locus-tag	class	description
L2bCS78408_RS00060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L2bCS78408_RS00065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2bCS78408_RS00090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2bCS78408_RS00105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2bCS78408_RS00145	COG0564	pseudouridine synthase activity
L2bCS78408_RS00220	COG2815	serine threonine protein kinase
L2bCS78408_RS00220	COG0515	serine threonine protein kinase
L2bCS78408_RS00285	COG0768	penicillin binding
L2bCS78408_RS00295	COG0719	Fe-S assembly protein
L2bCS78408_RS00300	COG0396	ATPase activity
L2bCS78408_RS00305	COG0719	Fe-S assembly protein
L2bCS78408_RS00320	COG4608	Belongs to the ABC transporter superfamily
L2bCS78408_RS00325	COG0444	Belongs to the ABC transporter superfamily
L2bCS78408_RS00360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2bCS78408_RS00425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2bCS78408_RS00430	COG1077	Cell shape determining protein MreB Mrl
L2bCS78408_RS00460	COG4284	Utp--glucose-1-phosphate uridylyltransferase
L2bCS78408_RS00500	COG1187	pseudouridine synthase activity
L2bCS78408_RS00510	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L2bCS78408_RS00510	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L2bCS78408_RS00515	COG0772	Belongs to the SEDS family
L2bCS78408_RS00560	COG1115	amino acid carrier protein
L2bCS78408_RS00575	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L2bCS78408_RS00635	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L2bCS78408_RS00640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2bCS78408_RS00650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2bCS78408_RS00680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2bCS78408_RS00715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2bCS78408_RS00735	COG0772	Belongs to the SEDS family
L2bCS78408_RS00750	COG1837	Belongs to the UPF0109 family
L2bCS78408_RS00760	COG1366	Belongs to the anti-sigma-factor antagonist family
L2bCS78408_RS00770	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L2bCS78408_RS00780	COG0799	negative regulation of ribosome biogenesis
L2bCS78408_RS00785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2bCS78408_RS00805	COG1218	3'(2'),5'-bisphosphate nucleotidase
L2bCS78408_RS00820	COG0156	8-amino-7-oxononanoate synthase activity
L2bCS78408_RS00835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2bCS78408_RS00850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2bCS78408_RS00980	COG1025	Belongs to the peptidase M16 family
L2bCS78408_RS01045	COG0814	amino acid
L2bCS78408_RS01050	COG0814	amino acid
L2bCS78408_RS01060	COG0552	protein localization to endoplasmic reticulum
L2bCS78408_RS01070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L2bCS78408_RS01110	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L2bCS78408_RS01125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L2bCS78408_RS01240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2bCS78408_RS01250	COG0659	secondary active sulfate transmembrane transporter activity
L2bCS78408_RS01420	COG1560	Kdo2-lipid A biosynthetic process
L2bCS78408_RS01430	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L2bCS78408_RS01435	COG1271	oxidase subunit
L2bCS78408_RS01440	COG1294	oxidase, subunit
L2bCS78408_RS01445	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L2bCS78408_RS01470	COG0681	Belongs to the peptidase S26 family
L2bCS78408_RS01470	COG0681	Belongs to the peptidase S26 family
L2bCS78408_RS01495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2bCS78408_RS01535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2bCS78408_RS01620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L2bCS78408_RS01640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2bCS78408_RS01655	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2bCS78408_RS01675	COG0633	Ferredoxin
L2bCS78408_RS01685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L2bCS78408_RS01690	COG1191	sigma factor activity
L2bCS78408_RS01835	COG4789	Type iii secretion
L2bCS78408_RS01840	COG4792	protein secretion
L2bCS78408_RS01845	COG0012	GTP binding
L2bCS78408_RS01850	COG0196	riboflavin kinase activity
L2bCS78408_RS01870	COG0195	Participates in both transcription termination and antitermination
L2bCS78408_RS01905	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L2bCS78408_RS01915	COG0564	pseudouridine synthase activity
L2bCS78408_RS01945	COG1164	Oligoendopeptidase f
L2bCS78408_RS02005	COG0439	Biotin carboxylase
L2bCS78408_RS02015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2bCS78408_RS02030	COG0765	amino acid transport
L2bCS78408_RS02035	COG1126	abc transporter atp-binding protein
L2bCS78408_RS02080	COG4166	transmembrane transport
L2bCS78408_RS02090	COG3318	Belongs to the UPF0149 family
L2bCS78408_RS02090	COG3012	SEC-C Motif Domain Protein
L2bCS78408_RS02135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2bCS78408_RS02155	COG1136	(ABC) transporter
L2bCS78408_RS02260	COG4166	transmembrane transport
L2bCS78408_RS02285	COG1116	anion transmembrane transporter activity
L2bCS78408_RS02320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L2bCS78408_RS02330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2bCS78408_RS02365	COG2239	Acts as a magnesium transporter
L2bCS78408_RS02385	COG4166	transmembrane transport
L2bCS78408_RS02390	COG0601	transmembrane transport
L2bCS78408_RS02395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2bCS78408_RS02400	COG0444	Belongs to the ABC transporter superfamily
L2bCS78408_RS02405	COG4608	Belongs to the ABC transporter superfamily
L2bCS78408_RS02415	COG0471	metal ion transport
L2bCS78408_RS02420	COG0205	6-phosphofructokinase activity
L2bCS78408_RS02485	COG0531	amino acid
L2bCS78408_RS02490	COG0037	tRNA processing
L2bCS78408_RS02500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2bCS78408_RS02510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L2bCS78408_RS02575	COG0733	neurotransmitter:sodium symporter activity
L2bCS78408_RS02610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2bCS78408_RS02625	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2bCS78408_RS02645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2bCS78408_RS02650	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2bCS78408_RS02650	COG0022	dehydrogenase e1 component
L2bCS78408_RS02655	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2bCS78408_RS02690	COG1266	CAAX protease self-immunity
L2bCS78408_RS02700	COG4536	flavin adenine dinucleotide binding
L2bCS78408_RS02710	COG1104	cysteine desulfurase activity
L2bCS78408_RS02715	COG0631	protein serine/threonine phosphatase activity
L2bCS78408_RS02725	COG2176	DNA-directed DNA polymerase activity
L2bCS78408_RS02730	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
L2bCS78408_RS02740	COG1132	(ABC) transporter
L2bCS78408_RS02760	COG0860	N-Acetylmuramoyl-L-alanine amidase
L2bCS78408_RS02770	COG0768	penicillin binding
L2bCS78408_RS02840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2bCS78408_RS02875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2bCS78408_RS02885	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L2bCS78408_RS02895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2bCS78408_RS03055	COG2166	iron-sulfur cluster assembly
L2bCS78408_RS03115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2bCS78408_RS03150	COG0022	dehydrogenase e1 component
L2bCS78408_RS03190	COG0488	(ABC) transporter
L2bCS78408_RS03230	COG1331	Highly conserved protein containing a thioredoxin domain
L2bCS78408_RS03355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2bCS78408_RS03360	COG0321	lipoyl(octanoyl) transferase activity
L2bCS78408_RS03360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L2bCS78408_RS03370	COG1605	Chorismate mutase
L2bCS78408_RS03370	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L2bCS78408_RS03465	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2bCS78408_RS03470	COG1301	dicarboxylic acid transport
L2bCS78408_RS03480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2bCS78408_RS03500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2bCS78408_RS03510	COG1115	amino acid carrier protein
L2bCS78408_RS03515	COG0617	tRNA 3'-terminal CCA addition
L2bCS78408_RS03610	COG1366	Belongs to the anti-sigma-factor antagonist family
L2bCS78408_RS03620	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L2bCS78408_RS03665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2bCS78408_RS03695	COG0793	Belongs to the peptidase S41A family
L2bCS78408_RS03730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2bCS78408_RS03735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2bCS78408_RS03735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2bCS78408_RS03765	COG0318	PFAM AMP-dependent synthetase and ligase
L2bCS78408_RS03765	COG0204	Acyl-transferase
L2bCS78408_RS03790	COG1247	-acetyltransferase
L2bCS78408_RS03820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2bCS78408_RS03910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2bCS78408_RS03915	COG0601	transmembrane transport
L2bCS78408_RS03960	COG0742	ribosomal rna small subunit methyltransferase
L2bCS78408_RS03970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L2bCS78408_RS03980	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L2bCS78408_RS03990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2bCS78408_RS03990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2bCS78408_RS03995	COG0616	signal peptide processing
L2bCS78408_RS04005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2bCS78408_RS04020	COG0305	Participates in initiation and elongation during chromosome replication
L2bCS78408_RS04220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2bCS78408_RS04245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2bCS78408_RS04300	COG1686	Belongs to the peptidase S11 family
L2bCS78408_RS04315	COG1114	Component of the transport system for branched-chain amino acids
L2bCS78408_RS04340	COG4669	(LipO)protein
L2bCS78408_RS04365	COG4794	Type iii secretion
L2bCS78408_RS04370	COG4791	protein targeting
L2bCS78408_RS04400	COG1459	type II secretion system
L2bCS78408_RS04510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2bCS78408_RS04515	COG1053	succinate dehydrogenase
L2bCS78408_RS04530	COG0084	hydrolase, TatD family'
L2bCS78408_RS04540	COG0811	peptide transport
L2bCS78408_RS04560	COG2885	chlorophyll binding
L2bCS78408_RS04565	COG1388	LysM domain
L2bCS78408_RS04565	COG4641	Protein conserved in bacteria
L2bCS78408_RS04575	COG0450	alkyl hydroperoxide reductase
L2bCS78408_RS04585	COG0459	protein refolding
L2bCS78408_RS04590	COG3876	Protein conserved in bacteria
L2bCS78408_RS04610	COG0210	DNA helicase
L2bCS78408_RS04615	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L2bCS78408_RS04715	COG0142	geranyltranstransferase activity
L2bCS78408_RS04720	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain