locus-tag	class	description
C6H94_RS00005	COG0113	porphobilinogen synthase activity
C6H94_RS00010	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C6H94_RS00020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6H94_RS00020	COG1747	RNA polymerase binding
C6H94_RS00030	COG1448	Aminotransferase
C6H94_RS00040	COG1074	ATP-dependent DNA helicase activity
C6H94_RS00050	COG2814	Major facilitator Superfamily
C6H94_RS00065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6H94_RS00070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6H94_RS00095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6H94_RS00100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C6H94_RS00110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6H94_RS00130	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C6H94_RS00150	COG0564	pseudouridine synthase activity
C6H94_RS00155	COG1837	Belongs to the UPF0109 family
C6H94_RS00170	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C6H94_RS00225	COG2815	serine threonine protein kinase
C6H94_RS00225	COG0515	serine threonine protein kinase
C6H94_RS00240	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C6H94_RS00260	COG0233	cytoplasmic translational termination
C6H94_RS00265	COG0528	UMP kinase activity
C6H94_RS00270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C6H94_RS00275	COG0052	Belongs to the universal ribosomal protein uS2 family
C6H94_RS00290	COG0768	penicillin binding
C6H94_RS00300	COG0719	Fe-S assembly protein
C6H94_RS00305	COG0396	ATPase activity
C6H94_RS00310	COG0719	Fe-S assembly protein
C6H94_RS00315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6H94_RS00320	COG1475	DNA binding
C6H94_RS00325	COG4608	Belongs to the ABC transporter superfamily
C6H94_RS00330	COG0444	Belongs to the ABC transporter superfamily
C6H94_RS00335	COG1392	Phosphate transport regulator
C6H94_RS00340	COG0306	phosphate transporter
C6H94_RS00345	COG0126	phosphoglycerate kinase activity
C6H94_RS00365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C6H94_RS00370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C6H94_RS00380	COG0688	phosphatidylethanolamine metabolic process
C6H94_RS00390	COG0653	protein targeting
C6H94_RS00400	COG1160	GTP binding
C6H94_RS00405	COG0617	tRNA 3'-terminal CCA addition
C6H94_RS00410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C6H94_RS00415	COG0740	serine-type endopeptidase activity
C6H94_RS00420	COG0544	peptidyl-prolyl cis-trans isomerase activity
C6H94_RS00435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6H94_RS00440	COG1077	Cell shape determining protein MreB Mrl
C6H94_RS00445	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C6H94_RS00465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6H94_RS00470	COG4284	Utp--glucose-1-phosphate uridylyltransferase
C6H94_RS00490	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C6H94_RS00505	COG0588	phosphoglycerate mutase activity
C6H94_RS00510	COG1187	pseudouridine synthase activity
C6H94_RS00525	COG0772	Belongs to the SEDS family
C6H94_RS00540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C6H94_RS00545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6H94_RS00545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6H94_RS00550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6H94_RS00550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6H94_RS00555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6H94_RS00570	COG1115	amino acid carrier protein
C6H94_RS00575	COG1881	PFAM PEBP family protein
C6H94_RS00585	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C6H94_RS00590	COG1674	ftsk spoiiie
C6H94_RS00625	COG2871	sodium ion transport
C6H94_RS00630	COG1862	Preprotein translocase
C6H94_RS00650	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C6H94_RS00655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6H94_RS00660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C6H94_RS00665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C6H94_RS00670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6H94_RS00695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C6H94_RS00705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6H94_RS00730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C6H94_RS00735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6H94_RS00740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C6H94_RS00750	COG0772	Belongs to the SEDS family
C6H94_RS00755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6H94_RS00760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6H94_RS00760	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6H94_RS00765	COG1837	Belongs to the UPF0109 family
C6H94_RS00775	COG1366	Belongs to the anti-sigma-factor antagonist family
C6H94_RS00780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6H94_RS00785	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C6H94_RS00795	COG0799	negative regulation of ribosome biogenesis
C6H94_RS00800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6H94_RS00810	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C6H94_RS00815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6H94_RS00830	COG0204	Acyl-transferase
C6H94_RS00830	COG0318	PFAM AMP-dependent synthetase and ligase
C6H94_RS00835	COG0156	8-amino-7-oxononanoate synthase activity
C6H94_RS00840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C6H94_RS00850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6H94_RS00855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6H94_RS00860	COG0215	cysteine-tRNA ligase activity
C6H94_RS00865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6H94_RS00870	COG0594	ribonuclease P activity
C6H94_RS00885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C6H94_RS00905	COG0322	excinuclease ABC activity
C6H94_RS00910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C6H94_RS00920	COG0358	DNA primase activity
C6H94_RS00935	COG0751	glycine-tRNA ligase activity
C6H94_RS00935	COG0752	glycyl-tRNA synthetase alpha subunit
C6H94_RS00945	COG0297	glycogen (starch) synthase activity
C6H94_RS00960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C6H94_RS00965	COG0193	aminoacyl-tRNA hydrolase activity
C6H94_RS00970	COG0360	Binds together with S18 to 16S ribosomal RNA
C6H94_RS00975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6H94_RS00980	COG0359	binds to the 23S rRNA
C6H94_RS00985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C6H94_RS01000	COG1025	Belongs to the peptidase M16 family
C6H94_RS01010	COG1530	ribonuclease E activity
C6H94_RS01025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C6H94_RS01030	COG0416	fatty acid biosynthetic process
C6H94_RS01035	COG4625	pathogenesis
C6H94_RS01035	COG3210	domain, Protein
C6H94_RS01055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6H94_RS01060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6H94_RS01065	COG0814	amino acid
C6H94_RS01070	COG0814	amino acid
C6H94_RS01075	COG0670	Belongs to the BI1 family
C6H94_RS01080	COG0552	protein localization to endoplasmic reticulum
C6H94_RS01085	COG0045	succinate-CoA ligase (ADP-forming) activity
C6H94_RS01090	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C6H94_RS01095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6H94_RS01105	COG1322	Protein conserved in bacteria
C6H94_RS01120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6H94_RS01120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C6H94_RS01125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6H94_RS01130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6H94_RS01140	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C6H94_RS01145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6H94_RS01150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6H94_RS01155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C6H94_RS01165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C6H94_RS01170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C6H94_RS01195	COG0037	tRNA processing
C6H94_RS01205	COG1185	polyribonucleotide nucleotidyltransferase activity
C6H94_RS01255	COG0024	Methionine aminopeptidase
C6H94_RS01260	COG2095	MarC family integral membrane protein
C6H94_RS01275	COG0114	fumarate hydratase activity
C6H94_RS01280	COG0659	secondary active sulfate transmembrane transporter activity
C6H94_RS01295	COG0793	Belongs to the peptidase S41A family
C6H94_RS01300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C6H94_RS01335	COG4974	Belongs to the 'phage' integrase family
C6H94_RS01345	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6H94_RS01370	COG3210	domain, Protein
C6H94_RS01375	COG3210	domain, Protein
C6H94_RS01380	COG3210	domain, Protein
C6H94_RS01385	COG3210	domain, Protein
C6H94_RS01395	COG3210	domain, Protein
C6H94_RS01410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6H94_RS01415	COG0154	amidase activity
C6H94_RS01420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6H94_RS01440	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6H94_RS01450	COG1560	Kdo2-lipid A biosynthetic process
C6H94_RS01460	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C6H94_RS01465	COG1271	oxidase subunit
C6H94_RS01470	COG1294	oxidase, subunit
C6H94_RS01475	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C6H94_RS01500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C6H94_RS01505	COG0681	Belongs to the peptidase S26 family
C6H94_RS01505	COG0681	Belongs to the peptidase S26 family
C6H94_RS01515	COG0254	rRNA binding
C6H94_RS01520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C6H94_RS01530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C6H94_RS01535	COG0228	four-way junction DNA binding
C6H94_RS01540	COG0346	lactoylglutathione lyase activity
C6H94_RS01540	COG0336	Belongs to the RNA methyltransferase TrmD family
C6H94_RS01545	COG0335	large ribosomal subunit rRNA binding
C6H94_RS01550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6H94_RS01555	COG0194	GDP metabolic process
C6H94_RS01565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6H94_RS01570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6H94_RS01580	COG4285	Biotin-protein ligase, N terminal
C6H94_RS01600	COG0717	Belongs to the dCTP deaminase family
C6H94_RS01605	COG2255	four-way junction helicase activity
C6H94_RS01610	COG2385	sporulation resulting in formation of a cellular spore
C6H94_RS01625	COG0629	single-stranded DNA binding
C6H94_RS01630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C6H94_RS01645	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C6H94_RS01665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6H94_RS01680	COG0567	Dehydrogenase, E1 component
C6H94_RS01680	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6H94_RS01685	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6H94_RS01695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C6H94_RS01705	COG0633	Ferredoxin
C6H94_RS01715	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C6H94_RS01720	COG1191	sigma factor activity
C6H94_RS01725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6H94_RS01730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C6H94_RS01735	COG0481	GTPase activity
C6H94_RS01740	COG3202	ADP transmembrane transporter activity
C6H94_RS01760	COG0803	Belongs to the bacterial solute-binding protein 9 family
C6H94_RS01765	COG1121	(ABC) transporter
C6H94_RS01770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6H94_RS01770	COG1321	iron dependent repressor
C6H94_RS01775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6H94_RS01780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C6H94_RS01785	COG0750	zinc metalloprotease
C6H94_RS01795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6H94_RS01800	COG0592	DNA-directed DNA polymerase activity
C6H94_RS01805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C6H94_RS01810	COG1477	protein flavinylation
C6H94_RS01815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6H94_RS01845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6H94_RS01850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C6H94_RS01855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6H94_RS01860	COG1640	4-alpha-glucanotransferase
C6H94_RS01875	COG4789	Type iii secretion
C6H94_RS01880	COG4792	protein secretion
C6H94_RS01885	COG0012	GTP binding
C6H94_RS01890	COG0196	riboflavin kinase activity
C6H94_RS01900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C6H94_RS01905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C6H94_RS01910	COG0195	Participates in both transcription termination and antitermination
C6H94_RS01915	COG0539	negative regulation of cytoplasmic translation
C6H94_RS01920	COG0492	ferredoxin-NADP+ reductase activity
C6H94_RS01925	COG0736	holo-[acyl-carrier-protein] synthase activity
C6H94_RS01945	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C6H94_RS01955	COG0564	pseudouridine synthase activity
C6H94_RS01965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C6H94_RS01975	COG0459	protein refolding
C6H94_RS01980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6H94_RS01985	COG1164	Oligoendopeptidase f
C6H94_RS01990	COG0542	response to heat
C6H94_RS02030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C6H94_RS02035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6H94_RS02040	COG0511	ligase activity, forming carbon-carbon bonds
C6H94_RS02045	COG0439	Biotin carboxylase
C6H94_RS02050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C6H94_RS02055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C6H94_RS02065	COG0563	adenylate kinase activity
C6H94_RS02070	COG0765	amino acid transport
C6H94_RS02075	COG1126	abc transporter atp-binding protein
C6H94_RS02110	COG0009	L-threonylcarbamoyladenylate synthase
C6H94_RS02120	COG4166	transmembrane transport
C6H94_RS02130	COG3318	Belongs to the UPF0149 family
C6H94_RS02130	COG3012	SEC-C Motif Domain Protein
C6H94_RS02160	COG0515	serine threonine protein kinase
C6H94_RS02160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C6H94_RS02165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6H94_RS02175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6H94_RS02190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6H94_RS02200	COG1136	(ABC) transporter
C6H94_RS02235	COG3774	pathogenesis
C6H94_RS02235	COG5263	repeat protein
C6H94_RS02245	COG5263	repeat protein
C6H94_RS02245	COG3774	pathogenesis
C6H94_RS02255	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6H94_RS02260	COG0519	Catalyzes the synthesis of GMP from XMP
C6H94_RS02265	COG0516	GMP reductase activity
C6H94_RS02265	COG0517	IMP dehydrogenase activity
C6H94_RS02280	COG4166	transmembrane transport
C6H94_RS02290	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C6H94_RS02310	COG1116	anion transmembrane transporter activity
C6H94_RS02330	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C6H94_RS02335	COG0504	CTP synthase activity
C6H94_RS02340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C6H94_RS02345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C6H94_RS02350	COG0363	glucosamine-6-phosphate deaminase activity
C6H94_RS02355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C6H94_RS02360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6H94_RS02365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6H94_RS02370	COG0187	DNA topoisomerase II activity
C6H94_RS02385	COG0343	queuine tRNA-ribosyltransferase activity
C6H94_RS02390	COG2239	Acts as a magnesium transporter
C6H94_RS02405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C6H94_RS02410	COG4166	transmembrane transport
C6H94_RS02415	COG0601	transmembrane transport
C6H94_RS02420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6H94_RS02425	COG0444	Belongs to the ABC transporter superfamily
C6H94_RS02435	COG3012	SEC-C Motif Domain Protein
C6H94_RS02440	COG0471	metal ion transport
C6H94_RS02445	COG0205	6-phosphofructokinase activity
C6H94_RS02470	COG1519	Transferase
C6H94_RS02475	COG0495	leucyl-tRNA aminoacylation
C6H94_RS02480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C6H94_RS02485	COG1678	Uncharacterized ACR, COG1678
C6H94_RS02495	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C6H94_RS02510	COG1830	Aldolase
C6H94_RS02515	COG0531	amino acid
C6H94_RS02520	COG0037	tRNA processing
C6H94_RS02525	COG0210	DNA helicase
C6H94_RS02530	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C6H94_RS02535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6H94_RS02540	COG0163	prenyltransferase activity
C6H94_RS02545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C6H94_RS02595	COG1823	symporter activity
C6H94_RS02600	COG0733	neurotransmitter:sodium symporter activity
C6H94_RS02625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6H94_RS02630	COG1028	Short-chain dehydrogenase reductase Sdr
C6H94_RS02635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C6H94_RS02640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6H94_RS02645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C6H94_RS02650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6H94_RS02655	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C6H94_RS02660	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6H94_RS02670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C6H94_RS02675	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6H94_RS02675	COG0022	dehydrogenase e1 component
C6H94_RS02680	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6H94_RS02685	COG0058	SHG alpha-glucan phosphorylase activity
C6H94_RS02695	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6H94_RS02700	COG0706	membrane insertase activity
C6H94_RS02705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C6H94_RS02715	COG1266	CAAX protease self-immunity
C6H94_RS02730	COG4536	flavin adenine dinucleotide binding
C6H94_RS02740	COG1104	cysteine desulfurase activity
C6H94_RS02745	COG0631	protein serine/threonine phosphatase activity
C6H94_RS02755	COG2176	DNA-directed DNA polymerase activity
C6H94_RS02760	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
C6H94_RS02770	COG1132	(ABC) transporter
C6H94_RS02775	COG0825	malonyl-CoA metabolic process
C6H94_RS02790	COG0860	N-Acetylmuramoyl-L-alanine amidase
C6H94_RS02795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6H94_RS02815	COG0275	rRNA processing
C6H94_RS02830	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6H94_RS02845	COG1805	sodium ion transport
C6H94_RS02850	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C6H94_RS02855	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C6H94_RS02860	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C6H94_RS02865	COG0509	glycine decarboxylation via glycine cleavage system
C6H94_RS02885	COG0542	response to heat
C6H94_RS02890	COG0482	sulfurtransferase activity
C6H94_RS02910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6H94_RS02915	COG0756	dUTP diphosphatase activity
C6H94_RS02920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C6H94_RS02925	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C6H94_RS02930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6H94_RS02940	COG0571	ribonuclease III activity
C6H94_RS02945	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C6H94_RS02950	COG0181	hydroxymethylbilane synthase activity
C6H94_RS02960	COG0515	serine threonine protein kinase
C6H94_RS02965	COG0525	valine-tRNA ligase activity
C6H94_RS02980	COG1269	ATP hydrolysis coupled proton transport
C6H94_RS02985	COG1394	ATPase activity, coupled to movement of substances
C6H94_RS02990	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
C6H94_RS02995	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
C6H94_RS03005	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
C6H94_RS03020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6H94_RS03025	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C6H94_RS03030	COG0085	RNA polymerase activity
C6H94_RS03035	COG0222	ribosome binding
C6H94_RS03040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C6H94_RS03045	COG0081	regulation of translation
C6H94_RS03050	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C6H94_RS03055	COG0250	Participates in transcription elongation, termination and antitermination
C6H94_RS03070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6H94_RS03110	COG0135	phosphoribosylanthranilate isomerase activity
C6H94_RS03115	COG0149	triose-phosphate isomerase activity
C6H94_RS03120	COG1570	exodeoxyribonuclease VII activity
C6H94_RS03125	COG1722	exodeoxyribonuclease VII activity
C6H94_RS03135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6H94_RS03140	COG0469	pyruvate kinase activity
C6H94_RS03145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6H94_RS03150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C6H94_RS03155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C6H94_RS03160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6H94_RS03165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6H94_RS03185	COG0022	dehydrogenase e1 component
C6H94_RS03190	COG0484	heat shock protein binding
C6H94_RS03200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C6H94_RS03205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C6H94_RS03215	COG1234	tRNA 3'-trailer cleavage
C6H94_RS03220	COG4974	Belongs to the 'phage' integrase family
C6H94_RS03225	COG0488	(ABC) transporter
C6H94_RS03230	COG0424	maF-like protein
C6H94_RS03250	COG0242	peptide deformylase activity
C6H94_RS03255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6H94_RS03260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6H94_RS03265	COG1331	Highly conserved protein containing a thioredoxin domain
C6H94_RS03295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6H94_RS03300	COG0527	aspartate kinase activity
C6H94_RS03310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C6H94_RS03320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6H94_RS03325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6H94_RS03330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6H94_RS03335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6H94_RS03340	COG0710	3-dehydroquinate dehydratase activity
C6H94_RS03340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6H94_RS03345	COG0546	phosphoglycolate phosphatase activity
C6H94_RS03350	COG3659	wide pore channel activity
C6H94_RS03355	COG1945	arginine decarboxylase activity
C6H94_RS03360	COG0531	amino acid
C6H94_RS03370	COG0039	L-malate dehydrogenase activity
C6H94_RS03380	COG0166	Belongs to the GPI family
C6H94_RS03385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6H94_RS03390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C6H94_RS03390	COG0321	lipoyl(octanoyl) transferase activity
C6H94_RS03400	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C6H94_RS03400	COG1605	Chorismate mutase
C6H94_RS03420	COG0537	adenosine 5'-monophosphoramidase activity
C6H94_RS03425	COG4286	Uncharacterised protein family (UPF0160)
C6H94_RS03435	COG1872	DUF167
C6H94_RS03445	COG0436	Aminotransferase
C6H94_RS03460	COG0442	prolyl-tRNA aminoacylation
C6H94_RS03465	COG1420	regulation of RNA biosynthetic process
C6H94_RS03470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C6H94_RS03475	COG0443	Heat shock 70 kDa protein
C6H94_RS03480	COG0557	exoribonuclease II activity
C6H94_RS03495	COG0517	IMP dehydrogenase activity
