locus-tag	class	description
ECS102511_RS00055	COG1560	Kdo2-lipid A biosynthetic process
ECS102511_RS00065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ECS102511_RS00070	COG1271	oxidase subunit
ECS102511_RS00075	COG1294	oxidase, subunit
ECS102511_RS00080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ECS102511_RS00105	COG0681	Belongs to the peptidase S26 family
ECS102511_RS00130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ECS102511_RS00170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ECS102511_RS00255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ECS102511_RS00275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ECS102511_RS00290	COG0508	dehydrogenase complex catalyzes the overall conversion of
ECS102511_RS00310	COG0633	Ferredoxin
ECS102511_RS00320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ECS102511_RS00325	COG1191	sigma factor activity
ECS102511_RS00470	COG4789	Type iii secretion
ECS102511_RS00475	COG4792	protein secretion
ECS102511_RS00480	COG0012	GTP binding
ECS102511_RS00485	COG0196	riboflavin kinase activity
ECS102511_RS00505	COG0195	Participates in both transcription termination and antitermination
ECS102511_RS00540	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ECS102511_RS00550	COG0564	pseudouridine synthase activity
ECS102511_RS00575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ECS102511_RS00580	COG1164	Oligoendopeptidase f
ECS102511_RS00640	COG0439	Biotin carboxylase
ECS102511_RS00650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ECS102511_RS00665	COG0765	amino acid transport
ECS102511_RS00670	COG1126	abc transporter atp-binding protein
ECS102511_RS00715	COG4166	transmembrane transport
ECS102511_RS00725	COG3012	SEC-C Motif Domain Protein
ECS102511_RS00725	COG3318	Belongs to the UPF0149 family
ECS102511_RS00770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ECS102511_RS00790	COG1136	(ABC) transporter
ECS102511_RS00905	COG4166	transmembrane transport
ECS102511_RS00930	COG1116	anion transmembrane transporter activity
ECS102511_RS00965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ECS102511_RS00975	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ECS102511_RS01010	COG2239	Acts as a magnesium transporter
ECS102511_RS01030	COG4166	transmembrane transport
ECS102511_RS01035	COG0601	transmembrane transport
ECS102511_RS01040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ECS102511_RS01045	COG0444	Belongs to the ABC transporter superfamily
ECS102511_RS01050	COG4608	Belongs to the ABC transporter superfamily
ECS102511_RS01060	COG0471	metal ion transport
ECS102511_RS01065	COG0205	6-phosphofructokinase activity
ECS102511_RS01130	COG0531	amino acid
ECS102511_RS01135	COG0037	tRNA processing
ECS102511_RS01145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ECS102511_RS01155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ECS102511_RS01220	COG0733	neurotransmitter:sodium symporter activity
ECS102511_RS01255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ECS102511_RS01270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ECS102511_RS01290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ECS102511_RS01295	COG0022	dehydrogenase e1 component
ECS102511_RS01295	COG0508	dehydrogenase complex catalyzes the overall conversion of
ECS102511_RS01300	COG0508	dehydrogenase complex catalyzes the overall conversion of
ECS102511_RS01335	COG1266	CAAX protease self-immunity
ECS102511_RS01345	COG4536	flavin adenine dinucleotide binding
ECS102511_RS01355	COG1104	cysteine desulfurase activity
ECS102511_RS01360	COG0631	protein serine/threonine phosphatase activity
ECS102511_RS01370	COG2176	DNA-directed DNA polymerase activity
ECS102511_RS01375	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ECS102511_RS01385	COG1132	(ABC) transporter
ECS102511_RS01405	COG0860	N-Acetylmuramoyl-L-alanine amidase
ECS102511_RS01415	COG0768	penicillin binding
ECS102511_RS01485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ECS102511_RS01520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ECS102511_RS01530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ECS102511_RS01540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ECS102511_RS01705	COG2166	iron-sulfur cluster assembly
ECS102511_RS01775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ECS102511_RS01810	COG0022	dehydrogenase e1 component
ECS102511_RS01850	COG0488	(ABC) transporter
ECS102511_RS01890	COG1331	Highly conserved protein containing a thioredoxin domain
ECS102511_RS02015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ECS102511_RS02020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ECS102511_RS02020	COG0321	lipoyl(octanoyl) transferase activity
ECS102511_RS02030	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ECS102511_RS02030	COG1605	Chorismate mutase
ECS102511_RS02125	COG0508	dehydrogenase complex catalyzes the overall conversion of
ECS102511_RS02130	COG1301	dicarboxylic acid transport
ECS102511_RS02140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ECS102511_RS02160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ECS102511_RS02170	COG1115	amino acid carrier protein
ECS102511_RS02175	COG0617	tRNA 3'-terminal CCA addition
ECS102511_RS02265	COG1366	Belongs to the anti-sigma-factor antagonist family
ECS102511_RS02275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ECS102511_RS02320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ECS102511_RS02350	COG0793	Belongs to the peptidase S41A family
ECS102511_RS02360	COG1361	Conserved repeat domain
ECS102511_RS02385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ECS102511_RS02390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ECS102511_RS02390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ECS102511_RS02420	COG0204	Acyl-transferase
ECS102511_RS02420	COG0318	PFAM AMP-dependent synthetase and ligase
ECS102511_RS02445	COG1247	-acetyltransferase
ECS102511_RS02475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ECS102511_RS02565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ECS102511_RS02570	COG0601	transmembrane transport
ECS102511_RS02615	COG0742	ribosomal rna small subunit methyltransferase
ECS102511_RS02625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ECS102511_RS02635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ECS102511_RS02645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ECS102511_RS02645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ECS102511_RS02650	COG0616	signal peptide processing
ECS102511_RS02660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ECS102511_RS02675	COG0305	Participates in initiation and elongation during chromosome replication
ECS102511_RS02875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ECS102511_RS02900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ECS102511_RS02955	COG1686	Belongs to the peptidase S11 family
ECS102511_RS03000	COG4669	(LipO)protein
ECS102511_RS03025	COG4794	Type iii secretion
ECS102511_RS03060	COG1459	type II secretion system
ECS102511_RS03170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ECS102511_RS03190	COG0084	hydrolase, TatD family'
ECS102511_RS03200	COG0811	peptide transport
ECS102511_RS03220	COG2885	chlorophyll binding
ECS102511_RS03225	COG4641	Protein conserved in bacteria
ECS102511_RS03225	COG1388	LysM domain
ECS102511_RS03235	COG0450	alkyl hydroperoxide reductase
ECS102511_RS03245	COG0459	protein refolding
ECS102511_RS03250	COG3876	Protein conserved in bacteria
ECS102511_RS03270	COG0210	DNA helicase
ECS102511_RS03275	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ECS102511_RS03370	COG0142	geranyltranstransferase activity
ECS102511_RS03375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ECS102511_RS03445	COG2814	Major facilitator Superfamily
ECS102511_RS03455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ECS102511_RS03460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ECS102511_RS03485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ECS102511_RS03500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ECS102511_RS03540	COG0564	pseudouridine synthase activity
ECS102511_RS03610	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ECS102511_RS03615	COG0515	serine threonine protein kinase
ECS102511_RS03615	COG2815	serine threonine protein kinase
ECS102511_RS03680	COG0768	penicillin binding
ECS102511_RS03690	COG0719	Fe-S assembly protein
ECS102511_RS03695	COG0396	ATPase activity
ECS102511_RS03700	COG0719	Fe-S assembly protein
ECS102511_RS03715	COG4608	Belongs to the ABC transporter superfamily
ECS102511_RS03720	COG0444	Belongs to the ABC transporter superfamily
ECS102511_RS03755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ECS102511_RS03820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ECS102511_RS03825	COG1077	Cell shape determining protein MreB Mrl
ECS102511_RS03855	COG4284	Utp--glucose-1-phosphate uridylyltransferase
ECS102511_RS03865	COG1157	protein secretion by the type III secretion system
ECS102511_RS03895	COG1187	pseudouridine synthase activity
ECS102511_RS03905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ECS102511_RS03905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ECS102511_RS03910	COG0772	Belongs to the SEDS family
ECS102511_RS03955	COG1115	amino acid carrier protein
ECS102511_RS03970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ECS102511_RS04030	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ECS102511_RS04035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ECS102511_RS04045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ECS102511_RS04075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ECS102511_RS04100	COG0459	protein refolding
ECS102511_RS04110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ECS102511_RS04130	COG0772	Belongs to the SEDS family
ECS102511_RS04145	COG1837	Belongs to the UPF0109 family
ECS102511_RS04155	COG1366	Belongs to the anti-sigma-factor antagonist family
ECS102511_RS04165	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ECS102511_RS04175	COG0799	negative regulation of ribosome biogenesis
ECS102511_RS04180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ECS102511_RS04205	COG1218	3'(2'),5'-bisphosphate nucleotidase
ECS102511_RS04220	COG0156	8-amino-7-oxononanoate synthase activity
ECS102511_RS04235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ECS102511_RS04250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ECS102511_RS04385	COG1025	Belongs to the peptidase M16 family
ECS102511_RS04450	COG0814	amino acid
ECS102511_RS04455	COG0814	amino acid
ECS102511_RS04465	COG0552	protein localization to endoplasmic reticulum
ECS102511_RS04475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ECS102511_RS04515	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ECS102511_RS04645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ECS102511_RS04655	COG0659	secondary active sulfate transmembrane transporter activity