locus-tag	class	description
DCS63711_RS00055	COG1560	Kdo2-lipid A biosynthetic process
DCS63711_RS00065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DCS63711_RS00070	COG1271	oxidase subunit
DCS63711_RS00075	COG1294	oxidase, subunit
DCS63711_RS00080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DCS63711_RS00105	COG0681	Belongs to the peptidase S26 family
DCS63711_RS00130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DCS63711_RS00170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DCS63711_RS00255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DCS63711_RS00275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DCS63711_RS00285	COG0567	Dehydrogenase, E1 component
DCS63711_RS00285	COG0508	dehydrogenase complex catalyzes the overall conversion of
DCS63711_RS00290	COG0508	dehydrogenase complex catalyzes the overall conversion of
DCS63711_RS00310	COG0633	Ferredoxin
DCS63711_RS00320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DCS63711_RS00325	COG1191	sigma factor activity
DCS63711_RS00470	COG4789	Type iii secretion
DCS63711_RS00475	COG4792	protein secretion
DCS63711_RS00480	COG0012	GTP binding
DCS63711_RS00485	COG0196	riboflavin kinase activity
DCS63711_RS00505	COG0195	Participates in both transcription termination and antitermination
DCS63711_RS00540	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DCS63711_RS00550	COG0564	pseudouridine synthase activity
DCS63711_RS00580	COG1164	Oligoendopeptidase f
DCS63711_RS00640	COG0439	Biotin carboxylase
DCS63711_RS00650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DCS63711_RS00665	COG0765	amino acid transport
DCS63711_RS00670	COG1126	abc transporter atp-binding protein
DCS63711_RS00715	COG4166	transmembrane transport
DCS63711_RS00725	COG3012	SEC-C Motif Domain Protein
DCS63711_RS00725	COG3318	Belongs to the UPF0149 family
DCS63711_RS00770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DCS63711_RS00790	COG1136	(ABC) transporter
DCS63711_RS00910	COG4166	transmembrane transport
DCS63711_RS00935	COG1116	anion transmembrane transporter activity
DCS63711_RS00970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DCS63711_RS00980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DCS63711_RS01015	COG2239	Acts as a magnesium transporter
DCS63711_RS01035	COG4166	transmembrane transport
DCS63711_RS01040	COG0601	transmembrane transport
DCS63711_RS01045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DCS63711_RS01050	COG0444	Belongs to the ABC transporter superfamily
DCS63711_RS01055	COG4608	Belongs to the ABC transporter superfamily
DCS63711_RS01065	COG0471	metal ion transport
DCS63711_RS01070	COG0205	6-phosphofructokinase activity
DCS63711_RS01135	COG0531	amino acid
DCS63711_RS01140	COG0037	tRNA processing
DCS63711_RS01150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DCS63711_RS01160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DCS63711_RS01225	COG0733	neurotransmitter:sodium symporter activity
DCS63711_RS01260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DCS63711_RS01275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DCS63711_RS01295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DCS63711_RS01300	COG0022	dehydrogenase e1 component
DCS63711_RS01300	COG0508	dehydrogenase complex catalyzes the overall conversion of
DCS63711_RS01305	COG0508	dehydrogenase complex catalyzes the overall conversion of
DCS63711_RS01340	COG1266	CAAX protease self-immunity
DCS63711_RS01350	COG4536	flavin adenine dinucleotide binding
DCS63711_RS01360	COG1104	cysteine desulfurase activity
DCS63711_RS01365	COG0631	protein serine/threonine phosphatase activity
DCS63711_RS01375	COG2176	DNA-directed DNA polymerase activity
DCS63711_RS01380	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DCS63711_RS01390	COG1132	(ABC) transporter
DCS63711_RS01410	COG0860	N-Acetylmuramoyl-L-alanine amidase
DCS63711_RS01420	COG0768	penicillin binding
DCS63711_RS01490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DCS63711_RS01525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DCS63711_RS01535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DCS63711_RS01545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DCS63711_RS01705	COG2166	iron-sulfur cluster assembly
DCS63711_RS01770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DCS63711_RS01805	COG0022	dehydrogenase e1 component
DCS63711_RS01845	COG0488	(ABC) transporter
DCS63711_RS01885	COG1331	Highly conserved protein containing a thioredoxin domain
DCS63711_RS02010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DCS63711_RS02015	COG0321	lipoyl(octanoyl) transferase activity
DCS63711_RS02015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DCS63711_RS02025	COG1605	Chorismate mutase
DCS63711_RS02025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DCS63711_RS02120	COG0508	dehydrogenase complex catalyzes the overall conversion of
DCS63711_RS02125	COG1301	dicarboxylic acid transport
DCS63711_RS02155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DCS63711_RS02165	COG1115	amino acid carrier protein
DCS63711_RS02170	COG0617	tRNA 3'-terminal CCA addition
DCS63711_RS02260	COG1366	Belongs to the anti-sigma-factor antagonist family
DCS63711_RS02270	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DCS63711_RS02315	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DCS63711_RS02345	COG0793	Belongs to the peptidase S41A family
DCS63711_RS02380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DCS63711_RS02385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DCS63711_RS02385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DCS63711_RS02415	COG0318	PFAM AMP-dependent synthetase and ligase
DCS63711_RS02415	COG0204	Acyl-transferase
DCS63711_RS02440	COG1247	-acetyltransferase
DCS63711_RS02470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DCS63711_RS02560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DCS63711_RS02565	COG0601	transmembrane transport
DCS63711_RS02610	COG0742	ribosomal rna small subunit methyltransferase
DCS63711_RS02620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DCS63711_RS02630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DCS63711_RS02640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DCS63711_RS02640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DCS63711_RS02645	COG0616	signal peptide processing
DCS63711_RS02655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DCS63711_RS02670	COG0305	Participates in initiation and elongation during chromosome replication
DCS63711_RS02870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DCS63711_RS02895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DCS63711_RS02950	COG1686	Belongs to the peptidase S11 family
DCS63711_RS03000	COG4669	(LipO)protein
DCS63711_RS03025	COG4794	Type iii secretion
DCS63711_RS03030	COG4791	protein targeting
DCS63711_RS03060	COG1459	type II secretion system
DCS63711_RS03170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DCS63711_RS03190	COG0084	hydrolase, TatD family'
DCS63711_RS03200	COG0811	peptide transport
DCS63711_RS03220	COG2885	chlorophyll binding
DCS63711_RS03225	COG4641	Protein conserved in bacteria
DCS63711_RS03225	COG1388	LysM domain
DCS63711_RS03235	COG0450	alkyl hydroperoxide reductase
DCS63711_RS03245	COG0459	protein refolding
DCS63711_RS03250	COG3876	Protein conserved in bacteria
DCS63711_RS03270	COG0210	DNA helicase
DCS63711_RS03275	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DCS63711_RS03370	COG0142	geranyltranstransferase activity
DCS63711_RS03375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DCS63711_RS03445	COG2814	Major facilitator Superfamily
DCS63711_RS03455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DCS63711_RS03460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DCS63711_RS03485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DCS63711_RS03505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DCS63711_RS03545	COG0564	pseudouridine synthase activity
DCS63711_RS03620	COG2815	serine threonine protein kinase
DCS63711_RS03620	COG0515	serine threonine protein kinase
DCS63711_RS03685	COG0768	penicillin binding
DCS63711_RS03695	COG0719	Fe-S assembly protein
DCS63711_RS03700	COG0396	ATPase activity
DCS63711_RS03705	COG0719	Fe-S assembly protein
DCS63711_RS03720	COG4608	Belongs to the ABC transporter superfamily
DCS63711_RS03725	COG0444	Belongs to the ABC transporter superfamily
DCS63711_RS03760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DCS63711_RS03825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DCS63711_RS03830	COG1077	Cell shape determining protein MreB Mrl
DCS63711_RS03860	COG4284	Utp--glucose-1-phosphate uridylyltransferase
DCS63711_RS03900	COG1187	pseudouridine synthase activity
DCS63711_RS03910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DCS63711_RS03910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DCS63711_RS03915	COG0772	Belongs to the SEDS family
DCS63711_RS03960	COG1115	amino acid carrier protein
DCS63711_RS03975	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DCS63711_RS04035	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DCS63711_RS04040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DCS63711_RS04050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DCS63711_RS04080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DCS63711_RS04105	COG0459	protein refolding
DCS63711_RS04115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DCS63711_RS04135	COG0772	Belongs to the SEDS family
DCS63711_RS04150	COG1837	Belongs to the UPF0109 family
DCS63711_RS04160	COG1366	Belongs to the anti-sigma-factor antagonist family
DCS63711_RS04170	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DCS63711_RS04180	COG0799	negative regulation of ribosome biogenesis
DCS63711_RS04185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DCS63711_RS04205	COG1218	3'(2'),5'-bisphosphate nucleotidase
DCS63711_RS04220	COG0156	8-amino-7-oxononanoate synthase activity
DCS63711_RS04235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DCS63711_RS04250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DCS63711_RS04385	COG1025	Belongs to the peptidase M16 family
DCS63711_RS04445	COG0814	amino acid
DCS63711_RS04450	COG0814	amino acid
DCS63711_RS04460	COG0552	protein localization to endoplasmic reticulum
DCS63711_RS04470	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DCS63711_RS04510	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DCS63711_RS04640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DCS63711_RS04650	COG0659	secondary active sulfate transmembrane transporter activity