C6H94_RS03495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C6H94_RS03500	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6H94_RS03505	COG1301	dicarboxylic acid transport
C6H94_RS03510	COG1663	tetraacyldisaccharide 4'-kinase activity
C6H94_RS03515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6H94_RS03525	COG0307	riboflavin synthase, alpha
C6H94_RS03530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C6H94_RS03535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C6H94_RS03540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6H94_RS03545	COG1115	amino acid carrier protein
C6H94_RS03550	COG0617	tRNA 3'-terminal CCA addition
C6H94_RS03555	COG3952	Lipid A Biosynthesis
C6H94_RS03555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6H94_RS03560	COG4625	pathogenesis
C6H94_RS03565	COG3210	domain, Protein
C6H94_RS03570	COG3210	domain, Protein
C6H94_RS03580	COG0803	Belongs to the bacterial solute-binding protein 9 family
C6H94_RS03585	COG1121	(ABC) transporter
C6H94_RS03590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6H94_RS03595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C6H94_RS03605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C6H94_RS03630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6H94_RS03640	COG1366	Belongs to the anti-sigma-factor antagonist family
C6H94_RS03645	COG4692	amylo-alpha-1,6-glucosidase activity
C6H94_RS03655	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C6H94_RS03665	COG2226	methyltransferase
C6H94_RS03675	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C6H94_RS03680	COG0740	serine-type endopeptidase activity
C6H94_RS03685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6H94_RS03695	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C6H94_RS03700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C6H94_RS03710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6H94_RS03715	COG0049	tRNA binding
C6H94_RS03730	COG0793	Belongs to the peptidase S41A family
C6H94_RS03745	COG1361	Conserved repeat domain
C6H94_RS03760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6H94_RS03770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C6H94_RS03770	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C6H94_RS03775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6H94_RS03775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6H94_RS03785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6H94_RS03790	COG0575	Belongs to the CDS family
C6H94_RS03795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6H94_RS03800	COG0318	PFAM AMP-dependent synthetase and ligase
C6H94_RS03800	COG0204	Acyl-transferase
C6H94_RS03805	COG0018	arginyl-trna synthetase
C6H94_RS03810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6H94_RS03820	COG0217	transcriptional regulatory protein
C6H94_RS03825	COG1247	-acetyltransferase
C6H94_RS03840	COG1408	metallophosphoesterase
C6H94_RS03845	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C6H94_RS03855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6H94_RS03875	COG4191	Histidine kinase
C6H94_RS03880	COG2204	response regulator
C6H94_RS03895	COG1381	Involved in DNA repair and RecF pathway recombination
C6H94_RS03915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C6H94_RS03920	COG1388	LysM domain
C6H94_RS03925	COG0072	phenylalanine-tRNA ligase activity
C6H94_RS03925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6H94_RS03940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6H94_RS03945	COG0601	transmembrane transport
C6H94_RS03975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C6H94_RS03985	COG0742	ribosomal rna small subunit methyltransferase
C6H94_RS03995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C6H94_RS04005	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C6H94_RS04010	COG0237	dephospho-CoA kinase activity
C6H94_RS04015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6H94_RS04015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6H94_RS04020	COG0616	signal peptide processing
C6H94_RS04025	COG3202	ADP transmembrane transporter activity
C6H94_RS04030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6H94_RS04040	COG0305	Participates in initiation and elongation during chromosome replication
C6H94_RS04050	COG0445	tRNA wobble uridine modification
C6H94_RS04060	COG0105	UTP biosynthetic process
C6H94_RS04065	COG0632	four-way junction helicase activity
C6H94_RS04070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C6H94_RS04090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6H94_RS04095	COG0203	ribosomal protein L17
C6H94_RS04100	COG0202	RNA polymerase activity
C6H94_RS04105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C6H94_RS04110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C6H94_RS04115	COG0201	protein transport
C6H94_RS04120	COG0200	Binds to the 23S rRNA
C6H94_RS04130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C6H94_RS04135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C6H94_RS04140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C6H94_RS04145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C6H94_RS04155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C6H94_RS04160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C6H94_RS04165	COG0255	Belongs to the universal ribosomal protein uL29 family
C6H94_RS04175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C6H94_RS04180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C6H94_RS04190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C6H94_RS04195	COG0089	rRNA binding
C6H94_RS04200	COG0088	Forms part of the polypeptide exit tunnel
C6H94_RS04205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C6H94_RS04215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6H94_RS04220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6H94_RS04225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6H94_RS04230	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C6H94_RS04235	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C6H94_RS04240	COG1607	acyl-coa hydrolase
C6H94_RS04245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6H94_RS04265	COG3118	belongs to the thioredoxin family
C6H94_RS04270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C6H94_RS04275	COG0545	Peptidyl-prolyl cis-trans isomerase
C6H94_RS04280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C6H94_RS04285	COG0124	histidyl-tRNA synthetase
C6H94_RS04290	COG2271	Major facilitator Superfamily
C6H94_RS04295	COG0587	DNA-directed DNA polymerase activity
C6H94_RS04300	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C6H94_RS04330	COG1686	Belongs to the peptidase S11 family
C6H94_RS04345	COG1114	Component of the transport system for branched-chain amino acids
C6H94_RS04360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6H94_RS04365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C6H94_RS04370	COG4669	(LipO)protein
C6H94_RS04395	COG1987	bacterial-type flagellum assembly
C6H94_RS04400	COG4791	protein targeting
C6H94_RS04425	COG2165	general secretion pathway protein
C6H94_RS04430	COG1459	type II secretion system
C6H94_RS04435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C6H94_RS04450	COG0006	proline dipeptidase activity
C6H94_RS04455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C6H94_RS04480	COG0697	spore germination
C6H94_RS04485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6H94_RS04490	COG1192	Involved in chromosome partitioning
C6H94_RS04505	COG0180	Tryptophanyl-tRNA synthetase
C6H94_RS04510	COG0556	nucleotide-excision repair
C6H94_RS04515	COG0148	phosphopyruvate hydratase activity
C6H94_RS04535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C6H94_RS04540	COG1053	succinate dehydrogenase
C6H94_RS04550	COG0084	hydrolase, TatD family'
C6H94_RS04555	COG4232	protein-disulfide reductase activity
C6H94_RS04560	COG0811	peptide transport
C6H94_RS04575	COG0823	Involved in the tonB-independent uptake of proteins
C6H94_RS04585	COG4641	Protein conserved in bacteria
C6H94_RS04585	COG1388	LysM domain
C6H94_RS04595	COG0450	alkyl hydroperoxide reductase
C6H94_RS04605	COG0459	protein refolding
C6H94_RS04610	COG3876	Protein conserved in bacteria
C6H94_RS04615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6H94_RS04625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C6H94_RS04630	COG0210	DNA helicase
C6H94_RS04640	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C6H94_RS04645	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C6H94_RS04645	COG0778	Nitroreductase
C6H94_RS04655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C6H94_RS04655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6H94_RS04660	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C6H94_RS04665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6H94_RS04670	COG0497	DNA recombination
C6H94_RS04680	COG0268	Binds directly to 16S ribosomal RNA
C6H94_RS04720	COG0728	peptidoglycan biosynthetic process
C6H94_RS04725	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C6H94_RS04730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C6H94_RS04735	COG1054	Belongs to the UPF0176 family
C6H94_RS04740	COG0142	geranyltranstransferase activity
C6H94_RS04745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6H94_RS04765	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant