locus-tag	class	description
B711_RS00005	COG0113	porphobilinogen synthase activity
B711_RS00010	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B711_RS00055	COG1054	Belongs to the UPF0176 family
B711_RS00060	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B711_RS00065	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B711_RS00070	COG0728	peptidoglycan biosynthetic process
B711_RS00120	COG1837	Belongs to the UPF0109 family
B711_RS00125	COG0564	pseudouridine synthase activity
B711_RS00200	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B711_RS00205	COG2815	serine threonine protein kinase
B711_RS00205	COG0515	serine threonine protein kinase
B711_RS00220	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B711_RS00225	COG3880	PFAM UvrB UvrC protein
B711_RS00240	COG0233	cytoplasmic translational termination
B711_RS00245	COG0528	UMP kinase activity
B711_RS00250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B711_RS00255	COG0052	Belongs to the universal ribosomal protein uS2 family
B711_RS00280	COG0719	Fe-S assembly protein
B711_RS00285	COG0396	ATPase activity
B711_RS00290	COG0719	Fe-S assembly protein
B711_RS00295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B711_RS00310	COG1475	DNA binding
B711_RS00315	COG4608	Belongs to the ABC transporter superfamily
B711_RS00320	COG0444	Belongs to the ABC transporter superfamily
B711_RS00325	COG1392	Phosphate transport regulator
B711_RS00330	COG0306	phosphate transporter
B711_RS00335	COG0126	phosphoglycerate kinase activity
B711_RS00365	COG1686	Belongs to the peptidase S11 family
B711_RS00395	COG0587	DNA-directed DNA polymerase activity
B711_RS00415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B711_RS00420	COG0545	Peptidyl-prolyl cis-trans isomerase
B711_RS00430	COG3118	belongs to the thioredoxin family
B711_RS00450	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B711_RS00455	COG1607	acyl-coa hydrolase
B711_RS00460	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B711_RS00465	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B711_RS00470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B711_RS00475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B711_RS00480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B711_RS00490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B711_RS00495	COG0088	Forms part of the polypeptide exit tunnel
B711_RS00500	COG0089	rRNA binding
B711_RS00505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B711_RS00510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B711_RS00515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B711_RS00520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B711_RS00525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B711_RS00530	COG0255	Belongs to the universal ribosomal protein uL29 family
B711_RS00535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B711_RS00540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B711_RS00545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B711_RS00550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B711_RS00555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B711_RS00560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B711_RS00565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B711_RS00570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B711_RS00575	COG0200	Binds to the 23S rRNA
B711_RS00585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B711_RS00590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B711_RS00595	COG0202	RNA polymerase activity
B711_RS00600	COG0203	ribosomal protein L17
B711_RS00605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B711_RS00625	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B711_RS00630	COG0632	four-way junction helicase activity
B711_RS00635	COG0105	UTP biosynthetic process
B711_RS00645	COG0445	tRNA wobble uridine modification
B711_RS00650	COG0305	Participates in initiation and elongation during chromosome replication
B711_RS00660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B711_RS00665	COG3202	ADP transmembrane transporter activity
B711_RS00675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B711_RS00675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B711_RS00680	COG0237	dephospho-CoA kinase activity
B711_RS00685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B711_RS00695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B711_RS00700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B711_RS00710	COG0742	ribosomal rna small subunit methyltransferase
B711_RS00720	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B711_RS00750	COG0601	transmembrane transport
B711_RS00755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B711_RS00760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B711_RS00770	COG0072	phenylalanine-tRNA ligase activity
B711_RS00770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B711_RS00775	COG1388	LysM domain
B711_RS00795	COG1381	Involved in DNA repair and RecF pathway recombination
B711_RS00815	COG2204	response regulator
B711_RS00825	COG4191	Histidine kinase
B711_RS00850	COG0101	tRNA pseudouridine synthase activity
B711_RS00855	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B711_RS00860	COG1408	metallophosphoesterase
B711_RS00885	COG0217	transcriptional regulatory protein
B711_RS00895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B711_RS00900	COG0018	arginyl-trna synthetase
B711_RS00910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B711_RS00915	COG0575	Belongs to the CDS family
B711_RS00930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B711_RS00930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B711_RS00935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B711_RS00965	COG1361	Conserved repeat domain
B711_RS00975	COG0793	Belongs to the peptidase S41A family
B711_RS00990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B711_RS00995	COG0049	tRNA binding
B711_RS01000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B711_RS01005	COG0051	transcription antitermination factor activity, RNA binding
B711_RS01015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B711_RS01030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B711_RS01035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B711_RS01040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B711_RS01045	COG1121	(ABC) transporter
B711_RS01050	COG0803	Belongs to the bacterial solute-binding protein 9 family
B711_RS01060	COG0352	thiamine-phosphate diphosphorylase activity
B711_RS01065	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B711_RS01070	COG3210	domain, Protein
B711_RS01075	COG4625	pathogenesis
B711_RS01090	COG1115	amino acid carrier protein
B711_RS01095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B711_RS01100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B711_RS01105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B711_RS01110	COG0307	riboflavin synthase, alpha
B711_RS01125	COG1663	tetraacyldisaccharide 4'-kinase activity
B711_RS01130	COG1301	dicarboxylic acid transport
B711_RS01135	COG0508	dehydrogenase complex catalyzes the overall conversion of
B711_RS01140	COG0517	IMP dehydrogenase activity
B711_RS01140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B711_RS01165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B711_RS01170	COG0740	serine-type endopeptidase activity
B711_RS01175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B711_RS01185	COG2226	methyltransferase
B711_RS01195	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B711_RS01205	COG4692	amylo-alpha-1,6-glucosidase activity
B711_RS01210	COG1366	Belongs to the anti-sigma-factor antagonist family
B711_RS01220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B711_RS01230	COG2094	Belongs to the DNA glycosylase MPG family
B711_RS01235	COG0557	exoribonuclease II activity
B711_RS01245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B711_RS01250	COG1420	regulation of RNA biosynthetic process
B711_RS01255	COG0442	prolyl-tRNA aminoacylation
B711_RS01270	COG1872	DUF167
B711_RS01280	COG0436	Aminotransferase
B711_RS01300	COG4286	Uncharacterised protein family (UPF0160)
B711_RS01305	COG0537	adenosine 5'-monophosphoramidase activity
B711_RS01330	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B711_RS01345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B711_RS01355	COG0321	lipoyl(octanoyl) transferase activity
B711_RS01355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B711_RS01360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B711_RS01380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B711_RS01395	COG3210	domain, Protein
B711_RS01400	COG3210	domain, Protein
B711_RS01410	COG3210	domain, Protein
B711_RS01430	COG3210	domain, Protein
B711_RS01440	COG3210	domain, Protein
B711_RS01450	COG4625	pathogenesis
B711_RS01455	COG4625	pathogenesis
B711_RS01480	COG3210	domain, Protein
B711_RS01485	COG3468	outer membrane autotransporter barrel domain protein
B711_RS01495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B711_RS01500	COG0154	amidase activity
B711_RS01505	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B711_RS01525	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B711_RS01550	COG0546	phosphoglycolate phosphatase activity
B711_RS01560	COG1331	Highly conserved protein containing a thioredoxin domain
B711_RS01565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B711_RS01570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B711_RS01575	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B711_RS01585	COG1722	exodeoxyribonuclease VII activity
B711_RS01590	COG1570	exodeoxyribonuclease VII activity
B711_RS01595	COG0149	triose-phosphate isomerase activity
B711_RS01605	COG0242	peptide deformylase activity
B711_RS01620	COG0424	maF-like protein
B711_RS01625	COG0488	(ABC) transporter
B711_RS01635	COG1234	tRNA 3'-trailer cleavage
B711_RS01645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B711_RS01650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B711_RS01655	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B711_RS01660	COG0484	heat shock protein binding
B711_RS01685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B711_RS01690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B711_RS01695	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B711_RS01700	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B711_RS01705	COG1480	7TM receptor with intracellular HD hydrolase
B711_RS01725	COG0181	hydroxymethylbilane synthase activity
B711_RS01730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B711_RS01735	COG0571	ribonuclease III activity
B711_RS01745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B711_RS01750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B711_RS01760	COG0756	dUTP diphosphatase activity
B711_RS01765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B711_RS01770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B711_RS01795	COG0482	sulfurtransferase activity
B711_RS01800	COG0542	response to heat
B711_RS01810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B711_RS01825	COG0509	glycine decarboxylation via glycine cleavage system
B711_RS01840	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B711_RS01850	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B711_RS01855	COG1805	sodium ion transport
B711_RS01870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B711_RS01885	COG0275	rRNA processing
B711_RS01895	COG0768	penicillin binding
B711_RS01905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B711_RS01920	COG0776	regulation of translation
B711_RS01935	COG0825	malonyl-CoA metabolic process
B711_RS01940	COG1132	(ABC) transporter
B711_RS01950	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B711_RS01975	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B711_RS01990	COG0564	pseudouridine synthase activity
B711_RS02005	COG1266	CAAX protease self-immunity
B711_RS02030	COG0631	protein serine/threonine phosphatase activity
B711_RS02035	COG1104	cysteine desulfurase activity
B711_RS02040	COG4535	Mg2 and Co2 transporter CorC
B711_RS02045	COG4536	flavin adenine dinucleotide binding
B711_RS02055	COG0717	Belongs to the dCTP deaminase family
B711_RS02060	COG2255	four-way junction helicase activity
B711_RS02065	COG2385	sporulation resulting in formation of a cellular spore
B711_RS02080	COG0629	single-stranded DNA binding
B711_RS02085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B711_RS02120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B711_RS02145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B711_RS02165	COG0633	Ferredoxin
B711_RS02180	COG1191	sigma factor activity
B711_RS02190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B711_RS02195	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B711_RS02200	COG0481	GTPase activity
B711_RS02210	COG3202	ADP transmembrane transporter activity
B711_RS02240	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B711_RS02245	COG0750	zinc metalloprotease
B711_RS02255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B711_RS02260	COG0592	DNA-directed DNA polymerase activity
B711_RS02265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B711_RS02270	COG1477	protein flavinylation
B711_RS02275	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B711_RS02300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B711_RS02305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B711_RS02310	COG1640	4-alpha-glucanotransferase
B711_RS02325	COG4789	Type iii secretion
B711_RS02330	COG4792	protein secretion
B711_RS02335	COG0012	GTP binding
B711_RS02340	COG0196	riboflavin kinase activity
B711_RS02345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B711_RS02350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B711_RS02355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B711_RS02360	COG2251	uridine kinase activity
B711_RS02360	COG0195	Participates in both transcription termination and antitermination
B711_RS02365	COG2183	response to ionizing radiation
B711_RS02365	COG0539	negative regulation of cytoplasmic translation
B711_RS02375	COG0736	holo-[acyl-carrier-protein] synthase activity
B711_RS02385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B711_RS02390	COG0706	membrane insertase activity
B711_RS02395	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B711_RS02405	COG0058	SHG alpha-glucan phosphorylase activity
B711_RS02410	COG0508	dehydrogenase complex catalyzes the overall conversion of
B711_RS02415	COG0508	dehydrogenase complex catalyzes the overall conversion of
B711_RS02415	COG0022	dehydrogenase e1 component
B711_RS02420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B711_RS02430	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B711_RS02440	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B711_RS02445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B711_RS02450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B711_RS02455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B711_RS02465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B711_RS02490	COG0733	neurotransmitter:sodium symporter activity
B711_RS02495	COG1823	symporter activity
B711_RS02510	COG2239	Acts as a magnesium transporter
B711_RS02520	COG0531	amino acid
B711_RS02525	COG1830	Aldolase
B711_RS02535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B711_RS02540	COG2011	ABC-type metal ion transport system permease component
B711_RS02545	COG1464	Belongs to the NlpA lipoprotein family
B711_RS02560	COG0187	DNA topoisomerase II activity
B711_RS02565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B711_RS02585	COG0009	L-threonylcarbamoyladenylate synthase
B711_RS02610	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B711_RS02620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B711_RS02640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B711_RS02650	COG0653	protein targeting
B711_RS02685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B711_RS02695	COG1136	(ABC) transporter
B711_RS02705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B711_RS02710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B711_RS02720	COG0563	adenylate kinase activity
B711_RS02740	COG0363	glucosamine-6-phosphate deaminase activity
B711_RS02745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B711_RS02750	COG4166	transmembrane transport
B711_RS02755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B711_RS02760	COG1438	arginine binding
B711_RS02765	COG0765	amino acid transport
B711_RS02770	COG1126	abc transporter atp-binding protein
B711_RS02785	COG1295	ribonuclease BN
B711_RS02805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B711_RS02810	COG0511	ligase activity, forming carbon-carbon bonds
B711_RS02820	COG0439	Biotin carboxylase
B711_RS02900	COG0519	Catalyzes the synthesis of GMP from XMP
B711_RS02905	COG0516	GMP reductase activity
B711_RS02905	COG0517	IMP dehydrogenase activity
B711_RS02965	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B711_RS02985	COG1116	anion transmembrane transporter activity
B711_RS03010	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B711_RS03020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B711_RS03025	COG4166	transmembrane transport
B711_RS03030	COG4166	transmembrane transport
B711_RS03035	COG4166	transmembrane transport
B711_RS03040	COG0601	transmembrane transport
B711_RS03045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B711_RS03050	COG0444	Belongs to the ABC transporter superfamily
B711_RS03060	COG3012	SEC-C Motif Domain Protein
B711_RS03065	COG0471	metal ion transport
B711_RS03070	COG0205	6-phosphofructokinase activity
B711_RS03100	COG0495	leucyl-tRNA aminoacylation
B711_RS03105	COG0495	leucyl-tRNA aminoacylation
B711_RS03125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B711_RS03130	COG0515	serine threonine protein kinase
B711_RS03130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B711_RS03180	COG1116	anion transmembrane transporter activity
B711_RS03185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B711_RS03190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B711_RS03195	COG1678	Uncharacterized ACR, COG1678
B711_RS03205	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B711_RS03225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B711_RS03230	COG1164	Oligoendopeptidase f
B711_RS03235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B711_RS03240	COG0459	protein refolding
B711_RS03260	COG4285	Biotin-protein ligase, N terminal
B711_RS03270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B711_RS03275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B711_RS03285	COG0194	GDP metabolic process
B711_RS03290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B711_RS03295	COG0335	large ribosomal subunit rRNA binding
B711_RS03305	COG0228	four-way junction DNA binding
B711_RS03310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B711_RS03320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B711_RS03325	COG0254	rRNA binding
B711_RS03340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B711_RS03350	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B711_RS03375	COG1271	oxidase subunit
B711_RS03380	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B711_RS03400	COG0469	pyruvate kinase activity
B711_RS03405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B711_RS03410	COG0515	serine threonine protein kinase
B711_RS03415	COG0525	valine-tRNA ligase activity
B711_RS03430	COG1269	ATP hydrolysis coupled proton transport
B711_RS03435	COG1394	ATPase activity, coupled to movement of substances
B711_RS03440	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
B711_RS03445	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
B711_RS03455	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
B711_RS03470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B711_RS03475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B711_RS03480	COG0085	RNA polymerase activity
B711_RS03485	COG0222	ribosome binding
B711_RS03490	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B711_RS03495	COG0081	regulation of translation
B711_RS03500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B711_RS03505	COG0250	Participates in transcription elongation, termination and antitermination
B711_RS03520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B711_RS03530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B711_RS03550	COG1268	BioY protein
B711_RS03575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B711_RS03580	COG0527	aspartate kinase activity
B711_RS03590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B711_RS03595	COG3186	Phenylalanine-4-hydroxylase
B711_RS03610	COG1028	Short-chain dehydrogenase reductase Sdr
B711_RS03615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B711_RS03620	COG0156	8-amino-7-oxononanoate synthase activity
B711_RS03625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B711_RS03630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B711_RS03645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B711_RS03650	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B711_RS03655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B711_RS03660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B711_RS03660	COG0710	3-dehydroquinate dehydratase activity
B711_RS03665	COG0546	phosphoglycolate phosphatase activity
B711_RS03670	COG3659	wide pore channel activity
B711_RS03675	COG1945	arginine decarboxylase activity
B711_RS03680	COG0531	amino acid
B711_RS03695	COG0039	L-malate dehydrogenase activity
B711_RS03705	COG0166	Belongs to the GPI family
B711_RS03710	COG4974	Belongs to the 'phage' integrase family
B711_RS03750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B711_RS03755	COG0793	Belongs to the peptidase S41A family
B711_RS03770	COG0114	fumarate hydratase activity
B711_RS03780	COG0563	adenylate kinase activity
B711_RS03790	COG2095	MarC family integral membrane protein
B711_RS03795	COG0024	Methionine aminopeptidase
B711_RS03840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B711_RS03845	COG1185	polyribonucleotide nucleotidyltransferase activity
B711_RS03855	COG0037	tRNA processing
B711_RS03880	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B711_RS03885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B711_RS03890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B711_RS03900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B711_RS03905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B711_RS03910	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B711_RS03920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B711_RS03925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B711_RS03925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B711_RS03930	COG1183	phosphatidylcholine synthase activity
B711_RS03935	COG1322	Protein conserved in bacteria
B711_RS03950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B711_RS03955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B711_RS03960	COG0045	succinate-CoA ligase (ADP-forming) activity
B711_RS03965	COG0552	protein localization to endoplasmic reticulum
B711_RS03970	COG0670	Belongs to the BI1 family
B711_RS03975	COG0814	amino acid
B711_RS03980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B711_RS03985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B711_RS03990	COG0617	tRNA 3'-terminal CCA addition
B711_RS03995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B711_RS03995	COG3952	Lipid A Biosynthesis
B711_RS04055	COG3210	domain, Protein
B711_RS04055	COG4625	pathogenesis
B711_RS04060	COG3210	domain, Protein
B711_RS04060	COG4625	pathogenesis
B711_RS04065	COG0416	fatty acid biosynthetic process
B711_RS04070	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B711_RS04080	COG1530	ribonuclease E activity
B711_RS04105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B711_RS04110	COG0359	binds to the 23S rRNA
B711_RS04115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B711_RS04120	COG0360	Binds together with S18 to 16S ribosomal RNA
B711_RS04125	COG0193	aminoacyl-tRNA hydrolase activity
B711_RS04130	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B711_RS04140	COG0297	glycogen (starch) synthase activity
B711_RS04155	COG0752	glycyl-tRNA synthetase alpha subunit
B711_RS04155	COG0751	glycine-tRNA ligase activity
B711_RS04180	COG0358	DNA primase activity
B711_RS04185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B711_RS04190	COG0322	excinuclease ABC activity
B711_RS04205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B711_RS04210	COG0594	ribonuclease P activity
B711_RS04215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B711_RS04220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B711_RS04225	COG0215	cysteine-tRNA ligase activity
B711_RS04230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B711_RS04235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B711_RS04245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B711_RS04250	COG0156	8-amino-7-oxononanoate synthase activity
B711_RS04265	COG1218	3'(2'),5'-bisphosphate nucleotidase
B711_RS04275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B711_RS04285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B711_RS04290	COG0799	negative regulation of ribosome biogenesis
B711_RS04310	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B711_RS04315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B711_RS04340	COG1181	Belongs to the D-alanine--D-alanine ligase family
B711_RS04340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B711_RS04345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B711_RS04350	COG0772	Belongs to the SEDS family
B711_RS04355	COG0791	NLP P60 protein
B711_RS04355	COG1388	LysM domain
B711_RS04360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B711_RS04365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B711_RS04370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B711_RS04380	COG0459	protein refolding
B711_RS04395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B711_RS04405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B711_RS04410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B711_RS04420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B711_RS04425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B711_RS04430	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B711_RS04445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B711_RS04450	COG1862	Preprotein translocase
B711_RS04455	COG2871	sodium ion transport
B711_RS04495	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B711_RS04505	COG1881	PFAM PEBP family protein
B711_RS04510	COG1115	amino acid carrier protein
B711_RS04525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B711_RS04530	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B711_RS04530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B711_RS04535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B711_RS04535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B711_RS04540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B711_RS04555	COG0772	Belongs to the SEDS family
B711_RS04570	COG1187	pseudouridine synthase activity
B711_RS04575	COG0588	phosphoglycerate mutase activity
B711_RS04605	COG1157	protein secretion by the type III secretion system
B711_RS04620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B711_RS04640	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B711_RS04645	COG1077	Cell shape determining protein MreB Mrl
B711_RS04650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B711_RS04665	COG0740	serine-type endopeptidase activity
B711_RS04670	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B711_RS04680	COG1160	GTP binding
B711_RS04690	COG0653	protein targeting
B711_RS04700	COG0688	phosphatidylethanolamine metabolic process
B711_RS04710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B711_RS04715	COG1114	Component of the transport system for branched-chain amino acids
B711_RS04720	COG1114	Component of the transport system for branched-chain amino acids
B711_RS04725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B711_RS04735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B711_RS04740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B711_RS04745	COG4669	(LipO)protein
B711_RS04770	COG4794	Type iii secretion
B711_RS04800	COG2165	general secretion pathway protein
B711_RS04805	COG1459	type II secretion system
B711_RS04830	COG0006	proline dipeptidase activity
B711_RS04860	COG0697	spore germination
B711_RS04865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B711_RS04870	COG1192	Involved in chromosome partitioning
B711_RS04885	COG0180	Tryptophanyl-tRNA synthetase
B711_RS04890	COG0556	nucleotide-excision repair
B711_RS04920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B711_RS04925	COG1053	succinate dehydrogenase
B711_RS04935	COG0084	hydrolase, TatD family'
B711_RS04945	COG0811	peptide transport
B711_RS04960	COG0823	Involved in the tonB-independent uptake of proteins
B711_RS04965	COG2885	chlorophyll binding
B711_RS04980	COG0450	alkyl hydroperoxide reductase
B711_RS04990	COG0459	protein refolding
B711_RS04995	COG3876	Protein conserved in bacteria
B711_RS05000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B711_RS05010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B711_RS05030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B711_RS05035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B711_RS05040	COG0762	integral membrane protein
B711_RS05060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B711_RS05070	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B711_RS05085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B711_RS05095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B711_RS05100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B711_RS05110	COG0268	Binds directly to 16S ribosomal RNA
B711_RS05120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B711_RS05135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain