locus-tag	class	description
B6V80_RS00055	COG1560	Kdo2-lipid A biosynthetic process
B6V80_RS00065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B6V80_RS00070	COG1271	oxidase subunit
B6V80_RS00075	COG1294	oxidase, subunit
B6V80_RS00080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B6V80_RS00110	COG0681	Belongs to the peptidase S26 family
B6V80_RS00135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6V80_RS00175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6V80_RS00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B6V80_RS00280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B6V80_RS00295	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6V80_RS00325	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B6V80_RS00330	COG1191	sigma factor activity
B6V80_RS00480	COG4789	Type iii secretion
B6V80_RS00485	COG4792	protein secretion
B6V80_RS00490	COG0012	GTP binding
B6V80_RS00495	COG0196	riboflavin kinase activity
B6V80_RS00515	COG0195	Participates in both transcription termination and antitermination
B6V80_RS00550	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B6V80_RS00560	COG0564	pseudouridine synthase activity
B6V80_RS00590	COG1164	Oligoendopeptidase f
B6V80_RS00650	COG0439	Biotin carboxylase
B6V80_RS00675	COG0765	amino acid transport
B6V80_RS00680	COG1126	abc transporter atp-binding protein
B6V80_RS00725	COG4166	transmembrane transport
B6V80_RS00735	COG3318	Belongs to the UPF0149 family
B6V80_RS00735	COG3012	SEC-C Motif Domain Protein
B6V80_RS00780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6V80_RS00800	COG1136	(ABC) transporter
B6V80_RS00915	COG4166	transmembrane transport
B6V80_RS00940	COG1116	anion transmembrane transporter activity
B6V80_RS00975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B6V80_RS00985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B6V80_RS01020	COG2239	Acts as a magnesium transporter
B6V80_RS01040	COG4166	transmembrane transport
B6V80_RS01045	COG0601	transmembrane transport
B6V80_RS01050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6V80_RS01055	COG0444	Belongs to the ABC transporter superfamily
B6V80_RS01060	COG4608	Belongs to the ABC transporter superfamily
B6V80_RS01070	COG0471	metal ion transport
B6V80_RS01075	COG0205	6-phosphofructokinase activity
B6V80_RS01140	COG0531	amino acid
B6V80_RS01145	COG0037	tRNA processing
B6V80_RS01155	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B6V80_RS01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6V80_RS01225	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B6V80_RS01230	COG0733	neurotransmitter:sodium symporter activity
B6V80_RS01265	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B6V80_RS01280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6V80_RS01300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B6V80_RS01305	COG0022	dehydrogenase e1 component
B6V80_RS01305	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6V80_RS01310	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6V80_RS01345	COG1266	CAAX protease self-immunity
B6V80_RS01360	COG4536	flavin adenine dinucleotide binding
B6V80_RS01370	COG1104	cysteine desulfurase activity
B6V80_RS01375	COG0631	protein serine/threonine phosphatase activity
B6V80_RS01395	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B6V80_RS01405	COG1132	(ABC) transporter
B6V80_RS01425	COG0860	N-Acetylmuramoyl-L-alanine amidase
B6V80_RS01440	COG0768	penicillin binding
B6V80_RS01510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B6V80_RS01545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6V80_RS01555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B6V80_RS01565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6V80_RS01725	COG2166	iron-sulfur cluster assembly
B6V80_RS01795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B6V80_RS01830	COG0022	dehydrogenase e1 component
B6V80_RS01870	COG0488	(ABC) transporter
B6V80_RS01910	COG1331	Highly conserved protein containing a thioredoxin domain
B6V80_RS02035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6V80_RS02040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B6V80_RS02040	COG0321	lipoyl(octanoyl) transferase activity
B6V80_RS02050	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B6V80_RS02050	COG1605	Chorismate mutase
B6V80_RS02150	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6V80_RS02155	COG1301	dicarboxylic acid transport
B6V80_RS02185	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B6V80_RS02195	COG1115	amino acid carrier protein
B6V80_RS02200	COG0617	tRNA 3'-terminal CCA addition
B6V80_RS02290	COG1366	Belongs to the anti-sigma-factor antagonist family
B6V80_RS02305	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B6V80_RS02350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B6V80_RS02380	COG0793	Belongs to the peptidase S41A family
B6V80_RS02415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B6V80_RS02420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6V80_RS02420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6V80_RS02455	COG0204	Acyl-transferase
B6V80_RS02455	COG0318	PFAM AMP-dependent synthetase and ligase
B6V80_RS02480	COG1247	-acetyltransferase
B6V80_RS02510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6V80_RS02600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6V80_RS02605	COG0601	transmembrane transport
B6V80_RS02650	COG0742	ribosomal rna small subunit methyltransferase
B6V80_RS02660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B6V80_RS02670	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B6V80_RS02680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6V80_RS02680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6V80_RS02685	COG0616	signal peptide processing
B6V80_RS02695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B6V80_RS02710	COG0305	Participates in initiation and elongation during chromosome replication
B6V80_RS02915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6V80_RS02940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B6V80_RS03000	COG1686	Belongs to the peptidase S11 family
B6V80_RS03050	COG4669	(LipO)protein
B6V80_RS03075	COG4794	Type iii secretion
B6V80_RS03080	COG4791	protein targeting
B6V80_RS03110	COG1459	type II secretion system
B6V80_RS03215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B6V80_RS03235	COG0084	hydrolase, TatD family'
B6V80_RS03245	COG0811	peptide transport
B6V80_RS03265	COG2885	chlorophyll binding
B6V80_RS03270	COG4641	Protein conserved in bacteria
B6V80_RS03270	COG1388	LysM domain
B6V80_RS03280	COG0450	alkyl hydroperoxide reductase
B6V80_RS03290	COG0459	protein refolding
B6V80_RS03295	COG3876	Protein conserved in bacteria
B6V80_RS03315	COG0210	DNA helicase
B6V80_RS03320	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B6V80_RS03420	COG0142	geranyltranstransferase activity
B6V80_RS03425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6V80_RS03495	COG2814	Major facilitator Superfamily
B6V80_RS03505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6V80_RS03510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B6V80_RS03535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B6V80_RS03550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6V80_RS03590	COG0564	pseudouridine synthase activity
B6V80_RS03665	COG0515	serine threonine protein kinase
B6V80_RS03665	COG2815	serine threonine protein kinase
B6V80_RS03735	COG0768	penicillin binding
B6V80_RS03745	COG0719	Fe-S assembly protein
B6V80_RS03750	COG0396	ATPase activity
B6V80_RS03755	COG0719	Fe-S assembly protein
B6V80_RS03770	COG4608	Belongs to the ABC transporter superfamily
B6V80_RS03775	COG0444	Belongs to the ABC transporter superfamily
B6V80_RS03810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B6V80_RS03875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B6V80_RS03880	COG1077	Cell shape determining protein MreB Mrl
B6V80_RS03910	COG4284	Utp--glucose-1-phosphate uridylyltransferase
B6V80_RS03950	COG1187	pseudouridine synthase activity
B6V80_RS03960	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B6V80_RS03960	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B6V80_RS03965	COG0772	Belongs to the SEDS family
B6V80_RS04010	COG1115	amino acid carrier protein
B6V80_RS04025	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B6V80_RS04085	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B6V80_RS04090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B6V80_RS04100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B6V80_RS04130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B6V80_RS04155	COG0459	protein refolding
B6V80_RS04165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6V80_RS04185	COG0772	Belongs to the SEDS family
B6V80_RS04200	COG1837	Belongs to the UPF0109 family
B6V80_RS04210	COG1366	Belongs to the anti-sigma-factor antagonist family
B6V80_RS04220	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B6V80_RS04230	COG0799	negative regulation of ribosome biogenesis
B6V80_RS04235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6V80_RS04260	COG1218	3'(2'),5'-bisphosphate nucleotidase
B6V80_RS04275	COG0156	8-amino-7-oxononanoate synthase activity
B6V80_RS04290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6V80_RS04305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6V80_RS04440	COG1025	Belongs to the peptidase M16 family
B6V80_RS04505	COG0814	amino acid
B6V80_RS04510	COG0814	amino acid
B6V80_RS04520	COG0552	protein localization to endoplasmic reticulum
B6V80_RS04530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B6V80_RS04580	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B6V80_RS04710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6V80_RS04720	COG0659	secondary active sulfate transmembrane transporter activity