locus-tag	class	description
A7249_RS00055	COG1560	Kdo2-lipid A biosynthetic process
A7249_RS00065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A7249_RS00070	COG1271	oxidase subunit
A7249_RS00075	COG1294	oxidase, subunit
A7249_RS00080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A7249_RS00105	COG0681	Belongs to the peptidase S26 family
A7249_RS00130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A7249_RS00170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7249_RS00255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A7249_RS00275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7249_RS00290	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7249_RS00320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A7249_RS00325	COG1191	sigma factor activity
A7249_RS00345	COG3202	ADP transmembrane transporter activity
A7249_RS00470	COG4789	Type iii secretion
A7249_RS00475	COG4792	protein secretion
A7249_RS00480	COG0012	GTP binding
A7249_RS00485	COG0196	riboflavin kinase activity
A7249_RS00505	COG0195	Participates in both transcription termination and antitermination
A7249_RS00540	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A7249_RS00555	COG0564	pseudouridine synthase activity
A7249_RS00580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A7249_RS00585	COG1164	Oligoendopeptidase f
A7249_RS00645	COG0439	Biotin carboxylase
A7249_RS00655	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A7249_RS00670	COG0765	amino acid transport
A7249_RS00675	COG1126	abc transporter atp-binding protein
A7249_RS00720	COG4166	transmembrane transport
A7249_RS00730	COG3012	SEC-C Motif Domain Protein
A7249_RS00730	COG3318	Belongs to the UPF0149 family
A7249_RS00775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A7249_RS00795	COG1136	(ABC) transporter
A7249_RS00935	COG4166	transmembrane transport
A7249_RS00960	COG1116	anion transmembrane transporter activity
A7249_RS00995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A7249_RS01005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7249_RS01040	COG2239	Acts as a magnesium transporter
A7249_RS01060	COG4166	transmembrane transport
A7249_RS01065	COG0601	transmembrane transport
A7249_RS01070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7249_RS01075	COG0444	Belongs to the ABC transporter superfamily
A7249_RS01080	COG4608	Belongs to the ABC transporter superfamily
A7249_RS01090	COG0471	metal ion transport
A7249_RS01095	COG0205	6-phosphofructokinase activity
A7249_RS01160	COG0531	amino acid
A7249_RS01165	COG0037	tRNA processing
A7249_RS01175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A7249_RS01185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A7249_RS01250	COG0733	neurotransmitter:sodium symporter activity
A7249_RS01285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A7249_RS01300	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A7249_RS01320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A7249_RS01325	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7249_RS01325	COG0022	dehydrogenase e1 component
A7249_RS01330	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7249_RS01365	COG1266	CAAX protease self-immunity
A7249_RS01375	COG4536	flavin adenine dinucleotide binding
A7249_RS01385	COG1104	cysteine desulfurase activity
A7249_RS01390	COG0631	protein serine/threonine phosphatase activity
A7249_RS01400	COG2176	DNA-directed DNA polymerase activity
A7249_RS01405	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A7249_RS01415	COG1132	(ABC) transporter
A7249_RS01435	COG0860	N-Acetylmuramoyl-L-alanine amidase
A7249_RS01445	COG0768	penicillin binding
A7249_RS01515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A7249_RS01550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A7249_RS01560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A7249_RS01570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A7249_RS01730	COG2166	iron-sulfur cluster assembly
A7249_RS01795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A7249_RS01830	COG0022	dehydrogenase e1 component
A7249_RS01870	COG0488	(ABC) transporter
A7249_RS01910	COG1331	Highly conserved protein containing a thioredoxin domain
A7249_RS02035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A7249_RS02040	COG0321	lipoyl(octanoyl) transferase activity
A7249_RS02040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7249_RS02050	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A7249_RS02050	COG1605	Chorismate mutase
A7249_RS02145	COG0508	dehydrogenase complex catalyzes the overall conversion of
A7249_RS02150	COG1301	dicarboxylic acid transport
A7249_RS02180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A7249_RS02190	COG1115	amino acid carrier protein
A7249_RS02195	COG0617	tRNA 3'-terminal CCA addition
A7249_RS02290	COG1366	Belongs to the anti-sigma-factor antagonist family
A7249_RS02300	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A7249_RS02345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A7249_RS02375	COG0793	Belongs to the peptidase S41A family
A7249_RS02410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A7249_RS02415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7249_RS02415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A7249_RS02450	COG0204	Acyl-transferase
A7249_RS02450	COG0318	PFAM AMP-dependent synthetase and ligase
A7249_RS02505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A7249_RS02595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A7249_RS02600	COG0601	transmembrane transport
A7249_RS02645	COG0742	ribosomal rna small subunit methyltransferase
A7249_RS02655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A7249_RS02665	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A7249_RS02675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7249_RS02675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A7249_RS02680	COG0616	signal peptide processing
A7249_RS02690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A7249_RS02705	COG0305	Participates in initiation and elongation during chromosome replication
A7249_RS02905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A7249_RS02930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A7249_RS02985	COG1686	Belongs to the peptidase S11 family
A7249_RS03030	COG4669	(LipO)protein
A7249_RS03055	COG4794	Type iii secretion
A7249_RS03060	COG4791	protein targeting
A7249_RS03090	COG1459	type II secretion system
A7249_RS03200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A7249_RS03205	COG1053	succinate dehydrogenase
A7249_RS03210	COG1053	succinate dehydrogenase
A7249_RS03225	COG0084	hydrolase, TatD family'
A7249_RS03235	COG0811	peptide transport
A7249_RS03255	COG2885	chlorophyll binding
A7249_RS03260	COG1388	LysM domain
A7249_RS03260	COG4641	Protein conserved in bacteria
A7249_RS03270	COG0450	alkyl hydroperoxide reductase
A7249_RS03280	COG0459	protein refolding
A7249_RS03285	COG3876	Protein conserved in bacteria
A7249_RS03305	COG0210	DNA helicase
A7249_RS03310	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A7249_RS03405	COG0142	geranyltranstransferase activity
A7249_RS03410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A7249_RS03480	COG2814	Major facilitator Superfamily
A7249_RS03490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A7249_RS03495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A7249_RS03520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A7249_RS03540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A7249_RS03580	COG0564	pseudouridine synthase activity
A7249_RS03655	COG2815	serine threonine protein kinase
A7249_RS03655	COG0515	serine threonine protein kinase
A7249_RS03720	COG0768	penicillin binding
A7249_RS03730	COG0719	Fe-S assembly protein
A7249_RS03735	COG0396	ATPase activity
A7249_RS03740	COG0719	Fe-S assembly protein
A7249_RS03755	COG4608	Belongs to the ABC transporter superfamily
A7249_RS03760	COG0444	Belongs to the ABC transporter superfamily
A7249_RS03795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A7249_RS03860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A7249_RS03865	COG1077	Cell shape determining protein MreB Mrl
A7249_RS03895	COG4284	Utp--glucose-1-phosphate uridylyltransferase
A7249_RS03935	COG1187	pseudouridine synthase activity
A7249_RS03945	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A7249_RS03945	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A7249_RS03950	COG0772	Belongs to the SEDS family
A7249_RS03995	COG1115	amino acid carrier protein
A7249_RS04010	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A7249_RS04070	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A7249_RS04075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A7249_RS04085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A7249_RS04115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A7249_RS04140	COG0459	protein refolding
A7249_RS04150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A7249_RS04170	COG0772	Belongs to the SEDS family
A7249_RS04185	COG1837	Belongs to the UPF0109 family
A7249_RS04195	COG1366	Belongs to the anti-sigma-factor antagonist family
A7249_RS04205	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A7249_RS04215	COG0799	negative regulation of ribosome biogenesis
A7249_RS04220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A7249_RS04245	COG1218	3'(2'),5'-bisphosphate nucleotidase
A7249_RS04260	COG0156	8-amino-7-oxononanoate synthase activity
A7249_RS04275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7249_RS04290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A7249_RS04420	COG1025	Belongs to the peptidase M16 family
A7249_RS04480	COG0814	amino acid
A7249_RS04485	COG0814	amino acid
A7249_RS04495	COG0552	protein localization to endoplasmic reticulum
A7249_RS04505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A7249_RS04545	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A7249_RS04620	COG0590	tRNA wobble adenosine to inosine editing
A7249_RS04685	COG0659	secondary active sulfate transmembrane transporter activity