase related
GWR21_RS09190	COG2346	COG2346, Truncated hemoglobins
GWR21_RS09205	COG2010	Cytochrome c
GWR21_RS09210	COG3278	Belongs to the heme-copper respiratory oxidase family
GWR21_RS09215	COG1959	2 iron, 2 sulfur cluster binding
GWR21_RS09220	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GWR21_RS09240	COG3408	Glycogen debranching enzyme
GWR21_RS09240	COG3119	arylsulfatase activity
GWR21_RS09270	COG0025	NhaP-type Na H and K H
GWR21_RS09275	COG0339	signal peptide processing
GWR21_RS09295	COG1858	cytochrome C peroxidase
GWR21_RS09370	COG0596	Alpha beta hydrolase
GWR21_RS09430	COG4771	TonB-dependent receptor
GWR21_RS09435	COG0561	phosphatase activity
GWR21_RS09460	COG0616	signal peptide processing
GWR21_RS09465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWR21_RS09475	COG2081	HI0933 family
GWR21_RS09500	COG3685	Protein conserved in bacteria
GWR21_RS09505	COG1881	PFAM PEBP family protein
GWR21_RS09510	COG1051	belongs to the nudix hydrolase family
GWR21_RS09610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWR21_RS09615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWR21_RS09620	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GWR21_RS09625	COG2181	nitrate reductase activity
GWR21_RS09625	COG0247	lactate metabolic process
GWR21_RS09630	COG0247	lactate metabolic process
GWR21_RS09630	COG2181	nitrate reductase activity
GWR21_RS09685	COG3344	reverse transcriptase
GWR21_RS09740	COG3179	chitinase
GWR21_RS09790	COG3851	Histidine kinase
GWR21_RS09795	COG2197	response regulator
GWR21_RS09800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWR21_RS09805	COG2204	response regulator
GWR21_RS09825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWR21_RS09830	COG1295	ribonuclease BN
GWR21_RS09855	COG0405	Gamma-glutamyltransferase
GWR21_RS09870	COG0156	8-amino-7-oxononanoate synthase activity
GWR21_RS09885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWR21_RS09885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWR21_RS09920	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GWR21_RS09945	COG0515	serine threonine protein kinase
GWR21_RS09945	COG2815	serine threonine protein kinase
GWR21_RS09950	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWR21_RS09955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWR21_RS09965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWR21_RS09970	COG3279	Response regulator of the LytR AlgR family
GWR21_RS09980	COG0442	prolyl-tRNA aminoacylation
GWR21_RS09995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GWR21_RS10005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GWR21_RS10005	COG0617	tRNA 3'-terminal CCA addition
GWR21_RS10005	COG0517	IMP dehydrogenase activity
GWR21_RS10010	COG0009	L-threonylcarbamoyladenylate synthase
GWR21_RS10020	COG2171	N-acyltransferase activity
GWR21_RS10035	COG5002	protein histidine kinase activity
GWR21_RS10080	COG2390	Transcriptional regulator
GWR21_RS10080	COG4584	PFAM Integrase catalytic
GWR21_RS10085	COG1484	DNA-dependent DNA replication
GWR21_RS10130	COG2801	Transposase and inactivated derivatives
GWR21_RS10180	COG5002	protein histidine kinase activity
GWR21_RS10190	COG1733	regulation of RNA biosynthetic process
GWR21_RS10205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWR21_RS10210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWR21_RS10240	COG1131	(ABC) transporter
GWR21_RS10265	COG4771	TonB-dependent receptor
GWR21_RS10270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GWR21_RS10280	COG2207	Transcriptional regulator
GWR21_RS10280	COG4753	response regulator
GWR21_RS10295	COG4206	TonB-dependent receptor
GWR21_RS10310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWR21_RS10315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWR21_RS10360	COG3275	phosphorelay sensor kinase activity
GWR21_RS10370	COG2207	Transcriptional regulator
GWR21_RS10380	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWR21_RS10385	COG0673	inositol 2-dehydrogenase activity
GWR21_RS10390	COG0577	efflux transmembrane transporter activity
GWR21_RS10410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWR21_RS10420	COG4977	sequence-specific DNA binding
GWR21_RS10455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWR21_RS10460	COG2910	NAD(P)H-binding
GWR21_RS10465	COG2169	Transcriptional regulator
GWR21_RS10465	COG1917	Cupin 2, conserved barrel domain protein
GWR21_RS10475	COG2226	methyltransferase
GWR21_RS10480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWR21_RS10485	COG0798	PFAM Bile acid sodium symporter
GWR21_RS10495	COG0300	oxidoreductase activity
GWR21_RS10540	COG4771	TonB-dependent receptor
GWR21_RS10570	COG4206	TonB-dependent receptor
GWR21_RS10570	COG1629	transport
GWR21_RS10590	COG3940	Belongs to the glycosyl hydrolase 43 family
GWR21_RS10620	COG4221	oxidoreductase activity
GWR21_RS10630	COG3292	Two component regulator propeller
GWR21_RS10630	COG0745	RESPONSE REGULATOR receiver
GWR21_RS10630	COG2205	protein histidine kinase activity
GWR21_RS10635	COG1629	transport
GWR21_RS10635	COG4206	TonB-dependent receptor
GWR21_RS10660	COG3250	beta-galactosidase activity
GWR21_RS10670	COG3250	beta-galactosidase activity
GWR21_RS10720	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWR21_RS10755	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWR21_RS10755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWR21_RS10760	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GWR21_RS10800	COG1254	Belongs to the acylphosphatase family
GWR21_RS10810	COG0149	triose-phosphate isomerase activity
GWR21_RS10820	COG0254	rRNA binding
GWR21_RS10825	COG1666	GTP binding
GWR21_RS10860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GWR21_RS10880	COG1166	arginine decarboxylase activity
GWR21_RS10900	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWR21_RS10915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GWR21_RS10930	COG0534	Mate efflux family protein
GWR21_RS10945	COG0492	ferredoxin-NADP+ reductase activity
GWR21_RS10950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWR21_RS10960	COG0525	valine-tRNA ligase activity
GWR21_RS10975	COG1760	l-serine dehydratase
GWR21_RS10980	COG0545	Peptidyl-prolyl cis-trans isomerase
GWR21_RS10985	COG0545	Peptidyl-prolyl cis-trans isomerase
GWR21_RS10990	COG0459	protein refolding
GWR21_RS10995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWR21_RS11000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GWR21_RS11020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWR21_RS11025	COG4124	Belongs to the glycosyl hydrolase 26 family
GWR21_RS11025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GWR21_RS11030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWR21_RS11045	COG0436	Aminotransferase
GWR21_RS11060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWR21_RS11060	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWR21_RS11065	COG0500	methyltransferase
GWR21_RS11075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWR21_RS11085	COG1674	ftsk spoiiie
GWR21_RS11095	COG2363	Small membrane protein
GWR21_RS11100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GWR21_RS11110	COG0717	Belongs to the dCTP deaminase family
GWR21_RS11145	COG2755	lipolytic protein G-D-S-L family
GWR21_RS11145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GWR21_RS11200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWR21_RS11205	COG1960	acyl-CoA dehydrogenase activity
GWR21_RS11210	COG0010	Belongs to the arginase family
GWR21_RS11225	COG3001	Fructosamine kinase
GWR21_RS11230	COG2205	protein histidine kinase activity
GWR21_RS11230	COG0784	Response regulator, receiver
GWR21_RS11240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GWR21_RS11245	COG0416	fatty acid biosynthetic process
GWR21_RS11250	COG5000	phosphorelay sensor kinase activity
GWR21_RS11255	COG3956	TIGRFAM MazG family protein
GWR21_RS11260	COG2183	response to ionizing radiation
GWR21_RS11270	COG1024	Enoyl-CoA hydratase
GWR21_RS11340	COG0071	Belongs to the small heat shock protein (HSP20) family
GWR21_RS11385	COG0628	permease
GWR21_RS11420	COG3534	alpha-L-arabinofuranosidase
GWR21_RS11430	COG0561	phosphatase activity
GWR21_RS11435	COG4771	TonB-dependent receptor
GWR21_RS11440	COG2205	protein histidine kinase activity
GWR21_RS11440	COG3292	Two component regulator propeller
GWR21_RS11440	COG0745	RESPONSE REGULATOR receiver
GWR21_RS11490	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS11505	COG3321	synthase
GWR21_RS11505	COG0604	alcohol dehydrogenase
GWR21_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS11590	COG3285	dna ligase
GWR21_RS11590	COG1793	dna ligase
GWR21_RS11600	COG3279	Response regulator of the LytR AlgR family
GWR21_RS11605	COG3275	phosphorelay sensor kinase activity
GWR21_RS11665	COG4948	Mandelate Racemase Muconate Lactonizing
GWR21_RS11670	COG0443	Heat shock 70 kDa protein
GWR21_RS11685	COG0018	arginyl-trna synthetase
GWR21_RS11695	COG0295	cytidine deaminase activity
GWR21_RS11700	COG0681	Belongs to the peptidase S26 family
GWR21_RS11710	COG2204	response regulator
GWR21_RS11715	COG1045	serine acetyltransferase
GWR21_RS11725	COG0022	dehydrogenase e1 component
GWR21_RS11725	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWR21_RS11735	COG0183	Belongs to the thiolase family
GWR21_RS11755	COG0358	DNA primase activity
GWR21_RS11770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWR21_RS11815	COG0251	oxidation-reduction process
GWR21_RS11825	COG1629	transport
GWR21_RS11845	COG1515	deoxyribonuclease V activity
GWR21_RS11870	COG1360	Flagellar Motor Protein
GWR21_RS11880	COG4251	negative regulation of phosphorylation
GWR21_RS11890	COG0811	peptide transport
GWR21_RS11895	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWR21_RS11900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWR21_RS11910	COG1607	acyl-coa hydrolase
GWR21_RS11915	COG1047	Peptidyl-prolyl cis-trans
GWR21_RS11920	COG3876	Protein conserved in bacteria
GWR21_RS11925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWR21_RS11940	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GWR21_RS11945	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GWR21_RS11965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GWR21_RS11975	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GWR21_RS11980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GWR21_RS11985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWR21_RS11990	COG0181	hydroxymethylbilane synthase activity
GWR21_RS12000	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GWR21_RS12005	COG0408	coproporphyrinogen oxidase activity
GWR21_RS12010	COG0113	porphobilinogen synthase activity
GWR21_RS12015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWR21_RS12040	COG0583	DNA-binding transcription factor activity
GWR21_RS12050	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GWR21_RS12055	COG2264	protein methyltransferase activity
GWR21_RS12070	COG1185	polyribonucleotide nucleotidyltransferase activity
GWR21_RS12075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GWR21_RS12080	COG2884	Cell division ATP-binding protein ftsE
GWR21_RS12095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GWR21_RS12100	COG0196	riboflavin kinase activity
GWR21_RS12125	COG0488	(ABC) transporter
GWR21_RS12135	COG0288	reversible hydration of carbon dioxide
GWR21_RS12140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GWR21_RS12145	COG1770	oligopeptidase
GWR21_RS12150	COG0673	inositol 2-dehydrogenase activity
GWR21_RS12155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWR21_RS12160	COG1053	succinate dehydrogenase
GWR21_RS12175	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GWR21_RS12195	COG1160	GTP binding
GWR21_RS12200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWR21_RS12220	COG0165	Argininosuccinate lyase
GWR21_RS12225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWR21_RS12230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWR21_RS12240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWR21_RS12250	COG0137	argininosuccinate synthase activity
GWR21_RS12265	COG0673	inositol 2-dehydrogenase activity
GWR21_RS12280	COG1940	carbohydrate kinase activity
GWR21_RS12285	COG1446	asparaginase
GWR21_RS12290	COG3142	Participates in the control of copper homeostasis
GWR21_RS12300	COG4206	TonB-dependent receptor
GWR21_RS12300	COG1629	transport
GWR21_RS12320	COG0363	glucosamine-6-phosphate deaminase activity
GWR21_RS12325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWR21_RS12335	COG0492	ferredoxin-NADP+ reductase activity
GWR21_RS12340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GWR21_RS12345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWR21_RS12360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWR21_RS12390	COG0589	response to stress
GWR21_RS12390	COG0475	glutathione-regulated potassium exporter activity
GWR21_RS12400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GWR21_RS12415	COG1914	H( )-stimulated, divalent metal cation uptake system
GWR21_RS12420	COG3279	Response regulator of the LytR AlgR family
GWR21_RS12445	COG0538	isocitrate dehydrogenase activity
GWR21_RS12450	COG0538	isocitrate dehydrogenase activity
GWR21_RS12455	COG0667	Aldo Keto reductase
GWR21_RS12465	COG2989	Protein conserved in bacteria
GWR21_RS12500	COG0045	succinate-CoA ligase (ADP-forming) activity
GWR21_RS12545	COG2234	aminopeptidase activity
GWR21_RS12550	COG0706	membrane insertase activity
GWR21_RS12555	COG0504	CTP synthase activity
GWR21_RS12560	COG1607	acyl-coa hydrolase
GWR21_RS12565	COG1418	mRNA catabolic process
GWR21_RS12580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWR21_RS12585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWR21_RS12600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GWR21_RS12610	COG3275	phosphorelay sensor kinase activity
GWR21_RS12615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GWR21_RS12635	COG0542	response to heat
GWR21_RS12645	COG1234	tRNA 3'-trailer cleavage
GWR21_RS12650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWR21_RS12655	COG0825	malonyl-CoA metabolic process
GWR21_RS12675	COG0596	Alpha beta hydrolase
GWR21_RS12680	COG0596	Alpha beta hydrolase
GWR21_RS12690	COG0596	Alpha beta hydrolase
GWR21_RS12705	COG3604	Transcriptional regulator
GWR21_RS12710	COG0583	DNA-binding transcription factor activity
GWR21_RS12715	COG3920	Histidine kinase
GWR21_RS12755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWR21_RS12760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWR21_RS12780	COG4932	domain protein
GWR21_RS12780	COG5492	domain, Protein
GWR21_RS12790	COG1733	regulation of RNA biosynthetic process
GWR21_RS12795	COG1902	pentaerythritol trinitrate reductase activity
GWR21_RS12805	COG0596	Alpha beta hydrolase
GWR21_RS12815	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS12830	COG0667	Aldo Keto reductase
GWR21_RS12840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GWR21_RS12840	COG2755	lipolytic protein G-D-S-L family
GWR21_RS12855	COG0590	tRNA wobble adenosine to inosine editing
GWR21_RS12870	COG0604	alcohol dehydrogenase
GWR21_RS12930	COG4771	TonB-dependent receptor
GWR21_RS12950	COG1629	transport
GWR21_RS12980	COG0702	epimerase
GWR21_RS12985	COG1629	transport
GWR21_RS13005	COG4804	nuclease activity
GWR21_RS13010	COG1484	DNA-dependent DNA replication
GWR21_RS13015	COG4584	PFAM Integrase catalytic
GWR21_RS13015	COG2390	Transcriptional regulator
GWR21_RS13050	COG0730	response to heat
GWR21_RS13055	COG3655	Transcriptional regulator
GWR21_RS13070	COG0318	PFAM AMP-dependent synthetase and ligase
GWR21_RS13080	COG0534	Mate efflux family protein
GWR21_RS13085	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GWR21_RS13110	COG0076	glutamate decarboxylase activity
GWR21_RS13115	COG2175	clavaminate synthase activity
GWR21_RS13160	COG0667	Aldo Keto reductase
GWR21_RS13165	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWR21_RS13170	COG0583	DNA-binding transcription factor activity
GWR21_RS13220	COG3608	succinylglutamate desuccinylase aspartoacylase
GWR21_RS13220	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GWR21_RS13230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWR21_RS13240	COG3257	ureidoglycine aminohydrolase activity
GWR21_RS13250	COG2351	hydroxyisourate hydrolase activity
GWR21_RS13270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWR21_RS13275	COG3401	FG-GAP repeat protein
GWR21_RS13280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWR21_RS13320	COG4771	TonB-dependent receptor
GWR21_RS13345	COG1629	transport
GWR21_RS13350	COG0702	epimerase
GWR21_RS13370	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS13415	COG4771	TonB-dependent receptor
GWR21_RS13420	COG1349	DNA-binding transcription factor activity
GWR21_RS13425	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWR21_RS13430	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GWR21_RS13435	COG4145	pantothenate transmembrane transporter activity
GWR21_RS13440	COG5297	Belongs to the glycosyl hydrolase family 6
GWR21_RS13440	COG3250	beta-galactosidase activity
GWR21_RS13445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GWR21_RS13450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GWR21_RS13455	COG3537	Alpha-1,2-mannosidase
GWR21_RS13475	COG3851	Histidine kinase
GWR21_RS13480	COG2197	response regulator
GWR21_RS13490	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GWR21_RS13495	COG1609	Transcriptional regulator
GWR21_RS13500	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS13505	COG4677	pectinesterase activity
GWR21_RS13510	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GWR21_RS13515	COG2721	sulfolactate sulfo-lyase activity
GWR21_RS13535	COG1904	glucuronate isomerase
GWR21_RS13545	COG0482	sulfurtransferase activity
GWR21_RS13560	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWR21_RS13565	COG0567	Dehydrogenase, E1 component
GWR21_RS13570	COG0268	Binds directly to 16S ribosomal RNA
GWR21_RS13600	COG1131	(ABC) transporter
GWR21_RS13635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWR21_RS13635	COG0519	Catalyzes the synthesis of GMP from XMP
GWR21_RS13645	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWR21_RS13645	COG1793	dna ligase
GWR21_RS13650	COG1793	dna ligase
GWR21_RS13655	COG1522	sequence-specific DNA binding
GWR21_RS13665	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWR21_RS13685	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWR21_RS13700	COG5658	integral membrane protein
GWR21_RS13710	COG0587	DNA-directed DNA polymerase activity
GWR21_RS13720	COG0527	aspartate kinase activity
GWR21_RS13740	COG1629	transport
GWR21_RS13750	COG4771	TonB-dependent receptor
GWR21_RS13770	COG1428	Deoxynucleoside kinase
GWR21_RS13775	COG0180	Tryptophanyl-tRNA synthetase
GWR21_RS13780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWR21_RS13785	COG1136	(ABC) transporter
GWR21_RS13790	COG2096	Adenosyltransferase
GWR21_RS13795	COG1136	(ABC) transporter
GWR21_RS13805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GWR21_RS13810	COG0497	DNA recombination
GWR21_RS13825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWR21_RS13835	COG1054	Belongs to the UPF0176 family
GWR21_RS13865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWR21_RS13870	COG0484	heat shock protein binding
GWR21_RS13880	COG2304	oxidoreductase activity
GWR21_RS13885	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GWR21_RS13890	COG1388	LysM domain
GWR21_RS13890	COG1705	Flagellar rod assembly protein muramidase FlgJ
GWR21_RS13890	COG1388	LysM domain
GWR21_RS13890	COG1705	Flagellar rod assembly protein muramidase FlgJ
GWR21_RS13900	COG1611	Belongs to the LOG family
GWR21_RS13910	COG0277	FAD linked oxidase domain protein
GWR21_RS13920	COG3291	Pkd domain containing protein
GWR21_RS13925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWR21_RS13940	COG0343	queuine tRNA-ribosyltransferase activity
GWR21_RS13950	COG0357	Ribosomal RNA small subunit methyltransferase G
GWR21_RS13975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GWR21_RS13985	COG1183	phosphatidylcholine synthase activity
GWR21_RS13990	COG0006	proline dipeptidase activity
GWR21_RS13995	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GWR21_RS14000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWR21_RS14005	COG0602	queuosine metabolic process
GWR21_RS14010	COG2885	chlorophyll binding
GWR21_RS14020	COG0758	DNA mediated transformation
GWR21_RS14020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWR21_RS14025	COG0517	IMP dehydrogenase activity
GWR21_RS14025	COG0516	GMP reductase activity
GWR21_RS14030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GWR21_RS14050	COG4221	oxidoreductase activity
GWR21_RS14080	COG0632	four-way junction helicase activity
GWR21_RS14085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWR21_RS14095	COG0642	Histidine kinase
GWR21_RS14115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWR21_RS14125	COG0302	gtp cyclohydrolase
GWR21_RS14140	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GWR21_RS14145	COG0415	Belongs to the DNA photolyase family
GWR21_RS14150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWR21_RS14160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWR21_RS14190	COG2001	Belongs to the MraZ family
GWR21_RS14195	COG0275	rRNA processing
GWR21_RS14205	COG0768	penicillin binding
GWR21_RS14210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWR21_RS14215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GWR21_RS14220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWR21_RS14225	COG0772	Belongs to the SEDS family
GWR21_RS14230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWR21_RS14235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWR21_RS14250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWR21_RS14265	COG3158	transport of potassium into the cell
GWR21_RS14275	COG0142	geranyltranstransferase activity
GWR21_RS14280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWR21_RS14280	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GWR21_RS14290	COG0326	Molecular chaperone. Has ATPase activity
GWR21_RS14300	COG0360	Binds together with S18 to 16S ribosomal RNA
GWR21_RS14305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GWR21_RS14310	COG0359	binds to the 23S rRNA
GWR21_RS14340	COG2610	gluconate transmembrane transporter activity
GWR21_RS14345	COG1136	(ABC) transporter
GWR21_RS14345	COG0577	efflux transmembrane transporter activity
GWR21_RS14350	COG1609	Transcriptional regulator
GWR21_RS14360	COG1007	ATP synthesis coupled electron transport
GWR21_RS14365	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWR21_RS14370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWR21_RS14375	COG0713	ATP synthesis coupled electron transport
GWR21_RS14385	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWR21_RS14390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GWR21_RS14395	COG1034	ATP synthesis coupled electron transport
GWR21_RS14405	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GWR21_RS14410	COG0649	NAD binding
GWR21_RS14415	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWR21_RS14420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWR21_RS14425	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWR21_RS14440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWR21_RS14445	COG0124	histidyl-tRNA synthetase
GWR21_RS14460	COG0047	phosphoribosylformylglycinamidine synthase activity
GWR21_RS14480	COG2094	Belongs to the DNA glycosylase MPG family
GWR21_RS14500	COG1090	epimerase
GWR21_RS14505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWR21_RS14515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GWR21_RS14520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWR21_RS14545	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWR21_RS14555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWR21_RS14565	COG1131	(ABC) transporter
GWR21_RS14570	COG1024	Enoyl-CoA hydratase
GWR21_RS14570	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWR21_RS14585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWR21_RS14590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWR21_RS14590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWR21_RS14595	COG1619	proteins homologs of microcin C7 resistance protein MccF
GWR21_RS14600	COG2267	carboxylic ester hydrolase activity
GWR21_RS14605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWR21_RS14615	COG1678	Uncharacterized ACR, COG1678
GWR21_RS14625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GWR21_RS14655	COG1136	(ABC) transporter
GWR21_RS14655	COG0577	efflux transmembrane transporter activity
GWR21_RS14680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GWR21_RS14700	COG1090	epimerase
GWR21_RS14720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWR21_RS14725	COG2226	methyltransferase
GWR21_RS14735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWR21_RS14740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWR21_RS14745	COG0606	chelatase, subunit chli
GWR21_RS14750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWR21_RS14755	COG1132	(ABC) transporter
GWR21_RS14770	COG4771	TonB-dependent receptor
GWR21_RS14790	COG0183	Belongs to the thiolase family
GWR21_RS14835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWR21_RS15025	COG3631	Ketosteroid isomerase-related protein
GWR21_RS15050	COG1017	nitric oxide dioxygenase activity
GWR21_RS15050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWR21_RS15105	COG0488	(ABC) transporter
GWR21_RS15130	COG1764	response to oxidative stress
GWR21_RS15180	COG0667	Aldo Keto reductase
GWR21_RS15185	COG3118	belongs to the thioredoxin family
GWR21_RS15220	COG1846	Transcriptional regulator
GWR21_RS15230	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GWR21_RS15255	COG1629	transport
GWR21_RS15270	COG2304	oxidoreductase activity
GWR21_RS15275	COG3046	protein related to deoxyribodipyrimidine photolyase
GWR21_RS15280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWR21_RS15290	COG4771	TonB-dependent receptor
GWR21_RS15310	COG1629	transport
GWR21_RS15310	COG4206	TonB-dependent receptor
GWR21_RS15325	COG1528	Iron-storage protein
GWR21_RS15330	COG1917	Cupin 2, conserved barrel domain protein
GWR21_RS15340	COG2814	Major facilitator Superfamily
GWR21_RS15365	COG0667	Aldo Keto reductase
GWR21_RS15385	COG2207	Transcriptional regulator
GWR21_RS15395	COG1132	(ABC) transporter
GWR21_RS15400	COG1252	NADH dehydrogenase
GWR21_RS15405	COG1570	exodeoxyribonuclease VII activity
GWR21_RS15445	COG4251	negative regulation of phosphorylation
GWR21_RS15455	COG0784	Response regulator, receiver
GWR21_RS15465	COG0174	glutamine synthetase
GWR21_RS15475	COG4771	TonB-dependent receptor
GWR21_RS15490	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GWR21_RS15495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWR21_RS15525	COG1595	DNA-templated transcription, initiation
GWR21_RS15530	COG0167	dihydroorotate dehydrogenase activity
GWR21_RS15540	COG0702	epimerase
GWR21_RS15545	COG4206	TonB-dependent receptor
GWR21_RS15545	COG1629	transport
GWR21_RS15570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWR21_RS15585	COG0305	Participates in initiation and elongation during chromosome replication
GWR21_RS15605	COG1418	mRNA catabolic process
GWR21_RS15615	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GWR21_RS15625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GWR21_RS15645	COG4771	TonB-dependent receptor
GWR21_RS15685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWR21_RS15690	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWR21_RS15715	COG1629	transport
GWR21_RS15715	COG4206	TonB-dependent receptor
GWR21_RS15720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
GWR21_RS15725	COG1690	Belongs to the RtcB family
GWR21_RS15760	COG0673	inositol 2-dehydrogenase activity
GWR21_RS15780	COG0653	protein targeting
GWR21_RS15805	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWR21_RS15815	COG1473	amidohydrolase
GWR21_RS15825	COG1725	Transcriptional regulator
GWR21_RS15835	COG1131	(ABC) transporter
GWR21_RS15845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWR21_RS15850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWR21_RS15865	COG4152	abc transporter atp-binding protein
GWR21_RS15875	COG2972	Histidine kinase
GWR21_RS15880	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GWR21_RS15890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GWR21_RS15905	COG4771	TonB-dependent receptor
GWR21_RS15910	COG0702	epimerase
GWR21_RS15915	COG1785	Belongs to the alkaline phosphatase family
GWR21_RS15945	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWR21_RS16015	COG1506	peptidase
GWR21_RS16015	COG0823	Involved in the tonB-independent uptake of proteins
GWR21_RS16020	COG0702	epimerase
GWR21_RS16025	COG4771	TonB-dependent receptor
GWR21_RS16120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GWR21_RS16155	COG0702	epimerase
GWR21_RS16160	COG4771	TonB-dependent receptor
GWR21_RS16205	COG0513	Belongs to the DEAD box helicase family
GWR21_RS16245	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GWR21_RS16250	COG1397	ADP-ribosylglycohydrolase
GWR21_RS16270	COG4221	oxidoreductase activity
GWR21_RS16275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWR21_RS16285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWR21_RS16330	COG1917	Cupin 2, conserved barrel domain protein
GWR21_RS16330	COG2169	Transcriptional regulator
GWR21_RS16340	COG2197	response regulator
GWR21_RS16370	COG3250	beta-galactosidase activity
GWR21_RS16380	COG4251	negative regulation of phosphorylation
GWR21_RS16385	COG2814	Major facilitator Superfamily
GWR21_RS16395	COG1181	Belongs to the D-alanine--D-alanine ligase family
GWR21_RS16415	COG3604	Transcriptional regulator
GWR21_RS16445	COG4232	protein-disulfide reductase activity
GWR21_RS16450	COG4771	TonB-dependent receptor
GWR21_RS16480	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS16510	COG0702	epimerase
GWR21_RS16515	COG4771	TonB-dependent receptor
GWR21_RS16530	COG3217	Mosc domain protein beta barrel domain protein
GWR21_RS16530	COG0633	Ferredoxin
GWR21_RS16545	COG4221	oxidoreductase activity
GWR21_RS16565	COG4221	oxidoreductase activity
GWR21_RS16590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWR21_RS16600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWR21_RS16615	COG2153	protein acetylation
GWR21_RS16620	COG1119	ATPase activity
GWR21_RS16625	COG2373	Large extracellular alpha-helical protein
GWR21_RS16630	COG4953	penicillin-binding protein 1C
GWR21_RS16635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWR21_RS16645	COG3590	peptidase
GWR21_RS16695	COG0574	Belongs to the PEP-utilizing enzyme family
GWR21_RS16695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWR21_RS16725	COG0306	phosphate transporter
GWR21_RS16735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWR21_RS16740	COG3958	Transketolase
GWR21_RS16765	COG0772	Belongs to the SEDS family
GWR21_RS16770	COG0768	penicillin binding
GWR21_RS16780	COG1792	Involved in formation and maintenance of cell shape
GWR21_RS16795	COG3104	oligopeptide transport
GWR21_RS16820	COG0303	'Molybdopterin
GWR21_RS16825	COG0315	cyclic pyranopterin monophosphate synthase activity
GWR21_RS16830	COG0746	molybdenum cofactor guanylyltransferase activity
GWR21_RS16885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWR21_RS16890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWR21_RS16890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWR21_RS16940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWR21_RS16945	COG0346	lactoylglutathione lyase activity
GWR21_RS16950	COG1104	cysteine desulfurase activity
GWR21_RS16970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWR21_RS16975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GWR21_RS16985	COG0730	response to heat
GWR21_RS16995	COG1024	Enoyl-CoA hydratase
GWR21_RS17005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWR21_RS17010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWR21_RS17015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWR21_RS17020	COG0726	polysaccharide deacetylase
GWR21_RS17030	COG0084	hydrolase, TatD family'
GWR21_RS17035	COG0252	asparaginase activity
GWR21_RS17065	COG0784	Response regulator, receiver
GWR21_RS17065	COG2205	protein histidine kinase activity
GWR21_RS17065	COG5002	protein histidine kinase activity
GWR21_RS17110	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWR21_RS17130	COG4372	Transposase
GWR21_RS17145	COG4372	Transposase
GWR21_RS17180	COG2801	Transposase and inactivated derivatives
GWR21_RS17240	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GWR21_RS17255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWR21_RS17270	COG1764	response to oxidative stress
GWR21_RS17280	COG3275	phosphorelay sensor kinase activity
GWR21_RS17285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWR21_RS17310	COG0783	Belongs to the Dps family
GWR21_RS17325	COG1335	isochorismatase
GWR21_RS17330	COG1472	Belongs to the glycosyl hydrolase 3 family
GWR21_RS17335	COG4251	negative regulation of phosphorylation
GWR21_RS17340	COG2205	protein histidine kinase activity
GWR21_RS17340	COG3437	response regulator, receiver
GWR21_RS17340	COG3850	Histidine kinase
GWR21_RS17340	COG4999	Histidine kinase
GWR21_RS17345	COG0745	RESPONSE REGULATOR receiver
GWR21_RS17350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWR21_RS17370	COG4251	negative regulation of phosphorylation
GWR21_RS17400	COG0702	epimerase
GWR21_RS17405	COG4771	TonB-dependent receptor
GWR21_RS17440	COG3940	Belongs to the glycosyl hydrolase 43 family
GWR21_RS17455	COG1629	transport
GWR21_RS17470	COG2378	regulation of single-species biofilm formation
GWR21_RS17480	COG0571	ribonuclease III activity
GWR21_RS17485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWR21_RS17490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWR21_RS17500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWR21_RS17515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWR21_RS17520	COG4771	TonB-dependent receptor
GWR21_RS17540	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GWR21_RS17545	COG3279	Response regulator of the LytR AlgR family
GWR21_RS17550	COG3275	phosphorelay sensor kinase activity
GWR21_RS17555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GWR21_RS17560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWR21_RS17575	COG0783	Belongs to the Dps family
GWR21_RS17580	COG1741	Belongs to the pirin family
GWR21_RS17585	COG1764	response to oxidative stress
GWR21_RS17590	COG2353	YceI-like domain
GWR21_RS17610	COG1970	mechanosensitive ion channel activity
GWR21_RS17615	COG2326	polyphosphate kinase activity
GWR21_RS17620	COG0697	spore germination
GWR21_RS17625	COG0233	cytoplasmic translational termination
GWR21_RS17635	COG3959	Transketolase, thiamine diphosphate binding domain
GWR21_RS17645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GWR21_RS17650	COG1132	(ABC) transporter
GWR21_RS17665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWR21_RS17695	COG1629	transport
GWR21_RS17715	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWR21_RS17725	COG0423	glycine-tRNA ligase activity
GWR21_RS17735	COG1694	Mazg nucleotide pyrophosphohydrolase
GWR21_RS17740	COG1490	D-aminoacyl-tRNA deacylase activity
GWR21_RS17750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWR21_RS17760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWR21_RS17760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWR21_RS17775	COG4452	Inner membrane protein CreD
GWR21_RS17795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWR21_RS17800	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWR21_RS17815	COG1162	GTPase activity
GWR21_RS17820	COG2304	oxidoreductase activity
GWR21_RS17835	COG0714	Associated with various cellular activities
GWR21_RS17845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWR21_RS17850	COG0509	glycine decarboxylation via glycine cleavage system
GWR21_RS17865	COG2885	chlorophyll binding
GWR21_RS17870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GWR21_RS17875	COG0402	S-adenosylhomocysteine deaminase activity
GWR21_RS17880	COG0668	transmembrane transport
GWR21_RS17895	COG0739	heme binding
GWR21_RS17900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWR21_RS17905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWR21_RS17910	COG1012	belongs to the aldehyde dehydrogenase family
GWR21_RS17920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS17930	COG1629	transport
GWR21_RS17940	COG4771	TonB-dependent receptor
GWR21_RS17950	COG4771	TonB-dependent receptor
GWR21_RS17970	COG1381	Involved in DNA repair and RecF pathway recombination
GWR21_RS17975	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWR21_RS17985	COG1556	Lactate utilization protein
GWR21_RS17990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWR21_RS17995	COG0799	negative regulation of ribosome biogenesis
GWR21_RS18020	COG1597	lipid kinase activity
GWR21_RS18035	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWR21_RS18045	COG0322	excinuclease ABC activity
GWR21_RS18070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWR21_RS18075	COG1331	Highly conserved protein containing a thioredoxin domain
GWR21_RS18090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWR21_RS18100	COG1899	peptidyl-lysine modification to peptidyl-hypusine
GWR21_RS18110	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GWR21_RS18120	COG0626	cystathionine gamma-synthase activity
GWR21_RS18165	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GWR21_RS18180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWR21_RS18195	COG0438	transferase activity, transferring glycosyl groups
GWR21_RS18210	COG1703	isobutyryl-CoA mutase activity
GWR21_RS18230	COG2322	membrane
GWR21_RS18235	COG1999	signal sequence binding
GWR21_RS18245	COG1845	cytochrome c oxidase, subunit III
GWR21_RS18255	COG0109	protoheme IX farnesyltransferase activity
GWR21_RS18260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWR21_RS18265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWR21_RS18290	COG0437	4 iron, 4 sulfur cluster binding
GWR21_RS18300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWR21_RS18340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GWR21_RS18365	COG0556	nucleotide-excision repair
GWR21_RS18380	COG0534	Mate efflux family protein
GWR21_RS18390	COG2885	chlorophyll binding
GWR21_RS18420	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWR21_RS18440	COG2814	Major facilitator Superfamily
GWR21_RS18455	COG1309	transcriptional regulator
GWR21_RS18460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWR21_RS18475	COG0702	epimerase
GWR21_RS18480	COG1629	transport
GWR21_RS18480	COG4206	TonB-dependent receptor
GWR21_RS18540	COG3279	Response regulator of the LytR AlgR family
GWR21_RS18545	COG3437	response regulator, receiver
GWR21_RS18545	COG2205	protein histidine kinase activity
GWR21_RS18545	COG4999	Histidine kinase
GWR21_RS18545	COG3850	Histidine kinase
GWR21_RS18565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWR21_RS18565	COG0047	phosphoribosylformylglycinamidine synthase activity
GWR21_RS18590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWR21_RS18615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWR21_RS18620	COG1506	peptidase
GWR21_RS18620	COG0823	Involved in the tonB-independent uptake of proteins
GWR21_RS18625	COG1024	Enoyl-CoA hydratase
GWR21_RS18645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GWR21_RS18650	COG2045	Belongs to the ComB family
GWR21_RS18660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWR21_RS18665	COG2234	aminopeptidase activity
GWR21_RS18680	COG0577	efflux transmembrane transporter activity
GWR21_RS18725	COG0436	Aminotransferase
GWR21_RS18755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GWR21_RS18770	COG0352	thiamine-phosphate diphosphorylase activity
GWR21_RS18775	COG2022	thiamine diphosphate biosynthetic process
GWR21_RS18780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GWR21_RS18810	COG4771	TonB-dependent receptor
GWR21_RS18815	COG0702	epimerase
GWR21_RS18820	COG0024	Methionine aminopeptidase
GWR21_RS18825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWR21_RS18840	COG1733	regulation of RNA biosynthetic process
GWR21_RS18870	COG1011	Hydrolase
GWR21_RS18890	COG0779	Required for maturation of 30S ribosomal subunits
GWR21_RS18895	COG0195	Participates in both transcription termination and antitermination
GWR21_RS18900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWR21_RS18905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWR21_RS18920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GWR21_RS18925	COG1525	nuclease
GWR21_RS18940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWR21_RS18955	COG4589	Belongs to the CDS family
GWR21_RS18960	COG0688	phosphatidylethanolamine metabolic process
GWR21_RS18975	COG0300	oxidoreductase activity
GWR21_RS18995	COG3275	phosphorelay sensor kinase activity
GWR21_RS19000	COG0745	RESPONSE REGULATOR receiver
GWR21_RS19005	COG2205	protein histidine kinase activity
GWR21_RS19015	COG1561	YicC-like family, N-terminal region
GWR21_RS19020	COG1187	pseudouridine synthase activity
GWR21_RS19025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWR21_RS19070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWR21_RS19090	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWR21_RS19095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GWR21_RS19130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GWR21_RS19140	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GWR21_RS19145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWR21_RS19155	COG0612	Peptidase, M16
GWR21_RS19170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GWR21_RS19175	COG0010	Belongs to the arginase family
GWR21_RS19185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GWR21_RS19195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWR21_RS19195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWR21_RS19220	COG0009	L-threonylcarbamoyladenylate synthase
GWR21_RS19245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GWR21_RS19250	COG1649	PFAM Uncharacterised BCR, COG1649
GWR21_RS19255	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
GWR21_RS19260	COG0584	glycerophosphoryl diester phosphodiesterase
GWR21_RS19265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GWR21_RS19270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWR21_RS19275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWR21_RS19280	COG1349	DNA-binding transcription factor activity
GWR21_RS19290	COG0070	glutamate synthase
GWR21_RS19290	COG0069	glutamate synthase activity
GWR21_RS19290	COG0067	glutamate synthase
GWR21_RS19325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWR21_RS19330	COG0693	protein deglycase activity
GWR21_RS19340	COG0598	Magnesium transport protein CorA
GWR21_RS19350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWR21_RS19355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWR21_RS19365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GWR21_RS19370	COG0445	tRNA wobble uridine modification
GWR21_RS19375	COG2706	6-phosphogluconolactonase activity
GWR21_RS19385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWR21_RS19390	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GWR21_RS19390	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GWR21_RS19395	COG3552	Protein containing von Willebrand factor type A (VWA) domain
GWR21_RS19400	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GWR21_RS19405	COG0714	Associated with various cellular activities
GWR21_RS19430	COG0477	Major facilitator Superfamily
GWR21_RS19435	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWR21_RS19470	COG0514	ATP-dependent DNA helicase (RecQ)
GWR21_RS19485	COG0436	Aminotransferase
GWR21_RS19495	COG0659	secondary active sulfate transmembrane transporter activity
GWR21_RS19530	COG3396	Phenylacetate-CoA oxygenase
GWR21_RS19550	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWR21_RS19580	COG3757	hydrolase, family 25
GWR21_RS19605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWR21_RS19610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWR21_RS19615	COG1454	alcohol dehydrogenase
GWR21_RS19630	COG0022	dehydrogenase e1 component
GWR21_RS19635	COG1950	PFAM Membrane protein of
GWR21_RS19650	COG0673	inositol 2-dehydrogenase activity
GWR21_RS19670	COG0673	inositol 2-dehydrogenase activity
GWR21_RS19690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWR21_RS19710	COG1136	(ABC) transporter
GWR21_RS19735	COG0644	oxidoreductase
GWR21_RS19740	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GWR21_RS19770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWR21_RS19775	COG0563	adenylate kinase activity
GWR21_RS19780	COG1472	Belongs to the glycosyl hydrolase 3 family
GWR21_RS19790	COG1612	heme a metabolic process
GWR21_RS19800	COG2267	carboxylic ester hydrolase activity
GWR21_RS19805	COG1217	gtp-binding protein TYPA
GWR21_RS19830	COG3591	Belongs to the peptidase S1B family
GWR21_RS19840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWR21_RS19855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GWR21_RS19865	COG2234	aminopeptidase activity
GWR21_RS19870	COG0215	cysteine-tRNA ligase activity
GWR21_RS19895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GWR21_RS19920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GWR21_RS19925	COG1137	ATPase activity
GWR21_RS19935	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS19955	COG1774	PSP1 C-terminal conserved region
GWR21_RS19960	COG0470	DNA polymerase III
GWR21_RS19965	COG0386	Belongs to the glutathione peroxidase family
GWR21_RS19970	COG1040	competence protein
GWR21_RS19975	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWR21_RS19985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GWR21_RS19990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWR21_RS19995	COG0052	Belongs to the universal ribosomal protein uS2 family
GWR21_RS20000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GWR21_RS20005	COG0528	UMP kinase activity
GWR21_RS20025	COG0776	regulation of translation
GWR21_RS20035	COG0708	Exodeoxyribonuclease III
GWR21_RS20045	COG1410	methionine synthase
GWR21_RS20045	COG0646	methionine synthase
GWR21_RS20055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GWR21_RS20065	COG0210	DNA helicase
GWR21_RS20095	COG0583	DNA-binding transcription factor activity
GWR21_RS20105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GWR21_RS20125	COG0156	8-amino-7-oxononanoate synthase activity
GWR21_RS20130	COG1595	DNA-templated transcription, initiation
GWR21_RS20150	COG0612	Peptidase, M16
GWR21_RS20170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWR21_RS20190	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
GWR21_RS20195	COG1349	DNA-binding transcription factor activity
GWR21_RS20200	COG2223	nitrite transmembrane transporter activity
GWR21_RS20210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWR21_RS20220	COG0658	competence protein
GWR21_RS20220	COG2333	competence protein COMEC
GWR21_RS20225	COG0138	bifunctional purine biosynthesis protein purh
GWR21_RS20245	COG1139	Iron-sulfur cluster binding protein
GWR21_RS20265	COG0629	single-stranded DNA binding
GWR21_RS20285	COG1530	ribonuclease E activity
GWR21_RS20300	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWR21_RS20305	COG1214	PFAM Peptidase M22, glycoprotease
GWR21_RS20310	COG0640	Transcriptional regulator
GWR21_RS20315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWR21_RS20315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWR21_RS20320	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS20335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GWR21_RS20345	COG3852	Histidine kinase
GWR21_RS20360	COG0577	efflux transmembrane transporter activity
GWR21_RS20360	COG1136	(ABC) transporter
GWR21_RS20365	COG1136	(ABC) transporter
GWR21_RS20370	COG0577	efflux transmembrane transporter activity
GWR21_RS20370	COG1136	(ABC) transporter
GWR21_RS20380	COG0577	efflux transmembrane transporter activity
GWR21_RS20385	COG1136	(ABC) transporter
GWR21_RS20415	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GWR21_RS20420	COG1629	transport
GWR21_RS20450	COG4206	TonB-dependent receptor
GWR21_RS20450	COG1629	transport
GWR21_RS20490	COG1357	PFAM Pentapeptide repeats (8 copies)
GWR21_RS20490	COG0515	serine threonine protein kinase
GWR21_RS20510	COG0745	RESPONSE REGULATOR receiver
GWR21_RS20525	COG3852	Histidine kinase
GWR21_RS20530	COG0784	Response regulator, receiver
GWR21_RS20535	COG4251	negative regulation of phosphorylation
GWR21_RS20545	COG3685	Protein conserved in bacteria
GWR21_RS20550	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS20565	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GWR21_RS20600	COG0017	Asparaginyl-tRNA synthetase
GWR21_RS20605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GWR21_RS20615	COG3275	phosphorelay sensor kinase activity
GWR21_RS20620	COG2154	pterin-4-alpha-carbinolamine dehydratase
GWR21_RS20640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWR21_RS20645	COG1522	sequence-specific DNA binding
GWR21_RS20660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWR21_RS20665	COG0194	GDP metabolic process
GWR21_RS20670	COG4535	Mg2 and Co2 transporter CorC
GWR21_RS20675	COG0805	protein transport
GWR21_RS20700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWR21_RS20705	COG0346	lactoylglutathione lyase activity
GWR21_RS20710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GWR21_RS20720	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWR21_RS20725	COG0483	inositol monophosphate 1-phosphatase activity
GWR21_RS20740	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWR21_RS20770	COG0860	N-Acetylmuramoyl-L-alanine amidase
GWR21_RS20775	COG1960	acyl-CoA dehydrogenase activity
GWR21_RS20785	COG1215	transferase activity, transferring glycosyl groups
GWR21_RS20790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWR21_RS20810	COG1610	YqeY-like protein
GWR21_RS20845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWR21_RS20855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWR21_RS20875	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GWR21_RS20880	COG0594	ribonuclease P activity
GWR21_RS20890	COG0793	Belongs to the peptidase S41A family
GWR21_RS20895	COG0673	inositol 2-dehydrogenase activity
GWR21_RS20905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWR21_RS20920	COG0330	HflC and HflK could
GWR21_RS20925	COG0590	tRNA wobble adenosine to inosine editing
GWR21_RS20930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWR21_RS20940	COG1703	isobutyryl-CoA mutase activity
GWR21_RS20940	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWR21_RS20940	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWR21_RS20950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWR21_RS20975	COG1595	DNA-templated transcription, initiation
GWR21_RS20980	COG0562	UDP-galactopyranose mutase
GWR21_RS21000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWR21_RS21005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GWR21_RS21015	COG2089	acid synthase
GWR21_RS21020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GWR21_RS21025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWR21_RS21030	COG1083	cytidylyl-transferase
GWR21_RS21050	COG0438	transferase activity, transferring glycosyl groups
GWR21_RS21060	COG0438	transferase activity, transferring glycosyl groups
GWR21_RS21065	COG0438	transferase activity, transferring glycosyl groups
GWR21_RS21075	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GWR21_RS21080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWR21_RS21090	COG0488	(ABC) transporter
GWR21_RS21110	COG4771	TonB-dependent receptor
GWR21_RS21180	COG1022	Amp-dependent synthetase and ligase
GWR21_RS21190	COG2223	nitrite transmembrane transporter activity
GWR21_RS21195	COG2186	Transcriptional regulator
GWR21_RS21205	COG2095	MarC family integral membrane protein
GWR21_RS21220	COG1215	transferase activity, transferring glycosyl groups
GWR21_RS21225	COG4942	peptidase
GWR21_RS21240	COG1979	alcohol dehydrogenase
GWR21_RS21260	COG1733	regulation of RNA biosynthetic process
GWR21_RS21275	COG1012	belongs to the aldehyde dehydrogenase family
GWR21_RS21290	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GWR21_RS21305	COG1309	transcriptional regulator
GWR21_RS21315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWR21_RS21320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWR21_RS21330	COG3844	kynureninase activity
GWR21_RS21350	COG1595	DNA-templated transcription, initiation
GWR21_RS21365	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWR21_RS21365	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWR21_RS21375	COG0673	inositol 2-dehydrogenase activity
GWR21_RS21380	COG2211	Major facilitator Superfamily
GWR21_RS21390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWR21_RS21405	COG0148	phosphopyruvate hydratase activity
GWR21_RS21410	COG1131	(ABC) transporter
GWR21_RS21425	COG4245	von Willebrand factor, type A
GWR21_RS21440	COG2310	stress, protein
GWR21_RS21470	COG0861	Integral membrane protein TerC family
GWR21_RS21480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWR21_RS21485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWR21_RS21500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GWR21_RS21505	COG0756	dUTP diphosphatase activity
GWR21_RS21525	COG0438	transferase activity, transferring glycosyl groups
GWR21_RS21555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWR21_RS21560	COG2304	oxidoreductase activity
GWR21_RS21565	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWR21_RS21570	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GWR21_RS21585	COG0450	alkyl hydroperoxide reductase
GWR21_RS21590	COG0564	pseudouridine synthase activity
GWR21_RS21595	COG1187	pseudouridine synthase activity
GWR21_RS21600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GWR21_RS21605	COG0183	Belongs to the thiolase family
GWR21_RS21610	COG1595	DNA-templated transcription, initiation
GWR21_RS21615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWR21_RS21625	COG0280	phosphate acetyltransferase
GWR21_RS21625	COG0281	malic enzyme
GWR21_RS21635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWR21_RS21640	COG1127	ABC transporter
GWR21_RS21645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWR21_RS21650	COG2373	Large extracellular alpha-helical protein
GWR21_RS21660	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GWR21_RS21680	COG1696	Membrane protein involved in D-alanine export
GWR21_RS21690	COG5002	protein histidine kinase activity
GWR21_RS21695	COG0745	RESPONSE REGULATOR receiver
GWR21_RS21710	COG1132	(ABC) transporter
GWR21_RS21720	COG0356	it plays a direct role in the translocation of protons across the membrane
GWR21_RS21725	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWR21_RS21730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GWR21_RS21735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GWR21_RS21740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GWR21_RS21760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GWR21_RS21765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWR21_RS21770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWR21_RS21775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWR21_RS21790	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GWR21_RS21810	COG0745	RESPONSE REGULATOR receiver
GWR21_RS21815	COG2205	protein histidine kinase activity
GWR21_RS21825	COG3781	membrane
GWR21_RS21830	COG2255	four-way junction helicase activity
GWR21_RS21845	COG0495	leucyl-tRNA aminoacylation
GWR21_RS21850	COG2177	Part of the ABC transporter FtsEX involved in
GWR21_RS21860	COG1968	undecaprenyl-diphosphatase activity
GWR21_RS21870	COG0802	atpase or kinase
GWR21_RS21875	COG2217	Heavy metal translocating P-type atpase
GWR21_RS21880	COG0514	ATP-dependent DNA helicase (RecQ)
GWR21_RS21885	COG0673	inositol 2-dehydrogenase activity
GWR21_RS21900	COG0433	COG0433 Predicted ATPase
GWR21_RS21905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GWR21_RS21910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWR21_RS21915	COG2270	Major facilitator Superfamily
GWR21_RS21920	COG1131	(ABC) transporter
GWR21_RS21925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWR21_RS21930	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GWR21_RS21930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWR21_RS21935	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWR21_RS21940	COG1078	dGTPase activity
GWR21_RS21945	COG2204	response regulator
GWR21_RS21970	COG1960	acyl-CoA dehydrogenase activity
GWR21_RS21990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GWR21_RS21995	COG0740	serine-type endopeptidase activity
GWR21_RS22000	COG0544	peptidyl-prolyl cis-trans isomerase activity
GWR21_RS22015	COG2814	Major facilitator Superfamily
GWR21_RS22020	COG1473	amidohydrolase
GWR21_RS22050	COG0531	amino acid
GWR21_RS22070	COG2201	protein-glutamate methylesterase activity
GWR21_RS22075	COG2204	response regulator
GWR21_RS22080	COG4191	Histidine kinase
GWR21_RS22080	COG2205	protein histidine kinase activity
GWR21_RS22080	COG0745	RESPONSE REGULATOR receiver
GWR21_RS22105	COG0671	phosphoesterase, PA-phosphatase related
GWR21_RS22125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GWR21_RS22130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWR21_RS22135	COG0228	four-way junction DNA binding
GWR21_RS22140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWR21_RS22145	COG0336	Belongs to the RNA methyltransferase TrmD family
GWR21_RS22150	COG0335	large ribosomal subunit rRNA binding
GWR21_RS22155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWR21_RS22160	COG0154	amidase activity
GWR21_RS22170	COG0475	glutathione-regulated potassium exporter activity
GWR21_RS22195	COG0492	ferredoxin-NADP+ reductase activity
GWR21_RS22215	COG3604	Transcriptional regulator
GWR21_RS22220	COG2204	response regulator
GWR21_RS22230	COG1764	response to oxidative stress
GWR21_RS22245	COG2267	carboxylic ester hydrolase activity
GWR21_RS22255	COG1733	regulation of RNA biosynthetic process
GWR21_RS22290	COG4251	negative regulation of phosphorylation
GWR21_RS22360	COG0667	Aldo Keto reductase
GWR21_RS22400	COG0126	phosphoglycerate kinase activity
GWR21_RS22405	COG1301	dicarboxylic acid transport
GWR21_RS22410	COG3275	phosphorelay sensor kinase activity
GWR21_RS22450	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GWR21_RS22480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GWR21_RS22495	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWR21_RS22520	COG0511	ligase activity, forming carbon-carbon bonds
GWR21_RS22530	COG0101	tRNA pseudouridine synthase activity
GWR21_RS22670	COG0811	peptide transport
GWR21_RS22690	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GWR21_RS22700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWR21_RS22750	COG1401	restriction endodeoxyribonuclease activity
GWR21_RS22760	COG0667	Aldo Keto reductase
GWR21_RS22770	COG3537	Alpha-1,2-mannosidase
GWR21_RS22785	COG4771	TonB-dependent receptor
GWR21_RS22795	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS22805	COG1609	Transcriptional regulator
GWR21_RS22815	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWR21_RS22820	COG1085	galactose-1-phosphate uridylyltransferase
GWR21_RS22840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GWR21_RS22845	COG0831	urea catabolic process
GWR21_RS22850	COG0832	Belongs to the urease beta subunit family
GWR21_RS22855	COG0804	urea catabolic process
GWR21_RS22860	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GWR21_RS22870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GWR21_RS22875	COG0829	nickel cation binding
GWR21_RS22885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GWR21_RS22890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GWR21_RS22895	COG0363	glucosamine-6-phosphate deaminase activity
GWR21_RS22910	COG0069	glutamate synthase activity
GWR21_RS22915	COG0668	transmembrane transport
GWR21_RS22925	COG0589	response to stress
GWR21_RS22930	COG0392	lysyltransferase activity
GWR21_RS22930	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GWR21_RS22950	COG2197	response regulator
GWR21_RS22955	COG1629	transport
GWR21_RS22960	COG0702	epimerase
GWR21_RS22990	COG1312	Catalyzes the dehydration of D-mannonate
GWR21_RS22995	COG2379	hydroxypyruvate reductase
GWR21_RS23005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWR21_RS23010	COG1228	amidohydrolase
GWR21_RS23020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWR21_RS23045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWR21_RS23060	COG1519	Transferase
GWR21_RS23080	COG0439	Biotin carboxylase
GWR21_RS23100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWR21_RS23110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWR21_RS23115	COG4172	Belongs to the ABC transporter superfamily
GWR21_RS23120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GWR21_RS23125	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GWR21_RS23130	COG0673	inositol 2-dehydrogenase activity
GWR21_RS23135	COG2003	Belongs to the UPF0758 family
GWR21_RS23140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWR21_RS23145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GWR21_RS23150	COG0193	aminoacyl-tRNA hydrolase activity
GWR21_RS23155	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWR21_RS23160	COG1846	Transcriptional regulator
GWR21_RS23165	COG0022	dehydrogenase e1 component
GWR21_RS23175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GWR21_RS23240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWR21_RS23245	COG3422	double-strand break repair
GWR21_RS23270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWR21_RS23275	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GWR21_RS23295	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GWR21_RS23300	COG4682	membrane
GWR21_RS23310	COG1446	asparaginase
GWR21_RS23320	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GWR21_RS23370	COG1629	transport
GWR21_RS23375	COG0702	epimerase
GWR21_RS23415	COG1477	protein flavinylation
GWR21_RS23420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS23425	COG3264	Mechanosensitive ion channel
GWR21_RS23425	COG1196	nuclear chromosome segregation
GWR21_RS23440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWR21_RS23450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWR21_RS23460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GWR21_RS23465	COG0049	tRNA binding
GWR21_RS23490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWR21_RS23500	COG0051	transcription antitermination factor activity, RNA binding
GWR21_RS23505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWR21_RS23510	COG0088	Forms part of the polypeptide exit tunnel
GWR21_RS23515	COG0089	rRNA binding
GWR21_RS23520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWR21_RS23525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWR21_RS23530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GWR21_RS23535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWR21_RS23540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GWR21_RS23545	COG0255	Belongs to the universal ribosomal protein uL29 family
GWR21_RS23550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWR21_RS23555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWR21_RS23560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GWR21_RS23565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWR21_RS23570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GWR21_RS23575	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWR21_RS23580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GWR21_RS23585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GWR21_RS23590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWR21_RS23595	COG1841	ribosomal large subunit assembly
GWR21_RS23610	COG0024	Methionine aminopeptidase
GWR21_RS23615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GWR21_RS23620	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GWR21_RS23625	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWR21_RS23630	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWR21_RS23635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GWR21_RS23640	COG0202	RNA polymerase activity
GWR21_RS23645	COG0203	ribosomal protein L17
GWR21_RS23655	COG0505	Belongs to the CarA family
GWR21_RS23660	COG0436	Aminotransferase
GWR21_RS23685	COG0531	amino acid
GWR21_RS23690	COG1301	dicarboxylic acid transport
GWR21_RS23695	COG0586	Pfam SNARE associated Golgi protein
GWR21_RS23700	COG2814	Major facilitator Superfamily
GWR21_RS23710	COG0039	L-malate dehydrogenase activity
GWR21_RS23720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GWR21_RS23725	COG0511	ligase activity, forming carbon-carbon bonds
GWR21_RS23730	COG0439	Biotin carboxylase
GWR21_RS23745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWR21_RS23750	COG0156	8-amino-7-oxononanoate synthase activity
GWR21_RS23780	COG1809	phosphosulfolactate synthase activity
GWR21_RS23785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWR21_RS23790	COG2226	methyltransferase
GWR21_RS23795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWR21_RS23805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWR21_RS23810	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWR21_RS23820	COG1252	NADH dehydrogenase
GWR21_RS23825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWR21_RS23865	COG0714	Associated with various cellular activities
GWR21_RS23885	COG1733	regulation of RNA biosynthetic process
GWR21_RS23895	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWR21_RS23915	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GWR21_RS23920	COG4974	Belongs to the 'phage' integrase family
GWR21_RS23985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWR21_RS23990	COG0081	regulation of translation
GWR21_RS23995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GWR21_RS24000	COG0222	ribosome binding
GWR21_RS24005	COG0085	RNA polymerase activity
GWR21_RS24010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWR21_RS24025	COG0531	amino acid
GWR21_RS24100	COG0861	Integral membrane protein TerC family
GWR21_RS24105	COG0702	epimerase
GWR21_RS24135	COG2197	response regulator
GWR21_RS24145	COG4771	TonB-dependent receptor
GWR21_RS24180	COG2885	chlorophyll binding
GWR21_RS24195	COG3537	Alpha-1,2-mannosidase
GWR21_RS24200	COG0640	Transcriptional regulator
GWR21_RS24205	COG0019	diaminopimelate decarboxylase activity
GWR21_RS24235	COG3961	Belongs to the TPP enzyme family
GWR21_RS24280	COG2267	carboxylic ester hydrolase activity
GWR21_RS24360	COG4771	TonB-dependent receptor
GWR21_RS24365	COG0702	epimerase
GWR21_RS24405	COG0784	Response regulator, receiver
GWR21_RS24430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWR21_RS24435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GWR21_RS24445	COG4771	TonB-dependent receptor
GWR21_RS24450	COG0702	epimerase
GWR21_RS24480	COG3250	beta-galactosidase activity
GWR21_RS24490	COG3940	Belongs to the glycosyl hydrolase 43 family
GWR21_RS24495	COG3250	beta-galactosidase activity
GWR21_RS24500	COG3408	Glycogen debranching enzyme
GWR21_RS24505	COG4677	pectinesterase activity
GWR21_RS24515	COG1472	Belongs to the glycosyl hydrolase 3 family
GWR21_RS24520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GWR21_RS24525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWR21_RS24530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWR21_RS24535	COG0131	Imidazoleglycerol-phosphate dehydratase
GWR21_RS24540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWR21_RS24550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWR21_RS24555	COG0134	indole-3-glycerol-phosphate synthase activity
GWR21_RS24560	COG0135	phosphoribosylanthranilate isomerase activity
GWR21_RS24565	COG0133	tryptophan synthase activity
GWR21_RS24570	COG0159	tryptophan synthase activity
GWR21_RS24580	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWR21_RS24585	COG0107	imidazoleglycerol-phosphate synthase activity
GWR21_RS24590	COG0140	phosphoribosyl-ATP diphosphatase activity
GWR21_RS24590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWR21_RS24595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS24600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS24610	COG4771	TonB-dependent receptor
GWR21_RS24625	COG2723	6-phospho-beta-galactosidase activity
GWR21_RS24650	COG3275	phosphorelay sensor kinase activity
GWR21_RS24655	COG3279	Response regulator of the LytR AlgR family
GWR21_RS24660	COG1104	cysteine desulfurase activity
GWR21_RS24675	COG0500	methyltransferase
GWR21_RS24680	COG0671	phosphoesterase, PA-phosphatase related
GWR21_RS24690	COG1253	flavin adenine dinucleotide binding
GWR21_RS24695	COG2986	histidine ammonia-lyase
GWR21_RS24700	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS24705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWR21_RS24710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWR21_RS24740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWR21_RS24755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWR21_RS24760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWR21_RS24770	COG0726	polysaccharide deacetylase
GWR21_RS24790	COG0463	Glycosyl transferase, family 2
GWR21_RS24810	COG0736	holo-[acyl-carrier-protein] synthase activity
GWR21_RS24855	COG4771	TonB-dependent receptor
GWR21_RS24865	COG1629	transport
GWR21_RS24890	COG4206	TonB-dependent receptor
GWR21_RS24890	COG1629	transport
GWR21_RS24910	COG4771	TonB-dependent receptor
GWR21_RS24925	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWR21_RS24930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWR21_RS24945	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWR21_RS24950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GWR21_RS24955	COG0242	peptide deformylase activity
GWR21_RS24960	COG1595	DNA-templated transcription, initiation
GWR21_RS24970	COG1595	DNA-templated transcription, initiation
GWR21_RS24990	COG0564	pseudouridine synthase activity
GWR21_RS24995	COG0321	lipoyl(octanoyl) transferase activity
GWR21_RS25000	COG0300	oxidoreductase activity
GWR21_RS25015	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GWR21_RS25040	COG0028	Belongs to the TPP enzyme family
GWR21_RS25050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWR21_RS25055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWR21_RS25060	COG0604	alcohol dehydrogenase
GWR21_RS25075	COG1070	Carbohydrate kinase
GWR21_RS25080	COG2115	Belongs to the xylose isomerase family
GWR21_RS25085	COG2017	converts alpha-aldose to the beta-anomer
GWR21_RS25090	COG3237	CsbD-like
GWR21_RS25105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWR21_RS25135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GWR21_RS25140	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GWR21_RS25145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWR21_RS25150	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWR21_RS25175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWR21_RS25175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWR21_RS25190	COG0793	Belongs to the peptidase S41A family
GWR21_RS25195	COG2912	Transglutaminase-like superfamily
GWR21_RS25220	COG0424	maF-like protein
GWR21_RS25280	COG0460	homoserine dehydrogenase
GWR21_RS25285	COG0626	cystathionine gamma-synthase activity
GWR21_RS25300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWR21_RS25330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWR21_RS25340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWR21_RS25340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWR21_RS25345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWR21_RS25350	COG3842	ATPase activity
GWR21_RS25365	COG0673	inositol 2-dehydrogenase activity
GWR21_RS25380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWR21_RS25385	COG4106	trans-aconitate 2-methyltransferase activity
GWR21_RS25390	COG0066	3-isopropylmalate dehydratase activity
GWR21_RS25395	COG0473	3-isopropylmalate dehydrogenase activity
GWR21_RS25400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWR21_RS25410	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS25420	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWR21_RS25430	COG3618	amidohydrolase
GWR21_RS25435	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS25455	COG1858	cytochrome C peroxidase
GWR21_RS25460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWR21_RS25465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWR21_RS25475	COG2239	Acts as a magnesium transporter
GWR21_RS25480	COG3781	membrane
GWR21_RS25495	COG2986	histidine ammonia-lyase
GWR21_RS25500	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GWR21_RS25505	COG1228	amidohydrolase
GWR21_RS25530	COG0788	formyltetrahydrofolate deformylase activity
GWR21_RS25570	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GWR21_RS25575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWR21_RS25580	COG2895	sulfate adenylyltransferase (ATP) activity
GWR21_RS25585	COG0175	sulfate reduction
GWR21_RS25590	COG0175	sulfate reduction
GWR21_RS25595	COG1959	2 iron, 2 sulfur cluster binding
GWR21_RS25600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GWR21_RS25610	COG1475	DNA binding
GWR21_RS25615	COG1192	Involved in chromosome partitioning
GWR21_RS25620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWR21_RS25625	COG1408	metallophosphoesterase
GWR21_RS25640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWR21_RS25650	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GWR21_RS25655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWR21_RS25670	COG0456	acetyltransferase
GWR21_RS25680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWR21_RS25680	COG1796	DNA polymerase
GWR21_RS25690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GWR21_RS25695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GWR21_RS25705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GWR21_RS25785	COG1049	propionate catabolic process, 2-methylcitrate cycle
GWR21_RS25825	COG0697	spore germination
GWR21_RS25830	COG4977	sequence-specific DNA binding
GWR21_RS25840	COG4585	Histidine kinase
GWR21_RS25845	COG2197	response regulator
GWR21_RS25850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS25855	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS25865	COG3604	Transcriptional regulator
GWR21_RS25880	COG3279	Response regulator of the LytR AlgR family
GWR21_RS25890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWR21_RS25900	COG1538	Outer membrane efflux protein
GWR21_RS25925	COG4771	TonB-dependent receptor
GWR21_RS25930	COG3876	Protein conserved in bacteria
GWR21_RS25965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWR21_RS25975	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GWR21_RS26035	COG1917	Cupin 2, conserved barrel domain protein
GWR21_RS26035	COG4977	sequence-specific DNA binding
GWR21_RS26045	COG1917	Cupin 2, conserved barrel domain protein
GWR21_RS26045	COG2169	Transcriptional regulator
GWR21_RS26050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GWR21_RS26060	COG0783	Belongs to the Dps family
GWR21_RS26065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWR21_RS26070	COG2814	Major facilitator Superfamily
GWR21_RS26085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWR21_RS26100	COG2080	2 iron, 2 sulfur cluster binding
GWR21_RS26105	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GWR21_RS26110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWR21_RS26125	COG3842	ATPase activity
GWR21_RS26130	COG0210	DNA helicase
GWR21_RS26135	COG0784	Response regulator, receiver
GWR21_RS26140	COG4251	negative regulation of phosphorylation
GWR21_RS26145	COG2080	2 iron, 2 sulfur cluster binding
GWR21_RS26150	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GWR21_RS26155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWR21_RS26160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWR21_RS26165	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GWR21_RS26170	COG1074	ATP-dependent DNA helicase activity
GWR21_RS26180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GWR21_RS26190	COG0366	Alpha amylase catalytic
GWR21_RS26205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWR21_RS26210	COG0745	RESPONSE REGULATOR receiver
GWR21_RS26225	COG2885	chlorophyll binding
GWR21_RS26265	COG4206	TonB-dependent receptor
GWR21_RS26265	COG1629	transport
GWR21_RS26325	COG1830	Aldolase
GWR21_RS26350	COG1064	alcohol dehydrogenase
GWR21_RS26360	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS26375	COG2267	carboxylic ester hydrolase activity
GWR21_RS26395	COG2890	protein-(glutamine-N5) methyltransferase activity
GWR21_RS26400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWR21_RS26400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWR21_RS26410	COG1739	Uncharacterized protein family UPF0029
GWR21_RS26415	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWR21_RS26425	COG0489	protein tyrosine kinase activity
GWR21_RS26430	COG0673	inositol 2-dehydrogenase activity
GWR21_RS26440	COG0284	orotidine-5'-phosphate decarboxylase activity
GWR21_RS26490	COG3842	ATPase activity
GWR21_RS26510	COG3290	protein histidine kinase activity
GWR21_RS26515	COG0438	transferase activity, transferring glycosyl groups
GWR21_RS26515	COG1216	Glycosyl transferase, family 2
GWR21_RS26545	COG4771	TonB-dependent receptor
GWR21_RS26565	COG1215	transferase activity, transferring glycosyl groups
GWR21_RS26575	COG0745	RESPONSE REGULATOR receiver
GWR21_RS26585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GWR21_RS26595	COG4251	negative regulation of phosphorylation
GWR21_RS26615	COG4206	TonB-dependent receptor
GWR21_RS26615	COG1629	transport
GWR21_RS26625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS26645	COG0673	inositol 2-dehydrogenase activity
GWR21_RS26660	COG3250	beta-galactosidase activity
GWR21_RS26710	COG0489	protein tyrosine kinase activity
GWR21_RS26710	COG3206	protein involved in exopolysaccharide biosynthesis
GWR21_RS26735	COG1690	Belongs to the RtcB family
GWR21_RS26740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWR21_RS26755	COG2132	Multicopper oxidase
GWR21_RS26775	COG0542	response to heat
GWR21_RS26870	COG1072	(Pantothenic acid kinase))
GWR21_RS26875	COG1012	belongs to the aldehyde dehydrogenase family
GWR21_RS26895	COG0205	6-phosphofructokinase activity
GWR21_RS26900	COG1505	serine-type exopeptidase activity
GWR21_RS26905	COG1091	dTDP-4-dehydrorhamnose reductase activity
GWR21_RS26925	COG2259	Doxx family
GWR21_RS26935	COG1546	Belongs to the CinA family
GWR21_RS26935	COG1058	Belongs to the CinA family
GWR21_RS26940	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWR21_RS26945	COG0724	RNA recognition motif
GWR21_RS26990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWR21_RS27000	COG0163	prenyltransferase activity
GWR21_RS27005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GWR21_RS27010	COG1363	Peptidase, m42
GWR21_RS27020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWR21_RS27055	COG5002	protein histidine kinase activity
GWR21_RS27060	COG2197	response regulator
GWR21_RS27070	COG0489	protein tyrosine kinase activity
GWR21_RS27080	COG0662	Cupin 2, conserved barrel domain protein
GWR21_RS27080	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GWR21_RS27085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWR21_RS27095	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GWR21_RS27130	COG0438	transferase activity, transferring glycosyl groups
GWR21_RS27140	COG0110	maltose O-acetyltransferase activity
GWR21_RS27145	COG0297	glycogen (starch) synthase activity
GWR21_RS27150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWR21_RS27160	COG0579	oxidoreductase
GWR21_RS27165	COG1773	rubredoxin
GWR21_RS27170	COG0243	molybdopterin cofactor binding
GWR21_RS27175	COG2223	nitrite transmembrane transporter activity
GWR21_RS27190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWR21_RS27195	COG1648	precorrin-2 dehydrogenase activity
GWR21_RS27195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWR21_RS27215	COG0753	catalase activity
GWR21_RS27220	COG3685	Protein conserved in bacteria
GWR21_RS27270	COG4619	ABC transporter
GWR21_RS27290	COG4773	Receptor
GWR21_RS27325	COG0577	efflux transmembrane transporter activity
GWR21_RS27370	COG0456	acetyltransferase
GWR21_RS27375	COG0702	epimerase
GWR21_RS27400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWR21_RS27430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWR21_RS27440	COG0671	phosphoesterase, PA-phosphatase related
GWR21_RS27450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GWR21_RS27475	COG2188	Transcriptional regulator
GWR21_RS27490	COG2814	Major facilitator Superfamily
GWR21_RS27500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GWR21_RS27505	COG2169	Transcriptional regulator
GWR21_RS27510	COG0028	Belongs to the TPP enzyme family
GWR21_RS27520	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS27540	COG0531	amino acid
GWR21_RS27555	COG4771	TonB-dependent receptor
GWR21_RS27560	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GWR21_RS27570	COG0753	catalase activity
GWR21_RS27575	COG0583	DNA-binding transcription factor activity
GWR21_RS27615	COG0596	Alpha beta hydrolase
GWR21_RS27645	COG1063	alcohol dehydrogenase
GWR21_RS27665	COG4628	conserved protein (DUF2132)
GWR21_RS27675	COG0577	efflux transmembrane transporter activity
GWR21_RS27695	COG2382	esterase
GWR21_RS27695	COG3693	PFAM glycoside hydrolase, family 10
GWR21_RS27695	COG3507	Belongs to the glycosyl hydrolase 43 family
GWR21_RS27710	COG4771	TonB-dependent receptor
GWR21_RS27905	COG3344	reverse transcriptase
GWR21_RS27925	COG0366	Alpha amylase catalytic
GWR21_RS27960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWR21_RS27970	COG5002	protein histidine kinase activity
GWR21_RS27975	COG0745	RESPONSE REGULATOR receiver
GWR21_RS28010	COG3239	Fatty acid desaturase
GWR21_RS28025	COG0584	glycerophosphoryl diester phosphodiesterase
GWR21_RS28035	COG0513	Belongs to the DEAD box helicase family
GWR21_RS28050	COG1755	Isoprenylcysteine carboxyl methyltransferase
GWR21_RS28055	COG1271	oxidase subunit
GWR21_RS28080	COG1629	transport
GWR21_RS28080	COG4206	TonB-dependent receptor
GWR21_RS28115	COG0667	Aldo Keto reductase
GWR21_RS28135	COG2814	Major facilitator Superfamily
GWR21_RS28150	COG4771	TonB-dependent receptor
GWR21_RS28195	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWR21_RS28220	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS28235	COG3279	Response regulator of the LytR AlgR family
GWR21_RS28260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWR21_RS28300	COG1309	transcriptional regulator
GWR21_RS28310	COG2814	Major facilitator Superfamily
GWR21_RS28370	COG1733	regulation of RNA biosynthetic process
GWR21_RS28375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWR21_RS28380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWR21_RS28385	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GWR21_RS28390	COG2080	2 iron, 2 sulfur cluster binding
GWR21_RS28405	COG2192	nodulation
GWR21_RS28415	COG0367	asparagine synthase
GWR21_RS28445	COG1509	lysine 2,3-aminomutase activity
GWR21_RS28455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWR21_RS28470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GWR21_RS28500	COG3250	beta-galactosidase activity
GWR21_RS28560	COG1136	(ABC) transporter
GWR21_RS28560	COG0577	efflux transmembrane transporter activity
GWR21_RS28570	COG2207	Transcriptional regulator
GWR21_RS28570	COG4753	response regulator
GWR21_RS28575	COG1733	regulation of RNA biosynthetic process
GWR21_RS28590	COG0531	amino acid
GWR21_RS28620	COG4977	sequence-specific DNA binding
GWR21_RS28625	COG0531	amino acid
GWR21_RS28635	COG4302	ethanolamine ammonia-lyase activity
GWR21_RS28650	COG1629	transport
GWR21_RS28650	COG4206	TonB-dependent receptor
GWR21_RS28705	COG1193	negative regulation of DNA recombination
GWR21_RS28710	COG1846	Transcriptional regulator
GWR21_RS28730	COG1538	Outer membrane efflux protein
GWR21_RS28760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWR21_RS28810	COG3387	PFAM Glycoside hydrolase 15-related
GWR21_RS28815	COG0823	Involved in the tonB-independent uptake of proteins
GWR21_RS28865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWR21_RS28875	COG1011	Hydrolase
GWR21_RS28905	COG4771	TonB-dependent receptor
GWR21_RS28915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWR21_RS28925	COG0546	phosphoglycolate phosphatase activity
GWR21_RS28960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWR21_RS29010	COG0793	Belongs to the peptidase S41A family
GWR21_RS29030	COG3590	peptidase
GWR21_RS29070	COG1733	regulation of RNA biosynthetic process
GWR21_RS29135	COG0588	phosphoglycerate mutase activity
GWR21_RS29140	COG2197	response regulator
GWR21_RS29145	COG4585	Histidine kinase
GWR21_RS29165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWR21_RS29185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWR21_RS29190	COG1131	(ABC) transporter
GWR21_RS29195	COG1131	(ABC) transporter
GWR21_RS29200	COG0842	Transport permease protein
GWR21_RS29205	COG0842	Transport permease protein
GWR21_RS29210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWR21_RS29215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWR21_RS29215	COG2169	Transcriptional regulator
GWR21_RS29220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GWR21_RS29235	COG0697	spore germination
GWR21_RS29240	COG0456	acetyltransferase
GWR21_RS29250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWR21_RS29275	COG1484	DNA-dependent DNA replication
GWR21_RS29305	COG3621	Patatin-like phospholipase
GWR21_RS29345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS29465	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWR21_RS29470	COG1733	regulation of RNA biosynthetic process
GWR21_RS29490	COG3781	membrane
GWR21_RS29495	COG2217	Heavy metal translocating P-type atpase
GWR21_RS29525	COG4585	Histidine kinase
GWR21_RS29530	COG2197	response regulator
GWR21_RS29565	COG1881	PFAM PEBP family protein
GWR21_RS29575	COG0697	spore germination
GWR21_RS29600	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWR21_RS29610	COG0156	8-amino-7-oxononanoate synthase activity
GWR21_RS29630	COG0739	heme binding
GWR21_RS29635	COG0668	transmembrane transport
GWR21_RS29645	COG3848	Pyruvate phosphate dikinase
GWR21_RS29645	COG0574	Belongs to the PEP-utilizing enzyme family
GWR21_RS29655	COG2354	Protein conserved in bacteria
GWR21_RS29690	COG0640	Transcriptional regulator
GWR21_RS29720	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWR21_RS29790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWR21_RS29805	COG0655	NAD(P)H dehydrogenase (quinone) activity
GWR21_RS29820	COG4771	TonB-dependent receptor
GWR21_RS29835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS29845	COG4771	TonB-dependent receptor
GWR21_RS29860	COG2133	pyrroloquinoline quinone binding
GWR21_RS29865	COG3040	lipid binding
GWR21_RS29870	COG3275	phosphorelay sensor kinase activity
GWR21_RS29890	COG2814	Major facilitator Superfamily
GWR21_RS29920	COG2267	carboxylic ester hydrolase activity
GWR21_RS29945	COG1131	(ABC) transporter
GWR21_RS29960	COG2814	Major facilitator Superfamily
GWR21_RS30025	COG0277	FAD linked oxidase domain protein
GWR21_RS30030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWR21_RS30045	COG1595	DNA-templated transcription, initiation
GWR21_RS30055	COG1629	transport
GWR21_RS30095	COG3059	membrane
GWR21_RS30105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWR21_RS30120	COG2319	Wd-40 repeat
GWR21_RS30120	COG4249	Peptidase C14 caspase catalytic subunit p20
GWR21_RS30130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GWR21_RS30225	COG1192	Involved in chromosome partitioning
GWR21_RS30235	COG1222	aaa ATPase
GWR21_RS30260	COG1131	(ABC) transporter
GWR21_RS30265	COG3275	phosphorelay sensor kinase activity
GWR21_RS30270	COG3279	Response regulator of the LytR AlgR family
GWR21_RS30290	COG2267	carboxylic ester hydrolase activity
GWR21_RS30345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GWR21_RS30355	COG3209	COG3209 Rhs family protein
GWR21_RS30365	COG1063	alcohol dehydrogenase
GWR21_RS30375	COG0300	oxidoreductase activity
GWR21_RS30390	COG1629	transport
GWR21_RS30435	COG0248	Ppx GppA phosphatase
GWR21_RS30475	COG1733	regulation of RNA biosynthetic process
GWR21_RS30495	COG2909	trisaccharide binding
GWR21_RS30500	COG2207	Transcriptional regulator
GWR21_RS30500	COG1917	Cupin 2, conserved barrel domain protein
GWR21_RS30505	COG0667	Aldo Keto reductase
GWR21_RS30520	COG3250	beta-galactosidase activity
GWR21_RS30530	COG0702	epimerase
GWR21_RS30535	COG4771	TonB-dependent receptor
GWR21_RS30560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWR21_RS30575	COG0633	Ferredoxin
GWR21_RS30595	COG2274	protein secretion by the type I secretion system
GWR21_RS30625	COG0702	epimerase
GWR21_RS30630	COG1629	transport
GWR21_RS30680	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GWR21_RS30710	COG0006	proline dipeptidase activity
GWR21_RS30755	COG1609	Transcriptional regulator
GWR21_RS30760	COG1629	transport
GWR21_RS30760	COG4206	TonB-dependent receptor
GWR21_RS30765	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GWR21_RS30775	COG0366	Alpha amylase catalytic
GWR21_RS30780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWR21_RS30805	COG0702	epimerase
GWR21_RS30815	COG2272	Belongs to the type-B carboxylesterase lipase family
GWR21_RS30860	COG1252	NADH dehydrogenase
GWR21_RS30885	COG0484	heat shock protein binding
GWR21_RS30895	COG2205	protein histidine kinase activity
GWR21_RS30905	COG0659	secondary active sulfate transmembrane transporter activity
GWR21_RS30935	COG1546	Belongs to the CinA family
GWR21_RS30935	COG1058	Belongs to the CinA family
GWR21_RS30940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWR21_RS30940	COG0723	plastoquinol--plastocyanin reductase activity
GWR21_RS30945	COG1063	alcohol dehydrogenase
GWR21_RS30965	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWR21_RS30965	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GWR21_RS30970	COG0859	PFAM glycosyl transferase family 9
GWR21_RS30975	COG0859	PFAM glycosyl transferase family 9
GWR21_RS30985	COG2192	nodulation
GWR21_RS30995	COG3781	membrane
GWR21_RS31015	COG1028	Short-chain dehydrogenase reductase Sdr
GWR21_RS31020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GWR21_RS31025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GWR21_RS31030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWR21_RS31075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWR21_RS31105	COG0346	lactoylglutathione lyase activity
GWR21_RS31125	COG1741	Belongs to the pirin family
GWR21_RS31140	COG4221	oxidoreductase activity
GWR21_RS31150	COG2814	Major facilitator Superfamily
GWR21_RS31155	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GWR21_RS31160	COG1309	transcriptional regulator
GWR21_RS31165	COG2855	membrane
GWR21_RS31190	COG0427	acetyl-CoA hydrolase
GWR21_RS31195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GWR21_RS31215	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GWR21_RS31225	COG4771	TonB-dependent receptor
GWR21_RS31300	COG3328	transposase activity
GWR21_RS31330	COG2972	Histidine kinase
GWR21_RS31330	COG0745	RESPONSE REGULATOR receiver
GWR21_RS31350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GWR21_RS31355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWR21_RS31410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family