locus-tag	class	description
BKC02_RS00055	COG1560	Kdo2-lipid A biosynthetic process
BKC02_RS00065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BKC02_RS00070	COG1271	oxidase subunit
BKC02_RS00075	COG1294	oxidase, subunit
BKC02_RS00080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BKC02_RS00110	COG0681	Belongs to the peptidase S26 family
BKC02_RS00135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BKC02_RS00175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BKC02_RS00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BKC02_RS00280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BKC02_RS00290	COG0567	Dehydrogenase, E1 component
BKC02_RS00290	COG0508	dehydrogenase complex catalyzes the overall conversion of
BKC02_RS00295	COG0508	dehydrogenase complex catalyzes the overall conversion of
BKC02_RS00315	COG0633	Ferredoxin
BKC02_RS00325	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BKC02_RS00330	COG1191	sigma factor activity
BKC02_RS00480	COG4789	Type iii secretion
BKC02_RS00485	COG4792	protein secretion
BKC02_RS00490	COG0012	GTP binding
BKC02_RS00495	COG0196	riboflavin kinase activity
BKC02_RS00515	COG0195	Participates in both transcription termination and antitermination
BKC02_RS00550	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BKC02_RS00560	COG0564	pseudouridine synthase activity
BKC02_RS00590	COG1164	Oligoendopeptidase f
BKC02_RS00650	COG0439	Biotin carboxylase
BKC02_RS00675	COG0765	amino acid transport
BKC02_RS00680	COG1126	abc transporter atp-binding protein
BKC02_RS00725	COG4166	transmembrane transport
BKC02_RS00735	COG3318	Belongs to the UPF0149 family
BKC02_RS00735	COG3012	SEC-C Motif Domain Protein
BKC02_RS00780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BKC02_RS00800	COG1136	(ABC) transporter
BKC02_RS00910	COG4166	transmembrane transport
BKC02_RS00935	COG1116	anion transmembrane transporter activity
BKC02_RS00970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BKC02_RS00980	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BKC02_RS01015	COG2239	Acts as a magnesium transporter
BKC02_RS01035	COG4166	transmembrane transport
BKC02_RS01040	COG0601	transmembrane transport
BKC02_RS01045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BKC02_RS01050	COG0444	Belongs to the ABC transporter superfamily
BKC02_RS01055	COG4608	Belongs to the ABC transporter superfamily
BKC02_RS01065	COG0471	metal ion transport
BKC02_RS01070	COG0205	6-phosphofructokinase activity
BKC02_RS01135	COG0531	amino acid
BKC02_RS01140	COG0037	tRNA processing
BKC02_RS01150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BKC02_RS01160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BKC02_RS01225	COG0733	neurotransmitter:sodium symporter activity
BKC02_RS01260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BKC02_RS01275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BKC02_RS01295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BKC02_RS01300	COG0508	dehydrogenase complex catalyzes the overall conversion of
BKC02_RS01300	COG0022	dehydrogenase e1 component
BKC02_RS01305	COG0508	dehydrogenase complex catalyzes the overall conversion of
BKC02_RS01340	COG1266	CAAX protease self-immunity
BKC02_RS01355	COG4536	flavin adenine dinucleotide binding
BKC02_RS01365	COG1104	cysteine desulfurase activity
BKC02_RS01370	COG0631	protein serine/threonine phosphatase activity
BKC02_RS01380	COG2176	DNA-directed DNA polymerase activity
BKC02_RS01385	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BKC02_RS01395	COG1132	(ABC) transporter
BKC02_RS01415	COG0860	N-Acetylmuramoyl-L-alanine amidase
BKC02_RS01425	COG0768	penicillin binding
BKC02_RS01495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BKC02_RS01530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BKC02_RS01540	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BKC02_RS01550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BKC02_RS01710	COG2166	iron-sulfur cluster assembly
BKC02_RS01780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BKC02_RS01815	COG0022	dehydrogenase e1 component
BKC02_RS01855	COG0488	(ABC) transporter
BKC02_RS01895	COG1331	Highly conserved protein containing a thioredoxin domain
BKC02_RS02020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BKC02_RS02025	COG0321	lipoyl(octanoyl) transferase activity
BKC02_RS02025	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BKC02_RS02035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BKC02_RS02035	COG1605	Chorismate mutase
BKC02_RS02135	COG0508	dehydrogenase complex catalyzes the overall conversion of
BKC02_RS02140	COG1301	dicarboxylic acid transport
BKC02_RS02170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BKC02_RS02180	COG1115	amino acid carrier protein
BKC02_RS02185	COG0617	tRNA 3'-terminal CCA addition
BKC02_RS02275	COG1366	Belongs to the anti-sigma-factor antagonist family
BKC02_RS02290	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BKC02_RS02335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BKC02_RS02365	COG0793	Belongs to the peptidase S41A family
BKC02_RS02400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BKC02_RS02405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BKC02_RS02405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BKC02_RS02440	COG0318	PFAM AMP-dependent synthetase and ligase
BKC02_RS02440	COG0204	Acyl-transferase
BKC02_RS02465	COG1247	-acetyltransferase
BKC02_RS02495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BKC02_RS02585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BKC02_RS02590	COG0601	transmembrane transport
BKC02_RS02635	COG0742	ribosomal rna small subunit methyltransferase
BKC02_RS02645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BKC02_RS02655	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BKC02_RS02665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BKC02_RS02665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BKC02_RS02670	COG0616	signal peptide processing
BKC02_RS02680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BKC02_RS02695	COG0305	Participates in initiation and elongation during chromosome replication
BKC02_RS02900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BKC02_RS02925	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BKC02_RS02985	COG1686	Belongs to the peptidase S11 family
BKC02_RS03035	COG4669	(LipO)protein
BKC02_RS03060	COG4794	Type iii secretion
BKC02_RS03065	COG4791	protein targeting
BKC02_RS03095	COG1459	type II secretion system
BKC02_RS03200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BKC02_RS03220	COG0084	hydrolase, TatD family'
BKC02_RS03230	COG0811	peptide transport
BKC02_RS03250	COG2885	chlorophyll binding
BKC02_RS03255	COG1388	LysM domain
BKC02_RS03255	COG4641	Protein conserved in bacteria
BKC02_RS03265	COG0450	alkyl hydroperoxide reductase
BKC02_RS03275	COG0459	protein refolding
BKC02_RS03280	COG3876	Protein conserved in bacteria
BKC02_RS03300	COG0210	DNA helicase
BKC02_RS03305	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BKC02_RS03405	COG0142	geranyltranstransferase activity
BKC02_RS03410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BKC02_RS03480	COG2814	Major facilitator Superfamily
BKC02_RS03490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BKC02_RS03495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BKC02_RS03520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BKC02_RS03535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BKC02_RS03575	COG0564	pseudouridine synthase activity
BKC02_RS03650	COG2815	serine threonine protein kinase
BKC02_RS03650	COG0515	serine threonine protein kinase
BKC02_RS03720	COG0768	penicillin binding
BKC02_RS03730	COG0719	Fe-S assembly protein
BKC02_RS03735	COG0396	ATPase activity
BKC02_RS03740	COG0719	Fe-S assembly protein
BKC02_RS03755	COG4608	Belongs to the ABC transporter superfamily
BKC02_RS03760	COG0444	Belongs to the ABC transporter superfamily
BKC02_RS03795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BKC02_RS03860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BKC02_RS03865	COG1077	Cell shape determining protein MreB Mrl
BKC02_RS03895	COG4284	Utp--glucose-1-phosphate uridylyltransferase
BKC02_RS03935	COG1187	pseudouridine synthase activity
BKC02_RS03945	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BKC02_RS03945	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BKC02_RS03950	COG0772	Belongs to the SEDS family
BKC02_RS03995	COG1115	amino acid carrier protein
BKC02_RS04010	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BKC02_RS04070	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BKC02_RS04075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BKC02_RS04085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BKC02_RS04115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BKC02_RS04140	COG0459	protein refolding
BKC02_RS04150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BKC02_RS04170	COG0772	Belongs to the SEDS family
BKC02_RS04185	COG1837	Belongs to the UPF0109 family
BKC02_RS04195	COG1366	Belongs to the anti-sigma-factor antagonist family
BKC02_RS04205	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BKC02_RS04215	COG0799	negative regulation of ribosome biogenesis
BKC02_RS04220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BKC02_RS04245	COG1218	3'(2'),5'-bisphosphate nucleotidase
BKC02_RS04260	COG0156	8-amino-7-oxononanoate synthase activity
BKC02_RS04275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BKC02_RS04290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BKC02_RS04425	COG1025	Belongs to the peptidase M16 family
BKC02_RS04490	COG0814	amino acid
BKC02_RS04495	COG0814	amino acid
BKC02_RS04505	COG0552	protein localization to endoplasmic reticulum
BKC02_RS04515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BKC02_RS04565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BKC02_RS04695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BKC02_RS04705	COG0659	secondary active sulfate transmembrane transporter activity