locus-tag	class	description
CLIM_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLIM_RS00010	COG0592	DNA-directed DNA polymerase activity
CLIM_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLIM_RS00025	COG0426	domain, Protein
CLIM_RS00035	COG0445	tRNA wobble uridine modification
CLIM_RS00055	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLIM_RS00060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLIM_RS00065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLIM_RS00070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLIM_RS00075	COG0187	DNA topoisomerase II activity
CLIM_RS00080	COG0792	nuclease activity
CLIM_RS00085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLIM_RS00090	COG1530	ribonuclease E activity
CLIM_RS00095	COG2171	N-acyltransferase activity
CLIM_RS00100	COG0793	Belongs to the peptidase S41A family
CLIM_RS00110	COG0644	oxidoreductase
CLIM_RS00115	COG0423	glycine-tRNA ligase activity
CLIM_RS00130	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLIM_RS00140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLIM_RS00150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLIM_RS00155	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CLIM_RS00165	COG3360	Dodecin
CLIM_RS00175	COG0243	molybdopterin cofactor binding
CLIM_RS00190	COG0425	Belongs to the sulfur carrier protein TusA family
CLIM_RS00195	COG2210	Belongs to the sulfur carrier protein TusA family
CLIM_RS00205	COG0514	ATP-dependent DNA helicase (RecQ)
CLIM_RS00260	COG0515	serine threonine protein kinase
CLIM_RS00260	COG2815	serine threonine protein kinase
CLIM_RS00300	COG2091	lysine biosynthetic process via aminoadipic acid
CLIM_RS00330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLIM_RS00340	COG2814	Major facilitator Superfamily
CLIM_RS00350	COG0589	response to stress
CLIM_RS00355	COG1538	Outer membrane efflux protein
CLIM_RS00365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLIM_RS00375	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CLIM_RS00390	COG0003	Pfam Anion-transporting ATPase
CLIM_RS00415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLIM_RS00420	COG0750	zinc metalloprotease
CLIM_RS00425	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLIM_RS00435	COG1254	Belongs to the acylphosphatase family
CLIM_RS00440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLIM_RS00445	COG0284	orotidine-5'-phosphate decarboxylase activity
CLIM_RS00450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLIM_RS00460	COG1090	epimerase
CLIM_RS00470	COG0724	RNA recognition motif
CLIM_RS00490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLIM_RS00510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLIM_RS00515	COG0799	negative regulation of ribosome biogenesis
CLIM_RS00520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLIM_RS00530	COG0504	CTP synthase activity
CLIM_RS00660	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CLIM_RS00670	COG0640	Transcriptional regulator
CLIM_RS00685	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CLIM_RS00710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLIM_RS00715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLIM_RS00765	COG0859	PFAM glycosyl transferase family 9
CLIM_RS00770	COG0708	Exodeoxyribonuclease III
CLIM_RS00775	COG0360	Binds together with S18 to 16S ribosomal RNA
CLIM_RS00780	COG0629	single-stranded DNA binding
CLIM_RS00785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLIM_RS00790	COG0359	binds to the 23S rRNA
CLIM_RS00800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLIM_RS00805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLIM_RS00810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLIM_RS00815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLIM_RS00820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLIM_RS00825	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CLIM_RS00830	COG1472	Belongs to the glycosyl hydrolase 3 family
CLIM_RS00835	COG0252	asparaginase activity
CLIM_RS00855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLIM_RS00860	COG0571	ribonuclease III activity
CLIM_RS00865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLIM_RS00870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLIM_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
CLIM_RS00880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLIM_RS00885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLIM_RS00890	COG0416	fatty acid biosynthetic process
CLIM_RS00920	COG5002	protein histidine kinase activity
CLIM_RS00930	COG1773	rubredoxin
CLIM_RS00940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLIM_RS00945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLIM_RS00955	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLIM_RS00975	COG0463	Glycosyl transferase, family 2
CLIM_RS00980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLIM_RS00985	COG0148	phosphopyruvate hydratase activity
CLIM_RS00995	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLIM_RS01000	COG0300	oxidoreductase activity
CLIM_RS01030	COG0250	Participates in transcription elongation, termination and antitermination
CLIM_RS01035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLIM_RS01040	COG0081	regulation of translation
CLIM_RS01045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLIM_RS01050	COG0222	ribosome binding
CLIM_RS01055	COG0085	RNA polymerase activity
CLIM_RS01060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLIM_RS01065	COG0439	Biotin carboxylase
CLIM_RS01070	COG0511	ligase activity, forming carbon-carbon bonds
CLIM_RS01075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLIM_RS01085	COG0825	malonyl-CoA metabolic process
CLIM_RS01090	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLIM_RS01095	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLIM_RS01095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLIM_RS01105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLIM_RS01110	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLIM_RS01125	COG3550	peptidyl-serine autophosphorylation
CLIM_RS01150	COG0560	Phosphoserine phosphatase
CLIM_RS01150	COG3830	Belongs to the UPF0237 family
CLIM_RS01170	COG0582	viral genome integration into host DNA
CLIM_RS01225	COG3576	pyridoxamine 5-phosphate
CLIM_RS01260	COG0519	Catalyzes the synthesis of GMP from XMP
CLIM_RS01260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLIM_RS01265	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CLIM_RS01270	COG2267	carboxylic ester hydrolase activity
CLIM_RS01275	COG0586	Pfam SNARE associated Golgi protein
CLIM_RS01285	COG1233	COG1233 Phytoene dehydrogenase and related
CLIM_RS01305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLIM_RS01335	COG0542	response to heat
CLIM_RS01340	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CLIM_RS01355	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CLIM_RS01360	COG0552	protein localization to endoplasmic reticulum
CLIM_RS01370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CLIM_RS01375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLIM_RS01380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLIM_RS01385	COG0305	Participates in initiation and elongation during chromosome replication
CLIM_RS01390	COG1573	uracil-dna glycosylase
CLIM_RS01395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLIM_RS01405	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CLIM_RS01405	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CLIM_RS01415	COG1560	Kdo2-lipid A biosynthetic process
CLIM_RS01420	COG1132	(ABC) transporter
CLIM_RS01440	COG0438	transferase activity, transferring glycosyl groups
CLIM_RS01455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLIM_RS01465	COG0438	transferase activity, transferring glycosyl groups
CLIM_RS01470	COG0438	transferase activity, transferring glycosyl groups
CLIM_RS01495	COG0438	transferase activity, transferring glycosyl groups
CLIM_RS01515	COG4589	Belongs to the CDS family
CLIM_RS01520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLIM_RS01525	COG0124	histidyl-tRNA synthetase
CLIM_RS01540	COG0779	Required for maturation of 30S ribosomal subunits
CLIM_RS01545	COG0195	Participates in both transcription termination and antitermination
CLIM_RS01550	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLIM_RS01555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLIM_RS01560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLIM_RS01565	COG0196	riboflavin kinase activity
CLIM_RS01570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLIM_RS01575	COG1561	YicC-like family, N-terminal region
CLIM_RS01580	COG0194	GDP metabolic process
CLIM_RS01595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLIM_RS01600	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CLIM_RS01620	COG0758	DNA mediated transformation
CLIM_RS01630	COG1304	FMN binding
CLIM_RS01640	COG1132	(ABC) transporter
CLIM_RS01645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLIM_RS01650	COG0268	Binds directly to 16S ribosomal RNA
CLIM_RS01655	COG0632	four-way junction helicase activity
CLIM_RS01660	COG0285	dihydrofolate synthase activity
CLIM_RS01665	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLIM_RS01690	COG2226	methyltransferase
CLIM_RS01700	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLIM_RS01720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLIM_RS01725	COG0154	amidase activity
CLIM_RS01730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CLIM_RS01735	COG0517	IMP dehydrogenase activity
CLIM_RS01735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CLIM_RS01765	COG1595	DNA-templated transcription, initiation
CLIM_RS01770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLIM_RS01775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLIM_RS01790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLIM_RS01795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLIM_RS01800	COG0012	GTP binding
CLIM_RS01805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLIM_RS01810	COG0539	negative regulation of cytoplasmic translation
CLIM_RS01815	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLIM_RS01820	COG0772	Belongs to the SEDS family
CLIM_RS01825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLIM_RS01830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLIM_RS01850	COG0730	response to heat
CLIM_RS01855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLIM_RS01860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLIM_RS01880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CLIM_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
CLIM_RS01945	COG0573	inorganic phosphate transmembrane transporter activity
CLIM_RS01950	COG0581	inorganic phosphate transmembrane transporter activity
CLIM_RS01955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLIM_RS01965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLIM_RS01970	COG0243	molybdopterin cofactor binding
CLIM_RS01980	COG0233	cytoplasmic translational termination
CLIM_RS01985	COG0254	rRNA binding
CLIM_RS01990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLIM_RS01995	COG1162	GTPase activity
CLIM_RS02000	COG1012	belongs to the aldehyde dehydrogenase family
CLIM_RS02020	COG1597	lipid kinase activity
CLIM_RS02035	COG1611	Belongs to the LOG family
CLIM_RS02055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLIM_RS02060	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CLIM_RS02065	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLIM_RS02070	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLIM_RS02075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLIM_RS02080	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CLIM_RS02085	COG0740	serine-type endopeptidase activity
CLIM_RS02090	COG0525	valine-tRNA ligase activity
CLIM_RS02095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLIM_RS02110	COG0612	Peptidase, M16
CLIM_RS02115	COG0556	nucleotide-excision repair
CLIM_RS02120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLIM_RS02125	COG1704	LemA family
CLIM_RS02130	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CLIM_RS02140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLIM_RS02145	COG1674	ftsk spoiiie
CLIM_RS02150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CLIM_RS02155	COG0489	protein tyrosine kinase activity
CLIM_RS02160	COG1160	GTP binding
CLIM_RS02165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLIM_RS02170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLIM_RS02175	COG0052	Belongs to the universal ribosomal protein uS2 family
CLIM_RS02180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLIM_RS02185	COG0528	UMP kinase activity
CLIM_RS02190	COG2137	regulation of response to DNA damage stimulus
CLIM_RS02195	COG0494	nUDIX hydrolase
CLIM_RS02200	COG2814	Major facilitator Superfamily
CLIM_RS02205	COG1785	Belongs to the alkaline phosphatase family
CLIM_RS02220	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLIM_RS02280	COG1203	CRISPR-associated helicase, Cas3
CLIM_RS02285	COG1518	maintenance of DNA repeat elements
CLIM_RS02290	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CLIM_RS02300	COG0823	Involved in the tonB-independent uptake of proteins
CLIM_RS02315	COG0205	6-phosphofructokinase activity
CLIM_RS02330	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLIM_RS02335	COG0574	Belongs to the PEP-utilizing enzyme family
CLIM_RS02335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLIM_RS02340	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLIM_RS02345	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CLIM_RS02365	COG1663	tetraacyldisaccharide 4'-kinase activity
CLIM_RS02375	COG0151	Belongs to the GarS family
CLIM_RS02385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLIM_RS02390	COG0134	indole-3-glycerol-phosphate synthase activity
CLIM_RS02395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLIM_RS02410	COG0739	heme binding
CLIM_RS02420	COG1605	Chorismate mutase
CLIM_RS02420	COG0077	Prephenate dehydratase
CLIM_RS02425	COG0217	transcriptional regulatory protein
CLIM_RS02430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CLIM_RS02435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLIM_RS02445	COG0450	alkyl hydroperoxide reductase
CLIM_RS02450	COG0735	belongs to the Fur family
CLIM_RS02460	COG0557	exoribonuclease II activity
CLIM_RS02470	COG2205	protein histidine kinase activity
CLIM_RS02470	COG0784	Response regulator, receiver
CLIM_RS02500	COG2916	Histone family protein nucleoid-structuring protein H-NS
CLIM_RS02510	COG0133	tryptophan synthase activity
CLIM_RS02515	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CLIM_RS02530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLIM_RS02540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLIM_RS02545	COG0459	protein refolding
CLIM_RS02550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLIM_RS02560	COG0159	tryptophan synthase activity
CLIM_RS02590	COG3015	lipoprotein NlpE involved in copper resistance
CLIM_RS02600	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
CLIM_RS02605	COG0438	transferase activity, transferring glycosyl groups
CLIM_RS02610	COG1077	Cell shape determining protein MreB Mrl
CLIM_RS02615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLIM_RS02620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLIM_RS02625	COG1049	propionate catabolic process, 2-methylcitrate cycle
CLIM_RS02665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLIM_RS02670	COG4942	peptidase
CLIM_RS02670	COG1388	LysM domain
CLIM_RS02680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLIM_RS02685	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CLIM_RS02690	COG0586	Pfam SNARE associated Golgi protein
CLIM_RS02695	COG1945	arginine decarboxylase activity
CLIM_RS02700	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLIM_RS02705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLIM_RS02710	COG0277	FAD linked oxidase domain protein
CLIM_RS02715	COG0768	penicillin binding
CLIM_RS02725	COG1792	Involved in formation and maintenance of cell shape
CLIM_RS02735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLIM_RS02740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CLIM_RS02765	COG2884	Cell division ATP-binding protein ftsE
CLIM_RS02770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CLIM_RS02785	COG0513	Belongs to the DEAD box helicase family
CLIM_RS02790	COG1519	Transferase
CLIM_RS02810	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CLIM_RS02820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CLIM_RS02835	COG1741	Belongs to the pirin family
CLIM_RS02840	COG1692	metallophosphoesterase
CLIM_RS02850	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CLIM_RS02855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLIM_RS02855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLIM_RS02860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLIM_RS02860	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CLIM_RS02875	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CLIM_RS02940	COG3621	Patatin-like phospholipase
CLIM_RS02945	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CLIM_RS03035	COG3411	Ferredoxin
CLIM_RS03040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLIM_RS03045	COG0495	leucyl-tRNA aminoacylation
CLIM_RS03050	COG1185	polyribonucleotide nucleotidyltransferase activity
CLIM_RS03055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CLIM_RS03060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLIM_RS03065	COG4608	Belongs to the ABC transporter superfamily
CLIM_RS03070	COG0616	signal peptide processing
CLIM_RS03080	COG0606	chelatase, subunit chli
CLIM_RS03085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CLIM_RS03090	COG3245	cytochrome
CLIM_RS03095	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLIM_RS03100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CLIM_RS03110	COG4974	Belongs to the 'phage' integrase family
CLIM_RS03120	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CLIM_RS03130	COG0601	transmembrane transport
CLIM_RS03135	COG2255	four-way junction helicase activity
CLIM_RS03145	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLIM_RS03145	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLIM_RS03145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CLIM_RS03145	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLIM_RS03150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLIM_RS03155	COG0509	glycine decarboxylation via glycine cleavage system
CLIM_RS03160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLIM_RS03165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLIM_RS03170	COG0497	DNA recombination
CLIM_RS03175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLIM_RS03180	COG0688	phosphatidylethanolamine metabolic process
CLIM_RS03185	COG0037	tRNA processing
CLIM_RS03195	COG0328	RNA-DNA hybrid ribonuclease activity
CLIM_RS03200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLIM_RS03205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CLIM_RS03210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLIM_RS03220	COG1324	tolerance protein
CLIM_RS03230	COG0463	Glycosyl transferase, family 2
CLIM_RS03235	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CLIM_RS03245	COG0788	formyltetrahydrofolate deformylase activity
CLIM_RS03250	COG3040	lipid binding
CLIM_RS03320	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CLIM_RS03335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CLIM_RS03345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLIM_RS03350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLIM_RS03355	COG2022	thiamine diphosphate biosynthetic process
CLIM_RS03365	COG0626	cystathionine gamma-synthase activity
CLIM_RS03385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLIM_RS03395	COG4662	Binding-protein-dependent transport system inner membrane component
CLIM_RS03415	COG0535	radical SAM domain protein
CLIM_RS03415	COG1433	Dinitrogenase iron-molybdenum cofactor
CLIM_RS03440	COG0347	Belongs to the P(II) protein family
CLIM_RS03450	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CLIM_RS03460	COG0667	Aldo Keto reductase
CLIM_RS03465	COG5002	protein histidine kinase activity
CLIM_RS03465	COG2205	protein histidine kinase activity
CLIM_RS03465	COG0784	Response regulator, receiver
CLIM_RS03475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLIM_RS03485	COG1797	cobyrinic acid a,c-diamide synthase activity
CLIM_RS03490	COG2920	part of a sulfur-relay system
CLIM_RS03495	COG2221	Nitrite and sulphite reductase 4Fe-4S
CLIM_RS03500	COG2221	Nitrite and sulphite reductase 4Fe-4S
CLIM_RS03520	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CLIM_RS03525	COG2923	Belongs to the DsrF TusC family
CLIM_RS03530	COG2168	tRNA wobble position uridine thiolation
CLIM_RS03555	COG0437	4 iron, 4 sulfur cluster binding
CLIM_RS03565	COG1648	precorrin-2 dehydrogenase activity
CLIM_RS03565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLIM_RS03630	COG3011	Protein conserved in bacteria
CLIM_RS03640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLIM_RS03645	COG4115	mRNA cleavage
CLIM_RS03670	COG1305	Transglutaminase-like
CLIM_RS03680	COG2308	Evidence 4 Homologs of previously reported genes of
CLIM_RS03690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLIM_RS03695	COG0066	3-isopropylmalate dehydratase activity
CLIM_RS03700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLIM_RS03705	COG0473	3-isopropylmalate dehydrogenase activity
CLIM_RS03710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLIM_RS03715	COG0440	acetolactate synthase activity
CLIM_RS03720	COG0028	Belongs to the TPP enzyme family
CLIM_RS03725	COG0129	dihydroxy-acid dehydratase activity
CLIM_RS03740	COG0811	peptide transport
CLIM_RS03755	COG0823	Involved in the tonB-independent uptake of proteins
CLIM_RS03760	COG2885	chlorophyll binding
CLIM_RS03765	COG2885	chlorophyll binding
CLIM_RS03790	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLIM_RS03805	COG0716	FMN binding
CLIM_RS03825	COG0443	Heat shock 70 kDa protein
CLIM_RS03830	COG0071	Belongs to the small heat shock protein (HSP20) family
CLIM_RS03845	COG1595	DNA-templated transcription, initiation
CLIM_RS03860	COG0633	Ferredoxin
CLIM_RS03865	COG0633	Ferredoxin
CLIM_RS03870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLIM_RS03875	COG0444	Belongs to the ABC transporter superfamily
CLIM_RS03880	COG0745	RESPONSE REGULATOR receiver
CLIM_RS03885	COG5002	protein histidine kinase activity
CLIM_RS03890	COG0668	transmembrane transport
CLIM_RS03900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLIM_RS03905	COG1678	Uncharacterized ACR, COG1678
CLIM_RS03920	COG4942	peptidase
CLIM_RS03975	COG1115	amino acid carrier protein
CLIM_RS03985	COG2326	polyphosphate kinase activity
CLIM_RS03995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CLIM_RS04000	COG2089	acid synthase
CLIM_RS04015	COG0326	Molecular chaperone. Has ATPase activity
CLIM_RS04030	COG0589	response to stress
CLIM_RS04065	COG1554	hydrolase, family 65, central catalytic
CLIM_RS04075	COG3118	belongs to the thioredoxin family
CLIM_RS04080	COG0492	ferredoxin-NADP+ reductase activity
CLIM_RS04090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLIM_RS04115	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CLIM_RS04130	COG0546	phosphoglycolate phosphatase activity
CLIM_RS04135	COG4106	trans-aconitate 2-methyltransferase activity
CLIM_RS04135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CLIM_RS04155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLIM_RS04155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLIM_RS04175	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CLIM_RS04190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLIM_RS04240	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLIM_RS04245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLIM_RS04250	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLIM_RS04255	COG0649	NAD binding
CLIM_RS04260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CLIM_RS04275	COG0713	ATP synthesis coupled electron transport
CLIM_RS04280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLIM_RS04290	COG1007	ATP synthesis coupled electron transport
CLIM_RS04295	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CLIM_RS04300	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CLIM_RS04305	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CLIM_RS04310	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CLIM_RS04315	COG0302	gtp cyclohydrolase
CLIM_RS04330	COG3118	belongs to the thioredoxin family
CLIM_RS04335	COG2738	Putative neutral zinc metallopeptidase
CLIM_RS04340	COG1030	water channel activity
CLIM_RS04345	COG0330	HflC and HflK could
CLIM_RS04355	COG1703	isobutyryl-CoA mutase activity
CLIM_RS04360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLIM_RS04360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLIM_RS04365	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLIM_RS04365	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CLIM_RS04370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLIM_RS04375	COG0346	lactoylglutathione lyase activity
CLIM_RS04385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLIM_RS04390	COG3958	Transketolase
CLIM_RS04395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLIM_RS04400	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CLIM_RS04405	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CLIM_RS04405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CLIM_RS04425	COG2217	Heavy metal translocating P-type atpase
CLIM_RS04435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLIM_RS04440	COG0113	porphobilinogen synthase activity
CLIM_RS04460	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CLIM_RS04465	COG0511	ligase activity, forming carbon-carbon bonds
CLIM_RS04475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CLIM_RS04490	COG1587	Uroporphyrinogen-III synthase
CLIM_RS04495	COG0181	hydroxymethylbilane synthase activity
CLIM_RS04500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLIM_RS04510	COG1217	gtp-binding protein TYPA
CLIM_RS04515	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CLIM_RS04520	COG1063	alcohol dehydrogenase
CLIM_RS04535	COG0492	ferredoxin-NADP+ reductase activity
CLIM_RS04540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CLIM_RS04545	COG0756	dUTP diphosphatase activity
CLIM_RS04550	COG2204	response regulator
CLIM_RS04580	COG0438	transferase activity, transferring glycosyl groups
CLIM_RS04610	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CLIM_RS04610	COG0493	'glutamate synthase
CLIM_RS04620	COG1522	sequence-specific DNA binding
CLIM_RS04665	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CLIM_RS04690	COG1337	RAMP superfamily
CLIM_RS04750	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLIM_RS04755	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLIM_RS04760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLIM_RS04765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLIM_RS04770	COG0519	Catalyzes the synthesis of GMP from XMP
CLIM_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
CLIM_RS04790	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
CLIM_RS04800	COG3876	Protein conserved in bacteria
CLIM_RS04805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLIM_RS04810	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLIM_RS04820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLIM_RS04825	COG0424	maF-like protein
CLIM_RS04830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLIM_RS04845	COG0101	tRNA pseudouridine synthase activity
CLIM_RS04850	COG3942	CHAP domain
CLIM_RS04850	COG1388	LysM domain
CLIM_RS04855	COG0003	Pfam Anion-transporting ATPase
CLIM_RS04860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLIM_RS04865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CLIM_RS04885	COG0347	Belongs to the P(II) protein family
CLIM_RS04890	COG0004	ammonium transporteR
CLIM_RS04900	COG0166	Belongs to the GPI family
CLIM_RS04905	COG1477	protein flavinylation
CLIM_RS04910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLIM_RS04910	COG2111	Na H antiporter
CLIM_RS04915	COG2111	Na H antiporter
CLIM_RS04920	COG1006	Multisubunit Na H antiporter MnhC subunit
CLIM_RS04925	COG0651	ATP synthesis coupled electron transport
CLIM_RS04930	COG1863	multisubunit Na H antiporter MnhE subunit
CLIM_RS04935	COG2212	antiporter activity
CLIM_RS04940	COG1320	monovalent cation:proton antiporter activity
CLIM_RS04945	COG4657	Part of a membrane complex involved in electron transport
CLIM_RS04950	COG4660	Part of a membrane complex involved in electron transport
CLIM_RS04960	COG4658	electron transport chain
CLIM_RS04965	COG4656	Part of a membrane complex involved in electron transport
CLIM_RS04970	COG2878	Part of a membrane complex involved in electron transport
CLIM_RS04980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLIM_RS04985	COG0617	tRNA 3'-terminal CCA addition
CLIM_RS04990	COG0673	inositol 2-dehydrogenase activity
CLIM_RS05000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLIM_RS05005	COG0494	nUDIX hydrolase
CLIM_RS05025	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLIM_RS05050	COG1120	ATPase activity
CLIM_RS05070	COG1648	precorrin-2 dehydrogenase activity
CLIM_RS05070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLIM_RS05105	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CLIM_RS05135	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CLIM_RS05180	COG0443	Heat shock 70 kDa protein
CLIM_RS05185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLIM_RS05190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CLIM_RS05205	COG3621	Patatin-like phospholipase
CLIM_RS05275	COG0602	queuosine metabolic process
CLIM_RS05285	COG0310	cobalt ion transport
CLIM_RS05300	COG1122	ATPase activity
CLIM_RS05305	COG4206	TonB-dependent receptor
CLIM_RS05310	COG0778	Nitroreductase
CLIM_RS05315	COG1492	cobalamin metabolic process
CLIM_RS05320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLIM_RS05325	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CLIM_RS05335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLIM_RS05340	COG1120	ATPase activity
CLIM_RS05375	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CLIM_RS05380	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CLIM_RS05385	COG2267	carboxylic ester hydrolase activity
CLIM_RS05390	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CLIM_RS05450	COG3118	belongs to the thioredoxin family
CLIM_RS05455	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CLIM_RS05475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLIM_RS05485	COG0237	dephospho-CoA kinase activity
CLIM_RS05495	COG0805	protein transport
CLIM_RS05500	COG0142	geranyltranstransferase activity
CLIM_RS05520	COG0038	chloride channel
CLIM_RS05535	COG1063	alcohol dehydrogenase
CLIM_RS05540	COG1950	PFAM Membrane protein of
CLIM_RS05545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLIM_RS05550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLIM_RS05555	COG1063	alcohol dehydrogenase
CLIM_RS05570	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLIM_RS05575	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CLIM_RS05580	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CLIM_RS05585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLIM_RS05610	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLIM_RS05615	COG2154	pterin-4-alpha-carbinolamine dehydratase
CLIM_RS05660	COG0644	oxidoreductase
CLIM_RS05705	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLIM_RS05715	COG1803	Methylglyoxal synthase
CLIM_RS05725	COG1342	Belongs to the UPF0251 family
CLIM_RS05735	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CLIM_RS05740	COG2897	thiosulfate sulfurtransferase activity
CLIM_RS05755	COG0428	transporter
CLIM_RS05765	COG1215	transferase activity, transferring glycosyl groups
CLIM_RS05770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CLIM_RS05790	COG1280	lysine exporter protein (LysE YggA)
CLIM_RS05805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLIM_RS05810	COG1032	radical SAM domain protein
CLIM_RS05820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLIM_RS05825	COG1702	phosphate starvation-inducible protein PhoH
CLIM_RS05830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLIM_RS05840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLIM_RS05850	COG0596	Alpha beta hydrolase
CLIM_RS05855	COG0193	aminoacyl-tRNA hydrolase activity
CLIM_RS05860	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CLIM_RS05865	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CLIM_RS05890	COG1230	cation diffusion facilitator family transporter
CLIM_RS05905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLIM_RS05925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLIM_RS05930	COG0436	Aminotransferase
CLIM_RS05940	COG1774	PSP1 C-terminal conserved region
CLIM_RS05945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLIM_RS05945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLIM_RS05970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLIM_RS06010	COG1970	mechanosensitive ion channel activity
CLIM_RS06015	COG0436	Aminotransferase
CLIM_RS06020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLIM_RS06020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLIM_RS06025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLIM_RS06030	COG0653	protein targeting
CLIM_RS06060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CLIM_RS06080	COG0003	Pfam Anion-transporting ATPase
CLIM_RS06090	COG0793	Belongs to the peptidase S41A family
CLIM_RS06145	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CLIM_RS06155	COG0750	zinc metalloprotease
CLIM_RS06160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CLIM_RS06165	COG0045	succinate-CoA ligase (ADP-forming) activity
CLIM_RS06170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLIM_RS06175	COG0390	transport system, permease component
CLIM_RS06180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLIM_RS06190	COG2119	membrane
CLIM_RS06205	COG1773	rubredoxin
CLIM_RS06215	COG4591	ABC-type transport system involved in lipoprotein release permease component
CLIM_RS06220	COG2199	diguanylate cyclase activity
CLIM_RS06230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLIM_RS06235	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLIM_RS06240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLIM_RS06245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLIM_RS06250	COG1438	arginine binding
CLIM_RS06255	COG0137	argininosuccinate synthase activity
CLIM_RS06260	COG0165	Argininosuccinate lyase
CLIM_RS06265	COG0793	Belongs to the peptidase S41A family
CLIM_RS06270	COG0191	fructose-bisphosphate aldolase activity
CLIM_RS06275	COG1473	amidohydrolase
CLIM_RS06280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLIM_RS06295	COG0698	ribose 5-phosphate isomerase
CLIM_RS06300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CLIM_RS06315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLIM_RS06345	COG1744	ABC transporter substrate-binding protein PnrA-like
CLIM_RS06360	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CLIM_RS06375	COG0791	NLP P60 protein
CLIM_RS06400	COG1136	(ABC) transporter
CLIM_RS06420	COG1309	transcriptional regulator
CLIM_RS06440	COG2204	response regulator
CLIM_RS06445	COG3852	Histidine kinase
CLIM_RS06465	COG5002	protein histidine kinase activity
CLIM_RS06515	COG3657	addiction module killer protein
CLIM_RS06520	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLIM_RS06565	COG4232	protein-disulfide reductase activity
CLIM_RS06580	COG0419	ATPase involved in DNA repair
CLIM_RS06585	COG0281	malic enzyme
CLIM_RS06600	COG0420	3'-5' exonuclease activity
CLIM_RS06630	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CLIM_RS06635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLIM_RS06675	COG2944	sequence-specific DNA binding
CLIM_RS06680	COG2026	Addiction module toxin, RelE StbE family
CLIM_RS06730	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLIM_RS06765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLIM_RS06775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLIM_RS06780	COG1074	ATP-dependent DNA helicase activity
CLIM_RS06785	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CLIM_RS06805	COG0415	Belongs to the DNA photolyase family
CLIM_RS06840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLIM_RS06840	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLIM_RS06845	COG1331	Highly conserved protein containing a thioredoxin domain
CLIM_RS06865	COG0439	Biotin carboxylase
CLIM_RS06875	COG0567	Dehydrogenase, E1 component
CLIM_RS06880	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLIM_RS06885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLIM_RS06920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLIM_RS06925	COG1454	alcohol dehydrogenase
CLIM_RS06950	COG1022	Amp-dependent synthetase and ligase
CLIM_RS06965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLIM_RS06970	COG0335	large ribosomal subunit rRNA binding
CLIM_RS06975	COG0336	Belongs to the RNA methyltransferase TrmD family
CLIM_RS06980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLIM_RS06985	COG0228	four-way junction DNA binding
CLIM_RS06990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLIM_RS06995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CLIM_RS06995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CLIM_RS07010	COG0793	Belongs to the peptidase S41A family
CLIM_RS07010	COG3409	Peptidoglycan-binding domain 1 protein
CLIM_RS07015	COG0251	oxidation-reduction process
CLIM_RS07020	COG0352	thiamine-phosphate diphosphorylase activity
CLIM_RS07025	COG0352	thiamine-phosphate diphosphorylase activity
CLIM_RS07030	COG0351	phosphomethylpyrimidine kinase
CLIM_RS07050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLIM_RS07055	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CLIM_RS07065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLIM_RS07075	COG0563	adenylate kinase activity
CLIM_RS07080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLIM_RS07100	COG1136	(ABC) transporter
CLIM_RS07110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CLIM_RS07125	COG1454	alcohol dehydrogenase
CLIM_RS07130	COG1342	Belongs to the UPF0251 family
CLIM_RS07145	COG2081	HI0933 family
CLIM_RS07170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLIM_RS07185	COG1902	pentaerythritol trinitrate reductase activity
CLIM_RS07215	COG2176	DNA-directed DNA polymerase activity
CLIM_RS07225	COG0501	Belongs to the peptidase M48B family
CLIM_RS07250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLIM_RS07260	COG1509	lysine 2,3-aminomutase activity
CLIM_RS07295	COG0497	DNA recombination
CLIM_RS07400	COG2003	Belongs to the UPF0758 family
CLIM_RS07440	COG0516	GMP reductase activity
CLIM_RS07460	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CLIM_RS07460	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CLIM_RS07465	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CLIM_RS07470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLIM_RS07475	COG0564	pseudouridine synthase activity
CLIM_RS07495	COG1770	oligopeptidase
CLIM_RS07505	COG0488	(ABC) transporter
CLIM_RS07540	COG1858	cytochrome C peroxidase
CLIM_RS07550	COG4221	oxidoreductase activity
CLIM_RS07560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLIM_RS07575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLIM_RS07580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLIM_RS07595	COG2050	protein possibly involved in aromatic compounds catabolism
CLIM_RS07600	COG1032	radical SAM domain protein
CLIM_RS07615	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLIM_RS07625	COG1295	ribonuclease BN
CLIM_RS07630	COG2270	Major facilitator Superfamily
CLIM_RS07635	COG0047	phosphoribosylformylglycinamidine synthase activity
CLIM_RS07640	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLIM_RS07650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLIM_RS07655	COG0095	Lipoate-protein ligase
CLIM_RS07665	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLIM_RS07685	COG1136	(ABC) transporter
CLIM_RS07705	COG2885	chlorophyll binding
CLIM_RS07705	COG3047	cAMP biosynthetic process
CLIM_RS07715	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLIM_RS07720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLIM_RS07725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLIM_RS07730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLIM_RS07735	COG0494	nUDIX hydrolase
CLIM_RS07755	COG2390	Transcriptional regulator
CLIM_RS07755	COG4584	PFAM Integrase catalytic
CLIM_RS07760	COG1484	DNA-dependent DNA replication
CLIM_RS07770	COG0658	competence protein
CLIM_RS07770	COG2333	competence protein COMEC
CLIM_RS07775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLIM_RS07785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLIM_RS07805	COG0436	Aminotransferase
CLIM_RS07830	COG0811	peptide transport
CLIM_RS07835	COG0848	biopolymer transport protein
CLIM_RS07870	COG4771	TonB-dependent receptor
CLIM_RS07880	COG4206	TonB-dependent receptor
CLIM_RS07910	COG4771	TonB-dependent receptor
CLIM_RS07925	COG4771	TonB-dependent receptor
CLIM_RS07935	COG0633	Ferredoxin
CLIM_RS07950	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLIM_RS07955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLIM_RS07960	COG1562	ergosterol biosynthetic process
CLIM_RS07965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLIM_RS07990	COG0343	queuine tRNA-ribosyltransferase activity
CLIM_RS07995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLIM_RS08010	COG1484	DNA-dependent DNA replication
CLIM_RS08015	COG4584	PFAM Integrase catalytic
CLIM_RS08015	COG2390	Transcriptional regulator
CLIM_RS08045	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLIM_RS08050	COG0531	amino acid
CLIM_RS08055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLIM_RS08060	COG0277	FAD linked oxidase domain protein
CLIM_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
CLIM_RS08120	COG0704	Plays a role in the regulation of phosphate uptake
CLIM_RS08125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLIM_RS08130	COG0581	inorganic phosphate transmembrane transporter activity
CLIM_RS08140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLIM_RS08170	COG0471	metal ion transport
CLIM_RS08170	COG0490	domain, Protein
CLIM_RS08195	COG0131	Imidazoleglycerol-phosphate dehydratase
CLIM_RS08200	COG1418	mRNA catabolic process
CLIM_RS08215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLIM_RS08215	COG0072	phenylalanine-tRNA ligase activity
CLIM_RS08245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLIM_RS08270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLIM_RS08275	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CLIM_RS08285	COG0135	phosphoribosylanthranilate isomerase activity
CLIM_RS08295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CLIM_RS08295	COG0475	glutathione-regulated potassium exporter activity
CLIM_RS08300	COG1592	Rubrerythrin
CLIM_RS08300	COG1773	rubredoxin
CLIM_RS08310	COG0659	secondary active sulfate transmembrane transporter activity
CLIM_RS08390	COG1538	Outer membrane efflux protein
CLIM_RS08405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLIM_RS08405	COG0731	radical SAM domain protein
CLIM_RS08415	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLIM_RS08420	COG0149	triose-phosphate isomerase activity
CLIM_RS08430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLIM_RS08455	COG0481	GTPase activity
CLIM_RS08460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLIM_RS08465	COG0242	peptide deformylase activity
CLIM_RS08475	COG0475	glutathione-regulated potassium exporter activity
CLIM_RS08475	COG0589	response to stress
CLIM_RS08480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CLIM_RS08485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLIM_RS08490	COG1136	(ABC) transporter
CLIM_RS08505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLIM_RS08510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLIM_RS08520	COG0484	heat shock protein binding
CLIM_RS08525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLIM_RS08530	COG1420	regulation of RNA biosynthetic process
CLIM_RS08535	COG2890	protein-(glutamine-N5) methyltransferase activity
CLIM_RS08545	COG0442	prolyl-tRNA aminoacylation
CLIM_RS08550	COG0450	alkyl hydroperoxide reductase
CLIM_RS08555	COG2252	PERMEase
CLIM_RS08565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLIM_RS08575	COG3604	Transcriptional regulator
CLIM_RS08580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CLIM_RS08595	COG1132	(ABC) transporter
CLIM_RS08600	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CLIM_RS08605	COG1032	radical SAM domain protein
CLIM_RS08610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLIM_RS08620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLIM_RS08625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLIM_RS08630	COG0039	L-malate dehydrogenase activity
CLIM_RS08640	COG2957	Belongs to the agmatine deiminase family
CLIM_RS08655	COG1575	Belongs to the MenA family. Type 1 subfamily
CLIM_RS08660	COG0492	ferredoxin-NADP+ reductase activity
CLIM_RS08675	COG0107	imidazoleglycerol-phosphate synthase activity
CLIM_RS08680	COG2321	neutral zinc metallopeptidase
CLIM_RS08695	COG0598	Magnesium transport protein CorA
CLIM_RS08715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLIM_RS08725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLIM_RS08730	COG1193	negative regulation of DNA recombination
CLIM_RS08735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CLIM_RS08740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLIM_RS08745	COG1968	undecaprenyl-diphosphatase activity
CLIM_RS08755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLIM_RS08760	COG1127	ABC transporter
CLIM_RS08770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLIM_RS08780	COG5002	protein histidine kinase activity
CLIM_RS08785	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CLIM_RS08795	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CLIM_RS08800	COG2205	protein histidine kinase activity
CLIM_RS08805	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CLIM_RS08815	COG0138	bifunctional purine biosynthesis protein purh
CLIM_RS08820	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CLIM_RS08830	COG0546	phosphoglycolate phosphatase activity
CLIM_RS08850	COG0750	zinc metalloprotease
CLIM_RS08890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLIM_RS08895	COG0602	queuosine metabolic process
CLIM_RS08900	COG0463	Glycosyl transferase, family 2
CLIM_RS08905	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CLIM_RS08910	COG2177	Part of the ABC transporter FtsEX involved in
CLIM_RS08925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLIM_RS08935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLIM_RS08950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLIM_RS08965	COG1091	dTDP-4-dehydrorhamnose reductase activity
CLIM_RS08990	COG0298	carbon dioxide binding
CLIM_RS08995	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CLIM_RS09005	COG0375	protein maturation
CLIM_RS09010	COG0540	Belongs to the ATCase OTCase family
CLIM_RS09025	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
CLIM_RS09040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLIM_RS09045	COG0322	excinuclease ABC activity
CLIM_RS09055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLIM_RS09060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLIM_RS09065	COG0084	hydrolase, TatD family'
CLIM_RS09075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLIM_RS09085	COG0436	Aminotransferase
CLIM_RS09095	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLIM_RS09100	COG3278	Belongs to the heme-copper respiratory oxidase family
CLIM_RS09130	COG2217	Heavy metal translocating P-type atpase
CLIM_RS09145	COG1271	oxidase subunit
CLIM_RS09150	COG1294	oxidase, subunit
CLIM_RS09155	COG2003	Belongs to the UPF0758 family
CLIM_RS09160	COG1278	Cold shock
CLIM_RS09165	COG4221	oxidoreductase activity
CLIM_RS09175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLIM_RS09180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLIM_RS09185	COG2873	o-acetylhomoserine
CLIM_RS09190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLIM_RS09190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLIM_RS09195	COG4974	Belongs to the 'phage' integrase family
CLIM_RS09215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CLIM_RS09225	COG2208	phosphoserine phosphatase activity
CLIM_RS09235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CLIM_RS09240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLIM_RS09255	COG1366	Belongs to the anti-sigma-factor antagonist family
CLIM_RS09270	COG1045	serine acetyltransferase
CLIM_RS09320	COG0438	transferase activity, transferring glycosyl groups
CLIM_RS09345	COG0861	Integral membrane protein TerC family
CLIM_RS09350	COG3158	transport of potassium into the cell
CLIM_RS09375	COG0167	dihydroorotate dehydrogenase activity
CLIM_RS09405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLIM_RS09420	COG0438	transferase activity, transferring glycosyl groups
CLIM_RS09445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLIM_RS09465	COG1083	cytidylyl-transferase
CLIM_RS09480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLIM_RS09490	COG0673	inositol 2-dehydrogenase activity
CLIM_RS09495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLIM_RS09530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLIM_RS09570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLIM_RS09575	COG3206	protein involved in exopolysaccharide biosynthesis
CLIM_RS09575	COG0489	protein tyrosine kinase activity
CLIM_RS09610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLIM_RS09665	COG1404	Belongs to the peptidase S8 family
CLIM_RS09680	COG3588	fructose-bisphosphate aldolase
CLIM_RS09685	COG1979	alcohol dehydrogenase
CLIM_RS09720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLIM_RS09730	COG0493	'glutamate synthase
CLIM_RS09735	COG0070	glutamate synthase
CLIM_RS09735	COG0069	glutamate synthase activity
CLIM_RS09735	COG0067	glutamate synthase
CLIM_RS09740	COG0588	phosphoglycerate mutase activity
CLIM_RS09760	COG0590	tRNA wobble adenosine to inosine editing
CLIM_RS09765	COG0045	succinate-CoA ligase (ADP-forming) activity
CLIM_RS09775	COG1136	(ABC) transporter
CLIM_RS09775	COG0577	efflux transmembrane transporter activity
CLIM_RS09780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLIM_RS09795	COG0488	(ABC) transporter
CLIM_RS09800	COG2205	protein histidine kinase activity
CLIM_RS09800	COG5002	protein histidine kinase activity
CLIM_RS09800	COG0784	Response regulator, receiver
CLIM_RS09815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLIM_RS09820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLIM_RS09830	COG1252	NADH dehydrogenase
CLIM_RS09840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLIM_RS09860	COG0848	biopolymer transport protein
CLIM_RS09870	COG0811	peptide transport
CLIM_RS09875	COG0358	DNA primase activity
CLIM_RS09880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLIM_RS09885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLIM_RS09885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLIM_RS09890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLIM_RS09905	COG1850	ribulose-bisphosphate carboxylase activity
CLIM_RS09910	COG1830	Aldolase
CLIM_RS09915	COG1028	Short-chain dehydrogenase reductase Sdr
CLIM_RS09915	COG3347	Dehydrogenase
CLIM_RS09935	COG1032	radical SAM domain protein
CLIM_RS09955	COG1151	hydroxylamine reductase activity
CLIM_RS09975	COG2226	methyltransferase
CLIM_RS09990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLIM_RS09995	COG1196	nuclear chromosome segregation
CLIM_RS10005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLIM_RS10010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLIM_RS10015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLIM_RS10030	COG0248	Ppx GppA phosphatase
CLIM_RS10040	COG0009	L-threonylcarbamoyladenylate synthase
CLIM_RS10050	COG1187	pseudouridine synthase activity
CLIM_RS10055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLIM_RS10060	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLIM_RS10065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLIM_RS10070	COG0543	2 iron, 2 sulfur cluster binding
CLIM_RS10075	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLIM_RS10075	COG0493	'glutamate synthase
CLIM_RS10080	COG0864	Transcriptional regulator
CLIM_RS10090	COG0310	cobalt ion transport
CLIM_RS10100	COG1122	ATPase activity
CLIM_RS10120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLIM_RS10125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLIM_RS10130	COG2226	methyltransferase
CLIM_RS10145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLIM_RS10155	COG1136	(ABC) transporter
CLIM_RS10170	COG0798	PFAM Bile acid sodium symporter
CLIM_RS10175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLIM_RS10235	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CLIM_RS10245	COG1570	exodeoxyribonuclease VII activity
CLIM_RS10250	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CLIM_RS10255	COG1490	D-aminoacyl-tRNA deacylase activity
CLIM_RS10260	COG1872	DUF167
CLIM_RS10265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLIM_RS10270	COG0372	Belongs to the citrate synthase family
CLIM_RS10300	COG1169	isochorismate synthase
CLIM_RS10305	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CLIM_RS10310	COG0596	Alpha beta hydrolase
CLIM_RS10315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CLIM_RS10320	COG4948	Mandelate Racemase Muconate Lactonizing
CLIM_RS10325	COG0318	PFAM AMP-dependent synthetase and ligase
CLIM_RS10335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLIM_RS10340	COG1475	DNA binding
CLIM_RS10345	COG1192	Involved in chromosome partitioning
CLIM_RS10350	COG2094	Belongs to the DNA glycosylase MPG family
CLIM_RS10355	COG2239	Acts as a magnesium transporter
CLIM_RS10365	COG0482	sulfurtransferase activity
CLIM_RS10370	COG0400	carboxylic ester hydrolase activity
CLIM_RS10375	COG1410	methionine synthase
CLIM_RS10375	COG0646	methionine synthase
CLIM_RS10380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLIM_RS10445	COG0363	glucosamine-6-phosphate deaminase activity
CLIM_RS10450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CLIM_RS10455	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CLIM_RS10475	COG0438	transferase activity, transferring glycosyl groups
CLIM_RS10490	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLIM_RS10495	COG1012	belongs to the aldehyde dehydrogenase family
CLIM_RS10500	COG1132	(ABC) transporter
CLIM_RS10505	COG0861	Integral membrane protein TerC family
CLIM_RS10510	COG1067	ATP-dependent peptidase activity
CLIM_RS10520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLIM_RS10530	COG0826	peptidase U32
CLIM_RS10550	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CLIM_RS10620	COG1047	Peptidyl-prolyl cis-trans
CLIM_RS10630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLIM_RS10650	COG1032	radical SAM domain protein
CLIM_RS10655	COG0724	RNA recognition motif
CLIM_RS10660	COG1078	dGTPase activity
CLIM_RS10670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLIM_RS10675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLIM_RS10680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLIM_RS10695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLIM_RS10710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLIM_RS10715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLIM_RS10720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLIM_RS10725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLIM_RS10730	COG0612	Peptidase, M16
CLIM_RS10735	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLIM_RS10740	COG0736	holo-[acyl-carrier-protein] synthase activity
CLIM_RS10745	COG0157	Belongs to the NadC ModD family
CLIM_RS10785	COG0003	Pfam Anion-transporting ATPase
CLIM_RS10790	COG0543	2 iron, 2 sulfur cluster binding
CLIM_RS10795	COG0629	single-stranded DNA binding
CLIM_RS10810	COG0156	8-amino-7-oxononanoate synthase activity
CLIM_RS10820	COG1429	ligase activity, forming nitrogen-metal bonds
CLIM_RS10830	COG1429	ligase activity, forming nitrogen-metal bonds
CLIM_RS10845	COG0071	Belongs to the small heat shock protein (HSP20) family
CLIM_RS10900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLIM_RS10910	COG0170	dolichyl monophosphate biosynthetic process
CLIM_RS10915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CLIM_RS10920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLIM_RS10930	COG1104	cysteine desulfurase activity
CLIM_RS10940	COG0300	oxidoreductase activity
CLIM_RS10955	COG0105	UTP biosynthetic process
CLIM_RS10975	COG1940	carbohydrate kinase activity
CLIM_RS10980	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLIM_RS10990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLIM_RS10995	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CLIM_RS11000	COG0297	glycogen (starch) synthase activity
CLIM_RS11015	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CLIM_RS11020	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CLIM_RS11025	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CLIM_RS11035	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLIM_RS11040	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLIM_RS11045	COG0215	cysteine-tRNA ligase activity
CLIM_RS11055	COG0357	Ribosomal RNA small subunit methyltransferase G
CLIM_RS11060	COG0203	ribosomal protein L17
CLIM_RS11065	COG0202	RNA polymerase activity
CLIM_RS11070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLIM_RS11075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLIM_RS11080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLIM_RS11085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLIM_RS11100	COG0200	Binds to the 23S rRNA
CLIM_RS11105	COG1841	ribosomal large subunit assembly
CLIM_RS11110	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLIM_RS11115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLIM_RS11120	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLIM_RS11125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLIM_RS11130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLIM_RS11135	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLIM_RS11140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLIM_RS11150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLIM_RS11155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLIM_RS11160	COG0255	Belongs to the universal ribosomal protein uL29 family
CLIM_RS11165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLIM_RS11170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLIM_RS11175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLIM_RS11180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLIM_RS11185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLIM_RS11190	COG0089	rRNA binding
CLIM_RS11195	COG0088	Forms part of the polypeptide exit tunnel
CLIM_RS11200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLIM_RS11205	COG0051	transcription antitermination factor activity, RNA binding
CLIM_RS11210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLIM_RS11215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLIM_RS11220	COG0049	tRNA binding
CLIM_RS11225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLIM_RS11245	COG1077	Cell shape determining protein MreB Mrl
CLIM_RS11250	COG2824	Alkylphosphonate utilization operon protein PhnA
CLIM_RS11295	COG2050	protein possibly involved in aromatic compounds catabolism
CLIM_RS11430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLIM_RS11445	COG0438	transferase activity, transferring glycosyl groups
CLIM_RS11460	COG0297	glycogen (starch) synthase activity
CLIM_RS11465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLIM_RS11470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CLIM_RS11475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLIM_RS11485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLIM_RS11495	COG0542	response to heat
CLIM_RS11525	COG0714	Associated with various cellular activities
CLIM_RS11535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLIM_RS11540	COG1862	Preprotein translocase
CLIM_RS11545	COG0505	Belongs to the CarA family
CLIM_RS11550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CLIM_RS11560	COG1032	radical SAM domain protein
CLIM_RS11565	COG3245	cytochrome
CLIM_RS11570	COG3245	cytochrome
CLIM_RS11575	COG4095	Psort location CytoplasmicMembrane, score
CLIM_RS11580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLIM_RS11595	COG0315	cyclic pyranopterin monophosphate synthase activity
CLIM_RS11595	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLIM_RS11600	COG0584	glycerophosphoryl diester phosphodiesterase
CLIM_RS11610	COG0315	cyclic pyranopterin monophosphate synthase activity
CLIM_RS11610	COG0746	molybdenum cofactor guanylyltransferase activity
CLIM_RS11620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLIM_RS11625	COG1121	(ABC) transporter
CLIM_RS11630	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLIM_RS11640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLIM_RS11650	COG0842	Transport permease protein
CLIM_RS11655	COG1131	(ABC) transporter
CLIM_RS11675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLIM_RS11690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLIM_RS11695	COG1058	Belongs to the CinA family
CLIM_RS11695	COG1546	Belongs to the CinA family
CLIM_RS11700	COG0460	homoserine dehydrogenase
CLIM_RS11700	COG0527	aspartate kinase activity
CLIM_RS11705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLIM_RS11710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLIM_RS11715	COG0083	homoserine kinase activity
CLIM_RS11730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLIM_RS11735	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CLIM_RS11745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLIM_RS11755	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLIM_RS11760	COG2048	Heterodisulfide reductase, subunit B
CLIM_RS11765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CLIM_RS11775	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CLIM_RS11775	COG0517	IMP dehydrogenase activity
CLIM_RS11780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLIM_RS11830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CLIM_RS11835	COG3876	Protein conserved in bacteria
CLIM_RS11850	COG0702	epimerase
CLIM_RS11870	COG0003	Pfam Anion-transporting ATPase
CLIM_RS11880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CLIM_RS11885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CLIM_RS11905	COG2353	YceI-like domain
CLIM_RS11915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLIM_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
CLIM_RS11925	COG3956	TIGRFAM MazG family protein
CLIM_RS11940	COG0366	Alpha amylase catalytic
CLIM_RS11945	COG0366	Alpha amylase catalytic
CLIM_RS11950	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CLIM_RS11960	COG4942	peptidase
CLIM_RS12005	COG1381	Involved in DNA repair and RecF pathway recombination
CLIM_RS12010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLIM_RS12030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLIM_RS12040	COG0243	molybdopterin cofactor binding
CLIM_RS12045	COG0437	4 iron, 4 sulfur cluster binding
CLIM_RS12050	COG3301	Polysulphide reductase, NrfD
CLIM_RS12060	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLIM_RS12065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLIM_RS12070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLIM_RS12075	COG0287	Prephenate dehydrogenase
CLIM_RS12080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLIM_RS12095	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CLIM_RS12100	COG0542	response to heat
CLIM_RS12105	COG1472	Belongs to the glycosyl hydrolase 3 family
CLIM_RS12115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLIM_RS12120	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLIM_RS12125	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLIM_RS12130	COG0527	aspartate kinase activity
CLIM_RS12135	COG0791	NLP P60 protein
CLIM_RS12140	COG2264	protein methyltransferase activity
CLIM_RS12145	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLIM_RS12145	COG0248	Ppx GppA phosphatase
CLIM_RS12155	COG0318	PFAM AMP-dependent synthetase and ligase
CLIM_RS12165	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CLIM_RS12170	COG4106	trans-aconitate 2-methyltransferase activity
CLIM_RS12180	COG0156	8-amino-7-oxononanoate synthase activity
CLIM_RS12185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLIM_RS12195	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLIM_RS12200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLIM_RS12205	COG1918	ferrous iron import across plasma membrane
CLIM_RS12205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLIM_RS12210	COG1918	ferrous iron import across plasma membrane
CLIM_RS12215	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CLIM_RS12220	COG0537	adenosine 5'-monophosphoramidase activity
CLIM_RS12230	COG1253	flavin adenine dinucleotide binding
CLIM_RS12245	COG1053	succinate dehydrogenase
CLIM_RS12255	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CLIM_RS12270	COG1785	Belongs to the alkaline phosphatase family
CLIM_RS12340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CLIM_RS12375	COG3645	SOS response
CLIM_RS12380	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CLIM_RS12425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLIM_RS12430	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CLIM_RS12435	COG0180	Tryptophanyl-tRNA synthetase
CLIM_RS12440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLIM_RS12445	COG0018	arginyl-trna synthetase
CLIM_RS12450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLIM_RS12475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLIM_RS12480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLIM_RS12485	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLIM_RS12505	COG1496	oxidoreductase activity
CLIM_RS12515	COG2813	Specifically methylates the guanine in position
CLIM_RS12520	COG0427	acetyl-CoA hydrolase
CLIM_RS12540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLIM_RS12545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLIM_RS12550	COG0772	Belongs to the SEDS family
CLIM_RS12555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLIM_RS12560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLIM_RS12565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLIM_RS12570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLIM_RS12575	COG0768	penicillin binding
CLIM_RS12585	COG0275	rRNA processing
CLIM_RS12590	COG2001	Belongs to the MraZ family
CLIM_RS12605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLIM_RS12610	COG0126	phosphoglycerate kinase activity
CLIM_RS12625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLIM_RS12630	COG1940	carbohydrate kinase activity
CLIM_RS12635	COG0671	phosphoesterase, PA-phosphatase related
CLIM_RS12640	COG0706	membrane insertase activity
CLIM_RS12645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLIM_RS12650	COG0594	ribonuclease P activity
CLIM_RS12685	COG0438	transferase activity, transferring glycosyl groups
CLIM_RS12710	COG0784	Response regulator, receiver
CLIM_RS12710	COG5002	protein histidine kinase activity
CLIM_RS12710	COG2205	protein histidine kinase activity
CLIM_RS12720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLIM_RS12770	COG2801	Transposase and inactivated derivatives