locus-tag	class	description
KW40_RS00055	COG1560	Kdo2-lipid A biosynthetic process
KW40_RS00065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KW40_RS00070	COG1271	oxidase subunit
KW40_RS00075	COG1294	oxidase, subunit
KW40_RS00080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KW40_RS00105	COG0681	Belongs to the peptidase S26 family
KW40_RS00130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KW40_RS00170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KW40_RS00255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KW40_RS00275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KW40_RS00285	COG0508	dehydrogenase complex catalyzes the overall conversion of
KW40_RS00285	COG0567	Dehydrogenase, E1 component
KW40_RS00290	COG0508	dehydrogenase complex catalyzes the overall conversion of
KW40_RS00310	COG0633	Ferredoxin
KW40_RS00320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KW40_RS00325	COG1191	sigma factor activity
KW40_RS00470	COG4789	Type iii secretion
KW40_RS00475	COG4792	protein secretion
KW40_RS00480	COG0012	GTP binding
KW40_RS00485	COG0196	riboflavin kinase activity
KW40_RS00505	COG0195	Participates in both transcription termination and antitermination
KW40_RS00540	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KW40_RS00550	COG0564	pseudouridine synthase activity
KW40_RS00575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KW40_RS00580	COG1164	Oligoendopeptidase f
KW40_RS00640	COG0439	Biotin carboxylase
KW40_RS00650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KW40_RS00665	COG0765	amino acid transport
KW40_RS00670	COG1126	abc transporter atp-binding protein
KW40_RS00715	COG4166	transmembrane transport
KW40_RS00725	COG3012	SEC-C Motif Domain Protein
KW40_RS00725	COG3318	Belongs to the UPF0149 family
KW40_RS00770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KW40_RS00790	COG1136	(ABC) transporter
KW40_RS00910	COG4166	transmembrane transport
KW40_RS00935	COG1116	anion transmembrane transporter activity
KW40_RS00970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KW40_RS00980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KW40_RS01015	COG2239	Acts as a magnesium transporter
KW40_RS01035	COG4166	transmembrane transport
KW40_RS01040	COG0601	transmembrane transport
KW40_RS01045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KW40_RS01050	COG0444	Belongs to the ABC transporter superfamily
KW40_RS01055	COG4608	Belongs to the ABC transporter superfamily
KW40_RS01065	COG0471	metal ion transport
KW40_RS01070	COG0205	6-phosphofructokinase activity
KW40_RS01135	COG0531	amino acid
KW40_RS01140	COG0037	tRNA processing
KW40_RS01150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KW40_RS01160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KW40_RS01225	COG0733	neurotransmitter:sodium symporter activity
KW40_RS01260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KW40_RS01275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KW40_RS01295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KW40_RS01300	COG0508	dehydrogenase complex catalyzes the overall conversion of
KW40_RS01300	COG0022	dehydrogenase e1 component
KW40_RS01305	COG0508	dehydrogenase complex catalyzes the overall conversion of
KW40_RS01340	COG1266	CAAX protease self-immunity
KW40_RS01350	COG4536	flavin adenine dinucleotide binding
KW40_RS01360	COG1104	cysteine desulfurase activity
KW40_RS01365	COG0631	protein serine/threonine phosphatase activity
KW40_RS01375	COG2176	DNA-directed DNA polymerase activity
KW40_RS01380	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
KW40_RS01390	COG1132	(ABC) transporter
KW40_RS01410	COG0860	N-Acetylmuramoyl-L-alanine amidase
KW40_RS01420	COG0768	penicillin binding
KW40_RS01490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KW40_RS01525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KW40_RS01535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KW40_RS01545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KW40_RS01705	COG2166	iron-sulfur cluster assembly
KW40_RS01775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KW40_RS01810	COG0022	dehydrogenase e1 component
KW40_RS01850	COG0488	(ABC) transporter
KW40_RS01890	COG1331	Highly conserved protein containing a thioredoxin domain
KW40_RS02015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KW40_RS02020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KW40_RS02020	COG0321	lipoyl(octanoyl) transferase activity
KW40_RS02030	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KW40_RS02030	COG1605	Chorismate mutase
KW40_RS02125	COG0508	dehydrogenase complex catalyzes the overall conversion of
KW40_RS02130	COG1301	dicarboxylic acid transport
KW40_RS02140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KW40_RS02160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KW40_RS02170	COG1115	amino acid carrier protein
KW40_RS02175	COG0617	tRNA 3'-terminal CCA addition
KW40_RS02265	COG1366	Belongs to the anti-sigma-factor antagonist family
KW40_RS02275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KW40_RS02320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KW40_RS02350	COG0793	Belongs to the peptidase S41A family
KW40_RS02360	COG1361	Conserved repeat domain
KW40_RS02385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KW40_RS02390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KW40_RS02390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KW40_RS02420	COG0204	Acyl-transferase
KW40_RS02420	COG0318	PFAM AMP-dependent synthetase and ligase
KW40_RS02445	COG1247	-acetyltransferase
KW40_RS02475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KW40_RS02565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KW40_RS02570	COG0601	transmembrane transport
KW40_RS02615	COG0742	ribosomal rna small subunit methyltransferase
KW40_RS02625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KW40_RS02635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KW40_RS02645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KW40_RS02645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KW40_RS02650	COG0616	signal peptide processing
KW40_RS02660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KW40_RS02675	COG0305	Participates in initiation and elongation during chromosome replication
KW40_RS02875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KW40_RS02900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KW40_RS02960	COG1686	Belongs to the peptidase S11 family
KW40_RS02980	COG1114	Component of the transport system for branched-chain amino acids
KW40_RS03005	COG4669	(LipO)protein
KW40_RS03030	COG4794	Type iii secretion
KW40_RS03065	COG1459	type II secretion system
KW40_RS03175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KW40_RS03195	COG0084	hydrolase, TatD family'
KW40_RS03205	COG0811	peptide transport
KW40_RS03225	COG2885	chlorophyll binding
KW40_RS03230	COG4641	Protein conserved in bacteria
KW40_RS03230	COG1388	LysM domain
KW40_RS03240	COG0450	alkyl hydroperoxide reductase
KW40_RS03250	COG0459	protein refolding
KW40_RS03255	COG3876	Protein conserved in bacteria
KW40_RS03275	COG0210	DNA helicase
KW40_RS03280	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KW40_RS03380	COG0142	geranyltranstransferase activity
KW40_RS03385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KW40_RS03455	COG2814	Major facilitator Superfamily
KW40_RS03465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KW40_RS03470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KW40_RS03495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KW40_RS03510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KW40_RS03550	COG0564	pseudouridine synthase activity
KW40_RS03625	COG0515	serine threonine protein kinase
KW40_RS03625	COG2815	serine threonine protein kinase
KW40_RS03690	COG0768	penicillin binding
KW40_RS03700	COG0719	Fe-S assembly protein
KW40_RS03705	COG0396	ATPase activity
KW40_RS03710	COG0719	Fe-S assembly protein
KW40_RS03725	COG4608	Belongs to the ABC transporter superfamily
KW40_RS03730	COG0444	Belongs to the ABC transporter superfamily
KW40_RS03765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KW40_RS03830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KW40_RS03835	COG1077	Cell shape determining protein MreB Mrl
KW40_RS03875	COG1157	protein secretion by the type III secretion system
KW40_RS03905	COG1187	pseudouridine synthase activity
KW40_RS03915	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
KW40_RS03915	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
KW40_RS03920	COG0772	Belongs to the SEDS family
KW40_RS03965	COG1115	amino acid carrier protein
KW40_RS03980	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KW40_RS04040	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KW40_RS04045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KW40_RS04055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KW40_RS04085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KW40_RS04110	COG0459	protein refolding
KW40_RS04120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KW40_RS04140	COG0772	Belongs to the SEDS family
KW40_RS04155	COG1837	Belongs to the UPF0109 family
KW40_RS04165	COG1366	Belongs to the anti-sigma-factor antagonist family
KW40_RS04175	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KW40_RS04185	COG0799	negative regulation of ribosome biogenesis
KW40_RS04190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KW40_RS04215	COG1218	3'(2'),5'-bisphosphate nucleotidase
KW40_RS04230	COG0156	8-amino-7-oxononanoate synthase activity
KW40_RS04245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KW40_RS04260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KW40_RS04390	COG1025	Belongs to the peptidase M16 family
KW40_RS04455	COG0814	amino acid
KW40_RS04460	COG0814	amino acid
KW40_RS04470	COG0552	protein localization to endoplasmic reticulum
KW40_RS04480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KW40_RS04520	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KW40_RS04650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KW40_RS04660	COG0659	secondary active sulfate transmembrane transporter activity