locus-tag	class	description
CHPS25_RS00005	COG0113	porphobilinogen synthase activity
CHPS25_RS00010	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CHPS25_RS00020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CHPS25_RS00020	COG1747	RNA polymerase binding
CHPS25_RS00040	COG1074	ATP-dependent DNA helicase activity
CHPS25_RS00055	COG1054	Belongs to the UPF0176 family
CHPS25_RS00060	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CHPS25_RS00065	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CHPS25_RS00070	COG0728	peptidoglycan biosynthetic process
CHPS25_RS00125	COG1837	Belongs to the UPF0109 family
CHPS25_RS00130	COG0564	pseudouridine synthase activity
CHPS25_RS00155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CHPS25_RS00205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CHPS25_RS00210	COG0515	serine threonine protein kinase
CHPS25_RS00210	COG2815	serine threonine protein kinase
CHPS25_RS00225	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CHPS25_RS00230	COG3880	PFAM UvrB UvrC protein
CHPS25_RS00245	COG0233	cytoplasmic translational termination
CHPS25_RS00250	COG0528	UMP kinase activity
CHPS25_RS00255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CHPS25_RS00260	COG0052	Belongs to the universal ribosomal protein uS2 family
CHPS25_RS00285	COG0719	Fe-S assembly protein
CHPS25_RS00290	COG0396	ATPase activity
CHPS25_RS00295	COG0719	Fe-S assembly protein
CHPS25_RS00300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CHPS25_RS00315	COG1475	DNA binding
CHPS25_RS00320	COG4608	Belongs to the ABC transporter superfamily
CHPS25_RS00325	COG0444	Belongs to the ABC transporter superfamily
CHPS25_RS00330	COG1392	Phosphate transport regulator
CHPS25_RS00335	COG0306	phosphate transporter
CHPS25_RS00340	COG0126	phosphoglycerate kinase activity
CHPS25_RS00370	COG1686	Belongs to the peptidase S11 family
CHPS25_RS00400	COG0587	DNA-directed DNA polymerase activity
CHPS25_RS00415	COG0124	histidyl-tRNA synthetase
CHPS25_RS00420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CHPS25_RS00425	COG0545	Peptidyl-prolyl cis-trans isomerase
CHPS25_RS00435	COG3118	belongs to the thioredoxin family
CHPS25_RS00460	COG1607	acyl-coa hydrolase
CHPS25_RS00465	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CHPS25_RS00470	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CHPS25_RS00475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CHPS25_RS00480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CHPS25_RS00485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CHPS25_RS00495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CHPS25_RS00500	COG0088	Forms part of the polypeptide exit tunnel
CHPS25_RS00505	COG0089	rRNA binding
CHPS25_RS00510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CHPS25_RS00515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CHPS25_RS00520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CHPS25_RS00525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CHPS25_RS00530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CHPS25_RS00535	COG0255	Belongs to the universal ribosomal protein uL29 family
CHPS25_RS00540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CHPS25_RS00545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CHPS25_RS00550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CHPS25_RS00555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CHPS25_RS00560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CHPS25_RS00565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CHPS25_RS00570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CHPS25_RS00575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CHPS25_RS00580	COG0200	Binds to the 23S rRNA
CHPS25_RS00590	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CHPS25_RS00595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CHPS25_RS00600	COG0202	RNA polymerase activity
CHPS25_RS00605	COG0203	ribosomal protein L17
CHPS25_RS00610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CHPS25_RS00630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CHPS25_RS00635	COG0632	four-way junction helicase activity
CHPS25_RS00640	COG0105	UTP biosynthetic process
CHPS25_RS00650	COG0445	tRNA wobble uridine modification
CHPS25_RS00665	COG0305	Participates in initiation and elongation during chromosome replication
CHPS25_RS00675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CHPS25_RS00680	COG3202	ADP transmembrane transporter activity
CHPS25_RS00690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHPS25_RS00690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHPS25_RS00695	COG0237	dephospho-CoA kinase activity
CHPS25_RS00700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CHPS25_RS00710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CHPS25_RS00715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CHPS25_RS00725	COG0742	ribosomal rna small subunit methyltransferase
CHPS25_RS00735	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CHPS25_RS00765	COG0601	transmembrane transport
CHPS25_RS00770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHPS25_RS00775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CHPS25_RS00785	COG0072	phenylalanine-tRNA ligase activity
CHPS25_RS00785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHPS25_RS00790	COG1388	LysM domain
CHPS25_RS00795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CHPS25_RS00815	COG1381	Involved in DNA repair and RecF pathway recombination
CHPS25_RS00835	COG2204	response regulator
CHPS25_RS00845	COG4191	Histidine kinase
CHPS25_RS00865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CHPS25_RS00870	COG0101	tRNA pseudouridine synthase activity
CHPS25_RS00875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CHPS25_RS00880	COG1408	metallophosphoesterase
CHPS25_RS00905	COG0217	transcriptional regulatory protein
CHPS25_RS00915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CHPS25_RS00920	COG0018	arginyl-trna synthetase
CHPS25_RS00930	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CHPS25_RS00935	COG0575	Belongs to the CDS family
CHPS25_RS00940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CHPS25_RS00960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CHPS25_RS00960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CHPS25_RS00965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CHPS25_RS01005	COG0793	Belongs to the peptidase S41A family
CHPS25_RS01020	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CHPS25_RS01025	COG0049	tRNA binding
CHPS25_RS01030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CHPS25_RS01035	COG0051	transcription antitermination factor activity, RNA binding
CHPS25_RS01040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CHPS25_RS01045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CHPS25_RS01060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CHPS25_RS01065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CHPS25_RS01070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CHPS25_RS01075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CHPS25_RS01080	COG1121	(ABC) transporter
CHPS25_RS01085	COG0803	Belongs to the bacterial solute-binding protein 9 family
CHPS25_RS01095	COG0352	thiamine-phosphate diphosphorylase activity
CHPS25_RS01100	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CHPS25_RS01105	COG3210	domain, Protein
CHPS25_RS01110	COG4625	pathogenesis
CHPS25_RS01125	COG1115	amino acid carrier protein
CHPS25_RS01130	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CHPS25_RS01135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CHPS25_RS01140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CHPS25_RS01145	COG0307	riboflavin synthase, alpha
CHPS25_RS01160	COG1663	tetraacyldisaccharide 4'-kinase activity
CHPS25_RS01165	COG1301	dicarboxylic acid transport
CHPS25_RS01170	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHPS25_RS01175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CHPS25_RS01175	COG0517	IMP dehydrogenase activity
CHPS25_RS01205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CHPS25_RS01210	COG0740	serine-type endopeptidase activity
CHPS25_RS01215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CHPS25_RS01225	COG2226	methyltransferase
CHPS25_RS01235	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CHPS25_RS01245	COG4692	amylo-alpha-1,6-glucosidase activity
CHPS25_RS01250	COG1366	Belongs to the anti-sigma-factor antagonist family
CHPS25_RS01260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CHPS25_RS01280	COG2094	Belongs to the DNA glycosylase MPG family
CHPS25_RS01285	COG0557	exoribonuclease II activity
CHPS25_RS01290	COG0443	Heat shock 70 kDa protein
CHPS25_RS01295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CHPS25_RS01300	COG1420	regulation of RNA biosynthetic process
CHPS25_RS01305	COG0442	prolyl-tRNA aminoacylation
CHPS25_RS01320	COG1872	DUF167
CHPS25_RS01330	COG0436	Aminotransferase
CHPS25_RS01355	COG4286	Uncharacterised protein family (UPF0160)
CHPS25_RS01360	COG0537	adenosine 5'-monophosphoramidase activity
CHPS25_RS01385	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CHPS25_RS01395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHPS25_RS01405	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CHPS25_RS01405	COG0321	lipoyl(octanoyl) transferase activity
CHPS25_RS01410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CHPS25_RS01415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CHPS25_RS01425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CHPS25_RS01440	COG3210	domain, Protein
CHPS25_RS01445	COG3210	domain, Protein
CHPS25_RS01460	COG3210	domain, Protein
CHPS25_RS01470	COG3210	domain, Protein
CHPS25_RS01480	COG4625	pathogenesis
CHPS25_RS01485	COG4625	pathogenesis
CHPS25_RS01490	COG3210	domain, Protein
CHPS25_RS01495	COG3468	outer membrane autotransporter barrel domain protein
CHPS25_RS01500	COG3468	outer membrane autotransporter barrel domain protein
CHPS25_RS01510	COG4625	pathogenesis
CHPS25_RS01515	COG3468	outer membrane autotransporter barrel domain protein
CHPS25_RS01520	COG3210	domain, Protein
CHPS25_RS01525	COG3468	outer membrane autotransporter barrel domain protein
CHPS25_RS01530	COG3210	domain, Protein
CHPS25_RS01540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CHPS25_RS01545	COG0154	amidase activity
CHPS25_RS01550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CHPS25_RS01570	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CHPS25_RS01610	COG1331	Highly conserved protein containing a thioredoxin domain
CHPS25_RS01615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHPS25_RS01620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CHPS25_RS01625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CHPS25_RS01635	COG1722	exodeoxyribonuclease VII activity
CHPS25_RS01640	COG1570	exodeoxyribonuclease VII activity
CHPS25_RS01645	COG0149	triose-phosphate isomerase activity
CHPS25_RS01655	COG0242	peptide deformylase activity
CHPS25_RS01670	COG0424	maF-like protein
CHPS25_RS01675	COG0488	(ABC) transporter
CHPS25_RS01680	COG4974	Belongs to the 'phage' integrase family
CHPS25_RS01685	COG1234	tRNA 3'-trailer cleavage
CHPS25_RS01695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CHPS25_RS01700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CHPS25_RS01705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CHPS25_RS01710	COG0484	heat shock protein binding
CHPS25_RS01735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHPS25_RS01740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CHPS25_RS01745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CHPS25_RS01750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CHPS25_RS01755	COG1480	7TM receptor with intracellular HD hydrolase
CHPS25_RS01775	COG0181	hydroxymethylbilane synthase activity
CHPS25_RS01780	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CHPS25_RS01785	COG0571	ribonuclease III activity
CHPS25_RS01795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHPS25_RS01800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CHPS25_RS01810	COG0756	dUTP diphosphatase activity
CHPS25_RS01815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHPS25_RS01820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHPS25_RS01845	COG0482	sulfurtransferase activity
CHPS25_RS01850	COG0542	response to heat
CHPS25_RS01860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CHPS25_RS01870	COG0509	glycine decarboxylation via glycine cleavage system
CHPS25_RS01885	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CHPS25_RS01890	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CHPS25_RS01895	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CHPS25_RS01900	COG1805	sodium ion transport
CHPS25_RS01915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CHPS25_RS01930	COG0275	rRNA processing
CHPS25_RS01940	COG0768	penicillin binding
CHPS25_RS01950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CHPS25_RS01965	COG0776	regulation of translation
CHPS25_RS01975	COG0825	malonyl-CoA metabolic process
CHPS25_RS01980	COG1132	(ABC) transporter
CHPS25_RS01990	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CHPS25_RS02015	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CHPS25_RS02030	COG0564	pseudouridine synthase activity
CHPS25_RS02050	COG1266	CAAX protease self-immunity
CHPS25_RS02075	COG0631	protein serine/threonine phosphatase activity
CHPS25_RS02080	COG1104	cysteine desulfurase activity
CHPS25_RS02085	COG4535	Mg2 and Co2 transporter CorC
CHPS25_RS02090	COG4536	flavin adenine dinucleotide binding
CHPS25_RS02100	COG0717	Belongs to the dCTP deaminase family
CHPS25_RS02110	COG2255	four-way junction helicase activity
CHPS25_RS02115	COG2385	sporulation resulting in formation of a cellular spore
CHPS25_RS02135	COG0629	single-stranded DNA binding
CHPS25_RS02140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CHPS25_RS02185	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHPS25_RS02185	COG0567	Dehydrogenase, E1 component
CHPS25_RS02200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CHPS25_RS02220	COG0633	Ferredoxin
CHPS25_RS02230	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CHPS25_RS02235	COG1191	sigma factor activity
CHPS25_RS02245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CHPS25_RS02250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CHPS25_RS02255	COG0481	GTPase activity
CHPS25_RS02265	COG3202	ADP transmembrane transporter activity
CHPS25_RS02275	COG0803	Belongs to the bacterial solute-binding protein 9 family
CHPS25_RS02295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CHPS25_RS02300	COG0750	zinc metalloprotease
CHPS25_RS02315	COG0592	DNA-directed DNA polymerase activity
CHPS25_RS02320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CHPS25_RS02325	COG1477	protein flavinylation
CHPS25_RS02330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CHPS25_RS02355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CHPS25_RS02360	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CHPS25_RS02365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CHPS25_RS02385	COG4789	Type iii secretion
CHPS25_RS02390	COG4792	protein secretion
CHPS25_RS02395	COG0012	GTP binding
CHPS25_RS02400	COG0196	riboflavin kinase activity
CHPS25_RS02405	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CHPS25_RS02410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CHPS25_RS02415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CHPS25_RS02420	COG0195	Participates in both transcription termination and antitermination
CHPS25_RS02420	COG2251	uridine kinase activity
CHPS25_RS02425	COG2183	response to ionizing radiation
CHPS25_RS02425	COG0539	negative regulation of cytoplasmic translation
CHPS25_RS02435	COG0736	holo-[acyl-carrier-protein] synthase activity
CHPS25_RS02445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CHPS25_RS02450	COG0706	membrane insertase activity
CHPS25_RS02455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CHPS25_RS02465	COG0058	SHG alpha-glucan phosphorylase activity
CHPS25_RS02470	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHPS25_RS02475	COG0508	dehydrogenase complex catalyzes the overall conversion of
CHPS25_RS02475	COG0022	dehydrogenase e1 component
CHPS25_RS02480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CHPS25_RS02490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CHPS25_RS02500	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CHPS25_RS02505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CHPS25_RS02510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CHPS25_RS02515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CHPS25_RS02525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CHPS25_RS02550	COG0733	neurotransmitter:sodium symporter activity
CHPS25_RS02555	COG1823	symporter activity
CHPS25_RS02570	COG2239	Acts as a magnesium transporter
CHPS25_RS02580	COG0531	amino acid
CHPS25_RS02585	COG1830	Aldolase
CHPS25_RS02595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CHPS25_RS02600	COG2011	ABC-type metal ion transport system permease component
CHPS25_RS02605	COG1464	Belongs to the NlpA lipoprotein family
CHPS25_RS02620	COG0187	DNA topoisomerase II activity
CHPS25_RS02625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CHPS25_RS02630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CHPS25_RS02645	COG0009	L-threonylcarbamoyladenylate synthase
CHPS25_RS02680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHPS25_RS02695	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CHPS25_RS02705	COG0653	protein targeting
CHPS25_RS02735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CHPS25_RS02740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CHPS25_RS02750	COG1136	(ABC) transporter
CHPS25_RS02760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CHPS25_RS02765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CHPS25_RS02775	COG0563	adenylate kinase activity
CHPS25_RS02795	COG0363	glucosamine-6-phosphate deaminase activity
CHPS25_RS02800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CHPS25_RS02805	COG4166	transmembrane transport
CHPS25_RS02810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CHPS25_RS02815	COG1438	arginine binding
CHPS25_RS02825	COG1126	abc transporter atp-binding protein
CHPS25_RS02835	COG1295	ribonuclease BN
CHPS25_RS02850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CHPS25_RS02855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CHPS25_RS02860	COG0511	ligase activity, forming carbon-carbon bonds
CHPS25_RS02865	COG0439	Biotin carboxylase
CHPS25_RS02920	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CHPS25_RS02925	COG0519	Catalyzes the synthesis of GMP from XMP
CHPS25_RS02930	COG0516	GMP reductase activity
CHPS25_RS02930	COG0517	IMP dehydrogenase activity
CHPS25_RS02970	COG0343	queuine tRNA-ribosyltransferase activity
CHPS25_RS02990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CHPS25_RS03010	COG1116	anion transmembrane transporter activity
CHPS25_RS03035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CHPS25_RS03040	COG0504	CTP synthase activity
CHPS25_RS03045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CHPS25_RS03050	COG4166	transmembrane transport
CHPS25_RS03055	COG4166	transmembrane transport
CHPS25_RS03060	COG4166	transmembrane transport
CHPS25_RS03065	COG0601	transmembrane transport
CHPS25_RS03070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHPS25_RS03075	COG0444	Belongs to the ABC transporter superfamily
CHPS25_RS03080	COG4608	Belongs to the ABC transporter superfamily
CHPS25_RS03085	COG3012	SEC-C Motif Domain Protein
CHPS25_RS03090	COG0471	metal ion transport
CHPS25_RS03095	COG0205	6-phosphofructokinase activity
CHPS25_RS03125	COG0495	leucyl-tRNA aminoacylation
CHPS25_RS03145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CHPS25_RS03150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CHPS25_RS03150	COG0515	serine threonine protein kinase
CHPS25_RS03190	COG3468	outer membrane autotransporter barrel domain protein
CHPS25_RS03195	COG0542	response to heat
CHPS25_RS03205	COG1116	anion transmembrane transporter activity
CHPS25_RS03210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CHPS25_RS03215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CHPS25_RS03220	COG1678	Uncharacterized ACR, COG1678
CHPS25_RS03230	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CHPS25_RS03255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CHPS25_RS03260	COG1164	Oligoendopeptidase f
CHPS25_RS03265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CHPS25_RS03270	COG0459	protein refolding
CHPS25_RS03290	COG4285	Biotin-protein ligase, N terminal
CHPS25_RS03300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CHPS25_RS03305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHPS25_RS03315	COG0194	GDP metabolic process
CHPS25_RS03320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CHPS25_RS03325	COG0335	large ribosomal subunit rRNA binding
CHPS25_RS03330	COG0336	Belongs to the RNA methyltransferase TrmD family
CHPS25_RS03335	COG0228	four-way junction DNA binding
CHPS25_RS03340	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CHPS25_RS03350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CHPS25_RS03355	COG0254	rRNA binding
CHPS25_RS03370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CHPS25_RS03385	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CHPS25_RS03405	COG1294	oxidase, subunit
CHPS25_RS03410	COG1271	oxidase subunit
CHPS25_RS03415	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CHPS25_RS03435	COG0469	pyruvate kinase activity
CHPS25_RS03440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CHPS25_RS03445	COG0515	serine threonine protein kinase
CHPS25_RS03450	COG0525	valine-tRNA ligase activity
CHPS25_RS03465	COG1269	ATP hydrolysis coupled proton transport
CHPS25_RS03470	COG1394	ATPase activity, coupled to movement of substances
CHPS25_RS03475	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CHPS25_RS03480	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CHPS25_RS03490	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CHPS25_RS03505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CHPS25_RS03510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CHPS25_RS03515	COG0085	RNA polymerase activity
CHPS25_RS03520	COG0222	ribosome binding
CHPS25_RS03525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CHPS25_RS03530	COG0081	regulation of translation
CHPS25_RS03535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CHPS25_RS03540	COG0250	Participates in transcription elongation, termination and antitermination
CHPS25_RS03555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CHPS25_RS03565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CHPS25_RS03585	COG1268	BioY protein
CHPS25_RS03615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CHPS25_RS03620	COG0527	aspartate kinase activity
CHPS25_RS03630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CHPS25_RS03635	COG3186	Phenylalanine-4-hydroxylase
CHPS25_RS03650	COG1028	Short-chain dehydrogenase reductase Sdr
CHPS25_RS03655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CHPS25_RS03660	COG0156	8-amino-7-oxononanoate synthase activity
CHPS25_RS03665	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CHPS25_RS03670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CHPS25_RS03680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CHPS25_RS03685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CHPS25_RS03690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CHPS25_RS03695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CHPS25_RS03700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CHPS25_RS03700	COG0710	3-dehydroquinate dehydratase activity
CHPS25_RS03705	COG0546	phosphoglycolate phosphatase activity
CHPS25_RS03710	COG3659	wide pore channel activity
CHPS25_RS03715	COG1945	arginine decarboxylase activity
CHPS25_RS03720	COG0531	amino acid
CHPS25_RS03735	COG0039	L-malate dehydrogenase activity
CHPS25_RS03745	COG0166	Belongs to the GPI family
CHPS25_RS03750	COG4974	Belongs to the 'phage' integrase family
CHPS25_RS03790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CHPS25_RS03795	COG0793	Belongs to the peptidase S41A family
CHPS25_RS03805	COG0659	secondary active sulfate transmembrane transporter activity
CHPS25_RS03810	COG0114	fumarate hydratase activity
CHPS25_RS03815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CHPS25_RS03820	COG0563	adenylate kinase activity
CHPS25_RS03830	COG2095	MarC family integral membrane protein
CHPS25_RS03835	COG0024	Methionine aminopeptidase
CHPS25_RS03880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CHPS25_RS03885	COG1185	polyribonucleotide nucleotidyltransferase activity
CHPS25_RS03895	COG0037	tRNA processing
CHPS25_RS03920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CHPS25_RS03925	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CHPS25_RS03930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CHPS25_RS03935	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CHPS25_RS03940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CHPS25_RS03945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CHPS25_RS03950	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CHPS25_RS03960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CHPS25_RS03965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHPS25_RS03970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHPS25_RS03970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CHPS25_RS03975	COG1183	phosphatidylcholine synthase activity
CHPS25_RS03980	COG1322	Protein conserved in bacteria
CHPS25_RS03995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CHPS25_RS04000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CHPS25_RS04005	COG0045	succinate-CoA ligase (ADP-forming) activity
CHPS25_RS04010	COG0552	protein localization to endoplasmic reticulum
CHPS25_RS04015	COG0670	Belongs to the BI1 family
CHPS25_RS04020	COG0814	amino acid
CHPS25_RS04025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CHPS25_RS04030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHPS25_RS04035	COG0617	tRNA 3'-terminal CCA addition
CHPS25_RS04040	COG3952	Lipid A Biosynthesis
CHPS25_RS04040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CHPS25_RS04110	COG3210	domain, Protein
CHPS25_RS04110	COG4625	pathogenesis
CHPS25_RS04115	COG0416	fatty acid biosynthetic process
CHPS25_RS04120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CHPS25_RS04130	COG1530	ribonuclease E activity
CHPS25_RS04155	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CHPS25_RS04160	COG0359	binds to the 23S rRNA
CHPS25_RS04165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CHPS25_RS04170	COG0360	Binds together with S18 to 16S ribosomal RNA
CHPS25_RS04175	COG0193	aminoacyl-tRNA hydrolase activity
CHPS25_RS04180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CHPS25_RS04190	COG0297	glycogen (starch) synthase activity
CHPS25_RS04200	COG0752	glycyl-tRNA synthetase alpha subunit
CHPS25_RS04200	COG0751	glycine-tRNA ligase activity
CHPS25_RS04225	COG0358	DNA primase activity
CHPS25_RS04230	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CHPS25_RS04235	COG0322	excinuclease ABC activity
CHPS25_RS04250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CHPS25_RS04255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CHPS25_RS04260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CHPS25_RS04265	COG0594	ribonuclease P activity
CHPS25_RS04270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHPS25_RS04275	COG0215	cysteine-tRNA ligase activity
CHPS25_RS04280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CHPS25_RS04285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CHPS25_RS04295	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CHPS25_RS04300	COG0156	8-amino-7-oxononanoate synthase activity
CHPS25_RS04315	COG1218	3'(2'),5'-bisphosphate nucleotidase
CHPS25_RS04325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CHPS25_RS04335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CHPS25_RS04340	COG0799	negative regulation of ribosome biogenesis
CHPS25_RS04355	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CHPS25_RS04360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CHPS25_RS04385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CHPS25_RS04385	COG1181	Belongs to the D-alanine--D-alanine ligase family
CHPS25_RS04390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CHPS25_RS04395	COG0772	Belongs to the SEDS family
CHPS25_RS04400	COG1388	LysM domain
CHPS25_RS04400	COG0791	NLP P60 protein
CHPS25_RS04405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CHPS25_RS04410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CHPS25_RS04415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CHPS25_RS04425	COG0459	protein refolding
CHPS25_RS04440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CHPS25_RS04450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CHPS25_RS04455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CHPS25_RS04460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CHPS25_RS04465	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CHPS25_RS04470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CHPS25_RS04475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CHPS25_RS04490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHPS25_RS04495	COG1862	Preprotein translocase
CHPS25_RS04500	COG2871	sodium ion transport
CHPS25_RS04535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CHPS25_RS04545	COG1881	PFAM PEBP family protein
CHPS25_RS04550	COG1115	amino acid carrier protein
CHPS25_RS04565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CHPS25_RS04570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CHPS25_RS04570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CHPS25_RS04575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CHPS25_RS04575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CHPS25_RS04580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CHPS25_RS04595	COG0772	Belongs to the SEDS family
CHPS25_RS04610	COG1187	pseudouridine synthase activity
CHPS25_RS04615	COG0588	phosphoglycerate mutase activity
CHPS25_RS04640	COG1157	protein secretion by the type III secretion system
CHPS25_RS04655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CHPS25_RS04675	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CHPS25_RS04680	COG1077	Cell shape determining protein MreB Mrl
CHPS25_RS04685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CHPS25_RS04695	COG0544	peptidyl-prolyl cis-trans isomerase activity
CHPS25_RS04700	COG0740	serine-type endopeptidase activity
CHPS25_RS04705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CHPS25_RS04715	COG1160	GTP binding
CHPS25_RS04725	COG0653	protein targeting
CHPS25_RS04740	COG0688	phosphatidylethanolamine metabolic process
CHPS25_RS04745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CHPS25_RS04750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CHPS25_RS04755	COG1114	Component of the transport system for branched-chain amino acids
CHPS25_RS04760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CHPS25_RS04770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHPS25_RS04775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CHPS25_RS04780	COG4669	(LipO)protein
CHPS25_RS04800	COG4794	Type iii secretion
CHPS25_RS04830	COG2165	general secretion pathway protein
CHPS25_RS04835	COG1459	type II secretion system
CHPS25_RS04855	COG0006	proline dipeptidase activity
CHPS25_RS04860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CHPS25_RS04885	COG0697	spore germination
CHPS25_RS04890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CHPS25_RS04895	COG1192	Involved in chromosome partitioning
CHPS25_RS04910	COG0180	Tryptophanyl-tRNA synthetase
CHPS25_RS04915	COG0556	nucleotide-excision repair
CHPS25_RS04920	COG0148	phosphopyruvate hydratase activity
CHPS25_RS04945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CHPS25_RS04950	COG1053	succinate dehydrogenase
CHPS25_RS04960	COG0084	hydrolase, TatD family'
CHPS25_RS04970	COG0811	peptide transport
CHPS25_RS04985	COG0823	Involved in the tonB-independent uptake of proteins
CHPS25_RS04990	COG2885	chlorophyll binding
CHPS25_RS05005	COG0450	alkyl hydroperoxide reductase
CHPS25_RS05015	COG0459	protein refolding
CHPS25_RS05020	COG3876	Protein conserved in bacteria
CHPS25_RS05025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CHPS25_RS05035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CHPS25_RS05040	COG0210	DNA helicase
CHPS25_RS05055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CHPS25_RS05060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CHPS25_RS05065	COG0762	integral membrane protein
CHPS25_RS05085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CHPS25_RS05095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CHPS25_RS05110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CHPS25_RS05115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CHPS25_RS05115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CHPS25_RS05120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CHPS25_RS05125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CHPS25_RS05130	COG4372	Transposase
CHPS25_RS05135	COG0268	Binds directly to 16S ribosomal RNA
CHPS25_RS05145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CHPS25_RS05160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain